Xrcc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Xrcc3	0.13	0.1	1.5e-03	0.09	0.1	0.09	0.09	3.2e-03	2.2e-03	4.4e-03	4.3e-03
2	PL	mRNA stability	Xrcc3	0.04	0.03	2.2e-06	0.05	0.06	0.05	0.05	1.5e-06	9.4e-07	3.9e-06	1.8e-06
3	Adipose	gene expression	Xrcc3	0.33	0.15	0.0e+00	0.26	0.27	0.27	0.27	2.0e-28	6.7e-30	2.3e-30	4.7e-30
4	Adipose	mRNA stability	Xrcc3	0.3	0.18	3.5e-15	0.11	0.1	0.11	0.11	2.0e-12	1.4e-11	6.6e-12	2.7e-12
5	LHb	mRNA stability	Xrcc3	0.2	0.21	8.2e-03	0.08	0.08	0.07	0.07	6.3e-03	7.0e-03	9.7e-03	8.8e-03
6	NAcc	mRNA stability	Xrcc3	0.06	0.04	2.1e-09	0.08	0.08	0.08	0.08	1.5e-09	7.1e-10	1.1e-09	1.2e-09
7	Brain	mRNA stability	Xrcc3	0.07	0.06	6.0e-06	0.05	0.05	0.05	0.05	1.0e-05	8.4e-06	2.0e-05	9.4e-06
8	BLA	mRNA stability	Xrcc3	0.21	0.13	1.4e-08	0.13	0.14	0.14	0.14	3.1e-07	8.3e-08	7.0e-08	5.8e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.1	0.2	-0.2	0.2	-0.3	-0.4	-0.3	0.2	0.2	0.2
Area under the delay curve	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.2	-0.2	0.3	0.3	0.2
BMI with tail	2.5	7.9	8.7	-2.9	2.9	-2.8	-2.5	-2.7	2.9	2.9	2.8
BMI without tail	0.6	1.3	1.6	-1.2	1.2	-1.1	-0.6	-1.2	1.2	1.2	1.3
Body weight	0.2	0.7	1.3	0.9	-0.9	0.9	1.1	0.8	-0.7	-0.6	-0.7
Weight adjusted by age	0.0	0.0	0.1	0.3	-0.2	0.2	0.0	0.1	-0.1	-0.1	-0.1
Bone surface	0.0	0.1	0.2	-0.2	0.2	-0.3	-0.4	-0.3	0.2	0.2	0.3
Bone volume	0.0	0.1	0.1	-0.2	0.2	-0.3	-0.3	-0.3	0.2	0.2	0.3
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.3	-0.1	0.1	0.1	-0.2
Number of licking bursts	0.0	0.0	0.1	0.1	-0.1	0.1	0.1	0.2	-0.2	-0.3	-0.1
Context. condit. distance diff. score	2.2	2.7	3.5	1.8	-1.7	1.7	1.9	1.4	-1.6	-1.5	-1.5
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	-0.5	0.4	0.4	0.3	-0.5	-0.5	-0.4
Locomotion distance, session 1	0.5	0.6	0.9	-0.7	0.8	-0.8	-0.9	-0.9	0.7	0.6	0.7
Locomotion velocity, session 2	0.0	0.0	0.0	-0.0	-0.0	0.2	0.2	0.1	-0.0	0.0	-0.1
Locomotion distance, session 2	0.3	0.5	0.5	-0.6	0.7	-0.7	-0.7	-0.7	0.7	0.6	0.7
Locomotion velocity, session 3	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4	-0.4	0.4	0.4	0.3
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1	0.0	-0.0	0.1	-0.1	-0.1	-0.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	-0.3	0.4	0.4	0.4	-0.4	-0.4	-0.4
Stereotopy head waving duration, day 3	0.2	0.3	0.4	0.5	-0.5	0.5	0.6	0.5	-0.5	-0.5	-0.5
Locomotion velocity, session 7	0.2	0.2	0.4	-0.5	0.5	-0.5	-0.7	-0.4	0.5	0.5	0.4
Locomotion distance, session 7	0.8	1.0	1.0	-1.0	1.0	-1.0	-1.0	-1.0	1.0	1.0	1.0
Stereotopy head waving bouts, day 7	1.0	1.2	1.3	1.1	-1.1	1.1	1.0	1.0	-1.1	-1.1	-1.1
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.7	-0.7	0.7	0.6	0.6	-0.7	-0.6	-0.7
Locomotion velocity, session 8	0.3	0.4	0.6	0.7	-0.6	0.6	0.8	0.5	-0.5	-0.4	-0.5
Locomotion distance, session 8	0.0	0.0	0.1	0.2	-0.1	-0.0	0.3	-0.2	0.1	0.1	0.2
Degree of sensitization distance	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.4	-0.3	0.3	0.3	0.3
Degree of sensitization stereotypy	0.2	0.2	0.2	0.5	-0.5	0.4	0.2	0.4	-0.5	-0.5	-0.5
Conditioned locomotion	1.3	1.6	1.6	1.3	-1.3	1.2	1.3	1.2	-1.3	-1.2	-1.2
Cocaine response after cond. corrected	0.7	0.7	1.3	-0.9	0.9	-0.9	-0.7	-0.8	0.8	0.7	1.1
Cocaine response after cond. not corrected	2.0	2.2	2.5	-1.6	1.5	-1.5	-1.3	-1.4	1.5	1.4	1.4
Cocaine response before conditioning	2.0	2.5	3.0	-1.6	1.7	-1.5	-1.7	-1.7	1.7	1.7	0.7
Saline control response	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.4	-0.5	0.5	0.5	-0.4
Bone: connectivity density	0.0	0.1	0.2	0.4	-0.4	0.2	0.1	0.2	-0.3	-0.2	-0.3
Bone: cortical apparent density	8.8	11.6	12.1	3.3	-3.4	3.5	3.3	3.4	-3.4	-3.4	-3.5
Bone: cortical area	0.8	1.3	1.7	1.0	-1.0	1.0	1.2	1.1	-1.1	-1.3	-1.1
Bone: cortical porosity	0.0	0.0	0.1	0.3	-0.2	0.1	0.1	0.0	-0.1	-0.0	-0.0
Bone: cortical porosity	0.2	0.2	0.3	-0.2	0.3	-0.5	-0.4	-0.6	0.4	0.5	0.5
Bone: cortical thickness	0.7	1.2	1.8	1.0	-1.0	1.0	1.0	1.1	-1.2	-1.3	-1.1
Bone: cortical thickness	0.7	0.8	1.0	1.0	-0.9	0.8	0.9	0.9	-0.9	-1.0	-0.8
Bone: cortical tissue density	9.0	11.8	12.3	3.3	-3.4	3.5	3.4	3.5	-3.5	-3.4	-3.5
Condit. Reinf. active minus inactive responses	0.6	0.6	0.7	-0.8	0.8	-0.8	-0.7	-0.8	0.8	0.8	0.8
Condit. Reinf. active-inactive response ratio	2.7	2.9	3.2	-1.7	1.7	-1.8	-1.8	-1.7	1.7	1.6	1.7
Condit. Reinf. active responses	0.1	0.2	0.2	-0.5	0.5	-0.4	-0.2	-0.5	0.4	0.4	0.4
Condit. Reinf. inactive responses	1.9	2.2	2.7	1.4	-1.5	1.6	1.6	1.4	-1.5	-1.5	-1.5
Incentive salience index mean	0.5	0.6	0.7	-0.8	0.8	-0.8	-0.8	-0.8	0.8	0.7	0.8
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.4	0.4	-0.4	-0.5	-0.4	0.4	0.3	0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.2	0.9	-0.8	0.8	1.1	0.7	-0.7	-0.6	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.3	0.8	-0.8	0.7	1.1	0.7	-0.7	-0.6	0.4
Condit. Reinf. active responses	0.0	0.0	0.2	0.1	-0.1	0.2	0.5	-0.0	-0.0	0.1	-0.1
Condit. Reinf. inactive responses	0.5	0.6	0.8	-0.9	0.9	-0.6	-0.6	-0.8	0.9	0.9	-0.3
Condit. Reinf. lever presses	1.2	1.7	2.3	-1.3	1.4	-1.2	-0.9	-1.5	1.5	1.5	0.8
Condit. Reinf. lever reinforcers received	0.0	0.1	0.3	0.1	-0.1	0.2	0.6	-0.0	0.0	0.1	-0.0
Conditioned reinforcement - actives	2.3	2.3	2.8	1.5	-1.5	1.6	1.7	1.5	-1.5	-1.5	-1.6
Conditioned reinforcement - inactives	0.4	0.5	0.7	0.6	-0.6	0.7	0.8	0.6	-0.6	-0.6	-0.8
Conditioned locomotion	0.5	0.6	0.9	-0.8	0.8	-0.8	-0.7	-0.9	0.9	0.9	0.4
Patch foraging indifference point 0 sec	3.7	6.0	6.5	2.4	-2.5	2.5	2.5	2.5	-2.4	-2.3	-2.5
Patch foraging indifference point AUC	2.6	3.0	3.4	1.7	-1.7	1.7	1.6	1.8	-1.8	-1.8	-1.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	-0.4	0.4	0.5	0.3	-0.3	-0.3	-0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.2	0.2	-0.1	0.3	-0.1	0.2	0.2	0.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.4	0.4	-0.5	-0.8	-0.3	0.3	0.2	0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	-0.3	0.3	-0.4	-0.8	-0.3	0.3	0.2	0.3
Delay disc. indifference point, 4s delay	0.1	0.2	0.2	0.4	-0.4	0.4	0.4	0.4	-0.4	-0.3	-0.4
Delay disc. indifference point, 8s delay	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.3	-0.3	0.4	0.5	0.4
Indifference point function ln k	0.6	0.8	1.1	1.1	-1.0	0.9	0.9	0.8	-0.9	-0.8	-0.8
Indifference point function log k	0.6	0.8	1.1	1.1	-1.0	0.9	0.9	0.8	-0.9	-0.8	-0.8
Patch foraging total patch changes 0 sec	4.2	6.8	7.3	2.6	-2.6	2.7	2.7	2.6	-2.6	-2.4	-2.6
Patch foraging total patch changes 12 sec	4.0	5.2	5.7	2.2	-2.3	2.3	2.2	2.4	-2.3	-2.2	-2.4
Patch foraging total patch changes 18 sec	1.7	2.2	2.7	1.3	-1.4	1.5	1.4	1.6	-1.5	-1.4	-1.7
Patch foraging total patch changes 24 sec	0.2	0.3	0.4	0.4	-0.5	0.5	0.5	0.6	-0.5	-0.4	-0.6
Patch foraging total patch changes 6 sec	2.4	3.5	5.2	1.7	-1.8	2.0	2.3	1.9	-1.8	-1.7	-1.9
Patch foraging time to switch 0 sec	11.5	17.7	17.8	-4.2	4.2	-4.2	-4.2	-4.2	4.2	4.2	4.2
Patch foraging water rate 0 sec	19.9	31.9	32.7	5.6	-5.6	5.7	5.7	5.7	-5.7	-5.6	-5.6
Patch foraging water rate 12 sec	10.1	15.5	18.2	4.0	-3.9	4.0	4.3	3.8	-3.9	-3.8	-3.8
Patch foraging water rate 18 sec	5.0	6.8	7.3	2.7	-2.7	2.6	2.5	2.6	-2.7	-2.6	-2.6
Patch foraging water rate 24 sec	4.1	5.7	6.2	2.5	-2.4	2.4	2.4	2.4	-2.4	-2.4	-2.3
Patch foraging water rate 6 sec	5.2	7.6	8.9	2.7	-2.7	2.8	3.0	2.8	-2.7	-2.6	-2.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	0.6	-0.5	0.5	0.2	0.5	-0.5	-0.6	-0.5
Distance traveled before self-admin	0.1	0.1	0.1	-0.4	0.3	-0.3	-0.3	-0.1	0.2	0.1	0.1
Distance traveled after self-admin	0.5	0.5	0.9	0.7	-0.7	0.7	0.9	0.7	-0.7	-0.7	-0.7
Extensor digitorum longus weight	6.2	24.4	26.8	5.2	-5.1	5.0	5.1	4.8	-4.9	-4.8	-4.8
Bone: elastic displacement	0.5	0.6	0.7	0.8	-0.8	0.8	0.5	0.8	-0.8	-0.9	-0.8
Bone: elastic work	0.1	0.1	0.2	0.4	-0.3	0.3	0.2	0.3	-0.3	-0.4	-0.3
Bone: endosteal estimation	0.2	0.4	0.6	-0.5	0.6	-0.6	-0.3	-0.7	0.7	0.7	0.7
Bone: endosteal perimeter	0.0	0.0	0.1	-0.1	0.1	-0.1	0.3	-0.1	0.1	0.1	0.2
Epididymis fat weight	4.4	10.3	10.7	-3.3	3.3	-3.2	-3.1	-3.1	3.3	3.3	3.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	0.2	-0.2	-0.0	-0.3	0.2	0.2	0.4
Delta time in open arm before/after self-admin	0.7	0.7	2.7	0.6	-0.6	0.8	0.6	0.7	-0.6	-0.7	-1.6
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	-0.0	0.1	0.0	0.2	-0.1	-0.2	-0.0
Delay discount exponential model param	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	0.1	-0.2	-0.2	-0.2
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	-0.1	0.1	0.0	0.0
Active lever presses in extinction session 6	1.4	1.4	1.6	1.3	-1.2	1.2	1.2	1.1	-1.1	-1.1	-1.2
Bone: final force	0.3	0.4	0.5	0.7	-0.6	0.6	0.7	0.5	-0.6	-0.7	-0.5
Bone: final moment	0.3	0.5	0.6	0.8	-0.7	0.7	0.8	0.6	-0.7	-0.8	-0.6
Food consumed during 24 hour testing period	0.2	0.3	0.9	0.5	-0.4	0.5	0.7	0.3	-0.4	-0.4	-1.0
Glucose	0.8	1.2	1.5	0.9	-1.0	1.1	1.0	1.2	-1.1	-1.2	-1.2
Heart weight	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.1	0.1
Delay discount hyperbolic model param	0.1	0.1	0.1	0.3	-0.2	0.3	0.3	0.2	-0.2	-0.3	-0.2
Intermittent access intake day 1-15 change	1.3	1.3	1.6	-1.3	1.2	-1.1	-1.1	-1.2	1.2	1.1	0.8
Intermittent access intake escalation	1.5	1.5	1.7	-1.3	1.3	-1.2	-1.2	-1.3	1.3	1.2	1.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.5	0.4	-0.4	-0.4	-0.4	0.4	0.3	0.1
Intermitt. access day 1 inactive lever presses	2.8	3.0	3.4	1.8	-1.8	1.8	1.8	1.8	-1.8	-1.7	-1.5
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.3	1.0	-1.0	1.0	1.2	1.0	-1.0	-1.0	-0.8
Intermitt. access escalation Index	0.3	0.3	0.4	0.5	-0.6	0.5	0.6	0.6	-0.6	-0.5	-0.1
Intermittent access day 1 total infusions	0.3	0.4	0.5	-0.6	0.6	-0.6	-0.4	-0.6	0.7	0.7	0.6
Intermittent access day 15 total infusions	1.7	1.9	2.2	-1.5	1.5	-1.4	-1.2	-1.4	1.4	1.4	1.2
Intermittent access terminal intake (last 3 days)	1.9	2.1	2.7	-1.6	1.6	-1.4	-1.3	-1.5	1.5	1.5	0.9
Intermittent access total infusions	0.6	0.7	0.9	-0.9	0.9	-0.8	-0.6	-0.8	0.9	0.9	0.8
Intermittent access day 1 locomotion	0.7	0.7	1.0	-0.9	0.9	-0.8	-0.8	-1.0	1.0	1.0	0.3
Intermittent access day 15 total locomotion	0.3	0.3	0.4	-0.5	0.5	-0.5	-0.4	-0.6	0.6	0.6	0.3
Intermittent access total locomotion	0.4	0.4	0.5	-0.7	0.7	-0.6	-0.5	-0.7	0.7	0.7	0.3
Intermittent access standard deviation	3.4	3.6	4.2	-2.0	2.0	-1.8	-1.8	-2.0	2.0	1.9	1.4
Left kidney weight	0.8	2.4	2.9	1.7	-1.6	1.7	1.7	1.5	-1.5	-1.3	-1.4
Right kidney weight	0.4	1.2	1.7	1.3	-1.2	1.2	1.3	0.9	-1.0	-0.8	-0.9
Cocaine induced anxiety	2.8	3.3	3.5	1.8	-1.8	1.8	1.8	1.9	-1.8	-1.9	-1.7
Post-drug Anxiety	2.4	2.7	3.0	1.5	-1.6	1.7	1.7	1.7	-1.6	-1.7	-1.6
Baseline Anxiety	1.5	1.6	1.9	-1.4	1.3	-1.3	-1.1	-1.3	1.3	1.3	1.1
Tail length	3.4	10.3	12.9	3.4	-3.3	3.3	3.6	3.0	-3.1	-3.0	-3.0
Length with tail	4.7	17.3	19.0	4.4	-4.3	4.3	4.3	4.0	-4.1	-3.9	-4.0
Length without tail	2.2	4.8	5.3	2.3	-2.3	2.3	1.9	2.2	-2.2	-2.0	-2.2
Times rat made contact with spout	0.4	0.4	0.9	0.5	-0.5	0.7	0.6	0.7	-0.6	-0.6	-0.9
Lifetime Intake	0.2	0.3	0.4	-0.6	0.6	-0.4	-0.3	-0.5	0.6	0.6	0.3
Liver weight, left	3.0	4.8	5.2	2.2	-2.1	2.2	2.2	2.2	-2.2	-2.3	-2.2
Liver weight, right	0.0	0.0	0.0	0.1	-0.1	0.0	0.1	0.1	-0.1	-0.1	-0.1
Locomotor activity	0.1	0.2	0.2	0.4	-0.4	0.4	0.4	0.4	-0.4	-0.3	-0.4
Locomotor testing distance	0.4	0.6	0.7	0.8	-0.8	0.8	0.8	0.9	-0.8	-0.7	-0.8
Locomotor testing rearing	1.2	1.8	2.3	-1.5	1.4	-1.4	-1.3	-1.2	1.3	1.4	1.2
Locomotion in novel chamber	5.7	7.0	7.5	2.7	-2.7	2.7	2.7	2.6	-2.6	-2.5	-2.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.0	-0.5	0.3	0.3	0.4
Fecal boli incidents, locomotor time 1	2.4	2.6	3.4	-1.5	1.6	-1.7	-1.8	-1.6	1.5	1.4	1.5
Change in fecal boli incidents, locomotor task	0.7	0.7	2.0	0.9	-0.8	0.9	1.4	0.6	-0.6	-0.4	-0.5
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.5	-0.6	0.6	-0.5	-0.3	-0.7	0.7	0.7	0.7
Bouts of movement, locomotor time 1	1.6	1.8	3.0	-1.3	1.3	-1.5	-1.7	-1.2	1.2	1.1	1.2
Total resting periods, locomotor time 1	1.5	1.7	2.6	-1.3	1.3	-1.4	-1.6	-1.2	1.2	1.1	1.2
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	-0.3	0.2	-0.0	0.5	-0.4	-0.5	-0.5
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.4	0.4	-0.3	-0.5	-0.4	0.5	0.6	0.5
Vertical activity count, locomotor time 1	0.6	0.6	0.8	0.8	-0.8	0.8	0.6	0.9	-0.8	-0.8	-0.8
Time >=10cm from walls, locomotor time 2	0.6	0.6	0.7	0.8	-0.8	0.7	0.6	0.7	-0.8	-0.8	-0.8
Bouts of movement, locomotor time 2	1.9	2.0	2.2	1.5	-1.4	1.3	1.4	1.3	-1.4	-1.5	-1.4
Total resting periods, locomotor time 2	1.4	1.5	1.7	1.3	-1.2	1.2	1.3	1.2	-1.2	-1.3	-1.2
Rest time, locomotor task time 2	0.2	0.3	0.3	0.5	-0.5	0.5	0.6	0.6	-0.5	-0.6	-0.5
Distance moved, locomotor task time 2	0.2	0.2	0.6	-0.5	0.4	-0.4	-0.7	-0.3	0.4	0.4	0.3
Vertical activity count, locomotor time 2	0.4	0.5	0.7	0.6	-0.7	0.6	0.2	0.8	-0.7	-0.8	-0.8
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1	-0.0	0.1	0.1	0.1
Light reinforcement 2	1.7	2.3	2.6	-1.6	1.6	-1.6	-1.2	-1.6	1.5	1.4	1.6
Bone: marrow area	0.1	0.3	0.5	-0.4	0.5	-0.6	-0.3	-0.6	0.6	0.6	0.7
Bone: maximum diameter	0.0	0.0	0.1	-0.0	-0.0	0.0	0.2	0.2	-0.2	-0.3	-0.1
Bone: maximum force	0.3	0.4	0.6	0.7	-0.7	0.6	0.7	0.6	-0.7	-0.8	-0.6
Bone: maximum moment	0.2	0.4	0.5	0.7	-0.6	0.6	0.7	0.5	-0.6	-0.7	-0.5
Mean time between licks in bursts	0.7	1.0	1.5	-1.0	1.1	-1.0	-0.6	-1.2	1.1	1.2	0.8
Mean num. licks in bursts	0.0	0.0	0.1	0.1	-0.1	0.2	0.3	0.1	-0.1	-0.1	-0.3
Cd content in liver	0.7	0.8	1.4	1.1	-0.9	0.8	1.0	0.6	-0.7	-0.6	-1.2
Co content in liver	0.9	1.1	1.7	1.1	-1.1	1.1	1.3	0.8	-1.0	-1.0	-0.8
Cu content in liver	1.0	1.3	1.7	-1.3	1.3	-1.1	-1.1	-1.1	1.2	1.1	0.8
Fe content in liver	0.2	0.2	0.6	-0.5	0.4	-0.5	-0.8	-0.4	0.4	0.3	0.3
K content in liver	0.1	0.1	0.2	0.3	-0.3	0.4	0.3	0.2	-0.3	-0.3	-0.4
Mg content in liver	0.1	0.1	0.5	0.3	-0.3	0.5	0.7	0.2	-0.3	-0.3	-0.1
Mn content in liver	0.1	0.1	0.3	0.4	-0.3	0.2	0.6	0.0	-0.2	-0.1	0.5
Na content in liver	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.4	-0.2	0.2	0.1	0.3
Rb content in liver	0.7	0.8	1.1	1.1	-1.0	1.0	1.1	0.8	-1.0	-0.9	-0.4
Se content in liver	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.4	-0.5	0.4	0.3	-0.3
Sr content in liver	0.4	0.4	0.9	0.6	-0.5	0.6	0.6	0.4	-0.5	-0.5	-1.0
Zn content in liver	0.2	0.2	0.5	0.4	-0.4	0.5	0.6	0.3	-0.4	-0.5	-0.7
Bone: minimum diameter	0.7	1.4	2.1	1.2	-1.2	1.2	1.4	1.1	-1.1	-1.1	-1.1
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.5	0.5	-0.5	-0.6	-0.5	0.6	0.7	0.5
Time in novel zone, hab. session 1	0.2	0.1	0.2	-0.4	0.4	-0.4	-0.4	-0.5	0.3	0.2	0.4
Total zone transitions, hab. session 1	0.5	0.7	1.0	-0.7	0.8	-0.9	-0.7	-1.0	0.9	0.9	1.0
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.4	-0.3	0.2	0.5	0.1	-0.2	-0.1	-0.1
Locomotion velocity, hab. session 1	0.5	0.7	1.2	1.0	-0.9	0.8	1.1	0.7	-0.8	-0.7	-0.7
Time in familiar zone, hab. session 2	0.4	0.4	0.6	-0.6	0.6	-0.6	-0.6	-0.5	0.6	0.8	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.2	0.3	-0.2	-0.1	-0.4	0.2	0.1	0.3
Total zone transitions, hab. session 2	0.8	1.0	1.1	-1.0	1.0	-1.1	-1.0	-1.1	1.0	0.9	1.0
Total locomotion distance, hab. session 2	0.3	0.4	0.5	0.7	-0.7	0.6	0.7	0.6	-0.7	-0.7	-0.6
Locomotion velocity, hab. session 2	0.5	0.7	0.8	0.8	-0.8	0.8	0.9	0.8	-0.8	-0.9	-0.8
Novel to familiar place preference ratio	0.5	0.5	0.8	-0.7	0.7	-0.7	-0.9	-0.6	0.6	0.6	0.7
Novelty place preference	0.3	0.3	0.5	-0.5	0.5	-0.6	-0.7	-0.5	0.5	0.4	0.5
Time in novel zone, NPP test	0.2	0.2	0.4	-0.4	0.5	-0.5	-0.6	-0.4	0.4	0.4	0.5
Total zone transitions, NPP test	0.1	0.2	0.3	-0.1	0.3	-0.5	-0.3	-0.6	0.4	0.4	0.5
Total locomotion distance, NPP test	0.0	0.0	0.1	0.3	-0.2	0.0	0.2	-0.0	-0.2	-0.2	-0.1
Locomotion velocity, NPP test	0.0	0.1	0.1	0.4	-0.3	0.1	0.3	0.0	-0.2	-0.2	-0.1
Intraocular pressure	0.1	0.1	0.3	-0.2	0.2	-0.4	-0.5	-0.2	0.3	0.3	0.3
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.3	-0.3	0.3	0.4	0.1	-0.2	-0.1	-0.5
Delta ambulatory time before/after self-admin	0.7	0.8	1.1	1.0	-0.9	1.0	1.0	0.7	-0.8	-0.7	-1.0
Parametrial fat weight	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	-0.1	0.1	0.0	0.1
Pavlov. Cond. lever latency	0.8	1.0	1.2	1.0	-1.0	1.0	1.1	0.9	-0.9	-0.9	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.7	1.4	-0.8	0.8	-0.9	-1.2	-0.7	0.8	0.8	0.7
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.6	0.5	-0.6	-0.6	-0.5	0.5	0.5	0.5
Pavlov. Cond. index score	1.1	1.4	2.0	-1.1	1.1	-1.3	-1.4	-1.1	1.1	1.1	1.1
Pavlov. Cond. latency score	0.7	0.9	1.4	-1.0	0.9	-1.1	-1.2	-0.8	0.9	0.9	0.9
Pavlov. Cond. lever contacts	1.0	1.2	1.6	-1.2	1.1	-1.1	-1.3	-1.0	1.0	1.0	1.0
Pavlov. Cond. magazine entry number	1.1	1.4	1.6	1.1	-1.1	1.2	1.3	1.1	-1.2	-1.2	-1.2
Pavlov. Cond. intertrial magazine entries	5.9	7.1	8.5	2.7	-2.7	2.7	2.9	2.5	-2.6	-2.6	-2.6
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.6	-1.0	1.0	-1.1	-1.3	-0.9	0.9	0.9	0.9
Pavlov. Cond. response bias	1.3	1.6	1.8	-1.2	1.2	-1.3	-1.3	-1.2	1.2	1.2	1.2
Pavlov. Cond. lever latency	1.9	2.5	3.4	1.6	-1.7	1.5	1.3	1.8	-1.7	-1.8	-1.3
Pavlov. Cond. magazine entry latency	4.6	5.3	6.1	-2.4	2.4	-2.3	-2.1	-2.5	2.4	2.5	1.8
Pavlov. Cond. change in total contacts	3.8	5.2	5.9	-2.4	2.4	-2.2	-2.1	-2.4	2.4	2.4	2.0
Pavlov. Cond. index score	4.6	5.9	7.0	-2.4	2.5	-2.3	-2.0	-2.7	2.6	2.6	2.1
Pavlov. Cond. latency score	4.6	5.7	6.6	-2.4	2.4	-2.3	-2.1	-2.6	2.5	2.6	2.2
Pavlov. Cond. lever contacts	2.7	3.6	4.8	-1.9	2.0	-1.8	-1.5	-2.2	2.1	2.1	1.5
Pavlov. Cond. magazine entry number	3.6	4.4	5.2	2.2	-2.2	2.0	1.7	2.2	-2.2	-2.3	-1.9
Pavlov. Cond. intertrial magazine entries	5.8	7.6	8.1	2.7	-2.7	2.8	2.7	2.8	-2.7	-2.7	-2.8
Pavlov. Cond. lever-magazine prob. diff.	5.0	6.4	7.6	-2.6	2.6	-2.4	-2.1	-2.8	2.7	2.8	2.2
Pavlov. Cond. response bias	3.4	4.7	6.1	-2.2	2.3	-2.0	-1.7	-2.5	2.4	2.4	1.7
Time in closed arm before self-admin	3.1	3.5	4.0	-2.0	2.0	-1.9	-2.0	-1.9	1.9	1.9	1.4
Time in closed arm after self-admin	1.5	1.6	1.8	-1.3	1.3	-1.3	-1.2	-1.3	1.3	1.3	0.9
Time in open arm before self-admin	5.2	5.6	6.8	2.5	-2.5	2.4	2.6	2.4	-2.5	-2.4	-1.4
Time in open arm after self-admin	3.6	3.9	4.2	2.0	-2.0	2.0	2.0	2.0	-2.0	-1.9	-2.0
Bone: periosteal estimation	0.1	0.1	0.4	0.4	-0.3	0.3	0.6	0.3	-0.3	-0.4	-0.2
Bone: periosteal perimeter	0.0	0.1	0.3	0.2	-0.1	0.2	0.6	0.2	-0.2	-0.3	-0.1
Bone: post-yield work	1.3	1.7	2.2	1.5	-1.4	1.3	1.2	1.3	-1.3	-1.2	-1.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.0	-0.1	0.1	0.1	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	0.3	-0.2	-0.2	-0.2	0.3	0.3	-0.2
Progressive ratio test 1 inactive lever presses	2.8	3.1	3.3	1.8	-1.8	1.8	1.8	1.8	-1.8	-1.8	-1.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.2	-0.1	0.1	-0.1	0.1	0.0	0.1	0.1	0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.0	0.0	0.0	0.2	0.0	0.0	0.1	0.3
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.5	1.0	-1.0	1.0	1.2	1.1	-1.0	-1.0	-0.7
Incentive Sensitization - Responses	0.1	0.1	0.5	-0.1	0.1	-0.1	0.0	-0.0	0.1	0.1	0.7
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.0	-0.0	-0.0	0.1	0.1	-0.0	0.0	0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.6	0.5	-0.4	-0.4	-0.4	0.4	0.4	0.4
Progressive ratio	0.5	0.5	1.1	0.7	-0.7	0.8	1.0	0.6	-0.7	-0.7	-0.6
Food seeking constrained by brief footshock	1.5	1.8	2.4	1.3	-1.3	1.2	1.1	1.5	-1.4	-1.5	-1.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.2	-0.3	0.1	-0.1	0.4	-0.3	-0.3	-0.3
Retroperitoneal fat weight	0.2	0.8	0.9	-0.9	0.9	-0.9	-0.8	-0.8	0.9	0.9	0.9
Reaction time number correct	3.3	4.8	5.4	2.1	-2.2	2.3	2.1	2.3	-2.2	-2.1	-2.2
Reaction time mean minus median	0.2	0.2	0.4	-0.4	0.4	-0.5	-0.6	-0.4	0.5	0.4	0.5
Reaction time mean minus median AUC	0.1	0.2	0.3	-0.3	0.4	-0.5	-0.5	-0.4	0.4	0.4	0.5
Reaction time num false alarms	1.0	1.4	1.6	1.1	-1.1	1.3	1.3	1.2	-1.1	-1.1	-1.2
Reaction time num false alarms AUC	1.5	2.1	2.4	1.4	-1.4	1.5	1.5	1.5	-1.4	-1.4	-1.4
Reaction time trials correct on left	3.3	4.8	5.4	2.1	-2.2	2.3	2.1	2.3	-2.2	-2.1	-2.2
Reaction time trials on left	3.3	4.7	5.3	2.1	-2.2	2.3	2.0	2.3	-2.2	-2.1	-2.2
Reaction time mean	1.0	1.4	1.6	-1.1	1.2	-1.2	-1.2	-1.3	1.2	1.2	1.2
Reaction time mean AUC	0.7	0.9	1.1	-0.9	0.9	-1.0	-0.9	-1.1	1.0	1.0	1.0
Median of all reaction times	0.6	0.8	1.1	-0.8	0.9	-0.9	-0.8	-1.0	0.9	0.9	0.9
Reaction time omissions	0.8	1.1	1.4	1.2	-1.1	1.0	0.7	1.0	-1.1	-1.1	-1.1
Reaction time false alarm rate	0.1	0.1	0.3	0.3	-0.3	0.4	0.5	0.3	-0.3	-0.3	-0.3
Reaction time premature initiation rate	0.8	1.1	1.4	1.0	-1.0	1.1	1.2	1.0	-1.0	-1.0	-1.0
Reaction time premature initiations	2.7	3.8	4.2	1.9	-1.9	2.1	2.0	2.0	-1.9	-1.9	-2.0
Std. dev. reaction times	0.5	0.7	0.8	-0.7	0.8	-0.9	-0.9	-0.8	0.8	0.8	0.8
Reaction time trials completed	3.3	4.7	5.3	2.1	-2.2	2.3	2.0	2.3	-2.2	-2.1	-2.2
Reaction time trials AUC	3.6	5.1	5.8	2.2	-2.3	2.4	2.1	2.4	-2.3	-2.2	-2.3
Run reversals in cocaine runway, females	1.2	1.2	1.8	-1.1	1.1	-1.1	-1.3	-0.9	1.1	1.1	1.0
Run reversals in cocaine runway, males	0.9	0.8	1.0	0.8	-0.9	0.8	0.9	1.0	-0.9	-1.0	-1.0
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.5	0.4	-0.1	0.0	-0.2	0.3	0.3	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.5	0.4	-0.2	-0.1	-0.1	0.3	0.3	0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.1	-0.4	0.3	0.3	0.3
Std. dev. time between licks in bursts	0.6	0.7	1.1	-0.6	0.7	-0.9	-0.5	-1.0	0.9	0.9	0.9
Total sessions with >9 infusions	0.0	0.0	0.0	-0.2	0.2	0.0	0.1	-0.1	0.2	0.2	-0.2
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.0	0.1	-0.1	0.0	-0.1	0.1	0.2	0.3
Short access day 10 total inactive lever presses	0.4	0.4	0.6	0.8	-0.7	0.6	0.7	0.7	-0.7	-0.6	-0.0
Short access day 1 total infusions	0.4	0.4	0.9	0.5	-0.5	0.7	0.8	0.5	-0.5	-0.5	-0.9
Short access day 10 total infusions	0.3	0.3	0.5	-0.7	0.7	-0.5	-0.5	-0.6	0.6	0.7	0.3
Short access total infusions	0.1	0.1	0.2	-0.5	0.5	-0.2	-0.1	-0.4	0.5	0.5	-0.2
Short access day 1 locomotion	0.4	0.5	0.7	-0.8	0.8	-0.5	-0.6	-0.7	0.8	0.9	0.0
Short access day 10 total locomotion	0.5	0.5	0.7	-0.9	0.8	-0.7	-0.7	-0.8	0.8	0.8	0.2
Short access total locomotion	0.1	0.1	0.3	-0.3	0.2	-0.0	-0.1	-0.2	0.2	0.3	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.4	0.3	-0.3	0.4	0.6	0.4	-0.3	-0.3	-0.4
Compulsive drug intake	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.1	-0.1	0.1	0.1	0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	0.0	0.1	-0.1	0.1	0.1	-0.1
Social response proportion	0.4	0.5	0.7	0.6	-0.6	0.8	0.9	0.7	-0.6	-0.5	-0.6
Social responses	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.1	-0.2	0.2	0.2	0.2
Social time	1.0	1.3	1.7	1.3	-1.2	1.2	1.2	1.0	-1.1	-1.0	-1.0
Soleus weight	0.0	0.0	0.0	0.1	-0.0	-0.1	0.0	-0.0	0.1	0.2	0.2
Bone: stiffness	1.5	2.4	2.9	1.6	-1.6	1.5	1.7	1.4	-1.6	-1.6	-1.5
Tibialis anterior weight	0.3	1.2	1.3	1.1	-1.1	1.1	1.1	1.1	-1.0	-1.0	-1.0
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.6	0.8	-0.8	0.5	0.5	0.7	-0.8	-0.8	0.7
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.6	-0.4	0.4	0.4	-0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.2	-0.2	0.2	0.3	0.3	-0.3	-0.3	0.1
Time to tail flick, test, after self-admin	1.5	1.6	1.8	1.4	-1.4	1.3	1.1	1.3	-1.3	-1.3	-0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.7	-0.2	0.2	0.0	-0.2	-0.2	0.2	0.3	-0.9
Delta time to tail flick, test, before/after SA	1.1	1.0	1.4	1.0	-1.0	1.0	0.8	0.8	-0.9	-0.9	-1.2
Tibia length	0.3	0.9	1.2	0.9	-0.9	0.9	0.7	1.0	-1.0	-1.1	-1.0
Ambulatory time before self-admin	0.1	0.1	0.3	-0.5	0.4	-0.4	-0.5	-0.2	0.3	0.2	0.0
Ambulatory time after self-admin	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	-0.1	0.1	0.1	-0.0
Bone: tissue strength	0.0	0.0	0.1	0.2	-0.2	0.1	-0.0	0.2	-0.2	-0.3	-0.2
Total heroin consumption	0.8	1.0	1.4	0.9	-1.0	0.9	1.0	1.1	-1.1	-1.2	-0.7
Bone: trabecular number	0.0	0.1	0.1	0.3	-0.3	0.2	0.1	0.2	-0.3	-0.2	-0.3
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.1	-0.3	0.3	0.2	0.3
Bone: trabecular thickness	0.1	0.1	0.1	0.3	-0.3	0.3	0.2	0.3	-0.3	-0.4	-0.4
Bone: trabecular tissue density	0.2	0.3	0.7	0.3	-0.5	0.6	0.3	0.8	-0.6	-0.6	-0.7
Water consumed over 24 hours	3.3	4.0	4.9	1.9	-2.0	2.0	2.2	2.0	-2.0	-2.0	-1.9
Number of responses in last shaping day	0.5	0.5	0.7	-0.7	0.7	-0.7	-0.7	-0.8	0.7	0.7	0.6