Hub : Genes

Vegfa

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS NM_001110335.1 0.06 0.04 5.6e-03 0 0.01 0.01 0 6.6e-02 2.4e-03 1.4e-02 1.5e-01
2 NAcc alternative TSS NM_031836.3 0.08 0.04 1.7e-03 0 0.02 0.01 0 8.3e-02 5.2e-04 1.7e-02 3.1e-01
3 LHb gene expression Vegfa 0.16 0.1 4.0e-03 0.03 0.07 0.08 0.04 8.5e-02 9.6e-03 5.6e-03 4.1e-02
4 NAcc mRNA stability Vegfa 0.03 0.02 2.2e-03 0 0.01 0 0 2.4e-01 1.3e-02 2.8e-01 1.2e-01
5 PL intron excision ratio chr9_22453933_22456824 0.03 0.02 6.6e-03 0.02 0.02 0.02 0.02 1.0e-03 4.1e-03 1.7e-03 3.7e-03
6 PL isoform ratio NM_001110336.1 0.02 0.01 5.7e-03 0.01 0.01 0.01 0.01 9.1e-03 1.9e-02 8.7e-03 3.0e-02
7 NAcc isoform ratio NM_001110336.1 0.01 0.01 6.4e-03 0.01 0.01 0.01 0.01 9.7e-03 8.4e-03 3.9e-02 3.7e-02
8 LHb isoform ratio NM_001110336.1 0.18 0.13 4.0e-03 0.14 0.09 0.06 0.08 4.4e-04 4.2e-03 1.3e-02 5.0e-03
9 LHb alternative TSS NM_001110335.1 0.23 0.17 4.0e-03 0.1 0.09 0.08 0.09 2.4e-03 3.4e-03 6.4e-03 3.6e-03
10 Brain isoform ratio NM_001287107.1 0.05 0.03 5.1e-05 0.03 0.04 0.03 0.03 7.5e-04 6.4e-05 3.5e-04 4.0e-04
11 Brain isoform ratio NM_031836.3 0.05 0.03 5.1e-05 0.03 0.04 0.03 0.03 7.5e-04 6.4e-05 3.5e-04 4.0e-04
12 LHb alternative TSS NM_031836.3 0.18 0.14 7.9e-03 0.08 0.07 0.04 0.07 7.4e-03 8.9e-03 5.1e-02 1.1e-02
13 Adipose gene expression Vegfa 0.19 0.08 0.0e+00 0.2 0.2 0.2 0.2 1.0e-21 5.6e-22 2.6e-22 3.7e-22
14 Liver mRNA stability Vegfa 0.02 0.01 8.4e-03 0.02 0.02 0.02 0.01 6.5e-03 3.6e-03 5.0e-03 4.5e-02
15 pVTA intron excision ratio chr9_22461091_22462800 0.03 0.02 2.5e-03 0.04 0.01 0.02 0.03 1.9e-04 2.1e-02 6.6e-03 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.50.92.2-0.91.10.40.90.80.90.71.01.0-1.2-1.2-0.30.80.2-1.5
Area under the delay curve2.42.74.71.3-1.5-0.6-0.91.8-2.1-1.3-2.2-2.21.61.61.2-1.6-2.11.9
BMI with tail0.41.413.90.3-0.4-0.3-1.1-3.70.70.30.50.50.00.0-1.00.31.90.0
BMI without tail1.23.716.81.1-1.10.80.2-4.12.01.71.71.7-1.4-1.4-2.21.73.1-1.3
Body weight1.67.115.61.2-1.01.81.6-3.93.12.72.92.9-2.6-2.6-3.32.73.7-2.1
Weight adjusted by age0.10.20.6-0.70.7-0.8-0.3-0.6-0.1-0.3-0.2-0.2-0.0-0.00.40.00.1-0.6
Bone surface0.61.15.7-1.82.0-0.10.52.4-0.4-0.1-0.3-0.3-0.4-0.40.3-0.1-1.2-0.7
Bone volume0.40.62.8-1.51.60.10.61.7-0.1-0.00.00.0-0.4-0.40.1-0.0-0.9-0.6
Breakpoint value in progressive ratio session0.91.11.8-0.50.4-1.3-0.71.0-1.2-1.2-1.1-1.11.21.20.9-1.3-1.40.9
Number of licking bursts0.71.22.0-0.70.90.60.9-1.11.01.20.80.8-1.4-1.4-1.21.21.3-1.3
Context. condit. distance diff. score0.81.04.8-1.61.6-1.4-0.8-2.20.3-0.10.20.2-0.2-0.2-0.10.21.1-0.7
Locomotion velocity, session 10.80.91.5-0.30.2-0.8-1.00.9-0.9-1.1-0.8-0.81.11.11.1-1.1-1.20.8
Locomotion distance, session 11.51.86.9-2.62.6-1.9-1.70.6-0.8-1.1-0.7-0.70.80.81.3-0.9-0.6-0.3
Locomotion velocity, session 20.40.42.7-0.50.6-0.8-1.2-1.60.3-0.20.20.20.10.10.20.10.8-0.5
Locomotion distance, session 20.81.12.9-1.61.6-1.1-1.70.1-0.7-1.1-0.8-0.80.90.91.1-0.9-0.50.1
Locomotion velocity, session 31.11.22.1-0.40.2-0.8-1.3-0.1-1.4-1.1-1.5-1.51.31.30.9-1.4-0.81.4
Locomotion distance, session 31.21.43.3-0.0-0.2-0.3-0.90.5-1.5-1.1-1.5-1.51.31.30.9-1.4-1.11.8
Stereotopy head waving bouts, day 30.20.20.40.3-0.30.20.6-0.40.60.60.60.6-0.6-0.6-0.30.50.5-0.4
Stereotopy head waving duration, day 30.10.11.00.1-0.0-0.4-0.3-1.00.2-0.00.20.20.00.00.10.00.40.0
Locomotion velocity, session 71.11.22.5-0.40.2-0.7-0.70.9-1.1-1.2-0.8-0.81.31.31.6-1.4-1.41.6
Locomotion distance, session 72.12.64.2-1.51.2-2.1-1.80.6-1.5-1.9-1.2-1.21.91.91.9-1.9-1.51.7
Stereotopy head waving bouts, day 70.60.63.1-0.20.30.40.2-1.70.70.60.50.5-0.8-0.8-0.60.91.1-0.9
Stereotopy head waving duration, day 70.40.40.9-0.20.40.50.5-1.00.70.60.50.5-0.8-0.8-0.50.80.8-0.9
Locomotion velocity, session 80.81.03.9-1.92.0-1.3-0.90.4-0.4-0.9-0.1-0.10.60.61.1-0.7-0.8-0.1
Locomotion distance, session 81.62.38.6-2.92.9-2.2-2.1-0.8-0.9-1.2-0.9-0.90.90.91.1-0.9-0.1-0.2
Degree of sensitization distance0.40.42.0-0.90.9-1.4-0.8-0.1-0.1-0.60.10.10.40.40.7-0.4-0.2-0.1
Degree of sensitization stereotypy0.20.21.1-0.60.70.1-0.3-1.10.00.1-0.3-0.3-0.3-0.3-0.00.30.5-0.5
Conditioned locomotion1.82.14.20.7-0.9-0.7-0.81.4-1.5-1.4-1.2-1.21.81.81.6-1.6-1.92.1
Cocaine response after cond. corrected0.10.20.50.7-0.70.70.6-0.30.30.30.10.1-0.3-0.3-0.30.20.1-0.0
Cocaine response after cond. not corrected0.10.10.70.9-0.80.40.5-0.1-0.10.0-0.2-0.2-0.0-0.0-0.10.0-0.20.2
Cocaine response before conditioning1.01.22.3-0.60.6-1.1-0.81.0-1.5-1.1-1.5-1.51.01.01.3-1.0-1.30.8
Saline control response0.10.20.5-0.40.4-0.3-0.30.5-0.5-0.5-0.4-0.40.40.40.2-0.4-0.70.1
Bone: connectivity density0.60.92.6-0.91.20.60.91.20.60.80.50.5-1.3-1.3-0.30.90.2-1.6
Bone: cortical apparent density0.10.20.60.8-0.80.10.50.60.30.10.50.5-0.1-0.10.00.3-0.1-0.1
Bone: cortical area0.61.02.1-1.51.3-0.8-0.61.0-1.0-0.9-0.9-0.90.80.80.8-1.1-0.91.0
Bone: cortical porosity0.20.30.60.7-0.70.50.3-0.60.30.6-0.0-0.0-0.5-0.5-0.60.50.8-0.1
Bone: cortical porosity0.10.10.40.6-0.60.1-0.2-0.5-0.10.1-0.3-0.30.10.1-0.1-0.10.40.5
Bone: cortical thickness0.30.51.1-0.80.7-0.7-0.80.2-0.8-0.6-1.1-1.10.60.60.7-0.8-0.20.8
Bone: cortical thickness0.20.20.6-0.40.50.20.40.70.30.30.60.6-0.4-0.4-0.20.3-0.0-0.5
Bone: cortical tissue density0.10.20.80.9-0.90.10.50.70.30.10.50.5-0.1-0.10.00.4-0.1-0.1
Condit. Reinf. active minus inactive responses2.12.37.6-2.82.7-1.6-1.21.1-1.4-1.3-1.4-1.40.90.91.4-1.2-1.10.3
Condit. Reinf. active-inactive response ratio0.40.42.6-1.61.6-0.8-0.30.3-0.2-0.4-0.1-0.10.10.10.4-0.1-0.2-0.4
Condit. Reinf. active responses1.62.08.3-2.92.9-1.6-1.10.4-1.3-1.0-1.5-1.50.60.61.0-0.9-0.60.0
Condit. Reinf. inactive responses0.20.31.0-0.70.8-0.3-0.1-1.0-0.30.2-0.7-0.7-0.4-0.4-0.40.20.6-0.3
Incentive salience index mean1.72.16.1-2.52.4-1.8-1.30.7-1.4-1.3-1.4-1.41.01.01.3-1.2-0.90.5
Condit. Reinf. lever presses0.30.51.6-1.21.3-1.1-0.7-0.6-0.5-0.3-0.8-0.80.10.10.3-0.20.2-0.3
Condit. Reinf. active minus inactive responses2.12.711.7-3.43.4-2.0-1.60.7-0.9-1.3-0.6-0.60.90.91.6-1.2-0.9-0.3
Condit. Reinf. active-inactive response ratio1.92.212.8-3.53.6-1.8-1.3-0.2-0.3-0.9-0.0-0.00.40.41.0-0.7-0.3-0.7
Condit. Reinf. active responses1.92.78.6-2.92.9-1.9-1.81.3-1.1-1.5-0.9-0.91.21.21.7-1.4-1.4-0.0
Condit. Reinf. inactive responses0.50.62.1-0.20.1-0.3-0.71.5-0.8-0.8-0.7-0.70.80.80.7-0.8-1.20.5
Condit. Reinf. lever presses1.31.89.0-2.93.0-1.9-1.40.1-0.4-0.8-0.3-0.30.40.41.1-0.6-0.4-1.0
Condit. Reinf. lever reinforcers received2.02.89.0-3.03.0-2.0-1.81.3-1.2-1.5-0.9-0.91.21.21.7-1.4-1.4-0.1
Conditioned reinforcement - actives0.91.63.6-0.30.2-1.4-1.4-0.5-1.2-1.6-1.2-1.21.51.51.9-1.2-0.91.4
Conditioned reinforcement - inactives0.60.92.2-1.21.2-1.5-1.5-0.3-0.7-1.0-0.8-0.80.80.81.5-0.7-0.20.4
Conditioned locomotion0.10.10.3-0.50.5-0.5-0.2-0.00.2-0.20.30.30.10.10.4-0.00.1-0.1
Patch foraging indifference point 0 sec0.10.21.2-0.00.1-0.3-0.3-1.10.40.20.20.2-0.3-0.30.00.50.7-0.6
Patch foraging indifference point AUC3.44.97.4-1.91.7-2.5-2.71.1-2.3-2.4-2.4-2.42.42.42.6-2.3-1.71.9
Delay disc. indifference point, 0s delay5.96.59.2-2.32.1-2.5-2.61.8-2.7-2.9-2.4-2.42.72.73.0-2.7-2.62.1
Delay disc. indifference point, 16s delay1.82.010.33.1-3.21.00.71.6-0.8-0.0-0.9-0.90.60.6-0.2-0.4-1.21.2
Delay disc. indifference point, 2s delay2.02.23.30.3-0.5-0.5-1.21.5-1.8-1.5-1.8-1.81.71.71.5-1.6-1.71.8
Delay disc. indifference point, 24s delay0.20.20.70.8-0.70.30.10.0-0.00.4-0.3-0.3-0.4-0.4-0.60.50.2-0.4
Delay disc. indifference point, 4s delay3.53.75.50.9-1.2-1.4-1.61.5-2.2-1.9-2.1-2.12.32.32.0-2.2-2.12.3
Delay disc. indifference point, 8s delay2.02.44.60.6-0.7-0.7-0.81.7-2.1-1.3-2.1-2.11.41.41.3-1.5-2.11.6
Indifference point function ln k1.52.68.32.9-2.91.81.6-1.51.41.31.41.4-1.0-1.0-1.51.21.2-0.3
Indifference point function log k1.52.68.32.9-2.91.81.6-1.51.41.31.41.4-1.0-1.0-1.51.21.2-0.3
Patch foraging total patch changes 0 sec0.10.21.1-0.20.2-0.5-0.5-1.00.30.10.20.2-0.1-0.10.10.30.6-0.5
Patch foraging total patch changes 12 sec0.70.92.4-0.70.6-1.1-1.5-0.5-0.9-1.0-1.0-1.01.11.10.8-1.0-0.30.9
Patch foraging total patch changes 18 sec0.81.32.0-0.90.9-0.8-1.30.5-1.2-1.3-1.4-1.41.11.11.4-1.2-1.01.0
Patch foraging total patch changes 24 sec0.50.92.6-1.00.9-1.3-1.6-0.4-0.9-1.0-0.9-0.91.11.10.8-0.9-0.40.6
Patch foraging total patch changes 6 sec0.40.61.9-1.21.2-1.4-1.2-1.1-0.3-0.4-0.4-0.40.30.30.3-0.10.5-0.2
Patch foraging time to switch 0 sec1.53.17.82.0-1.82.62.81.11.02.01.01.0-2.0-2.0-2.01.70.3-1.3
Patch foraging water rate 0 sec2.04.28.1-1.20.9-2.3-2.9-1.1-1.6-2.5-1.5-1.52.72.72.2-2.5-1.12.4
Patch foraging water rate 12 sec2.04.110.2-3.23.0-2.7-3.0-3.0-0.8-2.0-0.6-0.61.81.81.2-1.70.21.1
Patch foraging water rate 18 sec0.30.44.3-0.1-0.0-0.3-0.7-2.10.3-0.30.30.30.50.5-0.3-0.40.60.6
Patch foraging water rate 24 sec0.50.74.5-0.30.1-0.6-0.9-2.10.5-0.60.70.70.90.9-0.0-0.70.60.9
Patch foraging water rate 6 sec2.53.75.9-1.91.5-2.0-2.3-0.3-1.6-2.3-1.3-1.32.42.41.9-2.4-1.42.3
Seeking ratio, delayed vs. immediate footshock0.10.20.50.3-0.20.70.2-0.70.50.30.30.3-0.4-0.4-0.20.60.3-0.5
Distance traveled before self-admin0.60.82.61.6-1.60.90.5-1.50.70.70.60.6-0.4-0.4-0.50.61.10.4
Distance traveled after self-admin0.20.31.5-0.60.6-0.5-0.5-1.2-0.3-0.5-0.4-0.40.40.40.4-0.40.10.6
Extensor digitorum longus weight0.10.33.1-0.20.1-0.1-0.2-1.80.0-0.10.00.00.20.2-0.2-0.10.50.5
Bone: elastic displacement0.91.13.31.8-1.81.31.40.00.71.10.60.6-0.8-0.8-1.00.80.60.0
Bone: elastic work2.83.65.51.7-1.72.12.3-0.72.12.22.22.2-1.9-1.9-2.11.91.6-1.3
Bone: endosteal estimation0.20.42.3-0.40.30.50.81.50.2-0.20.80.80.20.2-0.2-0.3-1.10.1
Bone: endosteal perimeter0.30.62.3-1.51.4-0.40.11.4-0.5-0.6-0.0-0.00.40.40.3-0.7-1.20.4
Epididymis fat weight2.89.621.11.9-1.71.91.6-4.33.43.32.92.9-3.2-3.2-3.63.34.6-2.9
Delta time in closed arm before/after self-admin2.42.23.60.6-0.51.91.4-0.01.61.81.41.4-1.8-1.8-1.71.61.4-1.8
Delta time in open arm before/after self-admin2.82.84.1-1.00.8-1.7-1.80.4-2.0-1.8-2.0-2.01.81.81.8-1.7-1.41.9
Diff in mean of infusions in LGA sessions0.40.51.91.4-1.41.00.80.10.50.40.50.5-0.2-0.2-0.30.40.30.3
Delay discount exponential model param2.22.54.6-1.41.50.50.8-1.82.01.22.12.1-1.5-1.5-1.01.41.9-1.7
Extinction: sum of active levers before priming0.80.91.9-0.1-0.1-0.8-0.51.0-1.0-1.0-0.8-0.81.21.20.7-1.3-1.31.4
Active lever presses in extinction session 60.30.30.90.8-0.9-0.4-0.2-0.9-0.1-0.50.10.10.70.70.3-0.6-0.20.9
Bone: final force0.30.53.4-1.81.8-0.6-0.30.50.0-0.20.20.20.00.00.2-0.2-0.0-0.2
Bone: final moment0.30.42.4-1.61.5-0.7-0.40.6-0.2-0.4-0.0-0.00.40.40.4-0.5-0.20.2
Food consumed during 24 hour testing period0.30.41.20.8-0.90.1-0.0-0.5-0.7-0.3-0.9-0.90.50.50.0-0.4-0.31.1
Glucose0.71.05.4-1.01.1-0.6-0.5-2.30.90.50.80.8-0.6-0.6-0.50.61.6-1.0
Heart weight1.32.05.32.3-2.31.61.4-0.91.21.41.11.1-1.1-1.1-1.51.31.1-0.9
Delay discount hyperbolic model param2.42.64.8-1.01.20.61.0-1.92.11.32.22.2-1.6-1.6-1.31.62.0-1.8
Intermittent access intake day 1-15 change0.10.20.90.5-0.50.20.9-0.10.60.30.80.8-0.2-0.2-0.40.2-0.1-0.2
Intermittent access intake escalation0.20.51.60.6-0.70.41.3-0.10.90.51.11.1-0.5-0.5-0.60.50.1-0.5
Intermittent access intake escalation 20.20.20.90.7-0.70.10.80.90.00.10.20.20.00.00.1-0.1-0.8-0.1
Intermitt. access day 1 inactive lever presses0.41.33.2-0.40.50.30.9-0.81.51.11.61.6-1.2-1.2-1.01.11.3-1.8
Intermitt. access day 15 inactive lever presses0.10.31.3-1.11.1-0.8-0.70.1-0.1-0.3-0.1-0.10.20.20.6-0.20.2-0.4
Intermitt. access escalation Index0.20.30.6-0.60.5-0.2-0.7-0.5-0.5-0.5-0.5-0.50.50.50.3-0.5-0.10.8
Intermittent access day 1 total infusions0.20.20.60.2-0.00.8-0.1-0.70.50.30.20.2-0.5-0.5-0.30.80.8-0.5
Intermittent access day 15 total infusions0.40.50.80.5-0.40.60.8-0.90.90.60.90.9-0.7-0.7-0.70.80.7-0.5
Intermittent access terminal intake (last 3 days)0.00.10.20.2-0.20.50.3-0.10.30.20.20.2-0.3-0.3-0.10.40.10.0
Intermittent access total infusions0.00.00.10.1-0.10.40.0-0.30.20.10.00.0-0.2-0.2-0.10.40.2-0.0
Intermittent access day 1 locomotion0.30.41.20.10.01.10.1-1.10.70.60.50.5-0.6-0.6-0.50.71.10.0
Intermittent access day 15 total locomotion0.20.41.60.4-0.31.30.6-0.00.60.60.40.4-0.6-0.6-0.80.60.5-0.2
Intermittent access total locomotion0.20.20.8-0.20.30.90.3-0.20.60.50.50.5-0.6-0.6-0.60.50.5-0.3
Intermittent access standard deviation0.10.30.80.10.00.30.70.70.50.40.50.5-0.6-0.6-0.20.6-0.1-0.9
Left kidney weight0.31.55.81.0-1.01.10.4-2.41.41.01.21.2-0.8-0.8-1.41.01.6-0.6
Right kidney weight0.20.76.90.6-0.7-0.3-0.8-2.60.5-0.00.30.30.20.2-0.50.11.10.3
Cocaine induced anxiety0.60.93.5-0.00.20.20.8-0.31.10.91.01.0-1.2-1.2-0.61.10.9-1.9
Post-drug Anxiety2.52.74.61.5-1.32.12.10.41.61.81.61.6-1.8-1.8-1.61.81.0-1.8
Baseline Anxiety0.70.83.21.4-1.41.80.91.4-0.30.1-0.2-0.20.10.1-0.4-0.1-0.91.0
Tail length1.45.58.20.8-0.61.92.0-2.12.82.52.72.7-2.5-2.5-2.92.52.8-2.3
Length with tail3.012.918.91.7-1.43.54.0-1.94.23.94.44.4-3.9-3.9-4.23.83.6-3.2
Length without tail1.96.19.11.3-1.12.62.7-1.63.02.73.03.0-2.6-2.6-2.92.62.5-2.0
Times rat made contact with spout0.60.71.3-0.50.60.40.2-1.10.70.80.30.3-1.0-1.0-1.10.91.2-1.1
Lifetime Intake0.00.00.1-0.00.10.3-0.2-0.0-0.1-0.2-0.1-0.10.10.10.20.1-0.10.3
Liver weight, left0.20.41.51.0-1.20.5-0.3-0.7-0.2-0.3-0.2-0.20.60.6-0.3-0.5-0.21.0
Liver weight, right1.22.03.01.0-0.91.31.4-1.21.71.61.71.7-1.4-1.4-1.61.41.6-1.1
Locomotor activity1.93.04.70.6-0.41.41.8-1.12.21.92.22.2-1.9-1.9-1.61.91.9-1.6
Locomotor testing distance1.42.53.8-0.10.30.81.3-1.31.91.72.02.0-1.8-1.8-1.41.82.0-1.7
Locomotor testing rearing0.20.41.9-0.90.8-0.8-0.6-1.40.2-0.40.60.60.50.50.4-0.30.40.4
Locomotion in novel chamber0.70.92.3-0.40.4-1.0-1.30.1-1.2-1.0-1.5-1.50.90.90.9-1.0-0.80.5
Locomotion in novel chamber post-restriction1.32.24.5-0.0-0.1-1.4-1.10.7-1.8-1.8-1.7-1.71.71.71.5-1.6-2.11.2
Fecal boli incidents, locomotor time 11.01.42.5-0.1-0.1-0.8-1.20.8-1.3-1.4-1.2-1.21.61.61.2-1.4-1.31.4
Change in fecal boli incidents, locomotor task0.40.42.21.5-1.50.60.6-0.10.10.2-0.1-0.1-0.1-0.1-0.40.2-0.10.1
Time >=10cm from walls, locomotor time 10.20.20.5-0.1-0.0-0.4-0.50.0-0.3-0.6-0.0-0.00.70.70.1-0.6-0.50.4
Bouts of movement, locomotor time 10.60.72.3-1.51.5-0.6-1.2-0.8-0.8-0.6-0.9-0.90.40.40.4-0.5-0.00.4
Total resting periods, locomotor time 10.70.83.5-1.91.9-0.9-1.2-0.8-0.6-0.6-0.6-0.60.40.40.4-0.50.00.3
Rest time, locomotor task time 12.42.94.7-1.81.9-2.2-2.00.9-1.8-1.8-2.1-2.11.41.42.1-1.5-1.20.8
Distance moved, locomotor task time 10.20.31.0-0.20.10.10.2-1.00.60.40.90.9-0.3-0.3-0.60.20.7-0.2
Vertical activity count, locomotor time 10.61.43.51.8-1.91.41.3-0.61.11.11.31.3-0.7-0.7-1.40.80.7-0.2
Time >=10cm from walls, locomotor time 20.40.63.11.7-1.81.20.70.10.50.40.60.6-0.0-0.0-0.50.30.10.4
Bouts of movement, locomotor time 20.20.31.3-0.60.6-1.1-0.5-1.00.1-0.0-0.0-0.0-0.2-0.2-0.10.30.5-1.0
Total resting periods, locomotor time 20.20.31.4-0.30.4-1.0-0.2-0.90.20.20.10.1-0.4-0.4-0.30.50.5-1.2
Rest time, locomotor task time 20.60.81.6-1.11.3-1.1-1.01.0-0.9-0.7-1.2-1.20.40.40.8-0.5-0.6-0.4
Distance moved, locomotor task time 20.20.31.2-1.11.0-0.3-0.3-0.3-0.2-0.40.10.10.40.40.6-0.5-0.20.7
Vertical activity count, locomotor time 20.20.20.70.7-0.80.30.70.90.10.00.40.40.20.20.1-0.1-0.60.4
Light reinforcement 10.00.10.4-0.40.3-0.0-0.3-0.60.0-0.20.20.20.20.2-0.2-0.20.10.4
Light reinforcement 20.50.72.8-1.61.70.30.2-0.90.70.50.80.8-0.8-0.8-0.60.50.8-0.7
Bone: marrow area0.20.42.5-0.40.30.60.81.60.2-0.10.80.80.10.1-0.2-0.3-1.10.1
Bone: maximum diameter1.32.53.6-1.91.8-1.4-1.11.7-1.7-1.6-1.5-1.51.41.41.4-1.7-1.71.4
Bone: maximum force0.30.61.7-1.01.00.40.70.30.90.61.31.3-0.6-0.6-0.60.50.4-0.7
Bone: maximum moment0.20.31.3-0.60.50.30.60.30.70.41.11.1-0.3-0.3-0.60.20.2-0.3
Mean time between licks in bursts0.10.31.20.3-0.31.10.80.9-0.20.4-0.3-0.3-0.4-0.4-0.30.1-0.5-0.1
Mean num. licks in bursts0.30.50.90.4-0.5-0.5-0.80.5-0.6-0.8-0.5-0.50.90.90.6-0.8-0.80.8
Cd content in liver0.30.31.00.8-0.80.60.30.6-0.0-0.30.10.10.40.40.2-0.4-0.71.0
Co content in liver1.11.33.81.9-1.91.71.2-0.90.81.20.50.5-0.9-0.9-1.01.00.9-0.4
Cu content in liver0.81.01.7-0.2-0.0-0.9-0.80.7-1.0-1.2-0.8-0.81.31.30.9-1.3-1.31.1
Fe content in liver0.20.31.1-0.50.5-1.1-0.9-0.2-0.3-0.3-0.5-0.50.40.40.5-0.40.0-0.2
K content in liver3.12.94.50.4-0.21.92.10.31.91.92.12.1-2.0-2.0-1.91.81.2-1.9
Mg content in liver0.50.50.80.4-0.30.90.5-0.10.80.70.70.7-0.8-0.8-0.60.80.7-0.9
Mn content in liver0.20.20.80.3-0.20.90.5-0.10.30.40.10.1-0.6-0.6-0.40.60.2-0.6
Na content in liver0.30.41.40.0-0.00.00.2-1.20.70.50.70.7-0.5-0.5-0.80.50.9-0.7
Rb content in liver0.60.73.11.2-1.31.10.91.80.10.00.50.50.20.20.1-0.3-1.20.5
Se content in liver1.21.42.3-0.90.8-1.5-1.5-0.2-1.4-1.2-1.5-1.51.21.21.1-1.2-0.71.3
Sr content in liver0.10.10.30.2-0.3-0.50.4-0.20.20.10.50.50.00.0-0.00.10.20.2
Zn content in liver0.80.91.7-0.30.1-0.9-1.10.5-0.8-1.2-0.5-0.51.31.31.2-1.2-1.11.2
Bone: minimum diameter0.30.62.7-1.21.1-0.20.21.6-0.6-0.5-0.4-0.40.40.40.5-0.8-1.10.6
Time in familiar zone, hab. session 10.80.84.61.6-1.60.5-0.3-2.20.30.20.10.10.10.1-0.60.00.80.6
Time in novel zone, hab. session 10.50.53.0-0.90.9-0.60.01.7-0.3-0.5-0.0-0.00.50.50.8-0.5-1.00.0
Total zone transitions, hab. session 10.81.25.2-2.32.3-1.5-1.5-0.8-0.2-0.7-0.1-0.10.50.50.8-0.60.3-0.3
Total locomotion distance, hab. session 10.81.13.4-1.81.8-1.4-1.7-1.2-0.4-1.0-0.3-0.30.90.90.7-0.80.10.2
Locomotion velocity, hab. session 10.81.13.7-1.91.9-1.3-1.6-1.0-0.5-1.0-0.4-0.40.80.80.8-0.80.00.2
Time in familiar zone, hab. session 22.83.05.92.3-2.22.42.1-0.91.51.81.31.3-1.7-1.7-1.91.71.3-0.8
Time in novel zone, hab. session 22.72.85.2-1.91.7-2.3-2.10.4-1.5-1.8-1.3-1.31.91.91.8-1.8-1.11.1
Total zone transitions, hab. session 20.81.14.9-2.02.2-0.6-0.0-0.60.50.50.40.4-0.9-0.9-0.30.60.8-1.6
Total locomotion distance, hab. session 20.40.62.3-1.41.5-0.6-0.3-1.10.30.20.20.2-0.5-0.5-0.40.40.8-1.1
Locomotion velocity, hab. session 20.40.51.6-1.11.3-0.4-0.0-0.70.40.40.20.2-0.7-0.7-0.40.60.7-1.2
Novel to familiar place preference ratio0.10.10.20.3-0.30.30.30.30.20.30.10.1-0.3-0.3-0.20.40.4-0.2
Novelty place preference0.20.20.40.7-0.60.60.50.20.50.50.40.4-0.4-0.4-0.40.50.5-0.2
Time in novel zone, NPP test0.10.10.40.6-0.60.50.20.10.30.30.20.2-0.2-0.2-0.30.30.40.0
Total zone transitions, NPP test1.11.69.0-2.83.0-1.7-1.3-0.60.1-0.30.10.1-0.2-0.20.40.00.6-1.3
Total locomotion distance, NPP test1.31.79.7-2.93.1-1.7-1.4-0.4-0.0-0.4-0.1-0.1-0.1-0.10.50.00.6-1.3
Locomotion velocity, NPP test1.21.78.9-2.83.0-1.1-0.7-0.30.60.10.60.6-0.7-0.7-0.00.60.9-1.8
Intraocular pressure0.30.42.71.5-1.60.70.5-0.30.20.00.20.20.30.3-0.0-0.1-0.10.9
Delta distance traveled before/after self-admin0.70.74.2-2.02.1-0.9-0.7-0.4-0.4-0.7-0.4-0.40.20.20.3-0.5-0.2-0.1
Delta ambulatory time before/after self-admin0.30.42.3-1.41.5-0.8-0.1-0.2-0.1-0.4-0.1-0.1-0.1-0.10.2-0.2-0.2-0.4
Parametrial fat weight1.53.415.3-0.10.20.70.1-3.92.21.52.02.0-1.5-1.5-1.91.63.0-1.3
Pavlov. Cond. lever latency0.30.31.70.7-0.71.31.00.30.30.50.20.2-0.5-0.5-0.60.40.10.3
Pavlov. Cond. magazine entry latency1.31.74.8-0.80.7-2.2-1.50.0-1.2-1.6-0.8-0.81.61.61.5-1.4-1.30.8
Pavlov. Cond. change in total contacts0.80.82.1-0.80.7-1.5-1.4-0.2-0.6-1.2-0.4-0.41.11.11.1-0.9-0.60.4
Pavlov. Cond. index score1.01.35.2-1.21.2-2.3-1.6-0.5-0.7-1.3-0.4-0.41.11.11.3-0.9-0.6-0.0
Pavlov. Cond. latency score1.01.24.4-1.11.0-2.1-1.6-0.1-0.7-1.4-0.4-0.41.21.21.4-1.0-0.80.2
Pavlov. Cond. lever contacts0.20.31.8-0.50.5-1.3-1.0-0.7-0.1-0.4-0.0-0.00.40.40.3-0.30.2-0.4
Pavlov. Cond. magazine entry number1.31.76.11.3-1.32.51.80.70.91.50.60.6-1.4-1.4-1.41.10.8-0.3
Pavlov. Cond. intertrial magazine entries0.30.31.41.0-1.11.20.50.2-0.10.4-0.2-0.2-0.1-0.1-0.50.00.10.5
Pavlov. Cond. lever-magazine prob. diff.1.01.24.9-1.11.0-2.2-1.6-0.5-0.7-1.3-0.3-0.31.21.21.3-1.0-0.60.1
Pavlov. Cond. response bias0.60.73.7-0.80.8-1.9-1.3-1.0-0.5-0.9-0.3-0.30.70.70.7-0.5-0.1-0.1
Pavlov. Cond. lever latency1.11.68.62.8-2.91.50.70.3-0.40.1-0.6-0.60.30.3-0.3-0.3-0.41.7
Pavlov. Cond. magazine entry latency0.91.16.7-2.52.6-1.2-0.9-0.40.1-0.20.00.0-0.1-0.10.3-0.10.5-0.9
Pavlov. Cond. change in total contacts1.01.66.7-2.42.6-1.2-0.5-0.90.80.30.90.9-0.7-0.7-0.20.60.9-2.1
Pavlov. Cond. index score1.41.910.5-3.13.2-1.8-1.1-0.80.3-0.20.40.4-0.3-0.30.40.10.7-1.6
Pavlov. Cond. latency score1.41.910.3-3.13.2-1.8-1.1-0.80.3-0.10.40.4-0.3-0.30.40.10.7-1.6
Pavlov. Cond. lever contacts1.11.68.1-2.72.8-1.4-0.5-0.50.50.10.60.6-0.5-0.50.10.50.6-1.8
Pavlov. Cond. magazine entry number0.70.85.22.2-2.31.00.8-0.0-0.10.2-0.1-0.10.00.0-0.40.1-0.20.8
Pavlov. Cond. intertrial magazine entries0.60.93.41.8-1.81.31.0-0.30.70.60.80.8-0.5-0.5-0.70.70.30.0
Pavlov. Cond. lever-magazine prob. diff.1.31.78.9-2.83.0-1.5-0.9-0.90.50.10.50.5-0.5-0.50.10.30.9-1.7
Pavlov. Cond. response bias1.01.37.9-2.72.8-1.1-0.50.10.30.00.40.4-0.4-0.40.20.20.3-1.5
Time in closed arm before self-admin0.30.41.1-0.60.8-0.30.1-0.50.70.30.60.6-0.6-0.60.00.70.7-1.1
Time in closed arm after self-admin2.22.45.8-0.81.10.50.5-1.61.91.41.61.6-1.7-1.7-1.11.62.1-2.4
Time in open arm before self-admin0.30.41.41.1-1.20.50.4-0.70.50.50.60.6-0.2-0.2-0.60.30.40.0
Time in open arm after self-admin1.11.23.40.3-0.6-0.6-0.90.3-1.4-1.0-1.2-1.21.41.40.7-1.2-1.11.9
Bone: periosteal estimation0.51.12.9-1.51.3-0.5-0.21.7-0.9-1.0-0.4-0.40.90.90.7-1.2-1.51.0
Bone: periosteal perimeter0.20.42.5-1.61.5-0.20.20.60.1-0.20.50.5-0.0-0.0-0.1-0.3-0.30.0
Bone: post-yield work0.81.23.3-0.00.00.91.1-0.31.51.11.81.8-1.0-1.0-1.11.10.9-1.1
Progressive ratio test 1 active lever presses0.91.11.80.3-0.21.10.7-1.11.31.01.41.4-1.1-1.1-0.81.31.4-0.9
Progressive ratio test 1 breakpoint1.01.21.90.5-0.41.20.9-1.11.41.11.41.4-1.1-1.1-0.81.31.3-0.8
Progressive ratio test 1 inactive lever presses0.30.51.30.6-0.60.70.2-1.20.90.40.90.9-0.3-0.3-0.40.50.8-0.3
Progressive ratio test 2 active lever presses0.70.84.00.4-0.40.30.3-2.01.20.51.11.1-0.5-0.5-0.40.81.2-0.5
Progressive ratio test 2 breakpoint0.91.04.60.6-0.60.50.4-2.11.30.71.31.3-0.6-0.6-0.60.91.4-0.6
Progressive ratio test 2 inactive lever presses0.20.31.1-0.80.8-0.3-0.8-1.10.1-0.40.00.00.20.20.5-0.10.3-0.1
Incentive Sensitization - Responses0.50.75.60.3-0.4-0.4-0.3-2.40.90.20.80.8-0.1-0.1-0.30.41.2-0.6
Incentive Sensitization - Breakpoint0.40.54.90.2-0.2-0.5-0.4-2.20.70.10.60.6-0.0-0.0-0.20.31.1-0.5
Sum of active levers in priming session hrs 5-64.64.37.50.0-0.3-1.3-1.31.9-2.7-2.2-2.5-2.52.32.31.3-2.3-2.72.6
Progressive ratio0.50.82.11.2-1.30.71.50.70.70.81.11.1-0.4-0.4-1.00.4-0.2-0.4
Food seeking constrained by brief footshock0.70.92.8-0.00.11.71.40.21.10.81.31.3-0.9-0.9-0.80.70.4-0.2
Seeking ratio, punishment vs. effort0.30.51.7-1.21.3-0.1-0.7-0.2-0.4-0.7-0.6-0.60.40.40.9-0.5-0.20.8
Retroperitoneal fat weight0.41.916.40.7-0.8-0.2-0.9-4.01.10.50.90.9-0.2-0.2-1.10.52.3-0.1
Reaction time number correct3.36.39.2-2.32.0-2.9-3.00.8-2.6-2.9-2.5-2.52.82.82.6-2.8-2.12.1
Reaction time mean minus median0.40.91.51.0-0.91.21.20.51.11.01.11.1-0.9-0.9-0.61.00.5-1.0
Reaction time mean minus median AUC0.30.81.50.5-0.40.91.20.81.10.91.21.2-0.9-0.9-0.40.90.3-1.2
Reaction time num false alarms0.20.30.8-0.30.3-0.3-0.70.2-0.6-0.5-0.9-0.90.40.40.8-0.5-0.50.2
Reaction time num false alarms AUC0.10.20.7-0.00.0-0.2-0.70.2-0.6-0.4-0.8-0.80.40.40.7-0.4-0.40.2
Reaction time trials correct on left3.36.39.2-2.32.0-2.9-3.00.8-2.6-2.9-2.5-2.52.82.82.6-2.8-2.12.1
Reaction time trials on left3.36.19.1-2.32.0-2.9-3.00.7-2.5-2.8-2.5-2.52.72.72.6-2.8-2.12.0
Reaction time mean3.65.78.01.5-1.32.42.5-0.92.82.72.72.7-2.6-2.6-2.42.82.2-2.8
Reaction time mean AUC2.94.77.50.8-0.52.02.2-0.72.62.42.52.5-2.5-2.5-2.02.62.1-2.7
Median of all reaction times4.25.98.31.4-1.12.32.4-1.22.82.72.72.7-2.7-2.7-2.52.82.4-2.9
Reaction time omissions0.81.22.80.7-0.40.70.7-1.41.11.10.70.7-1.3-1.3-0.81.41.4-1.7
Reaction time false alarm rate0.50.61.40.9-0.81.20.8-0.10.71.00.50.5-1.0-1.0-0.60.80.6-0.8
Reaction time premature initiation rate0.00.00.10.0-0.1-0.10.0-0.00.00.30.20.2-0.1-0.10.00.10.2-0.0
Reaction time premature initiations0.61.01.8-0.80.6-1.3-1.30.2-1.0-1.0-0.8-0.81.21.21.2-1.2-0.70.9
Std. dev. reaction times2.13.96.51.2-1.01.92.1-0.32.32.22.22.2-2.2-2.2-1.62.31.8-2.5
Reaction time trials completed3.36.19.1-2.32.0-2.9-3.00.7-2.5-2.8-2.5-2.52.72.72.6-2.8-2.12.0
Reaction time trials AUC3.16.09.2-2.42.1-2.9-3.00.5-2.5-2.8-2.4-2.42.72.72.5-2.8-2.02.0
Run reversals in cocaine runway, females0.20.20.7-0.60.6-0.60.20.80.2-0.30.50.50.30.30.5-0.2-0.50.1
Run reversals in cocaine runway, males0.20.20.50.1-0.3-0.2-0.5-0.7-0.1-0.4-0.1-0.10.60.60.3-0.5-0.10.5
Latency to leave start box in cocaine runway1.21.44.70.8-1.00.71.2-1.11.60.92.22.2-0.5-0.5-1.00.61.0-0.3
Latency to leave start box in cocaine runway, F0.30.31.3-0.80.7-0.20.1-0.50.60.01.21.20.10.1-0.3-0.10.3-0.1
Latency to leave start box in cocaine runway, M2.22.13.81.9-2.01.21.4-1.41.81.21.91.9-0.9-0.9-1.21.11.4-0.4
Std. dev. time between licks in bursts0.40.61.50.3-0.40.30.01.2-0.7-0.6-0.6-0.60.80.80.6-0.9-1.21.1
Total sessions with >9 infusions0.40.51.1-0.40.2-0.2-0.60.7-0.5-0.8-0.3-0.30.90.91.0-0.7-0.81.0
Short access day 1 total inactive lever presses0.00.00.1-0.0-0.00.3-0.3-0.20.1-0.00.20.20.10.10.3-0.00.30.4
Short access day 10 total inactive lever presses0.20.62.9-0.80.8-1.7-1.10.3-0.6-0.5-0.7-0.70.60.60.8-0.6-0.0-0.6
Short access day 1 total infusions0.40.51.4-0.50.3-0.5-1.2-0.1-0.6-0.9-0.5-0.51.01.01.0-0.8-0.40.8
Short access day 10 total infusions0.00.00.3-0.20.30.20.10.5-0.10.1-0.1-0.1-0.2-0.20.10.3-0.1-0.1
Short access total infusions0.40.51.0-0.50.4-0.1-0.70.7-0.8-0.8-0.7-0.70.80.80.9-0.6-0.81.0
Short access day 1 locomotion0.40.41.1-0.80.7-0.3-0.61.1-0.5-0.6-0.2-0.20.80.80.7-0.8-0.70.8
Short access day 10 total locomotion0.10.10.3-0.40.50.30.10.20.20.30.00.0-0.5-0.5-0.30.40.3-0.5
Short access total locomotion0.30.41.5-0.20.00.2-0.31.0-0.6-0.5-0.5-0.50.70.70.6-0.6-0.71.2
One hour access (0.3 mA shock)0.40.51.10.1-0.2-0.6-0.9-0.6-0.5-0.9-0.4-0.41.01.00.7-0.6-0.51.0
Compulsive drug intake0.91.12.0-0.70.5-1.4-1.30.6-1.1-1.2-0.9-0.91.31.30.9-1.3-1.10.5
One hour access (shock baseline)0.20.31.7-0.00.10.40.3-1.30.60.30.50.5-0.5-0.5-0.30.60.70.1
Social response proportion0.30.41.10.4-0.21.10.60.80.30.60.20.2-0.7-0.7-0.50.70.2-0.7
Social responses0.60.81.51.1-1.01.21.10.90.70.90.70.7-0.8-0.8-0.90.80.2-0.9
Social time2.43.25.0-0.40.2-1.9-2.20.3-2.1-2.0-2.0-2.02.22.21.7-1.9-1.62.0
Soleus weight0.10.31.7-1.31.3-0.5-0.5-0.80.0-0.30.30.30.20.20.3-0.30.20.2
Bone: stiffness0.20.31.1-1.01.0-0.3-0.30.20.5-0.20.80.80.10.10.0-0.1-0.0-0.3
Tibialis anterior weight0.41.33.9-2.02.0-1.5-1.6-1.3-0.7-0.9-0.8-0.80.70.70.9-0.60.20.1
Time to tail flick, vehicle, before self-admin0.10.10.5-0.30.3-0.7-0.10.6-0.1-0.30.10.10.20.20.7-0.2-0.40.1
Time to tail flick, vehicle, after self-admin0.60.84.2-0.40.7-0.00.81.30.60.80.40.4-1.2-1.20.11.10.2-2.0
Time to tail flick, test, before self-admin8.89.112.4-2.11.9-2.8-2.92.0-3.5-3.3-3.5-3.53.23.23.4-3.2-3.33.0
Time to tail flick, test, after self-admin2.02.05.0-1.81.8-2.2-1.60.3-1.4-1.4-1.4-1.41.11.12.1-1.0-0.90.4
Delta time to tail flick, vehicle, before/after SA0.40.31.1-0.91.1-0.5-0.40.8-0.5-0.2-0.6-0.6-0.1-0.10.6-0.0-0.3-0.7
Delta time to tail flick, test, before/after SA4.14.210.6-0.10.40.71.3-1.82.32.12.12.1-2.4-2.4-1.72.52.7-3.3
Tibia length1.44.010.4-3.23.1-2.5-2.7-0.2-1.7-2.0-1.8-1.81.61.61.9-1.7-0.80.9
Ambulatory time before self-admin0.50.83.21.7-1.80.8-0.2-1.80.30.30.20.20.20.2-0.20.20.90.9
Ambulatory time after self-admin0.40.52.9-0.60.5-0.8-0.8-1.7-0.2-0.6-0.3-0.30.50.50.6-0.50.40.5
Bone: tissue strength0.10.10.50.6-0.70.20.0-0.50.20.30.10.1-0.0-0.0-0.30.20.40.1
Total heroin consumption0.10.20.60.4-0.4-0.10.6-0.10.60.20.80.8-0.2-0.2-0.30.10.1-0.3
Bone: trabecular number0.20.41.8-1.11.30.00.40.70.20.20.20.2-0.7-0.70.10.3-0.1-1.1
Bone: trabecular spacing0.30.51.81.2-1.3-0.3-0.7-0.7-0.4-0.3-0.6-0.60.70.70.1-0.40.00.8
Bone: trabecular thickness0.60.83.7-1.61.7-0.00.51.90.1-0.20.50.5-0.3-0.30.6-0.0-1.0-0.6
Bone: trabecular tissue density6.810.115.4-2.11.8-3.7-3.90.6-3.4-3.7-3.3-3.33.73.73.5-3.4-2.63.0
Water consumed over 24 hours0.20.32.0-0.20.2-0.2-0.7-1.4-0.2-0.1-0.6-0.60.10.1-0.3-0.10.60.2
Number of responses in last shaping day0.30.41.7-0.60.5-1.1-0.6-1.30.2-0.50.30.30.50.50.5-0.50.10.3