Hub : Genes

Vars1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Vars1 0.15 0.06 4.9e-14 0.09 0.14 0.15 0.14 1.1e-09 7.8e-15 2.7e-16 3.9e-15
2 NAcc mRNA stability Vars1 0.07 0.04 1.7e-10 0.03 0.06 0.06 0.06 9.9e-06 6.4e-10 3.8e-09 2.4e-09
3 pVTA mRNA stability Vars1 0.09 0.05 1.5e-06 0.09 0.08 0.08 0.08 1.2e-07 4.7e-07 2.8e-07 2.8e-07
4 Brain mRNA stability Vars1 0.12 0.06 3.7e-11 0.12 0.13 0.12 0.12 7.6e-11 7.7e-12 1.1e-11 1.7e-11
5 BLA gene expression Vars1 0.11 0.1 3.0e-03 0.05 0.03 0.02 0.04 1.3e-03 1.5e-02 2.4e-02 4.1e-03
6 PL gene expression Vars1 0.05 0.03 1.3e-06 0.06 0.05 0.04 0.05 8.0e-07 1.6e-06 3.0e-05 3.3e-06
7 NAcc gene expression Vars1 0.04 0.03 5.7e-07 0.05 0.04 0.04 0.04 7.7e-08 1.5e-06 4.9e-06 1.4e-06
8 Adipose gene expression Vars1 0.09 0.05 2.9e-05 0.03 0.04 0.03 0.03 3.8e-04 2.6e-05 3.3e-04 2.0e-04
9 PL mRNA stability Vars1 0.03 0.02 6.4e-03 0.01 0.01 0 0 4.3e-02 4.6e-02 2.5e-01 1.3e-01
10 pVTA gene expression Vars1 0.08 0.04 3.2e-05 0.06 0.06 0.06 0.06 8.1e-06 8.8e-06 3.2e-05 2.2e-05
11 IC mRNA stability Vars1 0.07 0.05 4.3e-03 0.06 0.06 0.05 0.04 1.8e-03 2.4e-03 3.6e-03 5.5e-03
12 Brain gene expression Vars1 0.27 0.12 3.9e-16 0.13 0.12 0.11 0.13 6.4e-12 2.6e-11 1.3e-10 5.5e-12
13 Liver gene expression Vars1 0.08 0.04 1.2e-06 0.05 0.05 0.06 0.05 2.3e-06 1.5e-06 3.7e-07 2.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.43.80.1-0.7-1.90.6-0.7-2.0-1.9-1.7-0.4-0.9-0.1-1.2-0.5
Area under the delay curve0.20.21.30.10.20.6-0.3-0.00.50.50.31.1-0.3-0.3-0.10.1
BMI with tail1.34.512.0-2.3-2.0-1.3-1.32.41.81.8-0.7-3.52.50.22.9-2.4
BMI without tail1.95.812.2-3.1-2.3-0.8-2.93.53.02.8-0.4-2.82.4-1.32.6-0.8
Body weight2.08.919.5-2.6-1.20.8-2.03.54.34.01.6-3.44.40.64.1-2.5
Weight adjusted by age2.23.48.0-1.50.01.2-1.01.82.72.61.7-0.82.70.42.8-1.7
Bone surface0.10.10.30.30.30.40.5-0.2-0.0-0.10.4-0.40.30.60.2-0.1
Bone volume0.10.20.8-0.3-0.5-0.70.00.2-0.3-0.3-0.5-0.90.20.10.1-0.4
Breakpoint value in progressive ratio session0.30.41.00.90.50.20.4-0.6-0.5-0.70.10.7-0.80.4-1.00.7
Number of licking bursts1.11.73.31.81.81.81.5-1.5-0.6-0.41.41.2-0.71.3-1.10.9
Context. condit. distance diff. score4.25.111.13.23.01.63.3-2.9-1.9-2.01.71.9-1.22.7-1.40.3
Locomotion velocity, session 10.80.82.80.91.10.70.6-0.9-0.5-0.50.61.7-1.00.1-0.81.3
Locomotion distance, session 10.60.82.60.6-0.0-1.00.7-0.8-1.5-1.6-0.90.3-1.10.0-1.0-0.0
Locomotion velocity, session 20.70.81.51.11.00.50.9-1.1-0.9-0.90.41.2-1.10.6-0.70.9
Locomotion distance, session 21.01.33.31.40.8-0.31.6-1.3-1.7-1.8-0.10.7-1.01.2-0.6-0.6
Locomotion velocity, session 30.50.62.2-0.7-0.9-0.8-1.10.70.50.2-0.9-0.1-0.5-1.50.10.8
Locomotion distance, session 31.11.23.11.00.3-0.80.8-1.2-1.5-1.7-0.91.0-1.7-0.4-1.20.8
Stereotopy head waving bouts, day 30.70.82.70.40.81.70.00.11.31.21.50.20.70.60.70.3
Stereotopy head waving duration, day 30.80.93.1-0.30.31.3-0.90.71.81.71.20.10.9-0.10.70.5
Locomotion velocity, session 73.03.38.32.11.0-0.92.4-2.2-2.9-2.9-0.71.3-1.71.4-1.4-0.7
Locomotion distance, session 73.24.111.41.80.9-1.12.0-2.6-3.2-3.4-1.21.8-2.50.4-1.90.3
Stereotopy head waving bouts, day 70.70.83.8-0.6-0.10.4-1.10.20.70.7-0.10.9-0.8-1.4-0.51.9
Stereotopy head waving duration, day 70.50.61.7-0.7-0.30.4-1.10.51.01.00.00.3-0.2-1.2-0.31.3
Locomotion velocity, session 83.64.39.72.93.12.82.4-2.1-0.6-0.42.72.2-0.82.1-0.71.2
Locomotion distance, session 84.46.315.83.63.01.14.0-3.3-2.7-2.81.41.7-1.33.2-1.2-0.5
Degree of sensitization distance0.70.71.70.91.21.11.1-0.9-0.4-0.31.10.60.01.30.1-0.0
Degree of sensitization stereotypy0.80.83.8-0.3-0.1-0.1-0.7-0.2-0.1-0.1-0.51.0-1.3-1.4-1.22.0
Conditioned locomotion0.60.71.6-0.00.40.80.40.30.90.81.1-0.91.31.11.1-1.1
Cocaine response after cond. corrected0.91.13.21.30.70.11.8-1.1-1.1-0.90.4-0.60.31.80.3-1.5
Cocaine response after cond. not corrected0.60.82.01.01.01.21.1-0.60.10.31.3-0.20.61.40.5-0.5
Cocaine response before conditioning1.92.36.9-1.10.11.7-1.81.62.62.51.40.30.8-0.90.61.6
Saline control response4.15.411.9-3.4-2.9-1.5-3.42.92.32.2-1.6-2.11.4-2.61.6-0.3
Bone: connectivity density0.60.92.70.4-0.2-1.21.1-0.8-1.6-1.5-0.9-0.6-0.20.8-0.4-1.1
Bone: cortical apparent density1.31.83.9-1.7-1.9-1.5-1.31.40.80.4-1.3-2.01.0-1.01.0-1.3
Bone: cortical area0.10.10.30.10.20.40.00.30.40.50.5-0.20.10.20.30.2
Bone: cortical porosity1.41.55.8-0.5-0.00.4-1.40.40.60.8-0.21.9-1.4-2.0-1.02.4
Bone: cortical porosity1.21.35.0-0.10.51.0-0.90.10.60.70.42.1-1.1-1.4-0.92.2
Bone: cortical thickness0.81.33.0-1.3-1.7-1.7-1.21.20.10.3-1.6-1.3-0.1-1.30.3-0.3
Bone: cortical thickness1.61.94.4-1.8-2.1-1.9-1.51.60.30.3-1.8-1.80.4-1.30.6-0.6
Bone: cortical tissue density1.21.73.5-1.6-1.8-1.4-1.31.30.80.5-1.2-1.91.0-1.01.0-1.3
Condit. Reinf. active minus inactive responses0.80.93.10.30.2-0.3-0.1-0.4-0.8-0.8-0.51.8-1.8-0.7-1.21.3
Condit. Reinf. active-inactive response ratio0.50.51.4-0.8-0.8-0.6-1.10.70.20.2-0.80.4-0.7-1.2-0.20.7
Condit. Reinf. active responses0.60.82.50.40.1-0.80.3-0.5-1.1-1.2-0.81.3-1.6-0.3-1.00.5
Condit. Reinf. inactive responses1.11.33.90.6-0.3-1.60.7-0.8-1.9-2.0-1.50.4-1.2-0.1-1.3-0.3
Incentive salience index mean2.02.45.21.91.70.61.8-1.8-1.7-1.70.52.3-1.80.9-1.40.9
Condit. Reinf. lever presses3.65.111.93.22.71.33.4-2.8-2.2-2.41.51.8-1.22.7-1.4-0.2
Condit. Reinf. active minus inactive responses0.50.72.4-0.5-0.10.6-1.11.11.51.50.60.10.5-0.50.60.7
Condit. Reinf. active-inactive response ratio0.81.03.2-0.10.51.3-0.70.81.71.81.40.30.80.10.80.6
Condit. Reinf. active responses0.20.30.8-0.5-0.30.1-0.90.70.80.80.1-0.10.1-0.80.20.7
Condit. Reinf. inactive responses0.30.40.9-0.7-0.9-0.9-0.60.5-0.1-0.2-1.0-0.6-0.2-0.9-0.10.0
Condit. Reinf. lever presses0.20.31.4-0.3-0.1-0.2-0.50.0-0.00.2-0.40.7-0.8-0.9-0.21.2
Condit. Reinf. lever reinforcers received0.20.31.0-0.3-0.10.2-0.80.50.70.70.10.2-0.2-0.80.01.0
Conditioned reinforcement - actives0.10.20.4-0.5-0.6-0.7-0.50.60.2-0.1-0.5-0.30.2-0.20.3-0.2
Conditioned reinforcement - inactives0.20.20.7-0.5-0.5-0.5-0.80.80.50.4-0.40.20.2-0.10.2-0.4
Conditioned locomotion0.00.10.3-0.00.10.0-0.00.30.30.20.20.20.50.00.3-0.4
Patch foraging indifference point 0 sec1.73.26.5-2.5-2.2-1.6-2.52.61.51.6-1.2-1.41.2-1.91.3-0.6
Patch foraging indifference point AUC0.20.31.6-0.30.10.5-0.50.00.40.50.10.6-0.5-0.8-0.41.3
Delay disc. indifference point, 0s delay0.60.71.71.21.11.00.9-0.8-0.1-0.11.01.00.01.3-0.1-0.3
Delay disc. indifference point, 16s delay0.40.41.6-0.9-0.8-0.6-0.90.50.20.3-0.80.3-0.3-1.30.1-0.1
Delay disc. indifference point, 2s delay0.80.92.51.11.01.5-0.20.01.11.01.41.60.10.10.10.4
Delay disc. indifference point, 24s delay0.60.71.5-1.0-0.40.2-1.20.71.11.2-0.00.90.0-1.20.70.4
Delay disc. indifference point, 4s delay0.50.51.7-0.20.00.9-0.80.61.31.30.70.50.3-0.20.30.4
Delay disc. indifference point, 8s delay0.20.21.50.20.20.20.1-0.4-0.1-0.20.01.2-0.5-0.1-0.70.0
Indifference point function ln k0.50.92.01.41.20.80.8-1.0-0.5-0.60.81.4-0.90.5-1.00.9
Indifference point function log k0.50.92.01.41.20.80.8-1.0-0.5-0.60.81.4-0.90.5-1.00.9
Patch foraging total patch changes 0 sec1.83.46.9-2.6-2.3-1.7-2.62.61.51.6-1.3-1.41.2-1.91.3-0.6
Patch foraging total patch changes 12 sec1.72.24.9-2.2-1.8-1.0-2.11.81.21.5-1.1-1.20.7-1.81.10.1
Patch foraging total patch changes 18 sec2.13.37.4-2.3-2.7-2.6-1.92.00.20.3-2.3-2.20.7-1.70.7-1.2
Patch foraging total patch changes 24 sec1.11.95.2-1.8-2.0-2.2-1.20.9-0.6-0.3-2.3-1.0-0.2-1.6-0.1-0.7
Patch foraging total patch changes 6 sec2.03.07.4-2.7-2.2-1.5-2.32.21.21.5-1.4-1.30.9-2.01.4-0.6
Patch foraging time to switch 0 sec0.81.66.2-0.7-1.0-1.00.10.90.00.0-0.6-2.31.60.71.7-2.5
Patch foraging water rate 0 sec0.10.10.4-0.4-0.10.1-0.40.40.60.60.30.10.5-0.10.3-0.3
Patch foraging water rate 12 sec0.30.51.5-0.5-0.9-1.2-0.40.1-0.7-0.8-1.2-0.5-0.5-0.7-0.8-0.1
Patch foraging water rate 18 sec0.20.30.8-0.9-0.6-0.2-0.70.50.70.7-0.3-0.50.5-0.50.6-0.4
Patch foraging water rate 24 sec0.20.20.6-0.5-0.8-0.7-0.60.40.10.1-0.6-0.70.1-0.6-0.1-0.1
Patch foraging water rate 6 sec0.10.20.6-0.1-0.6-0.6-0.30.1-0.3-0.4-0.6-0.3-0.1-0.3-0.8-0.3
Seeking ratio, delayed vs. immediate footshock0.70.82.5-0.5-0.90.1-1.50.80.90.7-0.4-0.5-0.3-1.5-0.41.6
Distance traveled before self-admin0.50.62.40.30.40.50.9-0.20.30.20.8-1.01.21.60.9-0.5
Distance traveled after self-admin0.70.92.4-0.6-0.20.7-0.70.91.61.60.7-1.11.10.21.20.5
Extensor digitorum longus weight0.20.72.10.71.11.20.8-0.20.30.71.4-0.10.81.40.6-0.4
Bone: elastic displacement0.50.61.7-0.8-0.9-1.0-1.10.50.00.1-1.10.4-0.6-1.3-0.60.4
Bone: elastic work0.10.20.5-0.5-0.4-0.3-0.70.60.50.6-0.20.10.2-0.50.2-0.2
Bone: endosteal estimation2.24.814.10.41.93.80.10.73.02.93.7-0.12.31.72.00.2
Bone: endosteal perimeter1.63.410.61.82.63.31.6-0.71.01.03.20.90.92.50.70.3
Epididymis fat weight4.816.333.4-4.9-5.8-5.4-3.94.51.51.1-4.6-5.62.4-2.12.5-4.2
Delta time in closed arm before/after self-admin0.70.71.7-0.30.10.40.00.60.80.90.8-0.71.31.01.2-1.1
Delta time in open arm before/after self-admin0.30.30.8-0.7-0.8-0.6-0.90.60.30.3-0.7-0.2-0.2-0.70.10.1
Diff in mean of infusions in LGA sessions2.12.56.92.31.0-0.32.1-2.0-2.4-2.6-0.30.4-1.41.0-1.6-0.2
Delay discount exponential model param0.20.31.4-0.0-0.2-0.60.5-0.1-0.6-0.6-0.4-1.20.30.50.1-0.3
Extinction: sum of active levers before priming0.70.81.81.31.31.01.2-1.1-0.5-0.31.01.0-0.31.0-0.30.3
Active lever presses in extinction session 60.20.20.5-0.4-0.5-0.7-0.50.4-0.0-0.0-0.60.3-0.1-0.2-0.0-0.7
Bone: final force1.32.25.2-1.6-1.3-0.5-1.11.71.51.6-0.2-2.31.80.11.9-1.6
Bone: final moment1.21.94.0-1.5-1.2-0.5-1.11.71.51.6-0.1-2.01.70.01.8-1.4
Food consumed during 24 hour testing period0.81.12.80.60.71.00.9-0.00.70.71.4-0.71.31.71.4-1.2
Glucose3.55.613.62.93.73.62.6-2.1-0.00.03.52.6-0.22.5-0.21.1
Heart weight1.32.06.2-1.0-0.11.3-1.51.62.52.41.20.11.4-0.71.30.4
Delay discount hyperbolic model param0.30.41.7-0.1-0.2-0.70.6-0.1-0.7-0.7-0.4-1.30.40.50.2-0.5
Intermittent access intake day 1-15 change0.10.21.0-0.5-0.3-0.4-0.30.1-0.2-0.3-0.5-0.2-0.5-0.7-0.41.0
Intermittent access intake escalation0.50.92.4-1.2-1.2-1.0-1.20.7-0.1-0.1-1.4-0.4-0.8-1.6-0.51.1
Intermittent access intake escalation 20.20.31.4-0.20.10.1-0.1-0.2-0.3-0.3-0.20.5-0.8-0.5-0.61.2
Intermitt. access day 1 inactive lever presses0.51.85.31.51.81.91.5-1.00.30.32.10.30.62.30.6-0.3
Intermitt. access day 15 inactive lever presses0.20.41.1-0.60.00.5-0.30.61.01.00.6-0.40.90.21.1-0.4
Intermitt. access escalation Index1.62.35.32.31.30.22.0-2.0-1.9-1.90.30.9-1.31.2-1.90.4
Intermittent access day 1 total infusions0.30.51.60.10.1-0.80.2-0.4-1.0-1.1-0.71.3-1.0-0.1-0.9-0.1
Intermittent access day 15 total infusions0.60.82.1-0.8-0.9-1.3-0.80.3-0.6-0.6-1.40.4-1.0-1.4-0.80.6
Intermittent access terminal intake (last 3 days)0.40.61.8-1.0-0.8-0.6-1.10.70.10.0-1.00.5-0.6-1.3-0.40.6
Intermittent access total infusions0.40.41.1-0.6-0.6-0.9-0.80.4-0.2-0.3-1.00.6-0.6-1.1-0.60.2
Intermittent access day 1 locomotion0.20.20.7-0.8-0.5-0.9-0.10.3-0.3-0.4-0.7-0.40.2-0.20.0-0.7
Intermittent access day 15 total locomotion0.30.62.1-1.4-0.7-0.4-0.70.90.70.6-0.2-0.90.9-0.40.9-0.4
Intermittent access total locomotion0.50.51.4-1.2-1.0-0.9-0.90.90.40.2-0.8-0.60.4-0.80.4-0.4
Intermittent access standard deviation1.32.66.2-2.5-1.7-0.8-2.02.11.81.6-0.6-1.71.4-1.01.7-1.1
Left kidney weight1.98.817.6-3.2-2.2-0.2-2.93.84.23.90.4-3.43.8-0.83.6-1.9
Right kidney weight1.88.116.7-2.8-1.90.1-2.33.53.93.60.7-3.54.1-0.23.6-2.4
Cocaine induced anxiety0.30.41.20.80.80.71.1-0.8-0.3-0.30.80.0-0.01.10.2-0.1
Post-drug Anxiety0.20.20.40.20.30.60.20.10.50.40.6-0.40.40.60.3-0.2
Baseline Anxiety0.10.10.3-0.2-0.30.1-0.50.50.60.50.1-0.20.4-0.5-0.30.0
Tail length1.14.413.8-0.80.92.9-1.51.83.73.42.90.22.1-0.11.71.1
Length with tail1.66.819.2-0.71.03.2-1.12.14.44.13.6-0.63.41.03.0-0.5
Length without tail2.37.418.3-0.60.62.10.11.83.63.43.0-2.34.32.53.9-3.0
Times rat made contact with spout1.92.15.5-0.8-1.4-2.1-1.20.2-1.1-0.9-2.40.5-1.8-2.2-1.41.3
Lifetime Intake0.30.30.7-0.5-0.6-0.7-0.80.5-0.0-0.1-0.80.6-0.4-0.9-0.40.0
Liver weight, left1.42.37.00.61.62.40.90.01.61.52.7-0.31.61.91.6-0.1
Liver weight, right1.72.98.51.02.12.81.0-0.21.61.62.90.71.32.31.60.1
Locomotor activity0.61.02.90.00.31.4-0.90.71.71.71.00.30.4-0.20.31.4
Locomotor testing distance0.30.61.60.30.51.1-0.20.51.31.11.10.10.60.50.50.6
Locomotor testing rearing0.50.92.0-0.20.20.9-0.20.81.41.21.1-0.71.41.11.3-0.6
Locomotion in novel chamber0.00.00.1-0.1-0.3-0.1-0.30.2-0.00.2-0.2-0.3-0.2-0.1-0.20.0
Locomotion in novel chamber post-restriction0.71.22.4-1.0-1.0-0.4-1.11.61.31.2-0.0-1.41.5-0.21.3-1.0
Fecal boli incidents, locomotor time 10.20.31.90.3-0.2-0.5-0.00.50.0-0.0-0.0-0.50.70.60.3-1.4
Change in fecal boli incidents, locomotor task0.90.93.20.61.21.80.8-0.70.60.51.70.50.60.90.60.4
Time >=10cm from walls, locomotor time 12.22.35.10.20.61.50.50.41.61.81.9-1.42.32.02.0-1.6
Bouts of movement, locomotor time 10.50.51.50.40.3-0.10.7-1.0-1.2-0.9-0.30.5-1.20.1-0.80.8
Total resting periods, locomotor time 10.30.40.90.50.50.10.7-0.9-1.0-0.7-0.10.5-0.90.1-0.50.6
Rest time, locomotor task time 10.20.20.50.60.60.60.00.10.40.60.70.50.10.30.20.3
Distance moved, locomotor task time 10.10.20.4-0.6-0.5-0.1-0.30.40.40.2-0.2-0.60.4-0.50.2-0.3
Vertical activity count, locomotor time 10.20.51.4-0.9-1.0-0.6-0.70.80.30.2-0.5-1.20.7-0.50.2-1.0
Time >=10cm from walls, locomotor time 21.11.64.10.30.71.50.20.61.71.51.9-0.32.00.91.3-1.2
Bouts of movement, locomotor time 20.20.31.4-0.00.00.3-0.6-0.00.20.40.00.6-0.9-0.7-0.41.2
Total resting periods, locomotor time 20.30.52.40.40.50.7-0.3-0.40.10.40.41.1-1.1-0.5-0.71.6
Rest time, locomotor task time 21.21.54.01.41.71.41.8-1.4-0.4-0.21.60.40.22.00.2-0.3
Distance moved, locomotor task time 21.01.12.1-1.4-1.2-0.9-0.91.30.70.6-0.7-1.11.3-1.00.9-1.4
Vertical activity count, locomotor time 20.60.81.9-1.0-0.9-0.4-0.81.10.80.6-0.2-0.81.3-0.51.1-1.4
Light reinforcement 10.20.62.7-0.0-0.4-0.40.40.3-0.0-0.1-0.1-1.71.20.50.6-1.3
Light reinforcement 20.40.71.70.20.40.40.80.00.40.40.8-0.91.11.21.2-1.3
Bone: marrow area2.24.913.60.21.73.7-0.00.93.13.13.7-0.22.51.72.20.1
Bone: maximum diameter1.22.25.41.92.32.31.6-1.10.00.12.31.3-0.21.7-0.20.8
Bone: maximum force0.81.53.0-1.2-0.8-0.1-0.71.41.31.50.2-1.71.60.21.7-1.4
Bone: maximum moment0.71.32.6-1.1-0.6-0.0-0.71.41.31.60.3-1.41.50.21.6-1.2
Mean time between licks in bursts1.02.55.52.12.32.01.8-1.7-0.6-0.71.91.6-0.61.7-1.01.1
Mean num. licks in bursts1.92.97.5-2.1-2.4-2.7-2.11.60.20.1-2.5-0.9-0.2-2.40.4-0.1
Cd content in liver0.80.85.2-0.4-0.7-1.20.20.3-0.1-0.4-0.6-1.00.90.70.7-2.3
Co content in liver1.41.63.3-1.6-1.3-0.8-1.11.61.20.9-0.4-1.51.5-0.21.8-1.7
Cu content in liver1.51.85.0-0.3-1.2-2.1-0.7-0.1-1.1-1.3-2.20.2-1.9-1.6-1.21.1
Fe content in liver1.01.22.4-1.4-1.4-1.2-1.11.20.60.5-0.9-1.51.1-0.40.7-1.2
K content in liver0.60.61.60.80.5-0.21.0-1.1-1.2-1.2-0.20.3-0.70.5-0.50.3
Mg content in liver2.72.75.62.42.21.62.3-2.0-1.2-1.41.41.4-1.01.7-0.71.1
Mn content in liver3.23.57.52.62.72.52.6-1.8-0.7-0.72.51.4-0.02.5-0.30.1
Na content in liver0.60.71.5-0.0-0.5-0.7-0.4-0.4-0.6-0.8-1.10.2-1.2-1.1-1.21.2
Rb content in liver0.30.41.30.40.4-0.01.0-0.6-0.4-0.70.2-0.40.41.10.7-0.7
Se content in liver3.23.87.92.42.62.41.6-1.8-0.4-0.51.82.8-2.10.8-1.32.6
Sr content in liver0.50.51.2-0.40.20.8-0.10.50.60.70.80.01.00.51.0-1.1
Zn content in liver0.30.30.80.60.70.60.7-0.30.0-0.20.80.30.30.90.7-0.3
Bone: minimum diameter1.32.37.11.52.12.51.3-0.40.90.92.70.41.02.20.8-0.1
Time in familiar zone, hab. session 12.22.16.8-0.8-1.6-2.4-1.00.2-1.4-1.3-2.60.1-1.4-1.9-1.00.6
Time in novel zone, hab. session 11.61.64.70.21.12.00.30.41.61.62.2-0.31.51.11.1-0.4
Total zone transitions, hab. session 10.30.51.20.80.5-0.00.8-0.8-1.0-1.1-0.00.3-0.70.5-0.60.5
Total locomotion distance, hab. session 10.40.51.60.80.5-0.21.0-0.8-1.2-1.3-0.10.1-0.50.9-0.40.0
Locomotion velocity, hab. session 10.20.31.00.60.4-0.10.7-0.6-0.9-1.0-0.00.1-0.50.6-0.30.3
Time in familiar zone, hab. session 20.70.71.9-0.9-1.3-1.2-0.80.5-0.2-0.3-1.4-0.9-0.4-0.90.20.4
Time in novel zone, hab. session 20.20.20.6-0.20.30.6-0.30.40.70.80.60.40.6-0.10.1-0.3
Total zone transitions, hab. session 20.30.30.80.60.1-0.30.8-0.5-0.8-0.9-0.1-0.70.10.9-0.1-0.5
Total locomotion distance, hab. session 20.91.23.31.20.4-0.51.6-1.2-1.8-1.8-0.3-0.4-0.41.5-0.6-0.7
Locomotion velocity, hab. session 21.31.74.21.60.8-0.31.9-1.6-2.0-2.1-0.1-0.0-0.71.6-0.9-0.4
Novel to familiar place preference ratio0.10.10.5-0.00.1-0.0-0.0-0.4-0.3-0.5-0.20.6-0.5-0.3-0.70.4
Novelty place preference0.10.10.5-0.10.20.2-0.2-0.3-0.2-0.3-0.10.7-0.4-0.4-0.60.6
Time in novel zone, NPP test0.10.10.5-0.20.10.2-0.3-0.10.0-0.1-0.00.7-0.3-0.4-0.50.7
Total zone transitions, NPP test0.81.23.01.30.8-0.21.6-1.4-1.7-1.7-0.10.4-0.71.0-0.7-0.2
Total locomotion distance, NPP test0.91.33.41.10.6-0.61.7-1.2-1.6-1.8-0.2-0.0-0.11.5-0.3-1.4
Locomotion velocity, NPP test1.42.05.51.50.7-0.72.1-1.6-2.1-2.3-0.30.1-0.41.7-0.6-1.4
Intraocular pressure0.50.72.4-0.8-1.1-1.6-0.20.2-0.7-0.7-1.3-0.90.2-0.70.1-0.7
Delta distance traveled before/after self-admin1.31.33.7-1.1-0.70.4-1.91.41.71.80.10.30.1-1.50.41.2
Delta ambulatory time before/after self-admin0.70.92.3-0.7-0.30.6-1.51.01.51.50.40.40.0-1.20.41.2
Parametrial fat weight1.53.610.4-1.9-1.9-1.6-0.91.81.20.9-1.0-3.22.30.22.5-2.8
Pavlov. Cond. lever latency4.55.610.3-3.1-3.0-1.9-2.62.91.91.9-1.7-3.22.0-1.52.3-1.9
Pavlov. Cond. magazine entry latency2.73.48.02.02.01.41.2-1.9-1.2-1.40.92.8-2.20.2-2.42.6
Pavlov. Cond. change in total contacts1.51.64.11.51.51.20.8-1.2-0.5-0.50.92.0-1.50.2-1.51.9
Pavlov. Cond. index score4.35.510.53.02.91.92.3-2.7-1.8-1.81.53.2-2.21.2-2.52.2
Pavlov. Cond. latency score4.65.810.73.13.02.02.4-2.9-1.9-1.91.63.3-2.21.3-2.62.3
Pavlov. Cond. lever contacts4.25.09.83.13.02.02.8-2.7-1.7-1.71.92.7-1.42.0-1.81.1
Pavlov. Cond. magazine entry number1.82.25.2-1.6-1.6-1.1-1.01.51.01.0-0.7-2.31.8-0.21.9-2.1
Pavlov. Cond. intertrial magazine entries1.21.43.9-1.2-1.7-2.0-0.81.10.10.0-1.6-1.40.6-0.80.6-1.6
Pavlov. Cond. lever-magazine prob. diff.4.35.310.33.02.81.82.3-2.7-1.8-1.91.43.2-2.31.2-2.52.2
Pavlov. Cond. response bias3.03.87.72.52.41.61.9-2.2-1.4-1.51.32.8-1.91.0-2.11.9
Pavlov. Cond. lever latency0.50.72.11.11.01.01.1-0.50.1-0.31.2-0.20.81.4-0.2-0.7
Pavlov. Cond. magazine entry latency0.10.20.60.30.60.30.3-0.4-0.30.00.30.8-0.20.50.20.3
Pavlov. Cond. change in total contacts0.40.61.9-1.0-0.7-0.4-1.20.60.40.7-0.60.3-0.4-1.40.21.0
Pavlov. Cond. index score0.10.20.6-0.5-0.2-0.1-0.50.1-0.00.4-0.30.6-0.5-0.70.40.8
Pavlov. Cond. latency score0.20.20.5-0.7-0.3-0.2-0.70.30.20.5-0.40.4-0.3-0.70.50.7
Pavlov. Cond. lever contacts0.40.61.6-1.1-0.9-0.9-1.00.60.00.3-1.10.1-0.6-1.30.30.6
Pavlov. Cond. magazine entry number0.00.00.30.1-0.10.1-0.10.10.3-0.10.1-0.1-0.1-0.3-0.50.2
Pavlov. Cond. intertrial magazine entries0.81.22.01.41.21.01.0-1.3-0.6-0.80.71.1-1.20.3-1.41.4
Pavlov. Cond. lever-magazine prob. diff.0.10.20.4-0.5-0.2-0.2-0.50.1-0.00.4-0.40.5-0.4-0.60.40.6
Pavlov. Cond. response bias0.20.20.6-0.3-0.2-0.4-0.3-0.2-0.5-0.1-0.60.7-0.8-0.6-0.00.7
Time in closed arm before self-admin0.10.20.5-0.10.40.60.1-0.10.60.40.60.10.3-0.20.70.3
Time in closed arm after self-admin0.10.10.4-0.10.10.20.00.20.50.40.4-0.60.50.20.6-0.5
Time in open arm before self-admin0.70.82.20.70.50.20.2-0.6-0.7-0.7-0.11.5-1.3-0.4-1.41.4
Time in open arm after self-admin0.20.30.8-0.3-0.2-0.1-0.70.40.10.4-0.20.8-0.6-0.7-0.40.9
Bone: periosteal estimation1.22.56.30.11.12.5-0.20.92.32.32.5-0.41.71.01.60.2
Bone: periosteal perimeter0.71.24.01.01.52.00.7-0.20.70.82.00.80.41.10.30.5
Bone: post-yield work1.11.54.10.91.51.81.3-0.30.60.82.0-0.21.31.91.1-0.7
Progressive ratio test 1 active lever presses0.00.00.2-0.30.0-0.1-0.10.20.1-0.1-0.00.50.10.10.1-0.3
Progressive ratio test 1 breakpoint0.00.00.2-0.20.1-0.1-0.10.20.2-0.00.00.50.10.20.2-0.2
Progressive ratio test 1 inactive lever presses0.30.51.6-0.7-0.8-1.0-0.10.5-0.2-0.3-0.8-1.10.30.40.5-1.3
Progressive ratio test 2 active lever presses0.40.51.40.0-0.3-0.90.0-0.3-1.0-1.2-0.90.3-1.0-0.2-1.00.3
Progressive ratio test 2 breakpoint0.50.61.5-0.1-0.4-1.0-0.1-0.2-1.0-1.2-1.10.4-1.1-0.4-1.10.4
Progressive ratio test 2 inactive lever presses0.20.31.10.70.90.40.6-0.4-0.1-0.30.71.1-0.10.8-0.1-0.1
Incentive Sensitization - Responses0.60.82.20.60.1-0.50.3-0.7-1.2-1.3-0.70.6-1.5-0.1-1.51.1
Incentive Sensitization - Breakpoint0.60.82.10.4-0.1-0.70.3-0.7-1.3-1.4-0.90.4-1.4-0.2-1.41.0
Sum of active levers in priming session hrs 5-60.20.21.20.40.50.5-0.1-0.20.20.30.41.1-0.10.1-0.00.6
Progressive ratio2.74.27.3-2.6-2.2-0.5-2.52.72.52.3-0.5-2.62.1-1.12.1-0.7
Food seeking constrained by brief footshock0.20.20.7-0.7-0.6-0.4-0.80.40.20.4-0.60.1-0.1-0.6-0.00.2
Seeking ratio, punishment vs. effort1.92.76.22.11.70.61.7-2.2-1.8-1.60.42.5-1.90.5-1.81.2
Retroperitoneal fat weight0.20.83.0-0.4-0.6-1.10.10.60.3-0.2-0.5-1.40.80.81.3-1.7
Reaction time number correct1.22.34.0-2.0-2.0-1.4-1.91.91.21.2-1.1-1.81.2-1.41.0-1.2
Reaction time mean minus median0.82.03.61.91.80.91.9-1.9-1.4-1.20.91.7-1.01.0-1.10.9
Reaction time mean minus median AUC0.82.04.01.81.80.71.9-1.9-1.5-1.30.72.0-1.11.1-1.00.5
Reaction time num false alarms0.50.71.31.00.91.00.6-1.0-0.4-0.30.60.7-0.70.6-1.11.2
Reaction time num false alarms AUC0.50.82.71.01.01.30.4-0.9-0.2-0.10.80.8-0.90.3-1.11.7
Reaction time trials correct on left1.22.34.0-2.0-2.0-1.4-1.91.91.21.2-1.1-1.81.2-1.41.0-1.2
Reaction time trials on left1.22.33.9-2.0-1.9-1.4-1.81.91.31.2-1.1-1.81.2-1.41.1-1.2
Reaction time mean1.93.17.52.42.51.52.7-2.2-1.3-1.21.71.5-0.32.3-0.2-0.4
Reaction time mean AUC1.82.86.82.32.31.32.6-2.2-1.3-1.21.61.6-0.42.1-0.2-0.3
Median of all reaction times1.72.45.82.02.11.32.4-1.8-0.9-1.01.61.10.12.20.2-0.8
Reaction time omissions1.21.84.02.01.81.32.0-1.7-1.1-0.91.30.8-0.31.8-0.2-0.1
Reaction time false alarm rate2.02.85.22.02.12.11.4-1.9-0.8-0.61.41.9-1.41.0-1.62.3
Reaction time premature initiation rate0.50.71.8-0.7-0.10.6-0.30.91.21.20.6-0.71.20.41.3-0.9
Reaction time premature initiations1.32.43.9-1.8-1.3-0.2-1.42.01.91.9-0.0-1.71.9-0.51.9-1.5
Std. dev. reaction times1.52.85.82.22.41.62.0-2.1-1.0-0.81.62.3-1.01.4-0.81.2
Reaction time trials completed1.22.33.9-2.0-1.9-1.4-1.81.91.31.2-1.1-1.81.2-1.41.1-1.2
Reaction time trials AUC1.12.13.5-1.8-1.9-1.4-1.71.81.21.1-1.1-1.81.2-1.21.0-1.3
Run reversals in cocaine runway, females0.50.50.9-0.8-0.9-0.9-0.70.80.40.2-0.7-0.90.5-0.50.6-0.8
Run reversals in cocaine runway, males0.40.40.90.91.00.70.8-0.8-0.3-0.30.80.7-0.20.7-0.30.3
Latency to leave start box in cocaine runway1.21.43.31.81.51.11.7-1.5-0.7-1.01.10.9-0.41.5-0.4-0.1
Latency to leave start box in cocaine runway, F0.91.02.71.61.20.71.4-1.3-0.8-1.10.70.7-0.51.1-0.6-0.2
Latency to leave start box in cocaine runway, M0.30.31.00.80.70.70.8-0.6-0.1-0.10.70.20.21.00.2-0.1
Std. dev. time between licks in bursts2.33.18.92.02.63.01.7-1.40.30.32.71.50.12.1-0.01.0
Total sessions with >9 infusions0.30.30.9-0.7-0.5-0.4-0.90.50.20.2-0.50.8-0.3-0.9-0.50.4
Short access day 1 total inactive lever presses0.50.71.81.31.11.00.4-0.30.40.51.21.30.41.0-0.1-0.4
Short access day 10 total inactive lever presses0.30.81.71.20.70.11.3-1.1-1.1-1.10.2-0.2-0.61.3-0.5-0.3
Short access day 1 total infusions0.10.22.0-0.30.30.1-0.1-0.10.00.10.11.4-0.2-0.1-0.3-0.0
Short access day 10 total infusions0.20.20.8-0.3-0.5-0.9-0.40.2-0.4-0.4-0.90.4-0.5-0.4-0.3-0.2
Short access total infusions0.10.20.9-0.2-0.2-0.5-0.40.3-0.0-0.0-0.40.9-0.2-0.3-0.4-0.3
Short access day 1 locomotion0.70.91.90.80.7-0.11.1-1.2-1.4-1.2-0.10.6-1.10.5-1.30.5
Short access day 10 total locomotion0.71.33.0-0.90.61.5-0.30.71.71.71.6-0.41.40.71.60.4
Short access total locomotion0.20.30.9-0.10.60.70.30.00.50.50.90.10.80.60.5-0.2
One hour access (0.3 mA shock)1.82.05.81.00.5-0.51.2-1.6-2.2-2.4-0.80.8-2.00.2-1.91.2
Compulsive drug intake3.33.99.72.62.31.53.1-2.7-1.8-1.91.50.3-0.92.7-1.40.8
One hour access (shock baseline)0.91.33.5-1.3-1.4-1.8-1.30.8-0.4-0.5-1.90.2-0.7-1.7-0.40.1
Social response proportion0.80.92.30.40.71.3-0.10.61.41.41.50.31.00.60.8-0.4
Social responses0.40.51.60.30.41.1-0.50.71.21.31.00.40.40.10.30.6
Social time2.23.06.82.62.32.12.3-2.1-0.8-0.61.91.0-0.62.2-0.70.9
Soleus weight2.26.520.32.63.64.52.7-1.50.70.84.41.01.43.30.9-0.2
Bone: stiffness0.50.72.8-1.0-1.0-0.7-0.50.90.40.5-0.5-1.70.90.10.9-1.1
Tibialis anterior weight0.20.82.1-0.8-1.3-1.4-0.90.90.10.3-1.2-1.30.1-0.60.6-0.3
Time to tail flick, vehicle, before self-admin1.01.02.81.10.1-0.41.3-1.4-1.7-1.6-0.6-0.6-0.80.0-1.00.1
Time to tail flick, vehicle, after self-admin0.50.61.31.01.00.70.9-1.1-0.6-0.80.51.0-0.80.3-0.60.6
Time to tail flick, test, before self-admin0.60.61.4-0.5-0.6-0.7-0.5-0.1-0.7-0.6-1.0-0.1-1.2-1.0-1.01.1
Time to tail flick, test, after self-admin1.41.43.70.50.1-0.80.3-1.0-1.6-1.6-1.10.8-1.9-0.6-1.91.2
Delta time to tail flick, vehicle, before/after SA0.30.32.00.00.1-0.3-0.3-0.0-0.3-0.4-0.31.4-0.7-0.4-0.50.1
Delta time to tail flick, test, before/after SA0.30.30.70.4-0.0-0.70.5-0.3-0.8-0.8-0.5-0.3-0.10.4-0.2-0.8
Tibia length1.64.49.80.11.32.80.11.33.13.03.1-1.22.51.82.6-0.7
Ambulatory time before self-admin0.10.10.70.30.20.10.5-0.2-0.1-0.20.2-0.40.30.80.10.1
Ambulatory time after self-admin0.60.72.3-0.4-0.20.7-0.90.91.51.50.7-0.50.70.00.80.8
Bone: tissue strength0.40.41.2-0.5-0.2-0.2-0.20.60.60.70.2-0.50.90.20.9-1.1
Total heroin consumption0.10.10.30.30.40.50.2-0.30.1-0.10.40.2-0.10.3-0.30.5
Bone: trabecular number1.22.05.80.1-0.8-2.30.7-0.8-2.4-2.4-2.1-0.4-1.0-0.1-1.4-0.7
Bone: trabecular spacing1.51.95.9-0.40.62.0-0.71.02.42.31.9-0.01.4-0.01.50.1
Bone: trabecular thickness0.91.13.7-0.2-0.8-1.90.5-0.4-1.5-1.6-1.5-0.7-0.50.1-0.7-1.0
Bone: trabecular tissue density0.30.51.8-0.7-0.20.3-1.00.30.60.2-0.10.5-0.4-1.2-0.61.3
Water consumed over 24 hours0.20.30.70.70.80.80.6-0.5-0.00.20.80.6-0.10.70.00.4
Number of responses in last shaping day1.31.54.50.31.52.10.2-0.31.31.42.11.50.40.80.01.1