Hub : Genes

Vwa7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Vwa7 0.21 0.09 1.1e-10 0.09 0.11 0.09 0.1 1.4e-10 6.1e-12 3.3e-10 1.7e-11
2 pVTA gene expression Vwa7 0.31 0.1 0.0e+00 0.26 0.3 0.29 0.29 5.0e-21 3.7e-24 1.2e-23 3.5e-23
3 Adipose alternative TSS XM_063279117.1 0.03 0.02 5.4e-03 -0 0 -0 -0 6.9e-01 7.7e-02 9.6e-01 8.2e-01
4 PL gene expression Vwa7 0.05 0.03 4.3e-04 0.01 0.03 0.02 0.02 1.7e-02 3.1e-04 1.5e-03 1.7e-03
5 Brain alternative polyA XM_063279118.1 0.06 0.04 5.0e-05 0.04 0.03 0.03 0.03 7.8e-05 6.2e-04 1.7e-03 8.4e-04
6 pVTA alternative polyA NM_212499.2 0.06 0.03 3.0e-04 0.02 0.03 0.03 0.03 8.1e-03 1.5e-03 2.7e-03 1.1e-03
7 Eye gene expression Vwa7 0.62 0.15 2.9e-04 0.2 0.11 0.22 0.21 5.1e-04 8.2e-03 3.1e-04 3.4e-04
8 Brain intron excision ratio chr20_3809702_3809991 0.09 0.09 8.9e-03 0.01 -0 -0 0 4.7e-02 4.9e-01 5.7e-01 3.3e-01
9 Brain intron excision ratio chr20_3802232_3802461 0.05 0.04 3.8e-03 0.01 0 -0 0 1.5e-02 2.7e-01 5.2e-01 1.5e-01
10 Brain gene expression Vwa7 0.34 0.13 0.0e+00 0.27 0.28 0.28 0.28 7.0e-25 8.4e-26 1.6e-26 1.1e-25
11 Brain alternative polyA XM_039098675.2 0.04 0.02 3.5e-03 0.01 0.01 -0 0 8.3e-02 3.0e-02 3.9e-01 1.2e-01
12 Adipose alternative TSS NM_212499.2 0.03 0.02 8.3e-03 0 0.01 0.03 0.01 9.5e-02 1.9e-02 2.8e-04 6.7e-02
13 NAcc gene expression Vwa7 0.03 0.02 9.7e-05 0.03 0.03 0.03 0.03 3.3e-05 6.2e-05 3.2e-05 8.8e-05
14 pVTA isoform ratio XR_010060676.1 0.07 0.04 4.6e-04 0.05 0.04 0.04 0.04 1.0e-04 2.4e-04 3.2e-04 3.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.91.63.31.81.40.21.40.5-1.6-1.71.71.70.21.1-0.0-1.4-0.3
Area under the delay curve0.20.30.9-0.5-0.6-0.2-0.6-0.20.90.5-0.8-0.80.4-0.1-0.00.20.6
BMI with tail1.34.611.22.02.12.32.6-2.6-1.9-1.41.31.3-2.8-2.41.2-1.0-3.3
BMI without tail0.84.512.01.11.52.81.6-3.5-1.2-0.90.70.7-3.2-3.32.1-1.2-2.5
Body weight1.04.216.5-0.00.62.11.2-3.40.00.2-0.9-0.9-3.3-4.11.00.7-3.3
Weight adjusted by age0.41.15.1-1.2-0.30.7-0.3-1.00.41.2-0.8-0.8-1.3-2.30.30.9-1.4
Bone surface0.10.10.4-0.3-0.4-0.3-0.2-0.00.40.6-0.4-0.40.10.0-0.20.5-0.0
Bone volume0.10.30.50.70.60.40.7-0.4-0.6-0.30.50.5-0.3-0.10.3-0.4-0.6
Breakpoint value in progressive ratio session0.10.20.4-0.3-0.6-0.6-0.60.70.30.3-0.0-0.00.60.6-0.2-0.00.5
Number of licking bursts1.03.04.9-1.7-2.0-1.8-1.81.31.92.2-1.8-1.81.61.1-1.21.81.7
Context. condit. distance diff. score4.45.49.6-1.9-2.1-3.1-2.13.12.01.6-1.8-1.82.82.6-2.82.11.9
Locomotion velocity, session 10.80.92.1-1.2-1.1-1.1-1.51.10.90.5-0.7-0.71.31.0-0.40.51.1
Locomotion distance, session 10.50.61.40.80.6-0.30.51.1-0.8-1.01.01.00.71.2-0.3-0.70.2
Locomotion velocity, session 20.70.81.6-0.7-1.0-1.1-1.01.10.70.8-0.7-0.71.31.1-0.70.61.0
Locomotion distance, session 20.60.83.00.3-0.1-1.1-0.01.7-0.1-0.40.30.31.31.5-1.50.10.5
Locomotion velocity, session 30.50.51.60.50.70.80.4-0.5-0.8-0.80.90.9-0.3-0.31.3-1.0-0.3
Locomotion distance, session 30.60.72.60.40.2-0.6-0.11.4-0.4-0.70.80.81.31.6-0.5-0.61.0
Stereotopy head waving bouts, day 31.11.32.7-1.5-1.4-0.6-1.2-0.21.61.4-1.6-1.60.1-0.6-0.21.40.7
Stereotopy head waving duration, day 30.70.91.6-1.2-1.00.1-1.0-0.81.20.9-1.3-1.3-0.5-1.10.60.80.4
Locomotion velocity, session 71.71.96.90.70.2-1.50.22.6-0.4-0.60.70.72.02.5-2.0-0.21.0
Locomotion distance, session 71.82.38.60.70.2-1.5-0.12.6-0.5-1.01.01.02.22.9-1.6-0.61.6
Stereotopy head waving bouts, day 70.30.42.0-0.7-0.70.2-0.9-0.40.50.3-0.4-0.40.2-0.11.4-0.20.8
Stereotopy head waving duration, day 70.20.31.9-0.5-0.40.4-0.5-0.70.40.2-0.2-0.2-0.2-0.51.4-0.20.3
Locomotion velocity, session 86.27.59.8-3.1-3.1-2.9-3.12.33.12.9-2.8-2.82.61.6-2.42.82.5
Locomotion distance, session 83.75.313.9-1.3-1.7-3.2-1.63.71.51.1-1.2-1.23.13.0-3.61.91.6
Degree of sensitization distance1.01.11.6-1.0-1.2-1.2-1.00.81.21.2-1.3-1.30.80.6-1.11.30.6
Degree of sensitization stereotypy0.20.21.5-0.3-0.40.0-0.70.00.10.00.00.00.50.41.2-0.50.8
Conditioned locomotion0.30.41.0-0.5-0.4-0.1-0.0-0.40.60.8-0.7-0.7-0.5-0.7-0.61.0-0.7
Cocaine response after cond. corrected0.30.53.00.2-0.1-0.90.41.10.20.4-0.2-0.20.60.8-1.70.80.0
Cocaine response after cond. not corrected0.71.02.0-1.0-1.1-1.0-0.70.41.21.4-1.3-1.30.50.1-1.11.40.3
Cocaine response before conditioning1.61.93.3-1.8-1.30.5-1.5-1.81.41.5-1.7-1.7-0.8-1.81.60.80.1
Saline control response4.15.612.71.72.13.11.9-3.6-1.9-1.81.51.5-3.0-2.73.2-2.1-1.9
Bone: connectivity density0.50.71.61.30.9-0.11.00.6-1.0-1.01.11.10.20.9-0.7-0.6-0.4
Bone: cortical apparent density1.72.64.21.81.81.82.1-1.4-1.7-1.61.51.5-1.6-1.31.3-1.4-1.5
Bone: cortical area0.10.10.3-0.4-0.6-0.2-0.30.00.50.4-0.6-0.60.2-0.2-0.00.40.1
Bone: cortical porosity0.60.73.4-1.0-0.80.1-1.40.10.60.5-0.4-0.40.60.11.8-0.31.1
Bone: cortical porosity1.11.23.4-1.5-1.3-0.4-1.80.41.21.1-1.0-1.00.90.21.30.31.3
Bone: cortical thickness1.22.13.21.81.51.51.7-0.8-1.6-1.71.51.5-1.0-0.71.5-1.6-1.0
Bone: cortical thickness2.73.34.82.21.92.02.1-1.4-2.0-2.11.81.8-1.5-1.11.8-1.9-1.6
Bone: cortical tissue density1.52.33.71.71.71.81.9-1.4-1.6-1.41.41.4-1.6-1.31.3-1.3-1.5
Condit. Reinf. active minus inactive responses0.30.31.0-0.2-0.3-0.4-0.70.8-0.0-0.30.30.31.01.00.5-0.60.7
Condit. Reinf. active-inactive response ratio0.40.42.10.50.40.80.3-0.4-0.6-0.40.60.6-0.3-0.31.5-1.0-0.3
Condit. Reinf. active responses0.40.51.20.40.3-0.3-0.10.9-0.6-1.00.80.80.91.1-0.1-0.80.4
Condit. Reinf. inactive responses1.11.43.51.41.1-0.10.91.0-1.3-1.91.61.60.71.4-0.8-1.30.3
Incentive salience index mean1.62.04.8-1.0-1.3-1.9-1.42.10.90.5-0.6-0.62.22.0-1.50.71.4
Condit. Reinf. lever presses3.14.712.3-1.4-1.8-2.9-1.63.01.61.1-1.2-1.22.72.5-3.51.91.7
Condit. Reinf. active minus inactive responses0.30.41.1-0.8-0.40.4-0.6-0.80.50.8-0.7-0.7-0.5-1.00.90.3-0.1
Condit. Reinf. active-inactive response ratio0.81.33.3-1.5-1.1-0.1-1.2-0.61.21.8-1.6-1.6-0.2-1.00.71.10.2
Condit. Reinf. active responses0.10.10.5-0.30.00.5-0.2-0.50.0-0.10.00.0-0.4-0.60.7-0.2-0.1
Condit. Reinf. inactive responses0.60.92.51.00.90.80.9-0.4-0.9-1.61.21.2-0.6-0.20.5-1.1-0.6
Condit. Reinf. lever presses0.10.10.4-0.20.10.1-0.40.3-0.2-0.40.40.40.20.30.6-0.50.1
Condit. Reinf. lever reinforcers received0.10.10.4-0.5-0.20.2-0.5-0.30.20.1-0.1-0.1-0.1-0.40.7-0.10.2
Conditioned reinforcement - actives0.10.51.90.60.70.60.5-0.5-0.6-0.51.41.4-0.9-0.3-0.2-0.7-0.2
Conditioned reinforcement - inactives0.10.30.70.40.60.70.3-0.4-0.4-0.50.80.8-0.7-0.60.4-0.6-0.4
Conditioned locomotion0.10.10.2-0.30.10.1-0.10.20.10.40.40.4-0.3-0.2-0.40.4-0.3
Patch foraging indifference point 0 sec1.23.36.11.51.72.41.6-2.5-1.4-1.81.31.3-2.4-2.11.8-1.7-1.6
Patch foraging indifference point AUC0.10.20.5-0.6-0.7-0.1-0.7-0.30.60.6-0.5-0.50.2-0.00.50.10.7
Delay disc. indifference point, 0s delay0.80.92.1-0.9-1.0-1.0-0.80.61.30.8-1.1-1.10.80.5-1.51.00.6
Delay disc. indifference point, 16s delay0.20.20.60.60.60.70.5-0.6-0.3-0.30.30.3-0.3-0.30.7-0.8-0.3
Delay disc. indifference point, 2s delay1.31.43.1-1.6-1.4-0.7-1.5-0.21.71.2-1.6-1.60.4-0.3-0.50.91.2
Delay disc. indifference point, 24s delay0.20.21.4-0.4-0.10.5-0.4-0.50.40.4-0.5-0.5-0.1-0.61.2-0.1-0.2
Delay disc. indifference point, 4s delay0.50.51.1-0.8-0.70.1-0.6-1.10.90.9-0.9-0.9-0.4-0.80.50.30.1
Delay disc. indifference point, 8s delay0.10.20.8-0.3-0.4-0.3-0.40.30.70.3-0.4-0.40.70.4-0.20.20.9
Indifference point function ln k0.41.11.6-1.1-1.3-1.2-1.31.21.20.7-0.9-0.91.20.9-0.70.91.2
Indifference point function log k0.41.11.6-1.1-1.3-1.2-1.31.21.20.7-0.9-0.91.20.9-0.70.91.2
Patch foraging total patch changes 0 sec1.23.66.41.61.82.51.7-2.5-1.5-1.91.41.4-2.4-2.11.9-1.8-1.6
Patch foraging total patch changes 12 sec1.52.14.41.21.31.91.3-2.1-1.1-1.31.11.1-1.8-1.51.6-1.3-1.1
Patch foraging total patch changes 18 sec2.25.38.12.82.62.52.8-2.1-2.4-2.52.32.3-2.1-1.41.5-2.4-1.7
Patch foraging total patch changes 24 sec1.03.56.52.32.21.72.1-1.0-2.2-2.62.22.2-1.2-0.31.3-2.2-1.2
Patch foraging total patch changes 6 sec2.13.66.11.61.82.31.7-2.5-1.7-2.11.61.6-2.2-1.71.8-1.8-1.7
Patch foraging time to switch 0 sec0.51.94.21.71.71.02.0-0.6-1.5-1.41.31.3-1.3-0.8-0.2-0.7-2.0
Patch foraging water rate 0 sec0.00.10.3-0.2-0.20.2-0.1-0.50.30.2-0.5-0.5-0.2-0.50.40.2-0.2
Patch foraging water rate 12 sec0.10.61.41.20.90.60.90.1-1.0-0.60.90.9-0.20.20.7-1.0-0.1
Patch foraging water rate 18 sec0.10.31.00.40.50.70.5-0.5-0.4-0.30.20.2-0.6-0.61.0-0.3-0.6
Patch foraging water rate 24 sec0.20.30.90.60.60.70.7-0.6-0.5-0.40.50.5-0.6-0.40.9-0.5-0.3
Patch foraging water rate 6 sec0.10.20.50.70.50.50.6-0.2-0.5-0.50.40.4-0.1-0.10.4-0.50.1
Seeking ratio, delayed vs. immediate footshock0.30.42.00.0-0.10.80.0-1.10.60.3-0.1-0.1-0.5-0.81.4-0.50.6
Distance traveled before self-admin0.10.20.7-0.2-0.2-0.30.20.00.00.6-0.7-0.70.0-0.3-0.80.8-0.5
Distance traveled after self-admin0.30.51.7-0.5-0.40.5-0.1-1.30.30.7-0.7-0.7-0.9-1.31.00.3-0.5
Extensor digitorum longus weight0.20.92.2-1.1-1.0-0.8-0.90.41.10.9-1.2-1.20.2-0.1-1.51.20.0
Bone: elastic displacement0.50.61.50.80.80.80.5-0.0-0.9-1.10.90.9-0.2-0.11.1-1.20.0
Bone: elastic work0.10.10.30.20.30.50.2-0.2-0.3-0.40.10.1-0.3-0.50.4-0.4-0.2
Bone: endosteal estimation2.66.312.7-3.4-2.7-1.1-2.5-0.93.13.6-3.5-3.5-0.3-1.7-1.13.20.2
Bone: endosteal perimeter2.56.210.3-3.1-3.0-2.1-2.60.73.13.2-3.2-3.21.1-0.0-2.23.11.1
Epididymis fat weight5.628.442.66.46.35.66.5-4.2-5.9-5.75.25.2-5.2-3.53.4-5.0-5.4
Delta time in closed arm before/after self-admin0.20.20.9-0.20.00.10.2-0.50.20.4-0.1-0.1-0.8-0.8-0.20.4-1.0
Delta time in open arm before/after self-admin0.40.50.80.70.80.70.5-0.7-0.9-0.90.60.6-0.6-0.40.7-0.7-0.2
Diff in mean of infusions in LGA sessions0.71.24.20.3-0.4-1.4-0.11.70.40.10.40.41.52.0-1.9-0.01.1
Delay discount exponential model param0.20.30.90.60.70.10.70.3-0.9-0.60.80.8-0.30.2-0.2-0.2-0.6
Extinction: sum of active levers before priming0.71.12.2-1.1-1.2-1.2-1.10.71.31.4-0.4-0.40.90.8-1.50.90.9
Active lever presses in extinction session 60.60.61.80.70.80.60.5-0.1-1.0-1.31.01.0-0.3-0.10.6-0.9-0.9
Bone: final force1.01.63.71.01.01.51.4-1.8-0.8-0.70.30.3-1.8-1.81.0-0.5-1.9
Bone: final moment0.91.43.20.91.01.41.3-1.7-0.8-0.70.30.3-1.7-1.81.0-0.5-1.8
Food consumed during 24 hour testing period0.30.61.9-0.6-0.6-0.5-0.2-0.10.80.7-1.0-1.0-0.1-0.5-1.41.2-0.3
Glucose6.410.115.0-3.9-3.6-3.3-3.72.53.63.2-3.5-3.52.71.4-2.73.52.3
Heart weight0.71.23.3-1.3-0.70.6-0.9-1.81.10.8-1.1-1.1-0.9-1.81.20.70.0
Delay discount hyperbolic model param0.30.41.10.70.80.10.80.4-1.0-0.60.90.9-0.30.2-0.2-0.2-0.7
Intermittent access intake day 1-15 change0.00.21.00.4-0.00.20.1-0.6-0.5-1.00.60.6-0.30.1-0.0-0.50.2
Intermittent access intake escalation0.21.13.11.10.71.00.6-1.1-1.2-1.81.21.2-0.8-0.20.7-1.4-0.0
Intermittent access intake escalation 20.10.10.4-0.1-0.4-0.2-0.5-0.0-0.2-0.60.10.10.10.4-0.3-0.20.5
Intermitt. access day 1 inactive lever presses0.22.44.7-1.8-1.7-1.6-1.40.92.12.2-1.7-1.70.70.3-1.81.80.6
Intermitt. access day 15 inactive lever presses0.00.20.8-0.4-0.10.2-0.1-0.80.00.2-0.3-0.3-0.5-0.80.20.2-0.9
Intermitt. access escalation Index0.51.43.4-0.2-0.9-1.7-0.61.70.5-0.0-0.2-0.21.81.9-1.80.71.5
Intermittent access day 1 total infusions0.20.51.40.40.5-0.2-0.00.8-1.0-0.61.21.20.40.9-0.4-0.70.1
Intermittent access day 15 total infusions0.51.12.81.10.90.70.6-0.6-1.5-1.51.71.7-0.50.30.4-1.50.0
Intermittent access terminal intake (last 3 days)0.40.71.40.50.70.80.2-0.7-1.2-1.01.21.2-0.7-0.20.7-1.1-0.2
Intermittent access total infusions0.50.61.70.60.90.60.3-0.3-1.0-0.81.31.3-0.40.10.4-1.0-0.0
Intermittent access day 1 locomotion0.30.61.50.81.00.50.8-0.2-1.2-0.71.21.2-0.5-0.0-0.2-0.5-1.0
Intermittent access day 15 total locomotion0.10.51.40.40.50.80.6-1.2-0.8-0.30.50.5-1.2-0.9-0.1-0.3-0.8
Intermittent access total locomotion0.70.81.60.81.01.00.8-0.9-1.1-0.41.21.2-1.3-0.60.3-0.7-1.0
Intermittent access standard deviation0.52.45.51.01.31.91.3-2.2-1.3-1.00.90.9-2.3-2.01.3-0.9-1.9
Left kidney weight0.75.616.70.81.42.91.8-3.8-0.9-0.60.30.3-3.6-4.12.4-0.4-3.6
Right kidney weight0.74.815.50.81.32.61.9-3.5-0.8-0.50.20.2-3.5-3.91.5-0.1-3.4
Cocaine induced anxiety0.20.40.7-0.6-0.8-0.8-0.40.50.70.4-0.9-0.90.60.4-0.80.8-0.0
Post-drug Anxiety0.20.20.7-0.4-0.4-0.2-0.2-0.50.60.6-0.8-0.8-0.3-0.3-0.50.60.1
Baseline Anxiety0.10.10.3-0.10.10.40.1-0.5-0.00.4-0.1-0.1-0.6-0.5-0.2-0.00.4
Tail length0.84.59.0-3.0-2.30.0-2.3-1.72.72.3-2.9-2.9-0.8-2.40.42.00.3
Length with tail1.25.210.2-2.9-2.20.0-1.8-1.92.72.5-3.2-3.2-1.4-3.0-0.32.6-0.6
Length without tail0.62.98.2-1.3-0.80.30.0-1.71.31.6-2.1-2.1-1.7-2.9-0.82.4-2.4
Times rat made contact with spout1.92.15.41.71.31.01.0-0.1-1.6-2.22.02.00.10.71.4-2.30.3
Lifetime Intake0.40.51.40.50.80.60.3-0.4-0.9-0.71.21.2-0.5-0.10.3-0.8-0.0
Liver weight, left1.62.75.5-2.2-1.9-1.1-1.50.11.92.0-2.3-2.30.2-0.8-1.02.4-0.8
Liver weight, right2.34.07.8-2.6-2.4-1.6-2.20.22.42.2-2.8-2.80.6-0.5-1.72.6-0.0
Locomotor activity0.71.02.7-1.3-1.10.0-1.1-0.71.31.7-1.3-1.3-0.3-0.90.50.80.5
Locomotor testing distance0.30.71.7-1.1-0.8-0.2-0.8-0.51.01.3-1.1-1.1-0.2-0.7-0.40.90.2
Locomotor testing rearing0.20.61.3-0.6-0.40.1-0.2-0.90.60.9-1.0-1.0-0.9-1.1-0.60.9-0.6
Locomotion in novel chamber0.10.10.30.30.20.20.3-0.5-0.0-0.3-0.3-0.3-0.5-0.20.0-0.10.0
Locomotion in novel chamber post-restriction0.30.82.50.50.81.21.0-1.4-0.6-0.3-0.2-0.2-1.2-1.60.6-0.4-0.6
Fecal boli incidents, locomotor time 10.10.20.70.50.80.30.6-0.2-0.2-0.50.30.3-0.5-0.3-0.5-0.3-0.2
Change in fecal boli incidents, locomotor task1.71.83.3-1.7-1.7-1.1-1.30.41.51.5-1.8-1.80.6-0.0-1.21.80.9
Time >=10cm from walls, locomotor time 10.91.12.6-0.9-0.8-0.3-0.1-0.30.91.3-1.6-1.6-0.6-1.3-1.21.2-0.8
Bouts of movement, locomotor time 10.30.41.60.1-0.4-0.7-0.21.3-0.00.30.00.01.21.1-0.20.00.7
Total resting periods, locomotor time 10.30.41.5-0.2-0.5-0.7-0.41.20.10.4-0.1-0.11.20.9-0.30.20.6
Rest time, locomotor task time 10.20.30.7-0.7-0.6-0.4-0.80.40.90.2-0.5-0.50.2-0.1-0.40.40.8
Distance moved, locomotor task time 10.10.20.40.20.20.50.4-0.6-0.40.00.20.2-0.4-0.50.5-0.2-0.6
Vertical activity count, locomotor time 10.10.81.51.00.80.91.2-1.2-0.8-0.40.70.7-1.0-0.80.8-0.6-0.9
Time >=10cm from walls, locomotor time 20.41.22.9-1.4-0.9-0.3-0.6-0.51.41.6-1.7-1.7-0.3-1.2-0.71.2-0.0
Bouts of movement, locomotor time 20.10.21.0-0.3-0.6-0.1-0.6-0.00.40.0-0.8-0.80.20.11.00.00.1
Total resting periods, locomotor time 20.20.71.8-0.8-1.1-0.6-1.20.40.90.3-1.3-1.30.60.30.70.40.7
Rest time, locomotor task time 21.22.04.1-1.2-1.5-1.7-1.21.61.11.3-1.6-1.61.10.7-2.01.80.9
Distance moved, locomotor task time 21.11.42.40.81.31.41.3-1.5-1.0-0.91.01.0-1.2-1.11.3-1.0-1.5
Vertical activity count, locomotor time 20.30.81.90.50.91.01.0-1.4-0.4-0.20.70.7-1.1-1.10.9-0.6-1.0
Light reinforcement 10.10.41.30.80.50.41.1-0.9-0.2-0.80.40.4-0.7-0.5-0.30.0-0.8
Light reinforcement 20.10.20.9-0.1-0.1-0.20.3-0.30.20.1-0.4-0.4-0.3-0.3-0.90.7-0.9
Bone: marrow area2.56.011.9-3.3-2.6-0.9-2.3-1.13.03.4-3.4-3.4-0.5-1.9-1.03.10.0
Bone: maximum diameter2.24.46.6-2.4-2.5-2.1-2.31.22.42.6-2.4-2.41.70.8-1.72.31.4
Bone: maximum force0.40.82.60.50.61.00.9-1.3-0.5-0.40.10.1-1.4-1.50.5-0.1-1.6
Bone: maximum moment0.30.72.10.30.50.90.7-1.2-0.3-0.3-0.0-0.0-1.2-1.40.5-0.1-1.4
Mean time between licks in bursts0.74.25.6-2.2-2.3-2.2-2.41.62.32.0-2.2-2.31.81.2-1.72.11.9
Mean num. licks in bursts1.95.19.42.42.52.32.1-1.4-2.6-3.12.72.7-1.5-0.81.9-2.8-1.4
Cd content in liver1.01.12.21.31.40.71.5-0.1-1.3-1.31.11.1-0.6-0.3-0.4-0.7-1.3
Co content in liver1.31.53.11.11.31.51.5-1.3-1.2-0.80.80.8-1.6-1.50.9-0.7-1.8
Cu content in liver1.62.04.21.61.30.81.10.6-1.7-1.92.02.00.30.91.0-2.10.2
Fe content in liver1.41.72.41.41.51.51.5-1.4-1.4-1.11.01.0-1.5-1.21.0-1.1-1.6
K content in liver0.30.31.50.1-0.2-0.7-0.21.20.0-0.20.10.10.81.1-0.70.10.3
Mg content in liver3.03.35.3-1.7-1.9-2.3-1.82.21.81.5-1.5-1.52.01.8-2.01.81.3
Mn content in liver4.65.17.9-2.3-2.4-2.6-2.22.22.42.3-2.3-2.32.01.2-2.82.61.4
Na content in liver0.20.30.70.60.20.20.20.0-0.4-0.60.70.70.30.60.6-0.80.6
Rb content in liver0.10.21.40.20.2-0.50.20.3-0.0-0.4-0.0-0.00.10.4-1.20.4-0.3
Se content in liver4.75.59.3-2.7-2.9-2.6-3.01.92.62.2-2.2-2.22.61.8-1.41.82.4
Sr content in liver0.30.30.5-0.4-0.20.0-0.2-0.40.40.7-0.7-0.7-0.5-0.7-0.10.7-0.6
Zn content in liver0.30.30.6-0.7-0.5-0.6-0.50.70.60.3-0.6-0.60.40.2-0.80.70.1
Bone: minimum diameter2.03.86.6-2.4-2.3-1.6-1.90.82.52.2-2.6-2.60.9-0.2-1.92.50.8
Time in familiar zone, hab. session 12.83.07.22.11.91.21.50.1-2.1-2.72.42.4-0.20.71.0-2.50.1
Time in novel zone, hab. session 11.82.04.4-1.8-1.5-0.6-1.2-0.71.72.1-1.9-1.9-0.2-1.0-0.41.9-0.3
Total zone transitions, hab. session 10.20.30.9-0.1-0.3-0.7-0.30.90.2-0.40.00.00.80.9-0.90.10.6
Total locomotion distance, hab. session 10.20.31.30.1-0.1-0.7-0.10.90.0-0.70.10.10.70.9-1.10.10.5
Locomotion velocity, hab. session 10.10.20.6-0.0-0.2-0.6-0.20.70.1-0.6-0.0-0.00.50.7-0.80.10.4
Time in familiar zone, hab. session 20.91.01.91.41.01.01.2-0.5-1.1-1.21.11.1-0.7-0.20.9-1.3-0.6
Time in novel zone, hab. session 20.10.20.5-0.7-0.3-0.0-0.5-0.50.40.5-0.4-0.4-0.1-0.40.30.4-0.0
Total zone transitions, hab. session 20.10.20.90.50.1-0.30.50.5-0.1-0.30.30.30.20.4-1.00.10.1
Total locomotion distance, hab. session 20.40.62.80.70.2-0.80.51.1-0.2-0.70.40.40.61.2-1.70.10.3
Locomotion velocity, hab. session 20.70.94.10.4-0.1-1.20.21.50.1-0.50.20.21.11.6-2.00.30.7
Novel to familiar place preference ratio0.00.10.2-0.1-0.2-0.2-0.30.30.1-0.0-0.1-0.10.30.40.0-0.10.4
Novelty place preference0.10.10.3-0.3-0.4-0.2-0.50.10.20.2-0.3-0.30.30.30.20.00.5
Time in novel zone, NPP test0.10.10.3-0.4-0.4-0.1-0.6-0.10.30.3-0.4-0.40.20.10.40.00.5
Total zone transitions, NPP test0.50.72.20.1-0.0-1.0-0.11.5-0.0-0.50.40.41.11.5-1.50.10.6
Total locomotion distance, NPP test0.50.72.90.70.5-0.80.61.2-0.5-0.90.60.60.61.2-1.70.0-0.1
Locomotion velocity, NPP test0.81.14.50.70.5-1.00.61.6-0.5-1.00.70.70.91.6-2.10.00.2
Intraocular pressure0.71.11.91.41.40.91.4-0.4-1.3-1.31.41.4-0.50.00.4-1.2-0.7
Delta distance traveled before/after self-admin0.60.73.3-0.5-0.20.9-0.5-1.50.50.2-0.1-0.1-1.0-1.31.8-0.40.0
Delta ambulatory time before/after self-admin0.30.62.5-0.7-0.50.5-0.7-1.10.80.4-0.5-0.5-0.7-1.01.6-0.10.2
Parametrial fat weight1.63.87.92.22.22.02.7-2.1-2.0-1.21.41.4-2.2-1.91.0-1.0-2.8
Pavlov. Cond. lever latency5.46.810.52.62.63.13.0-3.1-2.3-2.21.91.9-3.2-2.72.5-1.9-2.9
Pavlov. Cond. magazine entry latency3.03.96.7-2.0-2.2-2.1-2.52.21.91.5-1.5-1.52.52.0-0.91.12.6
Pavlov. Cond. change in total contacts2.12.23.8-1.7-1.7-1.5-2.01.41.51.6-1.3-1.31.81.2-0.70.91.9
Pavlov. Cond. index score5.36.710.6-2.5-2.8-3.0-3.03.12.42.1-2.0-2.03.32.6-2.11.83.0
Pavlov. Cond. latency score5.77.211.0-2.6-2.9-3.1-3.13.12.52.3-2.1-2.13.32.7-2.31.93.1
Pavlov. Cond. lever contacts5.36.49.4-2.5-2.5-3.1-2.73.02.32.2-2.0-2.03.02.4-2.82.22.4
Pavlov. Cond. magazine entry number2.02.54.21.61.81.72.0-1.9-1.5-1.21.21.2-2.1-1.60.8-0.9-2.0
Pavlov. Cond. intertrial magazine entries2.63.15.12.02.21.62.2-1.2-2.1-2.02.12.1-1.3-0.70.8-1.7-1.5
Pavlov. Cond. lever-magazine prob. diff.5.16.310.4-2.4-2.6-2.9-2.93.12.31.9-1.9-1.93.22.6-2.01.72.9
Pavlov. Cond. response bias3.64.57.5-2.1-2.3-2.5-2.52.62.01.6-1.6-1.62.72.2-1.71.52.4
Pavlov. Cond. lever latency0.60.82.0-0.7-0.9-0.9-0.50.21.10.9-1.1-1.10.40.0-1.41.30.6
Pavlov. Cond. magazine entry latency0.20.30.4-0.5-0.5-0.5-0.70.50.40.6-0.6-0.60.50.4-0.30.40.4
Pavlov. Cond. change in total contacts0.10.32.10.10.40.7-0.0-0.4-0.40.00.40.4-0.4-0.31.5-0.7-0.2
Pavlov. Cond. index score0.00.10.4-0.10.00.2-0.30.1-0.2-0.00.10.10.10.10.6-0.40.1
Pavlov. Cond. latency score0.10.10.60.00.20.4-0.1-0.1-0.3-0.10.20.2-0.2-0.10.8-0.5-0.1
Pavlov. Cond. lever contacts0.40.71.80.70.80.80.5-0.2-1.0-0.71.01.0-0.4-0.11.3-1.1-0.7
Pavlov. Cond. magazine entry number0.00.00.1-0.1-0.10.10.0-0.10.1-0.30.20.2-0.0-0.10.2-0.00.0
Pavlov. Cond. intertrial magazine entries0.61.32.0-1.2-1.4-1.4-1.41.11.30.8-0.8-0.81.41.1-0.80.81.3
Pavlov. Cond. lever-magazine prob. diff.0.00.10.3-0.00.10.2-0.20.1-0.2-0.10.20.20.00.10.6-0.40.0
Pavlov. Cond. response bias0.10.10.30.10.20.1-0.20.4-0.4-0.10.30.30.30.50.6-0.50.0
Time in closed arm before self-admin0.20.30.9-0.8-0.6-0.3-0.6-0.20.50.4-0.9-0.90.1-0.1-0.10.40.2
Time in closed arm after self-admin0.00.10.2-0.1-0.00.0-0.0-0.30.1-0.2-0.2-0.2-0.5-0.3-0.3-0.2-0.1
Time in open arm before self-admin0.50.61.5-0.7-0.7-0.6-1.01.00.70.5-0.2-0.21.10.9-0.10.11.2
Time in open arm after self-admin0.10.10.7-0.20.00.2-0.40.0-0.10.10.30.30.1-0.10.8-0.00.2
Bone: periosteal estimation1.22.95.9-2.2-1.9-0.5-1.6-0.92.12.4-2.4-2.4-0.4-1.5-0.52.10.0
Bone: periosteal perimeter1.32.54.3-2.0-2.0-1.2-1.80.52.12.1-2.1-2.10.8-0.1-1.01.80.9
Bone: post-yield work1.01.83.7-1.6-1.4-1.2-1.20.31.61.6-1.6-1.60.3-0.2-1.71.90.0
Progressive ratio test 1 active lever presses0.10.10.4-0.00.20.1-0.10.2-0.4-0.20.60.6-0.2-0.0-0.3-0.2-0.6
Progressive ratio test 1 breakpoint0.10.10.3-0.10.20.1-0.10.2-0.4-0.10.50.5-0.2-0.1-0.3-0.2-0.6
Progressive ratio test 1 inactive lever presses0.41.01.81.21.20.71.2-0.4-1.1-0.41.31.3-1.0-0.3-0.3-1.0-1.2
Progressive ratio test 2 active lever presses0.40.51.90.80.50.10.30.2-0.9-0.81.41.4-0.20.7-0.5-0.80.0
Progressive ratio test 2 breakpoint0.50.62.00.90.60.20.40.1-1.1-0.91.41.4-0.20.7-0.4-1.00.0
Progressive ratio test 2 inactive lever presses0.10.41.6-0.7-0.5-0.7-0.80.30.50.20.30.30.30.4-1.30.50.6
Incentive Sensitization - Responses0.10.41.00.4-0.1-0.4-0.20.4-0.5-0.50.70.70.31.0-0.8-0.61.0
Incentive Sensitization - Breakpoint0.20.41.00.70.1-0.30.00.3-0.7-0.70.90.90.21.0-0.7-0.70.8
Sum of active levers in priming session hrs 5-60.20.20.6-0.7-0.5-0.4-0.80.40.50.20.00.00.30.1-0.20.40.6
Progressive ratio1.13.37.71.21.32.41.7-2.7-1.2-1.10.40.4-2.6-2.82.3-0.6-2.0
Food seeking constrained by brief footshock0.20.30.70.50.60.60.3-0.9-0.5-0.30.20.2-0.7-0.30.9-0.6-0.6
Seeking ratio, punishment vs. effort1.02.34.8-1.2-1.3-1.9-1.72.11.31.3-0.6-0.62.02.2-1.60.41.7
Retroperitoneal fat weight0.20.81.71.21.10.71.3-0.6-1.0-1.00.70.7-0.9-0.4-0.3-0.6-1.2
Reaction time number correct0.82.94.51.51.82.11.8-1.9-1.6-1.11.31.3-1.9-1.72.1-1.3-1.9
Reaction time mean minus median0.42.34.2-1.2-1.5-1.9-1.62.01.10.8-0.9-0.91.91.8-2.01.11.5
Reaction time mean minus median AUC0.32.15.2-1.1-1.2-1.9-1.52.30.80.9-0.7-0.72.01.9-1.81.01.2
Reaction time num false alarms0.61.01.7-0.9-1.3-1.0-1.10.61.21.0-1.2-1.21.00.7-0.50.91.3
Reaction time num false alarms AUC0.61.42.6-1.2-1.6-1.0-1.40.51.51.4-1.4-1.41.00.6-0.21.01.5
Reaction time trials correct on left0.82.94.51.51.82.11.8-1.9-1.6-1.11.31.3-1.9-1.72.1-1.3-1.9
Reaction time trials on left0.82.74.41.41.72.11.7-1.9-1.5-1.11.21.2-1.9-1.72.1-1.3-1.9
Reaction time mean1.63.66.7-1.6-1.8-2.5-1.62.41.51.9-1.5-1.52.11.8-2.62.01.1
Reaction time mean AUC1.33.26.2-1.5-1.6-2.4-1.62.31.41.8-1.4-1.42.01.7-2.51.81.1
Median of all reaction times1.62.54.9-1.4-1.4-2.1-1.31.91.31.9-1.4-1.41.61.3-2.21.80.7
Reaction time omissions1.42.24.6-1.3-1.4-1.9-1.31.61.31.6-1.3-1.31.51.3-2.11.61.2
Reaction time false alarm rate3.04.26.5-2.1-2.5-2.2-2.41.52.32.0-2.0-2.02.11.5-1.31.72.5
Reaction time premature initiation rate0.20.30.9-0.30.30.40.2-0.8-0.10.1-0.1-0.1-0.8-1.00.00.4-0.9
Reaction time premature initiations0.61.74.00.51.21.61.2-1.9-0.9-0.50.60.6-1.9-2.01.2-0.4-2.0
Std. dev. reaction times1.24.15.9-2.1-2.2-2.4-2.32.31.91.8-1.7-1.72.31.8-2.11.81.9
Reaction time trials completed0.82.74.41.41.72.11.7-1.9-1.5-1.11.21.2-1.9-1.72.1-1.3-1.9
Reaction time trials AUC0.82.64.11.41.72.01.8-1.8-1.5-1.01.21.2-1.8-1.72.0-1.2-1.9
Run reversals in cocaine runway, females0.70.81.51.01.21.01.0-0.4-1.2-1.20.80.8-1.0-0.60.3-0.6-0.8
Run reversals in cocaine runway, males0.70.71.5-0.9-0.8-1.0-0.90.70.80.7-0.7-0.70.70.6-1.20.91.0
Latency to leave start box in cocaine runway1.11.52.5-1.0-1.2-1.6-1.01.11.41.0-1.3-1.31.51.1-1.61.01.1
Latency to leave start box in cocaine runway, F0.81.02.6-0.7-0.8-1.3-0.71.00.90.9-1.0-1.01.11.0-1.60.70.7
Latency to leave start box in cocaine runway, M0.40.40.8-0.6-0.7-0.7-0.50.30.90.4-0.7-0.70.80.2-0.30.60.7
Std. dev. time between licks in bursts3.26.09.5-2.9-2.8-2.3-2.81.22.93.1-3.0-3.01.60.7-1.72.91.6
Total sessions with >9 infusions0.20.20.80.20.40.5-0.0-0.1-0.6-0.50.90.9-0.3-0.20.4-0.60.1
Short access day 1 total inactive lever presses0.51.01.9-1.3-0.8-0.8-1.20.91.41.2-1.0-1.00.60.1-0.91.01.0
Short access day 10 total inactive lever presses0.10.41.50.2-0.5-1.0-0.10.80.40.2-0.3-0.30.50.9-1.20.10.5
Short access day 1 total infusions0.00.10.3-0.5-0.1-0.2-0.60.2-0.2-0.40.30.30.20.2-0.3-0.20.1
Short access day 10 total infusions0.20.41.00.80.90.40.5-0.0-0.9-0.61.01.0-0.20.20.3-0.7-0.3
Short access total infusions0.10.20.60.20.50.30.0-0.0-0.5-0.60.80.8-0.10.10.0-0.6-0.0
Short access day 1 locomotion0.30.51.7-0.1-0.4-1.0-0.41.2-0.00.30.40.40.81.3-1.30.30.6
Short access day 10 total locomotion0.31.33.3-1.5-1.3-0.2-1.0-0.80.91.8-1.5-1.5-0.6-1.2-0.41.4-0.4
Short access total locomotion0.30.41.4-0.8-0.6-0.4-0.50.20.51.2-0.6-0.6-0.1-0.3-0.91.0-0.2
One hour access (0.3 mA shock)0.80.93.50.5-0.2-1.0-0.10.9-0.3-0.50.90.90.91.9-1.5-0.31.5
Compulsive drug intake2.84.111.2-1.3-2.1-2.6-1.31.91.61.2-1.8-1.82.12.0-3.32.02.2
One hour access (shock baseline)0.82.14.51.61.61.31.1-0.8-1.8-1.42.12.1-0.9-0.11.2-1.9-0.5
Social response proportion0.70.81.8-1.3-0.9-0.3-0.9-0.11.11.3-1.2-1.2-0.2-0.9-0.61.1-0.2
Social responses0.50.61.3-1.1-0.9-0.1-0.9-0.41.11.1-0.9-0.9-0.1-0.8-0.10.80.3
Social time2.94.57.0-1.8-2.3-2.4-1.91.72.22.6-2.1-2.11.81.4-2.62.31.9
Soleus weight3.911.519.1-4.1-3.9-3.1-3.41.64.14.3-4.2-4.21.70.3-3.14.41.4
Bone: stiffness0.50.91.61.10.91.01.3-1.1-0.9-1.00.60.6-1.1-0.90.4-0.6-1.3
Tibialis anterior weight0.41.42.51.41.31.21.4-0.7-1.3-1.61.41.4-0.9-0.60.7-1.4-0.9
Time to tail flick, vehicle, before self-admin0.40.51.40.8-0.1-0.60.60.9-0.1-0.00.50.50.71.2-1.1-0.21.0
Time to tail flick, vehicle, after self-admin0.40.81.5-0.9-1.0-1.0-0.90.90.80.5-0.4-0.41.11.0-1.10.71.2
Time to tail flick, test, before self-admin0.20.20.90.60.20.40.3-0.3-0.7-0.80.40.40.00.40.4-0.90.3
Time to tail flick, test, after self-admin0.60.72.20.50.1-0.4-0.20.8-0.6-0.90.80.80.91.5-0.3-1.01.1
Delta time to tail flick, vehicle, before/after SA0.10.10.7-0.10.3-0.0-0.30.3-0.3-0.80.40.40.30.40.2-0.50.1
Delta time to tail flick, test, before/after SA0.30.40.90.80.6-0.10.50.7-0.7-0.60.90.90.20.5-0.3-0.4-0.2
Tibia length1.33.67.6-2.3-1.8-0.5-1.5-1.62.32.2-2.8-2.8-0.8-2.0-0.92.5-0.6
Ambulatory time before self-admin0.00.10.4-0.0-0.1-0.20.10.1-0.3-0.0-0.3-0.30.20.1-0.60.1-0.2
Ambulatory time after self-admin0.30.41.3-0.6-0.40.4-0.4-1.20.30.2-0.6-0.6-0.7-1.10.80.0-0.2
Bone: tissue strength0.20.21.10.20.50.40.5-0.5-0.5-0.30.30.3-0.6-0.6-0.1-0.1-1.0
Total heroin consumption0.10.10.3-0.5-0.5-0.4-0.50.30.10.1-0.4-0.40.30.2-0.10.2-0.1
Bone: trabecular number1.22.34.62.21.70.31.60.6-1.9-2.12.02.00.31.40.0-1.7-0.2
Bone: trabecular spacing1.31.94.2-1.9-1.4-0.0-1.2-0.81.62.1-1.9-1.9-0.5-1.60.21.6-0.1
Bone: trabecular thickness1.11.53.31.81.50.41.50.1-1.7-1.61.61.6-0.10.80.1-1.3-0.8
Bone: trabecular tissue density0.20.31.0-0.5-0.50.3-0.7-0.80.40.3-0.5-0.5-0.2-0.31.0-0.10.5
Water consumed over 24 hours0.30.50.9-0.8-0.9-0.8-0.80.50.80.7-0.8-0.80.70.3-0.70.80.4
Number of responses in last shaping day1.92.56.2-2.5-2.0-1.1-2.20.11.92.0-1.6-1.60.8-0.2-0.61.71.2