Hub : Genes

Zfand2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Zfand2b	0.02	0.02	3.8e-03	0.01	0.02	0.01	0.02	8.5e-03	2.8e-03	8.0e-03	4.9e-03
2	pVTA	gene expression	Zfand2b	0.07	0.06	1.8e-05	0.04	0.05	0.05	0.04	5.2e-04	3.6e-05	1.4e-04	1.4e-04
3	PL	intron excision ratio	chr9_84116547_84116848	0.02	0.02	8.9e-03	0.02	0.02	0.02	0.02	6.0e-03	6.7e-03	6.9e-03	5.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.0	0.1	0.1	0.1	-0.3
Area under the delay curve	1.6	2.5	2.8	1.7	1.7	-1.4
BMI with tail	0.0	0.1	0.1	0.3	0.3	-0.4
BMI without tail	0.6	3.3	3.4	-1.8	-1.8	1.8
Body weight	1.1	4.6	4.7	-2.2	-2.2	2.1
Weight adjusted by age	0.5	1.4	1.7	1.1	1.1	-1.3
Bone surface	0.2	0.3	0.7	0.4	0.4	-0.8
Bone volume	0.0	0.0	0.1	-0.0	-0.0	-0.3
Breakpoint value in progressive ratio session	0.2	0.4	0.5	0.7	0.7	-0.7
Number of licking bursts	0.0	0.1	0.2	-0.4	-0.5	0.1
Context. condit. distance diff. score	0.5	0.6	0.6	-0.8	-0.8	0.8
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	-0.3	0.2
Locomotion distance, session 1	0.0	0.0	0.0	0.1	0.1	-0.1
Locomotion velocity, session 2	1.1	1.3	1.5	1.1	1.1	-1.2
Locomotion distance, session 2	3.6	5.0	5.2	2.2	2.2	-2.3
Locomotion velocity, session 3	1.8	2.0	2.1	1.4	1.4	-1.5
Locomotion distance, session 3	0.0	0.0	0.0	0.0	0.0	0.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	-0.2	-0.2	0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	-0.3	0.4
Locomotion velocity, session 7	0.3	0.3	0.3	0.5	0.5	-0.6
Locomotion distance, session 7	0.2	0.2	0.2	0.4	0.4	-0.5
Stereotopy head waving bouts, day 7	0.3	0.4	0.4	0.7	0.7	-0.6
Stereotopy head waving duration, day 7	0.4	0.5	0.5	0.7	0.7	-0.6
Locomotion velocity, session 8	1.7	2.0	2.1	1.4	1.4	-1.5
Locomotion distance, session 8	0.3	0.4	0.4	0.6	0.6	-0.7
Degree of sensitization distance	0.0	0.0	0.0	0.1	0.1	-0.2
Degree of sensitization stereotypy	0.8	0.9	1.0	1.0	1.0	-0.9
Conditioned locomotion	0.3	0.4	0.4	-0.6	-0.6	0.7
Cocaine response after cond. corrected	5.8	8.7	9.2	-3.0	-3.0	2.7
Cocaine response after cond. not corrected	5.8	8.4	8.9	-3.0	-3.0	2.7
Cocaine response before conditioning	0.1	0.2	0.2	0.4	0.4	-0.4
Saline control response	1.9	2.6	2.7	1.6	1.6	-1.6
Bone: connectivity density	0.0	0.0	0.0	-0.2	-0.2	-0.1
Bone: cortical apparent density	0.1	0.1	0.1	0.4	0.4	-0.1
Bone: cortical area	0.1	0.1	0.2	0.3	0.3	-0.4
Bone: cortical porosity	0.2	0.2	0.3	0.5	0.5	-0.4
Bone: cortical porosity	0.0	0.0	0.1	0.2	0.2	-0.2
Bone: cortical thickness	0.0	0.0	0.0	0.0	0.0	0.1
Bone: cortical thickness	0.1	0.1	0.1	0.2	0.3	-0.2
Bone: cortical tissue density	0.0	0.1	0.1	0.3	0.3	-0.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.0	-0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	-0.6	-0.7	0.7
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	0.1	-0.3
Condit. Reinf. inactive responses	0.2	0.3	0.4	0.5	0.5	-0.7
Incentive salience index mean	0.0	0.0	0.1	0.1	0.1	-0.2
Condit. Reinf. lever presses	0.2	0.3	0.3	-0.6	-0.6	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.4	-0.4	0.7
Condit. Reinf. active-inactive response ratio	0.5	0.8	1.2	-0.8	-0.8	1.1
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	0.2	-0.1
Condit. Reinf. inactive responses	1.8	2.7	3.3	1.6	1.6	-1.8
Condit. Reinf. lever presses	0.2	0.3	0.4	0.6	0.6	-0.4
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.4	0.4	-0.2
Conditioned reinforcement - actives	0.2	0.7	0.8	0.9	0.8	-0.8
Conditioned reinforcement - inactives	0.0	0.1	0.3	-0.1	-0.2	0.6
Conditioned locomotion	2.0	2.9	3.3	1.8	1.8	-1.5
Patch foraging indifference point 0 sec	3.9	11.0	12.6	3.6	3.4	-2.9
Patch foraging indifference point AUC	0.0	0.0	0.0	-0.0	0.1	-0.2
Delay disc. indifference point, 0s delay	0.8	0.9	1.0	0.9	0.9	-1.0
Delay disc. indifference point, 16s delay	0.3	0.5	0.6	0.7	0.7	-0.5
Delay disc. indifference point, 2s delay	4.3	4.7	4.8	2.2	2.2	-2.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.0	-0.0	0.3
Delay disc. indifference point, 4s delay	1.6	1.7	1.8	1.3	1.3	-1.3
Delay disc. indifference point, 8s delay	1.8	3.0	3.4	1.8	1.8	-1.5
Indifference point function ln k	0.2	0.5	0.6	0.7	0.6	-0.8
Indifference point function log k	0.2	0.5	0.6	0.7	0.6	-0.8
Patch foraging total patch changes 0 sec	3.3	9.7	11.4	3.4	3.3	-2.7
Patch foraging total patch changes 12 sec	3.8	5.1	5.5	2.3	2.3	-2.1
Patch foraging total patch changes 18 sec	1.5	3.5	4.4	2.1	2.0	-1.5
Patch foraging total patch changes 24 sec	0.9	3.1	3.9	2.0	1.9	-1.4
Patch foraging total patch changes 6 sec	2.0	3.4	4.1	2.0	2.0	-1.4
Patch foraging time to switch 0 sec	0.2	0.7	0.9	-0.7	-0.8	0.9
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.2	0.2	-0.1
Patch foraging water rate 12 sec	0.2	0.9	1.1	1.0	1.0	-0.8
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.1	-0.1	0.3
Patch foraging water rate 24 sec	0.8	1.1	1.3	1.2	1.1	-0.8
Patch foraging water rate 6 sec	0.6	0.9	1.1	0.9	0.9	-1.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	-0.1	-0.1	-0.4
Distance traveled before self-admin	0.0	0.0	0.0	-0.2	-0.2	-0.1
Distance traveled after self-admin	1.7	3.0	3.2	1.7	1.7	-1.8
Extensor digitorum longus weight	0.2	0.6	1.0	0.6	0.7	-1.0
Bone: elastic displacement	2.8	3.5	3.8	1.9	1.9	-1.7
Bone: elastic work	0.8	1.0	1.1	1.0	1.0	-0.9
Bone: endosteal estimation	1.3	3.2	4.2	1.6	1.7	-2.0
Bone: endosteal perimeter	0.2	0.4	0.5	-0.7	-0.7	0.3
Epididymis fat weight	0.3	1.3	1.4	-1.1	-1.2	1.2
Delta time in closed arm before/after self-admin	1.3	1.2	1.4	1.2	1.1	-1.0
Delta time in open arm before/after self-admin	3.1	3.7	3.7	-1.9	-1.9	1.9
Diff in mean of infusions in LGA sessions	0.6	1.1	1.3	1.1	1.1	-0.9
Delay discount exponential model param	1.6	2.2	2.4	-1.5	-1.5	1.3
Extinction: sum of active levers before priming	0.1	0.2	0.4	0.3	0.3	-0.6
Active lever presses in extinction session 6	1.0	1.0	1.4	0.9	0.9	-1.2
Bone: final force	1.3	2.1	2.3	1.4	1.4	-1.5
Bone: final moment	1.8	2.8	3.0	1.7	1.7	-1.7
Food consumed during 24 hour testing period	0.0	0.0	0.0	0.1	0.1	-0.1
Glucose	0.0	0.0	0.0	-0.1	-0.1	0.1
Heart weight	0.9	1.5	1.6	1.2	1.2	-1.3
Delay discount hyperbolic model param	2.3	3.0	3.2	-1.8	-1.8	1.6
Intermittent access intake day 1-15 change	0.3	1.8	2.2	1.5	1.3	-1.2
Intermittent access intake escalation	0.3	1.8	2.2	1.5	1.3	-1.2
Intermittent access intake escalation 2	1.1	1.8	2.0	1.4	1.3	-1.4
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	-0.4	-0.5	0.0
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.5	-0.7	-0.9	1.2
Intermitt. access escalation Index	0.2	0.6	0.8	-0.9	-0.8	0.7
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	-0.1	0.0
Intermittent access day 15 total infusions	0.2	0.5	0.7	0.8	0.7	-0.6
Intermittent access terminal intake (last 3 days)	0.4	0.6	0.7	0.8	0.8	-0.7
Intermittent access total infusions	0.0	0.0	0.0	0.1	0.1	-0.1
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.1	0.2	-0.2
Intermittent access day 15 total locomotion	0.5	1.8	2.4	1.5	1.4	-1.0
Intermittent access total locomotion	0.8	1.0	1.1	1.1	1.0	-0.9
Intermittent access standard deviation	0.2	1.0	1.5	1.2	1.1	-0.7
Left kidney weight	0.0	0.2	0.3	-0.5	-0.4	0.4
Right kidney weight	0.2	1.5	1.7	-1.3	-1.2	1.2
Cocaine induced anxiety	0.1	0.3	0.6	0.4	0.5	-0.8
Post-drug Anxiety	0.4	0.5	1.0	0.4	0.5	-1.0
Baseline Anxiety	0.3	0.4	0.5	0.7	0.7	-0.6
Tail length	1.7	9.2	9.4	-3.0	-3.0	3.1
Length with tail	1.9	8.5	8.6	-2.9	-2.9	2.9
Length without tail	0.2	1.0	1.0	-1.0	-1.0	1.0
Times rat made contact with spout	0.0	0.0	0.0	0.2	0.1	0.1
Lifetime Intake	0.0	0.0	0.0	0.1	0.1	-0.2
Liver weight, left	0.0	0.0	0.0	-0.1	-0.1	0.1
Liver weight, right	0.8	1.4	1.4	-1.2	-1.2	1.2
Locomotor activity	1.2	1.9	2.1	1.3	1.3	-1.4
Locomotor testing distance	1.9	4.7	4.9	2.1	2.2	-2.2
Locomotor testing rearing	2.4	8.9	9.2	3.0	3.0	-2.9
Locomotion in novel chamber	0.2	0.2	0.4	0.4	0.4	-0.6
Locomotion in novel chamber post-restriction	0.1	0.4	0.6	-0.6	-0.5	0.8
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.4	-0.4	0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.5	0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.9	1.1	1.2	1.0	1.0	-1.1
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.2	-0.2	0.0
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.2	0.2	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	0.2	-0.4
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	0.3	0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.1	0.1	0.4
Time >=10cm from walls, locomotor time 2	0.2	0.7	1.3	0.6	0.6	-1.1
Bouts of movement, locomotor time 2	0.0	0.1	0.3	0.2	0.2	-0.5
Total resting periods, locomotor time 2	0.0	0.2	0.3	0.3	0.2	-0.6
Rest time, locomotor task time 2	0.5	0.9	1.1	1.1	1.0	-0.7
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	-0.0	0.1
Vertical activity count, locomotor time 2	0.4	1.0	1.6	-0.9	-0.8	1.3
Light reinforcement 1	1.0	4.6	5.4	2.3	2.3	-1.7
Light reinforcement 2	0.7	1.7	2.0	1.4	1.4	-1.1
Bone: marrow area	1.3	3.2	4.3	1.6	1.7	-2.1
Bone: maximum diameter	0.2	0.4	0.5	-0.7	-0.7	0.5
Bone: maximum force	1.9	3.7	4.5	1.8	1.8	-2.1
Bone: maximum moment	2.5	4.7	5.5	2.1	2.1	-2.3
Mean time between licks in bursts	0.8	5.1	6.8	2.1	2.0	-2.6
Mean num. licks in bursts	0.3	0.9	1.2	1.1	1.1	-0.7
Cd content in liver	0.0	0.0	0.0	0.2	0.2	-0.2
Co content in liver	1.0	1.2	1.3	1.1	1.1	-1.0
Cu content in liver	0.2	0.2	0.2	-0.4	-0.4	0.4
Fe content in liver	0.4	0.5	0.6	0.7	0.7	-0.7
K content in liver	0.3	0.3	0.4	-0.6	-0.6	0.6
Mg content in liver	0.1	0.2	0.3	-0.3	-0.3	0.5
Mn content in liver	0.1	0.1	0.1	0.2	0.2	-0.3
Na content in liver	0.0	0.0	0.0	0.0	0.0	0.1
Rb content in liver	1.1	1.3	1.3	-1.1	-1.1	1.2
Se content in liver	2.1	2.5	2.5	-1.6	-1.6	1.6
Sr content in liver	0.2	0.1	0.1	0.4	0.4	-0.4
Zn content in liver	0.5	0.6	0.8	-0.7	-0.7	0.9
Bone: minimum diameter	0.7	1.4	1.7	1.1	1.1	-1.3
Time in familiar zone, hab. session 1	3.3	3.6	3.8	-2.0	-2.0	1.8
Time in novel zone, hab. session 1	1.4	1.6	1.8	1.3	1.3	-1.1
Total zone transitions, hab. session 1	0.2	0.3	0.3	0.6	0.6	-0.5
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.3	0.3	-0.3
Locomotion velocity, hab. session 1	0.1	0.2	0.2	0.5	0.5	-0.4
Time in familiar zone, hab. session 2	2.0	2.3	2.5	-1.6	-1.6	1.4
Time in novel zone, hab. session 2	2.8	3.1	3.3	1.8	1.8	-1.6
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.1	-0.1	0.1
Total locomotion distance, hab. session 2	0.0	0.0	0.0	-0.0	-0.0	0.0
Locomotion velocity, hab. session 2	0.1	0.2	0.2	-0.4	-0.4	0.4
Novel to familiar place preference ratio	0.5	0.6	0.8	-0.9	-0.9	0.6
Novelty place preference	0.2	0.2	0.3	-0.5	-0.5	0.3
Time in novel zone, NPP test	0.0	0.1	0.1	-0.3	-0.3	0.1
Total zone transitions, NPP test	0.0	0.0	0.0	-0.0	-0.0	0.1
Total locomotion distance, NPP test	0.2	0.3	0.3	0.5	0.5	-0.5
Locomotion velocity, NPP test	0.2	0.3	0.3	0.5	0.5	-0.5
Intraocular pressure	0.9	1.5	1.7	1.3	1.3	-1.0
Delta distance traveled before/after self-admin	3.1	3.4	3.7	1.9	1.9	-1.8
Delta ambulatory time before/after self-admin	3.0	5.2	5.6	2.4	2.4	-2.1
Parametrial fat weight	1.8	4.3	4.4	-2.1	-2.1	2.0
Pavlov. Cond. lever latency	0.4	0.6	0.6	0.7	0.7	-0.8
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.2	-0.2	0.2
Pavlov. Cond. change in total contacts	0.3	0.4	0.4	-0.6	-0.6	0.6
Pavlov. Cond. index score	1.3	1.7	1.7	-1.3	-1.3	1.3
Pavlov. Cond. latency score	0.9	1.2	1.2	-1.1	-1.1	1.1
Pavlov. Cond. lever contacts	0.8	1.0	1.0	-1.0	-1.0	1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	2.3	-1.5	-1.5	1.5
Pavlov. Cond. response bias	0.6	0.7	0.7	-0.8	-0.8	0.9
Pavlov. Cond. lever latency	0.7	1.0	1.3	-1.1	-1.1	0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	0.3	-0.4
Pavlov. Cond. index score	0.4	0.7	0.8	0.9	0.8	-0.8
Pavlov. Cond. latency score	0.3	0.4	0.5	0.7	0.6	-0.6
Pavlov. Cond. lever contacts	0.9	1.3	1.6	1.2	1.2	-1.0
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.5	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.5	0.5	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.7	0.6	-0.6
Pavlov. Cond. response bias	0.8	1.2	1.4	1.2	1.1	-0.9
Time in closed arm before self-admin	1.0	1.7	2.0	-1.4	-1.3	1.1
Time in closed arm after self-admin	0.7	0.8	0.9	1.0	0.9	-0.9
Time in open arm before self-admin	1.2	1.5	1.7	1.2	1.2	-1.3
Time in open arm after self-admin	0.8	0.9	1.0	-1.0	-1.0	0.9
Bone: periosteal estimation	0.7	1.6	2.2	1.1	1.1	-1.5
Bone: periosteal perimeter	0.1	0.2	0.3	-0.5	-0.5	0.3
Bone: post-yield work	0.3	0.5	0.8	0.6	0.6	-0.9
Progressive ratio test 1 active lever presses	0.2	0.3	0.3	-0.5	-0.5	0.5
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	-0.3	-0.3	0.3
Progressive ratio test 1 inactive lever presses	0.4	0.9	1.1	-1.0	-1.0	0.8
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.4	0.4	-0.7
Progressive ratio test 2 breakpoint	0.1	0.2	0.3	0.3	0.3	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.2	0.1	-0.2
Incentive Sensitization - Responses	0.2	0.4	0.8	0.5	0.5	-0.9
Incentive Sensitization - Breakpoint	0.1	0.2	0.5	0.3	0.3	-0.7
Sum of active levers in priming session hrs 5-6	0.3	0.2	0.4	-0.6	-0.6	0.2
Progressive ratio	0.2	0.5	1.1	-0.4	-0.4	1.0
Food seeking constrained by brief footshock	1.4	1.7	2.2	1.5	1.4	-0.9
Seeking ratio, punishment vs. effort	0.9	2.0	2.5	1.3	1.3	-1.6
Retroperitoneal fat weight	2.0	9.0	9.0	-3.0	-3.0	3.0
Reaction time number correct	0.0	0.0	0.1	0.2	0.2	-0.1
Reaction time mean minus median	0.0	0.1	0.3	-0.2	-0.3	0.5
Reaction time mean minus median AUC	0.0	0.3	0.5	-0.3	-0.4	0.7
Reaction time num false alarms	0.1	0.2	0.3	-0.5	-0.4	0.5
Reaction time num false alarms AUC	0.1	0.1	0.1	-0.4	-0.3	0.4
Reaction time trials correct on left	0.0	0.0	0.1	0.2	0.2	-0.1
Reaction time trials on left	0.0	0.0	0.1	0.2	0.2	-0.1
Reaction time mean	1.4	3.2	4.2	-1.6	-1.7	2.0
Reaction time mean AUC	1.0	2.5	3.3	-1.4	-1.5	1.8
Median of all reaction times	2.5	4.0	5.1	-1.8	-1.9	2.3
Reaction time omissions	0.0	0.0	0.0	0.0	0.0	0.1
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.4	0.4
Reaction time premature initiation rate	0.0	0.1	0.1	-0.3	-0.3	0.1
Reaction time premature initiations	0.0	0.1	0.1	-0.3	-0.2	0.0
Std. dev. reaction times	0.5	1.7	2.1	-1.2	-1.3	1.5
Reaction time trials completed	0.0	0.0	0.1	0.2	0.2	-0.1
Reaction time trials AUC	0.0	0.0	0.0	0.1	0.1	0.0
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.1	-0.1	-0.3
Run reversals in cocaine runway, males	2.4	2.7	2.9	-1.7	-1.7	1.5
Latency to leave start box in cocaine runway	0.1	0.2	0.2	0.5	0.5	-0.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.2	-0.1	0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	0.9	0.9	0.9	-0.9
Std. dev. time between licks in bursts	0.6	1.1	1.3	1.0	1.0	-1.1
Total sessions with >9 infusions	0.1	0.1	0.1	0.3	0.3	-0.3
Short access day 1 total inactive lever presses	0.0	0.1	0.1	-0.3	-0.2	0.2
Short access day 10 total inactive lever presses	0.0	0.3	0.3	-0.5	-0.6	0.6
Short access day 1 total infusions	0.1	0.2	0.2	0.5	0.5	-0.3
Short access day 10 total infusions	0.1	0.1	0.1	-0.4	-0.3	0.3
Short access total infusions	0.0	0.0	0.0	0.2	0.2	-0.2
Short access day 1 locomotion	1.2	2.0	2.5	1.6	1.5	-1.0
Short access day 10 total locomotion	0.1	0.6	1.0	1.0	0.9	-0.1
Short access total locomotion	0.3	0.5	0.7	0.9	0.8	-0.4
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	0.2	-0.1
Compulsive drug intake	0.5	0.7	0.9	0.9	0.9	-0.7
One hour access (shock baseline)	0.0	0.1	0.1	-0.3	-0.4	0.3
Social response proportion	1.2	1.5	1.8	-1.3	-1.3	1.0
Social responses	0.0	0.0	0.1	-0.2	-0.2	0.0
Social time	0.0	0.0	0.1	0.2	0.2	-0.2
Soleus weight	1.3	3.8	4.0	1.9	1.9	-2.0
Bone: stiffness	0.8	1.4	1.9	1.1	1.1	-1.4
Tibialis anterior weight	0.4	1.2	1.3	1.1	1.1	-1.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.5	0.5	-0.5
Time to tail flick, vehicle, after self-admin	4.8	9.7	9.9	-3.1	-3.2	3.1
Time to tail flick, test, before self-admin	0.7	0.9	1.1	-0.9	-0.8	1.1
Time to tail flick, test, after self-admin	0.6	0.7	0.7	-0.8	-0.8	0.8
Delta time to tail flick, vehicle, before/after SA	7.6	8.2	8.5	-2.8	-2.8	2.9
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.0	-0.0	-0.3
Tibia length	0.1	0.4	0.5	-0.7	-0.7	0.5
Ambulatory time before self-admin	0.0	0.0	0.1	-0.2	-0.3	0.0
Ambulatory time after self-admin	2.4	3.9	4.0	2.0	2.0	-1.9
Bone: tissue strength	1.8	1.9	2.1	1.5	1.4	-1.2
Total heroin consumption	0.7	0.8	0.8	-0.9	-0.9	0.9
Bone: trabecular number	0.0	0.1	0.2	0.1	0.1	-0.4
Bone: trabecular spacing	0.1	0.2	0.3	0.5	0.5	-0.3
Bone: trabecular thickness	0.0	0.0	0.0	0.0	-0.0	-0.1
Bone: trabecular tissue density	0.3	0.6	0.9	0.7	0.7	-0.9
Water consumed over 24 hours	0.1	0.1	0.2	0.2	0.3	-0.4
Number of responses in last shaping day	1.1	1.5	1.6	-1.3	-1.3	1.1