Hub : Genes

Zfand2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr9_76667879_76668180	0.02	0.02	9.4e-03	0.01	0.01	0.02	0.02	7.5e-03	7.8e-03	5.7e-03	6.1e-03
2	PL	gene expression	Zfand2b	0.02	0.02	4.9e-03	0.01	0.02	0.01	0.02	8.9e-03	4.6e-03	8.0e-03	4.8e-03
3	pVTA	gene expression	Zfand2b	0.1	0.09	2.1e-04	0.08	0.07	0.07	0.07	3.0e-04	3.7e-04	7.0e-04	5.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.0	0.0	-0.0	-0.1	0.2
Area under the delay curve	12.1	12.8	33.0	5.7	1.6	-1.7
BMI with tail	2.8	9.1	27.3	5.2	-0.2	0.2
BMI without tail	17.9	37.0	110.8	-10.5	-0.3	0.2
Body weight	0.6	2.4	3.4	0.8	-1.8	1.8
Weight adjusted by age	3.7	4.1	11.2	-3.3	0.7	-0.8
Bone surface	0.1	0.2	0.3	0.5	0.3	-0.4
Bone volume	0.0	0.0	0.0	-0.1	-0.1	0.1
Breakpoint value in progressive ratio session	1.7	1.9	4.9	-2.2	0.6	-0.6
Number of licking bursts	10.9	12.8	38.2	-6.2	-0.4	0.3
Context. condit. distance diff. score	0.4	0.5	0.7	-0.3	-0.8	0.8
Locomotion velocity, session 1	0.1	0.1	0.1	-0.2	-0.3	0.3
Locomotion distance, session 1	0.1	0.1	0.2	0.4	0.1	-0.0
Locomotion velocity, session 2	0.9	1.1	1.2	0.9	1.1	-1.1
Locomotion distance, session 2	3.8	5.3	6.2	2.5	2.2	-2.2
Locomotion velocity, session 3	1.2	1.4	2.0	0.5	1.4	-1.4
Locomotion distance, session 3	0.2	0.2	0.7	-0.8	0.0	-0.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	-0.3	-0.2	0.2
Stereotopy head waving duration, day 3	0.0	0.1	0.1	-0.1	-0.3	0.3
Locomotion velocity, session 7	0.4	0.5	0.9	0.9	0.5	-0.5
Locomotion distance, session 7	0.3	0.4	0.9	0.9	0.4	-0.4
Stereotopy head waving bouts, day 7	0.3	0.3	0.4	0.4	0.6	-0.6
Stereotopy head waving duration, day 7	0.4	0.5	0.6	0.7	0.8	-0.8
Locomotion velocity, session 8	1.9	2.3	3.0	1.7	1.4	-1.4
Locomotion distance, session 8	0.6	0.9	1.8	1.3	0.7	-0.7
Degree of sensitization distance	0.4	0.4	1.0	1.0	0.1	-0.1
Degree of sensitization stereotypy	0.9	1.0	1.0	0.9	1.0	-1.0
Conditioned locomotion	0.8	1.0	2.2	1.5	-0.5	0.6
Cocaine response after cond. corrected	9.5	10.7	14.3	-3.8	-3.0	2.9
Cocaine response after cond. not corrected	8.7	9.6	11.8	-3.4	-2.9	2.9
Cocaine response before conditioning	0.4	0.5	1.1	1.1	0.4	-0.4
Saline control response	3.8	4.9	11.0	3.3	1.4	-1.3
Bone: connectivity density	0.1	0.2	0.2	-0.5	-0.4	0.4
Bone: cortical apparent density	0.3	0.4	0.7	0.8	0.5	-0.5
Bone: cortical area	0.0	0.0	0.0	-0.0	0.2	-0.2
Bone: cortical porosity	0.1	0.1	0.2	-0.0	0.4	-0.4
Bone: cortical porosity	0.0	0.0	0.0	0.0	0.2	-0.2
Bone: cortical thickness	0.0	0.0	0.0	-0.2	-0.1	0.2
Bone: cortical thickness	0.0	0.1	0.2	-0.4	-0.0	-0.0
Bone: cortical tissue density	0.3	0.4	0.7	0.8	0.5	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.2	-0.0	0.0
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	-0.8	-0.7	0.7
Condit. Reinf. active responses	0.0	0.0	0.0	-0.0	0.1	-0.1
Condit. Reinf. inactive responses	0.2	0.2	0.2	0.5	0.5	-0.5
Incentive salience index mean	0.0	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. lever presses	0.2	0.2	0.2	-0.4	-0.5	0.5
Condit. Reinf. active minus inactive responses	1.3	1.6	4.5	2.1	-0.3	0.4
Condit. Reinf. active-inactive response ratio	1.9	2.0	5.0	2.2	-0.6	0.7
Condit. Reinf. active responses	1.0	1.4	4.0	2.0	0.3	-0.2
Condit. Reinf. inactive responses	1.7	2.0	2.5	1.1	1.6	-1.6
Condit. Reinf. lever presses	2.1	2.8	7.5	2.7	0.8	-0.6
Condit. Reinf. lever reinforcers received	1.1	1.5	4.1	2.0	0.5	-0.4
Conditioned reinforcement - actives	51.3	51.3	152.6	-12.4	0.7	-0.9
Conditioned reinforcement - inactives	45.6	51.3	152.6	-12.4	-0.8	0.7
Conditioned locomotion	5.8	7.0	16.7	-4.1	1.4	-1.5
Patch foraging indifference point 0 sec	9.4	15.1	19.0	-4.4	3.7	-3.6
Patch foraging indifference point AUC	8.1	9.3	27.8	5.3	-0.0	0.1
Delay disc. indifference point, 0s delay	2.5	2.7	6.2	-2.5	1.0	-1.0
Delay disc. indifference point, 16s delay	23.4	23.7	69.9	8.4	0.8	-0.8
Delay disc. indifference point, 2s delay	2.9	3.2	4.8	-0.2	2.2	-2.2
Delay disc. indifference point, 24s delay	9.1	8.8	26.5	5.1	-0.0	-0.1
Delay disc. indifference point, 4s delay	2.1	2.2	2.8	1.7	1.4	-1.4
Delay disc. indifference point, 8s delay	27.0	27.8	76.7	8.8	1.8	-1.9
Indifference point function ln k	18.4	25.7	75.8	-8.7	0.7	-0.8
Indifference point function log k	18.4	25.7	75.8	-8.7	0.7	-0.8
Patch foraging total patch changes 0 sec	12.8	20.7	37.9	-6.2	3.5	-3.4
Patch foraging total patch changes 12 sec	4.4	5.7	6.0	-2.4	2.4	-2.4
Patch foraging total patch changes 18 sec	18.7	24.0	62.0	-7.9	2.3	-2.2
Patch foraging total patch changes 24 sec	28.3	34.6	94.8	-9.7	2.1	-2.1
Patch foraging total patch changes 6 sec	10.2	15.2	36.6	-6.0	2.2	-2.1
Patch foraging time to switch 0 sec	11.4	17.6	51.7	-7.2	-0.8	0.7
Patch foraging water rate 0 sec	13.2	21.1	63.3	8.0	0.2	-0.2
Patch foraging water rate 12 sec	23.6	36.1	106.4	10.3	1.0	-0.9
Patch foraging water rate 18 sec	3.2	4.4	13.1	3.6	0.0	0.0
Patch foraging water rate 24 sec	4.8	6.7	17.6	-4.2	1.1	-1.2
Patch foraging water rate 6 sec	12.1	17.7	51.8	7.2	0.9	-0.8
Seeking ratio, delayed vs. immediate footshock	2.9	3.4	10.1	3.2	-0.0	0.0
Distance traveled before self-admin	1.9	2.0	5.9	-2.4	-0.1	0.1
Distance traveled after self-admin	4.3	4.8	9.9	-3.1	1.5	-1.5
Extensor digitorum longus weight	0.2	1.0	2.1	1.4	0.6	-0.7
Bone: elastic displacement	4.0	4.5	6.3	2.5	1.9	-1.9
Bone: elastic work	0.6	0.8	0.9	0.8	1.0	-0.9
Bone: endosteal estimation	1.4	3.1	3.4	1.7	1.8	-1.8
Bone: endosteal perimeter	0.3	0.6	1.0	-1.0	-0.7	0.6
Epididymis fat weight	37.8	88.2	259.3	-16.1	-1.7	1.6
Delta time in closed arm before/after self-admin	1.1	1.0	2.1	-1.4	0.7	-0.7
Delta time in open arm before/after self-admin	10.9	10.5	25.7	-5.1	-1.7	1.7
Diff in mean of infusions in LGA sessions	1.5	1.7	3.4	1.8	0.9	-0.9
Delay discount exponential model param	6.8	7.2	17.0	-4.1	-1.5	1.5
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.4	0.6	-0.4
Active lever presses in extinction session 6	9.1	8.9	25.6	5.1	0.8	-0.6
Bone: final force	1.1	1.7	1.7	1.3	1.3	-1.3
Bone: final moment	1.6	2.6	2.8	1.7	1.6	-1.6
Food consumed during 24 hour testing period	5.3	6.4	19.0	4.4	0.2	-0.2
Glucose	0.0	0.1	0.2	0.4	-0.0	0.0
Heart weight	24.0	34.0	101.6	10.1	0.5	-0.6
Delay discount hyperbolic model param	7.5	7.9	16.8	-4.1	-1.8	1.9
Intermittent access intake day 1-15 change	52.9	52.3	154.9	-12.4	1.0	-1.0
Intermittent access intake escalation	40.4	39.6	115.3	-10.7	1.4	-1.3
Intermittent access intake escalation 2	1.9	1.9	2.3	-1.5	1.3	-1.3
Intermitt. access day 1 inactive lever presses	56.7	60.7	181.7	-13.5	0.4	-0.4
Intermitt. access day 15 inactive lever presses	98.2	107.7	322.8	-18.0	-0.3	0.4
Intermitt. access escalation Index	1.9	1.7	4.4	2.1	-0.5	0.5
Intermittent access day 1 total infusions	23.8	27.6	82.7	9.1	-0.0	-0.0
Intermittent access day 15 total infusions	11.9	13.3	39.7	-6.3	0.4	-0.4
Intermittent access terminal intake (last 3 days)	8.8	9.7	28.2	-5.3	0.6	-0.7
Intermittent access total infusions	0.0	0.0	0.1	-0.3	0.1	-0.2
Intermittent access day 1 locomotion	8.8	9.3	27.8	5.3	0.1	-0.2
Intermittent access day 15 total locomotion	31.7	34.1	100.2	-10.0	1.0	-1.0
Intermittent access total locomotion	4.5	5.1	14.2	-3.8	0.7	-0.8
Intermittent access standard deviation	148.0	156.9	468.9	-21.7	0.9	-0.9
Left kidney weight	9.2	25.8	76.6	8.8	-0.6	0.7
Right kidney weight	18.4	51.6	151.7	12.3	-1.1	1.3
Cocaine induced anxiety	42.2	48.7	144.6	12.0	0.9	-0.8
Post-drug Anxiety	2.0	2.3	2.8	-1.3	1.5	-1.7
Baseline Anxiety	131.3	139.8	419.2	-20.5	-0.1	-0.2
Tail length	42.6	129.1	380.5	-19.5	-1.9	1.8
Length with tail	2.6	9.5	17.5	-4.2	-2.3	2.4
Length without tail	26.3	57.7	169.5	13.0	-1.2	1.4
Times rat made contact with spout	3.1	3.6	10.7	-3.3	0.1	-0.2
Lifetime Intake	0.3	0.3	0.7	0.8	0.2	-0.4
Liver weight, left	0.8	1.3	3.8	-2.0	-0.1	0.2
Liver weight, right	7.8	12.9	29.2	-5.4	-2.2	2.2
Locomotor activity	4.9	7.7	19.6	4.4	1.4	-1.3
Locomotor testing distance	17.7	29.6	78.7	8.9	2.3	-2.2
Locomotor testing rearing	36.9	56.9	153.7	12.4	3.0	-2.9
Locomotion in novel chamber	1.1	1.3	3.2	1.8	0.6	-0.7
Locomotion in novel chamber post-restriction	4.8	5.8	16.9	4.1	-0.4	0.5
Fecal boli incidents, locomotor time 1	59.1	64.6	193.2	13.9	-0.5	0.7
Change in fecal boli incidents, locomotor task	0.5	0.5	1.3	-1.1	0.3	-0.2
Time >=10cm from walls, locomotor time 1	27.0	27.3	79.9	8.9	1.0	-0.9
Bouts of movement, locomotor time 1	2.1	2.3	6.7	-2.6	-0.2	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.2	0.2	-0.2
Rest time, locomotor task time 1	3.9	4.3	12.6	3.6	0.2	-0.3
Distance moved, locomotor task time 1	0.3	0.4	1.0	1.0	0.2	-0.0
Vertical activity count, locomotor time 1	32.6	34.1	102.3	10.1	0.1	0.3
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.6	0.6	0.7	-0.8
Bouts of movement, locomotor time 2	8.1	8.7	25.8	-5.1	0.3	-0.5
Total resting periods, locomotor time 2	12.3	13.1	38.7	-6.2	0.4	-0.7
Rest time, locomotor task time 2	15.6	18.0	51.6	7.2	1.1	-1.1
Distance moved, locomotor task time 2	28.0	32.4	97.3	-9.9	-0.0	-0.0
Vertical activity count, locomotor time 2	5.0	5.4	14.3	-3.8	-0.9	1.0
Light reinforcement 1	8.3	15.2	35.1	5.9	2.3	-2.3
Light reinforcement 2	3.1	4.2	8.8	3.0	1.4	-1.4
Bone: marrow area	1.5	3.2	3.4	1.7	1.8	-1.9
Bone: maximum diameter	0.4	0.8	1.2	-1.1	-0.8	0.8
Bone: maximum force	1.7	3.0	3.0	1.7	1.7	-1.7
Bone: maximum moment	2.5	4.3	4.6	2.1	2.0	-2.1
Mean time between licks in bursts	4.5	6.3	13.0	-3.6	1.8	-1.7
Mean num. licks in bursts	6.6	7.8	21.7	4.7	1.0	-0.9
Cd content in liver	1.3	1.5	1.5	1.2	1.2	-1.2
Co content in liver	2.9	3.4	3.4	1.9	1.9	-1.9
Cu content in liver	1.1	1.3	1.3	-1.1	-1.2	1.1
Fe content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
K content in liver	0.4	0.4	0.4	-0.6	-0.6	0.6
Mg content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Mn content in liver	0.4	0.5	0.5	0.7	0.7	-0.7
Na content in liver	0.1	0.1	0.2	-0.4	-0.4	0.4
Rb content in liver	0.5	0.7	0.7	-0.8	-0.8	0.8
Se content in liver	1.0	1.2	1.2	-1.1	-1.1	1.1
Sr content in liver	0.0	0.0	0.0	0.1	0.2	-0.1
Zn content in liver	0.1	0.1	0.2	-0.4	-0.4	0.4
Bone: minimum diameter	0.7	1.3	1.3	1.1	1.2	-1.2
Time in familiar zone, hab. session 1	4.2	3.9	3.9	-2.0	-2.0	2.0
Time in novel zone, hab. session 1	1.8	1.8	1.8	1.3	1.3	-1.3
Total zone transitions, hab. session 1	0.2	0.3	0.3	0.6	0.6	-0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.3	0.3	-0.3
Locomotion velocity, hab. session 1	0.2	0.2	0.2	0.5	0.5	-0.5
Time in familiar zone, hab. session 2	2.4	2.5	2.6	-1.6	-1.6	1.6
Time in novel zone, hab. session 2	3.0	3.0	3.2	1.6	1.8	-1.8
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.1	-0.1	0.1
Total locomotion distance, hab. session 2	0.0	0.0	0.1	-0.3	0.0	-0.0
Locomotion velocity, hab. session 2	0.2	0.3	0.6	-0.7	-0.4	0.4
Novel to familiar place preference ratio	1.0	1.0	1.6	-1.3	-0.9	0.9
Novelty place preference	0.5	0.5	0.9	-1.0	-0.5	0.5
Time in novel zone, NPP test	0.2	0.2	0.5	-0.7	-0.3	0.3
Total zone transitions, NPP test	0.0	0.0	0.1	0.3	-0.0	0.0
Total locomotion distance, NPP test	0.2	0.2	0.3	0.3	0.5	-0.6
Locomotion velocity, NPP test	0.2	0.2	0.3	0.2	0.5	-0.5
Intraocular pressure	17.9	24.9	72.0	8.5	1.2	-1.1
Delta distance traveled before/after self-admin	3.1	3.4	3.7	-1.7	1.9	-1.9
Delta ambulatory time before/after self-admin	5.5	6.0	6.8	2.6	2.3	-2.4
Parametrial fat weight	4.2	8.2	19.5	4.4	-1.6	1.6
Pavlov. Cond. lever latency	0.4	0.6	0.6	0.7	0.8	-0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	-0.6	-0.4	0.4
Pavlov. Cond. change in total contacts	0.3	0.3	0.3	-0.4	-0.6	0.6
Pavlov. Cond. index score	1.4	1.7	1.9	-1.4	-1.3	1.3
Pavlov. Cond. latency score	0.9	1.2	1.3	-1.1	-1.1	1.1
Pavlov. Cond. lever contacts	0.8	1.0	1.0	-1.0	-1.0	1.0
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.5	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.2	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	2.3	-1.5	-1.5	1.4
Pavlov. Cond. response bias	0.7	0.8	0.9	-1.0	-0.9	0.9
Pavlov. Cond. lever latency	0.6	0.8	1.3	-0.5	-1.1	1.0
Pavlov. Cond. magazine entry latency	0.3	0.3	1.0	-1.0	-0.0	0.1
Pavlov. Cond. change in total contacts	0.9	1.3	3.4	-1.9	0.5	-0.4
Pavlov. Cond. index score	0.6	0.7	1.1	0.6	1.1	-0.9
Pavlov. Cond. latency score	0.3	0.4	0.6	0.4	0.8	-0.6
Pavlov. Cond. lever contacts	1.0	1.4	2.3	0.5	1.5	-1.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.3	0.6	-0.6	0.5
Pavlov. Cond. intertrial magazine entries	1.1	1.5	4.1	2.0	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.1	0.9	-0.7
Pavlov. Cond. response bias	1.0	1.4	2.4	0.3	1.5	-1.3
Time in closed arm before self-admin	15.8	17.8	50.1	7.1	-1.2	1.3
Time in closed arm after self-admin	1.3	1.3	2.8	-1.7	0.8	-0.8
Time in open arm before self-admin	8.9	9.6	26.8	5.2	1.0	-1.1
Time in open arm after self-admin	0.9	1.0	1.2	-0.8	-1.1	1.1
Bone: periosteal estimation	0.5	1.1	1.3	0.8	1.1	-1.2
Bone: periosteal perimeter	0.4	0.7	1.3	-1.1	-0.6	0.6
Bone: post-yield work	0.5	0.7	0.7	0.8	0.8	-0.9
Progressive ratio test 1 active lever presses	8.8	9.2	27.6	-5.3	-0.3	0.1
Progressive ratio test 1 breakpoint	6.4	6.7	20.1	-4.5	0.1	-0.2
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.7	-0.9	-0.3	0.3
Progressive ratio test 2 active lever presses	36.7	39.5	117.6	10.8	0.6	-0.6
Progressive ratio test 2 breakpoint	35.8	40.2	119.7	10.9	0.6	-0.6
Progressive ratio test 2 inactive lever presses	21.3	24.6	73.3	-8.6	0.4	-0.6
Incentive Sensitization - Responses	103.4	104.9	314.3	17.7	0.5	-0.4
Incentive Sensitization - Breakpoint	100.2	102.2	306.3	17.5	0.4	-0.3
Sum of active levers in priming session hrs 5-6	2.5	2.4	6.7	2.6	-0.5	0.6
Progressive ratio	0.5	0.6	1.0	1.0	-0.6	0.6
Food seeking constrained by brief footshock	6.1	7.5	18.4	-4.3	1.4	-1.5
Seeking ratio, punishment vs. effort	2.5	3.1	5.2	-2.3	1.4	-1.4
Retroperitoneal fat weight	4.1	13.6	24.7	-5.0	-2.8	2.8
Reaction time number correct	38.3	55.2	165.5	12.9	0.2	-0.1
Reaction time mean minus median	59.7	78.9	236.8	-15.4	-0.2	0.1
Reaction time mean minus median AUC	77.5	100.7	302.1	-17.4	-0.3	0.1
Reaction time num false alarms	2.0	2.8	7.7	2.8	-0.5	0.6
Reaction time num false alarms AUC	9.3	12.8	37.8	6.1	-0.4	0.5
Reaction time trials correct on left	38.3	55.2	165.5	12.9	0.2	-0.1
Reaction time trials on left	35.6	50.9	152.5	12.3	0.3	-0.1
Reaction time mean	13.2	18.4	50.4	-7.1	-1.5	1.6
Reaction time mean AUC	12.1	16.3	45.4	-6.7	-1.3	1.4
Median of all reaction times	7.4	10.2	24.2	-4.9	-1.8	1.8
Reaction time omissions	15.5	21.2	63.6	-8.0	0.1	-0.3
Reaction time false alarm rate	1.4	2.0	5.5	-2.3	-0.4	0.4
Reaction time premature initiation rate	0.1	0.1	0.2	0.4	-0.3	0.3
Reaction time premature initiations	13.9	19.6	58.7	7.7	-0.3	0.3
Std. dev. reaction times	25.0	35.1	102.5	-10.1	-1.2	1.2
Reaction time trials completed	35.6	50.9	152.5	12.3	0.3	-0.1
Reaction time trials AUC	36.3	52.2	156.6	12.5	0.1	0.1
Run reversals in cocaine runway, females	12.2	11.8	35.3	5.9	-0.3	0.2
Run reversals in cocaine runway, males	2.8	2.7	2.7	-1.6	-1.6	1.6
Latency to leave start box in cocaine runway	11.6	12.5	37.0	6.1	0.5	-0.5
Latency to leave start box in cocaine runway, F	10.7	11.7	34.9	5.9	0.3	-0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	0.4	0.6	0.6	-0.6
Std. dev. time between licks in bursts	4.7	5.6	14.5	-3.8	1.0	-1.1
Total sessions with >9 infusions	0.7	0.8	1.9	-1.4	-0.6	0.5
Short access day 1 total inactive lever presses	7.5	8.3	24.5	4.9	-0.5	0.5
Short access day 10 total inactive lever presses	14.4	15.9	47.7	-6.9	-0.1	0.3
Short access day 1 total infusions	1.4	1.5	4.1	-2.0	0.3	-0.5
Short access day 10 total infusions	1.4	1.5	4.5	-2.1	0.1	-0.2
Short access total infusions	0.4	0.4	0.8	0.2	0.7	-0.9
Short access day 1 locomotion	44.6	47.9	138.5	-11.8	1.5	-1.7
Short access day 10 total locomotion	144.2	161.2	483.4	-22.0	0.2	-0.4
Short access total locomotion	70.2	73.0	218.3	-14.8	0.4	-0.6
One hour access (0.3 mA shock)	7.5	8.8	26.4	5.1	0.2	-0.1
Compulsive drug intake	23.6	23.9	69.1	-8.3	1.1	-1.1
One hour access (shock baseline)	0.6	0.7	1.3	1.1	-0.6	0.6
Social response proportion	3.3	3.6	6.5	2.6	-1.5	1.5
Social responses	0.2	0.2	0.6	0.8	-0.3	0.2
Social time	0.4	0.6	1.7	-1.3	0.2	-0.2
Soleus weight	1.1	3.3	3.6	1.7	1.8	-1.9
Bone: stiffness	0.5	0.8	0.9	0.9	0.9	-0.9
Tibialis anterior weight	0.7	2.4	5.6	2.4	0.9	-0.9
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.1	1.4	0.7	-0.5
Time to tail flick, vehicle, after self-admin	33.0	35.3	80.9	-9.0	-3.6	3.4
Time to tail flick, test, before self-admin	3.7	3.6	10.4	-3.2	-0.4	0.3
Time to tail flick, test, after self-admin	2.6	2.7	5.8	-2.4	-1.1	1.0
Delta time to tail flick, vehicle, before/after SA	32.3	32.0	73.9	-8.6	-3.4	3.2
Delta time to tail flick, test, before/after SA	0.5	0.5	0.7	0.8	-0.6	0.6
Tibia length	0.5	1.5	3.5	1.9	-0.7	0.8
Ambulatory time before self-admin	8.5	8.8	26.3	-5.1	-0.1	0.1
Ambulatory time after self-admin	3.4	3.7	5.2	-2.3	1.7	-1.7
Bone: tissue strength	1.9	1.9	2.2	1.5	1.4	-1.3
Total heroin consumption	1.1	1.3	3.7	-1.9	-0.4	0.3
Bone: trabecular number	0.0	0.0	0.0	0.1	-0.1	0.1
Bone: trabecular spacing	0.3	0.4	0.5	0.4	0.7	-0.7
Bone: trabecular thickness	0.1	0.1	0.1	-0.3	-0.2	0.3
Bone: trabecular tissue density	0.4	0.5	0.7	0.8	0.7	-0.7
Water consumed over 24 hours	11.6	13.9	41.2	6.4	0.4	-0.6
Number of responses in last shaping day	23.0	23.9	70.2	-8.4	-0.9	0.7