Zc3h10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	alternative TSS	XM_008765041.3	0.05	0.04	6.9e-03	0.02	0.03	0.02	0.02	2.0e-02	1.3e-02	2.3e-02	2.6e-02
2	PL	isoform ratio	XM_008765041.3	0.04	0.03	9.5e-05	0.02	0.03	0.02	0.02	2.6e-03	8.2e-04	1.7e-03	3.1e-03
3	pVTA	alternative TSS	XM_039079909.1	0.09	0.07	4.8e-03	0.03	0.05	0.04	0.05	1.3e-02	4.3e-03	8.7e-03	3.1e-03
4	pVTA	alternative TSS	XM_039079909.1	0.1	0.08	2.0e-03	0.05	0.05	0.04	0.06	2.3e-03	2.8e-03	5.2e-03	2.2e-03
5	PL	alternative TSS	XM_008765041.3	0.04	0.03	1.5e-04	0.03	0.03	0.03	0.03	4.1e-04	3.6e-04	6.8e-04	7.0e-04
6	PL	alternative TSS	XM_008765041.3	0.04	0.03	7.8e-05	0.03	0.03	0.03	0.03	3.3e-04	2.1e-04	6.2e-04	4.0e-04
7	Liver	gene expression	Zc3h10	0.06	0.04	1.2e-04	0.03	0.03	0.02	0.01	7.9e-04	3.3e-04	5.1e-03	7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.7	1.1	6.9	-0.1	0.4	-0.4	-0.2	0.5	0.6	2.6
Area under the delay curve	0.2	0.2	0.3	0.2	0.3	-0.5	-0.5	0.3	0.3	0.5
BMI with tail	7.5	24.4	28.2	5.3	5.3	-5.3	-5.3	5.3	5.2	1.8
BMI without tail	1.4	2.8	3.6	1.9	1.8	-1.8	-1.9	1.7	1.7	0.1
Body weight	1.4	5.9	7.7	2.6	2.5	-2.8	-2.8	2.5	2.5	0.8
Weight adjusted by age	0.1	0.1	0.5	0.0	-0.1	0.1	0.0	-0.1	-0.1	-0.7
Bone surface	1.1	2.0	13.0	-0.6	-0.0	0.2	0.6	0.3	0.3	3.6
Bone volume	1.2	2.1	13.8	-0.3	0.3	-0.1	0.2	0.5	0.6	3.7
Breakpoint value in progressive ratio session	2.5	2.8	3.5	-1.6	-1.7	1.9	1.8	-1.7	-1.7	-1.1
Number of licking bursts	2.9	3.5	4.6	2.1	2.0	-2.1	-2.2	1.9	1.8	-0.3
Context. condit. distance diff. score	0.2	0.2	0.3	0.6	0.5	-0.4	-0.4	0.5	0.5	0.0
Locomotion velocity, session 1	0.5	0.6	2.3	0.3	0.5	-0.6	-0.5	0.6	0.6	1.5
Locomotion distance, session 1	0.3	0.4	2.6	-0.4	-0.2	0.2	0.4	-0.0	-0.0	1.6
Locomotion velocity, session 2	1.0	1.2	2.2	-1.2	-0.9	1.1	1.2	-0.8	-0.8	1.5
Locomotion distance, session 2	1.7	2.3	3.7	-1.9	-1.6	1.3	1.5	-1.5	-1.5	1.2
Locomotion velocity, session 3	4.7	5.5	6.3	-2.5	-2.5	2.5	2.5	-2.5	-2.5	-1.0
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	-0.3	0.2	0.2	-0.3	-0.3	-0.4
Stereotopy head waving bouts, day 3	5.5	6.4	8.0	-2.8	-2.7	2.8	2.8	-2.7	-2.6	-0.4
Stereotopy head waving duration, day 3	4.1	4.9	6.7	-2.4	-2.3	2.5	2.6	-2.2	-2.2	-0.4
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	-0.2	0.4	0.5	-0.2	-0.2	0.5
Locomotion distance, session 7	0.1	0.1	0.6	0.3	0.1	-0.1	-0.2	0.1	0.1	-0.8
Stereotopy head waving bouts, day 7	0.6	0.6	0.9	-0.9	-0.8	0.7	0.8	-0.7	-0.7	0.9
Stereotopy head waving duration, day 7	0.4	0.5	1.5	-0.8	-0.6	0.5	0.6	-0.5	-0.5	1.2
Locomotion velocity, session 8	0.8	0.9	2.1	-1.2	-0.9	0.7	0.9	-0.8	-0.7	1.5
Locomotion distance, session 8	0.2	0.3	0.4	-0.7	-0.6	0.4	0.4	-0.6	-0.5	0.4
Degree of sensitization distance	0.5	0.5	0.6	0.8	0.8	-0.7	-0.7	0.8	0.8	0.4
Degree of sensitization stereotypy	0.4	0.4	1.3	0.3	0.5	-0.6	-0.5	0.5	0.6	1.1
Conditioned locomotion	0.9	1.0	1.4	1.2	0.9	-1.0	-1.2	0.8	0.8	-1.0
Cocaine response after cond. corrected	1.8	2.0	2.8	1.6	1.4	-1.5	-1.7	1.3	1.3	-0.8
Cocaine response after cond. not corrected	1.8	2.0	2.7	1.7	1.4	-1.5	-1.6	1.3	1.3	-1.0
Cocaine response before conditioning	0.5	0.6	0.9	-0.8	-0.8	0.9	1.0	-0.7	-0.7	0.1
Saline control response	0.4	0.6	0.9	0.8	0.7	-0.9	-1.0	0.7	0.7	-0.1
Bone: connectivity density	0.4	0.6	3.7	-0.1	0.2	-0.2	-0.0	0.3	0.3	1.9
Bone: cortical apparent density	1.3	1.7	2.0	1.4	1.4	-1.3	-1.3	1.4	1.4	0.4
Bone: cortical area	1.3	1.9	4.2	1.1	1.3	-1.0	-0.9	1.5	1.5	2.1
Bone: cortical porosity	0.1	0.1	0.4	-0.2	-0.1	0.3	0.3	-0.0	-0.0	0.7
Bone: cortical porosity	0.3	0.3	1.4	0.2	0.4	-0.2	-0.1	0.5	0.5	1.2
Bone: cortical thickness	1.5	2.4	3.0	1.5	1.7	-1.4	-1.3	1.7	1.7	1.4
Bone: cortical thickness	0.7	0.8	1.2	1.1	1.0	-0.9	-0.9	0.9	0.9	-0.2
Bone: cortical tissue density	0.9	1.2	1.4	1.2	1.2	-1.1	-1.1	1.2	1.2	0.3
Condit. Reinf. active minus inactive responses	2.1	2.3	3.1	-1.6	-1.6	1.8	1.8	-1.6	-1.6	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	-0.6	-0.7	0.9	0.8	-0.7	-0.7	-0.7
Condit. Reinf. active responses	2.6	3.2	4.4	-2.0	-1.9	2.0	2.1	-1.8	-1.8	0.3
Condit. Reinf. inactive responses	1.1	1.3	1.9	-1.4	-1.2	1.1	1.2	-1.1	-1.1	0.9
Incentive salience index mean	1.1	1.3	1.8	-1.3	-1.2	1.3	1.3	-1.1	-1.1	0.5
Condit. Reinf. lever presses	0.4	0.5	3.2	-0.5	-0.2	0.0	0.2	-0.1	-0.0	1.8
Condit. Reinf. active minus inactive responses	2.7	3.4	4.0	-1.7	-1.8	2.0	1.9	-1.9	-1.9	-1.6
Condit. Reinf. active-inactive response ratio	1.3	1.4	3.8	-0.7	-1.0	1.0	0.9	-1.1	-1.1	-2.0
Condit. Reinf. active responses	1.7	2.3	3.1	-1.6	-1.6	1.8	1.7	-1.6	-1.6	-0.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	-0.6	0.6	0.7	-0.5	-0.5	0.5
Condit. Reinf. lever presses	3.1	4.2	4.9	-2.0	-2.2	2.1	2.0	-2.2	-2.2	-1.6
Condit. Reinf. lever reinforcers received	1.3	1.9	2.4	-1.3	-1.4	1.5	1.5	-1.4	-1.4	-1.0
Conditioned reinforcement - actives	0.1	0.1	0.5	-0.3	-0.1	0.5	0.5	-0.1	-0.1	0.7
Conditioned reinforcement - inactives	0.5	0.6	1.0	1.0	0.9	-0.4	-0.5	0.8	0.8	-0.7
Conditioned locomotion	3.4	4.1	6.6	-2.1	-2.0	2.5	2.6	-1.9	-1.9	-0.4
Patch foraging indifference point 0 sec	3.5	5.7	6.9	2.5	2.6	-2.4	-2.3	2.6	2.6	1.3
Patch foraging indifference point AUC	0.5	0.6	0.8	-0.9	-0.9	0.6	0.6	-0.9	-0.9	-0.4
Delay disc. indifference point, 0s delay	2.6	2.8	5.1	1.2	1.5	-1.8	-1.6	1.6	1.6	2.3
Delay disc. indifference point, 16s delay	0.2	0.2	0.2	-0.4	-0.4	0.4	0.5	-0.4	-0.4	0.0
Delay disc. indifference point, 2s delay	0.5	0.6	1.1	0.5	0.7	-0.9	-0.8	0.7	0.7	1.0
Delay disc. indifference point, 24s delay	0.5	0.5	0.8	0.7	0.7	-0.9	-0.9	0.7	0.7	0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.8	-0.6	-0.4	0.2	0.3	-0.4	-0.3	0.9
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.4	0.3	-0.6	-0.6	0.2	0.2	-0.5
Indifference point function ln k	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1	0.4	0.4	0.1
Indifference point function log k	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1	0.4	0.4	0.1
Patch foraging total patch changes 0 sec	3.1	5.1	6.2	2.4	2.5	-2.2	-2.2	2.5	2.5	1.1
Patch foraging total patch changes 12 sec	1.6	2.0	2.8	1.6	1.5	-1.6	-1.7	1.4	1.4	-0.2
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2	0.2	0.2	0.1
Patch foraging total patch changes 24 sec	0.7	0.9	1.1	0.9	1.0	-1.0	-1.0	1.0	1.0	0.7
Patch foraging total patch changes 6 sec	1.8	2.6	3.2	1.8	1.8	-1.6	-1.6	1.8	1.8	0.8
Patch foraging time to switch 0 sec	0.4	0.7	1.1	0.6	0.7	-0.9	-0.8	0.8	0.8	1.0
Patch foraging water rate 0 sec	0.3	0.5	0.8	0.9	0.7	-0.5	-0.6	0.7	0.6	-0.8
Patch foraging water rate 12 sec	0.5	0.7	1.2	1.1	0.9	-0.7	-0.8	0.9	0.8	-0.8
Patch foraging water rate 18 sec	0.6	0.9	5.2	0.0	-0.3	0.5	0.2	-0.4	-0.5	-2.3
Patch foraging water rate 24 sec	1.2	1.6	4.9	1.4	1.0	-0.9	-1.2	0.8	0.7	-2.2
Patch foraging water rate 6 sec	1.0	1.5	3.6	-0.7	-1.0	1.3	1.1	-1.1	-1.1	-1.9
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.4	-1.4	-1.2	1.5	1.6	-1.1	-1.1	0.3
Distance traveled before self-admin	0.8	0.9	1.1	-1.1	-1.0	0.9	1.0	-1.0	-1.0	-0.1
Distance traveled after self-admin	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5	-0.4	-0.4	0.2
Extensor digitorum longus weight	5.1	20.2	25.9	5.0	4.8	-5.0	-5.1	4.6	4.6	0.2
Bone: elastic displacement	0.0	0.0	0.1	-0.1	-0.0	0.3	0.3	-0.0	-0.0	0.2
Bone: elastic work	0.8	1.0	1.2	0.9	1.0	-1.0	-0.9	1.1	1.1	1.1
Bone: endosteal estimation	0.6	1.4	1.8	1.1	1.2	-0.9	-0.8	1.3	1.3	1.3
Bone: endosteal perimeter	0.2	0.5	1.2	-0.7	-0.5	0.8	0.9	-0.4	-0.4	1.1
Epididymis fat weight	0.1	0.2	0.3	-0.4	-0.4	0.4	0.4	-0.5	-0.5	-0.6
Delta time in closed arm before/after self-admin	0.8	0.8	3.6	0.8	0.5	-0.4	-0.6	0.4	0.3	-1.9
Delta time in open arm before/after self-admin	2.0	1.9	2.7	1.3	1.4	-1.6	-1.6	1.4	1.4	0.9
Diff in mean of infusions in LGA sessions	2.4	2.7	3.3	-1.7	-1.7	1.8	1.8	-1.7	-1.7	-0.8
Delay discount exponential model param	0.1	0.1	0.2	-0.2	-0.2	0.5	0.4	-0.2	-0.2	-0.5
Extinction: sum of active levers before priming	3.5	3.5	4.1	-1.7	-1.9	1.8	1.6	-2.0	-2.0	-1.9
Active lever presses in extinction session 6	0.9	0.9	1.2	-1.1	-1.1	0.9	1.0	-1.0	-1.0	-0.0
Bone: final force	3.3	5.3	6.0	2.1	2.4	-2.3	-2.2	2.4	2.5	2.2
Bone: final moment	3.1	5.0	5.8	2.1	2.3	-2.2	-2.1	2.4	2.4	2.2
Food consumed during 24 hour testing period	0.4	0.5	0.7	0.7	0.8	-0.8	-0.8	0.8	0.8	0.3
Glucose	1.9	2.9	3.5	1.9	1.8	-1.8	-1.8	1.8	1.8	0.5
Heart weight	0.0	0.0	0.2	0.1	-0.0	0.1	0.1	-0.0	-0.0	-0.5
Delay discount hyperbolic model param	0.2	0.3	0.4	-0.3	-0.4	0.7	0.6	-0.4	-0.4	-0.6
Intermittent access intake day 1-15 change	0.8	0.8	1.7	-0.7	-0.7	1.3	1.2	-0.7	-0.7	-0.7
Intermittent access intake escalation	0.9	0.9	2.5	-0.4	-0.6	1.1	0.9	-0.7	-0.7	-1.6
Intermittent access intake escalation 2	1.5	1.5	2.5	-0.8	-1.0	1.4	1.2	-1.1	-1.1	-1.6
Intermitt. access day 1 inactive lever presses	0.6	0.6	2.3	-0.3	-0.5	0.8	0.7	-0.5	-0.6	-1.5
Intermitt. access day 15 inactive lever presses	1.4	1.6	2.1	-1.0	-1.1	1.5	1.3	-1.2	-1.2	-1.4
Intermitt. access escalation Index	0.3	0.3	1.5	-0.3	-0.1	0.4	0.6	0.0	0.0	1.2
Intermittent access day 1 total infusions	0.4	0.5	0.5	0.6	0.7	-0.7	-0.6	0.7	0.7	0.6
Intermittent access day 15 total infusions	0.0	0.1	0.1	0.3	0.3	0.1	0.0	0.3	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.3	0.4	0.0	0.1	0.4	0.4	0.5
Intermittent access total infusions	0.3	0.3	0.4	0.6	0.6	-0.4	-0.4	0.6	0.6	0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0	-0.1
Intermittent access day 15 total locomotion	0.8	0.9	1.7	-0.8	-0.8	1.3	1.2	-0.8	-0.8	-0.6
Intermittent access total locomotion	0.3	0.3	0.4	-0.6	-0.6	0.6	0.6	-0.5	-0.5	-0.1
Intermittent access standard deviation	0.5	0.6	1.2	-0.5	-0.6	1.1	1.0	-0.6	-0.6	-0.7
Left kidney weight	0.2	0.7	3.1	0.3	0.6	-0.5	-0.3	0.7	0.7	1.7
Right kidney weight	0.2	0.7	1.2	-0.9	-0.7	1.0	1.1	-0.7	-0.7	0.5
Cocaine induced anxiety	1.1	1.2	1.8	-1.4	-1.2	1.0	1.2	-1.1	-1.1	0.7
Post-drug Anxiety	0.4	0.5	2.7	-0.6	-0.3	0.2	0.4	-0.2	-0.2	1.6
Baseline Anxiety	0.0	0.0	0.2	0.1	0.0	-0.1	-0.1	0.0	0.0	-0.4
Tail length	4.7	14.2	16.6	-3.9	-4.0	3.9	3.8	-4.1	-4.1	-2.2
Length with tail	1.4	5.1	6.4	-2.5	-2.5	2.3	2.3	-2.5	-2.5	-0.7
Length without tail	0.2	0.5	1.6	0.4	0.6	-0.7	-0.6	0.6	0.7	1.2
Times rat made contact with spout	0.9	1.1	1.5	1.2	1.1	-1.2	-1.2	1.0	1.0	-0.3
Lifetime Intake	0.8	0.9	1.3	1.0	1.1	-0.8	-0.8	1.1	1.1	0.8
Liver weight, left	1.2	1.9	2.6	1.6	1.5	-1.4	-1.4	1.5	1.5	-0.1
Liver weight, right	0.8	1.3	1.8	1.3	1.3	-1.0	-1.0	1.3	1.3	0.6
Locomotor activity	2.6	4.2	5.6	-2.4	-2.2	2.1	2.3	-2.1	-2.1	0.2
Locomotor testing distance	1.1	1.8	2.5	-1.5	-1.4	1.5	1.6	-1.3	-1.3	0.1
Locomotor testing rearing	0.0	0.0	0.2	0.0	-0.0	0.0	0.0	-0.1	-0.1	-0.5
Locomotion in novel chamber	0.1	0.2	0.2	0.5	0.5	-0.3	-0.3	0.5	0.5	0.1
Locomotion in novel chamber post-restriction	3.4	4.1	4.7	-2.2	-2.2	2.2	2.2	-2.2	-2.1	-0.8
Fecal boli incidents, locomotor time 1	0.6	0.7	1.0	0.9	0.8	-0.9	-1.0	0.7	0.7	-0.8
Change in fecal boli incidents, locomotor task	0.5	0.4	1.3	-0.7	-0.5	0.5	0.6	-0.4	-0.4	1.1
Time >=10cm from walls, locomotor time 1	0.9	1.0	1.9	0.8	0.9	-0.9	-0.8	1.0	1.0	1.4
Bouts of movement, locomotor time 1	0.5	0.6	0.7	-0.8	-0.8	0.8	0.7	-0.8	-0.8	-0.5
Total resting periods, locomotor time 1	1.1	1.2	1.4	-1.2	-1.2	1.1	1.1	-1.2	-1.2	-0.5
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.7	-0.7	0.5	0.5	-0.6	-0.6	0.2
Distance moved, locomotor task time 1	0.9	0.9	1.9	0.8	1.0	-0.7	-0.6	1.0	1.0	1.4
Vertical activity count, locomotor time 1	0.8	0.8	1.2	1.1	1.1	-0.7	-0.8	1.1	1.0	0.1
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.3	1.1	1.1	-1.0	-1.0	1.0	1.0	-0.2
Bouts of movement, locomotor time 2	0.2	0.3	0.8	-0.5	-0.4	0.4	0.5	-0.3	-0.3	0.9
Total resting periods, locomotor time 2	0.2	0.3	1.1	-0.5	-0.3	0.3	0.4	-0.2	-0.2	1.1
Rest time, locomotor task time 2	0.1	0.1	0.8	-0.2	-0.0	-0.0	0.1	0.0	0.0	0.9
Distance moved, locomotor task time 2	0.1	0.1	0.7	0.2	0.1	0.0	-0.0	0.0	-0.0	-0.9
Vertical activity count, locomotor time 2	1.0	1.1	1.6	1.3	1.1	-1.0	-1.1	1.0	1.0	-0.9
Light reinforcement 1	3.6	6.6	8.9	-2.7	-2.7	3.0	3.0	-2.6	-2.6	-0.6
Light reinforcement 2	1.0	1.4	1.9	-1.2	-1.2	1.4	1.4	-1.2	-1.2	-0.3
Bone: marrow area	0.6	1.2	1.6	1.0	1.2	-0.9	-0.8	1.2	1.2	1.3
Bone: maximum diameter	0.4	0.7	2.2	-0.8	-0.5	0.8	1.0	-0.4	-0.3	1.5
Bone: maximum force	3.3	5.7	6.6	2.3	2.5	-2.4	-2.3	2.6	2.6	2.1
Bone: maximum moment	3.2	5.5	6.4	2.3	2.5	-2.3	-2.2	2.5	2.5	2.1
Mean time between licks in bursts	1.1	1.6	1.9	-1.2	-1.3	1.4	1.3	-1.3	-1.3	-1.0
Mean num. licks in bursts	0.7	0.8	1.1	-1.0	-1.0	1.0	1.0	-0.9	-0.9	0.0
Cd content in liver	0.4	0.4	0.6	0.6	0.6	-0.8	-0.8	0.6	0.6	0.3
Co content in liver	1.4	1.6	1.9	-1.2	-1.3	1.3	1.2	-1.4	-1.4	-1.2
Cu content in liver	1.2	1.4	2.8	1.0	1.2	-0.8	-0.7	1.3	1.3	1.7
Fe content in liver	0.4	0.4	0.6	0.8	0.7	-0.7	-0.7	0.6	0.6	-0.3
K content in liver	0.4	0.4	0.6	-0.8	-0.6	0.7	0.7	-0.5	-0.5	0.7
Mg content in liver	0.3	0.3	1.2	-0.6	-0.4	0.2	0.3	-0.3	-0.3	1.1
Mn content in liver	0.8	0.9	5.3	-0.7	-0.3	0.4	0.6	-0.2	-0.1	2.3
Na content in liver	0.2	0.2	0.7	0.3	0.4	-0.4	-0.4	0.4	0.4	0.8
Rb content in liver	0.7	0.9	2.4	0.7	0.9	-0.6	-0.5	1.0	1.0	1.6
Se content in liver	0.0	0.0	0.0	-0.2	-0.2	0.0	0.1	-0.2	-0.2	0.2
Sr content in liver	0.7	0.6	2.1	-0.4	-0.6	0.8	0.6	-0.7	-0.7	-1.5
Zn content in liver	2.7	3.0	5.5	-1.4	-1.7	1.5	1.4	-1.8	-1.8	-2.3
Bone: minimum diameter	0.3	0.7	2.1	0.5	0.7	-0.5	-0.4	0.8	0.8	1.5
Time in familiar zone, hab. session 1	5.2	4.9	5.8	-2.3	-2.4	2.2	2.2	-2.4	-2.4	-1.4
Time in novel zone, hab. session 1	4.2	4.1	4.8	1.9	2.1	-2.0	-1.8	2.2	2.2	2.0
Total zone transitions, hab. session 1	0.3	0.4	1.5	-0.8	-0.5	0.3	0.5	-0.4	-0.4	1.2
Total locomotion distance, hab. session 1	1.2	1.8	3.0	-1.6	-1.2	1.2	1.4	-1.1	-1.0	1.7
Locomotion velocity, hab. session 1	1.4	1.9	2.8	-1.7	-1.4	1.4	1.5	-1.3	-1.2	1.2
Time in familiar zone, hab. session 2	5.7	5.9	6.7	-2.4	-2.5	2.5	2.4	-2.6	-2.6	-1.9
Time in novel zone, hab. session 2	6.3	6.3	7.3	2.4	2.6	-2.6	-2.4	2.7	2.7	2.1
Total zone transitions, hab. session 2	1.1	1.4	4.5	0.7	1.0	-0.9	-0.8	1.1	1.1	2.1
Total locomotion distance, hab. session 2	0.2	0.3	1.3	-0.6	-0.4	0.3	0.4	-0.3	-0.3	1.1
Locomotion velocity, hab. session 2	0.3	0.4	2.1	-0.6	-0.4	0.3	0.4	-0.3	-0.3	1.4
Novel to familiar place preference ratio	3.7	3.9	4.4	1.8	2.0	-1.9	-1.8	2.1	2.1	2.1
Novelty place preference	2.5	2.6	3.6	1.4	1.6	-1.5	-1.4	1.7	1.7	1.9
Time in novel zone, NPP test	3.1	3.2	3.7	1.6	1.8	-1.7	-1.6	1.9	1.9	1.9
Total zone transitions, NPP test	0.6	0.9	1.5	0.7	0.8	-1.1	-1.0	0.9	0.9	1.2
Total locomotion distance, NPP test	0.3	0.5	2.0	0.2	0.4	-0.5	-0.4	0.5	0.5	1.4
Locomotion velocity, NPP test	0.2	0.2	1.5	-0.1	0.1	-0.2	-0.1	0.1	0.2	1.2
Intraocular pressure	0.6	0.9	2.6	-0.6	-0.8	0.6	0.5	-1.0	-1.0	-1.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1	0.2	0.2	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.6	0.2	0.3	-0.2	-0.1	0.3	0.3	0.8
Parametrial fat weight	0.1	0.1	0.3	-0.3	-0.4	0.3	0.2	-0.4	-0.4	-0.5
Pavlov. Cond. lever latency	0.2	0.2	1.5	0.2	0.0	-0.0	-0.1	-0.0	-0.1	-1.2
Pavlov. Cond. magazine entry latency	1.7	2.2	2.5	-1.5	-1.6	1.6	1.6	-1.6	-1.6	-0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	0.4	-0.3	-0.3	0.4	0.4	0.4
Pavlov. Cond. index score	0.3	0.4	0.6	-0.8	-0.7	0.6	0.7	-0.6	-0.6	0.6
Pavlov. Cond. latency score	0.4	0.5	0.8	-0.8	-0.6	0.6	0.7	-0.6	-0.5	0.9
Pavlov. Cond. lever contacts	0.3	0.4	2.4	-0.1	0.1	-0.3	-0.1	0.2	0.3	1.6
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	0.9	0.9	-0.8	-0.8	0.9	0.9	0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.1	-0.2	-0.3	0.4	0.3	-0.4	-0.4	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.9	-0.8	0.8	0.9	-0.7	-0.7	0.5
Pavlov. Cond. response bias	0.6	0.8	1.0	-1.0	-1.0	0.9	0.9	-1.0	-0.9	-0.2
Pavlov. Cond. lever latency	1.4	1.9	2.4	1.6	1.5	-1.3	-1.3	1.5	1.5	0.5
Pavlov. Cond. magazine entry latency	2.2	2.6	3.3	-1.8	-1.8	1.6	1.7	-1.7	-1.7	-0.4
Pavlov. Cond. change in total contacts	0.8	1.1	1.3	-1.1	-1.1	1.1	1.1	-1.1	-1.1	-0.5
Pavlov. Cond. index score	2.1	2.7	3.2	-1.8	-1.8	1.7	1.7	-1.8	-1.8	-0.7
Pavlov. Cond. latency score	2.0	2.5	3.2	-1.8	-1.8	1.6	1.6	-1.7	-1.7	-0.4
Pavlov. Cond. lever contacts	1.4	1.9	2.3	-1.4	-1.5	1.4	1.3	-1.5	-1.5	-0.9
Pavlov. Cond. magazine entry number	2.1	2.6	3.2	1.8	1.7	-1.7	-1.7	1.7	1.7	0.4
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.4	1.2	1.1	-1.1	-1.2	1.0	1.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	3.4	-1.8	-1.8	1.8	1.8	-1.8	-1.8	-0.6
Pavlov. Cond. response bias	2.3	3.1	3.7	-1.8	-1.9	1.8	1.8	-1.9	-1.9	-1.0
Time in closed arm before self-admin	0.5	0.6	2.1	0.4	0.6	-0.7	-0.6	0.6	0.7	1.4
Time in closed arm after self-admin	0.1	0.2	0.2	0.5	0.5	-0.2	-0.3	0.5	0.5	0.2
Time in open arm before self-admin	0.8	0.9	1.6	-0.7	-0.8	1.3	1.2	-0.8	-0.8	-0.9
Time in open arm after self-admin	1.0	1.1	1.5	1.2	1.1	-1.2	-1.2	1.1	1.0	-0.1
Bone: periosteal estimation	1.2	2.6	5.2	1.3	1.6	-1.2	-1.1	1.7	1.7	2.3
Bone: periosteal perimeter	0.3	0.5	2.9	-0.0	0.2	0.0	0.2	0.4	0.4	1.7
Bone: post-yield work	0.3	0.5	0.6	0.8	0.8	-0.7	-0.7	0.8	0.8	0.3
Progressive ratio test 1 active lever presses	1.2	1.2	1.5	1.2	1.2	-1.1	-1.1	1.2	1.2	0.3
Progressive ratio test 1 breakpoint	1.3	1.4	1.6	1.3	1.3	-1.2	-1.2	1.3	1.3	0.4
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.6	-0.2	-0.2	0.7	0.7	-0.1	-0.1	0.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	0.7	0.7	-0.5	-0.5	0.7	0.7	0.4
Progressive ratio test 2 breakpoint	0.1	0.2	0.6	0.3	0.4	-0.1	-0.0	0.4	0.4	0.7
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.4	0.4	0.5	-0.1	-0.1	0.6	0.5	0.7
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.4	-0.4	0.6	0.6	-0.4	-0.4	-0.1
Incentive Sensitization - Breakpoint	0.2	0.3	0.5	-0.5	-0.4	0.7	0.7	-0.4	-0.4	0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.6	-0.6	0.6	0.5	-0.6	-0.6	-0.4
Progressive ratio	0.9	1.0	1.5	1.2	1.2	-1.0	-1.0	1.1	1.1	0.0
Food seeking constrained by brief footshock	1.3	1.7	2.2	-1.4	-1.5	1.2	1.2	-1.5	-1.5	-0.6
Seeking ratio, punishment vs. effort	2.0	2.4	3.1	-1.7	-1.7	1.4	1.5	-1.8	-1.7	-0.6
Retroperitoneal fat weight	2.3	7.4	9.3	3.0	2.9	-2.9	-3.0	2.9	2.9	0.5
Reaction time number correct	0.8	1.1	1.6	1.2	1.1	-1.1	-1.3	1.0	1.0	-0.7
Reaction time mean minus median	1.2	1.6	2.0	-1.4	-1.4	1.3	1.3	-1.4	-1.4	-0.3
Reaction time mean minus median AUC	1.0	1.3	2.1	-1.4	-1.2	1.0	1.2	-1.1	-1.1	1.1
Reaction time num false alarms	0.6	0.8	1.1	1.0	0.9	-1.0	-1.0	0.9	0.9	-0.0
Reaction time num false alarms AUC	0.6	0.9	1.2	1.1	1.0	-1.0	-1.1	0.9	0.9	-0.4
Reaction time trials correct on left	0.8	1.1	1.6	1.2	1.1	-1.1	-1.3	1.0	1.0	-0.7
Reaction time trials on left	0.8	1.1	1.5	1.2	1.1	-1.1	-1.2	1.0	1.0	-0.6
Reaction time mean	0.8	1.2	1.8	-1.3	-1.2	1.0	1.1	-1.1	-1.1	0.6
Reaction time mean AUC	0.4	0.5	0.7	-0.9	-0.7	0.6	0.7	-0.6	-0.6	0.8
Median of all reaction times	0.4	0.5	0.8	-0.9	-0.8	0.6	0.7	-0.7	-0.7	0.7
Reaction time omissions	0.0	0.0	0.2	-0.1	0.0	0.1	0.2	0.1	0.1	0.5
Reaction time false alarm rate	0.1	0.2	0.3	0.4	0.5	-0.5	-0.5	0.5	0.5	0.3
Reaction time premature initiation rate	1.7	2.3	2.6	-1.4	-1.5	1.5	1.4	-1.6	-1.6	-1.6
Reaction time premature initiations	1.0	1.4	4.2	-0.7	-1.0	1.0	0.8	-1.1	-1.1	-2.0
Std. dev. reaction times	0.6	0.8	1.3	-1.1	-1.0	0.8	0.9	-1.0	-1.0	0.4
Reaction time trials completed	0.8	1.1	1.5	1.2	1.1	-1.1	-1.2	1.0	1.0	-0.6
Reaction time trials AUC	0.9	1.2	1.7	1.3	1.1	-1.2	-1.3	1.0	1.0	-0.8
Run reversals in cocaine runway, females	1.5	1.5	2.1	-1.4	-1.3	1.2	1.3	-1.3	-1.3	0.1
Run reversals in cocaine runway, males	2.4	2.3	3.2	-1.7	-1.6	1.7	1.8	-1.5	-1.5	0.2
Latency to leave start box in cocaine runway	0.7	0.7	2.9	0.3	0.5	-0.7	-0.5	0.6	0.7	1.7
Latency to leave start box in cocaine runway, F	1.2	1.3	5.8	0.4	0.7	-0.9	-0.6	0.9	0.9	2.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.9	0.1	-0.0	-0.0	-0.1	-0.1	-0.1	-1.0
Std. dev. time between licks in bursts	0.6	0.7	1.3	-0.8	-0.7	1.0	1.1	-0.6	-0.5	0.9
Total sessions with >9 infusions	0.5	0.6	2.7	0.3	0.5	-0.0	0.1	0.7	0.7	1.6
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.0	-0.0	0.3	0.3	0.0	0.0	0.1
Short access day 10 total inactive lever presses	0.2	0.3	1.1	-0.1	-0.2	0.7	0.5	-0.2	-0.3	-1.0
Short access day 1 total infusions	1.1	1.1	3.4	0.8	1.0	-0.4	-0.3	1.2	1.2	1.8
Short access day 10 total infusions	0.5	0.6	0.9	0.8	0.9	-0.6	-0.6	0.9	0.9	0.6
Short access total infusions	1.7	1.9	2.9	1.3	1.5	-1.0	-0.9	1.6	1.6	1.7
Short access day 1 locomotion	0.1	0.1	0.4	-0.3	-0.2	0.4	0.5	-0.1	-0.1	0.6
Short access day 10 total locomotion	2.7	3.0	4.5	-1.6	-1.7	2.1	2.0	-1.6	-1.7	-1.3
Short access total locomotion	0.3	0.3	0.6	-0.6	-0.5	0.7	0.8	-0.4	-0.4	0.1
One hour access (0.3 mA shock)	0.3	0.4	0.5	0.7	0.7	-0.6	-0.6	0.7	0.7	0.2
Compulsive drug intake	0.4	0.4	0.6	0.5	0.6	-0.8	-0.7	0.5	0.6	0.4
One hour access (shock baseline)	0.1	0.1	0.3	0.2	0.1	0.2	0.1	0.1	0.1	-0.6
Social response proportion	0.5	0.6	0.9	-1.0	-0.9	0.7	0.7	-0.8	-0.8	0.3
Social responses	7.6	9.7	12.8	-3.6	-3.4	3.2	3.3	-3.3	-3.3	-0.2
Social time	1.1	1.4	1.8	1.4	1.3	-1.2	-1.3	1.2	1.2	0.1
Soleus weight	6.5	18.9	22.4	4.7	4.6	-4.7	-4.7	4.6	4.6	1.4
Bone: stiffness	4.8	7.7	9.0	2.8	3.0	-2.8	-2.7	3.0	3.0	1.9
Tibialis anterior weight	1.4	4.7	5.9	2.3	2.3	-2.4	-2.4	2.2	2.2	0.8
Time to tail flick, vehicle, before self-admin	1.7	1.8	3.1	-1.4	-1.1	1.6	1.8	-1.0	-1.0	1.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.4	-0.5	-0.6	0.5	0.4	-0.7	-0.7	-1.2
Time to tail flick, test, before self-admin	0.8	0.8	1.1	-1.0	-0.8	0.8	1.0	-0.7	-0.7	1.0
Time to tail flick, test, after self-admin	0.2	0.2	1.1	-0.3	-0.1	0.2	0.3	-0.0	-0.0	1.1
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.5	1.1	0.8	-1.4	-1.6	0.7	0.7	-1.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.2	-0.3	0.2	0.1	-0.4	-0.4	-0.9
Tibia length	0.9	2.6	3.3	-1.7	-1.8	1.6	1.5	-1.8	-1.8	-1.0
Ambulatory time before self-admin	0.3	0.3	0.3	-0.6	-0.5	0.6	0.6	-0.5	-0.5	-0.1
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3	-0.1	-0.1	0.2
Bone: tissue strength	4.3	4.2	5.0	2.1	2.2	-2.0	-2.0	2.2	2.2	1.3
Total heroin consumption	2.0	2.3	3.1	-1.8	-1.7	1.5	1.6	-1.7	-1.6	-0.2
Bone: trabecular number	0.5	0.7	2.1	-1.0	-0.7	0.5	0.7	-0.6	-0.6	1.4
Bone: trabecular spacing	0.7	0.9	5.9	0.5	0.1	0.0	-0.3	-0.1	-0.1	-2.4
Bone: trabecular thickness	1.8	2.2	12.8	0.1	0.7	-0.6	-0.2	0.9	0.9	3.6
Bone: trabecular tissue density	5.0	7.0	9.2	3.0	2.9	-2.8	-2.9	2.8	2.8	0.1
Water consumed over 24 hours	1.1	1.3	2.3	1.0	1.1	-0.9	-0.8	1.2	1.2	1.5
Number of responses in last shaping day	1.4	1.5	2.6	-1.2	-1.2	1.6	1.6	-1.1	-1.1	-0.4