Hub : Genes

Vars1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Vars1 0.15 0.06 4.9e-14 0.09 0.14 0.15 0.14 1.1e-09 7.8e-15 2.7e-16 4.0e-15
2 NAcc mRNA stability Vars1 0.07 0.04 1.7e-10 0.03 0.06 0.06 0.06 9.9e-06 6.4e-10 3.8e-09 2.7e-09
3 pVTA mRNA stability Vars1 0.09 0.05 1.5e-06 0.09 0.08 0.08 0.09 1.2e-07 4.7e-07 2.8e-07 2.5e-07
4 Brain mRNA stability Vars1 0.12 0.06 3.7e-11 0.12 0.13 0.12 0.12 7.6e-11 7.7e-12 1.1e-11 1.6e-11
5 BLA gene expression Vars1 0.11 0.1 3.0e-03 0.05 0.03 0.02 0.04 1.3e-03 1.5e-02 2.4e-02 4.5e-03
6 PL gene expression Vars1 0.05 0.03 1.3e-06 0.06 0.05 0.04 0.05 8.0e-07 1.6e-06 3.0e-05 3.0e-06
7 NAcc gene expression Vars1 0.04 0.03 5.7e-07 0.05 0.04 0.04 0.04 7.7e-08 1.5e-06 4.9e-06 1.5e-06
8 Adipose gene expression Vars1 0.09 0.05 2.9e-05 0.03 0.04 0.03 0.03 3.8e-04 2.6e-05 3.3e-04 2.0e-04
9 PL mRNA stability Vars1 0.03 0.02 6.4e-03 0.01 0.01 0 0 4.3e-02 4.6e-02 2.5e-01 1.4e-01
10 pVTA gene expression Vars1 0.08 0.04 3.2e-05 0.06 0.06 0.06 0.06 8.1e-06 8.8e-06 3.2e-05 2.2e-05
11 IC mRNA stability Vars1 0.07 0.05 4.3e-03 0.06 0.06 0.05 0.04 1.8e-03 2.4e-03 3.6e-03 5.5e-03
12 Brain gene expression Vars1 0.27 0.12 3.9e-16 0.13 0.12 0.11 0.13 6.4e-12 2.6e-11 1.3e-10 4.9e-12
13 Liver gene expression Vars1 0.08 0.04 1.2e-06 0.05 0.05 0.06 0.05 2.3e-06 1.5e-06 3.6e-07 2.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.43.8-0.1-0.71.90.60.72.01.9-1.70.40.90.1-1.20.5
Area under the delay curve0.10.21.3-0.10.2-0.6-0.30.0-0.5-0.50.3-1.10.30.3-0.1-0.1
BMI with tail1.34.512.02.3-2.01.3-1.3-2.4-1.8-1.8-0.73.5-2.5-0.22.92.4
BMI without tail1.15.812.23.1-2.30.8-2.9-3.5-3.0-2.8-0.42.8-2.41.32.60.8
Body weight2.08.919.52.6-1.2-0.8-2.0-3.5-4.3-4.01.63.4-4.4-0.64.12.5
Weight adjusted by age1.23.48.01.50.0-1.2-1.0-1.8-2.7-2.61.70.8-2.7-0.42.81.7
Bone surface0.10.10.3-0.30.3-0.40.50.20.00.10.40.4-0.3-0.60.20.1
Bone volume0.10.20.80.3-0.50.70.0-0.20.30.3-0.50.9-0.2-0.10.10.4
Breakpoint value in progressive ratio session0.20.41.0-0.90.5-0.20.40.60.50.70.1-0.70.8-0.4-1.0-0.7
Number of licking bursts0.61.73.3-1.81.8-1.81.51.50.60.41.4-1.20.7-1.3-1.1-0.9
Context. condit. distance diff. score4.25.111.1-3.23.0-1.63.32.91.92.01.7-1.91.2-2.7-1.4-0.3
Locomotion velocity, session 10.70.82.8-0.91.1-0.70.60.90.50.50.6-1.71.0-0.1-0.8-1.3
Locomotion distance, session 10.60.82.6-0.6-0.01.00.70.81.51.6-0.9-0.31.1-0.0-1.00.0
Locomotion velocity, session 20.70.81.5-1.11.0-0.50.91.10.90.90.4-1.21.1-0.6-0.7-0.9
Locomotion distance, session 21.01.33.3-1.40.80.31.61.31.71.8-0.1-0.71.0-1.2-0.60.6
Locomotion velocity, session 30.50.62.20.7-0.90.8-1.1-0.7-0.5-0.2-0.90.10.51.50.1-0.8
Locomotion distance, session 31.11.23.1-1.00.30.80.81.21.51.7-0.9-1.01.70.4-1.2-0.8
Stereotopy head waving bouts, day 30.70.82.7-0.40.8-1.70.0-0.1-1.3-1.21.5-0.2-0.7-0.60.7-0.3
Stereotopy head waving duration, day 30.70.93.10.30.3-1.3-0.9-0.7-1.8-1.71.2-0.1-0.90.10.7-0.5
Locomotion velocity, session 73.03.38.3-2.11.00.92.42.22.92.9-0.7-1.31.7-1.4-1.40.7
Locomotion distance, session 73.24.111.4-1.80.91.12.02.63.23.4-1.2-1.82.5-0.4-1.9-0.3
Stereotopy head waving bouts, day 70.70.83.80.6-0.1-0.4-1.1-0.2-0.7-0.7-0.1-0.90.81.4-0.5-1.9
Stereotopy head waving duration, day 70.50.61.70.7-0.3-0.4-1.1-0.5-1.0-1.00.0-0.30.21.2-0.2-1.3
Locomotion velocity, session 83.54.39.7-2.93.1-2.82.42.10.60.42.7-2.20.8-2.1-0.7-1.2
Locomotion distance, session 84.46.315.8-3.63.0-1.14.03.32.72.81.4-1.71.3-3.2-1.20.5
Degree of sensitization distance0.70.71.7-0.91.2-1.11.10.90.40.31.1-0.6-0.0-1.30.10.0
Degree of sensitization stereotypy0.70.83.80.3-0.10.1-0.70.20.10.1-0.5-1.01.31.4-1.2-2.0
Conditioned locomotion0.60.71.60.00.4-0.80.4-0.3-0.9-0.81.10.9-1.3-1.11.11.1
Cocaine response after cond. corrected0.81.13.2-1.30.7-0.11.81.11.10.90.40.6-0.3-1.80.31.5
Cocaine response after cond. not corrected0.50.82.0-1.01.0-1.21.10.6-0.1-0.31.30.2-0.6-1.40.50.5
Cocaine response before conditioning1.92.36.91.10.1-1.7-1.8-1.6-2.6-2.51.4-0.3-0.80.90.6-1.6
Saline control response3.95.411.93.4-2.91.5-3.4-2.9-2.3-2.2-1.62.1-1.42.61.60.3
Bone: connectivity density0.60.92.7-0.4-0.21.21.10.81.61.5-0.90.60.2-0.8-0.51.1
Bone: cortical apparent density1.21.83.91.7-1.91.5-1.3-1.4-0.8-0.4-1.32.0-1.01.01.01.3
Bone: cortical area0.10.10.3-0.10.2-0.40.0-0.3-0.4-0.50.50.2-0.1-0.20.3-0.2
Bone: cortical porosity1.41.55.80.5-0.0-0.4-1.4-0.4-0.6-0.8-0.2-1.91.42.0-1.0-2.4
Bone: cortical porosity1.21.35.00.10.5-1.0-0.9-0.1-0.6-0.70.4-2.11.11.4-0.9-2.2
Bone: cortical thickness0.81.33.01.3-1.71.7-1.2-1.2-0.1-0.3-1.61.30.11.30.30.3
Bone: cortical thickness1.61.94.41.8-2.11.9-1.5-1.6-0.3-0.3-1.81.8-0.41.30.60.6
Bone: cortical tissue density1.11.73.51.6-1.81.4-1.3-1.3-0.8-0.5-1.21.9-1.01.01.01.3
Condit. Reinf. active minus inactive responses0.80.93.1-0.30.20.3-0.10.40.80.8-0.5-1.81.80.7-1.2-1.3
Condit. Reinf. active-inactive response ratio0.50.51.40.8-0.80.6-1.1-0.7-0.2-0.2-0.8-0.40.71.2-0.2-0.7
Condit. Reinf. active responses0.60.82.5-0.40.10.80.30.51.11.2-0.8-1.31.60.3-1.0-0.5
Condit. Reinf. inactive responses1.01.33.9-0.6-0.31.60.70.81.92.0-1.5-0.41.20.1-1.30.3
Incentive salience index mean1.92.45.2-1.91.7-0.61.81.81.71.70.5-2.31.8-0.9-1.4-0.9
Condit. Reinf. lever presses3.45.111.9-3.22.7-1.33.42.82.22.41.5-1.81.2-2.7-1.40.2
Condit. Reinf. active minus inactive responses0.50.72.40.5-0.1-0.6-1.1-1.1-1.5-1.50.6-0.1-0.50.50.6-0.7
Condit. Reinf. active-inactive response ratio0.61.03.20.10.5-1.3-0.7-0.8-1.7-1.81.4-0.3-0.8-0.10.8-0.6
Condit. Reinf. active responses0.20.30.80.5-0.3-0.1-0.9-0.7-0.8-0.80.10.1-0.10.80.2-0.7
Condit. Reinf. inactive responses0.30.40.90.7-0.90.9-0.6-0.50.10.2-1.00.60.20.9-0.1-0.0
Condit. Reinf. lever presses0.20.31.40.3-0.10.2-0.5-0.00.0-0.2-0.4-0.70.80.9-0.2-1.2
Condit. Reinf. lever reinforcers received0.20.31.00.3-0.1-0.2-0.8-0.5-0.7-0.70.1-0.20.20.80.0-1.0
Conditioned reinforcement - actives0.00.20.40.5-0.60.7-0.5-0.6-0.20.1-0.50.3-0.20.20.30.2
Conditioned reinforcement - inactives0.10.20.70.5-0.50.5-0.8-0.8-0.5-0.4-0.4-0.2-0.20.10.20.4
Conditioned locomotion0.00.10.30.00.1-0.0-0.0-0.3-0.3-0.20.2-0.2-0.5-0.00.30.4
Patch foraging indifference point 0 sec1.13.26.52.5-2.21.6-2.5-2.6-1.5-1.6-1.21.4-1.21.91.30.6
Patch foraging indifference point AUC0.10.31.60.30.1-0.5-0.5-0.0-0.4-0.50.1-0.60.50.8-0.4-1.3
Delay disc. indifference point, 0s delay0.60.71.7-1.21.1-1.00.90.80.10.11.0-1.0-0.0-1.3-0.10.3
Delay disc. indifference point, 16s delay0.30.41.60.9-0.80.6-0.9-0.5-0.2-0.3-0.8-0.30.31.30.10.1
Delay disc. indifference point, 2s delay0.80.92.5-1.11.0-1.5-0.2-0.0-1.1-1.01.4-1.6-0.1-0.10.1-0.4
Delay disc. indifference point, 24s delay0.40.71.51.0-0.4-0.2-1.2-0.7-1.1-1.2-0.0-0.9-0.01.20.7-0.4
Delay disc. indifference point, 4s delay0.50.51.70.20.0-0.9-0.8-0.6-1.3-1.30.7-0.5-0.30.20.3-0.4
Delay disc. indifference point, 8s delay0.10.21.5-0.20.2-0.20.10.40.10.20.0-1.20.50.1-0.6-0.0
Indifference point function ln k0.30.92.0-1.41.2-0.80.81.00.50.60.8-1.40.9-0.5-1.0-0.9
Indifference point function log k0.30.92.0-1.41.2-0.80.81.00.50.60.8-1.40.9-0.5-1.0-0.9
Patch foraging total patch changes 0 sec1.23.46.92.6-2.31.7-2.6-2.6-1.5-1.6-1.31.4-1.21.91.30.6
Patch foraging total patch changes 12 sec1.62.24.92.2-1.81.0-2.1-1.8-1.2-1.5-1.11.2-0.71.81.1-0.1
Patch foraging total patch changes 18 sec1.43.37.42.3-2.72.6-1.9-2.0-0.2-0.3-2.32.2-0.71.70.71.2
Patch foraging total patch changes 24 sec0.51.95.21.8-2.02.2-1.2-0.90.60.3-2.31.00.21.6-0.10.7
Patch foraging total patch changes 6 sec1.83.07.42.7-2.21.5-2.3-2.2-1.2-1.5-1.41.3-0.92.01.40.6
Patch foraging time to switch 0 sec0.41.66.20.7-1.01.00.1-0.9-0.0-0.0-0.62.3-1.6-0.71.72.5
Patch foraging water rate 0 sec0.00.10.40.4-0.1-0.1-0.4-0.4-0.6-0.60.3-0.1-0.50.10.30.3
Patch foraging water rate 12 sec0.10.51.50.5-0.91.2-0.4-0.10.70.8-1.20.50.50.7-0.80.1
Patch foraging water rate 18 sec0.10.30.80.9-0.60.2-0.7-0.5-0.7-0.7-0.30.5-0.50.50.60.4
Patch foraging water rate 24 sec0.20.20.60.5-0.80.7-0.6-0.4-0.1-0.1-0.60.7-0.10.6-0.10.1
Patch foraging water rate 6 sec0.10.20.60.1-0.60.6-0.3-0.10.30.4-0.60.30.10.3-0.80.3
Seeking ratio, delayed vs. immediate footshock0.60.82.50.5-0.9-0.1-1.5-0.8-0.9-0.7-0.40.50.31.5-0.4-1.6
Distance traveled before self-admin0.30.62.4-0.30.4-0.50.90.2-0.3-0.20.81.0-1.2-1.60.90.5
Distance traveled after self-admin0.50.92.40.6-0.2-0.7-0.7-0.9-1.6-1.60.71.1-1.1-0.21.2-0.5
Extensor digitorum longus weight0.20.72.1-0.71.1-1.20.80.2-0.3-0.71.40.1-0.8-1.40.60.4
Bone: elastic displacement0.50.61.70.8-0.91.0-1.1-0.5-0.0-0.1-1.1-0.40.61.3-0.6-0.4
Bone: elastic work0.10.20.50.5-0.40.3-0.7-0.6-0.5-0.6-0.2-0.1-0.20.50.20.2
Bone: endosteal estimation1.94.814.1-0.41.9-3.80.1-0.7-3.0-2.93.70.1-2.3-1.72.0-0.2
Bone: endosteal perimeter1.43.410.6-1.82.6-3.31.60.7-1.0-1.03.2-0.9-0.9-2.50.7-0.3
Epididymis fat weight3.216.333.44.9-5.85.4-3.9-4.5-1.5-1.1-4.65.6-2.42.12.54.2
Delta time in closed arm before/after self-admin0.70.71.70.30.1-0.40.0-0.6-0.8-0.90.80.7-1.3-1.01.21.1
Delta time in open arm before/after self-admin0.20.30.80.7-0.80.6-0.9-0.6-0.3-0.3-0.70.20.20.70.1-0.1
Diff in mean of infusions in LGA sessions1.42.56.9-2.31.00.32.12.02.42.6-0.3-0.41.4-1.0-1.60.2
Delay discount exponential model param0.20.31.40.0-0.20.60.50.10.60.6-0.41.2-0.3-0.50.10.3
Extinction: sum of active levers before priming0.50.81.8-1.31.3-1.01.21.10.50.31.0-1.00.3-1.0-0.3-0.3
Active lever presses in extinction session 60.20.20.50.4-0.50.7-0.5-0.40.00.0-0.6-0.30.10.2-0.00.7
Bone: final force1.32.25.21.6-1.30.5-1.1-1.7-1.5-1.6-0.22.3-1.8-0.11.91.6
Bone: final moment1.21.94.01.5-1.20.5-1.1-1.7-1.5-1.6-0.12.0-1.7-0.01.81.4
Food consumed during 24 hour testing period0.51.12.8-0.60.7-1.00.90.0-0.7-0.71.40.7-1.3-1.71.41.2
Glucose3.55.613.6-2.93.7-3.62.62.10.0-0.03.5-2.60.2-2.5-0.2-1.1
Heart weight1.22.06.21.0-0.1-1.3-1.5-1.6-2.5-2.41.2-0.1-1.40.71.3-0.4
Delay discount hyperbolic model param0.30.41.70.1-0.20.70.60.10.70.7-0.41.3-0.4-0.50.20.5
Intermittent access intake day 1-15 change0.00.21.00.5-0.30.4-0.3-0.10.20.3-0.50.20.50.7-0.4-1.0
Intermittent access intake escalation0.20.92.41.2-1.21.0-1.2-0.70.10.1-1.40.40.81.6-0.5-1.1
Intermittent access intake escalation 20.20.31.40.20.1-0.1-0.10.20.30.3-0.2-0.50.80.5-0.6-1.2
Intermitt. access day 1 inactive lever presses0.11.85.3-1.51.8-1.91.51.0-0.3-0.32.1-0.3-0.6-2.30.60.3
Intermitt. access day 15 inactive lever presses0.10.41.10.60.0-0.5-0.3-0.6-1.0-1.00.60.4-0.9-0.21.10.4
Intermitt. access escalation Index0.72.35.3-2.31.3-0.22.02.01.91.90.3-0.91.3-1.2-1.9-0.4
Intermittent access day 1 total infusions0.20.51.6-0.10.10.80.20.41.01.1-0.7-1.31.00.1-0.90.1
Intermittent access day 15 total infusions0.30.82.10.8-0.91.3-0.8-0.30.60.6-1.4-0.41.01.4-0.8-0.6
Intermittent access terminal intake (last 3 days)0.30.61.81.0-0.80.6-1.1-0.7-0.1-0.0-1.0-0.50.61.3-0.4-0.6
Intermittent access total infusions0.40.41.10.6-0.60.9-0.8-0.40.20.3-1.0-0.60.61.1-0.6-0.2
Intermittent access day 1 locomotion0.10.20.70.8-0.50.9-0.1-0.30.30.4-0.70.4-0.20.20.00.7
Intermittent access day 15 total locomotion0.20.62.11.4-0.70.4-0.7-0.9-0.7-0.6-0.20.9-0.90.40.90.4
Intermittent access total locomotion0.40.51.41.2-1.00.9-0.9-0.9-0.4-0.2-0.80.6-0.40.80.40.4
Intermittent access standard deviation0.52.66.22.5-1.70.8-2.0-2.1-1.8-1.6-0.61.7-1.41.01.71.1
Left kidney weight1.18.817.63.2-2.20.2-2.9-3.8-4.2-3.90.43.4-3.80.83.61.9
Right kidney weight1.28.116.72.8-1.9-0.1-2.3-3.5-3.9-3.60.73.5-4.10.23.62.4
Cocaine induced anxiety0.20.41.2-0.80.8-0.71.10.80.30.30.8-0.00.0-1.10.20.1
Post-drug Anxiety0.20.20.4-0.20.3-0.60.2-0.1-0.5-0.40.60.4-0.4-0.60.30.2
Baseline Anxiety0.10.10.30.2-0.3-0.1-0.5-0.5-0.6-0.50.10.2-0.40.5-0.3-0.0
Tail length0.84.513.80.80.9-2.9-1.5-1.8-3.7-3.42.9-0.2-2.10.11.7-1.1
Length with tail1.56.819.20.71.0-3.2-1.1-2.1-4.4-4.13.60.6-3.4-1.03.00.5
Length without tail1.47.418.30.60.6-2.10.1-1.8-3.6-3.43.02.3-4.3-2.53.93.0
Times rat made contact with spout1.92.15.50.8-1.42.1-1.2-0.21.10.9-2.4-0.51.82.2-1.4-1.3
Lifetime Intake0.20.30.70.5-0.60.7-0.8-0.50.00.1-0.8-0.60.40.9-0.4-0.0
Liver weight, left1.42.37.0-0.61.6-2.40.9-0.0-1.6-1.52.70.3-1.6-1.91.60.1
Liver weight, right1.72.98.5-1.02.1-2.81.00.2-1.6-1.62.9-0.7-1.3-2.31.6-0.1
Locomotor activity0.61.02.9-0.00.3-1.4-0.9-0.7-1.7-1.71.0-0.3-0.40.20.3-1.4
Locomotor testing distance0.20.61.6-0.30.5-1.1-0.2-0.5-1.3-1.11.1-0.1-0.6-0.50.5-0.6
Locomotor testing rearing0.20.92.00.20.2-0.9-0.2-0.8-1.4-1.21.10.7-1.4-1.11.30.6
Locomotion in novel chamber0.00.00.10.1-0.30.1-0.3-0.20.0-0.2-0.20.30.20.1-0.2-0.0
Locomotion in novel chamber post-restriction0.41.22.41.0-1.00.4-1.1-1.6-1.3-1.2-0.01.4-1.50.21.31.0
Fecal boli incidents, locomotor time 10.10.31.9-0.3-0.20.5-0.0-0.5-0.00.0-0.00.5-0.7-0.60.31.4
Change in fecal boli incidents, locomotor task0.90.93.2-0.61.2-1.80.80.7-0.6-0.51.7-0.5-0.6-0.90.6-0.4
Time >=10cm from walls, locomotor time 11.92.35.1-0.20.6-1.50.5-0.4-1.6-1.81.91.4-2.3-2.02.01.6
Bouts of movement, locomotor time 10.40.51.5-0.40.30.10.71.01.20.9-0.3-0.51.2-0.1-0.8-0.8
Total resting periods, locomotor time 10.30.40.9-0.50.5-0.10.70.91.00.7-0.1-0.50.9-0.1-0.5-0.6
Rest time, locomotor task time 10.10.20.5-0.60.6-0.60.0-0.1-0.4-0.60.7-0.5-0.1-0.30.2-0.3
Distance moved, locomotor task time 10.10.20.40.6-0.50.1-0.3-0.4-0.4-0.2-0.20.6-0.40.50.20.3
Vertical activity count, locomotor time 10.10.51.40.9-1.00.6-0.7-0.8-0.3-0.2-0.51.2-0.70.50.21.0
Time >=10cm from walls, locomotor time 20.51.64.1-0.30.7-1.50.2-0.6-1.7-1.51.90.3-2.0-0.91.31.2
Bouts of movement, locomotor time 20.10.31.40.00.0-0.3-0.60.0-0.2-0.40.0-0.60.90.7-0.4-1.2
Total resting periods, locomotor time 20.10.52.4-0.40.5-0.7-0.30.4-0.1-0.40.4-1.11.10.5-0.7-1.6
Rest time, locomotor task time 20.91.54.0-1.41.7-1.41.81.40.40.21.6-0.4-0.2-2.00.20.3
Distance moved, locomotor task time 20.91.12.11.4-1.20.9-0.9-1.3-0.7-0.6-0.71.1-1.31.00.91.4
Vertical activity count, locomotor time 20.30.81.91.0-0.90.4-0.8-1.1-0.8-0.6-0.20.8-1.30.51.11.4
Light reinforcement 10.10.62.70.0-0.40.40.4-0.30.00.1-0.11.7-1.2-0.50.61.3
Light reinforcement 20.30.71.7-0.20.4-0.40.8-0.0-0.4-0.40.80.9-1.1-1.21.21.3
Bone: marrow area2.04.913.6-0.21.7-3.7-0.0-0.9-3.1-3.13.70.2-2.5-1.72.2-0.1
Bone: maximum diameter1.12.25.4-1.92.3-2.31.61.1-0.0-0.12.3-1.30.2-1.7-0.2-0.8
Bone: maximum force0.71.53.01.2-0.80.1-0.7-1.4-1.3-1.50.21.7-1.6-0.21.71.4
Bone: maximum moment0.71.32.61.1-0.60.0-0.7-1.4-1.3-1.60.31.4-1.5-0.21.61.2
Mean time between licks in bursts0.42.55.5-2.12.3-2.01.81.70.60.71.9-1.60.6-1.7-1.0-1.1
Mean num. licks in bursts1.12.97.52.1-2.42.7-2.1-1.6-0.2-0.1-2.50.90.22.40.40.1
Cd content in liver0.80.85.20.4-0.71.20.2-0.30.10.4-0.61.0-0.9-0.70.72.3
Co content in liver1.41.63.31.6-1.30.8-1.1-1.6-1.2-0.9-0.41.5-1.50.21.81.7
Cu content in liver1.51.85.00.3-1.22.1-0.70.11.11.3-2.2-0.21.91.6-1.2-1.1
Fe content in liver1.01.22.41.4-1.41.2-1.1-1.2-0.6-0.5-0.91.5-1.10.40.71.2
K content in liver0.60.61.6-0.80.50.21.01.11.21.2-0.2-0.30.7-0.5-0.5-0.3
Mg content in liver2.52.75.6-2.42.2-1.62.32.01.21.41.4-1.41.0-1.7-0.7-1.1
Mn content in liver3.13.57.5-2.62.7-2.52.61.80.70.72.5-1.40.0-2.5-0.3-0.1
Na content in liver0.60.71.50.0-0.50.7-0.40.40.60.8-1.1-0.21.21.1-1.2-1.2
Rb content in liver0.30.41.3-0.40.40.01.00.60.40.70.20.4-0.4-1.10.70.7
Se content in liver3.23.87.9-2.42.6-2.41.61.80.40.51.8-2.82.1-0.8-1.3-2.6
Sr content in liver0.50.51.20.40.2-0.8-0.1-0.5-0.6-0.70.8-0.0-1.0-0.51.01.1
Zn content in liver0.30.30.8-0.60.7-0.60.70.3-0.00.20.8-0.3-0.3-0.90.70.3
Bone: minimum diameter1.22.37.1-1.52.1-2.51.30.4-0.9-0.92.7-0.4-1.0-2.20.80.1
Time in familiar zone, hab. session 11.92.16.80.8-1.62.4-1.0-0.21.41.3-2.6-0.11.41.9-1.0-0.6
Time in novel zone, hab. session 11.41.64.7-0.21.1-2.00.3-0.4-1.6-1.62.20.3-1.5-1.11.10.4
Total zone transitions, hab. session 10.30.51.2-0.80.50.00.80.81.01.1-0.0-0.30.7-0.5-0.6-0.5
Total locomotion distance, hab. session 10.40.51.6-0.80.50.21.00.81.21.3-0.1-0.10.5-0.9-0.4-0.0
Locomotion velocity, hab. session 10.20.31.0-0.60.40.10.70.60.91.0-0.0-0.10.5-0.6-0.3-0.3
Time in familiar zone, hab. session 20.60.71.90.9-1.31.2-0.8-0.50.20.3-1.40.90.40.90.2-0.4
Time in novel zone, hab. session 20.20.20.60.20.3-0.6-0.3-0.4-0.7-0.80.6-0.4-0.60.10.10.3
Total zone transitions, hab. session 20.30.30.8-0.60.10.30.80.50.80.9-0.10.7-0.1-0.9-0.10.5
Total locomotion distance, hab. session 20.91.23.3-1.20.40.51.61.21.81.8-0.30.40.4-1.5-0.60.7
Locomotion velocity, hab. session 21.31.74.2-1.60.80.31.91.62.02.1-0.10.00.7-1.6-0.90.4
Novel to familiar place preference ratio0.10.10.50.00.10.0-0.00.40.30.5-0.2-0.60.50.3-0.7-0.4
Novelty place preference0.10.10.50.10.2-0.2-0.20.30.20.3-0.1-0.70.40.4-0.6-0.6
Time in novel zone, NPP test0.10.10.50.20.1-0.2-0.30.1-0.00.1-0.0-0.70.30.4-0.5-0.7
Total zone transitions, NPP test0.81.23.0-1.30.80.21.61.41.71.7-0.1-0.40.7-1.0-0.70.2
Total locomotion distance, NPP test0.91.33.4-1.10.60.61.71.21.61.8-0.20.00.1-1.5-0.31.4
Locomotion velocity, NPP test1.42.05.5-1.50.70.72.11.62.12.3-0.3-0.10.4-1.7-0.61.4
Intraocular pressure0.40.72.40.8-1.11.6-0.2-0.20.70.7-1.30.9-0.20.70.10.7
Delta distance traveled before/after self-admin1.21.33.71.1-0.7-0.4-1.9-1.4-1.7-1.80.1-0.3-0.11.50.4-1.2
Delta ambulatory time before/after self-admin0.50.92.30.7-0.3-0.6-1.5-1.0-1.5-1.50.4-0.4-0.01.20.4-1.2
Parametrial fat weight1.53.610.41.9-1.91.6-0.9-1.8-1.2-0.9-1.03.2-2.3-0.22.52.8
Pavlov. Cond. lever latency4.45.610.33.1-3.01.9-2.6-2.9-1.9-1.9-1.73.2-2.01.52.31.9
Pavlov. Cond. magazine entry latency2.73.48.0-2.02.0-1.41.21.91.21.40.9-2.82.2-0.2-2.4-2.6
Pavlov. Cond. change in total contacts1.51.64.1-1.51.5-1.20.81.20.50.50.9-2.01.5-0.2-1.5-1.9
Pavlov. Cond. index score4.35.510.5-3.02.9-1.92.32.71.81.81.5-3.22.2-1.2-2.5-2.2
Pavlov. Cond. latency score4.65.810.7-3.13.0-2.02.42.91.91.91.6-3.32.2-1.3-2.6-2.3
Pavlov. Cond. lever contacts4.25.09.8-3.13.0-2.02.82.71.71.71.9-2.71.4-2.0-1.8-1.1
Pavlov. Cond. magazine entry number1.82.25.21.6-1.61.1-1.0-1.5-1.0-1.0-0.72.3-1.80.21.92.1
Pavlov. Cond. intertrial magazine entries1.21.43.91.2-1.72.0-0.8-1.1-0.1-0.0-1.61.4-0.60.80.61.6
Pavlov. Cond. lever-magazine prob. diff.4.35.310.3-3.02.8-1.82.32.71.81.91.4-3.22.3-1.2-2.6-2.2
Pavlov. Cond. response bias3.03.87.7-2.52.4-1.61.92.21.41.51.3-2.81.9-1.0-2.1-1.9
Pavlov. Cond. lever latency0.50.72.1-1.11.0-1.01.10.5-0.10.31.20.2-0.8-1.4-0.20.7
Pavlov. Cond. magazine entry latency0.10.20.6-0.30.6-0.30.30.40.3-0.00.3-0.80.2-0.50.2-0.3
Pavlov. Cond. change in total contacts0.20.61.91.0-0.70.4-1.2-0.6-0.4-0.7-0.6-0.30.41.40.2-1.0
Pavlov. Cond. index score0.10.20.60.5-0.20.1-0.5-0.10.0-0.4-0.3-0.60.50.70.4-0.8
Pavlov. Cond. latency score0.20.20.50.7-0.30.2-0.7-0.3-0.2-0.5-0.4-0.40.30.70.5-0.7
Pavlov. Cond. lever contacts0.40.61.61.1-0.90.9-1.0-0.6-0.0-0.3-1.1-0.10.61.30.3-0.6
Pavlov. Cond. magazine entry number0.00.00.3-0.1-0.1-0.1-0.1-0.1-0.30.10.10.10.10.3-0.5-0.2
Pavlov. Cond. intertrial magazine entries0.51.22.0-1.41.2-1.01.01.30.60.80.7-1.11.2-0.3-1.4-1.4
Pavlov. Cond. lever-magazine prob. diff.0.10.20.40.5-0.20.2-0.5-0.10.0-0.4-0.4-0.50.40.60.4-0.6
Pavlov. Cond. response bias0.20.20.60.3-0.20.4-0.30.20.50.1-0.6-0.70.80.6-0.0-0.7
Time in closed arm before self-admin0.10.20.50.10.4-0.60.10.1-0.6-0.40.6-0.1-0.30.20.7-0.3
Time in closed arm after self-admin0.10.10.40.10.1-0.20.0-0.2-0.5-0.40.40.6-0.5-0.20.60.5
Time in open arm before self-admin0.70.82.2-0.70.5-0.20.20.60.70.7-0.1-1.51.30.4-1.4-1.4
Time in open arm after self-admin0.20.30.80.3-0.20.1-0.7-0.4-0.1-0.4-0.2-0.80.60.7-0.4-0.9
Bone: periosteal estimation1.02.56.3-0.11.1-2.5-0.2-0.9-2.3-2.32.50.4-1.7-1.01.6-0.2
Bone: periosteal perimeter0.61.24.0-1.01.5-2.00.70.2-0.7-0.82.0-0.8-0.4-1.10.3-0.5
Bone: post-yield work0.91.54.1-0.91.5-1.81.30.3-0.6-0.82.00.2-1.3-1.91.10.7
Progressive ratio test 1 active lever presses0.00.00.20.30.00.1-0.1-0.2-0.10.1-0.0-0.5-0.1-0.10.10.3
Progressive ratio test 1 breakpoint0.00.00.20.20.10.1-0.1-0.2-0.20.00.0-0.5-0.1-0.20.20.2
Progressive ratio test 1 inactive lever presses0.20.51.60.7-0.81.0-0.1-0.50.20.3-0.81.1-0.3-0.40.51.3
Progressive ratio test 2 active lever presses0.30.51.4-0.0-0.30.90.00.31.01.2-0.9-0.31.00.2-1.0-0.3
Progressive ratio test 2 breakpoint0.50.61.50.1-0.41.0-0.10.21.01.2-1.1-0.41.10.4-1.1-0.4
Progressive ratio test 2 inactive lever presses0.10.31.1-0.70.9-0.40.60.40.10.30.7-1.10.1-0.8-0.10.1
Incentive Sensitization - Responses0.30.82.2-0.60.10.50.30.71.21.3-0.7-0.61.50.1-1.5-1.1
Incentive Sensitization - Breakpoint0.40.82.1-0.4-0.10.70.30.71.31.4-0.9-0.41.40.2-1.4-1.0
Sum of active levers in priming session hrs 5-60.20.21.2-0.40.5-0.5-0.10.2-0.2-0.30.4-1.10.1-0.1-0.0-0.6
Progressive ratio1.44.27.32.6-2.20.5-2.5-2.7-2.5-2.3-0.52.6-2.11.12.10.7
Food seeking constrained by brief footshock0.20.20.70.7-0.60.4-0.8-0.4-0.2-0.4-0.6-0.10.10.6-0.0-0.2
Seeking ratio, punishment vs. effort1.22.76.2-2.11.7-0.61.72.21.81.60.4-2.51.9-0.5-1.8-1.2
Retroperitoneal fat weight0.20.83.00.4-0.61.10.1-0.6-0.30.2-0.51.4-0.8-0.81.31.7
Reaction time number correct0.72.34.02.0-2.01.4-1.9-1.9-1.2-1.2-1.11.8-1.21.41.01.2
Reaction time mean minus median0.32.03.6-1.91.8-0.91.91.91.41.20.9-1.71.0-1.0-1.1-0.9
Reaction time mean minus median AUC0.32.04.0-1.81.8-0.71.91.91.51.30.7-2.01.1-1.1-1.0-0.5
Reaction time num false alarms0.40.71.3-1.00.9-1.00.61.00.40.30.6-0.70.7-0.6-1.1-1.2
Reaction time num false alarms AUC0.40.82.7-1.01.0-1.30.40.90.20.10.8-0.80.9-0.3-1.1-1.7
Reaction time trials correct on left0.72.34.02.0-2.01.4-1.9-1.9-1.2-1.2-1.11.8-1.21.41.01.2
Reaction time trials on left0.72.33.92.0-1.91.4-1.8-1.9-1.3-1.2-1.11.8-1.21.41.11.2
Reaction time mean1.43.17.5-2.42.5-1.52.72.21.31.21.7-1.50.3-2.3-0.20.4
Reaction time mean AUC1.22.86.8-2.32.3-1.32.62.21.31.21.6-1.60.4-2.1-0.20.3
Median of all reaction times1.52.45.8-2.02.1-1.32.41.80.91.01.6-1.1-0.1-2.20.10.8
Reaction time omissions1.11.84.0-2.01.8-1.32.01.71.10.91.3-0.80.3-1.8-0.20.1
Reaction time false alarm rate2.02.85.2-2.02.1-2.11.41.90.80.61.4-1.91.4-1.0-1.6-2.3
Reaction time premature initiation rate0.50.71.80.7-0.1-0.6-0.3-0.9-1.2-1.20.60.7-1.2-0.41.30.9
Reaction time premature initiations0.82.43.91.8-1.30.2-1.4-2.0-1.9-1.9-0.01.7-1.90.51.91.5
Std. dev. reaction times0.82.85.8-2.22.4-1.62.02.11.00.81.6-2.31.0-1.4-0.8-1.2
Reaction time trials completed0.72.33.92.0-1.91.4-1.8-1.9-1.3-1.2-1.11.8-1.21.41.11.2
Reaction time trials AUC0.62.13.51.8-1.91.4-1.7-1.8-1.2-1.1-1.11.8-1.21.21.01.3
Run reversals in cocaine runway, females0.40.50.90.8-0.90.9-0.7-0.8-0.4-0.2-0.70.9-0.50.50.60.8
Run reversals in cocaine runway, males0.40.40.9-0.91.0-0.70.80.80.30.30.8-0.70.2-0.7-0.3-0.3
Latency to leave start box in cocaine runway1.01.43.3-1.81.5-1.11.71.50.71.01.1-0.90.4-1.5-0.40.1
Latency to leave start box in cocaine runway, F0.81.02.7-1.61.2-0.71.41.30.81.10.7-0.70.5-1.1-0.60.2
Latency to leave start box in cocaine runway, M0.30.31.0-0.80.7-0.70.80.60.10.10.7-0.2-0.2-1.00.20.1
Std. dev. time between licks in bursts1.63.18.9-2.02.6-3.01.71.4-0.3-0.32.7-1.5-0.1-2.1-0.1-1.0
Total sessions with >9 infusions0.30.30.90.7-0.50.4-0.9-0.5-0.2-0.2-0.5-0.80.30.9-0.5-0.4
Short access day 1 total inactive lever presses0.30.71.8-1.31.1-1.00.40.3-0.4-0.51.2-1.3-0.4-1.0-0.10.4
Short access day 10 total inactive lever presses0.10.81.7-1.20.7-0.11.31.11.11.10.20.20.6-1.3-0.50.3
Short access day 1 total infusions0.10.22.00.30.3-0.1-0.10.1-0.0-0.10.1-1.40.20.1-0.30.0
Short access day 10 total infusions0.10.20.80.3-0.50.9-0.4-0.20.40.4-0.9-0.40.50.4-0.30.2
Short access total infusions0.10.20.90.2-0.20.5-0.4-0.30.00.0-0.4-0.90.20.3-0.40.3
Short access day 1 locomotion0.50.91.9-0.80.70.11.11.21.41.2-0.1-0.61.1-0.5-1.3-0.5
Short access day 10 total locomotion0.31.33.00.90.6-1.5-0.3-0.7-1.7-1.71.60.4-1.4-0.71.6-0.4
Short access total locomotion0.20.30.90.10.6-0.70.3-0.0-0.5-0.50.9-0.1-0.8-0.60.50.2
One hour access (0.3 mA shock)1.72.05.8-1.00.50.51.21.62.22.4-0.8-0.82.0-0.2-1.9-1.2
Compulsive drug intake2.73.99.7-2.62.3-1.53.12.71.81.91.5-0.30.9-2.7-1.4-0.8
One hour access (shock baseline)0.51.33.51.3-1.41.8-1.3-0.80.40.5-1.9-0.20.71.7-0.4-0.1
Social response proportion0.70.92.3-0.40.7-1.3-0.1-0.6-1.4-1.41.5-0.3-1.0-0.60.80.4
Social responses0.40.51.6-0.30.4-1.1-0.5-0.7-1.2-1.31.0-0.4-0.4-0.10.3-0.6
Social time1.93.06.8-2.62.3-2.12.32.10.80.61.9-1.00.6-2.2-0.7-0.9
Soleus weight2.26.520.3-2.63.6-4.52.71.5-0.7-0.84.4-1.0-1.4-3.30.90.2
Bone: stiffness0.40.72.81.0-1.00.7-0.5-0.9-0.4-0.5-0.51.7-0.9-0.10.91.1
Tibialis anterior weight0.20.82.10.8-1.31.4-0.9-0.9-0.1-0.3-1.21.3-0.10.60.60.3
Time to tail flick, vehicle, before self-admin0.81.02.8-1.10.10.41.31.41.71.6-0.60.60.8-0.0-1.0-0.1
Time to tail flick, vehicle, after self-admin0.30.61.3-1.01.0-0.70.91.10.60.80.5-1.00.8-0.3-0.6-0.6
Time to tail flick, test, before self-admin0.50.61.40.5-0.60.7-0.50.10.70.6-1.00.11.21.0-1.0-1.1
Time to tail flick, test, after self-admin1.31.43.7-0.50.10.80.31.01.61.6-1.1-0.81.90.6-1.9-1.2
Delta time to tail flick, vehicle, before/after SA0.30.32.0-0.00.10.3-0.30.00.30.4-0.3-1.40.70.4-0.5-0.1
Delta time to tail flick, test, before/after SA0.20.30.7-0.4-0.00.70.50.30.80.8-0.50.30.1-0.4-0.20.8
Tibia length1.64.49.8-0.11.3-2.80.1-1.3-3.1-3.03.11.2-2.5-1.82.60.7
Ambulatory time before self-admin0.00.10.7-0.30.2-0.10.50.20.10.20.20.4-0.3-0.80.0-0.1
Ambulatory time after self-admin0.40.72.30.4-0.2-0.7-0.9-0.9-1.5-1.50.70.5-0.7-0.00.8-0.8
Bone: tissue strength0.40.41.20.5-0.20.2-0.2-0.6-0.6-0.70.20.5-0.9-0.20.91.1
Total heroin consumption0.10.10.3-0.30.4-0.50.20.3-0.10.10.4-0.20.1-0.3-0.3-0.5
Bone: trabecular number1.12.05.8-0.1-0.82.30.70.82.42.4-2.10.41.00.1-1.40.7
Bone: trabecular spacing1.31.95.90.40.6-2.0-0.7-1.0-2.4-2.31.90.0-1.40.01.5-0.1
Bone: trabecular thickness0.81.13.70.2-0.81.90.50.41.51.6-1.50.70.5-0.1-0.71.0
Bone: trabecular tissue density0.30.51.80.7-0.2-0.3-1.0-0.3-0.6-0.2-0.1-0.50.41.2-0.6-1.3
Water consumed over 24 hours0.20.30.7-0.70.8-0.80.60.50.0-0.20.8-0.60.1-0.70.0-0.4
Number of responses in last shaping day1.11.54.5-0.31.5-2.10.20.3-1.3-1.42.1-1.5-0.4-0.80.0-1.1