Hub : Genes

Vasp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	XM_039081742.2	0.01	0.02	9.1e-03	0.01	0.01	0.01	0.01	1.6e-02	2.1e-02	3.9e-02	3.0e-02
2	Liver	alternative TSS	XM_039081742.2	0.18	0.14	2.5e-09	0.07	0.07	0.07	0.07	1.9e-08	2.4e-08	2.8e-08	1.6e-08
3	Liver	isoform ratio	XM_039081742.2	0.02	0.02	4.5e-03	0.02	0.02	0.01	0.02	4.7e-03	4.7e-03	2.3e-02	6.6e-03
4	NAcc	isoform ratio	NM_001108475.2	0.02	0.02	2.7e-03	0.01	0.01	0	0	2.1e-02	4.1e-02	3.0e-01	7.8e-02
5	OFC	alternative TSS	XM_039081742.2	0.16	0.16	5.9e-03	0.09	0.08	0.07	0.08	4.5e-03	5.3e-03	8.0e-03	6.6e-03
6	Liver	alternative TSS	NM_001108475.2	0.03	0.03	7.7e-04	0.02	0.02	0.04	0.02	1.3e-03	4.0e-03	3.9e-05	2.5e-03
7	Adipose	isoform ratio	XR_010054317.1	0.03	0.04	1.6e-03	0.03	0.02	0.02	0.03	6.1e-04	1.1e-03	5.1e-03	6.9e-04
8	Adipose	mRNA stability	Vasp	0.07	0.06	1.9e-08	0.07	0.07	0.07	0.07	6.9e-08	8.3e-08	5.3e-08	8.4e-08
9	Liver	isoform ratio	NM_001108475.2	0.04	0.07	4.4e-03	0.02	0.01	0.03	0.02	1.6e-03	1.9e-02	3.4e-04	1.9e-03
10	Adipose	gene expression	Vasp	0.44	0.18	4.1e-05	0.02	0.04	0.04	0.02	1.1e-03	2.5e-05	1.6e-05	1.9e-03
11	PL	alternative TSS	XM_039081742.2	0.02	0.02	7.7e-03	0.02	0.02	0.02	0.01	3.2e-03	6.4e-03	1.5e-03	7.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.1	0.2	1.1	-0.2	0.2	0.0	0.3	0.0	-0.1	-0.1	0.2	-0.1	-1.1	0.5
Area under the delay curve	1.9	2.2	5.2	1.2	1.4	1.4	-1.6	1.4	-1.4	-1.4	-1.6	-1.3	-0.7	2.3
BMI with tail	0.5	1.9	2.6	-1.3	-1.4	-1.4	1.3	-1.3	1.3	1.4	1.6	1.4	0.9	-1.6
BMI without tail	0.6	1.9	2.2	-1.4	-1.4	-1.4	1.3	-1.4	1.4	1.5	1.4	1.5	1.3	-1.1
Body weight	1.0	4.5	5.2	-2.1	-2.2	-2.2	2.2	-2.1	2.1	2.2	2.3	2.2	1.6	-2.0
Weight adjusted by age	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.1	-0.1	0.0	0.1	-0.0	0.0	0.0	-0.3
Bone surface	0.2	0.4	0.8	-0.7	-0.5	-0.6	0.9	-0.5	0.5	0.5	0.9	0.5	-0.1	-0.6
Bone volume	0.2	0.3	0.7	-0.6	-0.4	-0.5	0.8	-0.5	0.4	0.4	0.8	0.4	-0.5	-0.3
Breakpoint value in progressive ratio session	2.1	2.5	2.9	1.7	1.6	1.6	-1.7	1.6	-1.6	-1.6	-1.6	-1.6	-1.4	1.4
Number of licking bursts	2.3	3.8	7.1	-1.8	-2.1	-1.9	1.4	-2.1	2.1	2.1	1.5	2.1	2.7	-0.9
Context. condit. distance diff. score	0.1	0.2	0.4	-0.2	-0.3	-0.4	0.4	-0.4	0.5	0.4	0.4	0.5	-0.1	-0.6
Locomotion velocity, session 1	0.1	0.1	0.3	0.3	0.3	0.2	-0.3	0.1	-0.1	-0.1	-0.3	-0.1	-0.3	0.5
Locomotion distance, session 1	0.0	0.1	0.2	-0.4	-0.1	-0.2	0.4	0.0	-0.0	-0.0	0.3	-0.0	0.2	-0.2
Locomotion velocity, session 2	1.3	1.5	1.8	-1.1	-1.2	-1.2	1.0	-1.4	1.4	1.4	1.0	1.4	1.3	-1.0
Locomotion distance, session 2	0.3	0.4	0.8	-0.7	-0.5	-0.6	0.8	-0.4	0.4	0.4	0.8	0.4	0.3	-0.9
Locomotion velocity, session 3	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.5	-0.5	0.5	0.5	0.5	0.5	0.4	-0.5
Locomotion distance, session 3	0.7	0.8	1.1	1.1	0.9	0.9	-0.8	1.0	-1.0	-1.0	-0.9	-1.0	-0.8	0.3
Stereotopy head waving bouts, day 3	1.0	1.1	2.1	-0.8	-1.1	-1.0	0.8	-1.2	1.2	1.2	0.7	1.2	1.4	-0.6
Stereotopy head waving duration, day 3	1.1	1.3	1.5	-1.1	-1.2	-1.1	1.0	-1.2	1.2	1.2	1.0	1.2	1.2	-0.9
Locomotion velocity, session 7	0.3	0.3	0.9	0.5	0.4	0.4	-0.1	0.5	-0.5	-0.5	-0.1	-0.5	-0.9	-0.8
Locomotion distance, session 7	0.2	0.2	2.1	0.0	-0.2	-0.1	0.3	0.1	-0.0	-0.1	0.3	-0.0	0.1	-1.4
Stereotopy head waving bouts, day 7	1.0	1.1	1.8	-1.0	-1.0	-1.1	0.9	-1.3	1.3	1.3	1.0	1.3	0.5	-0.1
Stereotopy head waving duration, day 7	0.8	0.9	1.5	-0.9	-0.9	-1.0	0.8	-1.2	1.2	1.2	0.8	1.2	0.7	-0.0
Locomotion velocity, session 8	0.0	0.0	0.1	0.2	0.0	0.0	-0.1	0.0	-0.0	-0.0	-0.1	-0.0	0.1	-0.3
Locomotion distance, session 8	0.1	0.1	0.7	-0.0	0.0	-0.1	0.4	-0.0	0.0	0.0	0.4	0.1	-0.9	-0.8
Degree of sensitization distance	0.6	0.6	1.5	-0.7	-0.8	-0.8	0.8	-0.6	0.7	0.6	0.8	0.7	0.8	-1.2
Degree of sensitization stereotypy	1.0	1.1	1.7	-1.1	-1.0	-1.1	1.0	-1.3	1.2	1.3	1.0	1.2	0.5	-0.2
Conditioned locomotion	0.0	0.1	0.1	0.2	0.2	0.2	-0.2	0.3	-0.3	-0.3	-0.1	-0.3	-0.1	0.2
Cocaine response after cond. corrected	0.6	0.7	1.1	-0.7	-0.8	-0.8	0.8	-0.8	0.8	0.8	1.0	0.8	0.3	-1.1
Cocaine response after cond. not corrected	1.4	1.7	2.9	-1.2	-1.3	-1.3	1.3	-1.3	1.3	1.3	1.5	1.3	0.5	-1.7
Cocaine response before conditioning	1.5	1.8	1.9	-1.4	-1.4	-1.4	1.3	-1.3	1.3	1.4	1.3	1.4	1.3	-1.4
Saline control response	2.0	2.6	3.2	-1.7	-1.7	-1.7	1.8	-1.7	1.7	1.7	1.6	1.7	1.6	-0.9
Bone: connectivity density	0.1	0.2	1.4	0.0	0.4	0.2	0.1	0.3	-0.3	-0.3	0.1	-0.3	-1.2	0.3
Bone: cortical apparent density	0.1	0.1	0.6	0.5	0.4	0.3	-0.1	0.2	-0.2	-0.1	-0.2	-0.2	-0.7	0.0
Bone: cortical area	1.5	2.3	2.7	-1.6	-1.6	-1.6	1.6	-1.5	1.5	1.5	1.5	1.5	1.6	-1.0
Bone: cortical porosity	0.2	0.2	0.5	0.6	0.3	0.4	-0.6	0.3	-0.3	-0.3	-0.7	-0.3	0.4	0.4
Bone: cortical porosity	0.0	0.0	0.2	0.2	-0.1	0.0	-0.2	-0.1	0.1	0.1	-0.3	0.1	0.5	0.2
Bone: cortical thickness	0.6	0.9	1.1	-1.0	-1.0	-1.0	1.1	-1.0	0.9	1.0	1.0	0.9	0.9	-0.7
Bone: cortical thickness	1.4	1.6	2.0	-1.4	-1.2	-1.3	1.4	-1.4	1.3	1.4	1.3	1.3	0.7	-1.0
Bone: cortical tissue density	0.1	0.2	0.7	0.6	0.6	0.4	-0.2	0.3	-0.3	-0.3	-0.3	-0.3	-0.9	0.1
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	-0.6	-0.6	-0.7	0.7	-0.7	0.7	0.8	0.9	0.8	-0.3	-0.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	-0.5	-0.4	-0.5	0.7	-0.6	0.6	0.7	0.8	0.6	-0.8	-0.2
Condit. Reinf. active responses	0.3	0.3	0.7	-0.6	-0.4	-0.5	0.6	-0.5	0.5	0.6	0.8	0.6	-0.5	-0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.1	0.2	0.2	0.1	0.4	-0.4	-0.4	0.1	-0.4	-0.5	-0.5
Incentive salience index mean	0.2	0.3	0.5	-0.4	-0.4	-0.5	0.5	-0.6	0.6	0.6	0.7	0.6	-0.3	-0.5
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.1	-0.2	0.2	0.2	0.2	0.2	-0.3	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.3	-0.2	0.3	0.3	0.4	0.3	0.3	-0.0
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.8	-0.7	-0.7	-0.7	0.8	-0.6	0.7	0.6	0.9	0.7	0.1	-0.7
Condit. Reinf. active responses	0.1	0.1	0.7	0.2	0.2	0.3	-0.4	0.4	-0.3	-0.3	-0.3	-0.2	0.1	0.8
Condit. Reinf. inactive responses	0.7	0.8	1.2	0.9	0.9	1.0	-1.0	1.0	-1.0	-0.9	-1.0	-0.9	-0.4	1.1
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.6	-0.5	-0.4	0.4	-0.3	0.3	0.4	0.5	0.4	0.6	0.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.5	0.3	0.3	0.3	-0.4	0.4	-0.4	-0.3	-0.3	-0.3	0.1	0.7
Conditioned reinforcement - actives	1.2	2.0	2.3	-1.5	-1.4	-1.5	1.5	-1.4	1.4	1.4	1.5	1.4	1.0	-1.4
Conditioned reinforcement - inactives	0.4	0.5	0.7	-0.7	-0.8	-0.8	0.7	-0.8	0.8	0.8	0.7	0.8	0.7	-0.4
Conditioned locomotion	2.1	2.8	3.2	-1.8	-1.7	-1.7	1.7	-1.7	1.7	1.7	1.7	1.7	1.2	-1.5
Patch foraging indifference point 0 sec	0.4	0.7	1.0	-1.0	-0.9	-0.9	0.7	-1.0	0.9	1.0	0.8	0.9	0.9	-0.2
Patch foraging indifference point AUC	3.0	4.4	6.5	-2.1	-2.2	-2.1	2.0	-2.1	2.1	2.0	1.9	2.1	2.5	-2.0
Delay disc. indifference point, 0s delay	1.3	1.5	2.8	1.0	1.2	1.2	-1.3	1.2	-1.2	-1.2	-1.3	-1.2	-0.7	1.7
Delay disc. indifference point, 16s delay	1.3	1.4	2.6	1.1	1.2	1.1	-1.2	1.1	-1.1	-1.1	-1.2	-1.0	-1.0	1.6
Delay disc. indifference point, 2s delay	3.9	4.3	9.6	1.8	2.0	2.0	-2.4	1.9	-1.9	-1.9	-2.4	-1.8	-0.9	3.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	-0.0	-0.2	0.3	-0.2	0.1	0.2	0.3	0.1	-0.5	-0.3
Delay disc. indifference point, 4s delay	0.0	0.0	0.3	-0.2	0.1	0.0	-0.2	0.0	-0.0	-0.0	-0.2	-0.0	0.3	0.6
Delay disc. indifference point, 8s delay	1.7	2.0	3.8	1.3	1.3	1.4	-1.6	1.4	-1.4	-1.4	-1.6	-1.4	-0.4	2.0
Indifference point function ln k	0.9	1.5	4.0	1.1	1.4	1.2	-1.0	1.1	-1.2	-1.2	-1.0	-1.2	-2.0	1.0
Indifference point function log k	0.9	1.5	4.0	1.1	1.4	1.2	-1.0	1.1	-1.2	-1.2	-1.0	-1.2	-2.0	1.0
Patch foraging total patch changes 0 sec	0.6	1.1	1.7	-1.3	-1.0	-1.1	1.1	-1.2	1.1	1.1	1.1	1.1	0.8	-0.4
Patch foraging total patch changes 12 sec	1.3	1.7	3.5	-1.3	-1.5	-1.3	1.1	-1.3	1.3	1.4	1.2	1.3	1.9	-0.7
Patch foraging total patch changes 18 sec	1.8	2.7	3.9	-2.0	-1.7	-1.7	1.7	-1.7	1.6	1.6	1.7	1.6	1.6	-1.0
Patch foraging total patch changes 24 sec	0.3	0.4	0.7	-0.8	-0.6	-0.7	0.8	-0.7	0.7	0.7	0.7	0.6	0.4	-0.5
Patch foraging total patch changes 6 sec	2.4	3.6	4.7	-2.2	-1.9	-1.9	1.9	-1.9	1.9	1.9	1.9	1.9	2.2	-1.0
Patch foraging time to switch 0 sec	2.6	5.3	7.9	2.5	2.3	2.3	-2.4	2.2	-2.2	-2.2	-2.5	-2.2	-1.5	2.8
Patch foraging water rate 0 sec	2.9	6.0	7.7	-2.6	-2.4	-2.5	2.6	-2.4	2.4	2.4	2.6	2.4	1.9	-2.8
Patch foraging water rate 12 sec	0.1	0.3	0.6	-0.6	-0.4	-0.5	0.7	-0.4	0.4	0.4	0.7	0.4	-0.1	-0.8
Patch foraging water rate 18 sec	0.2	0.2	1.0	-0.5	-0.3	-0.4	0.6	-0.3	0.3	0.2	0.5	0.3	-0.1	-1.0
Patch foraging water rate 24 sec	0.5	0.8	1.1	-1.0	-0.8	-0.9	1.0	-0.8	0.8	0.7	1.0	0.8	0.5	-1.1
Patch foraging water rate 6 sec	0.7	1.1	2.6	-1.1	-0.9	-1.0	1.3	-0.9	0.9	0.9	1.2	0.9	0.3	-1.6
Seeking ratio, delayed vs. immediate footshock	1.7	2.1	2.6	1.6	1.6	1.5	-1.4	1.4	-1.5	-1.4	-1.4	-1.5	-1.6	0.9
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.3	-0.3	0.3	0.3	0.3	0.3	0.4	0.4
Distance traveled after self-admin	0.2	0.2	0.5	0.4	0.4	0.4	-0.4	0.5	-0.5	-0.5	-0.4	-0.5	-0.0	0.7
Extensor digitorum longus weight	1.6	6.2	7.9	-2.6	-2.6	-2.7	2.8	-2.7	2.7	2.6	2.6	2.6	1.5	-1.9
Bone: elastic displacement	1.1	1.2	3.9	1.2	1.2	1.1	-1.0	0.8	-0.9	-0.9	-1.0	-0.9	-2.0	0.7
Bone: elastic work	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.2	0.2	0.2	0.2	0.1	-0.3	-0.2
Bone: endosteal estimation	0.0	0.1	0.1	0.3	0.2	0.2	-0.1	0.3	-0.3	-0.3	-0.1	-0.3	-0.4	-0.3
Bone: endosteal perimeter	0.0	0.0	0.1	0.0	-0.1	0.0	-0.1	0.1	-0.1	0.0	-0.0	-0.0	0.4	-0.0
Epididymis fat weight	0.2	0.7	1.1	1.1	0.9	0.9	-1.0	0.9	-0.9	-0.8	-1.0	-0.8	-0.5	0.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.2	0.4	0.3	-0.2	0.3	-0.3	-0.3	-0.2	-0.3	-0.6	-0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.2	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.2	-0.2	-0.2	0.1	0.5
Diff in mean of infusions in LGA sessions	1.3	1.6	1.8	1.3	1.2	1.3	-1.3	1.3	-1.3	-1.3	-1.3	-1.3	-1.0	1.1
Delay discount exponential model param	1.5	1.6	4.2	-1.0	-1.2	-1.2	1.4	-1.2	1.1	1.2	1.4	1.1	0.6	-2.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.3	0.1	0.2	-0.3	0.2	-0.2	-0.2	-0.2	-0.2	-0.1	0.0
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.2	0.3	0.2	0.2	0.3	0.3	-0.2
Bone: final force	0.3	0.5	0.7	-0.8	-0.8	-0.8	0.8	-0.7	0.7	0.7	0.7	0.7	0.6	-0.3
Bone: final moment	0.5	0.7	0.9	-0.9	-0.9	-0.9	0.9	-0.9	0.9	0.9	0.8	0.9	0.8	-0.4
Food consumed during 24 hour testing period	4.8	6.6	7.6	2.5	2.8	2.6	-2.5	2.7	-2.7	-2.7	-2.4	-2.7	-2.7	1.6
Glucose	0.2	0.4	0.7	0.8	0.5	0.6	-0.9	0.6	-0.5	-0.5	-0.8	-0.5	0.3	0.4
Heart weight	2.2	3.3	4.0	-1.8	-2.0	-1.9	1.8	-1.8	1.8	1.9	1.8	1.8	2.0	-1.5
Delay discount hyperbolic model param	1.3	1.5	4.1	-0.9	-1.2	-1.1	1.4	-1.1	1.1	1.1	1.4	1.1	0.4	-2.0
Intermittent access intake day 1-15 change	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.4	-0.3	0.3	0.3	0.4	0.3	0.6	-0.3
Intermittent access intake escalation	0.1	0.2	0.4	-0.5	-0.5	-0.5	0.5	-0.4	0.4	0.4	0.5	0.4	0.6	-0.4
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.0	0.0	0.0	0.1	0.0	0.2	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.0	-0.0	0.0	0.0	0.0	0.0	0.2	0.0
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.0	-0.1	0.0	0.1	0.0	0.0	-0.0	-0.0
Intermitt. access escalation Index	0.2	0.3	0.5	0.6	0.6	0.5	-0.5	0.5	-0.5	-0.5	-0.5	-0.5	-0.7	0.5
Intermittent access day 1 total infusions	1.4	2.2	2.4	-1.5	-1.5	-1.5	1.5	-1.6	1.5	1.6	1.5	1.5	1.3	-1.3
Intermittent access day 15 total infusions	0.7	1.0	1.2	-1.1	-1.1	-1.0	1.0	-1.0	1.0	1.0	1.0	1.0	1.0	-0.9
Intermittent access terminal intake (last 3 days)	1.1	1.4	1.6	-1.3	-1.2	-1.2	1.2	-1.2	1.2	1.2	1.2	1.2	1.2	-1.1
Intermittent access total infusions	2.3	2.7	3.0	-1.7	-1.7	-1.7	1.7	-1.7	1.7	1.7	1.7	1.7	1.5	-1.5
Intermittent access day 1 locomotion	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.6	0.6	0.6	0.6	0.6	0.5	-0.6
Intermittent access day 15 total locomotion	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.5	-0.5	0.5	0.5	0.5	0.5	0.6	-0.4
Intermittent access total locomotion	1.6	1.9	2.1	-1.4	-1.4	-1.4	1.4	-1.4	1.4	1.4	1.4	1.4	1.3	-1.2
Intermittent access standard deviation	0.1	0.2	0.3	0.4	0.4	0.5	-0.5	0.4	-0.4	-0.4	-0.5	-0.4	-0.1	0.6
Left kidney weight	5.2	24.1	28.8	-5.2	-5.0	-5.1	5.3	-4.8	4.8	4.8	5.4	4.9	3.7	-4.9
Right kidney weight	4.8	21.6	25.3	-4.9	-4.7	-4.8	4.9	-4.6	4.6	4.6	5.0	4.6	3.6	-4.6
Cocaine induced anxiety	0.2	0.2	0.4	0.6	0.5	0.5	-0.6	0.4	-0.4	-0.4	-0.6	-0.4	-0.3	0.7
Post-drug Anxiety	0.0	0.1	0.3	0.3	0.1	0.2	-0.3	0.1	-0.1	-0.1	-0.3	-0.1	0.0	0.5
Baseline Anxiety	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	-0.0	0.0	0.0	0.0	0.0	0.1	0.1
Tail length	0.3	1.3	2.0	-1.3	-1.2	-1.2	1.2	-1.2	1.2	1.2	0.9	1.2	1.4	-0.2
Length with tail	0.3	1.2	1.7	-1.3	-1.1	-1.2	1.3	-1.1	1.1	1.1	1.1	1.1	0.9	-0.4
Length without tail	0.3	0.9	1.6	-1.2	-1.0	-1.0	1.1	-0.9	0.9	0.9	1.3	0.9	0.2	-0.8
Times rat made contact with spout	0.1	0.1	0.6	0.0	0.2	0.1	0.1	0.1	-0.1	-0.1	0.2	-0.1	-0.7	-0.3
Lifetime Intake	2.2	2.7	2.9	-1.7	-1.7	-1.7	1.7	-1.7	1.7	1.7	1.7	1.7	1.5	-1.3
Liver weight, left	2.0	3.3	3.9	-1.9	-1.8	-1.9	1.7	-2.0	2.0	2.0	1.7	2.0	1.8	-1.2
Liver weight, right	1.2	2.0	2.8	-1.6	-1.4	-1.5	1.7	-1.5	1.5	1.5	1.6	1.5	0.8	-1.0
Locomotor activity	2.2	3.4	7.3	-1.9	-2.0	-1.9	1.8	-1.7	1.8	1.7	1.6	1.9	2.7	-1.0
Locomotor testing distance	1.2	2.1	5.3	-1.5	-1.6	-1.5	1.4	-1.2	1.4	1.2	1.2	1.4	2.3	-0.7
Locomotor testing rearing	4.1	8.3	9.3	-3.0	-3.0	-3.0	2.8	-2.9	2.9	2.9	2.9	3.0	3.1	-2.2
Locomotion in novel chamber	0.1	0.2	0.3	0.4	0.4	0.4	-0.4	0.4	-0.5	-0.4	-0.4	-0.5	-0.5	-0.1
Locomotion in novel chamber post-restriction	0.7	1.2	1.7	1.0	1.1	1.1	-1.1	1.2	-1.1	-1.2	-1.1	-1.1	-0.6	1.3
Fecal boli incidents, locomotor time 1	0.0	0.1	0.3	-0.1	-0.3	-0.2	0.1	-0.2	0.3	0.2	0.1	0.3	0.6	-0.2
Change in fecal boli incidents, locomotor task	0.9	0.9	2.1	0.8	0.9	0.9	-1.1	0.9	-0.9	-0.9	-1.0	-0.9	-0.3	1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.7	0.1	0.1	0.0	0.3	0.0	-0.1	-0.0	0.3	-0.1	-0.8	-0.6
Bouts of movement, locomotor time 1	2.3	2.6	3.7	1.4	1.7	1.6	-1.5	1.6	-1.7	-1.6	-1.4	-1.7	-1.9	1.4
Total resting periods, locomotor time 1	3.0	3.3	3.7	1.6	1.9	1.9	-1.7	1.8	-1.9	-1.8	-1.7	-1.9	-1.9	1.7
Rest time, locomotor task time 1	0.1	0.2	0.3	0.4	0.4	0.5	-0.3	0.5	-0.5	-0.5	-0.3	-0.6	-0.3	-0.1
Distance moved, locomotor task time 1	0.3	0.5	0.8	-0.6	-0.7	-0.7	0.5	-0.7	0.8	0.7	0.5	0.8	0.9	-0.4
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.2	-0.0	0.1	-0.3	0.1	-0.1	-0.1	-0.3	-0.0	0.5	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	0.2	0.3	-0.4	0.2	-0.2	-0.2	-0.4	-0.2	0.3	0.4
Bouts of movement, locomotor time 2	4.4	7.0	8.8	2.5	2.8	2.7	-2.5	2.7	-2.7	-2.7	-2.5	-2.7	-3.0	2.1
Total resting periods, locomotor time 2	3.5	6.1	8.4	2.4	2.7	2.5	-2.3	2.6	-2.6	-2.6	-2.3	-2.6	-2.9	1.8
Rest time, locomotor task time 2	0.1	0.1	0.6	0.0	0.2	0.2	0.1	0.2	-0.2	-0.2	0.1	-0.2	-0.8	-0.1
Distance moved, locomotor task time 2	0.7	0.8	2.1	-0.8	-0.9	-0.9	0.6	-0.9	1.0	0.9	0.6	1.0	1.4	-0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.4	0.2	0.3	-0.6	0.3	-0.3	-0.3	-0.7	-0.3	0.6	0.8
Light reinforcement 1	0.1	0.1	0.5	-0.4	-0.3	-0.4	0.7	-0.3	0.3	0.3	0.5	0.3	0.1	-0.3
Light reinforcement 2	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.5	-0.2	0.2	0.2	0.3	0.2	0.5	-0.5
Bone: marrow area	0.0	0.0	0.1	0.2	0.1	0.2	-0.0	0.2	-0.2	-0.2	-0.1	-0.2	-0.3	-0.3
Bone: maximum diameter	2.2	4.1	4.6	-2.0	-2.2	-2.0	2.0	-2.0	2.0	2.0	2.1	2.0	1.9	-2.1
Bone: maximum force	0.1	0.2	0.4	-0.6	-0.5	-0.5	0.6	-0.4	0.4	0.4	0.4	0.4	0.6	-0.1
Bone: maximum moment	0.2	0.3	0.7	-0.7	-0.7	-0.6	0.7	-0.5	0.5	0.5	0.5	0.5	0.8	-0.1
Mean time between licks in bursts	0.1	0.3	2.1	0.0	0.3	0.3	-0.4	0.3	-0.3	-0.3	-0.4	-0.3	0.1	1.4
Mean num. licks in bursts	2.6	4.0	10.1	1.8	2.2	1.9	-1.3	2.2	-2.2	-2.2	-1.3	-2.2	-3.2	0.7
Cd content in liver	0.1	0.1	1.1	0.2	0.3	0.2	-0.0	0.3	-0.3	-0.3	0.1	-0.3	-1.0	-0.2
Co content in liver	1.2	1.4	1.8	1.3	1.2	1.2	-1.4	1.2	-1.2	-1.2	-1.3	-1.2	-0.8	1.0
Cu content in liver	0.2	0.3	0.5	-0.5	-0.6	-0.6	0.5	-0.7	0.6	0.6	0.5	0.6	0.4	0.1
Fe content in liver	4.9	6.0	11.1	-2.5	-2.6	-2.5	2.2	-2.5	2.6	2.6	2.0	2.6	3.3	-0.8
K content in liver	0.2	0.2	0.7	-0.3	-0.4	-0.3	-0.0	-0.5	0.4	0.4	0.1	0.4	0.4	0.8
Mg content in liver	0.5	0.6	1.3	-0.7	-0.8	-0.7	0.4	-0.8	0.8	0.8	0.5	0.8	1.2	0.5
Mn content in liver	0.8	0.9	1.1	-0.9	-1.0	-1.0	0.9	-1.0	1.0	1.0	1.0	1.0	0.5	-0.7
Na content in liver	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.2	-0.6	0.5	0.4	0.1	0.4	0.4	0.4
Rb content in liver	0.1	0.1	0.4	-0.4	-0.2	-0.3	0.4	-0.3	0.2	0.2	0.6	0.2	-0.6	-0.4
Se content in liver	3.8	4.5	9.2	-2.1	-2.2	-2.1	1.9	-2.2	2.2	2.2	1.6	2.2	3.0	-0.7
Sr content in liver	0.1	0.1	0.8	-0.0	-0.2	-0.1	0.1	-0.2	0.2	0.2	-0.1	0.2	0.9	0.5
Zn content in liver	0.6	0.6	1.0	-0.7	-0.9	-0.9	0.8	-1.0	1.0	0.9	0.8	0.9	0.1	-0.3
Bone: minimum diameter	0.2	0.3	0.5	-0.6	-0.6	-0.6	0.7	-0.6	0.5	0.5	0.5	0.5	0.5	-0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.2	-0.5	-0.4	0.4	-0.4	0.4	0.4	0.3	0.4	0.5	-0.6
Time in novel zone, hab. session 1	0.5	0.5	0.8	-0.9	-0.7	-0.7	0.6	-0.8	0.8	0.8	0.7	0.8	0.7	-0.2
Total zone transitions, hab. session 1	0.2	0.2	0.5	-0.7	-0.4	-0.5	0.7	-0.4	0.4	0.4	0.7	0.4	0.1	-0.5
Total locomotion distance, hab. session 1	0.4	0.6	1.6	0.4	0.8	0.7	-0.7	0.7	-0.7	-0.7	-0.8	-0.7	-0.3	1.3
Locomotion velocity, hab. session 1	1.2	1.7	3.3	1.0	1.4	1.3	-1.3	1.3	-1.3	-1.3	-1.3	-1.3	-0.8	1.8
Time in familiar zone, hab. session 2	0.4	0.4	0.9	-0.6	-0.5	-0.5	0.3	-0.7	0.7	0.7	0.2	0.7	0.9	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.5	0.3	0.2	0.2	-0.2	0.3	-0.3	-0.3	0.0	-0.3	-0.7	-0.6
Total zone transitions, hab. session 2	0.5	0.6	1.2	-0.8	-0.8	-0.8	0.7	-0.8	0.8	0.8	0.6	0.8	1.1	-0.2
Total locomotion distance, hab. session 2	0.6	0.7	1.8	0.8	0.8	0.8	-0.9	0.7	-0.7	-0.7	-1.0	-0.7	-0.5	1.4
Locomotion velocity, hab. session 2	0.3	0.5	1.1	0.6	0.7	0.7	-0.7	0.6	-0.6	-0.6	-0.8	-0.6	-0.3	1.0
Novel to familiar place preference ratio	0.8	0.9	3.2	-0.9	-0.7	-0.9	1.3	-0.5	0.6	0.5	1.3	0.6	-0.4	-1.8
Novelty place preference	0.7	0.8	2.8	-0.9	-0.7	-0.8	1.2	-0.5	0.5	0.5	1.3	0.5	-0.3	-1.7
Time in novel zone, NPP test	0.9	0.9	2.9	-0.9	-0.8	-0.9	1.2	-0.6	0.7	0.6	1.3	0.7	-0.2	-1.7
Total zone transitions, NPP test	0.1	0.1	0.3	-0.3	-0.4	-0.4	0.4	-0.3	0.3	0.3	0.3	0.3	0.5	-0.3
Total locomotion distance, NPP test	0.1	0.1	0.1	-0.3	-0.4	-0.4	0.4	-0.3	0.3	0.3	0.4	0.3	0.4	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.4	-0.2	0.2	0.2	0.4	0.2	0.3	-0.4
Intraocular pressure	0.0	0.0	0.1	0.1	-0.0	0.0	-0.1	-0.0	0.0	0.1	0.0	0.0	-0.1	0.4
Delta distance traveled before/after self-admin	1.7	1.8	2.1	1.4	1.3	1.4	-1.4	1.4	-1.4	-1.4	-1.4	-1.4	-1.0	0.8
Delta ambulatory time before/after self-admin	0.3	0.4	0.5	0.7	0.6	0.7	-0.7	0.7	-0.7	-0.7	-0.7	-0.7	-0.4	0.3
Parametrial fat weight	0.1	0.1	0.4	-0.3	-0.4	-0.4	0.3	-0.3	0.4	0.3	0.4	0.4	0.1	-0.7
Pavlov. Cond. lever latency	0.5	0.6	0.9	0.7	0.7	0.8	-0.8	0.9	-0.9	-0.9	-0.9	-0.9	0.2	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.2	-0.4	0.4	0.4	0.4	0.4	-0.5	0.3
Pavlov. Cond. change in total contacts	0.6	0.6	1.7	0.8	0.8	0.8	-0.7	0.7	-0.7	-0.7	-0.6	-0.7	-1.3	0.5
Pavlov. Cond. index score	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.5	-0.7	0.7	0.7	0.6	0.7	-0.2	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.2	-0.4	0.4	0.4	0.3	0.4	-0.4	0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.5	-0.5	-0.6	0.6	-0.7	0.7	0.7	0.7	0.7	-0.3	-0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.0	0.0	0.1	0.0	0.3	-0.3	-0.3	-0.1	-0.3	0.6	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	1.0	-0.3	-0.3	-0.3	0.3	-0.2	0.2	0.2	0.4	0.2	0.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.6	-0.5	-0.5	-0.6	0.5	-0.7	0.7	0.8	0.6	0.7	-0.1	-0.1
Pavlov. Cond. response bias	0.8	1.0	1.4	-1.0	-0.9	-1.0	1.0	-1.1	1.1	1.2	1.2	1.1	-0.2	-0.5
Pavlov. Cond. lever latency	0.0	0.0	0.2	0.2	0.2	0.1	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.4	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.8	-0.2	-0.1	-0.1	0.3	0.0	-0.0	0.0	0.6	0.0	-0.9	-0.8
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	0.3	0.5	0.5	-0.4	0.6	-0.6	-0.6	-0.3	-0.6	-0.6	0.9
Pavlov. Cond. index score	0.0	0.0	0.2	-0.0	0.1	0.1	-0.1	0.3	-0.2	-0.2	0.2	-0.2	-0.5	0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	0.3	0.2	-0.2	0.4	-0.4	-0.3	-0.0	-0.3	-0.5	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.2	-0.2	0.2	0.3	0.4	0.3	0.4	-0.1
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	-0.5	-0.6	-0.6	0.5	-0.8	0.7	0.7	0.2	0.7	1.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.0	-0.1	0.1	0.1	-0.1	0.1	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.1	0.1	-0.1	-0.0	0.3	-0.0	-0.3	0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.0	-0.0	0.0	-0.0	0.1	-0.1	-0.1	0.2	-0.1	-0.2	0.0
Time in closed arm before self-admin	0.7	0.9	1.3	-1.1	-1.0	-1.0	1.1	-0.9	0.9	0.9	1.0	0.9	1.0	-0.6
Time in closed arm after self-admin	0.7	0.8	1.0	0.8	1.0	0.9	-0.8	0.9	-0.9	-0.9	-0.9	-0.9	-0.8	0.6
Time in open arm before self-admin	0.7	0.8	1.2	1.1	0.9	1.0	-1.0	0.8	-0.8	-0.8	-1.0	-0.8	-1.1	0.3
Time in open arm after self-admin	0.1	0.1	0.2	0.5	0.2	0.4	-0.4	0.3	-0.3	-0.3	-0.4	-0.3	-0.1	0.3
Bone: periosteal estimation	0.2	0.5	0.7	-0.7	-0.8	-0.7	0.9	-0.7	0.6	0.7	0.7	0.6	0.7	-0.7
Bone: periosteal perimeter	0.3	0.5	1.0	-0.7	-0.7	-0.7	0.6	-0.6	0.6	0.7	0.6	0.7	1.0	-0.3
Bone: post-yield work	0.7	1.1	1.9	0.8	1.1	1.0	-0.9	1.2	-1.2	-1.1	-1.0	-1.1	-0.6	1.4
Progressive ratio test 1 active lever presses	2.4	3.0	3.3	-1.8	-1.8	-1.8	1.8	-1.8	1.8	1.8	1.8	1.8	1.5	-1.5
Progressive ratio test 1 breakpoint	2.2	2.6	2.9	-1.7	-1.7	-1.7	1.7	-1.7	1.7	1.7	1.6	1.7	1.4	-1.4
Progressive ratio test 1 inactive lever presses	1.2	1.8	2.0	-1.4	-1.4	-1.4	1.3	-1.3	1.3	1.3	1.3	1.3	1.4	-1.1
Progressive ratio test 2 active lever presses	2.1	2.5	2.9	-1.6	-1.7	-1.6	1.5	-1.7	1.7	1.7	1.5	1.7	1.6	-1.0
Progressive ratio test 2 breakpoint	2.4	2.7	3.2	-1.7	-1.7	-1.7	1.6	-1.8	1.8	1.8	1.6	1.8	1.6	-1.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	-0.4	-0.5	-0.4	0.3	-0.5	0.5	0.5	0.3	0.5	0.6	0.0
Incentive Sensitization - Responses	1.0	1.5	1.8	-1.2	-1.3	-1.2	1.1	-1.3	1.3	1.3	1.2	1.3	1.2	-0.6
Incentive Sensitization - Breakpoint	1.0	1.3	1.6	-1.1	-1.2	-1.2	1.1	-1.3	1.3	1.3	1.1	1.3	1.1	-0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.5	0.4	0.5	-0.5	0.5	-0.5	-0.5	-0.5	-0.5	-0.3	0.4
Progressive ratio	0.9	1.4	2.0	1.4	1.2	1.3	-1.2	1.1	-1.1	-1.1	-1.3	-1.1	-1.0	0.9
Food seeking constrained by brief footshock	5.1	6.2	7.2	2.4	2.6	2.6	-2.4	2.7	-2.7	-2.7	-2.4	-2.6	-2.0	2.3
Seeking ratio, punishment vs. effort	0.6	0.9	1.3	0.7	1.0	0.9	-0.9	1.1	-1.1	-1.1	-0.7	-1.1	-0.8	0.9
Retroperitoneal fat weight	0.0	0.2	0.7	-0.0	-0.3	-0.3	0.3	-0.4	0.4	0.4	0.3	0.4	0.0	-0.9
Reaction time number correct	3.7	7.0	8.5	-2.9	-2.7	-2.8	2.7	-2.8	2.7	2.7	2.7	2.7	2.3	-2.0
Reaction time mean minus median	0.1	0.2	0.6	0.4	0.3	0.3	-0.3	0.3	-0.4	-0.3	-0.1	-0.4	-0.8	-0.5
Reaction time mean minus median AUC	0.1	0.3	1.6	-0.3	-0.4	-0.4	0.5	-0.4	0.3	0.4	0.7	0.3	-0.4	-1.3
Reaction time num false alarms	3.9	5.5	6.6	-2.4	-2.4	-2.4	2.5	-2.6	2.5	2.5	2.5	2.5	1.6	-1.8
Reaction time num false alarms AUC	3.0	4.7	6.0	-2.2	-2.2	-2.3	2.3	-2.4	2.4	2.4	2.2	2.3	1.6	-1.4
Reaction time trials correct on left	3.7	7.0	8.5	-2.9	-2.7	-2.8	2.7	-2.8	2.7	2.7	2.7	2.7	2.3	-2.0
Reaction time trials on left	3.7	7.0	8.4	-2.9	-2.7	-2.8	2.7	-2.8	2.7	2.7	2.7	2.7	2.2	-2.0
Reaction time mean	1.1	1.8	3.5	1.5	1.4	1.3	-1.1	1.4	-1.5	-1.4	-1.0	-1.5	-1.9	-0.1
Reaction time mean AUC	0.9	1.4	3.3	1.3	1.2	1.2	-0.9	1.2	-1.3	-1.2	-0.8	-1.3	-1.8	-0.1
Median of all reaction times	1.5	2.1	3.5	1.6	1.5	1.5	-1.2	1.6	-1.6	-1.5	-1.2	-1.6	-1.9	0.1
Reaction time omissions	0.2	0.3	1.8	0.2	0.0	-0.0	0.1	0.1	-0.1	-0.0	0.3	-0.1	-1.0	-1.3
Reaction time false alarm rate	0.1	0.1	0.3	-0.3	-0.4	-0.4	0.3	-0.5	0.5	0.5	0.4	0.5	0.3	-0.1
Reaction time premature initiation rate	0.4	0.6	1.1	0.8	0.8	0.8	-0.7	0.8	-0.8	-0.8	-0.5	-0.8	-1.0	0.1
Reaction time premature initiations	0.2	0.4	0.8	-0.7	-0.6	-0.7	0.7	-0.6	0.6	0.6	0.8	0.6	-0.0	-0.9
Std. dev. reaction times	0.2	0.3	0.9	0.6	0.5	0.5	-0.5	0.5	-0.6	-0.5	-0.4	-0.6	-1.0	-0.4
Reaction time trials completed	3.7	7.0	8.4	-2.9	-2.7	-2.8	2.7	-2.8	2.7	2.7	2.7	2.7	2.2	-2.0
Reaction time trials AUC	4.5	8.5	10.2	-3.2	-3.0	-3.0	3.0	-3.0	3.0	3.0	3.0	3.0	2.4	-2.3
Run reversals in cocaine runway, females	0.3	0.3	0.3	0.5	0.5	0.5	-0.5	0.6	-0.6	-0.6	-0.5	-0.6	-0.4	0.0
Run reversals in cocaine runway, males	0.5	0.5	1.2	-0.5	-0.7	-0.7	0.7	-0.7	0.7	0.7	0.7	0.7	0.3	-1.1
Latency to leave start box in cocaine runway	0.2	0.2	1.1	-0.4	-0.2	-0.3	0.6	-0.2	0.2	0.2	0.5	0.2	-0.1	-1.1
Latency to leave start box in cocaine runway, F	0.8	0.9	2.2	-0.9	-0.9	-0.9	1.1	-0.9	0.9	0.9	1.0	0.9	0.6	-1.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	0.2	0.4	0.3	-0.1	0.5	-0.4	-0.5	-0.1	-0.4	-0.8	-0.1
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.3	0.0	-0.1	0.4	-0.1	0.1	0.1	0.3	0.1	-0.5	0.3
Total sessions with >9 infusions	3.6	4.3	4.8	-2.2	-2.1	-2.2	2.1	-2.2	2.2	2.2	2.1	2.2	1.9	-1.7
Short access day 1 total inactive lever presses	0.4	0.6	0.7	-0.7	-0.8	-0.8	0.7	-0.7	0.8	0.7	0.7	0.8	0.8	-0.6
Short access day 10 total inactive lever presses	0.6	1.4	1.6	1.2	1.1	1.2	-1.2	1.2	-1.2	-1.2	-1.2	-1.2	-0.8	1.2
Short access day 1 total infusions	1.8	2.4	2.8	-1.6	-1.6	-1.6	1.6	-1.7	1.7	1.7	1.6	1.6	1.3	-1.2
Short access day 10 total infusions	3.4	4.3	4.7	-2.2	-2.1	-2.2	2.1	-2.1	2.1	2.1	2.1	2.1	1.8	-1.8
Short access total infusions	2.1	2.6	3.0	-1.7	-1.7	-1.7	1.6	-1.7	1.7	1.7	1.6	1.7	1.4	-1.2
Short access day 1 locomotion	3.1	3.8	4.1	-2.0	-2.0	-2.0	2.0	-2.0	2.0	2.0	2.0	2.0	1.6	-1.8
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.1	0.0	-0.0	-0.0	0.1	-0.0	-0.1	-0.3
Short access total locomotion	0.7	0.8	1.0	-1.0	-0.9	-0.9	1.0	-0.9	0.9	0.9	1.0	0.9	0.7	-1.0
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.1	0.1	0.1	0.2	0.1	0.3	-0.3
Compulsive drug intake	0.2	0.3	0.9	-0.6	-0.5	-0.5	0.6	-0.3	0.4	0.3	0.6	0.4	0.2	-1.0
One hour access (shock baseline)	0.8	1.2	1.3	-1.1	-1.1	-1.1	1.1	-1.1	1.1	1.1	1.1	1.1	1.1	-0.9
Social response proportion	1.1	1.2	1.9	-1.2	-0.9	-1.1	1.3	-1.1	1.0	1.1	1.4	1.0	-0.3	-1.3
Social responses	0.8	1.1	1.5	-0.9	-1.0	-1.1	1.2	-1.1	1.1	1.1	1.2	1.1	0.2	-1.2
Social time	3.1	4.3	4.6	2.1	2.1	2.1	-2.1	2.1	-2.1	-2.1	-2.0	-2.2	-2.0	1.8
Soleus weight	0.1	0.3	0.6	-0.7	-0.6	-0.6	0.8	-0.5	0.5	0.5	0.7	0.5	0.0	-0.5
Bone: stiffness	0.7	1.2	2.4	-1.2	-1.2	-1.1	1.1	-1.0	1.0	1.0	1.0	1.0	1.6	-0.7
Tibialis anterior weight	3.0	10.2	13.0	-3.2	-3.3	-3.4	3.6	-3.3	3.3	3.2	3.5	3.2	1.8	-3.2
Time to tail flick, vehicle, before self-admin	3.0	3.1	3.2	-1.7	-1.8	-1.8	1.8	-1.8	1.8	1.8	1.7	1.8	1.6	-1.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.2	0.2	0.2	0.1	0.2	0.1	0.0
Time to tail flick, test, before self-admin	0.4	0.4	0.7	0.8	0.7	0.7	-0.7	0.6	-0.6	-0.6	-0.6	-0.6	-0.8	0.5
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.5	0.5	0.4	-0.4	0.3	-0.3	-0.3	-0.5	-0.3	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.3	0.4	0.3	-0.3	0.3	-0.3	-0.3	-0.3	-0.3	-0.4	0.5
Delta time to tail flick, test, before/after SA	0.8	0.8	1.3	-1.0	-0.9	-0.9	1.0	-0.9	0.9	0.9	0.8	0.9	1.2	-0.8
Tibia length	0.2	0.6	1.2	-0.8	-0.8	-0.8	0.6	-0.6	0.7	0.9	0.9	0.8	1.1	-0.4
Ambulatory time before self-admin	0.0	0.0	0.3	0.0	0.1	0.0	-0.1	0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.6
Ambulatory time after self-admin	0.4	0.5	0.7	0.7	0.7	0.7	-0.7	0.7	-0.7	-0.7	-0.7	-0.7	-0.3	0.9
Bone: tissue strength	0.8	0.9	0.9	0.9	0.9	0.9	-0.9	1.0	-1.0	-1.0	-0.8	-1.0	-0.9	0.9
Total heroin consumption	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	-0.1	-0.1	-0.1	-0.0	0.2
Bone: trabecular number	0.1	0.2	1.2	0.1	0.4	0.3	-0.0	0.3	-0.3	-0.3	0.0	-0.3	-1.1	0.5
Bone: trabecular spacing	0.0	0.1	0.1	-0.0	-0.3	-0.2	-0.0	-0.3	0.3	0.2	0.1	0.3	0.0	-0.4
Bone: trabecular thickness	1.3	1.6	2.3	-1.4	-1.3	-1.3	1.5	-1.3	1.3	1.3	1.4	1.3	0.7	-1.0
Bone: trabecular tissue density	0.4	0.6	0.9	-0.7	-0.7	-0.7	0.6	-0.7	0.7	0.8	0.7	0.8	0.9	-0.8
Water consumed over 24 hours	0.2	0.2	1.1	0.3	0.5	0.4	-0.1	0.5	-0.5	-0.5	-0.1	-0.5	-1.1	-0.0
Number of responses in last shaping day	2.8	3.1	3.5	-1.9	-1.8	-1.8	1.8	-1.8	1.8	1.8	1.8	1.8	1.5	-1.4