Zfp575

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Zfp575	0.5	0.14	2.6e-09	0.04	0.08	0.08	0.07	7.0e-05	2.2e-09	3.9e-09	8.3e-08
2	OFC	gene expression	Zfp575	0.38	0.23	7.1e-05	0.08	0.16	0.1	0.1	6.8e-03	1.5e-04	2.2e-03	2.1e-03
3	Brain	gene expression	Zfp575	0.08	0.05	2.8e-06	0.06	0.06	0.04	0.06	3.6e-06	6.7e-06	5.1e-05	3.1e-06
4	PL	gene expression	Zfp575	0.04	0.03	2.6e-05	0.04	0.04	0.04	0.04	7.1e-05	3.2e-05	8.9e-05	2.2e-05
5	NAcc	gene expression	Zfp575	0.04	0.03	7.0e-05	0.02	0.03	0.02	0.02	1.1e-03	3.1e-04	9.9e-04	8.4e-04
6	Brain	mRNA stability	Zfp575	0.12	0.12	3.2e-04	0.04	0.03	0.05	0.04	1.8e-04	4.6e-04	1.6e-05	1.6e-04
7	LHb	gene expression	Zfp575	0.57	0.28	6.9e-03	0.03	0.07	0.01	0.05	6.4e-02	1.2e-02	1.9e-01	2.7e-02
8	BLA	isoform ratio	XM_006228430.4	0.2	0.14	6.0e-03	-0	0	0.01	0	5.5e-01	1.7e-01	1.2e-01	2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.3	0.5	-0.1	-0.3	-0.4	-0.3	0.6	0.5	-0.2
Area under the delay curve	0.3	0.3	1.3	0.0	1.1	0.5	0.5	0.5	-0.3	0.5	-0.1
BMI with tail	0.6	1.8	3.0	0.0	-1.7	-1.6	-1.6	-1.6	1.4	1.4	-0.5
BMI without tail	0.7	1.5	5.3	2.3	-1.3	-1.2	-1.1	-1.3	0.8	0.6	-0.3
Body weight	0.8	3.3	5.0	-0.3	-2.2	-2.1	-2.1	-2.2	2.0	1.3	-1.4
Weight adjusted by age	2.2	2.5	17.8	4.2	0.3	0.1	0.1	-0.2	-0.2	-1.3	-0.7
Bone surface	0.4	0.7	1.7	-0.8	-0.7	-0.9	-0.9	-0.7	0.7	1.3	-0.4
Bone volume	0.3	0.6	1.2	-0.2	-0.4	-0.7	-0.8	-0.7	1.1	1.0	-0.7
Breakpoint value in progressive ratio session	1.8	1.9	5.0	0.8	2.2	1.8	1.8	1.7	-0.8	-0.1	0.3
Number of licking bursts	1.2	1.4	2.8	0.1	-1.2	-1.3	-1.3	-1.3	1.7	0.5	-1.3
Context. condit. distance diff. score	0.2	0.2	0.3	0.2	-0.6	-0.5	-0.5	-0.6	0.3	0.5	-0.4
Locomotion velocity, session 1	0.1	0.1	0.6	-0.3	-0.0	-0.4	-0.3	-0.2	-0.0	0.8	-0.2
Locomotion distance, session 1	0.3	0.3	0.6	-0.3	-0.4	-0.6	-0.6	-0.6	0.7	0.8	-0.5
Locomotion velocity, session 2	0.1	0.1	0.2	0.2	-0.5	-0.3	-0.2	-0.2	-0.4	-0.5	0.5
Locomotion distance, session 2	0.1	0.2	0.7	-0.7	-0.4	-0.3	-0.2	-0.0	0.1	0.1	0.8
Locomotion velocity, session 3	0.1	0.2	0.7	-0.6	-0.3	0.1	0.1	0.2	-0.3	-0.0	0.9
Locomotion distance, session 3	3.0	3.3	4.4	1.5	1.4	1.9	1.9	2.1	-1.8	-1.7	2.1
Stereotopy head waving bouts, day 3	0.2	0.2	1.1	0.1	-0.7	0.1	0.1	-0.1	-0.4	-1.0	0.3
Stereotopy head waving duration, day 3	0.5	0.6	1.3	-1.0	-1.1	-0.9	-0.8	-0.9	0.6	0.3	-0.4
Locomotion velocity, session 7	0.2	0.3	0.9	-0.7	0.2	0.3	0.2	0.5	-0.5	0.3	0.9
Locomotion distance, session 7	0.2	0.2	0.6	-0.5	-0.5	-0.5	-0.6	-0.3	0.3	0.8	0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	-0.8	-0.8	-0.3	-0.2	-0.2	-0.1	0.2	0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.8	-0.8	-0.9	-0.7	-0.6	-0.6	0.3	0.5	-0.1
Locomotion velocity, session 8	0.8	1.0	2.6	0.0	0.5	1.0	1.0	1.1	-1.3	-0.5	1.6
Locomotion distance, session 8	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.2	-0.3	0.3	0.2	-0.1
Degree of sensitization distance	3.7	3.7	4.5	-1.5	-1.5	-2.1	-2.1	-2.1	2.0	2.1	-1.7
Degree of sensitization stereotypy	0.2	0.3	0.9	-0.5	-0.9	-0.5	-0.5	-0.4	0.2	0.4	0.1
Conditioned locomotion	2.8	3.3	4.6	1.0	1.0	1.9	1.9	1.9	-2.2	-2.1	2.2
Cocaine response after cond. corrected	0.1	0.2	0.5	-0.2	-0.7	-0.3	-0.3	-0.3	0.2	-0.6	-0.0
Cocaine response after cond. not corrected	0.3	0.4	1.4	-0.1	-1.2	-0.5	-0.4	-0.4	0.2	-0.8	0.4
Cocaine response before conditioning	0.3	0.4	1.2	0.1	-1.0	-0.3	-0.2	-0.1	-0.4	-0.6	1.1
Saline control response	0.6	0.8	1.5	-0.1	-1.2	-1.1	-1.1	-1.0	0.9	0.7	-0.3
Bone: connectivity density	0.2	0.3	1.3	-0.6	-0.2	-0.3	-0.4	-0.1	0.1	1.2	0.2
Bone: cortical apparent density	0.1	0.2	0.7	0.4	0.2	-0.1	-0.1	-0.3	0.3	-0.4	-0.8
Bone: cortical area	0.6	1.0	2.2	1.5	-0.9	-0.9	-0.9	-1.1	1.2	0.2	-0.6
Bone: cortical porosity	4.0	4.4	7.1	0.6	1.3	2.2	2.2	2.2	-2.7	-2.4	2.3
Bone: cortical porosity	3.1	3.4	5.5	0.5	1.0	1.9	1.9	1.8	-2.3	-2.3	2.2
Bone: cortical thickness	0.3	0.5	3.1	1.8	-0.2	-0.3	-0.2	-0.5	0.8	-0.4	-0.3
Bone: cortical thickness	0.3	0.3	0.8	0.4	-0.9	-0.6	-0.6	-0.7	0.6	-0.3	0.1
Bone: cortical tissue density	0.1	0.1	0.6	0.4	0.2	-0.0	0.0	-0.2	0.2	-0.4	-0.8
Condit. Reinf. active minus inactive responses	0.4	0.4	0.8	-0.6	-0.8	-0.6	-0.8	-0.6	0.9	0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.2	-0.6	-1.0	-1.0	-1.1	-0.9	1.0	0.8	-0.4
Condit. Reinf. active responses	0.2	0.2	0.6	-0.8	-0.7	-0.4	-0.5	-0.3	0.0	0.2	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.7	-0.4	-0.0	0.2	0.1	0.1	-0.9	-0.1	0.2
Incentive salience index mean	0.1	0.1	0.6	-0.4	-0.3	0.0	-0.1	0.1	-0.2	-0.1	0.8
Condit. Reinf. lever presses	0.3	0.4	1.5	-0.4	0.2	0.5	0.4	0.7	-0.9	0.1	1.2
Condit. Reinf. active minus inactive responses	0.2	0.2	1.0	-0.6	-0.4	-0.1	-0.0	0.2	-0.0	0.3	1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.3	-0.7	0.0	0.1	0.1	-0.3	-0.8	0.6
Condit. Reinf. active responses	0.3	0.5	2.1	0.0	0.3	0.5	0.6	0.8	-0.5	0.0	1.5
Condit. Reinf. inactive responses	0.5	0.6	1.6	0.2	0.9	0.7	0.7	0.9	-0.6	0.4	1.3
Condit. Reinf. lever presses	1.2	1.6	2.6	0.1	-1.3	-1.5	-1.5	-1.5	1.6	1.3	-0.5
Condit. Reinf. lever reinforcers received	0.5	0.7	2.8	0.0	0.4	0.7	0.7	1.0	-0.6	-0.1	1.7
Conditioned reinforcement - actives	1.2	1.2	5.6	-2.4	-1.3	-0.9	-0.9	-0.8	0.1	0.6	0.0
Conditioned reinforcement - inactives	0.8	0.9	5.4	-2.3	-0.8	-0.4	-0.4	-0.2	0.0	0.3	0.8
Conditioned locomotion	2.3	2.7	6.4	-2.5	-2.2	-1.7	-1.7	-1.7	0.7	1.0	-0.8
Patch foraging indifference point 0 sec	0.4	0.6	2.9	1.7	-0.5	-0.2	-0.2	-0.2	-0.0	0.4	1.1
Patch foraging indifference point AUC	1.3	1.4	3.0	-1.2	-1.7	-1.3	-1.3	-1.1	1.3	0.8	0.1
Delay disc. indifference point, 0s delay	1.7	1.9	2.4	1.6	1.3	1.5	1.5	1.5	-1.2	-0.6	1.5
Delay disc. indifference point, 16s delay	0.4	0.4	1.3	-1.1	0.7	-0.1	-0.1	-0.1	0.3	0.7	-1.0
Delay disc. indifference point, 2s delay	0.5	0.6	2.1	0.4	1.5	0.4	0.4	0.4	0.3	1.1	-0.8
Delay disc. indifference point, 24s delay	2.0	2.0	3.2	-1.5	-1.1	-1.7	-1.7	-1.4	1.1	1.8	-0.6
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.1	-0.2	0.1	0.1	0.1	0.1	0.0	0.3
Delay disc. indifference point, 8s delay	0.3	0.3	1.4	-0.0	1.2	0.5	0.5	0.5	-0.4	0.3	-0.1
Indifference point function ln k	0.3	0.5	1.0	1.0	1.0	0.6	0.6	0.4	-0.4	-0.6	-0.6
Indifference point function log k	0.3	0.5	1.0	1.0	1.0	0.6	0.6	0.4	-0.4	-0.6	-0.6
Patch foraging total patch changes 0 sec	0.4	0.7	1.7	1.3	-0.9	-0.7	-0.7	-0.6	0.4	1.0	0.7
Patch foraging total patch changes 12 sec	0.3	0.4	1.8	-0.4	-0.9	-0.3	-0.2	-0.1	0.7	0.3	1.3
Patch foraging total patch changes 18 sec	2.4	3.1	4.8	-1.0	-2.2	-2.0	-2.0	-1.8	1.7	2.1	-0.3
Patch foraging total patch changes 24 sec	1.2	1.5	5.5	-2.4	-1.0	-0.8	-0.8	-0.4	0.9	1.6	0.7
Patch foraging total patch changes 6 sec	0.4	0.7	2.1	-0.3	-1.4	-0.7	-0.7	-0.5	0.1	0.6	1.2
Patch foraging time to switch 0 sec	1.6	2.5	5.2	-1.9	2.3	1.9	1.9	1.7	-1.1	-0.4	-0.1
Patch foraging water rate 0 sec	1.6	2.6	6.7	-0.3	-2.6	-2.1	-2.1	-1.8	1.0	1.0	0.1
Patch foraging water rate 12 sec	0.4	0.7	1.2	-0.3	-1.0	-1.1	-1.1	-0.9	0.1	1.0	-0.2
Patch foraging water rate 18 sec	0.7	1.0	1.5	0.1	-0.9	-1.2	-1.2	-1.2	0.7	1.2	-0.8
Patch foraging water rate 24 sec	0.7	0.9	1.5	-0.1	-1.2	-1.2	-1.2	-1.1	0.8	0.8	-0.6
Patch foraging water rate 6 sec	3.0	4.3	7.3	-2.7	-1.7	-2.2	-2.2	-2.0	1.6	2.5	-1.5
Seeking ratio, delayed vs. immediate footshock	3.4	3.9	12.5	3.5	1.7	2.0	1.9	1.8	-0.7	-1.4	1.7
Distance traveled before self-admin	2.3	2.5	17.6	4.2	-0.2	-0.0	-0.0	-0.5	-0.3	-1.2	-0.4
Distance traveled after self-admin	2.2	2.4	10.2	3.2	1.2	1.3	1.3	0.9	-1.1	-1.6	0.3
Extensor digitorum longus weight	1.8	7.3	11.1	0.3	-2.6	-3.1	-2.9	-3.3	3.3	1.7	-2.9
Bone: elastic displacement	1.3	1.5	1.9	1.0	1.3	1.3	1.4	1.3	-1.4	-0.8	1.2
Bone: elastic work	0.6	0.8	3.5	1.9	0.1	0.5	0.5	0.4	-0.7	-0.9	1.0
Bone: endosteal estimation	0.0	0.0	0.2	-0.3	0.0	0.0	0.0	0.1	0.1	0.4	0.3
Bone: endosteal perimeter	0.1	0.2	0.4	0.3	-0.1	-0.3	-0.3	-0.4	0.6	0.7	-0.5
Epididymis fat weight	0.2	0.5	1.7	-0.8	1.3	0.7	0.7	0.8	-0.1	0.3	-0.1
Delta time in closed arm before/after self-admin	0.5	0.4	1.8	1.4	-0.3	-0.4	-0.4	-0.6	0.6	0.0	-0.8
Delta time in open arm before/after self-admin	1.0	1.0	3.4	-1.8	0.7	0.8	0.8	1.1	-0.4	-0.4	1.1
Diff in mean of infusions in LGA sessions	1.1	1.2	2.9	-0.3	1.7	1.3	1.3	1.4	-0.9	0.4	0.5
Delay discount exponential model param	0.2	0.2	0.8	0.1	-0.9	-0.2	-0.2	-0.3	0.1	-0.7	0.2
Extinction: sum of active levers before priming	5.4	5.4	17.1	4.1	1.8	2.4	2.3	1.9	-1.5	-1.7	1.7
Active lever presses in extinction session 6	1.6	1.6	8.6	-2.9	-0.4	-0.6	-0.6	-0.5	0.9	1.3	-0.8
Bone: final force	0.2	0.3	1.1	1.1	-0.5	-0.4	-0.3	-0.6	0.7	-0.3	-0.4
Bone: final moment	0.3	0.4	1.5	1.2	-0.6	-0.4	-0.3	-0.7	0.7	-0.4	-0.4
Food consumed during 24 hour testing period	1.9	2.3	3.9	-0.7	1.9	1.8	1.8	2.0	-1.1	0.4	1.7
Glucose	0.3	0.5	1.6	0.4	0.3	0.6	0.4	0.8	-1.0	-0.2	1.3
Heart weight	1.3	1.8	4.6	0.2	-2.2	-1.6	-1.6	-1.8	1.0	0.1	-0.7
Delay discount hyperbolic model param	0.2	0.2	0.7	0.1	-0.7	-0.1	-0.1	-0.2	-0.1	-0.9	0.2
Intermittent access intake day 1-15 change	0.8	0.8	1.6	-0.4	-0.9	-1.1	-1.1	-1.2	0.6	0.5	-1.3
Intermittent access intake escalation	0.8	0.8	1.6	-0.8	-0.8	-1.0	-1.0	-1.1	0.5	0.5	-1.3
Intermittent access intake escalation 2	0.4	0.4	1.5	1.2	-0.5	-0.3	-0.4	-0.5	-0.4	-0.6	-0.4
Intermitt. access day 1 inactive lever presses	0.8	0.9	1.6	0.3	-0.8	-1.3	-1.3	-1.1	0.9	0.5	-0.7
Intermitt. access day 15 inactive lever presses	2.7	3.0	4.3	-1.1	-1.3	-1.9	-1.9	-2.0	1.7	1.6	-2.1
Intermitt. access escalation Index	0.2	0.1	0.4	-0.1	0.4	0.2	0.2	0.3	0.6	0.6	0.2
Intermittent access day 1 total infusions	0.7	0.8	3.1	-1.8	-1.2	-0.7	-0.7	-0.6	0.3	0.7	0.4
Intermittent access day 15 total infusions	2.9	3.2	16.2	-4.0	-1.3	-1.2	-1.2	-1.1	0.9	1.6	-0.7
Intermittent access terminal intake (last 3 days)	2.5	2.8	11.5	-3.4	-1.5	-1.3	-1.3	-1.1	1.0	1.6	-0.3
Intermittent access total infusions	3.1	3.4	14.6	-3.8	-1.8	-1.5	-1.5	-1.3	1.1	1.4	-0.3
Intermittent access day 1 locomotion	0.9	1.0	5.7	-2.4	-0.4	0.2	0.2	0.4	-0.2	0.3	1.3
Intermittent access day 15 total locomotion	0.9	1.0	3.7	-1.9	-1.1	-0.8	-0.8	-0.8	0.5	0.7	-0.2
Intermittent access total locomotion	2.4	2.8	12.8	-3.6	-1.8	-1.3	-1.3	-1.1	0.9	1.0	-0.2
Intermittent access standard deviation	1.9	2.0	9.8	-3.1	-1.2	-1.1	-1.1	-1.1	0.1	0.7	-1.1
Left kidney weight	3.4	9.6	20.0	-2.7	-4.5	-3.5	-3.5	-3.6	2.8	1.4	-1.5
Right kidney weight	3.0	8.3	16.2	-2.4	-4.0	-3.3	-3.2	-3.4	2.8	1.3	-1.5
Cocaine induced anxiety	0.3	0.3	0.9	-0.6	1.0	0.3	0.3	0.6	0.6	0.5	-0.0
Post-drug Anxiety	0.4	0.4	1.4	-1.0	0.1	-0.4	-0.4	-0.2	1.2	0.6	-0.7
Baseline Anxiety	0.6	0.6	1.0	-0.5	-1.0	-0.9	-0.9	-1.0	0.6	0.3	-0.8
Tail length	0.4	1.2	7.3	2.7	-0.4	-0.6	-0.6	-0.8	0.6	0.1	-0.6
Length with tail	0.5	1.7	3.0	-0.2	-1.2	-1.4	-1.4	-1.6	1.5	0.6	-1.7
Length without tail	1.3	2.9	9.4	-3.1	-1.2	-1.5	-1.5	-1.3	1.6	1.5	-1.3
Times rat made contact with spout	0.2	0.2	1.0	1.0	0.0	0.2	0.2	-0.1	0.1	-0.8	-0.2
Lifetime Intake	2.1	2.3	11.0	-3.3	-1.5	-1.1	-1.1	-1.0	0.8	1.1	-0.0
Liver weight, left	6.7	10.7	16.1	-2.0	-4.0	-3.9	-3.8	-3.9	3.1	2.4	-2.4
Liver weight, right	2.7	4.5	6.0	-1.8	-2.3	-2.4	-2.4	-2.4	1.9	2.0	-1.5
Locomotor activity	0.2	0.3	1.0	0.0	-1.0	-0.6	-0.5	-0.7	0.6	-0.3	-0.4
Locomotor testing distance	0.2	0.3	0.8	-0.9	-0.6	-0.4	-0.3	-0.4	0.9	0.2	-0.5
Locomotor testing rearing	2.0	3.1	6.8	-0.2	-2.6	-2.1	-2.2	-2.2	1.6	0.9	-0.9
Locomotion in novel chamber	1.5	1.8	8.0	2.8	1.2	1.2	1.2	0.9	-0.4	-1.1	0.4
Locomotion in novel chamber post-restriction	1.6	1.9	3.1	1.5	1.5	1.6	1.6	1.2	-1.0	-1.8	-0.4
Fecal boli incidents, locomotor time 1	0.7	0.8	3.6	1.9	0.1	-0.0	-0.1	-0.4	-0.4	-1.1	-1.2
Change in fecal boli incidents, locomotor task	1.1	1.1	5.4	2.3	0.7	0.7	0.7	0.7	-0.0	0.2	1.1
Time >=10cm from walls, locomotor time 1	1.2	1.2	3.8	-2.0	-0.6	-1.1	-1.1	-0.6	1.0	1.3	-0.3
Bouts of movement, locomotor time 1	0.8	0.8	3.8	2.0	1.2	0.7	0.7	0.6	-0.4	-0.0	0.2
Total resting periods, locomotor time 1	0.7	0.7	2.6	1.6	1.3	0.7	0.7	0.7	-0.2	0.0	-0.0
Rest time, locomotor task time 1	0.2	0.2	0.9	-1.0	-0.0	-0.3	-0.3	-0.2	0.3	0.6	-0.2
Distance moved, locomotor task time 1	0.3	0.3	1.8	-0.4	-0.1	0.4	0.4	0.6	-0.3	-0.1	1.3
Vertical activity count, locomotor time 1	2.7	2.8	13.9	3.7	0.7	1.2	1.2	0.9	-0.9	-1.2	1.3
Time >=10cm from walls, locomotor time 2	0.3	0.3	1.1	-1.0	0.1	0.4	0.4	0.6	-0.4	-0.2	0.9
Bouts of movement, locomotor time 2	1.4	1.5	4.0	-1.0	2.0	1.3	1.3	1.3	-1.4	0.5	-0.4
Total resting periods, locomotor time 2	1.5	1.6	3.8	-1.0	1.9	1.4	1.3	1.4	-1.4	0.5	-0.2
Rest time, locomotor task time 2	1.3	1.5	4.8	2.2	0.6	1.0	0.9	0.7	-1.6	-1.3	0.4
Distance moved, locomotor task time 2	0.9	1.1	2.8	-1.7	-0.7	-0.4	-0.4	-0.0	1.4	0.9	1.5
Vertical activity count, locomotor time 2	0.2	0.2	0.5	0.7	0.3	0.1	0.2	0.2	0.7	0.3	0.5
Light reinforcement 1	0.2	0.4	1.4	-1.2	-0.6	-0.4	-0.4	-0.2	-0.2	0.5	0.7
Light reinforcement 2	0.2	0.3	1.1	-1.1	-0.3	-0.5	-0.5	-0.4	0.3	0.8	-0.2
Bone: marrow area	0.0	0.0	0.2	-0.3	0.0	0.0	0.0	0.1	0.1	0.4	0.3
Bone: maximum diameter	0.9	1.7	2.7	0.5	-1.6	-1.6	-1.5	-1.7	1.4	1.0	-0.8
Bone: maximum force	0.2	0.3	0.8	0.9	-0.4	-0.5	-0.4	-0.6	0.8	0.2	-0.4
Bone: maximum moment	0.2	0.4	1.2	1.1	-0.5	-0.5	-0.4	-0.6	0.8	0.0	-0.4
Mean time between licks in bursts	0.4	0.6	1.6	1.3	0.4	0.7	0.7	0.5	-0.2	-1.1	0.2
Mean num. licks in bursts	1.6	1.9	3.3	0.4	1.2	1.6	1.6	1.5	-1.8	-1.2	1.4
Cd content in liver	0.5	0.5	1.5	0.8	-0.2	-0.4	-0.4	-0.7	1.2	0.3	-1.1
Co content in liver	1.2	1.4	2.2	0.4	1.5	1.4	1.4	1.3	-1.2	-1.0	0.7
Cu content in liver	0.5	0.6	3.2	0.4	-0.0	-0.4	-0.3	-0.6	0.5	-0.6	-1.8
Fe content in liver	1.1	1.4	2.3	-1.2	-1.0	-1.2	-1.3	-1.0	1.3	1.5	-0.6
K content in liver	0.8	0.8	1.5	0.1	0.4	0.8	0.8	0.9	-1.1	-1.1	1.2
Mg content in liver	0.8	0.8	3.2	0.7	0.4	0.7	0.8	0.7	-0.9	-1.8	0.5
Mn content in liver	2.3	2.6	7.2	0.2	-0.2	1.2	1.2	1.4	-1.8	-2.3	2.7
Na content in liver	0.5	0.6	1.3	0.2	0.6	0.7	0.7	0.8	-0.8	-0.7	1.2
Rb content in liver	0.7	0.8	1.5	-1.2	-0.5	-0.9	-0.8	-0.8	1.2	1.2	-0.2
Se content in liver	0.5	0.6	1.8	0.4	-0.2	0.5	0.5	0.6	-0.6	-1.3	1.2
Sr content in liver	1.2	1.1	5.7	2.4	0.1	0.5	0.5	0.4	-0.7	-0.9	1.0
Zn content in liver	0.6	0.6	2.2	-0.7	-0.5	-0.8	-0.8	-0.9	0.2	0.3	-1.5
Bone: minimum diameter	0.4	0.7	1.6	1.3	-0.7	-0.7	-0.7	-0.8	1.2	0.2	-0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.8	-0.6	-0.5	-0.5	-0.5	0.3	0.5	0.1
Time in novel zone, hab. session 1	0.5	0.5	1.2	-1.1	-0.8	-0.6	-0.6	-0.7	0.6	0.0	-0.5
Total zone transitions, hab. session 1	0.4	0.5	0.9	0.3	-0.9	-0.9	-0.9	-0.9	0.7	0.6	-0.3
Total locomotion distance, hab. session 1	0.4	0.6	3.3	1.8	0.7	0.6	0.5	0.2	-0.1	-0.6	-0.2
Locomotion velocity, hab. session 1	0.6	0.9	3.5	1.9	1.2	0.8	0.8	0.5	-0.3	-0.7	-0.4
Time in familiar zone, hab. session 2	1.6	1.6	2.7	-1.0	-0.9	-1.2	-1.3	-1.4	1.1	1.5	-1.6
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.4	0.0	0.1	0.1	0.1	0.1	-0.5	0.3
Total zone transitions, hab. session 2	0.2	0.2	0.8	0.9	-0.6	-0.2	-0.2	-0.3	0.3	-0.4	0.5
Total locomotion distance, hab. session 2	0.9	1.1	4.5	2.1	1.0	1.0	1.0	0.6	-0.2	-1.2	0.1
Locomotion velocity, hab. session 2	0.9	1.2	4.7	2.2	0.9	0.9	0.9	0.7	-0.3	-1.2	0.3
Novel to familiar place preference ratio	0.9	0.9	1.8	0.4	-1.3	-1.1	-1.1	-1.2	0.9	0.5	-0.6
Novelty place preference	0.7	0.7	1.7	0.2	-1.3	-1.0	-1.0	-1.1	0.8	0.5	-0.4
Time in novel zone, NPP test	1.0	1.0	2.3	0.1	-1.5	-1.2	-1.2	-1.3	0.9	0.5	-0.6
Total zone transitions, NPP test	0.2	0.3	0.9	0.5	-0.3	-0.5	-0.5	-0.5	0.9	0.5	-0.1
Total locomotion distance, NPP test	0.7	1.0	2.2	1.2	-0.5	-0.8	-0.8	-1.1	1.5	0.3	-1.1
Locomotion velocity, NPP test	0.5	0.7	2.0	1.4	-0.3	-0.5	-0.6	-0.8	1.3	0.2	-0.9
Intraocular pressure	0.9	1.2	2.3	-1.2	-0.6	-1.1	-1.1	-1.0	1.3	0.8	-1.5
Delta distance traveled before/after self-admin	1.1	1.2	3.2	-0.2	1.8	1.3	1.4	1.3	-0.8	-0.3	0.3
Delta ambulatory time before/after self-admin	0.6	0.6	1.4	-0.0	1.2	1.0	1.0	1.0	-0.7	-0.5	0.4
Parametrial fat weight	0.6	1.1	5.4	2.3	0.3	0.6	0.6	0.2	-0.4	-1.5	0.2
Pavlov. Cond. lever latency	0.3	0.4	1.3	0.9	0.2	-0.0	0.1	-0.4	0.8	-0.2	-1.2
Pavlov. Cond. magazine entry latency	0.6	0.8	1.4	-0.3	-0.7	-0.9	-0.9	-1.0	1.2	1.0	-0.8
Pavlov. Cond. change in total contacts	0.8	0.8	1.4	-0.5	0.8	0.9	0.9	1.2	-1.2	-0.2	1.1
Pavlov. Cond. index score	0.1	0.2	0.6	-0.5	-0.4	-0.2	-0.2	0.0	-0.2	0.3	0.8
Pavlov. Cond. latency score	0.2	0.3	1.2	-0.5	0.0	0.1	0.1	0.4	-0.5	0.3	1.1
Pavlov. Cond. lever contacts	0.3	0.4	1.2	-1.1	-0.4	-0.2	-0.3	0.1	-0.4	0.4	1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.2	0.2	0.3	0.3	0.3	-0.5	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	0.2	-0.2	0.4	0.3	0.5	-0.9	-0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.9	-0.3	-0.4	-0.0	-0.1	0.2	-0.4	-0.1	1.0
Pavlov. Cond. response bias	0.8	1.0	1.5	-0.9	-1.2	-1.2	-1.2	-1.1	0.8	0.9	-0.3
Pavlov. Cond. lever latency	0.3	0.4	2.7	-1.6	0.1	0.2	0.2	0.2	-0.8	-0.0	0.2
Pavlov. Cond. magazine entry latency	2.1	2.4	3.4	-0.2	-1.5	-1.7	-1.7	-1.8	1.8	1.5	-1.2
Pavlov. Cond. change in total contacts	0.5	0.7	2.0	1.3	-0.3	-0.6	-0.6	-0.7	1.4	0.3	-0.7
Pavlov. Cond. index score	1.2	1.5	3.3	0.7	-0.9	-1.3	-1.3	-1.4	1.8	1.0	-1.2
Pavlov. Cond. latency score	1.0	1.2	2.9	0.8	-0.8	-1.1	-1.1	-1.2	1.7	0.8	-1.1
Pavlov. Cond. lever contacts	0.8	1.1	2.7	1.0	-0.9	-1.1	-1.0	-1.1	1.6	0.7	-0.7
Pavlov. Cond. magazine entry number	1.9	2.3	4.3	0.0	0.8	1.5	1.5	1.7	-2.1	-1.7	1.8
Pavlov. Cond. intertrial magazine entries	1.3	1.8	4.4	-0.6	0.8	1.2	1.2	1.5	-1.7	-0.9	2.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	3.1	0.7	-1.1	-1.4	-1.4	-1.5	1.8	0.9	-1.2
Pavlov. Cond. response bias	0.8	1.1	2.4	0.6	-0.9	-1.1	-1.1	-1.1	1.5	0.9	-0.7
Time in closed arm before self-admin	1.2	1.3	2.2	-0.7	-1.5	-1.4	-1.3	-1.3	1.1	1.1	-0.4
Time in closed arm after self-admin	1.4	1.5	5.1	-2.3	-0.4	-0.9	-0.8	-0.8	1.1	1.1	-1.4
Time in open arm before self-admin	4.4	4.8	22.9	4.8	1.2	1.5	1.4	0.8	-1.9	-2.3	-0.2
Time in open arm after self-admin	4.4	4.8	6.7	1.9	1.8	2.4	2.4	2.3	-2.2	-2.6	1.9
Bone: periosteal estimation	0.1	0.2	0.5	0.7	-0.4	-0.4	-0.4	-0.5	0.7	0.2	-0.2
Bone: periosteal perimeter	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.5	-0.7	0.7	0.5	-0.6
Bone: post-yield work	0.5	0.6	2.4	-1.5	0.3	-0.2	-0.2	0.0	0.5	1.5	-0.3
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	-0.7	-0.8	-0.2	-0.2	-0.2	-0.0	0.1	0.9
Progressive ratio test 1 breakpoint	0.2	0.2	0.8	-0.2	-0.7	-0.2	-0.1	-0.2	-0.1	0.1	0.9
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.1	-0.2	-1.1	-1.0	-1.0	-0.8	0.6	0.7	0.2
Progressive ratio test 2 active lever presses	1.8	1.9	8.9	-3.0	-0.9	-1.0	-1.0	-1.0	0.6	1.1	-1.1
Progressive ratio test 2 breakpoint	2.1	2.3	10.6	-3.3	-0.8	-1.1	-1.1	-1.0	0.8	1.3	-1.2
Progressive ratio test 2 inactive lever presses	1.2	1.4	6.8	-2.6	-0.4	-0.7	-0.7	-0.5	0.6	1.4	-0.4
Incentive Sensitization - Responses	5.4	5.5	23.0	-4.8	-1.0	-1.8	-1.8	-1.6	1.4	2.1	-2.2
Incentive Sensitization - Breakpoint	6.1	6.3	27.5	-5.2	-1.0	-1.8	-1.8	-1.6	1.5	2.3	-2.3
Sum of active levers in priming session hrs 5-6	1.9	1.8	2.9	-1.3	1.4	1.6	1.6	1.7	-0.8	-0.5	1.4
Progressive ratio	0.2	0.3	0.8	0.9	0.6	0.4	0.4	0.2	0.1	0.6	-0.3
Food seeking constrained by brief footshock	7.9	9.7	13.6	3.7	2.9	3.4	3.4	3.3	-2.7	-2.3	2.9
Seeking ratio, punishment vs. effort	2.4	3.0	3.6	1.7	1.4	1.6	1.6	1.8	-1.9	-1.9	1.9
Retroperitoneal fat weight	0.0	0.1	0.4	0.7	0.2	-0.1	-0.1	-0.0	0.4	0.2	-0.1
Reaction time number correct	3.0	4.3	7.5	2.6	-2.7	-2.3	-2.3	-2.6	0.9	-0.3	-1.2
Reaction time mean minus median	0.4	0.5	1.7	-1.3	-0.3	-0.4	-0.4	-0.4	0.2	1.1	-0.4
Reaction time mean minus median AUC	1.1	1.4	2.1	-1.3	-1.0	-1.2	-1.2	-1.2	0.9	1.4	-1.0
Reaction time num false alarms	2.6	3.6	7.0	-0.4	-2.7	-2.4	-2.4	-2.3	1.4	1.6	-0.8
Reaction time num false alarms AUC	1.8	2.5	5.2	0.7	-2.3	-2.0	-2.0	-1.9	1.0	1.1	-0.5
Reaction time trials correct on left	3.0	4.3	7.5	2.6	-2.7	-2.3	-2.3	-2.6	0.9	-0.3	-1.2
Reaction time trials on left	3.0	4.3	7.5	2.6	-2.7	-2.3	-2.3	-2.6	0.9	-0.4	-1.2
Reaction time mean	0.3	0.4	1.4	-1.2	0.6	0.7	0.7	0.7	-0.1	0.3	0.0
Reaction time mean AUC	0.3	0.3	1.1	-1.0	0.6	0.6	0.6	0.6	-0.2	0.4	0.2
Median of all reaction times	0.5	0.7	1.3	-0.6	1.0	1.1	1.1	1.1	-0.3	-0.3	0.5
Reaction time omissions	0.1	0.1	0.6	0.8	-0.4	-0.3	-0.3	-0.2	0.2	-0.4	0.1
Reaction time false alarm rate	0.3	0.5	1.6	-1.0	-0.5	-0.5	-0.6	-0.3	0.4	1.3	0.1
Reaction time premature initiation rate	0.9	1.2	4.8	-2.2	0.8	0.9	0.9	1.0	-0.9	-0.3	0.5
Reaction time premature initiations	0.1	0.2	0.3	-0.5	-0.5	-0.3	-0.3	-0.4	-0.3	-0.5	-0.2
Std. dev. reaction times	0.2	0.3	1.6	-1.2	0.0	-0.0	-0.0	0.1	0.0	0.7	-0.2
Reaction time trials completed	3.0	4.3	7.5	2.6	-2.7	-2.3	-2.3	-2.6	0.9	-0.4	-1.2
Reaction time trials AUC	3.4	4.9	9.1	2.6	-3.0	-2.5	-2.5	-2.8	1.1	-0.3	-1.3
Run reversals in cocaine runway, females	1.4	1.3	2.8	-1.6	0.2	-0.9	-0.9	-0.5	1.7	1.5	-1.1
Run reversals in cocaine runway, males	0.2	0.2	0.8	0.0	-0.6	-0.0	-0.1	-0.1	0.2	-0.9	-0.2
Latency to leave start box in cocaine runway	1.7	1.8	3.4	-1.9	-0.8	-1.2	-1.2	-1.1	1.4	1.7	-1.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.9	-0.1	-0.8	-0.8	-0.8	-0.9	0.4	0.4	-0.9
Latency to leave start box in cocaine runway, M	4.4	4.2	14.1	-3.8	-1.0	-1.5	-1.6	-1.0	1.9	3.0	-0.3
Std. dev. time between licks in bursts	0.1	0.1	0.5	0.3	-0.2	-0.0	-0.0	0.1	-0.1	0.4	0.7
Total sessions with >9 infusions	2.3	2.6	12.8	-3.6	-1.9	-1.0	-1.0	-1.0	0.7	0.9	0.1
Short access day 1 total inactive lever presses	5.4	6.1	29.8	-5.5	-1.5	-1.6	-1.6	-1.2	2.0	2.3	-0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.9	-0.9	0.5	-0.3	-0.3	-0.0	0.5	0.7	-0.6
Short access day 1 total infusions	0.9	0.9	5.7	-2.4	-0.8	-0.2	-0.2	-0.1	0.3	0.4	0.9
Short access day 10 total infusions	1.0	1.1	3.3	-0.3	-1.8	-1.2	-1.2	-1.3	0.5	0.5	-0.0
Short access total infusions	0.2	0.3	1.0	-1.0	-0.6	-0.2	-0.2	-0.1	-0.0	0.2	0.8
Short access day 1 locomotion	0.5	0.6	1.9	-1.4	-1.0	-0.6	-0.6	-0.7	0.4	0.3	-0.1
Short access day 10 total locomotion	0.1	0.1	0.6	0.8	-0.2	0.1	0.1	-0.1	-0.3	-0.3	0.2
Short access total locomotion	0.3	0.3	1.3	-0.3	-0.3	0.4	0.5	0.4	-0.6	-0.5	1.1
One hour access (0.3 mA shock)	6.8	8.0	54.3	-7.4	-0.5	-0.9	-0.9	-0.5	1.0	2.4	-0.7
Compulsive drug intake	1.9	1.9	14.3	-3.8	-0.0	0.2	0.2	0.4	0.3	0.7	0.5
One hour access (shock baseline)	5.6	6.5	30.2	-5.5	-1.9	-1.9	-1.9	-1.7	1.4	2.2	-1.1
Social response proportion	0.7	0.8	2.2	0.4	-1.5	-1.1	-1.1	-1.0	0.0	0.7	0.1
Social responses	1.1	1.4	5.4	-2.3	-1.2	-0.8	-0.9	-0.5	-0.1	1.5	0.6
Social time	1.2	1.6	4.2	0.6	2.0	1.6	1.5	1.5	-1.0	-0.1	0.2
Soleus weight	1.4	4.0	8.5	0.3	-0.9	-2.0	-1.9	-2.2	2.6	1.8	-2.9
Bone: stiffness	0.8	1.3	1.9	-0.2	-1.1	-1.3	-1.3	-1.4	1.3	1.0	-1.0
Tibialis anterior weight	2.9	9.9	15.7	1.3	-3.4	-3.6	-3.6	-4.0	3.4	1.7	-3.1
Time to tail flick, vehicle, before self-admin	0.8	0.9	2.8	1.7	-1.3	-0.5	-0.4	-0.5	0.1	-0.9	1.0
Time to tail flick, vehicle, after self-admin	4.5	4.8	9.6	-3.1	-1.4	-2.1	-2.2	-1.8	2.2	2.7	-1.6
Time to tail flick, test, before self-admin	6.8	6.7	10.3	3.2	1.5	2.5	2.5	2.3	-2.8	-3.0	2.4
Time to tail flick, test, after self-admin	0.2	0.2	1.0	0.4	-0.1	0.4	0.4	0.3	-0.6	-0.2	1.0
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	4.3	-2.1	-0.5	-1.1	-1.2	-0.9	0.8	1.7	-1.2
Delta time to tail flick, test, before/after SA	2.3	2.1	2.6	-1.3	-1.6	-1.6	-1.6	-1.5	1.5	1.5	-0.7
Tibia length	0.0	0.1	0.4	0.0	-0.6	-0.3	-0.3	-0.1	-0.0	-0.2	0.6
Ambulatory time before self-admin	1.3	1.3	9.3	3.0	0.1	0.2	0.2	-0.2	-0.3	-0.9	-0.3
Ambulatory time after self-admin	1.6	1.8	6.9	2.6	1.3	1.2	1.2	0.9	-0.8	-1.0	0.3
Bone: tissue strength	0.7	0.7	3.1	1.8	0.5	0.7	0.7	0.6	-0.6	-0.8	0.2
Total heroin consumption	0.5	0.6	1.8	1.3	0.7	0.8	0.8	0.7	-0.2	0.1	0.9
Bone: trabecular number	0.1	0.1	0.2	0.5	0.4	0.2	0.1	0.3	0.0	0.2	0.4
Bone: trabecular spacing	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.1	-0.3	-0.0	-0.3	-0.4
Bone: trabecular thickness	0.5	0.6	1.1	0.3	-1.1	-0.9	-1.0	-0.9	1.0	0.2	-0.3
Bone: trabecular tissue density	0.8	1.1	3.4	-0.1	-1.0	-1.0	-0.9	-1.3	0.8	-0.3	-1.8
Water consumed over 24 hours	0.9	1.0	3.2	0.5	0.3	0.9	0.9	1.0	-1.0	-1.0	1.8
Number of responses in last shaping day	3.8	3.9	13.8	-3.7	-2.0	-1.7	-1.7	-1.7	1.4	1.4	-1.0