Hub : Genes

Zfp296

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Zfp296 0.45 0.11 0.0e+00 0.5 0.51 0.5 0.5 2.1e-63 4.4e-65 6.0e-63 4.2e-63
2 NAcc gene expression Zfp296 0.24 0.1 0.0e+00 0.29 0.29 0.29 0.28 1.5e-44 9.9e-45 1.6e-44 4.2e-43
3 RMTg gene expression Zfp296 0.26 0.14 4.2e-07 0.13 0.16 0.16 0.17 2.8e-04 6.1e-05 6.2e-05 2.1e-05
4 BLA gene expression Zfp296 0.45 0.15 0.0e+00 0.35 0.37 0.35 0.36 1.5e-19 9.7e-21 2.9e-19 1.0e-19
5 IL gene expression Zfp296 0.61 0.21 1.1e-10 0.38 0.36 0.34 0.37 4.7e-10 1.6e-09 5.9e-09 8.4e-10
6 OFC gene expression Zfp296 0.37 0.14 1.9e-09 0.35 0.33 0.32 0.34 3.4e-09 1.1e-08 1.8e-08 9.1e-09
7 pVTA gene expression Zfp296 0.28 0.15 0.0e+00 0.19 0.2 0.18 0.19 3.9e-15 1.2e-15 2.7e-14 2.3e-15
8 LHb gene expression Zfp296 0.45 0.15 7.8e-12 0.48 0.45 0.48 0.48 5.5e-13 4.4e-12 6.8e-13 4.4e-13
9 Brain gene expression Zfp296 0.52 0.16 0.0e+00 0.51 0.51 0.51 0.51 1.2e-54 3.0e-55 5.2e-55 5.4e-55
10 IC gene expression Zfp296 0.33 0.16 3.6e-12 0.25 0.21 0.23 0.23 9.8e-11 3.8e-09 7.1e-10 3.6e-10
11 Adipose gene expression Zfp296 0.39 0.17 0.0e+00 0.32 0.31 0.32 0.32 1.3e-36 1.0e-34 8.9e-37 7.3e-36
12 Liver gene expression Zfp296 0.09 0.05 1.1e-13 0.11 0.11 0.11 0.11 5.9e-12 5.9e-12 4.4e-12 8.0e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.10.3-0.1-0.0-0.1-0.10.20.2-0.2-0.2-0.4-0.5-0.3-0.0
Area under the delay curve1.82.13.31.41.51.41.31.31.31.41.61.41.71.81.2
BMI with tail0.62.02.7-1.4-1.2-1.6-1.5-1.3-1.3-1.6-1.5-1.6-1.7-1.5-1.0
BMI without tail0.61.72.1-1.4-1.3-1.4-1.4-1.3-1.3-1.3-1.4-1.2-1.0-1.1-1.2
Body weight1.15.06.7-2.2-2.0-2.3-2.3-2.1-2.1-2.3-2.2-2.5-2.6-2.3-1.8
Weight adjusted by age0.00.00.00.0-0.1-0.0-0.0-0.1-0.1-0.0-0.00.1-0.2-0.00.0
Bone surface0.40.71.2-0.8-0.6-0.8-0.8-0.6-0.6-0.8-0.8-1.0-1.1-1.0-0.6
Bone volume0.30.51.0-0.7-0.5-0.6-0.6-0.4-0.4-0.7-0.7-1.0-1.0-0.9-0.4
Breakpoint value in progressive ratio session2.22.73.21.71.81.71.61.61.61.61.61.51.51.61.6
Number of licking bursts1.82.94.4-1.7-1.6-1.7-1.8-2.1-2.1-1.7-1.4-1.6-1.5-1.5-1.6
Context. condit. distance diff. score0.10.10.2-0.3-0.2-0.3-0.4-0.3-0.3-0.4-0.4-0.5-0.4-0.40.0
Locomotion velocity, session 10.10.10.20.30.50.30.20.30.30.20.30.1-0.40.10.4
Locomotion distance, session 10.10.20.6-0.2-0.2-0.4-0.3-0.1-0.1-0.3-0.3-0.6-0.7-0.6-0.7
Locomotion velocity, session 21.01.11.6-1.1-1.2-1.0-1.1-1.3-1.3-1.0-1.0-0.8-1.1-1.0-0.8
Locomotion distance, session 20.40.50.9-0.7-0.8-0.7-0.7-0.5-0.5-0.7-0.8-0.7-0.9-0.9-0.7
Locomotion velocity, session 30.20.20.4-0.5-0.6-0.4-0.4-0.5-0.5-0.4-0.5-0.3-0.3-0.4-0.2
Locomotion distance, session 30.80.81.40.90.61.01.00.90.90.90.91.20.90.80.8
Stereotopy head waving bouts, day 30.70.81.5-0.9-1.1-0.9-0.9-1.1-1.1-0.8-0.7-0.3-0.4-0.5-1.2
Stereotopy head waving duration, day 30.91.11.7-1.1-1.1-1.2-1.1-1.2-1.2-1.1-1.0-0.8-0.6-0.8-1.3
Locomotion velocity, session 70.10.10.20.40.30.40.30.40.40.20.10.10.40.1-0.0
Locomotion distance, session 70.10.10.4-0.1-0.1-0.1-0.3-0.2-0.2-0.3-0.4-0.4-0.6-0.40.3
Stereotopy head waving bouts, day 70.91.01.2-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.9-0.7-1.0-1.1
Stereotopy head waving duration, day 70.60.80.9-0.9-0.9-0.9-0.9-1.0-1.0-0.9-0.9-0.8-0.6-0.8-0.8
Locomotion velocity, session 80.10.10.30.1-0.10.20.10.00.00.20.20.40.60.40.3
Locomotion distance, session 80.10.10.4-0.2-0.1-0.1-0.20.00.0-0.2-0.4-0.4-0.6-0.40.1
Degree of sensitization distance0.70.71.2-0.7-0.5-0.9-0.9-0.8-0.8-0.9-0.9-1.1-1.0-0.7-0.4
Degree of sensitization stereotypy1.01.01.2-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.8-1.1-1.0
Conditioned locomotion0.10.10.40.3-0.10.20.30.20.20.30.30.60.40.1-0.2
Cocaine response after cond. corrected0.60.81.2-0.7-0.8-0.8-0.8-0.8-0.8-0.9-0.9-0.8-1.1-1.1-0.7
Cocaine response after cond. not corrected1.61.92.8-1.2-1.3-1.4-1.3-1.3-1.3-1.4-1.4-1.3-1.7-1.7-1.0
Cocaine response before conditioning1.41.72.2-1.3-1.5-1.4-1.3-1.3-1.3-1.3-1.4-1.1-1.3-1.3-0.9
Saline control response2.02.73.9-1.8-1.7-1.6-1.6-1.7-1.7-1.6-1.6-1.6-1.3-1.5-2.0
Bone: connectivity density0.00.00.10.00.10.00.10.40.4-0.0-0.0-0.2-0.1-0.1-0.2
Bone: cortical apparent density0.10.10.30.20.30.40.30.40.40.30.20.10.50.30.3
Bone: cortical area1.52.32.8-1.7-1.5-1.5-1.6-1.6-1.6-1.5-1.5-1.6-1.4-1.5-1.3
Bone: cortical porosity0.40.41.60.60.20.70.70.30.30.70.71.20.30.50.5
Bone: cortical porosity0.10.10.70.2-0.20.30.3-0.1-0.10.30.30.80.10.2-0.0
Bone: cortical thickness0.60.91.2-1.1-1.1-1.0-1.0-1.0-1.0-1.0-1.0-0.9-0.7-0.9-1.1
Bone: cortical thickness1.51.72.6-1.4-1.4-1.4-1.3-1.3-1.3-1.3-1.3-1.2-1.6-1.4-0.8
Bone: cortical tissue density0.10.20.40.40.40.50.40.60.60.40.30.20.60.40.4
Condit. Reinf. active minus inactive responses0.40.40.7-0.6-0.6-0.7-0.7-0.5-0.5-0.8-0.7-0.8-0.8-0.8-0.2
Condit. Reinf. active-inactive response ratio0.40.40.8-0.6-0.5-0.7-0.6-0.3-0.3-0.7-0.8-0.9-0.8-0.8-0.1
Condit. Reinf. active responses0.30.40.7-0.6-0.5-0.7-0.6-0.4-0.4-0.7-0.7-0.7-0.8-0.8-0.1
Condit. Reinf. inactive responses0.00.00.1-0.0-0.0-0.00.10.30.30.0-0.1-0.0-0.1-0.10.2
Incentive salience index mean0.20.30.4-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.5-0.5-0.6-0.7-0.4
Condit. Reinf. lever presses0.00.10.5-0.0-0.20.1-0.0-0.0-0.0-0.1-0.1-0.1-0.3-0.3-0.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.3-0.5-0.4-0.2-0.2-0.4-0.4-0.4-0.5-0.5-0.0
Condit. Reinf. active-inactive response ratio0.60.71.2-0.7-0.8-0.9-0.7-0.6-0.6-0.9-0.9-0.8-1.0-1.1-0.4
Condit. Reinf. active responses0.10.10.20.30.20.20.30.40.40.30.30.40.40.40.5
Condit. Reinf. inactive responses0.81.11.70.90.91.01.01.01.01.01.01.11.31.31.0
Condit. Reinf. lever presses0.20.20.5-0.4-0.3-0.6-0.6-0.4-0.4-0.6-0.5-0.7-0.6-0.4-0.2
Condit. Reinf. lever reinforcers received0.10.10.20.40.30.30.40.40.40.40.30.50.50.40.4
Conditioned reinforcement - actives1.32.22.8-1.6-1.7-1.6-1.5-1.4-1.4-1.5-1.6-1.3-1.2-1.3-1.5
Conditioned reinforcement - inactives0.40.50.8-0.7-0.9-0.8-0.7-0.8-0.8-0.7-0.8-0.6-0.6-0.6-0.9
Conditioned locomotion2.33.03.5-1.7-1.8-1.9-1.8-1.7-1.7-1.8-1.8-1.6-1.8-1.8-1.5
Patch foraging indifference point 0 sec0.40.71.1-0.8-0.9-0.9-0.9-0.8-0.8-0.8-0.7-0.8-1.0-0.9-0.8
Patch foraging indifference point AUC2.63.85.3-2.0-2.1-2.0-2.0-2.2-2.2-1.9-2.0-1.7-1.1-1.6-2.3
Delay disc. indifference point, 0s delay1.41.52.11.21.11.21.31.21.21.31.31.41.31.30.8
Delay disc. indifference point, 16s delay1.31.42.31.01.21.11.01.21.21.11.31.01.41.51.2
Delay disc. indifference point, 2s delay3.74.25.52.22.32.12.01.81.82.12.31.92.12.31.6
Delay disc. indifference point, 24s delay0.20.20.6-0.3-0.1-0.4-0.5-0.2-0.2-0.5-0.4-0.7-0.8-0.40.5
Delay disc. indifference point, 4s delay0.00.00.10.10.0-0.10.0-0.1-0.10.10.10.30.20.3-0.2
Delay disc. indifference point, 8s delay1.82.23.41.31.51.41.41.31.31.41.61.41.81.81.2
Indifference point function ln k0.71.11.91.01.11.11.11.31.31.01.00.80.70.91.4
Indifference point function log k0.71.11.91.01.11.11.11.31.31.01.00.80.70.91.4
Patch foraging total patch changes 0 sec0.71.32.0-1.1-1.1-1.2-1.1-1.0-1.0-1.1-1.0-1.2-1.4-1.2-1.0
Patch foraging total patch changes 12 sec1.11.52.1-1.1-1.3-1.3-1.2-1.4-1.4-1.2-1.1-0.9-0.8-1.1-1.5
Patch foraging total patch changes 18 sec2.03.13.8-1.7-1.6-1.9-1.8-1.7-1.7-1.8-1.7-2.0-1.8-1.8-1.6
Patch foraging total patch changes 24 sec0.30.60.9-0.7-0.7-0.9-0.8-0.7-0.7-0.8-0.7-0.7-0.5-0.7-0.9
Patch foraging total patch changes 6 sec2.43.64.7-2.0-2.2-2.0-1.9-1.9-1.9-1.8-1.9-1.6-1.6-1.7-2.2
Patch foraging time to switch 0 sec2.75.66.42.52.52.42.42.22.22.42.42.32.12.42.4
Patch foraging water rate 0 sec3.06.37.5-2.5-2.7-2.6-2.5-2.4-2.4-2.6-2.6-2.4-2.1-2.5-2.7
Patch foraging water rate 12 sec0.20.50.8-0.7-0.6-0.7-0.6-0.4-0.4-0.7-0.7-0.8-0.8-0.7-0.9
Patch foraging water rate 18 sec0.20.30.6-0.6-0.5-0.5-0.5-0.4-0.4-0.5-0.6-0.7-0.7-0.5-0.6
Patch foraging water rate 24 sec0.60.91.1-1.0-1.0-1.0-1.0-0.9-0.9-1.0-1.0-1.0-0.7-0.9-0.9
Patch foraging water rate 6 sec0.81.22.2-1.1-0.9-1.1-1.1-0.9-0.9-1.2-1.2-1.5-1.0-1.1-1.0
Seeking ratio, delayed vs. immediate footshock1.92.32.71.51.31.51.61.61.61.51.41.61.71.51.4
Distance traveled before self-admin0.10.10.2-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.4-0.3-0.4-0.3
Distance traveled after self-admin0.20.20.70.30.30.40.50.40.40.50.40.50.80.50.4
Extensor digitorum longus weight1.87.08.5-2.8-2.4-2.6-2.7-2.8-2.8-2.6-2.5-2.9-2.9-2.7-2.2
Bone: elastic displacement1.01.21.41.21.11.21.21.11.11.11.01.20.61.01.1
Bone: elastic work0.00.00.2-0.1-0.3-0.1-0.1-0.1-0.1-0.1-0.20.1-0.5-0.2-0.1
Bone: endosteal estimation0.00.00.20.20.30.20.20.20.20.10.10.0-0.10.00.5
Bone: endosteal perimeter0.00.00.00.00.20.10.0-0.0-0.0-0.00.1-0.2-0.1-0.00.2
Epididymis fat weight0.31.01.30.91.01.11.00.90.91.01.01.01.01.11.2
Delta time in closed arm before/after self-admin0.10.10.10.20.30.20.20.40.40.20.20.00.10.20.2
Delta time in open arm before/after self-admin0.00.00.10.10.00.20.20.10.10.20.10.30.30.20.4
Diff in mean of infusions in LGA sessions1.31.62.01.41.41.31.31.31.31.31.21.21.21.31.1
Delay discount exponential model param1.31.52.4-1.1-1.3-1.1-1.1-1.1-1.1-1.2-1.4-1.1-1.4-1.5-1.0
Extinction: sum of active levers before priming0.10.10.30.30.20.30.30.20.20.30.10.60.20.3-0.0
Active lever presses in extinction session 60.20.20.80.0-0.1-0.2-0.3-0.2-0.2-0.3-0.3-0.4-0.9-0.5-0.4
Bone: final force0.40.60.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.7-0.9-0.8-0.6
Bone: final moment0.50.91.0-0.9-0.9-1.0-1.0-0.9-0.9-1.0-0.9-0.8-0.9-1.0-0.8
Food consumed during 24 hour testing period4.66.37.62.62.52.52.52.82.82.52.42.42.32.42.6
Glucose0.30.50.80.80.70.60.60.60.60.60.70.90.80.80.4
Heart weight2.13.23.6-1.8-1.8-1.8-1.8-1.9-1.9-1.8-1.8-1.7-1.7-1.7-1.7
Delay discount hyperbolic model param1.21.42.3-1.1-1.3-1.1-1.1-1.0-1.0-1.2-1.3-1.1-1.4-1.5-0.9
Intermittent access intake day 1-15 change0.10.20.4-0.4-0.3-0.4-0.5-0.4-0.4-0.4-0.4-0.5-0.6-0.4-0.3
Intermittent access intake escalation0.10.30.4-0.5-0.4-0.6-0.6-0.5-0.5-0.5-0.5-0.6-0.6-0.5-0.4
Intermittent access intake escalation 20.00.00.0-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.0-0.2-0.1-0.2
Intermitt. access day 1 inactive lever presses0.00.00.3-0.0-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.4-0.1-0.6
Intermitt. access day 15 inactive lever presses0.00.00.1-0.10.1-0.0-0.1-0.0-0.0-0.1-0.0-0.4-0.20.0-0.1
Intermitt. access escalation Index0.20.30.40.60.60.70.60.60.60.60.60.50.40.5-0.2
Intermittent access day 1 total infusions1.42.22.8-1.6-1.7-1.6-1.5-1.5-1.5-1.5-1.6-1.3-0.9-1.1-1.6
Intermittent access day 15 total infusions0.71.11.4-1.1-1.0-1.2-1.1-1.1-1.1-1.1-1.1-1.1-0.8-0.8-1.0
Intermittent access terminal intake (last 3 days)1.11.51.8-1.3-1.2-1.3-1.3-1.2-1.2-1.3-1.3-1.2-1.0-1.0-1.2
Intermittent access total infusions2.42.93.4-1.8-1.7-1.8-1.8-1.7-1.7-1.8-1.8-1.6-1.4-1.4-1.6
Intermittent access day 1 locomotion0.30.40.9-0.6-0.8-0.7-0.6-0.6-0.6-0.6-0.7-0.4-0.3-0.5-0.9
Intermittent access day 15 total locomotion0.10.20.3-0.5-0.6-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.2-0.2-0.6
Intermittent access total locomotion1.61.92.5-1.4-1.5-1.6-1.5-1.4-1.4-1.5-1.5-1.2-0.9-1.1-1.4
Intermittent access standard deviation0.10.20.30.50.50.40.40.40.40.40.40.50.10.40.4
Left kidney weight5.525.627.9-5.3-5.3-5.2-5.1-4.9-4.9-5.2-5.3-5.0-5.2-5.2-4.0
Right kidney weight5.123.224.7-4.9-4.9-4.9-4.9-4.7-4.7-4.9-4.9-4.8-4.9-5.0-4.1
Cocaine induced anxiety0.20.30.60.50.60.50.50.50.50.60.60.50.70.80.2
Post-drug Anxiety0.10.10.10.20.30.30.20.10.10.30.30.20.30.4-0.0
Baseline Anxiety0.00.00.10.0-0.1-0.00.0-0.1-0.10.00.00.0-0.1-0.10.2
Tail length0.31.11.4-1.2-1.1-1.1-1.1-1.1-1.1-1.0-1.0-1.0-0.7-0.9-0.9
Length with tail0.31.42.0-1.3-1.2-1.2-1.2-1.1-1.1-1.2-1.1-1.3-1.4-1.2-0.9
Length without tail0.51.74.7-1.1-0.9-1.2-1.3-0.9-0.9-1.3-1.1-1.7-2.2-1.6-0.7
Times rat made contact with spout0.10.10.30.00.0-0.1-0.00.20.2-0.1-0.2-0.2-0.5-0.40.5
Lifetime Intake2.22.73.2-1.8-1.7-1.8-1.7-1.7-1.7-1.7-1.7-1.5-1.3-1.4-1.6
Liver weight, left1.83.03.9-1.9-2.0-1.8-1.7-1.9-1.9-1.7-1.6-1.3-1.5-1.5-1.8
Liver weight, right1.32.33.4-1.6-1.5-1.6-1.5-1.3-1.3-1.6-1.6-1.7-1.8-1.6-1.0
Locomotor activity1.93.04.3-2.0-2.0-1.6-1.7-2.0-2.0-1.6-1.6-1.4-1.2-1.3-2.1
Locomotor testing distance1.12.04.5-1.5-1.6-1.3-1.3-1.6-1.6-1.2-1.3-1.1-0.8-1.0-2.1
Locomotor testing rearing4.18.310.2-2.9-2.9-2.9-2.9-3.0-3.0-2.9-2.9-2.8-2.5-2.7-3.2
Locomotion in novel chamber0.10.20.40.40.40.50.40.30.30.40.40.40.60.5-0.1
Locomotion in novel chamber post-restriction0.81.21.51.11.11.11.21.21.21.21.21.21.11.10.3
Fecal boli incidents, locomotor time 10.00.00.1-0.1-0.2-0.1-0.1-0.2-0.2-0.1-0.1-0.1-0.3-0.1-0.3
Change in fecal boli incidents, locomotor task0.80.81.10.90.90.80.90.90.90.91.00.81.01.00.9
Time >=10cm from walls, locomotor time 10.00.00.1-0.10.0-0.1-0.10.10.1-0.2-0.3-0.2-0.0-0.20.4
Bouts of movement, locomotor time 12.02.32.71.51.61.61.51.71.71.51.51.31.31.51.3
Total resting periods, locomotor time 12.73.03.51.71.91.81.81.91.91.71.81.51.61.81.5
Rest time, locomotor task time 10.20.20.40.40.40.40.40.50.50.40.40.30.40.50.6
Distance moved, locomotor task time 10.30.50.7-0.5-0.8-0.7-0.6-0.8-0.8-0.6-0.6-0.3-0.7-0.8-0.8
Vertical activity count, locomotor time 10.00.00.20.3-0.00.10.20.00.00.20.20.5-0.1-0.0-0.0
Time >=10cm from walls, locomotor time 20.10.10.30.50.30.10.30.20.20.30.30.60.40.3-0.2
Bouts of movement, locomotor time 23.76.08.12.72.82.62.52.72.72.42.42.01.82.22.1
Total resting periods, locomotor time 23.05.27.02.52.62.52.42.52.52.32.31.91.62.01.9
Rest time, locomotor task time 20.00.00.1-0.0-0.10.20.20.30.30.20.00.00.10.10.2
Distance moved, locomotor task time 20.70.81.3-0.7-0.9-1.0-0.9-1.0-1.0-0.9-0.8-0.6-1.0-0.9-1.1
Vertical activity count, locomotor time 20.10.10.40.60.50.30.40.20.20.40.50.5-0.10.3-0.0
Light reinforcement 10.10.20.5-0.4-0.4-0.5-0.5-0.3-0.3-0.5-0.7-0.5-0.6-0.5-0.1
Light reinforcement 20.10.10.3-0.3-0.2-0.2-0.3-0.3-0.3-0.3-0.5-0.4-0.6-0.3-0.5
Bone: marrow area0.00.00.10.20.30.10.10.10.10.10.10.0-0.1-0.10.4
Bone: maximum diameter2.13.94.4-2.1-1.8-1.9-2.0-2.1-2.1-2.0-1.9-2.1-1.9-2.0-1.6
Bone: maximum force0.20.30.4-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.4
Bone: maximum moment0.20.40.5-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.6-0.6-0.5-0.6-0.6
Mean time between licks in bursts0.00.10.20.30.20.10.30.30.30.30.30.50.40.30.2
Mean num. licks in bursts1.82.74.71.71.61.61.82.22.21.61.31.51.11.21.8
Cd content in liver0.10.10.30.20.30.00.00.30.3-0.1-0.1-0.3-0.4-0.30.5
Co content in liver1.41.62.31.41.21.31.31.21.21.21.31.31.11.01.5
Cu content in liver0.20.30.5-0.6-0.5-0.5-0.6-0.7-0.7-0.5-0.3-0.6-0.3-0.5-0.3
Fe content in liver4.15.06.5-2.5-2.2-2.2-2.4-2.5-2.5-2.2-2.0-2.4-2.2-2.0-1.6
K content in liver0.10.10.2-0.3-0.3-0.1-0.2-0.5-0.5-0.10.1-0.0-0.0-0.1-0.2
Mg content in liver0.30.30.7-0.6-0.8-0.6-0.6-0.8-0.8-0.5-0.4-0.2-0.1-0.5-0.6
Mn content in liver0.91.02.0-0.9-1.4-1.0-0.9-1.0-1.0-1.0-1.0-0.4-0.8-1.1-1.1
Na content in liver0.10.10.4-0.4-0.4-0.3-0.4-0.6-0.6-0.3-0.2-0.1-0.4-0.20.2
Rb content in liver0.20.20.4-0.4-0.3-0.4-0.4-0.3-0.3-0.5-0.4-0.6-0.4-0.60.4
Se content in liver3.13.65.1-2.0-2.2-1.9-1.9-2.2-2.2-1.8-1.8-1.5-1.4-1.6-2.3
Sr content in liver0.00.00.0-0.1-0.20.0-0.0-0.2-0.20.0-0.10.20.10.1-0.2
Zn content in liver0.70.81.2-0.8-0.8-0.9-0.9-1.0-1.0-0.9-0.8-0.9-1.0-1.1-0.4
Bone: minimum diameter0.20.40.4-0.6-0.6-0.7-0.6-0.6-0.6-0.6-0.6-0.7-0.6-0.6-0.5
Time in familiar zone, hab. session 10.20.20.7-0.4-0.3-0.3-0.4-0.5-0.5-0.4-0.4-0.4-0.8-0.5-0.2
Time in novel zone, hab. session 10.50.50.9-0.7-0.7-0.9-0.8-0.8-0.8-0.8-0.8-0.6-0.4-0.6-0.5
Total zone transitions, hab. session 10.30.41.5-0.6-0.5-0.7-0.6-0.4-0.4-0.6-0.7-0.7-1.2-0.7-0.2
Total locomotion distance, hab. session 10.30.50.60.70.70.60.70.70.70.80.80.70.20.70.8
Locomotion velocity, hab. session 11.11.51.81.31.31.21.31.31.31.31.31.20.81.21.1
Time in familiar zone, hab. session 20.20.20.7-0.4-0.3-0.5-0.5-0.5-0.5-0.4-0.3-0.6-0.4-0.3-0.9
Time in novel zone, hab. session 20.10.10.50.20.20.10.10.20.20.00.00.20.10.10.7
Total zone transitions, hab. session 20.50.61.0-0.6-0.9-0.8-0.8-0.8-0.8-0.7-0.7-0.6-1.0-0.9-0.9
Total locomotion distance, hab. session 20.50.71.01.00.80.90.90.80.80.91.00.90.40.70.6
Locomotion velocity, hab. session 20.30.40.60.80.60.70.70.70.70.70.80.70.10.50.4
Novel to familiar place preference ratio1.01.11.7-1.1-1.0-1.1-1.0-0.7-0.7-1.2-1.3-1.3-0.9-1.2-0.6
Novelty place preference0.90.91.5-1.0-0.9-1.0-1.0-0.7-0.7-1.1-1.2-1.2-0.8-1.1-0.6
Time in novel zone, NPP test1.11.11.8-1.1-1.0-1.2-1.1-0.8-0.8-1.2-1.4-1.2-0.9-1.2-0.7
Total zone transitions, NPP test0.10.20.7-0.4-0.4-0.3-0.4-0.4-0.4-0.4-0.3-0.5-0.8-0.5-0.3
Total locomotion distance, NPP test0.20.21.0-0.4-0.2-0.3-0.4-0.4-0.4-0.4-0.3-0.6-1.0-0.5-0.4
Locomotion velocity, NPP test0.10.20.9-0.4-0.2-0.2-0.3-0.3-0.3-0.3-0.3-0.6-1.0-0.5-0.4
Intraocular pressure0.10.10.30.20.3-0.1-0.10.10.1-0.10.0-0.3-0.5-0.20.6
Delta distance traveled before/after self-admin2.02.12.91.41.41.41.51.41.41.51.31.51.71.51.4
Delta ambulatory time before/after self-admin0.40.61.00.60.60.70.70.70.70.70.60.91.00.90.7
Parametrial fat weight0.10.10.2-0.3-0.4-0.4-0.3-0.4-0.4-0.3-0.4-0.1-0.2-0.4-0.5
Pavlov. Cond. lever latency0.50.61.20.80.80.60.70.70.70.80.70.81.11.00.7
Pavlov. Cond. magazine entry latency0.10.20.7-0.2-0.1-0.3-0.3-0.2-0.2-0.4-0.3-0.6-0.8-0.5-0.2
Pavlov. Cond. change in total contacts0.50.50.80.90.80.70.80.90.90.70.70.60.50.40.5
Pavlov. Cond. index score0.30.41.1-0.4-0.5-0.5-0.5-0.5-0.5-0.6-0.5-0.6-1.0-0.8-0.6
Pavlov. Cond. latency score0.10.10.4-0.1-0.2-0.1-0.2-0.2-0.2-0.2-0.1-0.3-0.6-0.4-0.3
Pavlov. Cond. lever contacts0.30.40.9-0.6-0.6-0.4-0.5-0.5-0.5-0.6-0.5-0.7-1.0-0.8-0.5
Pavlov. Cond. magazine entry number0.10.10.4-0.1-0.10.10.1-0.0-0.00.20.10.40.60.40.1
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.3-0.5-0.4-0.3-0.3-0.3-0.4-0.4-0.10.1-0.3-0.6
Pavlov. Cond. lever-magazine prob. diff.0.30.41.1-0.4-0.6-0.5-0.5-0.5-0.5-0.6-0.5-0.6-1.0-0.8-0.8
Pavlov. Cond. response bias1.01.22.6-0.9-0.9-1.0-1.0-0.9-0.9-1.1-1.0-1.3-1.6-1.3-0.9
Pavlov. Cond. lever latency0.00.10.50.00.00.20.20.10.10.20.10.20.30.20.7
Pavlov. Cond. magazine entry latency0.30.31.3-0.10.1-0.5-0.4-0.0-0.0-0.6-0.6-0.9-1.1-0.8-0.0
Pavlov. Cond. change in total contacts0.10.10.30.50.60.10.30.50.50.20.20.1-0.20.10.2
Pavlov. Cond. index score0.10.10.30.20.3-0.2-0.10.20.2-0.2-0.2-0.4-0.5-0.3-0.2
Pavlov. Cond. latency score0.00.10.20.30.4-0.10.10.30.3-0.1-0.0-0.2-0.3-0.1-0.1
Pavlov. Cond. lever contacts0.10.20.6-0.2-0.2-0.4-0.4-0.3-0.3-0.4-0.3-0.5-0.5-0.4-0.8
Pavlov. Cond. magazine entry number0.20.20.9-0.7-0.9-0.2-0.3-0.7-0.7-0.2-0.30.20.4-0.1-0.4
Pavlov. Cond. intertrial magazine entries0.00.10.2-0.2-0.30.10.1-0.1-0.10.20.10.30.30.20.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.5-0.00.1-0.4-0.30.00.0-0.4-0.3-0.5-0.7-0.5-0.3
Pavlov. Cond. response bias0.00.10.30.10.2-0.2-0.10.10.1-0.2-0.1-0.3-0.5-0.3-0.3
Time in closed arm before self-admin0.91.11.3-1.1-1.0-1.1-1.1-1.0-1.0-1.1-1.0-1.2-1.0-1.0-1.0
Time in closed arm after self-admin0.70.71.10.81.10.80.70.90.90.80.90.51.01.00.3
Time in open arm before self-admin1.01.01.51.11.01.01.00.90.91.01.01.21.01.01.0
Time in open arm after self-admin0.20.20.70.50.10.50.50.30.30.50.30.90.40.30.7
Bone: periosteal estimation0.30.60.7-0.8-0.6-0.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.5
Bone: periosteal perimeter0.20.40.6-0.7-0.5-0.6-0.7-0.7-0.7-0.6-0.6-0.8-0.5-0.6-0.4
Bone: post-yield work0.71.01.50.91.00.80.91.11.10.90.90.71.21.11.0
Progressive ratio test 1 active lever presses2.43.04.5-1.9-2.1-1.8-1.7-1.8-1.8-1.7-1.7-1.4-1.1-1.4-2.1
Progressive ratio test 1 breakpoint2.12.64.0-1.8-2.0-1.7-1.6-1.7-1.7-1.6-1.6-1.2-0.9-1.3-2.0
Progressive ratio test 1 inactive lever presses1.31.92.3-1.4-1.3-1.4-1.4-1.4-1.4-1.4-1.4-1.3-1.3-1.2-1.5
Progressive ratio test 2 active lever presses1.92.32.8-1.6-1.5-1.6-1.6-1.7-1.7-1.5-1.5-1.5-1.3-1.3-1.3
Progressive ratio test 2 breakpoint2.22.63.1-1.7-1.6-1.7-1.7-1.7-1.7-1.6-1.6-1.6-1.4-1.4-1.4
Progressive ratio test 2 inactive lever presses0.10.20.3-0.4-0.3-0.4-0.4-0.5-0.5-0.4-0.3-0.4-0.3-0.2-0.5
Incentive Sensitization - Responses1.11.52.2-1.2-0.9-1.2-1.3-1.3-1.3-1.3-1.2-1.5-1.4-1.2-0.7
Incentive Sensitization - Breakpoint1.01.32.0-1.1-0.8-1.1-1.2-1.2-1.2-1.2-1.1-1.4-1.4-1.2-0.7
Sum of active levers in priming session hrs 5-60.30.30.70.50.40.50.60.50.50.60.50.80.70.60.1
Progressive ratio1.21.93.11.31.51.51.31.31.31.41.31.11.71.51.1
Food seeking constrained by brief footshock4.96.07.42.52.32.32.62.52.52.52.42.72.42.42.1
Seeking ratio, punishment vs. effort0.40.61.10.80.60.60.90.90.90.80.71.00.40.60.6
Retroperitoneal fat weight0.00.10.3-0.3-0.0-0.1-0.3-0.3-0.3-0.3-0.3-0.5-0.5-0.30.1
Reaction time number correct4.07.79.1-2.9-2.9-3.0-2.8-2.7-2.7-2.8-2.8-2.5-2.6-2.5-2.8
Reaction time mean minus median0.00.00.20.30.40.20.20.30.30.10.2-0.00.10.0-0.1
Reaction time mean minus median AUC0.10.30.7-0.4-0.2-0.5-0.6-0.4-0.4-0.6-0.6-0.8-0.5-0.7-0.8
Reaction time num false alarms4.26.07.2-2.4-2.2-2.5-2.5-2.4-2.4-2.5-2.5-2.6-2.7-2.6-2.0
Reaction time num false alarms AUC3.25.05.9-2.2-2.0-2.3-2.3-2.2-2.2-2.3-2.2-2.3-2.4-2.3-2.0
Reaction time trials correct on left4.07.79.1-2.9-2.9-3.0-2.8-2.7-2.7-2.8-2.8-2.5-2.6-2.5-2.8
Reaction time trials on left4.17.79.1-2.9-2.9-3.0-2.8-2.7-2.7-2.8-2.8-2.5-2.6-2.5-2.8
Reaction time mean0.81.32.01.41.41.21.21.31.31.00.90.90.90.81.0
Reaction time mean AUC0.60.91.41.21.21.01.01.11.10.90.80.70.70.60.7
Median of all reaction times1.21.72.51.61.51.31.31.51.51.21.11.11.01.01.3
Reaction time omissions0.00.00.2-0.0-0.1-0.1-0.20.00.0-0.3-0.3-0.2-0.3-0.40.0
Reaction time false alarm rate0.10.10.3-0.2-0.1-0.2-0.4-0.4-0.4-0.4-0.3-0.6-0.6-0.5-0.1
Reaction time premature initiation rate0.40.50.70.80.70.80.80.90.90.70.70.70.50.50.4
Reaction time premature initiations0.30.51.2-0.7-0.8-0.7-0.7-0.6-0.6-0.7-0.7-0.6-0.8-0.8-1.1
Std. dev. reaction times0.10.20.40.60.60.50.40.50.50.40.40.30.50.3-0.1
Reaction time trials completed4.17.79.1-2.9-2.9-3.0-2.8-2.7-2.7-2.8-2.8-2.5-2.6-2.5-2.8
Reaction time trials AUC4.99.311.0-3.1-3.2-3.3-3.1-3.0-3.0-3.1-3.1-2.8-2.9-2.8-3.1
Run reversals in cocaine runway, females0.30.30.60.50.60.60.50.50.50.50.50.30.80.60.2
Run reversals in cocaine runway, males0.50.51.1-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.6-1.1-0.9-0.1
Latency to leave start box in cocaine runway0.20.20.5-0.6-0.3-0.4-0.5-0.3-0.3-0.5-0.5-0.7-0.5-0.4-0.4
Latency to leave start box in cocaine runway, F0.80.91.2-1.1-1.0-0.9-1.0-1.0-1.0-0.9-1.0-1.0-0.6-0.8-1.1
Latency to leave start box in cocaine runway, M0.10.10.20.10.40.20.10.40.40.10.1-0.3-0.30.00.4
Std. dev. time between licks in bursts0.00.10.2-0.2-0.3-0.2-0.10.00.0-0.2-0.3-0.3-0.5-0.3-0.2
Total sessions with >9 infusions3.54.25.5-2.2-2.3-2.2-2.1-2.1-2.1-2.1-2.1-1.8-1.3-1.7-2.2
Short access day 1 total inactive lever presses0.50.61.0-0.7-0.6-0.7-0.8-0.8-0.8-0.8-0.7-0.9-1.0-0.8-0.7
Short access day 10 total inactive lever presses0.51.32.01.31.41.21.21.11.11.11.20.90.70.91.2
Short access day 1 total infusions1.72.23.1-1.6-1.8-1.6-1.5-1.6-1.6-1.5-1.6-1.3-0.9-1.2-1.4
Short access day 10 total infusions3.44.35.5-2.3-2.3-2.3-2.1-2.1-2.1-2.1-2.2-1.8-1.6-1.8-2.1
Short access total infusions1.92.53.3-1.7-1.8-1.7-1.6-1.7-1.7-1.6-1.7-1.3-1.1-1.3-1.6
Short access day 1 locomotion2.93.64.6-2.0-2.1-2.1-2.0-2.0-2.0-2.0-2.1-1.7-1.3-1.7-1.8
Short access day 10 total locomotion0.00.10.30.1-0.2-0.3-0.1-0.0-0.0-0.2-0.3-0.0-0.5-0.4-0.2
Short access total locomotion0.81.01.9-0.9-1.3-1.1-0.9-0.9-0.9-1.0-1.1-0.5-0.6-0.8-1.4
One hour access (0.3 mA shock)0.10.10.2-0.3-0.1-0.3-0.3-0.2-0.2-0.3-0.2-0.4-0.4-0.2-0.4
Compulsive drug intake0.40.51.3-0.6-0.7-0.6-0.6-0.5-0.5-0.6-0.6-0.7-0.9-0.9-1.1
One hour access (shock baseline)0.81.21.4-1.2-1.0-1.2-1.2-1.1-1.1-1.2-1.2-1.1-1.1-0.9-0.8
Social response proportion1.51.73.2-1.2-1.1-1.4-1.2-1.0-1.0-1.4-1.4-1.5-1.8-1.5-0.9
Social responses0.91.21.5-1.1-1.0-1.1-1.1-1.0-1.0-1.1-1.2-1.2-1.2-1.2-1.0
Social time3.04.14.82.12.12.12.12.12.12.12.11.82.22.01.5
Soleus weight0.20.51.3-0.8-0.3-0.5-0.7-0.6-0.6-0.6-0.6-1.2-1.1-0.70.0
Bone: stiffness0.81.31.6-1.2-1.0-1.1-1.2-1.2-1.2-1.1-1.0-1.2-1.3-1.0-1.1
Tibialis anterior weight3.311.313.7-3.6-3.1-3.2-3.4-3.4-3.4-3.4-3.4-3.7-3.6-3.4-2.6
Time to tail flick, vehicle, before self-admin2.82.94.2-1.7-2.0-1.8-1.6-1.8-1.8-1.6-1.8-1.2-1.2-1.6-2.1
Time to tail flick, vehicle, after self-admin0.00.00.2-0.20.1-0.1-0.2-0.2-0.2-0.2-0.1-0.5-0.10.00.0
Time to tail flick, test, before self-admin0.50.51.10.80.40.70.80.70.70.80.61.10.70.60.5
Time to tail flick, test, after self-admin0.30.30.80.40.40.40.50.40.40.50.50.60.90.70.6
Delta time to tail flick, vehicle, before/after SA0.10.10.30.30.50.30.20.30.30.30.40.00.10.30.5
Delta time to tail flick, test, before/after SA0.80.81.2-1.1-0.8-1.0-1.0-1.0-1.0-0.9-0.9-1.0-0.6-0.7-0.5
Tibia length0.20.61.6-0.7-0.8-0.9-0.8-0.6-0.6-0.8-0.8-0.8-1.3-1.0-0.3
Ambulatory time before self-admin0.00.00.00.00.10.10.00.00.00.00.1-0.10.0-0.10.1
Ambulatory time after self-admin0.50.51.10.60.60.70.70.70.70.70.70.71.00.80.6
Bone: tissue strength0.80.81.51.00.80.80.90.90.90.80.81.01.20.80.4
Total heroin consumption0.00.00.00.20.10.10.10.10.10.10.10.1-0.10.0-0.1
Bone: trabecular number0.00.10.20.10.20.20.20.40.40.10.0-0.1-0.3-0.00.3
Bone: trabecular spacing0.00.00.1-0.1-0.1-0.1-0.2-0.3-0.3-0.10.0-0.00.3-0.1-0.1
Bone: trabecular thickness1.51.92.5-1.4-1.4-1.4-1.4-1.2-1.2-1.4-1.5-1.5-1.6-1.5-1.0
Bone: trabecular tissue density0.30.50.7-0.6-0.6-0.7-0.7-0.6-0.6-0.7-0.7-0.8-0.7-0.7-0.6
Water consumed over 24 hours0.10.20.90.40.10.10.30.50.50.20.00.3-0.4-0.21.0
Number of responses in last shaping day2.72.93.4-1.8-1.8-1.8-1.9-1.8-1.8-1.8-1.8-1.7-1.4-1.6-1.4