Hub : Genes

Zzef1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Zzef1 0.28 0.16 2.6e-03 0.02 0.03 0.02 0.02 1.1e-01 8.6e-02 9.5e-02 1.1e-01
2 BLA alternative TSS XM_039087336.1 0.05 0.04 6.6e-03 0.03 0.04 0.04 0.03 1.4e-02 4.3e-03 4.6e-03 9.0e-03
3 RMTg gene expression Zzef1 0.23 0.13 1.1e-05 0.15 0.1 0.18 0.09 7.9e-05 1.4e-03 1.9e-05 2.3e-03
4 Brain gene expression Zzef1 0.36 0.15 0.0e+00 0.32 0.33 0.33 0.33 1.9e-30 7.5e-32 1.1e-31 6.0e-32
5 NAcc gene expression Zzef1 0.06 0.04 5.3e-06 0.05 0.04 0.05 0.04 2.1e-06 1.3e-05 3.6e-06 5.7e-06
6 OFC gene expression Zzef1 0.29 0.17 1.7e-03 0.07 0.08 0.09 0.09 1.2e-02 5.4e-03 4.6e-03 3.3e-03
7 NAcc intron excision ratio chr10_57487113_57488694 0.02 0.02 4.8e-03 0.02 0.01 0 0.01 3.5e-03 1.8e-02 1.4e-01 1.4e-02
8 PL gene expression Zzef1 0.26 0.14 0.0e+00 0.22 0.21 0.22 0.22 4.1e-24 3.7e-23 1.7e-23 8.4e-24
9 BLA gene expression Zzef1 0.13 0.09 3.1e-05 0.05 0.07 0.07 0.07 1.4e-03 2.0e-04 1.8e-04 1.3e-04
10 pVTA gene expression Zzef1 0.2 0.11 4.7e-09 0.2 0.21 0.18 0.13 4.9e-09 1.4e-09 2.6e-08 4.5e-06
11 Brain intron excision ratio chr10_57495438_57498677 0.04 0.03 4.9e-03 0.02 0.01 0.01 0.02 6.8e-03 2.4e-02 1.5e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.40.73.3-0.10.0-0.20.7-0.70.70.7-0.70.70.91.8
Area under the delay curve0.00.00.30.20.2-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.6
BMI with tail0.20.81.00.80.8-0.80.9-0.91.01.0-1.01.01.00.8
BMI without tail0.51.01.60.80.9-1.11.0-1.01.01.0-1.01.01.21.1
Body weight0.62.49.10.30.5-0.91.4-1.51.51.5-1.51.51.83.0
Weight adjusted by age3.13.54.02.02.0-1.91.9-1.91.91.9-1.91.92.00.7
Bone surface1.12.02.41.11.2-1.31.5-1.51.51.5-1.51.51.51.1
Bone volume1.62.73.21.31.4-1.61.8-1.81.81.8-1.81.81.81.1
Breakpoint value in progressive ratio session0.50.62.30.50.5-0.50.5-0.60.50.5-0.50.51.11.5
Number of licking bursts0.30.30.4-0.5-0.50.5-0.60.6-0.6-0.60.6-0.6-0.6-0.3
Context. condit. distance diff. score1.31.61.90.91.0-1.11.3-1.41.41.4-1.41.41.41.2
Locomotion velocity, session 12.22.44.20.91.1-1.31.5-1.61.61.6-1.61.61.92.1
Locomotion distance, session 11.01.21.61.21.2-1.21.1-1.11.11.1-1.11.11.30.5
Locomotion velocity, session 20.20.20.7-0.7-0.70.5-0.30.3-0.3-0.30.3-0.3-0.20.8
Locomotion distance, session 20.20.30.90.20.3-0.40.5-0.50.50.5-0.50.50.71.0
Locomotion velocity, session 32.32.73.4-1.5-1.51.6-1.71.7-1.7-1.71.7-1.7-1.8-1.2
Locomotion distance, session 30.10.20.2-0.5-0.50.5-0.40.4-0.4-0.40.4-0.4-0.5-0.1
Stereotopy head waving bouts, day 30.00.00.0-0.2-0.20.1-0.00.0-0.0-0.00.0-0.0-0.10.2
Stereotopy head waving duration, day 30.20.21.70.60.6-0.40.00.0-0.0-0.00.0-0.0-0.2-1.3
Locomotion velocity, session 70.10.10.10.30.3-0.30.3-0.20.20.2-0.20.20.2-0.1
Locomotion distance, session 70.00.00.0-0.2-0.20.2-0.10.0-0.0-0.00.0-0.0-0.10.1
Stereotopy head waving bouts, day 71.21.41.61.01.1-1.21.2-1.31.31.3-1.31.31.20.7
Stereotopy head waving duration, day 71.41.82.11.11.2-1.31.4-1.41.41.4-1.41.41.40.9
Locomotion velocity, session 81.21.41.61.11.1-1.21.3-1.31.31.3-1.31.31.20.6
Locomotion distance, session 81.72.53.70.91.0-1.31.6-1.71.71.7-1.71.71.81.9
Degree of sensitization distance0.70.70.90.80.8-0.90.9-0.90.90.9-0.90.90.90.5
Degree of sensitization stereotypy1.31.52.00.80.8-1.01.3-1.31.31.3-1.31.31.41.4
Conditioned locomotion0.91.01.4-0.7-0.80.9-1.01.1-1.1-1.11.1-1.1-1.2-1.1
Cocaine response after cond. corrected0.40.51.0-1.0-0.90.8-0.60.6-0.6-0.60.6-0.6-0.40.8
Cocaine response after cond. not corrected0.20.20.7-0.6-0.60.4-0.30.3-0.3-0.30.3-0.3-0.10.8
Cocaine response before conditioning0.91.01.21.01.1-1.11.1-1.01.01.0-1.01.01.10.4
Saline control response0.50.70.80.80.9-0.90.8-0.80.80.8-0.80.80.90.4
Bone: connectivity density0.81.33.30.40.5-0.71.1-1.21.21.2-1.21.21.31.8
Bone: cortical apparent density1.31.72.0-1.1-1.11.2-1.41.4-1.4-1.41.4-1.4-1.4-0.9
Bone: cortical area0.10.21.00.10.00.1-0.40.4-0.4-0.40.4-0.4-0.5-1.0
Bone: cortical porosity1.31.42.8-1.7-1.61.4-1.11.0-1.0-1.01.0-1.0-0.90.9
Bone: cortical porosity1.31.42.6-1.6-1.61.4-1.11.1-1.1-1.11.1-1.1-1.00.6
Bone: cortical thickness2.44.04.7-1.9-1.92.0-2.12.1-2.1-2.12.1-2.1-2.2-1.1
Bone: cortical thickness4.04.76.5-2.5-2.52.4-2.22.2-2.2-2.22.2-2.2-2.10.2
Bone: cortical tissue density1.11.41.7-1.0-1.11.1-1.31.3-1.3-1.31.3-1.3-1.3-0.7
Condit. Reinf. active minus inactive responses0.91.01.7-1.3-1.31.2-1.00.9-0.9-0.90.9-0.9-0.80.5
Condit. Reinf. active-inactive response ratio0.60.61.1-1.0-1.00.9-0.80.8-0.8-0.80.8-0.8-0.70.4
Condit. Reinf. active responses0.60.71.3-1.2-1.11.0-0.80.8-0.8-0.80.8-0.8-0.60.6
Condit. Reinf. inactive responses0.00.00.1-0.2-0.20.2-0.20.2-0.2-0.20.2-0.2-0.2-0.1
Incentive salience index mean1.11.32.5-1.6-1.51.3-1.11.0-1.0-1.01.0-1.0-0.81.0
Condit. Reinf. lever presses1.01.43.2-1.8-1.61.4-0.90.8-0.8-0.80.8-0.8-0.51.8
Condit. Reinf. active minus inactive responses0.40.51.2-1.1-1.00.9-0.60.6-0.6-0.60.6-0.6-0.60.7
Condit. Reinf. active-inactive response ratio0.80.91.4-1.2-1.11.0-0.90.9-0.9-0.90.9-0.9-0.80.4
Condit. Reinf. active responses0.20.20.5-0.7-0.70.6-0.40.3-0.3-0.30.3-0.3-0.30.5
Condit. Reinf. inactive responses0.10.10.10.40.4-0.30.4-0.40.40.4-0.40.40.2-0.3
Condit. Reinf. lever presses0.30.40.9-0.4-0.40.5-0.60.7-0.7-0.70.7-0.7-0.8-0.9
Condit. Reinf. lever reinforcers received0.10.20.4-0.6-0.60.6-0.40.3-0.3-0.30.3-0.3-0.40.3
Conditioned reinforcement - actives1.31.31.81.01.0-1.11.2-1.31.21.2-1.21.21.00.3
Conditioned reinforcement - inactives1.71.92.91.61.6-1.71.4-1.41.31.3-1.31.31.40.3
Conditioned locomotion0.40.40.90.90.9-0.90.6-0.70.60.6-0.60.60.3-0.6
Patch foraging indifference point 0 sec1.72.73.4-1.8-1.81.8-1.71.7-1.7-1.71.7-1.7-1.30.5
Patch foraging indifference point AUC1.21.33.41.81.7-1.50.8-0.90.70.7-0.70.70.9-1.2
Delay disc. indifference point, 0s delay2.22.43.21.71.8-1.81.6-1.51.51.5-1.51.51.60.1
Delay disc. indifference point, 16s delay0.30.30.80.90.8-0.70.4-0.40.40.4-0.40.40.4-0.7
Delay disc. indifference point, 2s delay0.20.20.4-0.3-0.30.4-0.50.5-0.5-0.50.5-0.5-0.5-0.6
Delay disc. indifference point, 24s delay1.00.91.1-1.0-1.01.0-1.01.0-1.0-1.01.0-1.0-0.9-0.2
Delay disc. indifference point, 4s delay0.40.50.70.80.8-0.80.7-0.70.70.7-0.70.70.7-0.0
Delay disc. indifference point, 8s delay0.00.00.00.10.1-0.00.0-0.00.00.0-0.00.0-0.0-0.1
Indifference point function ln k5.17.112.4-3.5-3.43.2-2.62.5-2.5-2.52.5-2.5-2.50.9
Indifference point function log k5.17.112.4-3.5-3.43.2-2.62.5-2.5-2.52.5-2.5-2.50.9
Patch foraging total patch changes 0 sec1.11.82.3-1.5-1.51.5-1.51.4-1.4-1.41.4-1.4-1.10.4
Patch foraging total patch changes 12 sec0.81.02.01.41.4-1.20.9-0.90.80.8-0.80.81.1-0.2
Patch foraging total patch changes 18 sec0.30.41.01.01.0-0.90.4-0.50.40.4-0.40.40.8-0.1
Patch foraging total patch changes 24 sec0.20.20.80.90.8-0.70.1-0.10.00.0-0.00.00.3-0.7
Patch foraging total patch changes 6 sec0.71.02.81.71.6-1.30.6-0.60.60.6-0.60.60.9-0.8
Patch foraging time to switch 0 sec1.62.52.81.61.7-1.71.7-1.71.71.7-1.71.71.60.5
Patch foraging water rate 0 sec0.81.21.7-1.1-1.21.1-1.11.1-1.1-1.11.1-1.1-1.3-0.8
Patch foraging water rate 12 sec0.40.61.00.40.4-0.70.9-1.00.90.9-0.90.90.70.6
Patch foraging water rate 18 sec0.20.31.3-1.0-0.90.6-0.20.1-0.1-0.10.1-0.1-0.21.1
Patch foraging water rate 24 sec0.10.20.30.00.1-0.30.5-0.60.50.5-0.50.5-0.1-0.3
Patch foraging water rate 6 sec0.20.30.7-0.7-0.70.5-0.30.3-0.3-0.30.3-0.3-0.9-0.6
Seeking ratio, delayed vs. immediate footshock0.70.81.0-0.6-0.60.8-0.91.0-1.0-1.01.0-1.0-0.9-0.9
Distance traveled before self-admin0.20.31.00.80.8-0.60.2-0.10.10.1-0.10.10.1-1.0
Distance traveled after self-admin6.27.09.73.13.1-3.02.7-2.62.62.6-2.62.62.5-0.1
Extensor digitorum longus weight4.015.918.24.14.2-4.34.2-4.24.24.2-4.24.24.11.3
Bone: elastic displacement0.30.30.6-0.2-0.20.4-0.60.6-0.6-0.60.6-0.6-0.6-0.8
Bone: elastic work1.41.82.2-1.0-1.11.2-1.51.5-1.5-1.51.5-1.5-1.5-1.1
Bone: endosteal estimation2.75.99.43.13.0-2.82.4-2.32.32.3-2.32.32.3-0.6
Bone: endosteal perimeter3.06.29.43.13.0-2.92.5-2.42.42.4-2.42.42.4-0.4
Epididymis fat weight4.09.312.52.72.9-3.03.1-3.13.13.1-3.13.13.52.5
Delta time in closed arm before/after self-admin0.80.81.61.31.3-1.00.8-0.70.70.7-0.70.71.0-0.4
Delta time in open arm before/after self-admin1.00.91.20.90.9-1.01.0-1.11.01.0-1.01.01.00.7
Diff in mean of infusions in LGA sessions0.20.22.0-0.6-0.50.3-0.1-0.0-0.1-0.10.1-0.10.21.4
Delay discount exponential model param0.10.10.10.10.1-0.20.3-0.30.30.3-0.30.30.30.4
Extinction: sum of active levers before priming1.21.22.80.70.8-0.91.0-1.11.01.0-1.01.01.51.7
Active lever presses in extinction session 61.21.22.11.11.1-1.01.0-1.11.01.0-1.01.01.41.2
Bone: final force0.61.01.21.11.1-1.11.0-1.01.01.0-1.01.01.00.1
Bone: final moment0.61.01.41.21.2-1.11.0-1.01.01.0-1.01.01.0-0.0
Food consumed during 24 hour testing period0.50.61.1-1.0-1.00.9-0.70.6-0.6-0.60.6-0.6-0.60.6
Glucose0.71.04.90.20.00.3-0.80.9-0.9-0.90.9-0.9-1.0-2.2
Heart weight1.11.52.01.31.3-1.31.2-1.21.21.2-1.21.21.40.7
Delay discount hyperbolic model param0.00.00.2-0.0-0.0-0.10.2-0.20.20.2-0.20.20.20.4
Intermittent access intake day 1-15 change0.80.72.61.31.2-1.00.6-0.50.50.5-0.50.50.2-1.6
Intermittent access intake escalation0.70.74.01.11.0-0.90.4-0.30.40.4-0.40.40.0-2.0
Intermittent access intake escalation 20.60.65.40.40.2-0.0-0.20.3-0.3-0.30.3-0.3-0.7-2.3
Intermitt. access day 1 inactive lever presses0.30.31.4-0.1-0.20.1-0.40.5-0.5-0.50.5-0.5-0.8-1.2
Intermitt. access day 15 inactive lever presses0.10.20.3-0.6-0.50.5-0.40.4-0.3-0.30.3-0.3-0.4-0.1
Intermitt. access escalation Index0.90.83.20.20.3-0.60.7-0.80.80.8-0.80.81.11.8
Intermittent access day 1 total infusions2.32.63.01.71.7-1.71.7-1.71.61.6-1.61.61.70.7
Intermittent access day 15 total infusions4.44.98.12.82.8-2.72.2-2.22.12.1-2.12.11.9-0.9
Intermittent access terminal intake (last 3 days)4.24.66.22.52.5-2.32.2-2.22.22.2-2.22.22.10.0
Intermittent access total infusions2.62.93.92.02.0-1.91.8-1.81.71.7-1.71.71.5-0.2
Intermittent access day 1 locomotion2.42.53.11.61.6-1.81.7-1.81.71.7-1.71.71.30.3
Intermittent access day 15 total locomotion1.21.32.41.51.5-1.31.1-1.11.01.0-1.01.00.8-1.0
Intermittent access total locomotion1.11.21.71.01.0-1.21.2-1.31.21.2-1.21.20.7-0.1
Intermittent access standard deviation2.93.16.12.52.3-2.11.5-1.41.41.4-1.41.41.0-2.1
Left kidney weight0.10.20.70.80.8-0.60.3-0.20.20.2-0.20.20.4-0.6
Right kidney weight0.00.10.30.60.5-0.30.2-0.10.10.1-0.10.10.3-0.4
Cocaine induced anxiety2.22.53.6-1.8-1.81.6-1.61.5-1.5-1.51.5-1.5-1.9-0.9
Post-drug Anxiety0.70.81.3-1.1-1.11.0-0.90.8-0.9-0.90.9-0.9-0.9-0.1
Baseline Anxiety0.90.91.61.21.2-0.90.9-0.90.90.9-0.90.91.20.5
Tail length1.13.510.80.60.8-1.41.7-1.81.81.8-1.81.82.43.3
Length with tail0.41.68.3-0.10.1-0.61.0-1.11.11.1-1.11.11.52.9
Length without tail0.51.13.80.20.3-0.51.0-1.11.11.1-1.11.11.21.9
Times rat made contact with spout1.31.51.9-1.4-1.41.4-1.31.3-1.3-1.31.3-1.3-1.10.2
Lifetime Intake4.04.56.02.42.4-2.42.2-2.22.12.1-2.12.11.9-0.2
Liver weight, left0.10.21.6-0.4-0.40.20.2-0.30.30.3-0.30.30.31.3
Liver weight, right0.91.52.00.80.9-1.11.3-1.31.31.3-1.31.31.41.4
Locomotor activity0.81.21.51.01.1-1.11.2-1.21.21.2-1.21.21.10.4
Locomotor testing distance3.45.66.72.52.5-2.62.5-2.52.52.5-2.52.52.10.0
Locomotor testing rearing3.45.38.22.92.8-2.62.3-2.32.22.2-2.22.22.2-0.5
Locomotion in novel chamber0.60.86.11.00.8-0.50.3-0.30.20.2-0.20.2-0.4-2.5
Locomotion in novel chamber post-restriction0.30.40.5-0.6-0.60.7-0.60.7-0.7-0.70.7-0.7-0.7-0.5
Fecal boli incidents, locomotor time 10.40.40.5-0.7-0.70.7-0.60.6-0.6-0.60.6-0.6-0.60.0
Change in fecal boli incidents, locomotor task0.60.60.7-0.9-0.90.8-0.80.8-0.8-0.80.8-0.8-0.8-0.1
Time >=10cm from walls, locomotor time 10.40.40.6-0.7-0.70.8-0.70.7-0.7-0.70.7-0.7-0.60.2
Bouts of movement, locomotor time 10.60.61.1-1.1-1.00.8-0.80.7-0.7-0.70.7-0.7-0.70.4
Total resting periods, locomotor time 11.82.03.0-1.7-1.71.5-1.41.4-1.4-1.41.4-1.4-1.30.3
Rest time, locomotor task time 10.70.80.9-0.8-0.80.8-1.01.0-1.0-1.01.0-1.0-1.0-0.6
Distance moved, locomotor task time 11.21.31.71.31.3-1.21.2-1.21.21.2-1.21.21.20.2
Vertical activity count, locomotor time 11.31.41.51.21.2-1.21.2-1.21.21.2-1.21.21.20.4
Time >=10cm from walls, locomotor time 20.90.91.1-1.0-1.01.0-1.01.0-1.0-1.01.0-1.0-0.9-0.1
Bouts of movement, locomotor time 21.31.41.9-1.4-1.41.3-1.21.2-1.2-1.21.2-1.2-1.10.1
Total resting periods, locomotor time 20.80.91.4-1.2-1.11.0-0.90.9-0.9-0.90.9-0.9-0.90.3
Rest time, locomotor task time 21.11.31.5-1.2-1.21.2-1.21.1-1.1-1.11.1-1.1-1.2-0.3
Distance moved, locomotor task time 21.92.23.51.91.8-1.71.5-1.41.41.4-1.41.41.4-0.6
Vertical activity count, locomotor time 20.80.81.01.01.0-1.00.9-0.90.90.9-0.90.90.9-0.1
Light reinforcement 11.42.53.41.81.8-1.71.6-1.61.61.6-1.61.61.6-0.1
Light reinforcement 20.10.10.30.50.5-0.30.3-0.40.30.3-0.30.30.2-0.5
Bone: marrow area2.75.89.23.03.0-2.82.4-2.32.32.3-2.32.32.3-0.6
Bone: maximum diameter0.50.92.01.41.3-1.10.8-0.70.70.7-0.70.70.7-0.9
Bone: maximum force0.61.11.51.21.2-1.21.0-1.01.01.0-1.01.01.0-0.0
Bone: maximum moment0.71.21.81.41.3-1.31.1-1.01.01.0-1.01.01.0-0.3
Mean time between licks in bursts1.92.63.11.31.4-1.51.7-1.81.81.8-1.81.81.71.2
Mean num. licks in bursts0.00.00.2-0.3-0.20.3-0.10.1-0.1-0.10.1-0.10.00.4
Cd content in liver1.21.31.61.21.2-1.21.2-1.21.21.2-1.21.21.30.7
Co content in liver0.30.30.30.50.5-0.50.6-0.60.60.6-0.60.60.60.3
Cu content in liver2.83.44.5-2.1-2.12.1-1.91.9-1.9-1.91.9-1.9-1.8-0.0
Fe content in liver0.10.21.3-0.4-0.30.20.1-0.20.20.2-0.20.20.31.1
K content in liver0.10.11.1-0.3-0.20.10.2-0.20.20.2-0.20.20.31.0
Mg content in liver0.00.00.10.10.1-0.0-0.00.1-0.1-0.10.1-0.1-0.1-0.3
Mn content in liver1.31.52.4-1.6-1.51.4-1.21.2-1.2-1.21.2-1.2-1.10.5
Na content in liver0.00.10.40.30.3-0.1-0.00.1-0.1-0.10.1-0.1-0.1-0.6
Rb content in liver0.81.01.31.11.1-1.11.1-1.01.01.0-1.01.01.0-0.0
Se content in liver1.21.51.8-1.1-1.21.2-1.31.3-1.3-1.31.3-1.3-1.3-0.6
Sr content in liver2.11.92.21.31.4-1.51.5-1.51.51.5-1.51.51.40.5
Zn content in liver0.20.20.3-0.4-0.40.5-0.50.5-0.5-0.50.5-0.5-0.5-0.4
Bone: minimum diameter1.93.65.12.32.2-2.11.9-1.91.91.9-1.91.91.8-0.2
Time in familiar zone, hab. session 10.10.10.30.40.4-0.30.2-0.10.10.1-0.10.10.0-0.6
Time in novel zone, hab. session 10.20.20.5-0.7-0.70.6-0.40.3-0.3-0.30.3-0.3-0.30.5
Total zone transitions, hab. session 14.76.69.13.03.0-2.92.6-2.62.62.6-2.62.62.50.0
Total locomotion distance, hab. session 10.40.50.60.70.7-0.70.8-0.70.70.7-0.70.70.80.3
Locomotion velocity, hab. session 10.40.60.80.90.9-0.90.8-0.80.80.8-0.80.80.80.1
Time in familiar zone, hab. session 20.10.10.3-0.5-0.40.4-0.20.2-0.2-0.20.2-0.2-0.10.5
Time in novel zone, hab. session 20.30.30.6-0.4-0.40.5-0.60.6-0.6-0.60.6-0.6-0.7-0.8
Total zone transitions, hab. session 22.73.54.12.02.0-2.01.9-1.91.91.9-1.91.92.00.7
Total locomotion distance, hab. session 20.50.60.80.90.9-0.80.8-0.80.80.8-0.80.80.90.4
Locomotion velocity, hab. session 20.50.70.90.91.0-0.90.8-0.80.80.8-0.80.80.90.3
Novel to familiar place preference ratio0.00.00.30.30.2-0.20.1-0.00.00.0-0.00.0-0.0-0.5
Novelty place preference0.00.00.00.00.0-0.00.0-0.00.00.0-0.00.0-0.1-0.2
Time in novel zone, NPP test0.00.00.0-0.0-0.0-0.00.1-0.10.10.1-0.10.1-0.00.0
Total zone transitions, NPP test3.24.66.02.42.4-2.42.2-2.12.12.1-2.12.12.20.4
Total locomotion distance, NPP test0.20.20.60.80.8-0.70.4-0.30.30.3-0.30.30.4-0.5
Locomotion velocity, NPP test0.10.21.00.60.6-0.40.00.0-0.0-0.00.0-0.0-0.0-1.0
Intraocular pressure1.01.43.01.71.6-1.31.0-0.90.90.9-0.90.90.8-1.5
Delta distance traveled before/after self-admin4.54.95.92.02.0-2.22.4-2.42.42.4-2.42.42.31.2
Delta ambulatory time before/after self-admin2.93.24.01.51.6-1.82.0-2.02.02.0-2.02.01.81.0
Parametrial fat weight12.624.631.04.24.4-4.85.2-5.45.25.2-5.25.25.63.9
Pavlov. Cond. lever latency2.12.73.92.01.9-1.81.7-1.61.61.6-1.61.61.4-0.5
Pavlov. Cond. magazine entry latency2.83.66.1-2.5-2.42.2-1.91.8-1.8-1.81.8-1.8-1.51.0
Pavlov. Cond. change in total contacts2.72.93.3-1.7-1.71.8-1.81.8-1.8-1.81.8-1.8-1.6-0.4
Pavlov. Cond. index score1.82.34.1-2.0-1.91.8-1.51.4-1.4-1.41.4-1.4-1.11.0
Pavlov. Cond. latency score1.92.54.5-2.1-2.01.8-1.51.4-1.4-1.41.4-1.4-1.11.2
Pavlov. Cond. lever contacts1.41.72.6-1.6-1.61.5-1.31.3-1.3-1.31.3-1.3-1.00.6
Pavlov. Cond. magazine entry number1.72.13.11.71.7-1.61.5-1.41.41.4-1.41.41.2-0.4
Pavlov. Cond. intertrial magazine entries2.83.45.12.32.2-2.11.9-1.81.81.8-1.81.81.7-0.4
Pavlov. Cond. lever-magazine prob. diff.1.82.23.8-1.9-1.91.7-1.51.4-1.4-1.41.4-1.4-1.20.9
Pavlov. Cond. response bias1.92.33.5-1.9-1.81.7-1.51.5-1.5-1.51.5-1.5-1.20.7
Pavlov. Cond. lever latency1.92.63.31.21.3-1.61.7-1.71.71.7-1.71.71.81.4
Pavlov. Cond. magazine entry latency1.11.31.5-1.2-1.21.2-1.21.2-1.2-1.21.2-1.2-1.2-0.5
Pavlov. Cond. change in total contacts0.91.21.5-1.0-1.11.1-1.21.2-1.2-1.21.2-1.2-1.2-0.7
Pavlov. Cond. index score1.21.52.3-0.8-0.91.1-1.21.3-1.3-1.31.3-1.3-1.4-1.5
Pavlov. Cond. latency score1.31.73.1-0.7-0.91.1-1.31.3-1.3-1.31.3-1.3-1.5-1.8
Pavlov. Cond. lever contacts0.60.81.1-0.6-0.70.9-0.90.9-0.9-0.90.9-0.9-1.1-1.0
Pavlov. Cond. magazine entry number0.80.91.30.80.9-0.91.0-1.01.01.0-1.01.01.10.8
Pavlov. Cond. intertrial magazine entries1.11.41.61.01.0-1.21.3-1.31.31.3-1.31.31.30.8
Pavlov. Cond. lever-magazine prob. diff.1.21.62.2-0.8-0.91.1-1.31.3-1.3-1.31.3-1.3-1.5-1.5
Pavlov. Cond. response bias1.01.41.7-0.9-1.01.2-1.21.2-1.2-1.21.2-1.2-1.3-1.0
Time in closed arm before self-admin0.40.52.5-1.1-1.00.7-0.20.3-0.2-0.20.2-0.2-0.21.6
Time in closed arm after self-admin0.00.00.1-0.3-0.30.2-0.20.3-0.2-0.20.2-0.2-0.20.1
Time in open arm before self-admin1.31.43.8-0.4-0.50.8-1.21.2-1.3-1.31.3-1.3-1.2-2.0
Time in open arm after self-admin0.40.41.41.11.0-0.70.4-0.50.30.3-0.30.30.2-1.2
Bone: periosteal estimation1.12.34.22.12.0-1.81.4-1.41.41.4-1.41.41.3-0.8
Bone: periosteal perimeter0.71.22.21.51.4-1.31.0-1.01.01.0-1.01.00.9-0.6
Bone: post-yield work0.50.71.20.40.5-0.60.9-0.90.90.9-0.90.90.91.1
Progressive ratio test 1 active lever presses1.61.72.11.21.3-1.21.3-1.31.31.3-1.31.31.40.9
Progressive ratio test 1 breakpoint2.22.33.21.41.5-1.41.5-1.61.51.5-1.51.51.81.4
Progressive ratio test 1 inactive lever presses1.41.51.91.31.3-1.41.3-1.31.31.3-1.31.30.9-0.2
Progressive ratio test 2 active lever presses1.01.01.21.01.0-1.01.1-1.11.11.1-1.11.11.00.5
Progressive ratio test 2 breakpoint0.50.60.80.70.7-0.70.9-0.90.90.9-0.90.90.70.5
Progressive ratio test 2 inactive lever presses2.22.53.01.71.7-1.71.7-1.61.71.7-1.71.71.40.1
Incentive Sensitization - Responses0.20.20.30.20.2-0.40.5-0.50.50.5-0.50.50.30.4
Incentive Sensitization - Breakpoint0.20.20.20.20.3-0.40.5-0.50.50.5-0.50.50.30.4
Sum of active levers in priming session hrs 5-60.50.54.3-0.3-0.1-0.10.3-0.50.30.3-0.30.30.82.1
Progressive ratio0.40.51.21.11.1-0.80.6-0.60.60.6-0.60.60.7-0.2
Food seeking constrained by brief footshock0.20.20.4-0.2-0.20.3-0.50.5-0.5-0.50.5-0.5-0.4-0.6
Seeking ratio, punishment vs. effort0.91.11.9-1.4-1.41.2-1.01.0-1.0-1.01.0-1.0-1.1-0.2
Retroperitoneal fat weight0.10.50.90.90.9-0.80.6-0.60.60.6-0.60.60.5-0.6
Reaction time number correct0.10.20.3-0.2-0.1-0.10.5-0.50.60.6-0.60.60.10.6
Reaction time mean minus median0.71.01.3-0.5-0.60.9-1.11.0-1.1-1.11.1-1.1-1.0-1.0
Reaction time mean minus median AUC0.20.20.4-0.1-0.20.4-0.50.4-0.5-0.50.5-0.5-0.4-0.6
Reaction time num false alarms1.31.82.4-1.2-1.21.4-1.41.5-1.4-1.41.4-1.4-1.4-1.0
Reaction time num false alarms AUC1.01.41.8-1.0-1.01.2-1.21.3-1.2-1.21.2-1.2-1.3-1.0
Reaction time trials correct on left0.10.20.3-0.2-0.1-0.10.5-0.50.60.6-0.60.60.10.6
Reaction time trials on left0.10.20.3-0.2-0.1-0.10.5-0.50.60.6-0.60.60.10.5
Reaction time mean0.30.40.6-0.4-0.40.6-0.80.7-0.8-0.80.8-0.8-0.6-0.6
Reaction time mean AUC0.70.91.2-0.5-0.60.8-1.11.0-1.1-1.11.1-1.1-0.9-1.0
Median of all reaction times0.10.20.2-0.1-0.10.3-0.40.4-0.5-0.50.5-0.5-0.3-0.5
Reaction time omissions0.30.40.80.90.8-0.70.6-0.70.60.6-0.60.60.6-0.3
Reaction time false alarm rate0.91.31.8-0.8-0.81.1-1.21.3-1.3-1.31.3-1.3-1.1-1.0
Reaction time premature initiation rate1.41.83.6-1.9-1.81.6-1.31.1-1.2-1.21.2-1.2-1.20.7
Reaction time premature initiations0.91.33.2-1.8-1.71.4-0.90.7-0.8-0.80.8-0.8-1.00.9
Std. dev. reaction times1.52.12.6-1.1-1.21.4-1.61.5-1.6-1.61.6-1.6-1.5-1.0
Reaction time trials completed0.10.20.3-0.2-0.1-0.10.5-0.50.60.6-0.60.60.10.5
Reaction time trials AUC0.10.10.2-0.2-0.2-0.10.4-0.40.50.5-0.50.50.10.5
Run reversals in cocaine runway, females0.10.10.3-0.3-0.30.3-0.30.3-0.3-0.30.3-0.3-0.5-0.5
Run reversals in cocaine runway, males1.51.42.71.61.6-1.41.1-1.01.01.0-1.01.00.8-1.2
Latency to leave start box in cocaine runway0.10.10.2-0.2-0.20.3-0.40.4-0.4-0.40.4-0.4-0.1-0.0
Latency to leave start box in cocaine runway, F0.10.10.4-0.3-0.20.3-0.30.3-0.3-0.30.3-0.30.20.6
Latency to leave start box in cocaine runway, M0.20.20.30.50.5-0.50.5-0.50.50.5-0.50.50.4-0.0
Std. dev. time between licks in bursts0.60.80.90.70.7-0.90.9-1.01.01.0-1.01.00.90.5
Total sessions with >9 infusions2.93.23.92.02.0-1.91.8-1.91.81.8-1.81.81.80.5
Short access day 1 total inactive lever presses0.10.10.30.30.3-0.50.3-0.40.30.3-0.30.30.30.4
Short access day 10 total inactive lever presses0.20.20.4-0.6-0.60.4-0.30.3-0.3-0.30.3-0.3-0.50.3
Short access day 1 total infusions2.82.95.72.42.3-2.11.6-1.51.51.5-1.51.51.5-0.8
Short access day 10 total infusions1.71.92.41.51.6-1.51.4-1.51.41.4-1.41.41.40.1
Short access total infusions3.94.46.72.62.6-2.42.1-2.12.02.0-2.02.01.9-0.5
Short access day 1 locomotion0.70.81.81.31.3-1.10.8-0.80.70.7-0.70.70.6-0.8
Short access day 10 total locomotion0.60.71.20.90.8-1.10.9-0.90.90.9-0.90.90.4-0.4
Short access total locomotion0.60.61.01.00.9-1.00.8-0.90.80.8-0.80.80.4-0.4
One hour access (0.3 mA shock)1.82.12.61.61.6-1.61.5-1.61.51.5-1.51.51.30.1
Compulsive drug intake0.91.02.2-1.5-1.40.9-0.90.8-0.8-0.80.8-0.8-0.80.9
One hour access (shock baseline)2.63.04.32.12.0-1.81.8-1.81.81.8-1.81.81.6-0.3
Social response proportion1.01.05.6-1.6-1.41.0-0.20.1-0.1-0.10.1-0.1-0.12.4
Social responses2.12.73.51.11.2-1.31.7-1.81.81.8-1.81.81.91.8
Social time1.31.72.60.60.7-0.91.4-1.41.51.5-1.51.51.41.6
Soleus weight2.77.811.11.61.8-2.32.9-3.03.03.0-3.03.03.13.3
Bone: stiffness2.23.54.31.41.5-1.72.0-2.02.02.0-2.02.02.11.7
Tibialis anterior weight4.114.216.53.33.5-3.74.0-4.04.04.0-4.04.04.12.3
Time to tail flick, vehicle, before self-admin0.30.32.9-0.2-0.1-0.10.2-0.20.30.3-0.30.30.61.7
Time to tail flick, vehicle, after self-admin0.10.10.20.40.4-0.40.4-0.40.40.4-0.40.40.3-0.2
Time to tail flick, test, before self-admin3.43.36.0-2.5-2.42.2-1.71.6-1.7-1.71.7-1.7-1.70.7
Time to tail flick, test, after self-admin0.70.71.3-1.2-1.11.0-0.80.9-0.8-0.80.8-0.8-0.80.4
Delta time to tail flick, vehicle, before/after SA0.60.62.61.00.9-0.70.5-0.50.40.4-0.40.40.0-1.6
Delta time to tail flick, test, before/after SA1.41.22.41.61.5-1.31.0-0.91.01.0-1.01.01.1-0.5
Tibia length0.30.82.8-1.4-1.31.1-0.60.5-0.5-0.50.5-0.5-0.31.7
Ambulatory time before self-admin0.10.10.60.50.4-0.2-0.20.2-0.2-0.20.2-0.2-0.1-0.7
Ambulatory time after self-admin3.43.74.52.02.0-2.12.0-2.02.02.0-2.02.02.00.7
Bone: tissue strength0.10.00.30.30.3-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.6
Total heroin consumption1.01.29.6-0.5-0.3-0.10.4-0.60.60.6-0.60.61.03.1
Bone: trabecular number0.20.32.4-0.6-0.50.30.1-0.10.10.1-0.10.10.31.5
Bone: trabecular spacing0.10.11.00.50.4-0.40.1-0.10.10.1-0.10.1-0.1-1.0
Bone: trabecular thickness0.20.20.40.20.2-0.20.4-0.50.50.5-0.50.50.50.7
Bone: trabecular tissue density2.02.83.5-1.2-1.31.5-1.81.9-1.9-1.91.9-1.9-1.8-1.5
Water consumed over 24 hours3.54.36.7-2.6-2.52.4-2.12.0-2.0-2.02.0-2.0-1.80.8
Number of responses in last shaping day0.30.31.70.80.7-0.60.3-0.30.30.3-0.30.3-0.1-1.3