Hub : Genes

Usp13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Usp13 0.4 0.17 2.1e-04 0.18 0.25 0.14 0.18 1.0e-03 1.1e-04 3.7e-03 8.8e-04
2 NAcc intron excision ratio chr2_115658975_115661336 0.03 0.02 7.4e-03 0.01 0.01 0.01 0 3.2e-02 1.5e-02 4.6e-02 7.8e-02
3 BLA gene expression Usp13 0.05 0.04 8.1e-03 0.01 0.01 0 0.01 7.0e-02 5.7e-02 3.1e-01 1.4e-01
4 PL gene expression Usp13 0.07 0.04 1.0e-09 0.06 0.08 0.09 0.07 2.1e-07 5.3e-09 3.8e-10 1.7e-08
5 Brain mRNA stability Usp13 0.37 0.12 0.0e+00 0.23 0.24 0.24 0.24 1.3e-21 5.8e-22 2.6e-22 6.8e-22
6 Adipose gene expression Usp13 0.03 0.02 2.4e-03 0.01 0 0.01 0 3.5e-02 1.3e-01 1.7e-02 1.7e-01
7 PL mRNA stability Usp13 0.11 0.06 5.0e-05 0.05 0.03 0.04 0.04 6.1e-06 1.6e-04 6.2e-05 1.2e-05
8 Brain gene expression Usp13 0.08 0.05 6.9e-07 0.05 0.06 0.08 0.06 4.3e-05 1.5e-06 1.3e-07 2.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.03.36.52.52.52.3-1.90.5-1.70.7-1.2
Area under the delay curve1.11.22.31.21.01.3-1.20.6-1.20.3-1.5
BMI with tail0.41.42.41.51.01.5-1.5-1.0-0.8-1.0-0.5
BMI without tail0.81.73.51.91.41.9-1.50.0-1.20.0-1.0
Body weight0.10.31.00.0-0.2-0.00.2-1.00.8-0.80.4
Weight adjusted by age1.21.43.5-1.4-0.7-1.50.8-0.01.50.21.9
Bone surface0.10.21.00.31.00.1-0.2-0.10.8-0.00.2
Bone volume0.30.52.10.61.50.3-0.40.50.50.60.1
Breakpoint value in progressive ratio session2.22.44.01.90.92.0-1.4-1.5-2.0-1.4-0.7
Number of licking bursts1.31.63.81.50.31.7-0.4-0.7-1.6-0.7-2.0
Context. condit. distance diff. score3.03.76.42.22.52.0-1.51.4-2.31.2-1.7
Locomotion velocity, session 13.13.47.4-1.3-2.1-1.11.6-2.71.0-2.71.2
Locomotion distance, session 11.11.44.1-0.5-1.3-0.40.4-2.00.9-1.90.8
Locomotion velocity, session 24.35.010.3-1.5-2.7-1.32.3-3.21.0-3.21.5
Locomotion distance, session 21.52.23.6-1.1-1.5-1.00.9-1.91.6-1.81.6
Locomotion velocity, session 30.10.10.5-0.1-0.2-0.1-0.0-0.70.1-0.60.3
Locomotion distance, session 30.20.20.7-0.4-0.8-0.30.5-0.5-0.1-0.50.3
Stereotopy head waving bouts, day 30.20.20.4-0.3-0.4-0.30.0-0.60.6-0.60.2
Stereotopy head waving duration, day 30.40.51.50.90.60.9-1.2-0.4-0.3-0.4-0.6
Locomotion velocity, session 71.11.22.5-0.9-0.5-1.10.6-1.41.0-1.61.3
Locomotion distance, session 70.50.61.4-0.9-0.5-1.00.8-0.10.6-0.41.2
Stereotopy head waving bouts, day 70.80.92.41.40.41.6-0.9-0.6-1.0-0.5-0.7
Stereotopy head waving duration, day 71.01.22.41.50.51.6-1.1-1.0-0.9-1.0-0.7
Locomotion velocity, session 81.41.73.21.71.01.7-1.1-0.8-1.8-0.7-1.2
Locomotion distance, session 80.30.51.51.01.20.7-0.50.1-0.60.0-0.5
Degree of sensitization distance0.80.81.5-1.0-0.1-1.21.00.61.00.51.1
Degree of sensitization stereotypy1.21.33.21.60.71.8-1.2-0.3-1.3-0.2-0.9
Conditioned locomotion0.60.72.80.00.7-0.10.21.70.31.60.2
Cocaine response after cond. corrected0.80.93.5-0.20.3-0.2-0.21.90.51.7-0.4
Cocaine response after cond. not corrected0.60.71.7-0.7-0.1-0.80.21.31.11.2-0.1
Cocaine response before conditioning0.30.31.4-0.2-0.1-0.3-0.0-1.20.2-1.10.1
Saline control response0.50.71.5-1.1-0.4-1.20.2-0.71.2-0.60.6
Bone: connectivity density1.01.63.31.81.51.8-1.4-0.4-1.3-0.1-0.5
Bone: cortical apparent density0.10.10.70.20.20.2-0.1-0.0-0.10.10.9
Bone: cortical area0.30.41.1-0.11.0-0.4-0.30.41.00.40.8
Bone: cortical porosity0.30.32.10.10.20.1-1.50.20.40.2-0.6
Bone: cortical porosity0.40.42.60.00.5-0.0-1.60.00.60.1-0.4
Bone: cortical thickness0.40.71.80.31.3-0.0-1.01.10.31.10.2
Bone: cortical thickness0.70.81.9-0.3-1.1-0.21.0-1.4-0.5-1.3-0.5
Bone: cortical tissue density0.10.10.70.30.20.2-0.1-0.1-0.10.00.8
Condit. Reinf. active minus inactive responses1.51.72.3-1.5-1.4-1.51.4-1.01.3-1.01.1
Condit. Reinf. active-inactive response ratio1.11.22.4-1.4-1.0-1.41.10.21.60.11.0
Condit. Reinf. active responses1.82.35.7-1.1-1.2-1.10.8-2.40.9-2.41.1
Condit. Reinf. inactive responses1.82.18.40.2-0.20.2-0.4-2.9-0.6-2.80.0
Incentive salience index mean1.72.02.9-1.7-1.5-1.71.5-1.01.4-1.11.2
Condit. Reinf. lever presses0.81.12.3-1.1-1.0-1.10.6-1.50.7-1.50.7
Condit. Reinf. active minus inactive responses0.91.22.0-1.4-0.9-1.40.7-0.80.9-0.91.3
Condit. Reinf. active-inactive response ratio0.80.91.5-1.2-0.7-1.20.80.61.00.71.1
Condit. Reinf. active responses2.63.74.7-2.1-1.7-2.21.5-2.11.5-2.21.9
Condit. Reinf. inactive responses2.53.17.5-1.4-1.7-1.31.3-2.60.9-2.71.0
Condit. Reinf. lever presses0.20.20.4-0.6-0.2-0.70.5-0.30.6-0.40.3
Condit. Reinf. lever reinforcers received2.53.54.6-2.0-1.6-2.11.4-2.11.5-2.11.9
Conditioned reinforcement - actives0.50.51.1-0.7-0.9-0.61.0-0.30.8-0.20.4
Conditioned reinforcement - inactives0.10.10.5-0.1-0.3-0.10.1-0.10.20.20.7
Conditioned locomotion1.82.26.3-0.6-1.4-0.50.6-2.50.3-2.51.4
Patch foraging indifference point 0 sec0.81.42.71.61.01.6-0.7-0.0-1.60.1-1.2
Patch foraging indifference point AUC1.51.72.71.20.01.4-0.8-1.6-1.6-1.7-1.5
Delay disc. indifference point, 0s delay0.40.51.5-0.6-0.5-0.70.4-0.90.4-1.20.3
Delay disc. indifference point, 16s delay1.51.52.71.41.21.3-1.50.4-1.60.1-1.4
Delay disc. indifference point, 2s delay0.50.61.00.80.90.8-0.90.5-0.70.4-1.0
Delay disc. indifference point, 24s delay1.31.31.71.31.31.2-1.30.9-1.11.1-0.6
Delay disc. indifference point, 4s delay0.30.30.80.50.00.6-0.3-0.4-0.7-0.7-0.9
Delay disc. indifference point, 8s delay0.40.41.30.60.30.6-0.50.8-0.30.3-1.2
Indifference point function ln k1.52.13.9-1.3-0.1-1.51.32.01.42.01.0
Indifference point function log k1.52.13.9-1.3-0.1-1.51.32.01.42.01.0
Patch foraging total patch changes 0 sec0.91.53.01.61.01.7-0.80.0-1.70.2-1.4
Patch foraging total patch changes 12 sec1.21.63.21.60.81.8-1.4-0.2-1.50.1-1.4
Patch foraging total patch changes 18 sec1.21.63.61.50.41.7-0.6-0.6-1.9-0.7-1.6
Patch foraging total patch changes 24 sec3.64.47.82.81.82.8-1.8-1.0-2.6-0.6-2.2
Patch foraging total patch changes 6 sec3.55.29.32.91.83.1-2.2-0.5-2.8-0.3-2.7
Patch foraging time to switch 0 sec0.20.30.8-0.30.1-0.30.20.80.50.90.3
Patch foraging water rate 0 sec0.30.50.80.90.80.9-0.90.2-0.70.3-0.7
Patch foraging water rate 12 sec0.10.10.4-0.10.1-0.1-0.40.20.20.30.6
Patch foraging water rate 18 sec0.30.40.9-0.4-0.7-0.30.6-1.00.4-0.50.8
Patch foraging water rate 24 sec1.01.42.41.51.11.5-1.0-1.2-1.2-1.1-0.6
Patch foraging water rate 6 sec0.00.00.10.1-0.00.2-0.3-0.3-0.1-0.2-0.0
Seeking ratio, delayed vs. immediate footshock0.50.51.30.70.90.7-1.10.1-1.00.1-0.5
Distance traveled before self-admin1.31.42.41.61.41.5-1.50.3-1.10.4-0.8
Distance traveled after self-admin0.50.50.90.90.21.0-0.6-0.7-0.6-0.9-0.5
Extensor digitorum longus weight0.41.45.40.5-0.10.5-0.1-2.3-0.3-2.20.6
Bone: elastic displacement0.50.52.2-0.10.3-0.1-0.11.40.11.50.1
Bone: elastic work1.01.33.6-1.00.2-1.30.50.91.91.21.3
Bone: endosteal estimation0.81.83.4-1.1-0.4-1.31.5-1.51.8-1.61.0
Bone: endosteal perimeter0.61.22.5-1.1-0.8-1.21.2-0.91.6-0.90.6
Epididymis fat weight0.71.52.2-1.4-1.2-1.41.4-0.91.5-0.81.0
Delta time in closed arm before/after self-admin0.20.20.80.30.90.1-0.9-0.10.10.10.2
Delta time in open arm before/after self-admin0.40.40.8-0.5-0.9-0.30.90.60.30.4-0.5
Diff in mean of infusions in LGA sessions0.30.41.50.50.90.3-1.20.0-0.6-0.20.2
Delay discount exponential model param1.31.42.5-1.3-1.0-1.41.4-0.71.2-0.41.6
Extinction: sum of active levers before priming0.20.20.8-0.3-0.0-0.50.4-0.30.4-0.40.9
Active lever presses in extinction session 60.10.10.30.30.10.3-0.1-0.3-0.5-0.2-0.2
Bone: final force0.61.02.3-0.80.2-1.10.6-1.11.5-1.01.0
Bone: final moment0.40.71.9-0.50.5-0.90.3-0.81.4-0.81.0
Food consumed during 24 hour testing period0.10.10.3-0.10.1-0.10.40.50.30.50.1
Glucose1.21.73.1-1.6-1.3-1.61.60.71.80.60.7
Heart weight0.30.51.30.70.80.6-1.1-0.7-0.3-0.70.0
Delay discount hyperbolic model param1.01.02.0-1.1-0.9-1.11.2-0.61.0-0.31.4
Intermittent access intake day 1-15 change0.90.91.50.90.11.1-0.9-0.8-1.2-1.1-1.0
Intermittent access intake escalation0.70.71.80.7-0.10.9-0.9-0.6-1.4-1.0-0.7
Intermittent access intake escalation 20.30.31.4-0.2-0.6-0.1-0.2-0.8-0.4-1.20.0
Intermitt. access day 1 inactive lever presses0.20.20.8-0.3-0.2-0.40.1-0.20.6-0.10.9
Intermitt. access day 15 inactive lever presses0.40.52.0-0.7-1.4-0.50.7-0.4-0.1-0.40.3
Intermitt. access escalation Index0.20.10.3-0.2-0.1-0.20.50.30.60.4-0.4
Intermittent access day 1 total infusions2.83.35.0-2.2-2.2-2.02.2-0.61.9-0.41.8
Intermittent access day 15 total infusions0.91.02.4-0.5-1.5-0.30.6-1.5-0.2-1.60.4
Intermittent access terminal intake (last 3 days)2.32.55.4-1.5-2.3-1.21.3-1.90.8-1.81.3
Intermittent access total infusions2.22.55.2-1.4-2.3-1.21.4-1.80.9-1.71.4
Intermittent access day 1 locomotion1.21.21.6-1.0-1.2-1.01.0-1.31.1-1.01.3
Intermittent access day 15 total locomotion1.61.74.71.00.01.1-1.2-2.2-1.1-2.00.3
Intermittent access total locomotion1.92.17.8-0.1-1.30.1-0.0-2.8-0.3-2.60.8
Intermittent access standard deviation0.10.20.50.40.30.5-0.30.2-0.70.1-0.1
Left kidney weight0.10.31.10.51.10.2-0.60.50.10.70.5
Right kidney weight0.20.61.11.10.91.0-0.8-0.4-1.0-0.3-0.0
Cocaine induced anxiety0.50.61.4-0.6-1.1-0.51.0-1.20.3-0.80.0
Post-drug Anxiety1.11.33.3-1.2-1.8-1.01.3-1.20.3-1.00.2
Baseline Anxiety0.50.61.40.60.60.6-1.20.7-1.00.2-0.4
Tail length0.20.51.80.20.50.10.31.20.21.3-0.2
Length with tail0.30.92.0-0.9-0.3-1.01.30.91.41.00.3
Length without tail1.02.35.3-1.8-0.7-2.01.6-0.22.3-0.01.6
Times rat made contact with spout0.80.91.8-1.1-1.1-1.01.40.40.80.30.9
Lifetime Intake2.32.65.5-1.7-2.3-1.51.6-1.51.0-1.31.6
Liver weight, left1.22.04.6-1.4-2.1-1.22.0-1.00.3-1.21.3
Liver weight, right0.10.20.7-0.4-0.5-0.40.2-0.20.10.00.8
Locomotor activity2.33.68.0-2.3-1.3-2.50.7-0.82.8-0.72.5
Locomotor testing distance1.52.54.5-1.5-1.0-1.6-0.1-1.71.9-1.82.1
Locomotor testing rearing0.50.72.4-0.6-0.0-0.7-0.7-0.90.8-0.91.5
Locomotion in novel chamber0.60.81.9-0.4-1.2-0.10.7-1.40.1-1.40.4
Locomotion in novel chamber post-restriction0.20.20.60.30.70.2-0.70.60.20.6-0.4
Fecal boli incidents, locomotor time 11.01.11.9-1.3-1.0-1.21.40.61.30.40.5
Change in fecal boli incidents, locomotor task0.60.51.60.80.20.9-0.8-0.7-1.3-0.30.1
Time >=10cm from walls, locomotor time 10.20.20.4-0.20.1-0.30.40.60.50.60.1
Bouts of movement, locomotor time 10.20.20.4-0.40.5-0.6-0.40.50.40.40.3
Total resting periods, locomotor time 10.40.41.3-0.40.3-0.6-0.31.20.41.00.1
Rest time, locomotor task time 10.60.71.2-1.1-1.1-1.00.8-0.20.9-0.40.8
Distance moved, locomotor task time 10.60.61.11.10.71.0-0.5-0.6-0.8-0.4-0.9
Vertical activity count, locomotor time 10.60.71.31.10.91.1-0.40.3-0.90.5-0.8
Time >=10cm from walls, locomotor time 20.30.30.4-0.5-0.5-0.40.60.50.30.60.6
Bouts of movement, locomotor time 20.80.82.70.30.70.2-0.51.6-0.61.3-1.0
Total resting periods, locomotor time 20.60.62.40.10.50.1-0.51.6-0.41.1-0.8
Rest time, locomotor task time 20.10.10.50.20.30.2-0.70.30.2-0.20.2
Distance moved, locomotor task time 20.40.41.7-0.2-0.7-0.20.4-1.3-0.2-1.00.1
Vertical activity count, locomotor time 21.01.02.3-0.8-1.5-0.61.1-1.40.3-1.10.9
Light reinforcement 10.40.82.3-0.90.1-1.2-0.30.51.30.31.5
Light reinforcement 20.10.10.3-0.3-0.2-0.30.3-0.10.2-0.00.6
Bone: marrow area0.71.62.7-0.9-0.3-1.21.4-1.51.6-1.60.9
Bone: maximum diameter0.10.20.6-0.10.6-0.30.2-0.20.8-0.10.3
Bone: maximum force0.61.02.9-1.00.1-1.30.9-0.41.7-0.61.1
Bone: maximum moment0.50.82.6-0.80.4-1.20.7-0.21.6-0.41.0
Mean time between licks in bursts1.11.52.6-1.3-0.1-1.50.41.41.41.31.6
Mean num. licks in bursts1.72.04.5-1.7-0.9-1.80.70.91.50.82.1
Cd content in liver1.31.44.5-1.3-1.5-1.10.4-0.90.3-0.82.1
Co content in liver0.60.61.5-0.6-1.2-0.40.2-1.0-0.0-1.00.9
Cu content in liver0.30.40.7-0.7-0.5-0.70.80.60.80.7-0.1
Fe content in liver0.30.40.6-0.8-0.7-0.70.30.60.50.8-0.3
K content in liver1.31.23.11.01.80.7-0.81.4-0.01.5-0.8
Mg content in liver1.61.64.50.41.70.1-0.72.10.72.1-0.2
Mn content in liver0.91.03.10.31.20.1-0.31.80.31.7-0.3
Na content in liver1.01.01.81.40.91.4-0.9-0.4-1.0-0.4-1.2
Rb content in liver0.40.52.50.60.70.5-1.60.4-0.10.50.1
Se content in liver0.60.81.9-1.1-1.4-0.91.0-0.70.5-0.60.1
Sr content in liver1.11.02.60.4-0.80.70.2-1.5-1.4-1.6-0.6
Zn content in liver1.21.34.80.10.80.0-0.02.20.72.1-0.6
Bone: minimum diameter0.81.54.7-1.30.3-1.71.00.22.20.21.2
Time in familiar zone, hab. session 10.30.30.9-0.3-0.9-0.21.0-0.3-0.0-0.30.0
Time in novel zone, hab. session 12.01.94.81.61.81.4-2.20.2-1.30.2-0.9
Total zone transitions, hab. session 10.50.72.10.80.70.8-1.4-0.9-0.2-0.8-0.2
Total locomotion distance, hab. session 11.72.46.41.91.81.7-2.5-0.9-0.9-0.6-0.9
Locomotion velocity, hab. session 11.52.15.81.71.71.6-2.4-0.8-0.8-0.5-0.9
Time in familiar zone, hab. session 20.10.10.2-0.3-0.0-0.3-0.20.40.20.2-0.1
Time in novel zone, hab. session 20.70.71.61.21.01.2-1.2-0.3-0.4-0.1-0.0
Total zone transitions, hab. session 20.30.31.1-0.1-0.4-0.0-0.4-1.10.5-0.90.4
Total locomotion distance, hab. session 20.10.20.60.30.10.4-0.7-0.80.1-0.4-0.1
Locomotion velocity, hab. session 20.10.21.00.1-0.20.2-0.4-1.00.2-0.60.1
Novel to familiar place preference ratio6.26.411.23.02.92.9-3.41.5-2.31.5-2.0
Novelty place preference8.08.113.73.43.33.3-3.71.6-2.71.7-2.3
Time in novel zone, NPP test8.68.915.23.63.53.4-3.91.7-2.81.7-2.4
Total zone transitions, NPP test1.62.34.9-1.2-1.7-1.11.1-2.20.8-2.20.9
Total locomotion distance, NPP test0.60.92.3-0.7-1.0-0.60.4-1.50.7-1.30.4
Locomotion velocity, NPP test0.81.22.5-1.0-1.2-0.90.5-1.61.0-1.40.6
Intraocular pressure0.71.02.0-1.3-1.1-1.30.5-0.41.0-0.51.4
Delta distance traveled before/after self-admin0.80.92.0-1.0-1.4-0.90.9-0.80.6-1.00.7
Delta ambulatory time before/after self-admin0.60.71.4-0.7-1.2-0.60.8-0.90.2-1.10.4
Parametrial fat weight0.40.82.5-0.3-0.5-0.41.0-1.6-0.0-1.40.9
Pavlov. Cond. lever latency1.11.43.41.41.61.3-1.90.6-0.80.5-0.6
Pavlov. Cond. magazine entry latency0.10.10.30.10.10.10.50.0-0.6-0.1-0.2
Pavlov. Cond. change in total contacts0.40.41.2-0.6-0.9-0.51.1-0.4-0.4-0.5-0.2
Pavlov. Cond. index score0.81.02.3-0.6-1.3-0.51.5-1.2-0.4-1.30.1
Pavlov. Cond. latency score1.01.23.1-1.0-1.5-0.91.8-1.10.1-1.20.5
Pavlov. Cond. lever contacts1.41.63.8-1.4-1.5-1.41.9-1.10.7-1.10.8
Pavlov. Cond. magazine entry number0.40.61.5-0.40.4-0.5-0.70.91.21.00.4
Pavlov. Cond. intertrial magazine entries0.30.30.8-0.5-0.1-0.5-0.30.80.50.90.5
Pavlov. Cond. lever-magazine prob. diff.0.60.71.6-0.5-1.1-0.31.2-1.1-0.5-1.2-0.0
Pavlov. Cond. response bias0.50.61.20.2-0.60.30.8-1.1-1.0-1.1-0.3
Pavlov. Cond. lever latency0.30.30.7-0.4-0.1-0.50.40.80.60.90.7
Pavlov. Cond. magazine entry latency0.20.30.70.4-0.10.50.10.7-0.80.90.2
Pavlov. Cond. change in total contacts0.60.81.4-0.9-1.2-0.70.6-1.20.6-1.10.3
Pavlov. Cond. index score0.20.20.50.3-0.30.40.2-0.7-0.7-0.7-0.3
Pavlov. Cond. latency score0.20.20.40.2-0.40.30.3-0.6-0.6-0.6-0.2
Pavlov. Cond. lever contacts0.40.50.70.80.50.9-0.8-0.4-0.8-0.4-0.8
Pavlov. Cond. magazine entry number0.30.31.2-0.70.0-0.80.10.51.10.30.2
Pavlov. Cond. intertrial magazine entries0.50.72.2-0.5-0.2-0.60.5-1.50.5-1.50.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.2-0.50.30.2-0.8-0.6-0.7-0.2
Pavlov. Cond. response bias0.30.40.60.70.40.8-0.8-0.2-0.8-0.1-0.6
Time in closed arm before self-admin0.10.20.20.40.30.5-0.40.4-0.50.2-0.5
Time in closed arm after self-admin0.20.20.60.10.6-0.0-0.80.60.10.6-0.2
Time in open arm before self-admin0.60.61.50.90.80.8-1.1-0.4-1.2-0.20.2
Time in open arm after self-admin0.10.10.20.1-0.20.20.40.2-0.40.3-0.1
Bone: periosteal estimation0.51.13.5-0.80.3-1.20.9-0.81.9-0.81.0
Bone: periosteal perimeter0.30.41.9-0.70.2-0.90.2-0.01.4-0.10.4
Bone: post-yield work1.21.64.2-1.4-1.7-1.32.0-0.11.4-0.40.7
Progressive ratio test 1 active lever presses1.81.92.5-1.3-1.5-1.31.2-1.51.4-1.01.6
Progressive ratio test 1 breakpoint2.12.23.2-1.4-1.6-1.41.3-1.71.5-1.31.8
Progressive ratio test 1 inactive lever presses1.11.22.0-1.0-1.4-0.91.1-1.31.0-1.01.0
Progressive ratio test 2 active lever presses1.51.63.8-0.8-1.8-0.60.8-1.9-0.2-1.80.9
Progressive ratio test 2 breakpoint1.41.64.7-0.5-1.7-0.20.5-2.2-0.5-2.00.4
Progressive ratio test 2 inactive lever presses0.70.92.5-0.7-1.6-0.50.9-1.1-0.2-1.10.5
Incentive Sensitization - Responses1.11.13.30.1-1.00.3-0.3-1.8-1.0-1.80.3
Incentive Sensitization - Breakpoint1.11.23.4-0.0-1.20.2-0.1-1.8-1.0-1.80.3
Sum of active levers in priming session hrs 5-62.52.43.7-1.6-1.8-1.51.8-1.11.4-1.21.9
Progressive ratio0.10.10.3-0.5-0.3-0.50.1-0.40.5-0.40.2
Food seeking constrained by brief footshock0.20.30.70.30.80.1-0.60.60.30.3-0.8
Seeking ratio, punishment vs. effort0.50.60.80.90.90.9-0.70.7-0.90.4-0.9
Retroperitoneal fat weight0.41.42.3-1.0-0.7-1.10.7-1.51.2-1.41.5
Reaction time number correct2.94.28.7-2.1-3.0-1.81.8-2.21.4-1.92.0
Reaction time mean minus median0.30.41.5-0.1-0.20.00.11.20.11.2-0.2
Reaction time mean minus median AUC0.20.30.50.50.10.6-0.50.7-0.40.7-0.4
Reaction time num false alarms0.10.21.00.10.10.1-1.0-0.4-0.2-0.40.2
Reaction time num false alarms AUC0.10.20.4-0.0-0.20.0-0.6-0.6-0.3-0.60.3
Reaction time trials correct on left2.94.28.7-2.1-3.0-1.81.8-2.21.4-1.92.0
Reaction time trials on left2.94.28.8-2.1-3.0-1.81.8-2.11.5-1.82.0
Reaction time mean0.91.22.3-1.5-1.4-1.41.10.80.80.80.5
Reaction time mean AUC0.71.01.8-1.3-1.2-1.20.80.90.81.00.3
Median of all reaction times0.71.02.2-1.5-1.4-1.31.00.50.70.50.3
Reaction time omissions1.41.95.3-0.90.3-1.10.22.31.72.30.3
Reaction time false alarm rate0.81.22.81.11.31.0-1.70.5-1.10.2-0.9
Reaction time premature initiation rate0.91.21.91.11.31.1-0.61.3-0.91.1-1.4
Reaction time premature initiations0.10.10.3-0.2-0.5-0.10.5-0.00.00.0-0.1
Std. dev. reaction times0.20.31.1-0.4-0.4-0.30.41.10.11.10.0
Reaction time trials completed2.94.28.8-2.1-3.0-1.81.8-2.11.5-1.82.0
Reaction time trials AUC2.84.08.0-2.1-2.8-1.81.8-2.01.6-1.71.9
Run reversals in cocaine runway, females0.40.40.70.5-0.20.6-0.1-0.9-0.8-0.9-0.5
Run reversals in cocaine runway, males0.70.61.9-0.6-0.7-0.60.5-1.20.1-1.40.5
Latency to leave start box in cocaine runway0.20.20.6-0.3-0.1-0.30.40.80.10.8-0.4
Latency to leave start box in cocaine runway, F0.20.30.7-0.4-0.0-0.40.40.80.50.7-0.4
Latency to leave start box in cocaine runway, M0.20.20.50.10.20.10.00.6-0.70.7-0.1
Std. dev. time between licks in bursts0.50.61.2-0.70.1-0.90.60.90.91.10.5
Total sessions with >9 infusions1.41.52.8-1.5-0.9-1.61.20.41.70.71.4
Short access day 1 total inactive lever presses1.41.64.40.90.01.0-0.7-2.1-1.3-2.00.0
Short access day 10 total inactive lever presses1.11.21.91.41.01.4-1.2-0.0-1.4-0.5-1.1
Short access day 1 total infusions0.80.91.4-0.9-1.0-0.91.1-1.10.7-0.41.2
Short access day 10 total infusions1.41.62.5-1.4-1.6-1.31.2-0.81.3-0.31.6
Short access total infusions1.92.23.3-1.8-1.8-1.71.6-0.81.4-0.21.7
Short access day 1 locomotion0.60.62.00.7-0.00.7-0.5-1.4-0.6-1.0-0.3
Short access day 10 total locomotion0.30.30.60.80.40.8-0.6-0.6-0.3-0.4-0.0
Short access total locomotion0.70.71.4-0.7-1.0-0.60.4-1.20.7-0.71.0
One hour access (0.3 mA shock)0.91.02.4-0.8-1.6-0.60.8-1.20.2-1.21.0
Compulsive drug intake0.30.30.9-0.6-0.3-0.70.6-0.41.0-0.30.5
One hour access (shock baseline)0.91.03.2-1.0-1.8-0.80.9-0.8-0.0-0.91.0
Social response proportion1.82.03.2-1.8-1.3-1.81.70.51.80.61.1
Social responses0.10.10.30.30.10.4-0.5-0.5-0.0-0.5-0.2
Social time2.53.36.1-2.3-1.2-2.30.81.72.51.31.9
Soleus weight6.418.734.25.65.85.2-5.01.6-3.91.4-3.4
Bone: stiffness0.20.31.2-0.50.3-0.70.10.21.1-0.20.4
Tibialis anterior weight0.62.17.90.90.30.9-0.0-2.8-0.9-2.6-0.2
Time to tail flick, vehicle, before self-admin1.41.43.3-1.1-0.4-1.10.71.41.11.81.3
Time to tail flick, vehicle, after self-admin1.11.22.8-1.3-1.6-1.11.70.60.70.40.3
Time to tail flick, test, before self-admin2.52.43.91.41.91.3-1.71.8-1.02.0-1.1
Time to tail flick, test, after self-admin3.23.46.71.91.91.9-1.51.5-1.91.2-2.6
Delta time to tail flick, vehicle, before/after SA0.50.51.4-0.9-1.1-0.71.20.20.3-0.3-0.1
Delta time to tail flick, test, before/after SA1.21.13.51.20.71.3-0.40.2-1.2-0.1-1.9
Tibia length2.57.113.2-3.5-2.4-3.63.4-0.33.0-0.42.3
Ambulatory time before self-admin0.90.91.91.31.41.2-1.30.3-0.70.3-0.4
Ambulatory time after self-admin0.30.31.00.60.30.7-0.6-0.6-0.5-1.0-0.1
Bone: tissue strength1.71.73.0-0.61.4-1.1-0.81.71.41.61.3
Total heroin consumption3.23.76.82.61.92.6-2.3-0.7-2.4-0.4-1.2
Bone: trabecular number4.26.511.83.42.43.4-3.0-0.4-3.1-0.1-2.0
Bone: trabecular spacing3.03.96.7-2.4-1.4-2.62.10.92.60.82.0
Bone: trabecular thickness0.40.51.00.80.90.7-0.31.0-0.70.90.2
Bone: trabecular tissue density1.01.44.0-0.9-0.2-1.00.22.01.31.70.6
Water consumed over 24 hours0.10.10.6-0.00.1-0.10.8-0.30.2-0.40.1
Number of responses in last shaping day0.50.51.20.8-0.01.0-0.3-1.1-0.6-0.9-0.2