Utp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Utp6 0.06 0.05 3.7e-05 0.04 0.02 0.01 0.04 6.3e-05 1.0e-03 1.2e-02 8.3e-05
2 Adipose mRNA stability Utp6 0.08 0.09 2.3e-03 0.03 0.02 0.02 0.02 6.8e-04 6.5e-03 3.0e-03 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.64.55.12.32.0
Area under the delay curve0.10.20.3-0.6-0.1
BMI with tail0.82.83.11.61.8
BMI without tail0.72.02.21.41.5
Body weight2.611.513.03.63.2
Weight adjusted by age0.91.41.5-1.2-1.2
Bone surface0.71.21.41.21.0
Bone volume1.12.02.11.41.4
Breakpoint value in progressive ratio session1.41.72.61.60.9
Number of licking bursts0.40.61.0-1.0-0.5
Context. condit. distance diff. score0.30.40.70.80.4
Locomotion velocity, session 11.81.93.21.80.8
Locomotion distance, session 10.00.00.10.3-0.0
Locomotion velocity, session 20.10.10.10.40.1
Locomotion distance, session 20.60.91.00.81.0
Locomotion velocity, session 32.22.63.0-1.7-1.4
Locomotion distance, session 30.50.50.6-0.7-0.7
Stereotopy head waving bouts, day 30.00.10.1-0.1-0.3
Stereotopy head waving duration, day 30.30.30.3-0.6-0.5
Locomotion velocity, session 70.30.30.6-0.00.8
Locomotion distance, session 70.10.20.30.10.6
Stereotopy head waving bouts, day 70.60.71.01.00.5
Stereotopy head waving duration, day 70.30.30.60.80.3
Locomotion velocity, session 80.10.10.20.5-0.1
Locomotion distance, session 80.30.40.60.80.4
Degree of sensitization distance2.02.12.11.41.5
Degree of sensitization stereotypy0.91.01.21.10.8
Conditioned locomotion2.63.03.5-1.9-1.6
Cocaine response after cond. corrected1.41.72.60.91.6
Cocaine response after cond. not corrected2.12.53.41.31.8
Cocaine response before conditioning0.20.20.40.60.3
Saline control response0.00.10.1-0.2-0.3
Bone: connectivity density2.84.35.22.31.9
Bone: cortical apparent density0.10.20.4-0.60.0
Bone: cortical area1.62.43.4-1.8-1.2
Bone: cortical porosity0.10.10.1-0.3-0.3
Bone: cortical porosity0.10.10.2-0.5-0.1
Bone: cortical thickness2.33.85.2-2.3-1.6
Bone: cortical thickness0.20.30.5-0.70.2
Bone: cortical tissue density0.10.10.1-0.40.2
Condit. Reinf. active minus inactive responses0.30.40.7-0.90.1
Condit. Reinf. active-inactive response ratio0.20.30.5-0.7-0.2
Condit. Reinf. active responses0.10.10.1-0.20.3
Condit. Reinf. inactive responses0.10.10.10.30.1
Incentive salience index mean0.20.20.4-0.70.1
Condit. Reinf. lever presses0.10.20.20.30.5
Condit. Reinf. active minus inactive responses0.10.10.2-0.4-0.2
Condit. Reinf. active-inactive response ratio0.00.00.10.1-0.3
Condit. Reinf. active responses0.20.20.4-0.6-0.4
Condit. Reinf. inactive responses0.30.30.6-0.8-0.2
Condit. Reinf. lever presses0.81.11.7-1.3-0.8
Condit. Reinf. lever reinforcers received0.30.50.6-0.8-0.5
Conditioned reinforcement - actives0.10.20.30.4-0.5
Conditioned reinforcement - inactives0.71.01.9-0.2-1.4
Conditioned locomotion0.50.71.40.1-1.2
Patch foraging indifference point 0 sec0.20.40.7-0.80.3
Patch foraging indifference point AUC1.62.32.3-1.5-1.5
Delay disc. indifference point, 0s delay0.60.71.0-1.0-0.6
Delay disc. indifference point, 16s delay0.00.00.00.00.2
Delay disc. indifference point, 2s delay0.91.01.1-1.1-0.9
Delay disc. indifference point, 24s delay0.10.10.2-0.10.5
Delay disc. indifference point, 4s delay0.60.71.10.51.0
Delay disc. indifference point, 8s delay0.00.00.1-0.00.3
Indifference point function ln k3.15.48.71.53.0
Indifference point function log k3.15.48.71.53.0
Patch foraging total patch changes 0 sec0.20.30.6-0.80.1
Patch foraging total patch changes 12 sec0.20.20.3-0.5-0.4
Patch foraging total patch changes 18 sec0.71.11.4-1.2-0.9
Patch foraging total patch changes 24 sec0.91.51.7-1.3-1.2
Patch foraging total patch changes 6 sec2.33.54.3-2.1-1.6
Patch foraging time to switch 0 sec0.61.11.91.4-0.6
Patch foraging water rate 0 sec0.71.42.8-1.7-0.2
Patch foraging water rate 12 sec0.51.12.10.41.4
Patch foraging water rate 18 sec1.62.43.71.11.9
Patch foraging water rate 24 sec0.50.71.1-0.51.0
Patch foraging water rate 6 sec0.20.30.6-0.80.2
Seeking ratio, delayed vs. immediate footshock1.01.22.4-1.60.1
Distance traveled before self-admin2.12.82.8-1.7-1.6
Distance traveled after self-admin0.00.00.0-0.2-0.1
Extensor digitorum longus weight0.10.50.70.90.4
Bone: elastic displacement1.11.22.5-1.6-0.1
Bone: elastic work5.57.110.2-3.2-2.0
Bone: endosteal estimation0.10.20.3-0.2-0.6
Bone: endosteal perimeter0.10.20.20.50.4
Epididymis fat weight8.228.129.85.55.1
Delta time in closed arm before/after self-admin0.50.40.9-0.9-0.0
Delta time in open arm before/after self-admin2.52.53.92.01.0
Diff in mean of infusions in LGA sessions1.01.22.41.5-0.2
Delay discount exponential model param0.10.10.20.4-0.1
Extinction: sum of active levers before priming0.50.61.11.0-0.3
Active lever presses in extinction session 60.40.30.60.3-0.8
Bone: final force0.50.71.3-1.1-0.5
Bone: final moment0.40.71.1-1.1-0.5
Food consumed during 24 hour testing period0.30.40.6-0.5-0.7
Glucose0.81.32.4-1.5-0.5
Heart weight0.71.11.60.71.3
Delay discount hyperbolic model param0.20.20.40.6-0.0
Intermittent access intake day 1-15 change0.30.51.0-1.0-0.1
Intermittent access intake escalation0.20.40.9-0.9-0.0
Intermittent access intake escalation 20.70.81.5-1.20.1
Intermitt. access day 1 inactive lever presses0.31.11.1-1.0-1.0
Intermitt. access day 15 inactive lever presses2.55.18.5-1.3-2.9
Intermitt. access escalation Index1.52.24.12.00.4
Intermittent access day 1 total infusions0.40.60.90.6-0.9
Intermittent access day 15 total infusions0.20.30.50.1-0.7
Intermittent access terminal intake (last 3 days)0.20.30.60.8-0.2
Intermittent access total infusions0.20.20.40.1-0.6
Intermittent access day 1 locomotion0.60.81.5-0.2-1.2
Intermittent access day 15 total locomotion0.40.71.1-0.6-1.0
Intermittent access total locomotion0.30.40.5-0.5-0.7
Intermittent access standard deviation0.91.93.1-0.9-1.7
Left kidney weight0.20.80.90.80.9
Right kidney weight0.10.61.01.00.6
Cocaine induced anxiety0.20.20.20.50.5
Post-drug Anxiety1.21.32.31.50.5
Baseline Anxiety0.40.40.70.4-0.8
Tail length0.51.82.31.51.2
Length with tail1.35.87.62.82.0
Length without tail1.03.44.52.11.5
Times rat made contact with spout0.20.30.5-0.10.7
Lifetime Intake0.50.50.80.5-0.9
Liver weight, left5.18.412.43.52.1
Liver weight, right5.18.912.33.52.3
Locomotor activity0.50.81.60.31.3
Locomotor testing distance0.20.30.60.10.8
Locomotor testing rearing0.00.00.0-0.20.1
Locomotion in novel chamber1.62.02.9-1.7-1.1
Locomotion in novel chamber post-restriction1.22.03.50.71.9
Fecal boli incidents, locomotor time 10.20.30.50.40.7
Change in fecal boli incidents, locomotor task0.20.10.3-0.20.5
Time >=10cm from walls, locomotor time 10.40.40.7-0.80.3
Bouts of movement, locomotor time 12.12.43.1-1.3-1.8
Total resting periods, locomotor time 12.22.43.4-1.2-1.8
Rest time, locomotor task time 10.70.91.0-0.9-1.0
Distance moved, locomotor task time 10.30.50.60.50.8
Vertical activity count, locomotor time 11.12.64.21.12.0
Time >=10cm from walls, locomotor time 20.40.50.7-0.60.8
Bouts of movement, locomotor time 20.20.30.4-0.3-0.7
Total resting periods, locomotor time 20.20.30.5-0.4-0.7
Rest time, locomotor task time 21.11.41.7-1.0-1.3
Distance moved, locomotor task time 20.40.50.80.90.3
Vertical activity count, locomotor time 21.21.72.11.51.1
Light reinforcement 10.30.81.00.81.0
Light reinforcement 20.10.10.20.40.2
Bone: marrow area0.10.20.4-0.3-0.6
Bone: maximum diameter0.50.91.3-1.2-0.7
Bone: maximum force1.01.82.6-1.6-1.1
Bone: maximum moment1.01.82.4-1.5-1.1
Mean time between licks in bursts0.00.10.10.3-0.3
Mean num. licks in bursts0.50.90.90.90.9
Cd content in liver0.00.00.1-0.3-0.1
Co content in liver0.60.71.1-1.0-0.5
Cu content in liver3.13.75.1-1.5-2.3
Fe content in liver1.92.33.81.90.9
K content in liver0.10.10.20.4-0.2
Mg content in liver0.40.40.4-0.6-0.6
Mn content in liver0.80.91.1-0.7-1.1
Na content in liver1.31.42.01.40.9
Rb content in liver0.10.10.1-0.3-0.3
Se content in liver2.02.43.9-0.9-2.0
Sr content in liver0.10.10.10.3-0.0
Zn content in liver0.30.30.50.70.4
Bone: minimum diameter0.20.40.8-0.1-0.9
Time in familiar zone, hab. session 10.10.10.2-0.4-0.2
Time in novel zone, hab. session 10.20.20.20.40.4
Total zone transitions, hab. session 10.00.00.00.1-0.2
Total locomotion distance, hab. session 10.00.00.10.0-0.3
Locomotion velocity, hab. session 10.40.50.8-0.5-0.9
Time in familiar zone, hab. session 20.20.20.40.0-0.7
Time in novel zone, hab. session 20.10.10.2-0.40.3
Total zone transitions, hab. session 20.20.20.40.70.1
Total locomotion distance, hab. session 20.30.30.5-0.3-0.7
Locomotion velocity, hab. session 20.20.30.6-0.3-0.7
Novel to familiar place preference ratio1.21.42.60.31.6
Novelty place preference2.22.34.30.62.1
Time in novel zone, NPP test2.32.44.40.72.1
Total zone transitions, NPP test0.00.00.10.2-0.3
Total locomotion distance, NPP test0.91.31.3-1.1-1.2
Locomotion velocity, NPP test1.11.51.6-1.2-1.2
Intraocular pressure1.42.13.5-1.9-0.8
Delta distance traveled before/after self-admin1.81.92.01.31.4
Delta ambulatory time before/after self-admin2.32.83.21.51.8
Parametrial fat weight6.615.617.54.23.7
Pavlov. Cond. lever latency0.00.00.1-0.2-0.0
Pavlov. Cond. magazine entry latency0.20.30.50.70.2
Pavlov. Cond. change in total contacts0.20.30.50.1-0.7
Pavlov. Cond. index score0.10.10.20.40.0
Pavlov. Cond. latency score0.10.20.30.60.1
Pavlov. Cond. lever contacts0.10.10.20.40.1
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.1
Pavlov. Cond. intertrial magazine entries0.60.71.0-1.0-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.3-0.1
Pavlov. Cond. response bias0.10.10.30.50.2
Pavlov. Cond. lever latency0.81.11.81.40.6
Pavlov. Cond. magazine entry latency0.10.10.30.00.5
Pavlov. Cond. change in total contacts0.40.71.3-1.1-0.2
Pavlov. Cond. index score0.60.81.6-1.2-0.4
Pavlov. Cond. latency score0.81.11.9-1.4-0.5
Pavlov. Cond. lever contacts0.40.61.1-1.0-0.2
Pavlov. Cond. magazine entry number0.20.30.50.1-0.7
Pavlov. Cond. intertrial magazine entries0.10.20.20.40.4
Pavlov. Cond. lever-magazine prob. diff.0.40.51.0-1.0-0.1
Pavlov. Cond. response bias0.20.20.5-0.7-0.1
Time in closed arm before self-admin2.83.64.51.62.1
Time in closed arm after self-admin0.20.30.5-0.20.7
Time in open arm before self-admin3.13.44.9-2.2-1.4
Time in open arm after self-admin0.10.10.20.1-0.5
Bone: periosteal estimation0.61.31.4-1.2-1.1
Bone: periosteal perimeter0.10.10.2-0.50.0
Bone: post-yield work0.00.10.10.3-0.1
Progressive ratio test 1 active lever presses0.91.12.1-0.3-1.5
Progressive ratio test 1 breakpoint1.11.32.5-0.4-1.6
Progressive ratio test 1 inactive lever presses2.84.15.5-1.6-2.3
Progressive ratio test 2 active lever presses1.51.82.4-1.1-1.5
Progressive ratio test 2 breakpoint1.71.92.7-1.1-1.6
Progressive ratio test 2 inactive lever presses0.71.21.4-1.2-1.0
Incentive Sensitization - Responses0.30.50.6-0.6-0.8
Incentive Sensitization - Breakpoint0.30.40.6-0.6-0.7
Sum of active levers in priming session hrs 5-61.71.62.31.50.9
Progressive ratio1.11.72.0-1.2-1.4
Food seeking constrained by brief footshock0.00.00.10.3-0.2
Seeking ratio, punishment vs. effort0.71.01.20.91.1
Retroperitoneal fat weight1.98.28.82.83.0
Reaction time number correct0.71.32.6-0.21.6
Reaction time mean minus median0.10.30.60.80.1
Reaction time mean minus median AUC0.82.02.71.71.1
Reaction time num false alarms2.73.85.3-2.3-1.5
Reaction time num false alarms AUC3.45.36.9-2.6-1.9
Reaction time trials correct on left0.71.32.6-0.21.6
Reaction time trials on left0.71.42.7-0.21.6
Reaction time mean0.71.11.61.30.7
Reaction time mean AUC0.50.81.21.10.6
Median of all reaction times0.71.01.31.10.8
Reaction time omissions1.42.12.61.31.6
Reaction time false alarm rate3.75.15.8-2.1-2.4
Reaction time premature initiation rate1.11.62.21.51.0
Reaction time premature initiations0.91.62.21.01.5
Std. dev. reaction times0.20.40.70.80.2
Reaction time trials completed0.71.42.7-0.21.6
Reaction time trials AUC0.71.42.7-0.31.7
Run reversals in cocaine runway, females0.20.20.20.4-0.5
Run reversals in cocaine runway, males0.00.00.10.20.3
Latency to leave start box in cocaine runway0.70.81.3-0.6-1.1
Latency to leave start box in cocaine runway, F0.10.10.20.0-0.5
Latency to leave start box in cocaine runway, M1.41.32.1-0.7-1.5
Std. dev. time between licks in bursts0.50.70.7-0.9-0.8
Total sessions with >9 infusions0.60.81.11.0-0.7
Short access day 1 total inactive lever presses0.91.22.11.40.5
Short access day 10 total inactive lever presses0.20.50.8-0.9-0.3
Short access day 1 total infusions0.40.50.80.6-0.9
Short access day 10 total infusions0.60.71.21.1-0.5
Short access total infusions0.70.91.40.7-1.2
Short access day 1 locomotion0.60.71.4-0.2-1.2
Short access day 10 total locomotion1.12.12.2-1.5-1.4
Short access total locomotion2.12.53.9-1.0-2.0
One hour access (0.3 mA shock)0.50.61.0-0.4-1.0
Compulsive drug intake0.70.81.51.20.4
One hour access (shock baseline)0.30.50.6-0.7-0.8
Social response proportion2.32.62.61.61.6
Social responses0.50.60.80.70.9
Social time0.50.60.91.00.6
Soleus weight2.67.69.13.02.5
Bone: stiffness0.30.60.90.90.5
Tibialis anterior weight1.03.55.02.21.4
Time to tail flick, vehicle, before self-admin0.30.40.70.80.2
Time to tail flick, vehicle, after self-admin0.70.91.60.41.3
Time to tail flick, test, before self-admin0.30.30.6-0.20.7
Time to tail flick, test, after self-admin0.60.70.7-0.8-0.8
Delta time to tail flick, vehicle, before/after SA0.50.50.6-0.60.8
Delta time to tail flick, test, before/after SA1.92.03.4-0.7-1.8
Tibia length0.00.00.1-0.3-0.1
Ambulatory time before self-admin0.50.70.7-0.9-0.8
Ambulatory time after self-admin1.11.31.70.91.3
Bone: tissue strength0.30.30.4-0.6-0.4
Total heroin consumption1.72.03.21.80.9
Bone: trabecular number3.25.36.32.52.1
Bone: trabecular spacing1.01.31.6-1.3-1.0
Bone: trabecular thickness0.30.30.50.50.7
Bone: trabecular tissue density0.50.81.1-1.1-0.6
Water consumed over 24 hours0.20.30.30.50.5
Number of responses in last shaping day0.60.60.7-0.7-0.9