Hub : Genes

Zc3h10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA isoform ratio XM_008765041.4 0.05 0.04 3.4e-03 0.02 0.02 0.02 0.02 1.9e-02 2.5e-02 2.4e-02 2.6e-02
2 NAcc gene expression Zc3h10 0.02 0.02 7.0e-03 0.02 0.01 0.01 0.01 6.4e-04 6.3e-03 2.2e-02 2.3e-03
3 Liver gene expression Zc3h10 0.06 0.04 5.9e-05 0.03 0.03 0.02 0.02 3.0e-04 1.1e-04 2.0e-03 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.52.76.21.20.52.5
Area under the delay curve0.20.20.50.7-0.10.3
BMI with tail5.920.531.35.6-5.31.3
BMI without tail1.75.18.22.9-2.60.5
Body weight0.94.06.32.5-2.4-0.1
Weight adjusted by age0.10.10.2-0.30.1-0.4
Bone surface2.74.912.00.71.53.5
Bone volume2.95.313.01.11.33.6
Breakpoint value in progressive ratio session1.01.22.3-1.51.0-0.5
Number of licking bursts1.82.95.01.9-2.2-0.4
Context. condit. distance diff. score0.20.20.40.4-0.70.1
Locomotion velocity, session 11.01.12.40.90.31.6
Locomotion distance, session 10.91.22.60.11.01.6
Locomotion velocity, session 21.61.92.7-0.81.61.5
Locomotion distance, session 22.23.16.6-1.12.61.3
Locomotion velocity, session 33.64.16.0-2.52.4-0.8
Locomotion distance, session 30.10.10.1-0.40.3-0.3
Stereotopy head waving bouts, day 33.84.56.8-2.62.6-0.2
Stereotopy head waving duration, day 32.73.25.5-2.32.0-0.3
Locomotion velocity, session 70.10.10.2-0.30.30.5
Locomotion distance, session 70.20.30.60.0-0.6-0.8
Stereotopy head waving bouts, day 70.91.01.7-0.51.31.0
Stereotopy head waving duration, day 71.01.21.8-0.31.41.3
Locomotion velocity, session 81.51.83.1-0.31.81.5
Locomotion distance, session 80.20.40.8-0.40.90.4
Degree of sensitization distance0.50.50.80.9-0.80.3
Degree of sensitization stereotypy0.50.51.20.60.11.1
Conditioned locomotion1.11.32.20.6-1.5-1.2
Cocaine response after cond. corrected1.82.24.51.2-2.1-0.8
Cocaine response after cond. not corrected1.92.34.61.1-2.1-1.0
Cocaine response before conditioning0.50.61.0-0.81.00.0
Saline control response0.40.60.80.9-0.9-0.5
Bone: connectivity density0.81.33.10.80.41.7
Bone: cortical apparent density0.91.21.91.2-1.40.6
Bone: cortical area1.42.24.31.4-0.52.1
Bone: cortical porosity0.20.20.60.00.10.8
Bone: cortical porosity0.50.61.60.40.01.3
Bone: cortical thickness1.42.42.91.7-1.21.6
Bone: cortical thickness0.60.71.40.8-1.2-0.3
Bone: cortical tissue density0.60.91.31.0-1.20.5
Condit. Reinf. active minus inactive responses1.41.62.7-1.61.4-0.3
Condit. Reinf. active-inactive response ratio0.40.50.8-0.90.2-0.7
Condit. Reinf. active responses1.92.44.0-1.82.00.4
Condit. Reinf. inactive responses1.31.63.2-0.91.80.9
Incentive salience index mean0.91.12.0-1.11.40.5
Condit. Reinf. lever presses1.01.42.70.11.11.7
Condit. Reinf. active minus inactive responses2.43.14.8-2.21.4-1.6
Condit. Reinf. active-inactive response ratio1.82.14.1-1.40.3-2.0
Condit. Reinf. active responses1.42.03.2-1.81.5-0.7
Condit. Reinf. inactive responses0.30.40.6-0.50.80.5
Condit. Reinf. lever presses2.23.04.5-2.11.6-1.3
Condit. Reinf. lever reinforcers received1.21.72.7-1.71.1-1.0
Conditioned reinforcement - actives0.10.20.6-0.2-0.7-0.1
Conditioned reinforcement - inactives0.50.71.6-0.0-1.3-0.7
Conditioned locomotion1.41.83.9-2.01.20.0
Patch foraging indifference point 0 sec2.44.56.22.5-2.31.4
Patch foraging indifference point AUC0.50.71.1-1.00.8-0.6
Delay disc. indifference point, 0s delay3.13.45.22.3-0.62.2
Delay disc. indifference point, 16s delay0.10.20.3-0.30.60.1
Delay disc. indifference point, 2s delay0.70.81.31.2-0.11.1
Delay disc. indifference point, 24s delay0.30.40.91.0-0.30.3
Delay disc. indifference point, 4s delay0.50.50.90.10.80.9
Delay disc. indifference point, 8s delay0.30.40.50.6-0.7-0.6
Indifference point function ln k0.00.10.2-0.0-0.4-0.0
Indifference point function log k0.00.10.2-0.0-0.4-0.0
Patch foraging total patch changes 0 sec2.13.95.32.3-2.21.3
Patch foraging total patch changes 12 sec1.41.83.11.5-1.8-0.0
Patch foraging total patch changes 18 sec0.00.10.10.3-0.10.3
Patch foraging total patch changes 24 sec0.40.71.11.0-0.50.8
Patch foraging total patch changes 6 sec1.42.12.81.7-1.60.9
Patch foraging time to switch 0 sec0.40.91.51.2-0.21.1
Patch foraging water rate 0 sec0.40.81.50.4-1.2-0.8
Patch foraging water rate 12 sec0.51.02.00.4-1.4-0.8
Patch foraging water rate 18 sec1.62.55.9-0.9-0.9-2.4
Patch foraging water rate 24 sec2.53.55.30.4-2.3-2.3
Patch foraging water rate 6 sec1.52.23.9-1.6-0.0-2.0
Seeking ratio, delayed vs. immediate footshock0.81.01.4-1.11.20.4
Distance traveled before self-admin1.01.32.1-1.41.4-0.3
Distance traveled after self-admin0.00.00.00.20.2-0.0
Extensor digitorum longus weight3.815.125.64.4-5.1-0.0
Bone: elastic displacement0.00.00.0-0.1-0.00.2
Bone: elastic work0.91.21.81.3-0.71.1
Bone: endosteal estimation0.51.11.41.1-0.71.2
Bone: endosteal perimeter0.40.91.4-0.51.21.0
Epididymis fat weight0.20.82.1-0.6-0.3-1.4
Delta time in closed arm before/after self-admin2.52.43.90.2-2.0-1.8
Delta time in open arm before/after self-admin0.80.81.91.4-0.70.3
Diff in mean of infusions in LGA sessions1.62.03.6-1.91.3-0.7
Delay discount exponential model param0.10.10.3-0.6-0.0-0.2
Extinction: sum of active levers before priming1.71.93.0-1.70.8-1.4
Active lever presses in extinction session 60.20.20.3-0.40.60.3
Bone: final force3.15.07.32.7-1.42.4
Bone: final moment3.14.97.22.7-1.42.4
Food consumed during 24 hour testing period0.30.40.70.8-0.60.3
Glucose1.01.63.11.8-1.30.4
Heart weight0.40.61.0-0.90.1-1.0
Delay discount hyperbolic model param0.40.40.9-0.90.1-0.6
Intermittent access intake day 1-15 change0.71.42.7-1.70.1-1.2
Intermittent access intake escalation0.61.32.4-1.60.1-1.2
Intermittent access intake escalation 21.01.22.3-1.50.7-0.9
Intermitt. access day 1 inactive lever presses0.51.83.8-1.30.1-1.9
Intermitt. access day 15 inactive lever presses0.51.01.6-1.30.9-0.8
Intermitt. access escalation Index0.40.51.10.50.51.0
Intermittent access day 1 total infusions0.10.20.40.5-0.6-0.2
Intermittent access day 15 total infusions0.00.00.1-0.3-0.2-0.1
Intermittent access terminal intake (last 3 days)0.10.10.2-0.30.20.4
Intermittent access total infusions0.10.10.30.2-0.50.2
Intermittent access day 1 locomotion0.30.40.7-0.1-0.6-0.8
Intermittent access day 15 total locomotion0.40.81.4-1.2-0.2-0.9
Intermittent access total locomotion0.20.20.3-0.5-0.3-0.6
Intermittent access standard deviation0.51.12.0-1.41.10.1
Left kidney weight0.00.10.20.1-0.2-0.4
Right kidney weight0.10.50.8-0.80.3-0.9
Cocaine induced anxiety1.11.63.2-0.91.80.9
Post-drug Anxiety1.71.82.8-0.21.61.7
Baseline Anxiety0.00.00.00.20.00.1
Tail length2.610.014.6-3.83.5-1.7
Length with tail1.25.37.6-2.82.2-1.8
Length without tail0.20.51.00.6-1.0-0.4
Times rat made contact with spout0.91.01.71.0-1.3-0.4
Lifetime Intake0.40.50.90.7-0.90.5
Liver weight, left0.40.61.10.9-1.10.1
Liver weight, right0.10.20.5-0.20.3-0.7
Locomotor activity2.33.67.0-1.92.70.3
Locomotor testing distance1.01.83.4-1.31.80.3
Locomotor testing rearing0.00.10.2-0.20.0-0.5
Locomotion in novel chamber0.00.00.00.1-0.10.1
Locomotion in novel chamber post-restriction2.64.36.6-2.42.6-0.7
Fecal boli incidents, locomotor time 10.40.60.80.8-0.9-0.6
Change in fecal boli incidents, locomotor task1.01.01.6-0.41.31.1
Time >=10cm from walls, locomotor time 11.01.12.11.1-0.21.4
Bouts of movement, locomotor time 10.60.71.0-1.00.7-0.6
Total resting periods, locomotor time 11.11.21.8-1.31.2-0.5
Rest time, locomotor task time 10.50.61.3-0.51.20.3
Distance moved, locomotor task time 10.91.42.51.1-0.61.6
Vertical activity count, locomotor time 10.51.22.90.9-1.70.2
Time >=10cm from walls, locomotor time 20.50.81.50.9-1.2-0.3
Bouts of movement, locomotor time 20.30.50.8-0.10.80.9
Total resting periods, locomotor time 20.40.71.20.00.91.1
Rest time, locomotor task time 20.40.50.80.20.90.9
Distance moved, locomotor task time 20.30.40.7-0.3-0.7-0.8
Vertical activity count, locomotor time 21.11.53.10.6-1.8-0.9
Light reinforcement 12.15.28.0-2.82.8-0.2
Light reinforcement 20.81.21.8-1.31.3-0.2
Bone: marrow area0.40.91.31.0-0.71.1
Bone: maximum diameter0.61.21.8-0.51.21.3
Bone: maximum force2.74.87.42.7-1.62.2
Bone: maximum moment2.84.87.42.7-1.62.1
Mean time between licks in bursts0.41.02.2-1.50.7-0.6
Mean num. licks in bursts0.40.61.1-0.91.00.0
Cd content in liver0.20.30.7-0.90.3-0.0
Co content in liver2.32.64.3-2.11.5-1.2
Cu content in liver0.70.82.10.5-0.21.5
Fe content in liver0.20.20.60.1-0.8-0.3
K content in liver0.70.71.2-0.61.10.6
Mg content in liver0.80.81.6-0.81.30.2
Mn content in liver2.42.63.8-0.61.91.9
Na content in liver0.40.40.90.60.00.9
Rb content in liver0.70.92.30.50.11.5
Se content in liver0.00.00.0-0.10.0-0.0
Sr content in liver0.50.50.7-0.8-0.1-0.8
Zn content in liver3.74.15.5-2.31.2-2.3
Bone: minimum diameter0.50.92.10.8-0.11.5
Time in familiar zone, hab. session 13.93.75.3-2.32.1-1.3
Time in novel zone, hab. session 13.63.64.82.2-1.51.9
Total zone transitions, hab. session 10.81.11.8-0.01.21.3
Total locomotion distance, hab. session 12.02.94.7-0.72.21.8
Locomotion velocity, hab. session 11.82.54.8-1.02.21.3
Time in familiar zone, hab. session 24.64.87.7-2.81.8-1.8
Time in novel zone, hab. session 25.25.38.12.8-1.82.1
Total zone transitions, hab. session 21.72.25.01.3-0.02.2
Total locomotion distance, hab. session 20.70.91.3-0.11.21.2
Locomotion velocity, hab. session 21.01.32.2-0.01.31.5
Novel to familiar place preference ratio3.23.44.72.2-1.22.1
Novelty place preference2.22.43.41.7-0.91.8
Time in novel zone, NPP test2.62.83.61.9-1.21.8
Total zone transitions, NPP test0.81.11.81.3-0.11.3
Total locomotion distance, NPP test0.70.92.10.70.41.4
Locomotion velocity, NPP test0.50.81.60.40.71.3
Intraocular pressure0.81.12.9-0.70.1-1.7
Delta distance traveled before/after self-admin0.60.61.11.1-0.80.0
Delta ambulatory time before/after self-admin0.70.81.61.3-0.60.6
Parametrial fat weight0.30.81.51.2-0.70.7
Pavlov. Cond. lever latency0.70.92.2-0.3-0.6-1.5
Pavlov. Cond. magazine entry latency1.01.32.2-1.51.2-0.4
Pavlov. Cond. change in total contacts0.20.20.30.3-0.50.3
Pavlov. Cond. index score0.30.40.6-0.50.80.6
Pavlov. Cond. latency score0.50.70.9-0.41.00.9
Pavlov. Cond. lever contacts0.70.82.10.50.31.4
Pavlov. Cond. magazine entry number0.40.50.91.0-0.70.4
Pavlov. Cond. intertrial magazine entries0.40.51.2-0.6-0.1-1.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.60.80.5
Pavlov. Cond. response bias0.30.40.6-0.80.6-0.2
Pavlov. Cond. lever latency1.11.52.61.3-1.60.5
Pavlov. Cond. magazine entry latency1.51.83.3-1.41.8-0.4
Pavlov. Cond. change in total contacts0.50.81.3-1.10.9-0.6
Pavlov. Cond. index score1.41.92.7-1.61.6-0.6
Pavlov. Cond. latency score1.52.03.4-1.51.9-0.4
Pavlov. Cond. lever contacts1.11.52.0-1.41.4-0.8
Pavlov. Cond. magazine entry number1.51.93.11.5-1.80.3
Pavlov. Cond. intertrial magazine entries0.71.02.00.9-1.4-0.3
Pavlov. Cond. lever-magazine prob. diff.1.52.03.1-1.71.7-0.5
Pavlov. Cond. response bias1.72.33.2-1.81.7-1.0
Time in closed arm before self-admin0.50.61.50.60.21.2
Time in closed arm after self-admin0.20.20.70.2-0.8-0.1
Time in open arm before self-admin0.10.10.3-0.5-0.1-0.2
Time in open arm after self-admin1.31.42.41.6-1.3-0.0
Bone: periosteal estimation1.22.64.91.6-0.62.2
Bone: periosteal perimeter0.61.12.90.30.61.7
Bone: post-yield work0.40.61.01.0-0.90.4
Progressive ratio test 1 active lever presses0.40.50.90.7-0.9-0.1
Progressive ratio test 1 breakpoint0.40.50.90.7-0.9-0.1
Progressive ratio test 1 inactive lever presses0.20.30.6-0.80.4-0.2
Progressive ratio test 2 active lever presses0.00.00.1-0.3-0.0-0.1
Progressive ratio test 2 breakpoint0.10.10.2-0.40.1-0.1
Progressive ratio test 2 inactive lever presses0.10.20.40.3-0.40.6
Incentive Sensitization - Responses0.20.30.7-0.80.5-0.4
Incentive Sensitization - Breakpoint0.30.50.8-0.90.7-0.2
Sum of active levers in priming session hrs 5-60.20.20.3-0.60.3-0.3
Progressive ratio0.60.91.90.9-1.4-0.2
Food seeking constrained by brief footshock1.31.62.6-1.31.6-0.7
Seeking ratio, punishment vs. effort1.42.13.7-1.51.9-0.5
Retroperitoneal fat weight1.46.211.12.6-3.3-0.7
Reaction time number correct0.61.12.10.8-1.4-0.8
Reaction time mean minus median0.51.22.2-1.31.5-0.1
Reaction time mean minus median AUC0.82.04.0-0.82.01.2
Reaction time num false alarms0.50.71.11.0-1.00.0
Reaction time num false alarms AUC0.50.71.30.9-1.1-0.3
Reaction time trials correct on left0.61.12.10.8-1.4-0.8
Reaction time trials on left0.51.02.00.8-1.4-0.7
Reaction time mean0.81.32.6-0.91.60.7
Reaction time mean AUC0.50.71.3-0.51.10.8
Median of all reaction times0.60.91.5-0.61.20.8
Reaction time omissions0.20.30.8-0.00.30.9
Reaction time false alarm rate0.20.20.40.7-0.30.4
Reaction time premature initiation rate1.52.02.7-1.71.0-1.5
Reaction time premature initiations1.11.94.0-1.30.2-2.0
Std. dev. reaction times0.40.81.7-0.71.30.5
Reaction time trials completed0.51.02.00.8-1.4-0.7
Reaction time trials AUC0.71.32.40.8-1.6-0.9
Run reversals in cocaine runway, females2.02.04.2-1.32.00.4
Run reversals in cocaine runway, males1.91.93.6-1.41.90.5
Latency to leave start box in cocaine runway1.11.22.61.00.31.6
Latency to leave start box in cocaine runway, F1.82.14.71.10.52.2
Latency to leave start box in cocaine runway, M0.10.10.30.0-0.4-0.5
Std. dev. time between licks in bursts0.71.01.4-0.81.21.0
Total sessions with >9 infusions0.20.30.50.3-0.70.5
Short access day 1 total inactive lever presses0.50.61.0-1.00.3-0.9
Short access day 10 total inactive lever presses0.61.53.4-1.0-0.2-1.9
Short access day 1 total infusions0.20.30.60.1-0.80.5
Short access day 10 total infusions0.10.10.20.3-0.40.0
Short access total infusions0.40.60.90.6-0.90.7
Short access day 1 locomotion0.50.61.3-1.10.2-0.7
Short access day 10 total locomotion2.13.86.8-2.60.5-2.1
Short access total locomotion0.50.71.3-1.10.1-0.8
One hour access (0.3 mA shock)0.20.30.60.3-0.8-0.3
Compulsive drug intake0.00.00.10.10.20.3
One hour access (shock baseline)0.10.20.2-0.5-0.2-0.5
Social response proportion0.80.92.0-0.71.40.2
Social responses6.58.416.1-3.04.0-0.1
Social time0.71.01.61.1-1.2-0.2
Soleus weight4.413.019.84.5-4.21.3
Bone: stiffness3.45.58.42.9-2.11.9
Tibialis anterior weight1.13.65.52.3-2.20.6
Time to tail flick, vehicle, before self-admin1.11.12.0-1.01.40.6
Time to tail flick, vehicle, after self-admin0.91.12.4-1.00.3-1.5
Time to tail flick, test, before self-admin0.80.81.3-0.41.11.0
Time to tail flick, test, after self-admin0.10.10.40.10.20.6
Delta time to tail flick, vehicle, before/after SA1.41.31.80.8-1.3-1.2
Delta time to tail flick, test, before/after SA0.60.61.5-0.3-0.5-1.2
Tibia length0.61.82.3-1.51.5-1.0
Ambulatory time before self-admin0.30.40.8-0.90.7-0.3
Ambulatory time after self-admin0.00.00.10.20.10.1
Bone: tissue strength3.94.05.92.4-2.01.4
Total heroin consumption1.61.93.5-1.51.90.0
Bone: trabecular number0.71.11.90.21.11.4
Bone: trabecular spacing1.82.45.5-0.7-1.1-2.3
Bone: trabecular thickness4.05.012.11.41.03.5
Bone: trabecular tissue density3.24.78.52.4-2.9-0.0
Water consumed over 24 hours0.81.01.51.2-0.51.2
Number of responses in last shaping day2.32.55.4-2.30.7-1.3