Hub : Genes

Zscan2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Zscan2 0.03 0.02 4.7e-04 0.02 0.02 0.02 0.02 1.3e-03 9.0e-04 1.7e-04 3.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density1.83.23.2-1.8
Area under the delay curve0.20.20.20.5
BMI with tail3.712.712.73.6
BMI without tail1.23.83.81.9
Body weight0.62.82.81.7
Weight adjusted by age1.21.81.8-1.4
Bone surface3.15.75.7-2.4
Bone volume2.64.74.7-2.2
Breakpoint value in progressive ratio session0.30.30.30.6
Number of licking bursts0.91.51.5-1.2
Context. condit. distance diff. score0.91.11.1-1.0
Locomotion velocity, session 10.40.40.40.7
Locomotion distance, session 10.00.00.0-0.1
Locomotion velocity, session 20.30.30.30.6
Locomotion distance, session 20.10.10.1-0.4
Locomotion velocity, session 30.70.80.8-0.9
Locomotion distance, session 30.70.70.7-0.8
Stereotopy head waving bouts, day 32.32.72.7-1.6
Stereotopy head waving duration, day 30.20.30.3-0.5
Locomotion velocity, session 71.31.41.41.2
Locomotion distance, session 70.00.00.00.1
Stereotopy head waving bouts, day 71.21.41.4-1.2
Stereotopy head waving duration, day 70.30.30.3-0.6
Locomotion velocity, session 81.41.71.71.3
Locomotion distance, session 80.71.01.0-1.0
Degree of sensitization distance0.30.30.30.5
Degree of sensitization stereotypy0.10.10.1-0.3
Conditioned locomotion0.00.00.0-0.1
Cocaine response after cond. corrected0.40.40.40.7
Cocaine response after cond. not corrected0.50.60.60.8
Cocaine response before conditioning0.40.50.5-0.7
Saline control response0.10.10.10.3
Bone: connectivity density2.13.33.3-1.8
Bone: cortical apparent density2.43.33.31.8
Bone: cortical area3.55.45.4-2.3
Bone: cortical porosity0.60.60.6-0.8
Bone: cortical porosity0.40.40.4-0.7
Bone: cortical thickness0.30.50.5-0.7
Bone: cortical thickness0.00.00.0-0.0
Bone: cortical tissue density2.43.23.21.8
Condit. Reinf. active minus inactive responses0.40.50.50.7
Condit. Reinf. active-inactive response ratio1.51.61.6-1.3
Condit. Reinf. active responses0.50.70.70.8
Condit. Reinf. inactive responses0.70.80.80.9
Incentive salience index mean2.22.72.71.6
Condit. Reinf. lever presses5.98.28.22.9
Condit. Reinf. active minus inactive responses0.40.50.50.7
Condit. Reinf. active-inactive response ratio0.20.30.30.5
Condit. Reinf. active responses0.30.40.40.6
Condit. Reinf. inactive responses0.10.10.10.3
Condit. Reinf. lever presses0.30.40.40.6
Condit. Reinf. lever reinforcers received0.40.60.60.8
Conditioned reinforcement - actives1.22.12.1-1.4
Conditioned reinforcement - inactives2.84.14.1-2.0
Conditioned locomotion0.40.50.5-0.7
Patch foraging indifference point 0 sec0.30.50.5-0.7
Patch foraging indifference point AUC1.62.32.3-1.5
Delay disc. indifference point, 0s delay0.00.00.0-0.2
Delay disc. indifference point, 16s delay0.10.10.1-0.3
Delay disc. indifference point, 2s delay0.00.00.00.1
Delay disc. indifference point, 24s delay0.00.00.0-0.1
Delay disc. indifference point, 4s delay0.91.01.01.0
Delay disc. indifference point, 8s delay0.60.80.80.9
Indifference point function ln k0.50.90.90.9
Indifference point function log k0.50.90.90.9
Patch foraging total patch changes 0 sec0.50.90.9-1.0
Patch foraging total patch changes 12 sec6.38.18.1-2.9
Patch foraging total patch changes 18 sec3.04.64.6-2.1
Patch foraging total patch changes 24 sec1.42.42.4-1.6
Patch foraging total patch changes 6 sec0.91.41.4-1.2
Patch foraging time to switch 0 sec1.12.22.2-1.5
Patch foraging water rate 0 sec1.02.22.21.5
Patch foraging water rate 12 sec7.215.115.13.9
Patch foraging water rate 18 sec4.06.16.12.5
Patch foraging water rate 24 sec3.24.54.52.1
Patch foraging water rate 6 sec6.79.79.73.1
Seeking ratio, delayed vs. immediate footshock0.40.50.50.7
Distance traveled before self-admin1.21.51.51.2
Distance traveled after self-admin0.60.70.7-0.8
Extensor digitorum longus weight0.41.71.71.3
Bone: elastic displacement3.94.54.52.1
Bone: elastic work1.41.81.81.4
Bone: endosteal estimation6.915.215.2-3.9
Bone: endosteal perimeter4.710.010.0-3.2
Epididymis fat weight2.17.17.12.7
Delta time in closed arm before/after self-admin0.40.40.4-0.6
Delta time in open arm before/after self-admin2.12.12.11.5
Diff in mean of infusions in LGA sessions0.00.00.0-0.0
Delay discount exponential model param0.30.30.3-0.6
Extinction: sum of active levers before priming3.03.33.31.8
Active lever presses in extinction session 63.93.83.82.0
Bone: final force2.54.14.1-2.0
Bone: final moment2.23.53.5-1.9
Food consumed during 24 hour testing period3.14.34.3-2.1
Glucose0.10.10.10.3
Heart weight2.94.54.52.1
Delay discount hyperbolic model param0.30.40.4-0.6
Intermittent access intake day 1-15 change0.40.80.8-0.9
Intermittent access intake escalation0.61.21.2-1.1
Intermittent access intake escalation 21.71.91.9-1.4
Intermitt. access day 1 inactive lever presses0.10.50.50.7
Intermitt. access day 15 inactive lever presses0.40.90.9-0.9
Intermitt. access escalation Index0.10.10.10.4
Intermittent access day 1 total infusions0.10.20.2-0.4
Intermittent access day 15 total infusions0.30.50.5-0.7
Intermittent access terminal intake (last 3 days)0.20.30.3-0.5
Intermittent access total infusions0.00.00.0-0.0
Intermittent access day 1 locomotion0.00.00.0-0.1
Intermittent access day 15 total locomotion0.10.10.10.4
Intermittent access total locomotion0.81.01.0-1.0
Intermittent access standard deviation0.71.41.4-1.2
Left kidney weight0.00.20.2-0.5
Right kidney weight0.00.00.0-0.1
Cocaine induced anxiety1.31.81.8-1.3
Post-drug Anxiety0.20.20.2-0.5
Baseline Anxiety6.27.27.22.7
Tail length0.31.21.2-1.1
Length with tail0.20.80.8-0.9
Length without tail0.00.00.00.1
Times rat made contact with spout1.31.51.51.2
Lifetime Intake0.00.00.00.2
Liver weight, left0.00.00.00.2
Liver weight, right0.00.00.0-0.1
Locomotor activity0.20.30.3-0.6
Locomotor testing distance0.10.10.10.3
Locomotor testing rearing0.00.00.00.1
Locomotion in novel chamber0.00.00.0-0.2
Locomotion in novel chamber post-restriction0.00.00.0-0.0
Fecal boli incidents, locomotor time 10.00.00.0-0.1
Change in fecal boli incidents, locomotor task0.00.00.00.2
Time >=10cm from walls, locomotor time 12.42.62.61.6
Bouts of movement, locomotor time 10.10.10.10.4
Total resting periods, locomotor time 10.10.10.10.3
Rest time, locomotor task time 10.91.11.1-1.0
Distance moved, locomotor task time 10.50.70.70.8
Vertical activity count, locomotor time 10.00.00.00.1
Time >=10cm from walls, locomotor time 20.00.00.0-0.1
Bouts of movement, locomotor time 23.86.06.0-2.5
Total resting periods, locomotor time 24.17.37.3-2.7
Rest time, locomotor task time 21.41.81.8-1.3
Distance moved, locomotor task time 20.00.00.0-0.1
Vertical activity count, locomotor time 20.10.10.1-0.3
Light reinforcement 14.912.012.0-3.5
Light reinforcement 22.23.43.4-1.8
Bone: marrow area7.115.515.5-3.9
Bone: maximum diameter5.911.011.0-3.3
Bone: maximum force2.34.04.0-2.0
Bone: maximum moment1.93.33.3-1.8
Mean time between licks in bursts0.82.12.1-1.4
Mean num. licks in bursts3.25.05.02.2
Cd content in liver0.20.20.2-0.5
Co content in liver0.10.10.1-0.4
Cu content in liver0.10.10.10.4
Fe content in liver0.00.10.1-0.2
K content in liver0.40.40.4-0.6
Mg content in liver1.21.31.3-1.1
Mn content in liver0.00.00.00.2
Na content in liver0.50.50.5-0.7
Rb content in liver0.60.60.6-0.8
Se content in liver0.00.00.00.0
Sr content in liver0.10.10.1-0.2
Zn content in liver1.51.71.7-1.3
Bone: minimum diameter7.413.513.5-3.7
Time in familiar zone, hab. session 10.00.00.0-0.2
Time in novel zone, hab. session 10.40.40.40.6
Total zone transitions, hab. session 10.60.80.80.9
Total locomotion distance, hab. session 10.60.80.8-0.9
Locomotion velocity, hab. session 10.50.70.7-0.8
Time in familiar zone, hab. session 21.81.91.9-1.4
Time in novel zone, hab. session 21.11.11.11.0
Total zone transitions, hab. session 20.10.10.10.3
Total locomotion distance, hab. session 22.43.13.1-1.8
Locomotion velocity, hab. session 21.72.22.2-1.5
Novel to familiar place preference ratio0.60.70.7-0.8
Novelty place preference0.50.50.5-0.7
Time in novel zone, NPP test0.10.10.1-0.4
Total zone transitions, NPP test0.20.30.30.6
Total locomotion distance, NPP test1.42.02.0-1.4
Locomotion velocity, NPP test2.12.92.9-1.7
Intraocular pressure0.00.00.00.0
Delta distance traveled before/after self-admin6.16.56.5-2.5
Delta ambulatory time before/after self-admin2.83.43.4-1.8
Parametrial fat weight2.45.65.62.4
Pavlov. Cond. lever latency2.32.82.8-1.7
Pavlov. Cond. magazine entry latency2.63.33.31.8
Pavlov. Cond. change in total contacts0.90.90.91.0
Pavlov. Cond. index score2.83.53.51.9
Pavlov. Cond. latency score2.83.63.61.9
Pavlov. Cond. lever contacts1.72.02.01.4
Pavlov. Cond. magazine entry number3.13.93.9-2.0
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.3
Pavlov. Cond. lever-magazine prob. diff.3.24.04.02.0
Pavlov. Cond. response bias1.31.61.61.3
Pavlov. Cond. lever latency1.31.81.8-1.3
Pavlov. Cond. magazine entry latency3.34.04.02.0
Pavlov. Cond. change in total contacts1.82.82.81.7
Pavlov. Cond. index score2.93.93.92.0
Pavlov. Cond. latency score2.33.03.01.7
Pavlov. Cond. lever contacts1.52.12.11.5
Pavlov. Cond. magazine entry number2.32.82.8-1.7
Pavlov. Cond. intertrial magazine entries0.20.30.3-0.6
Pavlov. Cond. lever-magazine prob. diff.2.93.83.82.0
Pavlov. Cond. response bias2.53.53.51.9
Time in closed arm before self-admin0.10.20.2-0.4
Time in closed arm after self-admin1.01.11.1-1.0
Time in open arm before self-admin0.00.00.00.1
Time in open arm after self-admin3.33.63.61.9
Bone: periosteal estimation7.014.814.8-3.8
Bone: periosteal perimeter3.45.95.9-2.4
Bone: post-yield work2.43.53.5-1.9
Progressive ratio test 1 active lever presses0.20.20.2-0.5
Progressive ratio test 1 breakpoint0.20.20.2-0.5
Progressive ratio test 1 inactive lever presses0.71.01.01.0
Progressive ratio test 2 active lever presses0.50.60.6-0.8
Progressive ratio test 2 breakpoint0.70.70.7-0.9
Progressive ratio test 2 inactive lever presses0.00.00.0-0.1
Incentive Sensitization - Responses0.10.20.2-0.4
Incentive Sensitization - Breakpoint0.20.20.2-0.5
Sum of active levers in priming session hrs 5-60.10.10.10.3
Progressive ratio0.30.50.50.7
Food seeking constrained by brief footshock1.01.21.21.1
Seeking ratio, punishment vs. effort0.00.10.1-0.2
Retroperitoneal fat weight7.029.929.95.5
Reaction time number correct0.00.00.00.0
Reaction time mean minus median0.00.00.0-0.2
Reaction time mean minus median AUC0.00.00.00.0
Reaction time num false alarms7.09.99.9-3.1
Reaction time num false alarms AUC6.29.79.7-3.1
Reaction time trials correct on left0.00.00.00.0
Reaction time trials on left0.00.00.0-0.0
Reaction time mean0.20.40.40.6
Reaction time mean AUC0.50.80.80.9
Median of all reaction times0.30.50.50.7
Reaction time omissions0.10.20.2-0.5
Reaction time false alarm rate4.25.75.7-2.4
Reaction time premature initiation rate0.10.10.10.4
Reaction time premature initiations0.10.20.20.5
Std. dev. reaction times0.10.20.20.4
Reaction time trials completed0.00.00.0-0.0
Reaction time trials AUC0.00.00.00.1
Run reversals in cocaine runway, females1.91.91.9-1.4
Run reversals in cocaine runway, males8.08.08.02.8
Latency to leave start box in cocaine runway5.96.76.7-2.6
Latency to leave start box in cocaine runway, F6.37.17.1-2.7
Latency to leave start box in cocaine runway, M1.11.01.0-1.0
Std. dev. time between licks in bursts4.46.06.0-2.4
Total sessions with >9 infusions0.00.00.00.1
Short access day 1 total inactive lever presses1.21.61.61.3
Short access day 10 total inactive lever presses1.33.23.21.8
Short access day 1 total infusions0.10.10.10.3
Short access day 10 total infusions0.00.00.0-0.1
Short access total infusions0.10.20.20.4
Short access day 1 locomotion0.00.00.00.1
Short access day 10 total locomotion0.50.90.9-1.0
Short access total locomotion1.11.31.3-1.1
One hour access (0.3 mA shock)0.00.00.0-0.1
Compulsive drug intake1.72.02.01.4
One hour access (shock baseline)0.91.31.3-1.1
Social response proportion0.60.60.60.8
Social responses1.11.41.4-1.2
Social time6.89.29.2-3.0
Soleus weight1.33.83.82.0
Bone: stiffness2.23.63.6-1.9
Tibialis anterior weight0.92.92.91.7
Time to tail flick, vehicle, before self-admin0.60.60.60.8
Time to tail flick, vehicle, after self-admin5.06.66.6-2.6
Time to tail flick, test, before self-admin1.11.21.2-1.1
Time to tail flick, test, after self-admin0.00.00.0-0.0
Delta time to tail flick, vehicle, before/after SA5.45.25.2-2.3
Delta time to tail flick, test, before/after SA0.10.10.10.3
Tibia length2.77.47.4-2.7
Ambulatory time before self-admin2.33.43.41.8
Ambulatory time after self-admin0.10.20.2-0.4
Bone: tissue strength0.20.20.20.4
Total heroin consumption0.91.11.11.0
Bone: trabecular number4.57.57.5-2.7
Bone: trabecular spacing2.83.73.71.9
Bone: trabecular thickness0.30.40.4-0.6
Bone: trabecular tissue density0.20.30.3-0.5
Water consumed over 24 hours0.50.70.70.9
Number of responses in last shaping day0.00.00.00.1