Zmat3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Zmat3	0.16	0.08	1.0e-08	0.14	0.14	0.12	0.15	9.7e-08	5.9e-08	9.5e-07	1.6e-08
2	LHb	gene expression	Zmat3	0.15	0.09	8.6e-04	0	-0.01	-0.01	-0.01	3.1e-01	4.8e-01	5.0e-01	8.7e-01
3	Brain	gene expression	Zmat3	0.06	0.04	5.9e-06	0.04	0.04	0.03	0.04	4.4e-05	9.7e-05	2.1e-03	3.0e-04
4	PL	gene expression	Zmat3	0.06	0.04	3.1e-06	0.05	0.05	0.06	0.05	3.7e-06	3.8e-06	1.1e-06	1.4e-06
5	Eye	gene expression	Zmat3	0.37	0.2	4.5e-03	0.14	0.16	0.15	0.18	4.3e-03	1.9e-03	2.9e-03	8.5e-04
6	Brain	mRNA stability	Zmat3	0.04	0.03	4.8e-03	0.02	0.02	0.02	0.02	6.5e-03	6.6e-03	5.4e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.8	3.0	6.2	-2.5	2.5	1.3	1.3	-1.4	0.4
Area under the delay curve	1.3	1.4	1.7	-1.3	1.3	1.2	1.2	-1.3	0.9
BMI with tail	0.9	2.9	3.8	-1.4	1.4	2.0	1.9	-1.9	1.6
BMI without tail	1.5	3.0	3.9	-1.6	1.5	1.7	1.8	-2.0	1.7
Body weight	0.3	1.4	3.2	0.1	-0.1	1.2	1.4	-1.3	1.8
Weight adjusted by age	3.6	4.0	5.9	1.3	-1.3	-2.1	-2.3	2.4	-2.3
Bone surface	0.1	0.1	0.2	-0.5	0.5	-0.1	-0.1	0.1	-0.4
Bone volume	0.2	0.3	0.6	-0.7	0.8	-0.3	-0.3	0.2	-0.6
Breakpoint value in progressive ratio session	2.1	2.3	3.1	-1.8	1.7	1.7	1.6	-1.5	0.8
Number of licking bursts	2.1	2.5	3.3	-1.1	1.1	1.7	1.7	-1.8	1.8
Context. condit. distance diff. score	2.1	2.6	6.6	-2.5	2.6	0.6	1.0	-1.0	-0.3
Locomotion velocity, session 1	1.2	1.2	3.1	1.3	-1.2	0.5	0.8	-0.8	1.8
Locomotion distance, session 1	1.0	1.3	3.3	0.7	-0.7	0.9	1.1	-1.1	1.8
Locomotion velocity, session 2	1.4	1.6	3.5	1.9	-1.9	0.1	0.2	-0.3	1.6
Locomotion distance, session 2	0.5	0.7	1.6	1.3	-1.3	0.2	0.2	-0.1	1.0
Locomotion velocity, session 3	0.1	0.1	0.4	0.0	-0.0	0.0	0.4	-0.4	0.6
Locomotion distance, session 3	0.2	0.2	0.5	0.6	-0.7	-0.2	-0.0	0.0	0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3	-0.3
Stereotopy head waving duration, day 3	0.5	0.6	1.2	-1.0	1.1	0.6	0.6	-0.6	0.3
Locomotion velocity, session 7	0.7	0.7	1.0	0.9	-1.0	-1.0	-0.8	0.9	-0.5
Locomotion distance, session 7	0.7	0.9	1.3	0.9	-0.9	-1.1	-1.0	1.0	-0.7
Stereotopy head waving bouts, day 7	2.5	2.8	3.8	-1.2	1.1	1.8	2.0	-2.0	1.9
Stereotopy head waving duration, day 7	2.3	2.8	3.7	-1.2	1.2	1.8	1.9	-1.9	1.7
Locomotion velocity, session 8	2.1	2.6	3.4	-1.5	1.5	1.7	1.8	-1.6	1.3
Locomotion distance, session 8	0.6	0.8	1.8	-1.2	1.3	0.5	0.8	-0.8	0.3
Degree of sensitization distance	1.7	1.7	2.5	0.8	-0.7	-1.6	-1.5	1.5	-1.5
Degree of sensitization stereotypy	2.8	3.1	4.0	-1.3	1.3	1.9	2.0	-2.0	1.8
Conditioned locomotion	0.5	0.6	1.5	-0.1	0.1	-0.9	-0.9	0.8	-1.2
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.1	0.3	-0.6	-0.5	0.4	-0.6
Cocaine response after cond. not corrected	0.3	0.4	0.6	0.5	-0.4	-0.8	-0.7	0.6	-0.6
Cocaine response before conditioning	0.1	0.1	0.2	0.3	-0.5	0.1	0.1	0.1	0.2
Saline control response	0.7	0.9	1.4	0.7	-0.7	-1.2	-1.0	1.0	-0.9
Bone: connectivity density	1.3	2.0	3.3	-1.8	1.8	1.3	1.3	-1.3	0.7
Bone: cortical apparent density	0.1	0.1	0.2	-0.3	0.3	-0.5	-0.3	0.2	-0.5
Bone: cortical area	0.9	1.3	3.0	-0.2	0.2	-1.2	-1.3	1.3	-1.7
Bone: cortical porosity	0.1	0.1	0.3	-0.2	0.2	-0.3	-0.4	0.4	-0.6
Bone: cortical porosity	0.2	0.2	0.6	-0.3	0.3	-0.4	-0.5	0.5	-0.8
Bone: cortical thickness	0.6	1.0	2.5	-0.6	0.6	-0.9	-0.9	1.0	-1.6
Bone: cortical thickness	0.4	0.5	1.4	0.5	-0.4	0.6	0.6	-0.7	1.2
Bone: cortical tissue density	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.2	0.2	-0.4
Condit. Reinf. active minus inactive responses	1.0	1.2	2.2	1.5	-1.5	-0.9	-1.0	0.9	-0.3
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.6	1.3	-1.2	-1.2	-1.2	1.2	-0.8
Condit. Reinf. active responses	0.5	0.6	1.4	1.1	-1.2	-0.4	-0.5	0.4	0.1
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.1	0.0	0.8	0.6	-0.8	0.9
Incentive salience index mean	0.9	1.1	2.6	1.6	-1.5	-0.7	-0.9	0.7	0.0
Condit. Reinf. lever presses	0.3	0.3	0.8	0.9	-0.8	0.1	-0.1	-0.1	0.7
Condit. Reinf. active minus inactive responses	1.0	1.3	1.7	1.3	-1.3	-1.3	-1.1	1.1	-0.6
Condit. Reinf. active-inactive response ratio	1.1	1.1	1.7	1.1	-1.0	-1.3	-1.1	1.0	-0.7
Condit. Reinf. active responses	1.7	2.4	4.6	2.1	-2.2	-1.4	-1.3	1.2	-0.3
Condit. Reinf. inactive responses	0.8	1.0	2.7	1.6	-1.6	-0.4	-0.4	0.4	0.4
Condit. Reinf. lever presses	0.2	0.2	0.4	0.5	-0.5	-0.6	-0.5	0.3	-0.0
Condit. Reinf. lever reinforcers received	1.6	2.2	4.3	2.0	-2.1	-1.4	-1.2	1.2	-0.2
Conditioned reinforcement - actives	0.5	0.5	0.7	0.6	-0.5	-0.8	-0.6	0.8	-0.8
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	-0.2	0.2
Conditioned locomotion	0.2	0.2	0.5	0.7	-0.7	0.0	0.1	0.5	-0.3
Patch foraging indifference point 0 sec	0.4	0.6	1.2	-1.0	0.7	1.1	0.6	-0.7	0.5
Patch foraging indifference point AUC	4.7	5.4	9.3	-1.0	0.9	2.4	2.8	-2.7	3.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.5	-0.5	-0.1	0.0	0.1	0.3
Delay disc. indifference point, 16s delay	0.9	0.9	2.2	-1.4	1.5	0.6	0.4	-0.4	-0.7
Delay disc. indifference point, 2s delay	0.7	0.8	1.2	-0.9	0.9	0.9	1.1	-0.8	0.6
Delay disc. indifference point, 24s delay	0.8	0.8	2.1	-1.4	1.4	0.4	-0.0	-0.2	-0.8
Delay disc. indifference point, 4s delay	0.8	0.8	1.6	-0.5	0.5	0.8	1.1	-1.1	1.3
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	-0.6	0.6	0.7	0.7	-0.9	0.9
Indifference point function ln k	3.4	4.7	7.2	1.2	-1.1	-2.3	-2.7	2.5	-2.6
Indifference point function log k	3.4	4.7	7.2	1.2	-1.1	-2.3	-2.7	2.5	-2.6
Patch foraging total patch changes 0 sec	0.5	0.8	1.5	-1.0	0.8	1.2	0.8	-0.8	0.6
Patch foraging total patch changes 12 sec	1.6	2.1	2.7	-1.1	0.9	1.6	1.6	-1.6	1.6
Patch foraging total patch changes 18 sec	1.8	2.3	3.5	-1.0	0.8	1.9	1.7	-1.6	1.8
Patch foraging total patch changes 24 sec	5.2	6.3	7.4	-2.5	2.4	2.7	2.7	-2.7	2.0
Patch foraging total patch changes 6 sec	3.2	4.7	6.7	-2.1	1.8	2.6	2.3	-2.2	1.8
Patch foraging time to switch 0 sec	0.3	0.5	0.9	0.1	0.0	-0.9	-0.8	0.7	-1.0
Patch foraging water rate 0 sec	0.3	0.4	1.0	-0.5	0.3	1.0	0.7	-0.6	0.6
Patch foraging water rate 12 sec	0.4	0.7	1.3	0.1	-0.2	-0.8	-1.0	1.0	-1.1
Patch foraging water rate 18 sec	0.2	0.2	0.7	0.7	-0.8	0.1	-0.3	0.1	0.4
Patch foraging water rate 24 sec	0.6	0.8	1.5	-1.1	0.9	1.2	0.8	-0.8	0.5
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.1	-0.3	0.3	-0.1	0.2	-0.0
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	2.0	-1.2	1.4	-1.0	-0.2	0.4	-1.4
Distance traveled before self-admin	1.3	1.4	2.0	-1.4	1.4	1.1	1.2	-1.1	0.5
Distance traveled after self-admin	0.3	0.4	1.0	-0.5	0.3	1.0	0.7	-0.4	0.5
Extensor digitorum longus weight	0.5	1.9	3.1	-0.3	0.3	1.7	1.7	-1.5	1.8
Bone: elastic displacement	0.8	0.9	1.9	-0.1	0.1	-1.1	-0.9	1.1	-1.4
Bone: elastic work	2.9	3.7	6.2	0.8	-0.7	-2.2	-2.2	2.3	-2.5
Bone: endosteal estimation	0.5	1.0	1.2	1.0	-1.1	-1.0	-1.0	1.1	-0.8
Bone: endosteal perimeter	0.3	0.7	1.4	1.2	-1.2	-0.6	-0.6	0.6	-0.2
Epididymis fat weight	0.3	0.6	1.8	1.3	-1.3	-0.3	-0.1	0.3	0.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.5	0.6	0.1	0.3	-0.5	0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.6	0.7	-0.8	-0.1	-0.3	0.5	0.0
Diff in mean of infusions in LGA sessions	0.3	0.3	0.9	-0.6	0.6	0.0	-0.1	0.3	-1.0
Delay discount exponential model param	1.6	1.6	2.0	1.4	-1.4	-1.2	-1.3	1.4	-1.0
Extinction: sum of active levers before priming	1.6	1.6	3.6	0.5	-0.7	-1.0	-1.1	1.7	-1.9
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.2	0.1	-0.5
Bone: final force	0.8	1.2	1.8	0.6	-0.6	-1.2	-1.4	1.3	-1.3
Bone: final moment	0.9	1.4	2.4	0.4	-0.4	-1.3	-1.4	1.4	-1.6
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	-0.1	0.1
Glucose	1.1	1.7	2.8	1.7	-1.6	-1.3	-1.3	1.1	-0.5
Heart weight	0.2	0.3	0.9	-0.9	0.9	0.1	0.3	-0.4	-0.3
Delay discount hyperbolic model param	1.3	1.3	1.6	1.2	-1.2	-1.1	-1.2	1.3	-1.0
Intermittent access intake day 1-15 change	0.9	0.9	1.3	-0.6	0.5	1.1	1.2	-1.0	1.0
Intermittent access intake escalation	1.1	1.0	1.8	-0.5	0.4	1.3	1.2	-1.1	1.2
Intermittent access intake escalation 2	0.1	0.1	0.4	0.5	-0.6	0.2	0.1	0.0	0.4
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	0.2	-0.2	-0.2	-0.6	0.5	-0.6
Intermitt. access day 15 inactive lever presses	0.3	0.4	1.1	1.0	-1.0	0.2	-0.1	0.2	0.3
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1	0.1	-0.0
Intermittent access day 1 total infusions	1.8	2.1	4.1	2.0	-1.9	-1.4	-1.1	1.2	-0.5
Intermittent access day 15 total infusions	0.4	0.4	0.9	0.7	-0.6	0.5	0.7	-0.4	0.9
Intermittent access terminal intake (last 3 days)	0.8	0.9	2.5	1.6	-1.5	-0.3	0.1	0.1	0.8
Intermittent access total infusions	0.6	0.7	2.1	1.5	-1.3	-0.2	-0.0	0.2	0.5
Intermittent access day 1 locomotion	0.4	0.4	0.8	0.9	-0.8	-0.7	-0.4	0.5	-0.2
Intermittent access day 15 total locomotion	0.9	1.0	1.3	-0.9	0.9	1.1	1.1	-1.0	0.8
Intermittent access total locomotion	0.5	0.6	1.3	0.3	-0.2	0.8	0.9	-0.8	1.2
Intermittent access standard deviation	0.1	0.1	0.3	-0.2	0.1	0.5	0.3	-0.2	0.1
Left kidney weight	0.1	0.3	0.5	-0.6	0.5	0.4	0.5	-0.7	0.5
Right kidney weight	0.6	1.7	2.7	-1.0	0.9	1.2	1.5	-1.6	1.5
Cocaine induced anxiety	0.3	0.3	0.8	0.8	-0.9	0.3	0.1	-0.1	0.7
Post-drug Anxiety	0.6	0.7	1.9	1.4	-1.4	-0.1	-0.4	0.4	0.5
Baseline Anxiety	0.1	0.1	0.2	-0.5	0.4	0.1	-0.2	0.1	-0.3
Tail length	0.0	0.0	0.1	0.0	-0.1	-0.2	-0.2	0.1	0.0
Length with tail	0.1	0.4	0.9	0.9	-0.9	-0.4	-0.4	0.3	0.1
Length without tail	0.9	2.0	2.4	1.5	-1.4	-1.5	-1.5	1.5	-1.2
Times rat made contact with spout	0.8	0.9	1.4	1.2	-1.1	-0.8	-0.9	1.0	-0.5
Lifetime Intake	0.9	1.0	2.9	1.7	-1.6	-0.5	-0.4	0.5	0.3
Liver weight, left	0.6	1.0	2.2	1.5	-1.3	0.1	0.4	-0.4	1.3
Liver weight, right	0.0	0.1	0.1	0.4	-0.4	-0.1	-0.1	0.3	-0.2
Locomotor activity	1.7	2.7	4.6	1.5	-1.3	-2.1	-1.7	1.6	-1.3
Locomotor testing distance	0.6	1.1	2.4	0.9	-0.7	-1.5	-1.0	0.9	-0.8
Locomotor testing rearing	0.5	0.8	1.5	0.2	-0.1	-1.2	-1.0	1.0	-1.2
Locomotion in novel chamber	0.5	0.6	1.9	0.6	-0.6	0.3	0.7	-0.7	1.4
Locomotion in novel chamber post-restriction	0.1	0.1	0.4	-0.5	0.6	0.2	0.3	-0.3	0.1
Fecal boli incidents, locomotor time 1	1.3	1.4	1.8	1.3	-1.3	-1.4	-1.3	1.1	-0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.7	0.7	0.7	0.5	-0.5	0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.6	0.2	-0.2
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.0	0.0	-0.8	-0.7	0.4	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.9	0.2	-0.1	-0.9	-0.8	0.5	-0.6
Rest time, locomotor task time 1	0.7	0.8	1.6	1.0	-1.0	-1.3	-0.9	0.6	-0.0
Distance moved, locomotor task time 1	2.5	2.7	4.7	-1.0	1.0	2.2	2.0	-1.7	1.7
Vertical activity count, locomotor time 1	2.3	2.4	4.4	-1.0	0.9	2.1	1.9	-1.5	1.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	0.6	-0.6	-0.3	-0.3	0.3	0.2
Bouts of movement, locomotor time 2	0.3	0.3	1.1	-0.4	0.3	-0.5	-0.4	0.5	-1.0
Total resting periods, locomotor time 2	0.3	0.3	0.9	-0.2	0.2	-0.6	-0.5	0.6	-1.0
Rest time, locomotor task time 2	0.3	0.4	1.4	-0.1	0.1	-1.2	-0.8	0.2	-0.5
Distance moved, locomotor task time 2	1.7	2.0	3.7	0.1	-0.0	1.8	1.8	-1.2	1.9
Vertical activity count, locomotor time 2	1.3	1.4	3.5	0.9	-0.9	1.2	1.0	-0.7	1.9
Light reinforcement 1	1.3	2.4	3.9	0.7	-0.7	-1.7	-2.0	1.8	-1.9
Light reinforcement 2	0.0	0.0	0.1	0.3	-0.2	0.2	-0.0	0.1	0.1
Bone: marrow area	0.3	0.7	0.9	0.9	-0.9	-0.8	-0.8	0.8	-0.6
Bone: maximum diameter	0.1	0.2	0.3	0.0	-0.1	-0.4	-0.5	0.4	-0.6
Bone: maximum force	1.4	2.4	3.5	0.9	-0.9	-1.6	-1.9	1.8	-1.9
Bone: maximum moment	1.6	2.8	4.6	0.7	-0.8	-1.7	-2.0	2.0	-2.1
Mean time between licks in bursts	1.4	1.9	2.8	1.0	-1.0	-1.6	-1.7	1.5	-1.4
Mean num. licks in bursts	2.4	2.8	4.0	1.5	-1.4	-1.7	-1.7	2.0	-1.8
Cd content in liver	0.9	0.9	2.4	1.5	-1.6	-0.4	-0.6	0.6	-0.0
Co content in liver	0.8	0.9	2.0	0.8	-0.8	0.8	0.9	-0.8	1.4
Cu content in liver	0.2	0.2	0.4	0.6	-0.5	-0.4	-0.5	0.5	-0.3
Fe content in liver	0.7	0.9	1.3	0.6	-0.6	-0.9	-1.1	1.1	-1.0
K content in liver	0.4	0.4	1.2	-1.1	1.0	-0.1	-0.1	-0.0	-0.5
Mg content in liver	0.6	0.6	1.4	-0.8	0.8	-0.7	-0.7	0.6	-1.2
Mn content in liver	1.2	1.4	2.8	-0.5	0.6	-1.4	-1.3	1.1	-1.7
Na content in liver	1.8	1.9	2.3	-1.4	1.5	1.2	1.5	-1.5	1.1
Rb content in liver	0.4	0.6	1.0	-1.0	1.0	-0.5	-0.4	0.3	-0.9
Se content in liver	0.4	0.5	1.3	1.1	-1.1	-0.5	-0.5	0.5	0.0
Sr content in liver	1.1	1.0	1.9	-0.1	0.0	1.2	1.2	-1.1	1.4
Zn content in liver	0.3	0.4	0.7	0.1	-0.3	-0.4	-0.8	0.8	-0.8
Bone: minimum diameter	1.9	3.5	5.0	1.0	-1.1	-2.1	-2.2	2.2	-2.2
Time in familiar zone, hab. session 1	0.6	0.6	1.3	0.2	-0.1	0.8	0.9	-0.9	1.1
Time in novel zone, hab. session 1	0.8	0.8	2.3	-1.5	1.4	0.1	-0.1	-0.1	-0.7
Total zone transitions, hab. session 1	0.9	1.3	2.0	-0.8	0.8	1.1	1.2	-1.4	1.4
Total locomotion distance, hab. session 1	1.8	2.5	4.0	-2.0	2.0	1.4	1.5	-1.5	0.8
Locomotion velocity, hab. session 1	1.5	2.1	3.5	-1.9	1.8	1.3	1.4	-1.4	0.8
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.2	0.2	-0.3
Time in novel zone, hab. session 2	0.5	0.5	1.3	-1.1	1.1	0.1	0.3	-0.4	-0.1
Total zone transitions, hab. session 2	0.2	0.2	0.6	0.2	-0.2	0.4	0.5	-0.5	0.8
Total locomotion distance, hab. session 2	0.3	0.3	0.6	-0.5	0.5	0.5	0.7	-0.7	0.6
Locomotion velocity, hab. session 2	0.2	0.2	0.4	-0.2	0.2	0.4	0.6	-0.7	0.6
Novel to familiar place preference ratio	4.8	4.9	9.7	-3.1	3.1	1.7	1.8	-1.8	0.5
Novelty place preference	6.0	6.1	12.3	-3.5	3.5	1.9	2.0	-2.0	0.6
Time in novel zone, NPP test	6.3	6.5	13.6	-3.7	3.7	1.9	2.0	-2.0	0.4
Total zone transitions, NPP test	0.6	0.9	1.7	1.3	-1.3	0.3	0.4	-0.3	1.2
Total locomotion distance, NPP test	0.3	0.4	0.8	0.7	-0.7	0.5	0.5	-0.4	0.9
Locomotion velocity, NPP test	0.3	0.5	0.9	1.0	-1.0	0.3	0.2	-0.3	0.9
Intraocular pressure	0.7	1.0	1.3	1.1	-0.9	-1.1	-1.0	1.0	-0.8
Delta distance traveled before/after self-admin	0.5	0.5	1.1	1.0	-1.0	-0.2	-0.6	0.8	-0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.5	0.7	-0.6	-0.0	-0.4	0.6	-0.2
Parametrial fat weight	0.2	0.3	0.9	0.3	-0.3	0.4	0.6	-0.6	0.9
Pavlov. Cond. lever latency	0.7	0.8	2.1	-1.5	1.4	-0.0	0.0	0.1	-1.0
Pavlov. Cond. magazine entry latency	0.5	0.7	1.2	-0.2	0.3	1.0	0.9	-0.9	1.1
Pavlov. Cond. change in total contacts	0.9	1.0	2.7	0.6	-0.6	0.9	0.9	-1.0	1.6
Pavlov. Cond. index score	1.6	2.1	5.3	0.7	-0.5	1.5	1.4	-1.5	2.3
Pavlov. Cond. latency score	1.1	1.5	3.9	1.1	-0.9	1.0	0.9	-1.0	2.0
Pavlov. Cond. lever contacts	0.7	0.9	1.8	1.4	-1.2	0.2	0.2	-0.3	1.2
Pavlov. Cond. magazine entry number	2.7	3.4	6.3	0.3	-0.4	-2.3	-2.1	2.0	-2.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.0	0.6	-0.8	-1.0	-0.9	1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	5.1	0.5	-0.3	1.5	1.4	-1.5	2.3
Pavlov. Cond. response bias	2.0	2.4	4.8	-0.1	0.3	1.9	1.8	-1.7	2.2
Pavlov. Cond. lever latency	0.3	0.5	1.1	0.2	-0.1	-0.7	-0.8	0.8	-1.0
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.0	-0.2	0.8	0.8	-0.5	0.8
Pavlov. Cond. change in total contacts	0.3	0.4	1.0	1.0	-1.0	-0.0	0.1	-0.1	0.8
Pavlov. Cond. index score	0.6	0.8	1.7	0.0	-0.1	1.0	1.0	-0.9	1.3
Pavlov. Cond. latency score	0.6	0.8	1.8	0.2	-0.2	1.0	1.0	-0.9	1.3
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.5	0.4	0.7	0.7	-0.6	0.7
Pavlov. Cond. magazine entry number	1.1	1.3	2.0	0.4	-0.4	-1.4	-1.4	1.2	-1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.3	-0.3	-0.5	-0.5	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.0	0.2	-0.2	1.0	1.1	-0.9	1.4
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.4	0.3	0.7	0.7	-0.6	0.7
Time in closed arm before self-admin	0.1	0.1	0.4	-0.4	0.4	0.1	0.1	0.3	-0.6
Time in closed arm after self-admin	0.1	0.1	0.4	-0.3	0.3	-0.1	-0.2	0.3	-0.6
Time in open arm before self-admin	1.1	1.2	1.8	-1.1	1.4	0.9	1.1	-1.3	0.8
Time in open arm after self-admin	0.2	0.2	0.4	-0.2	0.2	0.3	0.4	-0.5	0.7
Bone: periosteal estimation	0.7	1.4	2.2	0.6	-0.6	-1.3	-1.3	1.4	-1.5
Bone: periosteal perimeter	0.6	1.0	1.5	0.5	-0.5	-1.1	-1.2	1.2	-1.2
Bone: post-yield work	1.0	1.4	3.6	1.8	-1.9	-0.5	-0.7	0.8	0.0
Progressive ratio test 1 active lever presses	0.8	0.8	1.6	1.3	-1.2	-0.9	-0.7	0.7	-0.3
Progressive ratio test 1 breakpoint	0.9	0.9	1.8	1.3	-1.2	-0.9	-0.7	0.8	-0.4
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.1	1.1	-1.0	-0.4	-0.6	0.7	-0.4
Progressive ratio test 2 active lever presses	0.5	0.6	1.4	0.8	-0.7	0.5	0.7	-0.6	1.2
Progressive ratio test 2 breakpoint	0.6	0.6	1.6	0.6	-0.4	0.7	0.8	-0.7	1.2
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.9	0.9	-0.9	0.4	0.3	-0.0	0.5
Incentive Sensitization - Responses	1.4	1.4	3.0	-0.1	0.2	1.3	1.4	-1.4	1.7
Incentive Sensitization - Breakpoint	1.3	1.3	3.1	0.1	0.0	1.2	1.3	-1.3	1.8
Sum of active levers in priming session hrs 5-6	1.7	1.6	2.5	1.6	-1.5	-1.2	-1.3	1.2	-0.6
Progressive ratio	0.2	0.2	0.3	0.3	-0.3	-0.5	-0.6	0.5	-0.6
Food seeking constrained by brief footshock	0.2	0.2	0.7	-0.7	0.9	-0.3	-0.1	-0.2	-0.2
Seeking ratio, punishment vs. effort	0.5	0.7	1.0	-0.9	1.0	0.6	0.7	-0.9	0.7
Retroperitoneal fat weight	0.1	0.3	0.6	0.8	-0.7	-0.5	-0.4	0.4	-0.1
Reaction time number correct	1.3	1.9	5.1	2.3	-2.2	-0.6	-0.5	0.8	0.4
Reaction time mean minus median	0.1	0.1	0.3	0.0	0.1	0.2	0.3	-0.3	0.5
Reaction time mean minus median AUC	0.4	0.5	0.6	-0.5	0.5	0.7	0.8	-0.8	0.8
Reaction time num false alarms	0.0	0.0	0.1	-0.2	0.3	0.1	0.1	0.0	-0.1
Reaction time num false alarms AUC	0.0	0.0	0.0	-0.0	0.0	0.1	0.2	-0.0	0.0
Reaction time trials correct on left	1.3	1.9	5.1	2.3	-2.2	-0.6	-0.5	0.8	0.4
Reaction time trials on left	1.4	2.0	5.3	2.3	-2.2	-0.7	-0.5	0.8	0.3
Reaction time mean	1.1	1.5	2.2	1.5	-1.5	-1.2	-1.2	1.2	-0.6
Reaction time mean AUC	1.0	1.3	1.6	1.3	-1.2	-1.1	-1.1	1.2	-0.7
Median of all reaction times	1.2	1.6	2.2	1.5	-1.5	-1.3	-1.2	1.3	-0.7
Reaction time omissions	1.3	1.7	2.6	0.9	-1.0	-1.3	-1.3	1.6	-1.6
Reaction time false alarm rate	0.5	0.7	1.6	-1.3	1.3	0.4	0.5	-0.5	-0.1
Reaction time premature initiation rate	0.3	0.4	1.0	-1.0	0.9	0.5	0.3	-0.3	-0.1
Reaction time premature initiations	0.1	0.1	0.2	0.4	-0.4	0.1	-0.1	0.3	-0.0
Std. dev. reaction times	0.0	0.0	0.1	0.4	-0.3	-0.1	0.0	-0.0	0.3
Reaction time trials completed	1.4	2.0	5.3	2.3	-2.2	-0.7	-0.5	0.8	0.3
Reaction time trials AUC	1.4	2.0	5.2	2.3	-2.2	-0.7	-0.6	0.9	0.2
Run reversals in cocaine runway, females	0.2	0.1	0.3	-0.1	0.2	0.6	0.3	-0.4	0.5
Run reversals in cocaine runway, males	0.1	0.1	0.4	0.6	-0.6	0.1	0.1	0.1	0.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.3	-0.3	-0.1	-0.3	0.1	-0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.4	-0.3	-0.1	-0.4	0.1	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.2	0.2	-0.4
Std. dev. time between licks in bursts	0.4	0.4	1.0	0.9	-1.0	-0.4	-0.7	0.2	0.3
Total sessions with >9 infusions	2.1	2.3	3.0	1.2	-1.1	-1.6	-1.6	1.7	-1.7
Short access day 1 total inactive lever presses	1.3	1.5	2.3	-0.9	0.9	1.5	1.3	-1.4	1.1
Short access day 10 total inactive lever presses	1.3	1.4	2.3	-1.2	1.1	1.5	1.2	-1.2	0.8
Short access day 1 total infusions	0.5	0.5	1.0	1.0	-1.0	-0.6	-0.5	0.5	-0.1
Short access day 10 total infusions	0.8	0.9	1.8	1.4	-1.3	-0.8	-0.7	0.8	-0.3
Short access total infusions	1.1	1.2	2.6	1.6	-1.5	-1.0	-0.9	0.9	-0.3
Short access day 1 locomotion	0.6	0.6	0.9	-0.7	0.7	0.8	0.9	-0.9	0.7
Short access day 10 total locomotion	0.8	0.9	1.1	-0.7	0.7	1.0	1.0	-1.1	1.0
Short access total locomotion	0.1	0.1	0.3	0.5	-0.4	-0.3	-0.3	0.2	-0.1
One hour access (0.3 mA shock)	0.4	0.5	1.0	1.0	-1.0	0.1	0.2	-0.2	0.8
Compulsive drug intake	0.5	0.5	0.7	0.7	-0.9	-0.4	-0.8	0.7	-0.4
One hour access (shock baseline)	0.4	0.5	1.3	1.2	-1.1	0.0	0.2	-0.1	0.7
Social response proportion	2.7	3.0	4.6	1.7	-1.6	-1.8	-2.2	1.7	-1.3
Social responses	0.0	0.0	0.1	-0.3	0.2	0.0	-0.2	-0.2	0.1
Social time	3.5	4.6	7.2	1.6	-1.4	-2.7	-2.5	2.3	-2.2
Soleus weight	5.8	17.1	33.3	-5.8	5.7	3.4	3.4	-3.4	1.2
Bone: stiffness	0.6	1.0	1.5	0.5	-0.6	-1.0	-1.2	1.2	-1.2
Tibialis anterior weight	0.5	1.9	3.1	-0.8	0.8	1.8	1.6	-1.5	1.4
Time to tail flick, vehicle, before self-admin	1.9	1.9	2.9	1.1	-1.1	-1.4	-1.3	1.6	-1.7
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.4	1.6	-1.6	-0.9	-0.9	0.9	-0.3
Time to tail flick, test, before self-admin	0.8	0.8	2.2	-1.5	1.4	-0.0	0.1	-0.4	-0.6
Time to tail flick, test, after self-admin	1.9	1.9	3.7	-1.9	1.9	1.2	1.1	-1.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.0	1.0	-1.0	-0.2	-0.2	0.0	0.7
Delta time to tail flick, test, before/after SA	2.3	2.0	2.8	-1.2	1.2	1.7	1.7	-1.5	1.3
Tibia length	2.6	7.2	10.8	3.3	-3.3	-2.5	-2.5	2.6	-1.5
Ambulatory time before self-admin	0.6	0.7	1.4	-1.2	1.1	0.6	0.8	-0.6	-0.0
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	0.3	0.5	0.2	-0.1	-0.1
Bone: tissue strength	4.4	4.3	8.7	0.2	-0.2	-2.4	-2.4	2.4	-2.9
Total heroin consumption	3.4	3.9	7.0	-2.6	2.7	1.9	1.7	-1.7	0.4
Bone: trabecular number	5.2	8.1	10.9	-3.3	3.3	2.8	2.7	-2.8	1.8
Bone: trabecular spacing	4.1	5.4	6.2	2.5	-2.5	-2.4	-2.3	2.4	-1.7
Bone: trabecular thickness	0.2	0.3	0.8	-0.9	0.9	-0.0	0.1	-0.2	-0.2
Bone: trabecular tissue density	0.4	0.6	0.7	0.9	-0.9	-0.7	-0.7	0.7	-0.5
Water consumed over 24 hours	0.1	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3	-0.3
Number of responses in last shaping day	0.7	0.7	1.2	-0.6	0.6	1.1	1.0	-0.9	0.8