Hub : Genes

Zfp523

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Zfp523	0.04	0.02	1.2e-05	0.04	0.05	0.04	0.03	2.1e-05	7.4e-06	3.5e-05	2.3e-04
2	Eye	intron excision ratio	chr20_6261412_6262086	0.5	0.2	7.2e-03	-0.01	0	0	0.01	5.3e-01	3.0e-01	3.3e-01	1.9e-01
3	Liver	gene expression	Zfp523	0.04	0.03	1.4e-05	0.04	0.04	0.04	0.04	5.7e-05	3.0e-05	6.3e-05	3.8e-05
4	IC	intron excision ratio	chr20_6257951_6259934	0.12	0.07	6.7e-03	0.01	0.02	0	0.01	1.2e-01	3.6e-02	2.6e-01	1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.1	0.0	-0.3	0.0	0.4
Area under the delay curve	0.4	0.5	1.2	-0.1	0.5	-0.6	1.1
BMI with tail	2.0	6.9	10.9	-3.3	3.1	-2.6	0.7
BMI without tail	1.3	3.8	6.0	-2.3	2.4	-2.0	0.4
Body weight	2.3	9.9	15.7	-2.6	4.0	-3.8	1.6
Weight adjusted by age	0.7	1.0	2.8	0.1	0.6	-0.9	1.7
Bone surface	0.1	0.1	0.3	0.5	-0.3	0.1	-0.2
Bone volume	0.0	0.0	0.1	-0.0	0.2	-0.3	0.3
Breakpoint value in progressive ratio session	0.5	0.6	1.1	-1.0	0.4	-0.6	-0.8
Number of licking bursts	0.9	1.5	1.8	1.1	-1.1	1.3	-1.4
Context. condit. distance diff. score	1.7	2.1	3.4	1.8	-1.5	1.4	-0.9
Locomotion velocity, session 1	1.9	2.0	3.9	2.0	-1.4	1.4	0.4
Locomotion distance, session 1	2.2	2.8	4.3	1.7	-1.9	2.1	-0.5
Locomotion velocity, session 2	1.0	1.2	1.3	1.1	-1.0	1.1	-1.1
Locomotion distance, session 2	0.7	1.0	1.4	1.2	-1.1	1.1	-0.0
Locomotion velocity, session 3	0.3	0.3	0.6	0.5	0.1	0.8	-0.7
Locomotion distance, session 3	1.0	1.1	2.2	1.1	-0.8	1.5	-0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	0.1	0.5	-0.4	-0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.6	-0.2	0.0	0.1
Locomotion velocity, session 7	0.5	0.6	1.4	0.8	-0.3	0.3	1.2
Locomotion distance, session 7	1.1	1.4	2.3	1.5	-1.1	1.0	1.1
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	0.1	0.3	0.2	-0.2
Stereotopy head waving duration, day 7	0.1	0.2	0.4	-0.3	0.6	-0.1	-0.3
Locomotion velocity, session 8	1.4	1.7	3.8	1.9	-1.2	1.1	-0.7
Locomotion distance, session 8	2.1	3.1	4.6	2.2	-1.8	1.9	-1.0
Degree of sensitization distance	0.3	0.3	0.7	-0.0	0.1	-0.9	0.7
Degree of sensitization stereotypy	0.2	0.2	0.6	0.3	-0.3	0.8	-0.4
Conditioned locomotion	1.5	1.7	2.6	-1.4	1.6	-1.6	-0.1
Cocaine response after cond. corrected	0.5	0.6	0.9	-1.0	0.9	-0.6	-0.6
Cocaine response after cond. not corrected	0.2	0.3	0.7	-0.3	0.5	-0.3	-0.8
Cocaine response before conditioning	0.5	0.6	1.5	1.2	-0.8	0.6	-0.0
Saline control response	2.4	3.2	5.0	-2.2	1.7	-2.0	0.8
Bone: connectivity density	0.1	0.1	0.2	0.1	-0.3	-0.1	0.5
Bone: cortical apparent density	0.4	0.6	1.5	-1.2	0.8	-0.5	-0.3
Bone: cortical area	0.0	0.0	0.0	0.2	0.0	0.1	0.2
Bone: cortical porosity	0.7	0.8	1.2	1.1	-0.6	0.6	1.1
Bone: cortical porosity	1.2	1.3	2.8	1.3	-0.7	0.4	1.7
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.0	0.4	0.2
Bone: cortical thickness	1.0	1.2	2.9	-1.7	1.1	-0.9	0.2
Bone: cortical tissue density	0.4	0.6	1.3	-1.1	0.8	-0.5	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.5	1.6	0.6	-0.4	0.1	1.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.8	0.5	-0.7	0.5
Condit. Reinf. active responses	0.5	0.6	2.0	0.0	0.2	-0.5	1.4
Condit. Reinf. inactive responses	0.2	0.2	0.8	-0.1	0.2	-0.2	0.9
Incentive salience index mean	0.5	0.6	1.0	1.0	-0.6	0.4	0.8
Condit. Reinf. lever presses	0.3	0.5	1.2	1.1	-0.6	0.5	0.2
Condit. Reinf. active minus inactive responses	0.4	0.6	1.1	1.0	-0.9	0.6	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.7	-0.6	0.3	0.1
Condit. Reinf. active responses	0.4	0.6	1.0	1.0	-0.9	0.7	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.0
Condit. Reinf. lever presses	1.6	2.2	4.0	1.6	-2.0	1.4	0.5
Condit. Reinf. lever reinforcers received	0.8	1.2	1.8	1.4	-1.3	1.0	0.2
Conditioned reinforcement - actives	0.2	0.3	1.2	0.1	0.2	-0.3	1.1
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.5	-0.4	0.4	0.5
Conditioned locomotion	1.2	1.6	4.2	-0.1	1.0	-1.1	2.0
Patch foraging indifference point 0 sec	0.6	1.1	2.2	-1.5	1.0	-1.0	0.5
Patch foraging indifference point AUC	0.9	1.4	1.8	1.4	-1.1	1.2	-1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	-0.0	-0.0	0.4
Delay disc. indifference point, 16s delay	0.3	0.3	1.1	0.1	0.2	-0.2	1.1
Delay disc. indifference point, 2s delay	0.3	0.4	0.8	0.6	-0.5	0.0	0.9
Delay disc. indifference point, 24s delay	1.6	1.8	4.3	-0.4	1.2	-1.1	2.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	-0.4	0.7	-0.7	0.2
Delay disc. indifference point, 8s delay	0.8	0.9	1.8	-0.4	0.9	-1.0	1.3
Indifference point function ln k	0.2	0.4	0.6	0.7	-0.8	0.7	-0.2
Indifference point function log k	0.2	0.4	0.6	0.7	-0.8	0.7	-0.2
Patch foraging total patch changes 0 sec	0.6	1.1	2.1	-1.5	1.0	-1.0	0.5
Patch foraging total patch changes 12 sec	0.1	0.2	0.5	-0.2	-0.2	0.4	-0.7
Patch foraging total patch changes 18 sec	0.8	1.3	2.8	-1.7	1.2	-0.9	-0.3
Patch foraging total patch changes 24 sec	0.1	0.2	0.6	-0.8	0.1	-0.1	0.3
Patch foraging total patch changes 6 sec	0.4	0.6	1.4	-1.2	0.8	-0.6	0.3
Patch foraging time to switch 0 sec	1.9	3.9	6.7	-2.6	2.1	-2.0	0.4
Patch foraging water rate 0 sec	0.2	0.3	0.5	0.7	-0.7	0.5	0.3
Patch foraging water rate 12 sec	0.1	0.3	0.7	0.3	-0.5	0.9	-0.4
Patch foraging water rate 18 sec	0.2	0.3	0.7	-0.4	0.1	-0.5	0.9
Patch foraging water rate 24 sec	0.4	0.6	1.0	0.3	-0.7	1.0	-1.0
Patch foraging water rate 6 sec	0.3	0.4	0.7	0.5	-0.6	0.9	-0.7
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	3.0	-0.4	0.0	0.2	-1.7
Distance traveled before self-admin	0.5	0.7	2.1	-0.5	0.5	-0.2	-1.5
Distance traveled after self-admin	0.6	0.8	2.2	-0.7	0.4	-0.4	-1.5
Extensor digitorum longus weight	0.4	1.7	2.7	1.6	-1.6	1.1	-0.6
Bone: elastic displacement	0.5	0.6	1.8	0.6	-0.3	0.3	1.3
Bone: elastic work	0.4	0.6	2.0	-0.1	0.2	-0.4	1.4
Bone: endosteal estimation	0.7	1.5	3.5	-0.6	1.5	-1.9	0.1
Bone: endosteal perimeter	0.3	0.6	1.0	-0.2	0.9	-1.0	-0.6
Epididymis fat weight	3.8	12.9	27.1	-5.2	3.9	-2.9	0.9
Delta time in closed arm before/after self-admin	1.5	1.4	1.9	-1.1	1.4	-1.2	1.1
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.4	-0.6	0.4	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.4	-0.1	0.0	-0.5
Delay discount exponential model param	0.4	0.4	1.2	0.1	-0.4	0.6	-1.1
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.1	-0.3	0.4	-0.5
Active lever presses in extinction session 6	1.5	1.5	4.0	-0.7	0.7	-1.0	2.0
Bone: final force	3.2	5.1	7.3	-2.6	2.7	-2.4	0.6
Bone: final moment	2.4	3.9	5.4	-2.2	2.3	-2.2	0.8
Food consumed during 24 hour testing period	1.3	1.8	2.8	-1.6	1.3	-1.7	-0.1
Glucose	1.4	2.2	5.2	2.3	-1.5	1.1	0.6
Heart weight	1.5	2.4	2.9	1.7	-1.6	1.0	1.7
Delay discount hyperbolic model param	0.2	0.3	0.9	-0.2	-0.2	0.3	-0.9
Intermittent access intake day 1-15 change	0.5	1.0	1.4	-1.2	1.1	-0.9	-0.7
Intermittent access intake escalation	0.7	1.4	2.1	-1.4	1.4	-1.2	-0.4
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.1	0.3	-0.5	0.1
Intermitt. access day 1 inactive lever presses	1.0	3.7	6.5	1.0	-1.9	1.9	-2.6
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.4	-0.2	0.1	-0.2	-0.7
Intermitt. access escalation Index	1.3	1.8	4.4	0.4	-1.1	1.2	-2.1
Intermittent access day 1 total infusions	1.3	2.1	4.6	1.4	-1.1	0.7	2.1
Intermittent access day 15 total infusions	0.2	0.3	1.0	0.0	0.1	-0.2	1.0
Intermittent access terminal intake (last 3 days)	0.3	0.4	1.4	0.2	0.1	-0.1	1.2
Intermittent access total infusions	0.6	0.7	2.2	0.7	-0.4	0.2	1.5
Intermittent access day 1 locomotion	0.1	0.1	0.5	0.3	-0.0	-0.0	0.7
Intermittent access day 15 total locomotion	1.6	2.9	4.6	-1.4	2.1	-2.0	1.1
Intermittent access total locomotion	0.6	0.8	1.3	-0.3	0.8	-1.0	1.1
Intermittent access standard deviation	0.9	1.8	2.9	-1.7	1.5	-1.4	-0.2
Left kidney weight	1.1	4.9	8.2	-2.0	2.9	-2.6	0.6
Right kidney weight	1.8	8.3	14.3	-2.6	3.8	-3.4	0.7
Cocaine induced anxiety	0.5	0.8	2.1	0.5	-0.6	0.6	-1.4
Post-drug Anxiety	0.2	0.2	0.8	-0.1	-0.0	0.0	-0.9
Baseline Anxiety	0.9	1.0	1.6	-1.3	1.1	-0.9	0.7
Tail length	0.1	0.4	1.3	1.1	0.4	-0.4	-0.1
Length with tail	0.3	1.4	2.7	0.6	1.2	-1.6	1.0
Length without tail	1.3	4.0	7.0	-1.0	2.2	-2.6	1.8
Times rat made contact with spout	0.2	0.2	0.6	0.0	-0.8	0.6	0.3
Lifetime Intake	0.6	0.7	2.5	0.4	-0.1	-0.2	1.6
Liver weight, left	0.4	0.6	1.1	-0.4	0.9	-1.1	-0.5
Liver weight, right	0.3	0.5	1.2	0.8	0.5	-0.3	-1.1
Locomotor activity	0.5	0.8	2.9	0.1	-0.2	0.5	-1.7
Locomotor testing distance	0.4	0.7	2.4	-0.7	0.1	0.2	-1.6
Locomotor testing rearing	0.6	1.2	1.5	-1.2	1.1	-0.8	-1.2
Locomotion in novel chamber	0.2	0.2	0.6	0.4	-0.7	0.5	0.1
Locomotion in novel chamber post-restriction	1.4	2.3	3.2	-1.7	1.8	-1.7	0.6
Fecal boli incidents, locomotor time 1	0.5	0.7	1.4	-0.6	0.5	-1.0	1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.4	0.5	-0.2	-0.6
Time >=10cm from walls, locomotor time 1	2.7	2.8	4.3	-2.1	1.7	-1.7	-1.1
Bouts of movement, locomotor time 1	0.5	0.6	1.8	0.2	-0.6	0.5	-1.3
Total resting periods, locomotor time 1	0.3	0.3	1.1	0.2	-0.4	0.3	-1.0
Rest time, locomotor task time 1	0.4	0.5	1.3	1.1	-0.4	0.6	0.3
Distance moved, locomotor task time 1	0.5	0.7	1.3	-1.1	0.9	-0.8	-0.1
Vertical activity count, locomotor time 1	1.2	2.9	5.1	-2.3	1.6	-1.9	-0.1
Time >=10cm from walls, locomotor time 2	3.6	5.4	7.5	-2.2	2.7	-2.7	1.4
Bouts of movement, locomotor time 2	0.3	0.5	2.1	0.3	-0.1	0.2	-1.4
Total resting periods, locomotor time 2	0.6	1.1	2.6	0.8	-0.6	0.7	-1.6
Rest time, locomotor task time 2	0.9	1.1	2.4	0.8	-0.8	0.9	-1.5
Distance moved, locomotor task time 2	4.4	5.3	6.1	-2.0	2.4	-2.5	2.2
Vertical activity count, locomotor time 2	2.9	4.1	5.2	-1.7	2.0	-2.3	2.0
Light reinforcement 1	1.3	3.3	4.9	-2.2	2.0	-1.5	-1.4
Light reinforcement 2	1.6	2.4	3.6	-1.7	1.9	-1.7	-0.5
Bone: marrow area	0.8	1.8	4.0	-0.7	1.6	-2.0	0.2
Bone: maximum diameter	0.3	0.5	1.6	1.3	-0.5	0.4	-0.3
Bone: maximum force	0.7	1.3	1.8	-1.1	1.4	-1.3	0.7
Bone: maximum moment	0.5	0.9	1.1	-0.7	1.0	-1.1	1.0
Mean time between licks in bursts	2.1	5.3	7.9	2.8	-2.3	2.2	-1.7
Mean num. licks in bursts	0.4	0.6	1.6	-0.7	0.3	-0.6	1.2
Cd content in liver	1.7	1.9	3.3	-1.1	0.9	-1.5	1.8
Co content in liver	4.2	4.8	6.0	-2.4	2.4	-2.4	1.5
Cu content in liver	0.2	0.3	0.6	-0.1	-0.7	0.8	-0.2
Fe content in liver	0.7	0.9	1.7	-0.9	1.3	-1.0	0.2
K content in liver	1.6	1.5	2.4	1.6	-1.3	1.3	-0.2
Mg content in liver	2.5	2.6	3.6	1.9	-1.8	1.6	-1.1
Mn content in liver	2.0	2.2	3.9	2.0	-1.4	1.2	-1.2
Na content in liver	0.4	0.5	1.0	0.3	-0.4	0.8	-1.0
Rb content in liver	0.3	0.3	0.6	-0.3	0.3	-0.7	0.8
Se content in liver	4.6	5.4	9.1	3.0	-2.5	2.3	-1.0
Sr content in liver	0.9	0.7	2.2	-0.3	0.4	-0.8	1.5
Zn content in liver	1.1	1.2	2.1	1.5	-1.3	0.9	0.2
Bone: minimum diameter	0.1	0.3	0.6	-0.1	0.6	-0.8	0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.1	0.1	0.0	0.8
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.1	0.1	-0.0	-0.4
Total zone transitions, hab. session 1	2.1	3.0	5.1	1.5	-1.8	2.3	-1.1
Total locomotion distance, hab. session 1	2.3	3.3	5.1	1.8	-1.8	2.3	-1.2
Locomotion velocity, hab. session 1	2.2	3.2	4.9	1.8	-1.8	2.2	-1.1
Time in familiar zone, hab. session 2	1.5	1.6	4.7	0.1	-0.9	1.0	-2.2
Time in novel zone, hab. session 2	2.6	2.6	6.5	-0.5	1.2	-1.5	2.5
Total zone transitions, hab. session 2	1.3	1.6	3.6	0.6	-0.8	1.4	-1.9
Total locomotion distance, hab. session 2	3.1	4.0	6.0	1.3	-1.7	2.3	-2.4
Locomotion velocity, hab. session 2	3.8	5.1	7.2	1.6	-2.1	2.7	-2.5
Novel to familiar place preference ratio	0.3	0.3	1.0	-0.2	0.4	-0.3	1.0
Novelty place preference	0.2	0.2	0.8	-0.0	0.3	-0.2	0.9
Time in novel zone, NPP test	0.3	0.3	0.9	-0.1	0.4	-0.3	0.9
Total zone transitions, NPP test	1.8	2.6	4.0	1.7	-1.7	2.0	-0.9
Total locomotion distance, NPP test	0.6	0.8	1.3	0.9	-1.0	1.1	-0.0
Locomotion velocity, NPP test	0.9	1.3	2.3	1.0	-1.3	1.5	-0.5
Intraocular pressure	0.3	0.4	0.7	-0.5	0.8	-0.7	0.4
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.2	-0.1	-0.4	0.7
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.2	-0.1	-0.4	0.3
Parametrial fat weight	2.9	6.8	10.3	-3.2	3.1	-2.7	-0.7
Pavlov. Cond. lever latency	3.3	4.2	8.4	-2.9	2.0	-2.1	-0.5
Pavlov. Cond. magazine entry latency	2.8	3.6	7.1	2.7	-1.9	1.9	-0.2
Pavlov. Cond. change in total contacts	0.5	0.5	1.3	1.2	-0.2	0.5	0.6
Pavlov. Cond. index score	3.1	3.9	8.2	2.9	-1.9	1.9	0.4
Pavlov. Cond. latency score	2.9	3.6	7.7	2.8	-1.8	1.9	0.3
Pavlov. Cond. lever contacts	2.1	2.5	5.4	2.3	-1.4	1.5	0.7
Pavlov. Cond. magazine entry number	2.8	3.6	6.2	-2.5	2.0	-2.0	0.3
Pavlov. Cond. intertrial magazine entries	1.6	1.9	3.0	-1.2	1.2	-1.3	1.7
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.8	8.0	2.8	-1.8	1.9	0.5
Pavlov. Cond. response bias	3.7	4.6	8.8	3.0	-2.2	2.2	-0.0
Pavlov. Cond. lever latency	0.9	1.2	1.8	-1.1	1.3	-1.0	-0.9
Pavlov. Cond. magazine entry latency	0.4	0.4	1.0	0.0	0.4	-0.8	1.0
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	0.6	-0.8	0.4	0.7
Pavlov. Cond. index score	0.4	0.5	1.1	0.8	-0.6	0.2	1.1
Pavlov. Cond. latency score	0.3	0.4	0.8	0.6	-0.5	0.2	0.9
Pavlov. Cond. lever contacts	0.6	0.9	1.2	0.9	-1.1	0.7	1.0
Pavlov. Cond. magazine entry number	0.4	0.4	0.8	0.4	-0.4	0.8	-0.9
Pavlov. Cond. intertrial magazine entries	1.9	2.9	6.2	1.2	-1.3	1.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	0.6	-0.5	0.1	1.0
Pavlov. Cond. response bias	0.7	1.0	1.6	1.1	-0.9	0.5	1.3
Time in closed arm before self-admin	0.0	0.1	0.1	0.2	-0.3	0.1	0.3
Time in closed arm after self-admin	0.5	0.6	2.2	0.0	0.2	-0.2	1.5
Time in open arm before self-admin	0.4	0.4	0.7	0.8	-0.6	0.7	0.1
Time in open arm after self-admin	0.6	0.7	1.0	0.9	-1.0	0.7	-0.6
Bone: periosteal estimation	0.3	0.5	1.2	-0.3	0.9	-1.1	0.0
Bone: periosteal perimeter	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.3
Bone: post-yield work	0.2	0.3	0.6	0.3	0.2	-0.7	0.8
Progressive ratio test 1 active lever presses	0.4	0.5	1.9	0.1	0.1	-0.3	1.4
Progressive ratio test 1 breakpoint	0.4	0.5	1.8	0.2	-0.1	-0.1	1.3
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.2	-1.1	0.9	-0.7	0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.2	0.1	0.1	0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	0.2	0.0	0.1	0.7
Progressive ratio test 2 inactive lever presses	0.2	0.4	0.8	0.9	-0.4	0.4	0.7
Incentive Sensitization - Responses	0.7	1.0	1.4	0.8	-1.1	1.2	-0.8
Incentive Sensitization - Breakpoint	0.5	0.7	0.9	0.6	-0.9	1.0	-0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.4	-0.4	0.2	0.4
Progressive ratio	2.2	3.4	5.0	-2.2	2.2	-1.9	-0.5
Food seeking constrained by brief footshock	0.7	0.8	2.4	-0.5	0.4	-0.7	1.5
Seeking ratio, punishment vs. effort	1.5	2.1	2.9	1.7	-1.7	1.4	0.9
Retroperitoneal fat weight	0.4	1.7	3.2	-1.3	1.8	-1.3	-0.0
Reaction time number correct	0.9	1.8	3.3	-1.8	1.5	-1.2	-0.1
Reaction time mean minus median	0.2	0.6	1.9	1.4	-0.6	0.3	-0.2
Reaction time mean minus median AUC	0.3	0.7	1.5	1.2	-0.4	-0.1	1.0
Reaction time num false alarms	1.1	1.6	2.5	1.0	-1.2	1.2	-1.6
Reaction time num false alarms AUC	1.7	2.7	3.0	1.5	-1.7	1.7	-1.7
Reaction time trials correct on left	0.9	1.8	3.3	-1.8	1.5	-1.2	-0.1
Reaction time trials on left	0.9	1.8	3.3	-1.8	1.5	-1.2	-0.1
Reaction time mean	0.2	0.3	0.8	0.5	0.0	-0.6	0.9
Reaction time mean AUC	0.3	0.5	1.1	0.3	0.4	-0.9	1.1
Median of all reaction times	0.3	0.5	1.1	0.1	0.3	-0.8	1.1
Reaction time omissions	0.3	0.4	1.3	0.4	-0.3	0.1	-1.1
Reaction time false alarm rate	3.4	4.7	6.1	2.4	-2.5	2.2	-1.4
Reaction time premature initiation rate	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.1
Reaction time premature initiations	0.5	0.8	1.8	-1.3	0.9	-0.8	0.0
Std. dev. reaction times	0.4	0.7	2.2	1.5	-0.7	0.2	0.4
Reaction time trials completed	0.9	1.8	3.3	-1.8	1.5	-1.2	-0.1
Reaction time trials AUC	1.0	1.9	3.5	-1.9	1.6	-1.2	-0.1
Run reversals in cocaine runway, females	1.2	1.2	4.1	-0.3	0.4	-0.7	2.0
Run reversals in cocaine runway, males	0.5	0.5	1.6	1.3	-0.6	0.4	0.1
Latency to leave start box in cocaine runway	0.4	0.4	0.8	0.6	-0.9	0.7	-0.0
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	0.4	-0.8	0.5	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.2	0.3	-0.2
Std. dev. time between licks in bursts	2.6	3.5	5.6	2.4	-1.5	1.9	-1.6
Total sessions with >9 infusions	0.2	0.3	0.8	0.4	-0.4	0.1	0.9
Short access day 1 total inactive lever presses	0.4	0.5	1.4	0.8	-0.1	-0.1	1.2
Short access day 10 total inactive lever presses	1.4	3.5	11.6	-0.0	-1.0	1.2	-3.4
Short access day 1 total infusions	0.6	0.8	1.3	0.9	-0.9	0.4	1.1
Short access day 10 total infusions	0.0	0.1	0.1	0.1	-0.3	0.0	0.3
Short access total infusions	0.4	0.5	2.0	0.3	-0.2	-0.2	1.4
Short access day 1 locomotion	0.6	0.7	1.1	0.5	-0.9	0.9	-1.0
Short access day 10 total locomotion	0.5	1.0	2.6	0.4	-0.9	0.7	-1.6
Short access total locomotion	0.1	0.1	0.4	0.1	-0.4	0.2	-0.6
One hour access (0.3 mA shock)	2.2	2.6	3.9	1.6	-2.0	1.8	-0.7
Compulsive drug intake	1.9	2.3	3.5	0.9	-1.9	1.3	-1.7
One hour access (shock baseline)	0.4	0.6	1.8	0.7	-0.1	0.1	1.3
Social response proportion	0.1	0.1	0.1	0.3	-0.3	0.1	0.1
Social responses	0.3	0.4	1.4	0.2	-0.4	0.4	-1.2
Social time	2.7	3.7	9.3	1.2	-1.4	1.4	-3.0
Soleus weight	0.7	2.1	6.0	2.4	-1.2	0.9	-0.5
Bone: stiffness	0.7	1.1	1.7	-1.2	1.3	-1.1	-0.1
Tibialis anterior weight	0.2	0.7	1.2	0.4	-1.1	0.8	-0.8
Time to tail flick, vehicle, before self-admin	2.1	2.1	6.9	-0.9	1.0	-0.2	-2.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.4	-0.6	0.3	-0.2
Time to tail flick, test, before self-admin	1.0	1.0	2.7	0.2	-0.6	1.0	-1.6
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.8	-0.4	0.7	-0.5
Delta time to tail flick, vehicle, before/after SA	1.8	1.8	5.9	0.6	-0.9	0.1	2.4
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	-0.4	0.7	-0.7	0.5
Tibia length	0.6	1.7	3.1	-0.8	1.8	-1.6	-0.7
Ambulatory time before self-admin	0.2	0.3	1.3	-0.2	0.1	0.1	-1.1
Ambulatory time after self-admin	0.3	0.3	1.0	-0.4	0.0	-0.2	-1.0
Bone: tissue strength	0.7	0.7	1.4	-0.7	0.6	-0.9	1.2
Total heroin consumption	0.7	0.8	2.6	-0.0	-0.6	0.5	-1.6
Bone: trabecular number	0.1	0.1	0.3	0.2	-0.5	0.3	0.4
Bone: trabecular spacing	0.7	0.9	1.4	-1.0	1.2	-1.1	0.1
Bone: trabecular thickness	0.4	0.5	0.7	-0.4	0.7	-0.9	0.8
Bone: trabecular tissue density	0.2	0.3	0.8	0.9	-0.4	0.4	0.4
Water consumed over 24 hours	0.2	0.2	0.5	0.3	-0.7	0.5	-0.4
Number of responses in last shaping day	2.3	2.5	4.4	2.1	-1.5	1.3	1.2