Hub : Genes

Zfp324

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_82674660_82675044	0.25	0.1	1.6e-15	0.09	0.12	0.11	0.1	2.2e-10	7.4e-13	2.0e-12	1.4e-11
2	Liver	intron excision ratio	chr1_82674475_82675044	0.17	0.09	1.4e-11	0.08	0.1	0.1	0.09	1.7e-09	1.1e-10	4.9e-11	5.0e-10
3	PL	mRNA stability	Zfp324	0.03	0.02	8.4e-05	0.02	0.04	0.02	0.02	2.5e-03	9.2e-05	1.8e-03	1.3e-03
4	Liver	gene expression	Zfp324	0.11	0.06	9.3e-12	0.09	0.09	0.08	0.09	2.4e-10	2.9e-10	1.4e-09	2.6e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.6	-0.2	-0.2	-0.6	-0.8
Area under the delay curve	0.9	1.0	1.5	-1.2	0.7	0.9	1.1
BMI with tail	0.5	1.8	2.4	-1.1	1.4	1.6	1.2
BMI without tail	0.1	0.2	0.3	0.6	-0.2	0.5	0.4
Body weight	0.8	3.7	6.5	2.6	-2.1	-1.4	-1.4
Weight adjusted by age	0.4	0.5	1.0	0.2	-0.9	-1.0	-0.6
Bone surface	3.4	6.2	8.3	2.2	-2.3	-2.5	-2.9
Bone volume	3.0	5.3	7.4	2.1	-2.1	-2.3	-2.7
Breakpoint value in progressive ratio session	1.2	1.4	2.3	-0.6	0.8	1.5	1.5
Number of licking bursts	0.0	0.1	0.3	0.5	0.0	0.2	0.1
Context. condit. distance diff. score	0.1	0.1	0.3	-0.6	0.2	-0.1	0.0
Locomotion velocity, session 1	0.3	0.3	0.7	-0.0	-0.7	-0.9	-0.2
Locomotion distance, session 1	1.9	2.4	4.4	1.2	-1.6	-2.1	-1.1
Locomotion velocity, session 2	0.1	0.1	0.2	-0.0	-0.2	-0.5	-0.2
Locomotion distance, session 2	1.9	2.6	3.1	1.6	-1.7	-1.8	-1.5
Locomotion velocity, session 3	0.0	0.1	0.1	0.2	-0.0	-0.2	-0.4
Locomotion distance, session 3	0.7	0.8	1.5	-0.2	-0.4	-1.2	-1.2
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	0.3	0.2	0.7	0.9
Stereotopy head waving duration, day 3	0.4	0.5	1.4	0.3	0.2	0.7	1.2
Locomotion velocity, session 7	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.3
Locomotion distance, session 7	0.1	0.1	0.1	0.1	-0.3	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	0.7	-0.4	-0.5	-0.5
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.6	-0.4	-0.4	-0.3
Locomotion velocity, session 8	0.0	0.0	0.1	-0.0	-0.1	-0.4	-0.1
Locomotion distance, session 8	0.3	0.4	0.8	0.1	-0.5	-0.9	-0.6
Degree of sensitization distance	0.2	0.2	0.7	0.3	0.0	0.5	0.8
Degree of sensitization stereotypy	0.3	0.3	0.7	0.1	-0.2	-0.6	-0.9
Conditioned locomotion	0.0	0.0	0.1	-0.3	0.1	-0.1	0.3
Cocaine response after cond. corrected	0.5	0.6	1.6	0.3	0.4	1.3	0.7
Cocaine response after cond. not corrected	0.5	0.6	1.7	1.3	-0.8	-0.1	-0.4
Cocaine response before conditioning	4.5	5.4	7.9	1.8	-2.3	-2.8	-2.2
Saline control response	0.5	0.6	1.3	0.2	-0.2	-1.1	-1.0
Bone: connectivity density	0.1	0.2	0.5	-0.7	0.4	-0.2	-0.4
Bone: cortical apparent density	0.1	0.1	0.1	0.3	-0.3	0.3	0.3
Bone: cortical area	0.5	0.7	1.4	0.4	-0.7	-1.2	-0.9
Bone: cortical porosity	0.3	0.3	0.4	-0.3	0.7	0.6	0.5
Bone: cortical porosity	0.1	0.1	0.2	0.2	0.4	0.4	0.3
Bone: cortical thickness	0.4	0.7	1.0	-1.0	0.9	0.6	0.8
Bone: cortical thickness	0.2	0.3	0.4	0.5	-0.7	-0.4	-0.5
Bone: cortical tissue density	0.1	0.1	0.1	0.3	-0.3	0.4	0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.6	0.0	0.4	0.3
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.4	-0.7	1.1	1.2	1.1
Condit. Reinf. active responses	0.5	0.6	1.6	1.3	-0.7	-0.4	-0.6
Condit. Reinf. inactive responses	2.6	3.1	3.2	1.8	-1.8	-1.8	-1.7
Incentive salience index mean	0.3	0.4	0.9	0.9	-0.7	-0.3	-0.3
Condit. Reinf. lever presses	0.7	0.9	1.6	1.0	-1.2	-0.9	-0.7
Condit. Reinf. active minus inactive responses	2.8	3.6	4.9	1.5	-1.9	-2.2	-2.0
Condit. Reinf. active-inactive response ratio	3.2	3.7	4.3	1.8	-2.0	-2.1	-1.8
Condit. Reinf. active responses	2.4	3.3	5.2	1.1	-1.7	-2.3	-1.9
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.5	0.1	-0.4	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.2
Condit. Reinf. lever reinforcers received	3.2	4.4	6.8	1.3	-2.0	-2.6	-2.3
Conditioned reinforcement - actives	0.5	0.8	2.7	1.7	-0.6	0.2	0.1
Conditioned reinforcement - inactives	1.6	2.3	3.9	2.0	-1.7	-1.2	-0.9
Conditioned locomotion	0.2	0.3	1.0	1.0	-0.1	0.4	0.3
Patch foraging indifference point 0 sec	0.7	1.3	2.4	-1.5	1.1	0.7	1.2
Patch foraging indifference point AUC	0.4	0.5	0.7	-0.3	0.8	0.8	0.8
Delay disc. indifference point, 0s delay	0.6	0.7	2.1	-1.4	0.1	-0.8	-0.1
Delay disc. indifference point, 16s delay	0.9	1.0	2.4	-0.0	0.8	1.5	0.9
Delay disc. indifference point, 2s delay	0.4	0.4	0.8	-0.9	0.3	0.5	0.8
Delay disc. indifference point, 24s delay	0.6	0.7	1.5	-0.1	0.7	1.2	0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.4
Delay disc. indifference point, 8s delay	1.0	1.2	1.8	-1.4	0.7	0.9	1.3
Indifference point function ln k	3.4	5.9	7.8	1.9	-2.8	-2.8	-2.1
Indifference point function log k	3.4	5.9	7.8	1.9	-2.8	-2.8	-2.1
Patch foraging total patch changes 0 sec	0.7	1.3	2.2	-1.5	1.0	0.7	1.2
Patch foraging total patch changes 12 sec	0.4	0.5	0.8	-0.6	0.9	0.7	0.6
Patch foraging total patch changes 18 sec	0.8	1.2	2.0	-1.1	1.4	0.7	1.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	0.6	0.1	0.1	-0.3
Patch foraging total patch changes 6 sec	1.0	1.6	1.9	-1.0	1.3	1.4	1.3
Patch foraging time to switch 0 sec	1.5	3.0	6.7	-0.3	1.9	2.6	1.2
Patch foraging water rate 0 sec	0.3	0.7	1.8	0.0	-0.8	-1.4	-0.5
Patch foraging water rate 12 sec	0.8	1.6	3.7	0.3	-1.5	-1.9	-0.7
Patch foraging water rate 18 sec	0.2	0.4	0.8	0.1	-0.8	-0.9	-0.1
Patch foraging water rate 24 sec	0.5	0.7	1.6	0.4	-0.9	-1.3	-0.7
Patch foraging water rate 6 sec	6.3	9.2	10.0	3.1	-3.1	-3.2	-2.7
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	3.3	-1.8	0.3	-0.7	0.2
Distance traveled before self-admin	1.0	1.4	3.1	-0.3	-1.4	-1.7	-0.6
Distance traveled after self-admin	1.7	2.1	7.0	-2.6	0.9	-0.2	0.9
Extensor digitorum longus weight	0.2	0.6	0.7	0.8	-0.8	-0.7	-0.8
Bone: elastic displacement	1.5	1.7	2.1	-1.5	1.3	1.0	1.4
Bone: elastic work	0.1	0.1	0.3	-0.5	-0.1	-0.3	0.0
Bone: endosteal estimation	3.2	6.9	7.7	2.3	-2.7	-2.8	-2.8
Bone: endosteal perimeter	1.5	3.2	4.2	1.4	-1.8	-2.1	-1.9
Epididymis fat weight	0.0	0.1	0.3	0.4	0.2	0.6	-0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.5	0.3	-0.1	-0.1
Delta time in open arm before/after self-admin	1.0	1.0	1.8	1.4	-1.2	-0.7	-0.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.6	0.2	0.1	0.7
Delay discount exponential model param	0.7	0.8	1.1	1.1	-0.6	-0.8	-1.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.5	0.3	-0.2	-0.2
Active lever presses in extinction session 6	0.5	0.5	1.4	1.2	-0.2	0.6	-0.2
Bone: final force	2.2	3.5	3.9	1.6	-2.0	-2.0	-1.9
Bone: final moment	2.7	4.4	5.4	1.7	-2.2	-2.3	-2.1
Food consumed during 24 hour testing period	0.3	0.4	0.7	0.5	-0.8	-0.6	-0.3
Glucose	1.9	3.0	4.2	-2.0	1.5	1.5	1.8
Heart weight	0.5	0.8	1.9	1.4	-1.1	-0.4	-0.3
Delay discount hyperbolic model param	0.9	1.0	1.4	1.2	-0.7	-0.9	-1.1
Intermittent access intake day 1-15 change	0.5	1.0	2.6	1.6	-1.0	-0.4	-0.4
Intermittent access intake escalation	0.8	1.7	4.5	2.1	-1.3	-0.5	-0.6
Intermittent access intake escalation 2	0.0	0.1	0.1	0.2	-0.3	-0.2	0.2
Intermitt. access day 1 inactive lever presses	0.6	2.4	6.6	2.6	-1.6	-0.2	-0.4
Intermitt. access day 15 inactive lever presses	1.6	3.2	6.9	2.6	-1.8	-1.0	-1.2
Intermitt. access escalation Index	0.5	0.7	1.1	-0.6	0.7	1.1	1.0
Intermittent access day 1 total infusions	0.4	0.7	1.8	1.3	-0.8	-0.3	-0.5
Intermittent access day 15 total infusions	1.2	1.7	5.4	2.3	-1.2	0.1	-0.1
Intermittent access terminal intake (last 3 days)	1.0	1.3	3.8	2.0	-1.1	-0.1	-0.2
Intermittent access total infusions	1.7	2.0	5.2	2.3	-1.5	-0.4	-0.6
Intermittent access day 1 locomotion	1.0	1.3	2.7	1.7	-1.2	-0.5	-0.7
Intermittent access day 15 total locomotion	0.4	0.7	1.4	1.1	-1.2	-0.5	0.1
Intermittent access total locomotion	2.6	3.1	6.0	2.4	-2.0	-1.2	-1.1
Intermittent access standard deviation	0.4	0.9	1.9	-0.3	0.6	1.1	1.4
Left kidney weight	4.4	20.3	26.7	5.2	-4.9	-4.2	-3.6
Right kidney weight	4.1	18.8	27.2	5.2	-4.6	-3.8	-3.4
Cocaine induced anxiety	0.9	1.4	1.7	1.3	-1.2	-1.1	-1.1
Post-drug Anxiety	1.1	1.2	2.1	1.4	-1.0	-0.7	-1.2
Baseline Anxiety	0.4	0.5	1.0	-1.0	0.7	0.6	0.4
Tail length	2.3	9.0	12.2	3.5	-3.3	-2.7	-2.3
Length with tail	2.7	11.7	16.4	4.0	-3.6	-3.0	-2.9
Length without tail	1.9	6.0	11.1	3.3	-2.3	-1.7	-2.2
Times rat made contact with spout	0.3	0.3	0.8	-0.9	0.7	0.3	0.2
Lifetime Intake	1.3	1.6	4.1	2.0	-1.3	-0.4	-0.6
Liver weight, left	1.5	2.5	4.3	2.1	-1.6	-1.2	-1.2
Liver weight, right	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2
Locomotor activity	0.2	0.3	0.4	-0.5	0.5	0.6	0.5
Locomotor testing distance	0.0	0.0	0.1	0.3	0.0	0.2	-0.0
Locomotor testing rearing	0.2	0.3	0.5	0.7	-0.5	-0.7	-0.5
Locomotion in novel chamber	0.7	0.9	1.7	-1.3	1.1	0.8	0.6
Locomotion in novel chamber post-restriction	0.7	1.1	2.4	-1.5	1.0	0.7	0.7
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.1	-0.2	-0.4	0.1
Change in fecal boli incidents, locomotor task	2.7	2.7	3.2	-1.8	1.6	1.5	1.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	0.2	0.2	0.6	0.1
Bouts of movement, locomotor time 1	0.4	0.4	1.1	-1.0	-0.3	-0.7	0.2
Total resting periods, locomotor time 1	0.3	0.3	1.2	-1.1	0.0	-0.3	0.4
Rest time, locomotor task time 1	0.8	1.0	1.3	0.7	-1.0	-1.1	-1.1
Distance moved, locomotor task time 1	0.6	0.9	1.1	-0.8	0.9	1.1	1.0
Vertical activity count, locomotor time 1	1.4	3.4	5.8	-2.4	1.5	1.4	1.9
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.7	-0.3	0.8	0.8	0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.5	0.0	-0.2	-0.4
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.5	-0.0	-0.3	-0.6
Rest time, locomotor task time 2	0.3	0.3	1.1	-1.0	0.0	-0.5	-0.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	0.2	0.2	0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.8	0.4	0.2	0.5
Light reinforcement 1	0.1	0.2	0.3	-0.6	-0.1	-0.5	-0.2
Light reinforcement 2	0.5	0.7	1.0	-0.6	0.9	1.0	0.8
Bone: marrow area	3.2	7.0	7.7	2.3	-2.7	-2.8	-2.8
Bone: maximum diameter	0.5	0.9	1.5	0.8	-0.9	-1.2	-0.9
Bone: maximum force	2.0	3.5	4.3	1.4	-1.9	-2.1	-2.0
Bone: maximum moment	2.4	4.2	5.6	1.4	-2.0	-2.4	-2.2
Mean time between licks in bursts	0.3	0.8	1.1	-1.1	0.7	0.8	0.9
Mean num. licks in bursts	0.2	0.2	0.8	-0.9	0.3	-0.1	-0.1
Cd content in liver	1.2	1.3	1.7	1.2	-1.3	-1.2	-0.9
Co content in liver	0.7	0.8	1.2	1.1	-1.1	-0.8	-0.5
Cu content in liver	2.7	3.1	5.4	2.3	-1.7	-1.3	-1.6
Fe content in liver	0.9	1.1	3.0	1.7	-0.9	-0.4	-0.7
K content in liver	0.1	0.1	0.3	0.6	-0.2	-0.3	-0.1
Mg content in liver	0.1	0.1	0.4	0.6	0.0	0.2	0.2
Mn content in liver	0.1	0.1	0.2	0.4	0.2	0.3	0.1
Na content in liver	0.9	0.9	1.3	-0.7	1.1	1.0	0.9
Rb content in liver	3.4	3.9	5.5	2.4	-2.0	-1.8	-1.8
Se content in liver	1.6	1.9	2.6	-0.9	1.4	1.6	1.5
Sr content in liver	8.8	7.6	11.9	-3.4	2.7	2.1	2.6
Zn content in liver	0.3	0.3	0.7	0.7	0.2	0.8	0.4
Bone: minimum diameter	2.4	4.4	7.1	1.4	-1.9	-2.7	-2.2
Time in familiar zone, hab. session 1	2.9	2.8	4.4	0.6	-1.9	-2.1	-1.6
Time in novel zone, hab. session 1	1.3	1.3	2.3	0.0	1.4	1.5	1.0
Total zone transitions, hab. session 1	1.6	2.3	3.8	0.8	-1.5	-2.0	-1.5
Total locomotion distance, hab. session 1	0.2	0.4	0.8	-0.6	-0.4	-0.9	-0.3
Locomotion velocity, hab. session 1	0.2	0.2	0.5	-0.5	-0.4	-0.7	-0.2
Time in familiar zone, hab. session 2	2.2	2.4	2.7	1.6	-1.6	-1.2	-1.7
Time in novel zone, hab. session 2	0.9	1.0	1.4	-0.8	1.2	0.9	1.0
Total zone transitions, hab. session 2	1.6	2.1	4.5	0.7	-1.4	-2.1	-1.1
Total locomotion distance, hab. session 2	0.5	0.6	1.8	-1.3	0.3	-0.3	0.6
Locomotion velocity, hab. session 2	0.6	0.8	2.2	-1.5	0.4	-0.2	0.8
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.5	0.2	-0.1	0.3
Novelty place preference	0.0	0.0	0.1	-0.1	-0.2	-0.4	-0.0
Time in novel zone, NPP test	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.1
Total zone transitions, NPP test	0.1	0.1	0.4	-0.1	-0.3	-0.6	-0.2
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.9	0.4	-0.0	0.7
Locomotion velocity, NPP test	0.2	0.3	0.8	-0.9	0.3	-0.2	0.6
Intraocular pressure	0.1	0.1	0.2	0.3	-0.1	-0.2	-0.4
Delta distance traveled before/after self-admin	2.7	2.8	3.4	-1.8	1.8	1.5	1.6
Delta ambulatory time before/after self-admin	2.0	2.5	2.8	-1.7	1.6	1.4	1.6
Parametrial fat weight	2.6	6.2	7.0	-2.5	2.4	2.4	2.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.1	0.3	0.1	-0.0
Pavlov. Cond. magazine entry latency	0.8	1.0	1.1	-1.0	1.0	1.0	1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.6	0.3	0.3	0.5
Pavlov. Cond. index score	0.2	0.3	0.4	-0.6	0.4	0.5	0.6
Pavlov. Cond. latency score	0.3	0.3	0.5	-0.6	0.4	0.5	0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.2	-0.3	-0.0	-0.1
Pavlov. Cond. magazine entry number	0.3	0.3	0.6	0.8	-0.6	-0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.0	-0.2	-0.6	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	-0.6	0.4	0.6	0.7
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.1	0.1	0.2	0.1
Pavlov. Cond. lever latency	1.5	2.1	4.3	2.1	-1.5	-0.7	-1.2
Pavlov. Cond. magazine entry latency	2.1	2.5	3.2	-1.8	1.8	1.3	1.4
Pavlov. Cond. change in total contacts	0.2	0.4	1.2	-1.1	0.4	-0.5	-0.2
Pavlov. Cond. index score	0.8	1.1	2.4	-1.5	1.2	0.5	0.7
Pavlov. Cond. latency score	1.6	2.1	3.7	-1.9	1.6	1.0	1.2
Pavlov. Cond. lever contacts	1.0	1.4	3.1	-1.7	1.2	0.4	0.9
Pavlov. Cond. magazine entry number	1.0	1.3	2.3	1.5	-1.3	-0.9	-0.7
Pavlov. Cond. intertrial magazine entries	4.2	6.3	7.2	2.5	-2.7	-2.5	-2.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	2.4	-1.5	1.1	0.5	0.7
Pavlov. Cond. response bias	0.3	0.4	1.3	-1.1	0.6	-0.2	0.1
Time in closed arm before self-admin	0.5	0.6	1.5	1.2	-1.0	-0.2	0.0
Time in closed arm after self-admin	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.3
Time in open arm before self-admin	1.6	1.8	4.0	-2.0	1.6	0.6	0.5
Time in open arm after self-admin	0.2	0.2	0.5	-0.7	0.4	0.0	0.1
Bone: periosteal estimation	2.1	4.4	6.2	1.5	-2.0	-2.5	-2.3
Bone: periosteal perimeter	2.2	3.7	5.3	1.3	-1.7	-2.2	-2.3
Bone: post-yield work	2.8	4.2	5.7	2.0	-1.8	-1.9	-2.4
Progressive ratio test 1 active lever presses	0.5	0.7	1.0	0.7	-0.9	-1.0	-0.7
Progressive ratio test 1 breakpoint	0.5	0.6	0.9	0.6	-0.9	-1.0	-0.6
Progressive ratio test 1 inactive lever presses	2.7	3.9	6.4	2.5	-2.2	-1.4	-1.4
Progressive ratio test 2 active lever presses	0.9	1.0	3.3	1.8	-0.8	0.1	0.0
Progressive ratio test 2 breakpoint	1.0	1.2	3.9	2.0	-0.9	0.1	-0.1
Progressive ratio test 2 inactive lever presses	2.6	4.2	7.7	2.8	-2.3	-1.5	-1.3
Incentive Sensitization - Responses	1.5	2.1	6.7	2.6	-1.2	-0.1	-0.3
Incentive Sensitization - Breakpoint	1.3	1.7	5.7	2.4	-1.0	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	-0.5	0.2	0.4	0.8
Progressive ratio	0.1	0.2	0.8	-0.9	0.2	-0.2	0.2
Food seeking constrained by brief footshock	3.2	4.0	13.2	-3.6	0.6	-1.2	0.9
Seeking ratio, punishment vs. effort	0.2	0.3	0.8	-0.4	-0.5	-0.9	-0.3
Retroperitoneal fat weight	4.1	17.4	23.0	-3.5	4.3	4.8	4.0
Reaction time number correct	0.3	0.6	1.5	-1.2	0.6	0.2	0.5
Reaction time mean minus median	0.0	0.1	0.1	0.3	-0.2	0.1	-0.2
Reaction time mean minus median AUC	0.0	0.1	0.2	0.4	-0.2	-0.1	-0.4
Reaction time num false alarms	0.1	0.1	0.3	0.3	-0.1	0.3	0.6
Reaction time num false alarms AUC	0.2	0.2	0.6	-0.3	0.3	0.4	0.8
Reaction time trials correct on left	0.3	0.6	1.5	-1.2	0.6	0.2	0.5
Reaction time trials on left	0.3	0.6	1.5	-1.2	0.6	0.2	0.6
Reaction time mean	0.9	1.5	3.3	1.8	-1.3	-0.4	-0.9
Reaction time mean AUC	0.5	0.8	2.1	1.5	-0.9	0.0	-0.5
Median of all reaction times	1.0	1.5	3.5	1.9	-1.2	-0.4	-0.9
Reaction time omissions	0.0	0.1	0.1	-0.2	0.1	0.1	0.4
Reaction time false alarm rate	0.1	0.1	0.3	0.2	-0.0	0.3	0.5
Reaction time premature initiation rate	0.1	0.2	0.3	-0.5	0.3	0.4	0.6
Reaction time premature initiations	0.4	0.7	1.2	-1.1	0.8	0.6	0.9
Std. dev. reaction times	0.3	0.5	1.3	1.1	-0.9	-0.2	-0.3
Reaction time trials completed	0.3	0.6	1.5	-1.2	0.6	0.2	0.6
Reaction time trials AUC	0.3	0.6	1.4	-1.2	0.7	0.3	0.6
Run reversals in cocaine runway, females	0.2	0.2	0.5	0.7	0.1	0.6	0.2
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.7	-0.4	-0.3	-0.7
Latency to leave start box in cocaine runway	0.2	0.3	0.9	0.9	-0.4	-0.2	-0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.3	0.3	0.3	0.5
Latency to leave start box in cocaine runway, M	2.0	1.9	2.9	1.7	-1.4	-1.1	-1.2
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.1
Total sessions with >9 infusions	1.6	1.9	2.6	1.6	-1.4	-1.3	-1.3
Short access day 1 total inactive lever presses	1.4	1.8	4.5	2.1	-1.3	-0.6	-0.9
Short access day 10 total inactive lever presses	0.0	0.1	0.3	0.5	-0.4	-0.2	-0.1
Short access day 1 total infusions	0.2	0.3	0.5	0.7	-0.5	-0.3	-0.5
Short access day 10 total infusions	0.1	0.1	0.3	0.5	-0.4	0.2	0.1
Short access total infusions	0.0	0.0	0.1	0.3	-0.1	0.1	0.0
Short access day 1 locomotion	1.3	1.6	3.9	2.0	-0.9	-0.7	-1.1
Short access day 10 total locomotion	0.4	0.7	1.1	0.8	-1.0	-1.0	-0.6
Short access total locomotion	0.2	0.3	0.6	0.1	-0.6	-0.8	-0.3
One hour access (0.3 mA shock)	4.1	4.7	10.2	3.2	-2.3	-1.2	-1.4
Compulsive drug intake	2.3	2.7	4.5	2.1	-1.7	-1.2	-1.4
One hour access (shock baseline)	0.5	0.8	2.7	1.7	-0.6	0.3	0.1
Social response proportion	1.6	1.8	4.7	2.2	-1.5	-0.3	-0.6
Social responses	4.2	5.4	9.2	3.0	-2.5	-1.6	-1.9
Social time	2.5	3.5	5.2	1.2	-2.2	-2.3	-1.5
Soleus weight	0.0	0.0	0.1	-0.2	-0.0	0.1	-0.1
Bone: stiffness	2.4	3.9	4.4	2.1	-2.0	-1.9	-1.9
Tibialis anterior weight	1.0	3.3	4.1	-2.0	1.9	1.8	1.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.1	-0.3	-0.2	0.2
Time to tail flick, vehicle, after self-admin	0.7	0.9	2.3	1.5	-0.8	-0.4	-0.9
Time to tail flick, test, before self-admin	0.9	0.9	3.0	-1.7	0.3	-0.6	0.3
Time to tail flick, test, after self-admin	0.3	0.4	0.7	-0.5	0.8	0.5	0.5
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.9	1.0	-0.3	-0.1	-0.7
Delta time to tail flick, test, before/after SA	0.4	0.4	1.5	1.2	-0.0	0.5	-0.1
Tibia length	3.0	8.4	10.0	2.7	-2.9	-3.2	-2.8
Ambulatory time before self-admin	1.0	1.5	3.4	-0.1	-1.3	-1.8	-1.0
Ambulatory time after self-admin	0.9	1.0	3.3	-1.8	0.3	-0.6	0.5
Bone: tissue strength	0.3	0.3	1.0	-1.0	0.1	-0.1	0.5
Total heroin consumption	0.2	0.2	0.3	-0.5	0.5	0.2	0.5
Bone: trabecular number	0.2	0.4	1.1	-1.1	0.5	-0.1	-0.4
Bone: trabecular spacing	0.0	0.0	0.0	-0.1	0.1	0.1	0.2
Bone: trabecular thickness	0.0	0.0	0.1	0.3	-0.1	0.0	-0.2
Bone: trabecular tissue density	0.8	1.2	2.6	0.1	0.9	1.6	1.2
Water consumed over 24 hours	0.5	0.7	1.2	0.2	-0.8	-1.1	-1.0
Number of responses in last shaping day	0.8	0.9	2.9	1.7	-0.6	0.3	-0.2