Hub : Genes

Wdr45b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio NM_001039587.1 0.03 0.02 3.9e-03 0.02 0.01 0.01 0.01 4.0e-04 4.1e-02 3.5e-02 8.4e-03
2 Adipose isoform ratio XM_039086444.2 0.07 0.04 1.2e-04 0.03 0.03 0.01 0.03 2.3e-04 1.6e-04 1.2e-02 2.8e-04
3 Liver isoform ratio NM_001039587.1 0.21 0.07 1.2e-13 0.1 0.1 0.11 0.11 5.3e-11 1.1e-11 4.9e-12 1.8e-12
4 Liver alternative polyA XM_039086444.2 0.15 0.06 7.7e-08 0.08 0.06 0.08 0.08 4.6e-09 3.4e-07 3.5e-09 2.9e-09
5 Liver isoform ratio XM_039086444.2 0.21 0.09 3.1e-11 0.09 0.09 0.1 0.1 2.0e-10 1.7e-10 4.1e-11 2.4e-11
6 NAcc gene expression Wdr45b 0.04 0.02 6.5e-05 0.02 0.02 0.01 0.01 5.2e-04 5.1e-04 7.8e-03 3.3e-03
7 Eye isoform ratio XM_039086444.2 0.24 0.13 9.9e-03 0.08 0.02 -0.02 0.01 2.5e-02 1.8e-01 9.5e-01 2.6e-01
8 Adipose alternative polyA XM_039086444.2 0.05 0.03 3.4e-04 0.02 0.03 0.03 0.03 4.2e-03 1.0e-04 5.1e-04 2.6e-04
9 Brain mRNA stability Wdr45b 0.04 0.02 7.9e-04 0.01 0.04 0.03 0.03 1.8e-02 2.9e-04 1.5e-03 1.8e-03
10 Liver mRNA stability Wdr45b 0.09 0.06 3.1e-03 0.03 0.02 0.01 0.02 3.2e-04 4.4e-03 1.6e-02 1.0e-03
11 PL mRNA stability Wdr45b 0.11 0.07 7.1e-05 0.04 0.03 0.05 0.02 5.6e-05 3.6e-04 3.2e-06 9.6e-04
12 Liver intron excision ratio chr10_107097846_107098802 0.1 0.07 5.4e-03 0 0.03 0.02 0.01 1.3e-01 4.7e-04 1.4e-03 4.4e-02
13 Adipose alternative polyA NM_001039587.1 0.23 0.1 5.9e-12 0.06 0.09 0.08 0.1 3.5e-07 2.4e-10 1.3e-09 5.1e-11
14 Adipose alternative polyA XM_039086444.2 0.24 0.1 5.8e-12 0.06 0.09 0.09 0.1 4.7e-07 2.9e-10 3.9e-10 7.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.31.6-0.3-0.50.5-0.4-0.60.7-0.0-0.50.3-0.6-0.61.30.10.1
Area under the delay curve0.50.72.80.2-0.0-0.30.30.2-0.51.70.2-1.41.41.6-0.20.30.1
BMI with tail0.41.65.12.21.5-1.61.61.30.1-0.70.3-0.02.20.3-1.00.6-0.8
BMI without tail0.31.53.2-0.6-0.50.8-0.8-1.11.5-1.1-1.81.5-0.5-1.61.21.3-1.7
Body weight0.41.94.52.11.8-1.61.61.2-0.1-1.8-0.31.80.9-0.9-0.61.1-1.6
Weight adjusted by age0.30.82.90.50.8-0.40.50.40.1-1.70.11.5-1.0-1.70.9-0.30.1
Bone surface0.30.62.2-0.7-0.50.9-0.9-0.80.3-0.5-0.50.7-1.5-1.11.10.4-0.4
Bone volume0.30.51.8-0.6-0.60.7-0.7-0.80.6-0.4-0.60.7-1.3-1.01.00.3-0.2
Breakpoint value in progressive ratio session0.71.34.61.21.4-1.21.31.4-2.2-0.90.60.40.30.6-1.70.2-0.6
Number of licking bursts0.20.51.2-0.8-0.90.9-0.9-1.01.10.5-0.8-0.0-0.4-0.50.60.4-0.3
Context. condit. distance diff. score2.42.84.9-2.2-2.02.1-2.2-2.12.10.9-2.0-0.1-0.9-0.61.21.6-1.6
Locomotion velocity, session 12.32.64.51.71.5-1.81.81.8-1.6-0.42.1-0.51.10.9-1.6-2.12.1
Locomotion distance, session 11.01.34.70.6-0.0-0.60.60.40.71.60.1-2.22.21.8-0.80.8-0.5
Locomotion velocity, session 21.31.64.90.80.5-0.90.91.1-1.01.31.0-2.01.92.2-1.4-0.10.4
Locomotion distance, session 20.40.61.90.4-0.1-0.30.30.00.71.1-0.5-1.21.41.00.00.8-0.8
Locomotion velocity, session 31.41.73.51.21.1-1.31.31.3-1.60.71.4-1.31.71.9-0.7-0.91.1
Locomotion distance, session 31.82.16.71.00.7-1.11.11.2-1.11.61.0-2.22.52.6-1.10.00.3
Stereotopy head waving bouts, day 30.70.91.71.21.1-1.31.31.3-0.7-0.51.1-0.40.80.4-0.9-0.60.7
Stereotopy head waving duration, day 30.40.51.01.00.7-1.01.00.9-0.2-0.40.7-0.50.80.4-0.8-0.10.1
Locomotion velocity, session 70.40.51.1-1.0-0.70.8-0.9-0.70.21.1-0.3-1.00.20.80.10.5-0.4
Locomotion distance, session 71.52.06.2-1.2-1.61.1-1.1-1.01.12.5-0.9-2.31.02.0-0.11.0-0.7
Stereotopy head waving bouts, day 70.20.30.90.60.4-0.40.50.40.1-0.4-0.10.40.0-0.6-0.40.9-0.9
Stereotopy head waving duration, day 70.10.10.40.40.3-0.30.30.20.2-0.4-0.00.4-0.1-0.60.20.6-0.6
Locomotion velocity, session 80.50.62.3-0.0-0.30.0-0.1-0.30.71.3-0.3-1.31.51.11.00.5-0.1
Locomotion distance, session 82.63.77.3-1.7-2.01.8-1.8-2.12.71.9-2.5-1.10.40.31.32.7-2.6
Degree of sensitization distance1.82.03.4-1.8-1.61.9-1.8-1.81.5-0.0-1.50.7-1.8-1.21.30.3-0.3
Degree of sensitization stereotypy0.20.21.10.30.1-0.10.10.00.3-0.0-0.40.30.0-0.5-0.11.0-1.0
Conditioned locomotion1.92.24.4-1.5-1.11.4-1.5-1.71.6-0.6-1.71.6-1.7-1.82.10.7-0.8
Cocaine response after cond. corrected0.50.81.41.00.9-1.21.21.2-1.1-0.10.9-0.10.70.9-0.7-0.80.8
Cocaine response after cond. not corrected0.60.82.00.90.7-1.01.01.0-1.00.50.8-0.71.21.4-1.0-0.30.4
Cocaine response before conditioning0.81.02.1-0.6-0.80.7-0.8-0.70.71.5-0.8-1.40.91.1-0.31.3-1.3
Saline control response1.31.86.6-1.5-0.91.4-1.4-1.50.8-0.5-1.01.6-1.6-1.42.6-0.70.7
Bone: connectivity density0.61.03.3-1.2-1.21.2-1.2-1.31.10.6-0.9-0.1-0.8-0.51.80.5-0.2
Bone: cortical apparent density0.61.03.10.50.1-0.50.50.7-0.71.00.9-1.61.31.8-0.8-0.91.2
Bone: cortical area2.74.510.73.33.2-3.13.02.6-1.1-2.51.11.71.8-1.10.20.1-0.3
Bone: cortical porosity2.42.64.52.02.1-1.91.91.9-1.9-2.11.51.2-0.1-0.7-2.1-0.80.3
Bone: cortical porosity1.92.15.11.71.8-1.61.61.6-1.6-2.31.31.4-0.5-1.1-1.5-0.90.4
Bone: cortical thickness6.010.024.44.94.5-4.74.64.1-2.1-3.02.51.82.8-0.7-0.5-1.41.3
Bone: cortical thickness2.83.48.52.92.4-2.72.72.5-1.0-1.51.50.72.0-0.1-0.7-1.01.0
Bone: cortical tissue density0.61.03.00.4-0.0-0.40.40.6-0.61.01.0-1.61.11.7-0.8-1.01.3
Condit. Reinf. active minus inactive responses0.40.51.80.10.20.0-0.0-0.10.4-1.0-0.41.4-0.8-1.31.2-0.0-0.0
Condit. Reinf. active-inactive response ratio0.40.42.00.80.6-0.50.60.4-0.2-0.60.20.70.1-0.61.4-0.40.5
Condit. Reinf. active responses0.91.23.9-0.4-0.30.5-0.5-0.71.0-1.1-1.11.9-1.6-2.01.20.4-0.5
Condit. Reinf. inactive responses0.70.92.2-1.2-0.81.0-1.0-1.00.9-0.4-1.11.1-1.5-1.30.10.5-0.6
Incentive salience index mean0.40.51.4-0.3-0.30.4-0.4-0.50.7-0.5-0.81.1-1.0-1.21.00.4-0.4
Condit. Reinf. lever presses0.50.81.3-1.0-1.11.0-0.9-0.91.11.1-1.1-0.3-0.40.0-0.10.9-1.0
Condit. Reinf. active minus inactive responses0.30.41.31.10.9-0.90.90.50.0-0.40.20.40.7-0.20.90.00.1
Condit. Reinf. active-inactive response ratio0.71.22.51.41.4-1.31.31.0-0.4-1.60.61.6-0.3-1.30.4-0.70.5
Condit. Reinf. active responses0.10.20.70.70.4-0.40.40.10.10.2-0.1-0.10.70.40.80.3-0.2
Condit. Reinf. inactive responses0.30.52.3-0.0-0.30.2-0.2-0.2-0.11.2-0.2-1.31.01.50.40.5-0.2
Condit. Reinf. lever presses0.20.30.8-0.4-0.60.5-0.4-0.60.80.3-0.9-0.0-0.10.00.80.5-0.5
Condit. Reinf. lever reinforcers received0.10.20.50.40.1-0.10.1-0.10.40.3-0.4-0.20.50.40.70.7-0.6
Conditioned reinforcement - actives0.10.31.1-0.2-0.50.0-0.1-0.20.41.0-0.6-0.70.50.8-0.70.6-0.7
Conditioned reinforcement - inactives0.00.10.40.2-0.1-0.10.10.1-0.1-0.1-0.40.2-0.20.4-0.60.3-0.6
Conditioned locomotion0.20.31.1-0.2-0.40.00.0-0.20.10.5-0.9-0.5-0.20.70.20.8-1.0
Patch foraging indifference point 0 sec0.10.20.9-0.6-0.30.6-0.7-0.6-0.10.1-0.20.2-0.50.11.0-0.30.4
Patch foraging indifference point AUC0.10.30.6-0.5-0.70.6-0.7-0.70.80.0-0.50.3-0.7-0.5-0.00.0-0.1
Delay disc. indifference point, 0s delay0.30.31.00.70.6-0.80.80.7-0.20.30.4-0.31.00.60.3-0.30.4
Delay disc. indifference point, 16s delay1.21.76.5-0.9-1.20.7-0.7-1.00.82.6-1.1-1.91.01.6-0.01.7-1.3
Delay disc. indifference point, 2s delay0.30.30.80.50.4-0.40.40.5-0.60.30.4-0.60.80.9-0.80.4-0.3
Delay disc. indifference point, 24s delay1.11.83.61.10.9-1.11.21.3-1.60.91.4-1.91.81.9-1.5-0.40.7
Delay disc. indifference point, 4s delay0.60.61.80.60.3-0.60.60.5-0.70.90.6-0.50.90.61.0-0.91.3
Delay disc. indifference point, 8s delay0.50.92.20.80.8-0.80.80.8-1.30.91.1-0.71.51.1-0.4-0.71.0
Indifference point function ln k0.20.73.10.50.4-0.50.50.5-0.31.20.7-1.41.81.30.30.00.4
Indifference point function log k0.20.73.10.50.4-0.50.50.5-0.31.20.7-1.41.81.30.30.00.4
Patch foraging total patch changes 0 sec0.10.21.1-0.5-0.30.6-0.6-0.70.00.2-0.20.2-0.40.21.0-0.20.4
Patch foraging total patch changes 12 sec0.20.20.9-0.3-0.30.6-0.5-0.40.0-0.6-0.10.7-1.0-0.4-0.4-0.40.2
Patch foraging total patch changes 18 sec0.20.51.1-0.5-0.80.9-0.9-1.00.70.9-0.7-0.4-0.20.40.90.6-0.3
Patch foraging total patch changes 24 sec0.10.31.0-0.0-0.10.3-0.3-0.50.1-0.4-0.20.7-0.7-0.61.0-0.50.6
Patch foraging total patch changes 6 sec0.10.20.9-0.10.00.2-0.2-0.20.1-0.6-0.00.9-0.8-0.90.2-0.40.3
Patch foraging time to switch 0 sec0.00.20.6-0.3-0.30.3-0.2-0.10.10.4-0.0-0.70.10.4-0.80.4-0.5
Patch foraging water rate 0 sec0.10.42.2-0.1-0.20.3-0.4-0.60.0-0.1-0.81.1-0.5-0.31.50.00.0
Patch foraging water rate 12 sec0.10.31.20.70.2-0.60.60.30.40.6-0.2-0.31.10.70.30.2-0.0
Patch foraging water rate 18 sec0.10.31.10.3-0.2-0.10.1-0.30.70.4-0.7-0.20.5-0.11.10.7-0.6
Patch foraging water rate 24 sec0.40.53.10.3-0.30.0-0.1-0.50.7-0.0-1.20.20.1-0.01.81.0-0.9
Patch foraging water rate 6 sec0.60.93.31.50.8-1.21.20.8-0.40.30.2-0.71.81.4-0.30.10.0
Seeking ratio, delayed vs. immediate footshock0.30.51.6-0.3-0.10.3-0.3-0.30.5-0.4-0.31.1-0.7-1.01.3-1.00.9
Distance traveled before self-admin0.30.71.90.70.8-0.60.70.7-1.3-1.40.51.0-0.4-0.70.8-0.60.6
Distance traveled after self-admin1.32.35.2-2.3-1.71.9-1.9-2.00.90.5-1.80.6-2.0-0.90.90.9-1.1
Extensor digitorum longus weight0.31.24.4-0.8-1.00.8-0.8-1.02.11.0-1.4-0.30.2-0.40.11.7-1.7
Bone: elastic displacement0.60.82.30.90.9-0.80.80.7-0.4-1.50.51.2-0.3-1.10.6-1.00.9
Bone: elastic work4.86.314.53.03.2-2.82.82.6-1.8-3.82.13.2-0.2-2.30.3-2.42.1
Bone: endosteal estimation1.02.47.4-1.6-1.41.7-1.7-1.61.30.9-1.8-0.6-0.7-0.10.12.6-2.7
Bone: endosteal perimeter0.40.91.8-1.1-0.21.0-1.0-0.80.1-0.9-0.61.0-1.3-1.31.30.6-0.7
Epididymis fat weight0.21.03.2-0.7-0.60.8-0.9-1.01.1-0.3-1.50.8-0.3-0.6-0.11.5-1.8
Delta time in closed arm before/after self-admin1.01.02.4-0.9-1.31.1-1.0-1.21.51.5-0.9-0.60.20.60.50.8-0.4
Delta time in open arm before/after self-admin0.10.10.20.2-0.00.1-0.10.1-0.4-0.20.2-0.2-0.40.4-0.5-0.50.4
Diff in mean of infusions in LGA sessions0.10.20.7-0.9-0.10.6-0.5-0.3-0.70.3-0.10.4-0.6-0.3-0.20.2-0.3
Delay discount exponential model param0.70.93.0-0.5-0.20.5-0.5-0.50.9-1.6-0.61.5-1.6-1.70.40.0-0.4
Extinction: sum of active levers before priming1.21.83.41.81.5-1.71.71.7-1.1-0.91.6-0.61.20.4-1.6-1.11.1
Active lever presses in extinction session 65.65.610.52.82.9-3.03.03.1-3.2-1.12.4-0.62.21.8-2.7-0.90.7
Bone: final force2.03.38.83.02.6-2.62.62.1-0.7-2.20.51.81.3-1.30.30.5-0.8
Bone: final moment2.43.99.63.12.9-2.72.72.2-0.8-2.70.82.21.0-1.70.30.2-0.5
Food consumed during 24 hour testing period0.30.61.3-0.9-0.70.9-0.9-0.90.6-0.4-0.50.8-1.1-0.91.0-0.40.4
Glucose8.413.322.84.23.9-4.64.54.8-4.5-1.14.5-1.12.62.6-4.2-2.82.7
Heart weight1.22.04.72.21.8-1.91.91.8-0.7-1.80.81.00.7-0.8-1.5-0.4-0.2
Delay discount hyperbolic model param0.60.82.5-0.5-0.30.6-0.6-0.60.9-1.4-0.61.4-1.5-1.60.50.1-0.5
Intermittent access intake day 1-15 change0.10.72.4-1.2-0.41.1-1.1-0.8-1.1-0.7-0.41.0-1.6-0.00.6-0.50.3
Intermittent access intake escalation0.10.81.9-1.1-0.31.0-1.1-0.8-1.2-0.5-0.20.9-1.40.01.0-0.80.6
Intermittent access intake escalation 20.61.13.6-0.50.40.3-0.30.0-1.9-1.80.21.6-1.8-0.50.5-1.10.6
Intermitt. access day 1 inactive lever presses0.11.63.8-1.5-1.41.4-1.4-1.61.00.3-2.01.0-1.5-0.71.10.9-1.2
Intermitt. access day 15 inactive lever presses0.21.02.7-0.9-1.11.1-1.1-1.11.00.3-1.40.4-1.1-0.61.60.7-0.7
Intermitt. access escalation Index0.51.43.3-1.6-1.51.5-1.5-1.71.00.4-1.00.5-1.3-0.71.8-0.10.4
Intermittent access day 1 total infusions0.10.30.90.80.2-0.60.80.60.40.0-0.20.10.6-0.4-1.00.5-0.7
Intermittent access day 15 total infusions0.10.20.5-0.4-0.30.5-0.4-0.4-0.1-0.2-0.50.7-0.7-0.40.5-0.20.0
Intermittent access terminal intake (last 3 days)0.20.41.6-0.6-0.40.6-0.5-0.4-0.2-0.5-0.51.0-1.3-0.80.5-0.30.0
Intermittent access total infusions0.10.10.2-0.1-0.30.3-0.2-0.30.10.5-0.40.3-0.2-0.20.10.0-0.1
Intermittent access day 1 locomotion0.20.31.00.70.1-0.50.60.3-0.30.8-0.1-0.60.81.0-0.30.1-0.1
Intermittent access day 15 total locomotion0.00.10.30.00.1-0.10.10.1-0.5-0.3-0.20.5-0.40.10.40.0-0.2
Intermittent access total locomotion0.10.10.60.30.1-0.10.20.1-0.50.4-0.2-0.00.30.70.00.0-0.0
Intermittent access standard deviation0.31.55.11.11.3-1.11.11.3-2.30.31.3-0.31.01.5-1.6-0.80.6
Left kidney weight0.32.56.42.52.1-2.22.12.0-1.0-0.71.1-0.21.90.8-1.90.5-0.7
Right kidney weight0.43.08.62.92.2-2.42.42.1-1.0-0.71.4-0.52.31.1-1.70.1-0.1
Cocaine induced anxiety2.15.710.52.93.0-2.93.03.2-3.2-2.42.51.21.10.4-1.2-2.22.0
Post-drug Anxiety4.55.210.12.82.7-2.72.73.0-3.2-1.42.50.41.71.3-1.4-2.02.0
Baseline Anxiety0.20.41.1-0.7-0.70.7-0.7-0.70.21.0-0.2-1.00.20.8-0.20.4-0.2
Tail length0.74.09.4-1.9-1.11.7-1.8-1.91.1-1.5-2.23.1-3.1-2.81.90.9-1.4
Length with tail0.31.24.31.11.5-1.11.11.0-1.4-1.50.32.1-0.5-0.7-0.20.0-0.4
Length without tail1.47.215.53.93.6-3.73.73.6-3.0-1.32.70.72.00.9-2.3-1.31.1
Times rat made contact with spout2.22.510.6-1.0-0.51.1-1.0-0.9-0.0-2.3-0.12.3-3.3-2.40.7-1.61.1
Lifetime Intake0.10.10.60.1-0.20.1-0.1-0.1-0.00.8-0.2-0.00.20.2-0.3-0.20.1
Liver weight, left0.91.65.40.90.7-1.21.21.3-0.81.00.6-1.21.71.9-2.30.6-0.7
Liver weight, right0.50.92.4-0.5-0.50.6-0.6-0.71.0-0.5-1.40.9-0.9-0.90.61.3-1.5
Locomotor activity0.20.41.70.4-0.0-0.20.20.1-0.20.30.0-1.00.51.2-1.30.4-0.5
Locomotor testing distance0.30.83.20.0-0.40.1-0.2-0.30.41.3-0.1-1.81.11.6-0.80.8-0.6
Locomotor testing rearing0.20.91.9-1.2-1.41.3-1.3-1.30.70.9-0.9-1.0-0.40.80.00.4-0.4
Locomotion in novel chamber0.30.32.1-0.5-0.20.2-0.2-0.30.51.40.0-0.70.60.70.50.6-0.2
Locomotion in novel chamber post-restriction0.82.34.9-1.7-0.81.7-1.7-1.60.6-0.9-1.22.2-2.2-2.21.50.6-0.7
Fecal boli incidents, locomotor time 10.20.62.1-0.2-0.70.5-0.5-0.51.00.5-0.7-0.80.00.1-1.01.2-1.4
Change in fecal boli incidents, locomotor task1.21.33.50.50.9-0.60.60.8-1.90.11.5-0.20.61.1-1.6-1.61.7
Time >=10cm from walls, locomotor time 11.82.27.7-1.9-1.61.9-2.0-2.01.20.9-1.50.3-1.1-0.62.80.5-0.0
Bouts of movement, locomotor time 10.50.61.50.70.5-0.91.00.9-0.20.40.9-0.91.00.4-1.2-0.50.5
Total resting periods, locomotor time 10.60.71.60.70.6-0.91.00.9-0.40.41.0-0.91.00.4-1.3-0.70.7
Rest time, locomotor task time 10.20.32.20.40.4-0.50.60.6-0.5-0.60.5-0.0-0.2-0.1-1.5-0.40.0
Distance moved, locomotor task time 10.10.30.9-0.6-0.40.4-0.4-0.6-0.40.9-0.4-0.10.20.70.80.20.1
Vertical activity count, locomotor time 10.10.41.2-0.7-0.60.6-0.6-0.80.40.6-0.90.2-0.20.11.10.8-0.5
Time >=10cm from walls, locomotor time 20.10.30.60.70.6-0.70.80.70.2-0.40.40.30.6-0.70.8-0.30.4
Bouts of movement, locomotor time 20.20.62.90.1-0.2-0.20.30.10.11.70.1-1.21.31.2-1.10.4-0.2
Total resting periods, locomotor time 20.20.73.3-0.4-0.60.3-0.2-0.40.71.8-0.4-1.10.90.9-0.70.9-0.8
Rest time, locomotor task time 20.50.81.7-1.3-0.81.3-1.3-1.20.60.4-0.70.1-0.9-0.5-0.30.8-0.9
Distance moved, locomotor task time 20.50.71.81.00.6-1.21.31.1-0.60.40.6-0.31.40.6-0.0-0.70.8
Vertical activity count, locomotor time 20.20.51.61.00.3-0.91.00.70.30.3-0.3-0.71.30.6-0.30.6-0.7
Light reinforcement 10.52.25.3-1.8-1.71.7-1.7-1.82.30.1-1.40.9-1.6-1.51.5-0.00.1
Light reinforcement 20.40.81.7-0.9-0.70.9-0.9-1.11.3-0.4-1.01.1-1.1-1.30.70.2-0.3
Bone: marrow area0.92.37.2-1.6-1.41.6-1.6-1.51.20.9-1.7-0.7-0.6-0.00.02.6-2.7
Bone: maximum diameter0.50.92.51.31.6-1.31.21.1-0.6-1.20.40.80.8-0.60.40.5-0.7
Bone: maximum force1.53.17.82.82.5-2.42.41.9-0.4-2.10.31.81.3-1.30.20.9-1.2
Bone: maximum moment1.93.68.62.92.7-2.52.52.0-0.6-2.60.52.21.0-1.70.20.6-0.9
Mean time between licks in bursts0.10.72.40.3-0.2-0.20.20.3-0.11.40.3-1.51.21.5-0.7-0.10.3
Mean num. licks in bursts0.30.82.8-0.10.4-0.00.00.2-0.8-1.70.51.3-1.5-1.00.1-1.10.8
Cd content in liver1.11.22.2-1.1-1.31.1-1.1-1.01.21.1-1.4-1.00.20.5-0.21.4-1.5
Co content in liver0.20.20.6-0.6-0.50.7-0.7-0.50.1-0.3-0.20.1-0.8-0.40.4-0.10.1
Cu content in liver0.60.81.70.10.6-0.10.10.2-0.9-1.30.61.3-1.1-1.00.7-1.31.2
Fe content in liver0.70.82.2-0.6-0.80.7-0.6-0.60.51.3-0.8-1.20.40.9-0.51.5-1.5
K content in liver3.02.95.5-2.3-2.22.3-2.3-2.31.70.8-2.00.3-1.6-0.62.20.6-0.4
Mg content in liver3.94.38.2-2.8-2.92.8-2.7-2.72.31.3-2.5-0.4-1.3-0.11.91.1-0.9
Mn content in liver0.10.10.50.30.1-0.40.40.20.1-0.00.00.10.3-0.00.2-0.70.7
Na content in liver0.50.61.1-1.0-1.01.0-1.0-0.90.50.9-0.8-0.6-0.10.60.90.3-0.2
Rb content in liver1.21.44.9-0.9-1.11.2-1.1-1.21.5-0.5-1.50.9-1.0-1.42.20.4-0.4
Se content in liver0.80.92.2-1.2-1.11.2-1.1-1.20.7-0.1-0.80.6-1.5-0.91.1-0.60.5
Sr content in liver1.51.32.91.01.3-1.21.21.2-1.4-0.81.60.50.2-0.1-0.5-1.71.7
Zn content in liver1.51.73.1-1.6-1.31.6-1.6-1.51.2-0.5-1.51.0-1.8-1.10.70.9-1.1
Bone: minimum diameter0.61.23.70.71.2-0.60.60.4-0.4-1.90.31.9-0.7-1.81.3-0.20.1
Time in familiar zone, hab. session 10.50.51.01.00.8-0.90.91.0-0.7-0.70.70.30.30.1-0.8-0.70.6
Time in novel zone, hab. session 10.20.20.5-0.5-0.50.5-0.5-0.70.50.4-0.3-0.1-0.2-0.10.6-0.10.3
Total zone transitions, hab. session 10.30.41.10.70.2-0.80.80.60.20.30.1-0.81.10.8-0.90.2-0.3
Total locomotion distance, hab. session 10.20.31.30.4-0.1-0.30.40.20.90.1-0.6-0.30.5-0.0-0.41.1-1.1
Locomotion velocity, hab. session 10.30.42.10.2-0.2-0.20.20.11.00.1-0.7-0.30.3-0.1-0.51.3-1.5
Time in familiar zone, hab. session 20.20.20.5-0.3-0.40.3-0.3-0.20.40.7-0.2-0.60.30.5-0.70.3-0.3
Time in novel zone, hab. session 20.20.20.50.70.5-0.60.60.4-0.3-0.00.3-0.20.50.20.4-0.20.4
Total zone transitions, hab. session 20.81.14.1-0.6-1.10.7-0.7-1.02.01.1-1.3-0.90.70.20.41.2-1.1
Total locomotion distance, hab. session 21.21.66.2-0.9-1.41.0-1.0-1.32.50.8-1.8-0.20.0-0.40.61.7-1.7
Locomotion velocity, hab. session 21.11.55.7-0.8-1.31.0-1.0-1.22.40.5-1.7-0.0-0.1-0.60.81.6-1.6
Novel to familiar place preference ratio1.31.73.91.21.5-1.21.21.0-1.1-2.01.11.9-0.6-1.40.4-1.41.2
Novelty place preference1.41.84.11.31.6-1.21.21.0-1.2-2.01.21.9-0.6-1.40.4-1.51.3
Time in novel zone, NPP test1.21.43.21.21.4-1.11.10.9-1.0-1.81.01.7-0.5-1.20.4-1.31.2
Total zone transitions, NPP test1.62.45.1-1.3-1.81.3-1.3-1.62.31.9-1.9-1.50.60.70.82.0-1.8
Total locomotion distance, NPP test2.02.87.0-1.3-2.01.5-1.4-1.72.71.4-2.3-1.00.10.20.62.4-2.4
Locomotion velocity, NPP test1.42.05.2-1.2-1.61.2-1.2-1.52.31.0-2.0-0.6-0.1-0.10.62.0-2.1
Intraocular pressure0.81.22.7-1.1-0.81.1-1.2-1.20.7-0.1-1.50.7-1.3-0.81.01.5-1.6
Delta distance traveled before/after self-admin1.41.63.9-2.0-1.61.6-1.8-1.71.21.5-1.2-0.6-0.80.3-0.10.5-0.6
Delta ambulatory time before/after self-admin1.52.66.3-2.5-2.12.1-2.2-2.21.72.0-1.4-1.0-1.00.4-0.10.7-0.6
Parametrial fat weight0.41.02.5-0.9-1.20.9-0.9-1.01.6-0.2-1.40.8-1.2-1.0-0.10.5-0.8
Pavlov. Cond. lever latency1.21.63.1-1.0-1.31.1-1.1-1.21.21.4-1.3-1.60.61.20.51.8-1.6
Pavlov. Cond. magazine entry latency1.41.84.01.11.5-1.11.11.0-1.5-1.61.22.0-0.9-1.10.2-1.81.7
Pavlov. Cond. change in total contacts1.51.63.01.71.5-1.51.51.5-1.5-1.11.40.90.0-0.2-1.3-1.31.1
Pavlov. Cond. index score1.11.44.80.71.1-0.70.70.6-0.9-1.60.82.2-1.2-1.60.2-1.41.3
Pavlov. Cond. latency score1.21.54.50.81.2-0.80.70.7-1.0-1.71.02.1-1.2-1.6-0.0-1.61.4
Pavlov. Cond. lever contacts0.40.41.20.50.6-0.50.50.5-0.5-0.70.51.1-0.6-0.9-0.4-0.80.6
Pavlov. Cond. magazine entry number2.32.95.0-1.6-2.01.6-1.6-1.52.02.2-1.6-2.20.91.20.52.0-1.8
Pavlov. Cond. intertrial magazine entries0.81.02.3-1.1-1.21.1-1.1-1.11.50.4-1.30.1-0.5-0.60.41.1-1.2
Pavlov. Cond. lever-magazine prob. diff.1.11.44.20.91.2-0.80.80.7-1.0-1.50.82.1-1.0-1.40.3-1.41.4
Pavlov. Cond. response bias1.72.13.41.51.7-1.51.41.4-1.7-1.71.41.9-0.6-1.0-0.7-1.71.6
Pavlov. Cond. lever latency1.01.42.61.31.2-1.31.31.5-1.50.11.6-0.51.20.8-1.3-1.01.1
Pavlov. Cond. magazine entry latency1.11.63.3-1.0-1.50.9-0.8-1.01.21.6-1.3-1.80.41.5-0.91.4-1.5
Pavlov. Cond. change in total contacts0.20.61.0-0.7-0.80.8-0.8-0.90.70.7-0.9-0.7-0.10.60.51.0-1.0
Pavlov. Cond. index score0.50.81.7-0.8-1.10.8-0.7-0.91.00.6-1.3-0.7-0.30.5-0.21.1-1.3
Pavlov. Cond. latency score0.61.02.0-1.0-1.31.0-0.9-1.11.30.7-1.4-0.7-0.40.40.11.2-1.3
Pavlov. Cond. lever contacts1.01.52.5-1.4-1.31.4-1.4-1.51.5-0.0-1.60.4-1.2-0.71.31.0-1.0
Pavlov. Cond. magazine entry number1.01.32.71.01.4-0.80.81.0-0.9-1.61.21.6-0.4-1.50.7-1.11.2
Pavlov. Cond. intertrial magazine entries0.30.62.80.20.00.2-0.2-0.30.4-0.8-0.51.3-0.9-1.51.70.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.50.81.6-0.8-1.10.7-0.7-0.90.90.8-1.2-0.8-0.10.7-0.31.1-1.2
Pavlov. Cond. response bias0.50.71.4-0.9-1.00.9-0.9-1.01.00.5-1.2-0.4-0.30.30.20.9-1.1
Time in closed arm before self-admin0.81.42.21.31.5-1.41.41.5-1.4-0.91.30.01.0-0.0-0.6-1.21.1
Time in closed arm after self-admin0.40.51.30.50.5-0.50.60.6-1.10.50.9-0.31.00.9-0.6-0.70.9
Time in open arm before self-admin0.81.04.0-1.0-1.11.0-0.9-1.12.01.0-0.9-0.1-0.4-0.91.01.0-0.7
Time in open arm after self-admin0.10.10.40.1-0.30.2-0.1-0.20.60.4-0.4-0.5-0.20.40.00.6-0.6
Bone: periosteal estimation0.40.92.81.01.2-0.80.80.7-0.0-1.1-0.30.80.6-0.90.31.5-1.7
Bone: periosteal perimeter1.63.28.22.02.7-2.02.01.9-1.7-2.91.42.20.0-1.60.3-0.90.6
Bone: post-yield work0.10.20.60.20.1-0.10.1-0.00.20.6-0.2-0.50.70.50.20.8-0.6
Progressive ratio test 1 active lever presses0.10.20.5-0.4-0.40.5-0.5-0.5-0.30.7-0.50.1-0.10.50.20.1-0.1
Progressive ratio test 1 breakpoint0.10.20.4-0.4-0.40.5-0.5-0.6-0.30.7-0.50.2-0.20.40.20.1-0.1
Progressive ratio test 1 inactive lever presses0.51.43.0-1.0-1.21.4-1.3-1.51.1-0.0-1.71.0-1.3-1.01.10.8-1.0
Progressive ratio test 2 active lever presses0.10.20.7-0.4-0.60.5-0.5-0.50.20.0-0.80.2-0.50.1-0.00.5-0.7
Progressive ratio test 2 breakpoint0.10.20.6-0.4-0.50.5-0.4-0.50.20.1-0.80.2-0.50.2-0.00.4-0.6
Progressive ratio test 2 inactive lever presses0.00.10.40.40.4-0.40.40.4-0.6-0.50.00.30.10.4-0.4-0.1-0.1
Incentive Sensitization - Responses0.20.61.4-0.8-0.80.7-0.7-0.70.8-0.7-1.00.6-1.2-0.60.20.4-0.7
Incentive Sensitization - Breakpoint0.20.51.3-0.7-0.70.6-0.5-0.60.7-0.8-0.90.6-1.1-0.50.10.3-0.6
Sum of active levers in priming session hrs 5-61.21.12.61.01.0-1.21.31.2-1.4-1.40.80.9-0.4-0.1-1.6-1.00.5
Progressive ratio0.30.81.70.90.5-0.60.70.8-0.30.60.2-1.21.20.8-1.21.3-1.3
Food seeking constrained by brief footshock0.30.41.2-0.10.5-0.20.30.6-1.1-0.40.90.3-0.1-0.4-0.2-1.11.1
Seeking ratio, punishment vs. effort0.30.62.0-0.8-0.50.5-0.5-0.60.4-0.2-0.00.6-0.8-0.61.4-1.11.3
Retroperitoneal fat weight1.04.38.0-1.9-1.51.9-1.9-2.11.9-1.0-2.82.1-2.5-2.31.62.2-2.6
Reaction time number correct1.13.98.1-1.7-2.42.1-2.1-2.42.92.1-2.5-1.1-0.30.22.02.0-1.7
Reaction time mean minus median0.00.21.8-0.30.30.2-0.20.2-0.9-0.20.40.1-0.2-0.0-1.3-0.1-0.1
Reaction time mean minus median AUC0.00.00.2-0.10.10.2-0.2-0.1-0.4-0.00.20.1-0.1-0.2-0.40.0-0.1
Reaction time num false alarms0.00.10.2-0.1-0.10.1-0.1-0.10.2-0.50.1-0.2-0.3-0.1-0.40.2-0.3
Reaction time num false alarms AUC0.10.10.4-0.2-0.30.3-0.3-0.30.50.0-0.1-0.6-0.00.2-0.50.4-0.4
Reaction time trials correct on left1.13.98.1-1.7-2.42.1-2.1-2.42.92.1-2.5-1.1-0.30.22.02.0-1.7
Reaction time trials on left1.24.18.4-1.8-2.52.2-2.1-2.42.92.1-2.6-1.2-0.30.32.12.1-1.7
Reaction time mean0.10.20.4-0.3-0.10.4-0.4-0.30.4-0.5-0.30.5-0.4-0.6-0.40.2-0.4
Reaction time mean AUC0.10.30.8-0.6-0.40.7-0.7-0.70.8-0.0-0.70.2-0.2-0.5-0.10.7-0.9
Median of all reaction times0.10.10.4-0.2-0.20.4-0.3-0.40.6-0.4-0.40.4-0.2-0.50.00.3-0.4
Reaction time omissions0.30.41.2-1.1-0.61.1-1.0-0.90.40.2-0.6-0.1-0.2-0.10.30.5-0.5
Reaction time false alarm rate0.50.71.90.60.9-0.80.70.9-1.0-1.21.20.1-0.0-0.1-1.4-0.80.6
Reaction time premature initiation rate0.20.21.1-0.1-0.30.0-0.10.10.10.70.2-0.90.40.8-1.1-0.20.2
Reaction time premature initiations0.51.53.5-1.2-1.71.2-1.3-1.31.71.9-1.3-1.30.10.70.21.1-0.9
Std. dev. reaction times0.10.20.8-0.7-0.20.6-0.6-0.40.00.1-0.1-0.40.10.1-0.90.3-0.5
Reaction time trials completed1.24.18.4-1.8-2.52.2-2.1-2.42.92.1-2.6-1.2-0.30.32.12.1-1.7
Reaction time trials AUC1.13.98.3-1.7-2.42.1-2.1-2.42.92.1-2.5-1.1-0.30.22.12.0-1.6
Run reversals in cocaine runway, females0.30.31.2-0.7-0.90.5-0.4-0.41.10.8-0.6-0.7-0.00.10.00.3-0.3
Run reversals in cocaine runway, males0.70.72.80.20.5-0.20.10.3-0.7-1.50.31.7-1.6-1.1-0.1-0.70.3
Latency to leave start box in cocaine runway0.50.62.1-0.5-0.90.5-0.5-0.61.00.2-0.9-0.8-0.20.2-1.01.1-1.5
Latency to leave start box in cocaine runway, F1.61.94.7-1.2-1.71.2-1.2-1.52.20.8-1.8-1.1-0.2-0.1-0.11.9-2.1
Latency to leave start box in cocaine runway, M0.30.21.20.40.4-0.50.40.5-0.7-0.50.40.2-0.20.2-1.1-0.30.1
Std. dev. time between licks in bursts1.32.54.6-1.3-1.91.7-1.6-1.92.01.8-2.1-0.80.20.31.81.6-1.4
Total sessions with >9 infusions0.30.41.60.40.1-0.10.10.1-0.21.30.2-0.81.01.0-0.90.3-0.2
Short access day 1 total inactive lever presses0.40.82.40.2-0.3-0.20.3-0.10.81.6-0.7-0.91.20.9-0.91.3-1.3
Short access day 10 total inactive lever presses0.10.92.6-0.6-0.70.7-0.7-0.90.8-0.1-1.31.3-1.0-0.91.60.7-0.8
Short access day 1 total infusions0.51.02.60.90.3-0.60.70.6-0.41.50.8-1.51.61.4-1.1-0.40.6
Short access day 10 total infusions0.20.31.0-0.4-0.40.8-0.6-0.5-0.40.1-0.51.0-1.0-0.70.2-0.0-0.2
Short access total infusions0.10.21.10.3-0.10.00.00.1-0.41.10.1-0.30.50.6-0.7-0.30.3
Short access day 1 locomotion0.81.32.11.51.1-1.21.31.3-1.40.31.2-0.61.31.0-0.8-1.01.1
Short access day 10 total locomotion0.31.22.41.21.1-1.21.31.4-1.6-0.21.20.20.30.4-0.9-1.31.2
Short access total locomotion0.81.12.41.31.1-1.11.11.2-1.50.31.2-0.00.90.9-1.0-1.11.1
One hour access (0.3 mA shock)0.30.41.3-0.4-0.80.4-0.3-0.50.9-0.1-0.90.4-1.1-0.60.00.3-0.6
Compulsive drug intake0.71.02.7-1.1-1.20.9-0.8-1.21.60.4-1.20.5-1.2-0.91.30.7-0.6
One hour access (shock baseline)0.10.20.4-0.5-0.60.6-0.6-0.50.60.1-0.60.1-0.5-0.3-0.30.3-0.5
Social response proportion0.40.52.4-0.0-0.10.2-0.2-0.2-0.21.3-0.1-1.11.31.50.10.4-0.1
Social responses0.40.62.90.20.00.1-0.1-0.30.11.30.3-1.01.71.40.4-0.00.5
Social time0.30.41.80.70.5-0.70.70.50.20.50.3-0.81.40.8-0.30.4-0.2
Soleus weight0.51.56.1-0.6-0.40.8-0.7-0.90.9-1.1-0.52.0-1.7-2.51.7-0.70.6
Bone: stiffness1.32.46.02.41.7-2.12.11.7-0.2-0.30.1-0.32.50.7-1.21.5-1.7
Tibialis anterior weight0.10.52.0-0.6-0.80.7-0.7-0.81.40.4-0.70.1-0.6-0.9-0.00.7-0.6
Time to tail flick, vehicle, before self-admin0.00.00.2-0.3-0.20.1-0.2-0.1-0.0-0.3-0.1-0.3-0.0-0.00.40.10.0
Time to tail flick, vehicle, after self-admin0.51.03.40.70.1-0.80.70.60.41.40.4-1.61.91.2-1.20.3-0.2
Time to tail flick, test, before self-admin0.20.20.7-0.6-0.40.5-0.6-0.5-0.30.6-0.4-0.20.10.8-0.2-0.30.1
Time to tail flick, test, after self-admin0.80.83.00.50.5-0.60.50.7-1.50.90.8-0.81.21.7-0.7-0.50.7
Delta time to tail flick, vehicle, before/after SA0.50.51.6-0.3-0.80.5-0.4-0.51.31.3-0.7-0.40.1-0.0-0.60.8-0.8
Delta time to tail flick, test, before/after SA1.31.63.21.71.5-1.71.71.8-1.4-0.41.6-0.51.30.7-1.1-0.40.6
Tibia length3.39.124.53.64.0-3.23.22.7-1.7-5.01.64.6-0.5-3.81.4-1.10.6
Ambulatory time before self-admin0.41.13.11.01.1-0.80.80.8-1.3-1.80.51.5-0.3-1.01.2-0.70.7
Ambulatory time after self-admin0.50.71.9-1.4-0.91.0-1.1-1.10.40.1-0.90.5-1.3-0.60.70.4-0.5
Bone: tissue strength0.40.41.60.60.4-0.40.40.20.6-0.6-0.60.40.4-0.50.71.2-1.3
Total heroin consumption2.12.54.71.92.1-2.12.12.2-2.1-0.81.5-0.21.40.8-1.8-0.2-0.1
Bone: trabecular number0.10.20.5-0.3-0.30.3-0.2-0.30.2-0.40.00.5-0.7-0.60.5-0.60.6
Bone: trabecular spacing1.92.76.3-1.4-1.71.5-1.5-1.62.01.7-2.2-1.00.30.31.02.5-2.5
Bone: trabecular thickness1.52.14.70.91.4-1.01.01.0-1.5-2.21.61.7-1.1-1.1-0.0-2.12.0
Bone: trabecular tissue density0.30.51.80.4-0.1-0.20.20.2-0.30.9-0.1-1.31.01.2-0.70.8-0.8
Water consumed over 24 hours0.30.52.00.00.4-0.10.00.2-0.5-1.10.90.7-0.7-0.60.1-1.41.4
Number of responses in last shaping day0.60.82.41.20.6-1.01.01.0-0.50.40.5-0.71.51.2-1.1-0.40.4