Hub : Genes

Ubr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio NM_001412818.1 0.02 0.02 7.0e-03 0.02 0.02 0.03 0.02 2.2e-03 2.4e-03 2.7e-04 3.8e-03
2 NAcc mRNA stability Ubr2 0.02 0.02 2.4e-03 0.02 0.02 0.01 0.02 2.4e-03 9.5e-04 6.9e-03 2.8e-03
3 IL isoform ratio XM_039083819.1 0.82 0.11 2.9e-03 0.12 0.11 0.13 0.1 8.2e-04 1.7e-03 4.9e-04 1.8e-03
4 PL mRNA stability Ubr2 0.03 0.02 1.7e-03 0.02 0 0 0.01 3.5e-03 8.2e-02 2.3e-01 5.3e-02
5 pVTA isoform ratio NM_001412818.1 0.71 0.18 1.6e-03 0.02 0.01 0.01 0.03 5.4e-02 1.3e-01 9.3e-02 1.9e-02
6 Adipose mRNA stability Ubr2 0.03 0.02 2.5e-03 0 0.01 0 0 9.4e-02 2.9e-02 1.1e-01 1.3e-01
7 Liver mRNA stability Ubr2 0.03 0.03 4.3e-03 0.02 0.01 0.03 0.02 4.3e-03 6.8e-03 7.0e-04 4.2e-03
8 Liver alternative TSS XM_039083819.1 0.02 0.02 6.0e-03 0 0 -0 0 3.0e-01 1.2e-01 5.3e-01 3.2e-01
9 NAcc alternative TSS XM_039083814.1 0.03 0.02 9.1e-03 0 0.01 -0 0 2.0e-01 2.1e-02 5.3e-01 2.1e-01
10 BLA mRNA stability Ubr2 0.09 0.06 4.8e-04 0.03 0.06 0.05 0.06 9.0e-03 3.4e-04 8.1e-04 6.0e-04
11 Liver isoform ratio XM_039083819.1 0.03 0.02 5.9e-03 0.01 0.01 0 0 4.5e-02 4.2e-02 1.2e-01 7.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.52.2-0.4-0.6-1.20.90.6-0.1-0.00.21.50.30.5
Area under the delay curve7.47.910.1-3.1-3.0-1.83.13.1-3.22.7-3.1-0.4-3.0-2.9
BMI with tail2.78.713.93.63.73.4-3.6-3.53.0-2.32.4-2.12.11.8
BMI without tail8.517.627.05.15.24.6-4.9-4.74.4-4.13.6-2.43.22.9
Body weight2.39.614.53.83.73.7-3.5-3.43.2-3.22.7-1.52.42.2
Weight adjusted by age0.50.63.11.80.61.3-0.7-0.70.4-0.50.2-0.50.20.1
Bone surface0.71.22.5-1.0-1.5-1.41.61.4-1.00.6-0.71.4-0.5-0.4
Bone volume0.30.51.2-0.6-0.9-1.01.10.9-0.50.3-0.31.1-0.2-0.1
Breakpoint value in progressive ratio session0.20.20.4-0.1-0.10.6-0.5-0.5-0.30.5-0.4-0.7-0.5-0.5
Number of licking bursts4.25.07.51.92.20.2-2.1-2.42.6-2.22.71.22.72.7
Context. condit. distance diff. score0.20.20.70.20.40.6-0.5-0.50.5-0.80.40.00.40.4
Locomotion velocity, session 10.60.73.10.50.71.5-0.8-0.50.10.0-0.3-1.8-0.5-0.6
Locomotion distance, session 12.02.54.52.01.82.1-1.9-1.71.5-1.81.1-1.01.00.9
Locomotion velocity, session 24.35.011.92.72.63.5-2.8-2.41.9-1.91.2-2.30.90.7
Locomotion distance, session 20.91.22.61.31.41.6-1.2-1.11.0-1.10.7-1.10.60.5
Locomotion velocity, session 30.60.73.10.50.61.6-0.6-0.30.0-0.0-0.3-1.8-0.5-0.6
Locomotion distance, session 31.21.32.2-0.8-1.00.20.91.0-1.31.3-1.4-1.0-1.5-1.5
Stereotopy head waving bouts, day 31.11.32.11.21.30.8-1.2-1.21.3-1.51.2-0.11.11.1
Stereotopy head waving duration, day 31.31.62.61.31.61.3-1.5-1.41.3-1.41.1-0.71.00.9
Locomotion velocity, session 70.50.52.7-0.10.31.1-0.20.1-0.20.6-0.6-1.7-0.7-0.8
Locomotion distance, session 70.30.41.8-0.10.20.8-0.10.2-0.30.7-0.5-1.3-0.7-0.7
Stereotopy head waving bouts, day 70.20.20.50.20.50.1-0.2-0.30.5-0.70.60.20.60.6
Stereotopy head waving duration, day 70.20.31.0-0.2-0.1-0.60.40.20.2-0.70.41.00.50.5
Locomotion velocity, session 80.50.62.10.80.81.5-0.9-0.70.6-0.90.4-0.80.30.2
Locomotion distance, session 80.71.02.01.01.21.4-1.1-1.01.1-1.30.8-0.70.70.7
Degree of sensitization distance0.90.91.80.81.31.0-1.1-1.01.1-0.80.9-0.80.70.7
Degree of sensitization stereotypy0.40.40.9-0.9-0.7-0.80.90.8-0.50.2-0.30.7-0.2-0.1
Conditioned locomotion2.42.84.4-1.7-1.5-0.11.31.6-1.91.8-2.0-1.2-2.1-2.1
Cocaine response after cond. corrected0.20.20.6-0.6-0.5-0.80.50.4-0.40.6-0.30.4-0.2-0.2
Cocaine response after cond. not corrected0.40.50.8-0.9-0.7-0.80.80.8-0.70.8-0.60.2-0.5-0.5
Cocaine response before conditioning0.10.20.80.10.10.60.10.2-0.20.2-0.4-0.9-0.4-0.5
Saline control response0.10.10.5-0.1-0.00.7-0.1-0.0-0.2-0.3-0.4-0.6-0.4-0.4
Bone: connectivity density0.71.25.3-0.6-0.9-1.91.10.7-0.20.00.32.30.60.7
Bone: cortical apparent density0.70.91.8-1.4-1.0-0.40.70.9-1.10.9-1.1-0.3-1.1-1.1
Bone: cortical area0.81.25.70.80.82.4-0.7-0.40.2-0.6-0.3-2.1-0.6-0.7
Bone: cortical porosity0.20.20.60.60.30.2-0.1-0.20.4-0.70.40.20.40.4
Bone: cortical porosity0.10.10.20.50.20.5-0.0-0.00.1-0.40.0-0.30.0-0.0
Bone: cortical thickness0.91.56.40.81.12.5-1.2-0.70.4-0.6-0.2-2.3-0.4-0.6
Bone: cortical thickness0.00.00.2-0.2-0.0-0.1-0.1-0.00.1-0.30.20.40.20.2
Bone: cortical tissue density0.60.81.7-1.3-1.0-0.50.70.8-1.00.9-1.0-0.2-1.0-0.9
Condit. Reinf. active minus inactive responses1.11.32.60.81.40.5-1.6-1.61.3-0.41.2-0.31.11.1
Condit. Reinf. active-inactive response ratio0.50.50.80.20.6-0.4-0.8-0.90.8-0.10.90.60.90.9
Condit. Reinf. active responses1.92.43.91.51.91.3-2.0-1.91.8-1.31.5-0.61.41.3
Condit. Reinf. inactive responses1.72.13.41.71.71.5-1.5-1.51.5-1.81.3-0.51.21.1
Incentive salience index mean1.31.63.21.31.61.6-1.8-1.61.3-0.70.9-1.30.70.6
Condit. Reinf. lever presses2.63.56.62.32.32.6-2.3-2.11.8-1.51.3-1.71.00.9
Condit. Reinf. active minus inactive responses0.30.41.30.20.2-0.60.0-0.20.5-0.50.71.10.80.9
Condit. Reinf. active-inactive response ratio1.61.73.31.01.0-0.4-0.8-1.11.5-1.11.71.41.81.8
Condit. Reinf. active responses0.00.10.20.30.0-0.20.20.10.1-0.20.20.50.30.3
Condit. Reinf. inactive responses0.30.40.90.1-0.30.70.40.5-0.60.3-0.7-1.0-0.8-0.9
Condit. Reinf. lever presses0.70.92.11.40.80.6-0.5-0.61.0-1.51.00.51.01.0
Condit. Reinf. lever reinforcers received0.00.10.20.3-0.0-0.10.30.20.1-0.30.20.50.20.3
Conditioned reinforcement - actives1.71.72.7-1.2-1.0-0.11.11.3-1.41.5-1.6-1.2-1.6-1.6
Conditioned reinforcement - inactives0.40.42.20.50.81.0-0.3-0.00.3-0.00.0-1.5-0.2-0.3
Conditioned locomotion0.00.00.3-0.50.0-0.3-0.00.1-0.10.0-0.1-0.3-0.1-0.1
Patch foraging indifference point 0 sec0.61.01.90.61.20.4-1.4-1.31.1-0.71.1-0.11.01.0
Patch foraging indifference point AUC0.60.74.1-0.30.81.2-0.7-0.30.10.6-0.3-2.0-0.5-0.6
Delay disc. indifference point, 0s delay2.02.26.4-2.5-1.2-2.21.31.1-1.12.4-0.90.5-0.8-0.7
Delay disc. indifference point, 16s delay9.49.613.4-2.9-3.6-1.73.63.5-3.72.8-3.5-0.3-3.4-3.3
Delay disc. indifference point, 2s delay3.13.48.3-2.9-1.8-2.01.51.4-1.92.3-1.8-0.1-1.7-1.6
Delay disc. indifference point, 24s delay0.60.51.2-0.4-1.1-0.10.80.8-1.00.4-0.90.4-0.8-0.7
Delay disc. indifference point, 4s delay4.64.88.2-2.0-1.8-0.21.92.0-2.52.3-2.7-1.9-2.8-2.9
Delay disc. indifference point, 8s delay4.74.96.6-2.2-2.3-0.92.42.4-2.62.2-2.6-0.6-2.5-2.5
Indifference point function ln k0.30.41.0-0.5-0.8-1.00.40.3-0.70.8-0.50.4-0.5-0.5
Indifference point function log k0.30.41.0-0.5-0.8-1.00.40.3-0.70.8-0.50.4-0.5-0.5
Patch foraging total patch changes 0 sec0.71.12.20.71.30.5-1.5-1.41.3-0.61.2-0.21.11.0
Patch foraging total patch changes 12 sec0.81.03.70.41.01.9-1.2-0.80.5-0.40.0-1.9-0.2-0.3
Patch foraging total patch changes 18 sec0.60.82.60.11.31.4-1.1-0.80.8-0.10.4-1.60.20.1
Patch foraging total patch changes 24 sec0.30.31.20.00.90.7-0.5-0.40.6-0.00.3-1.10.20.1
Patch foraging total patch changes 6 sec1.42.14.31.11.81.7-2.1-1.81.5-1.31.2-1.01.00.9
Patch foraging time to switch 0 sec2.03.16.8-1.8-2.6-2.02.21.9-1.80.2-1.22.3-1.0-0.8
Patch foraging water rate 0 sec1.72.713.11.31.82.8-1.4-0.90.60.6-0.2-3.6-0.6-0.8
Patch foraging water rate 12 sec3.04.58.02.72.82.6-2.6-2.22.1-1.41.5-2.21.21.0
Patch foraging water rate 18 sec0.81.02.01.41.21.4-1.3-1.10.8-0.40.5-1.20.40.3
Patch foraging water rate 24 sec1.11.52.91.71.61.3-1.6-1.31.2-0.20.8-1.30.70.5
Patch foraging water rate 6 sec0.50.73.50.30.41.1-0.10.2-0.20.9-0.6-1.9-0.8-0.9
Seeking ratio, delayed vs. immediate footshock1.31.53.3-1.8-1.6-1.71.21.1-1.21.2-0.91.0-0.8-0.7
Distance traveled before self-admin0.20.20.70.50.30.8-0.2-0.30.1-0.1-0.1-0.8-0.2-0.2
Distance traveled after self-admin2.42.74.51.52.11.3-2.0-2.01.9-1.11.7-0.61.61.5
Extensor digitorum longus weight0.10.30.90.60.61.0-0.6-0.50.3-0.70.2-0.70.10.0
Bone: elastic displacement0.20.20.4-0.5-0.6-0.00.50.6-0.50.2-0.50.1-0.5-0.5
Bone: elastic work0.10.10.40.20.10.5-0.1-0.10.2-0.60.20.20.20.3
Bone: endosteal estimation0.30.61.2-0.6-1.0-1.01.10.9-0.80.8-0.50.7-0.4-0.4
Bone: endosteal perimeter0.00.00.10.3-0.00.30.20.1-0.1-0.0-0.1-0.1-0.1-0.1
Epididymis fat weight2.25.29.73.12.31.9-2.2-2.32.4-3.02.30.22.22.1
Delta time in closed arm before/after self-admin0.50.40.7-0.10.4-0.3-0.6-0.70.7-0.80.80.70.80.8
Delta time in open arm before/after self-admin0.40.41.1-0.9-0.6-0.80.50.7-0.61.0-0.60.0-0.5-0.5
Diff in mean of infusions in LGA sessions0.30.41.60.20.61.0-0.6-0.40.20.6-0.1-1.3-0.2-0.3
Delay discount exponential model param7.27.610.03.03.01.5-3.1-3.13.2-2.53.10.53.03.0
Extinction: sum of active levers before priming0.10.10.5-0.70.1-0.5-0.4-0.40.10.70.1-0.00.10.1
Active lever presses in extinction session 60.50.51.8-0.40.20.8-0.6-0.4-0.30.9-0.6-1.3-0.7-0.7
Bone: final force0.30.51.90.70.71.4-0.7-0.60.6-0.80.3-0.80.20.2
Bone: final moment0.30.52.40.60.71.6-0.6-0.40.3-0.4-0.0-1.3-0.2-0.2
Food consumed during 24 hour testing period0.40.41.30.70.71.1-0.8-0.60.3-0.00.1-1.1-0.0-0.1
Glucose4.56.79.83.12.92.1-2.8-2.82.9-2.82.6-0.12.52.4
Heart weight1.31.82.9-1.0-1.4-0.21.61.7-1.61.2-1.6-0.4-1.6-1.5
Delay discount hyperbolic model param6.67.09.13.02.81.5-2.9-2.93.0-2.53.00.62.92.9
Intermittent access intake day 1-15 change0.40.41.40.30.11.1-0.10.1-0.2-0.1-0.5-1.2-0.6-0.7
Intermittent access intake escalation0.10.10.50.3-0.10.70.00.2-0.2-0.2-0.4-0.6-0.4-0.5
Intermittent access intake escalation 20.40.41.60.20.21.1-0.4-0.1-0.2-0.2-0.5-1.3-0.6-0.7
Intermitt. access day 1 inactive lever presses0.60.61.40.61.20.3-0.8-0.71.0-0.90.9-0.60.80.7
Intermitt. access day 15 inactive lever presses1.92.16.72.61.51.9-1.6-1.41.2-1.30.9-0.90.80.6
Intermitt. access escalation Index0.20.20.6-0.5-0.0-0.8-0.2-0.40.10.20.30.60.30.3
Intermittent access day 1 total infusions0.70.81.60.00.8-0.7-0.5-0.71.1-0.61.20.71.21.3
Intermittent access day 15 total infusions0.20.30.5-0.20.6-0.4-0.3-0.30.7-0.50.70.30.70.7
Intermittent access terminal intake (last 3 days)0.30.30.5-0.60.4-0.7-0.2-0.20.6-0.40.70.50.70.7
Intermittent access total infusions0.40.51.1-0.50.3-1.1-0.1-0.20.6-0.30.80.90.90.9
Intermittent access day 1 locomotion0.90.92.0-0.70.5-1.4-0.4-0.60.9-0.41.11.21.21.3
Intermittent access day 15 total locomotion0.30.31.10.10.60.2-1.0-1.00.6-0.40.5-0.10.50.5
Intermittent access total locomotion0.70.82.0-0.80.2-1.4-0.4-0.50.6-0.40.91.31.01.1
Intermittent access standard deviation1.92.04.6-1.1-1.9-1.22.22.0-1.50.5-1.11.2-1.0-0.8
Left kidney weight0.82.29.31.80.53.1-0.5-0.1-0.3-0.4-0.9-2.6-1.2-1.3
Right kidney weight0.71.96.31.00.02.3-0.20.3-0.80.3-1.3-2.5-1.5-1.7
Cocaine induced anxiety0.50.51.61.00.40.3-1.0-1.30.6-0.80.60.40.60.6
Post-drug Anxiety0.30.41.11.00.10.3-0.5-0.80.3-0.90.40.70.50.5
Baseline Anxiety0.30.31.1-0.4-0.6-0.10.91.0-0.50.3-0.50.0-0.5-0.4
Tail length1.54.78.22.72.42.8-2.1-2.02.2-2.91.8-0.81.61.5
Length with tail0.20.63.21.00.51.8-0.3-0.20.4-1.50.2-0.50.10.1
Length without tail1.83.86.4-2.0-2.5-1.02.42.5-2.31.5-2.00.6-1.9-1.8
Times rat made contact with spout4.75.47.32.62.61.1-2.5-2.62.7-2.22.60.52.62.5
Lifetime Intake0.30.31.4-0.9-0.2-1.20.50.4-0.00.30.20.70.20.3
Liver weight, left0.50.82.71.00.81.6-1.1-0.80.3-0.2-0.1-1.5-0.3-0.4
Liver weight, right0.61.12.91.61.01.7-0.9-0.80.8-1.40.6-0.60.50.4
Locomotor activity2.23.55.52.32.01.8-1.9-2.02.0-2.31.90.01.81.7
Locomotor testing distance2.13.56.42.21.91.8-1.9-2.01.9-2.51.80.11.71.7
Locomotor testing rearing2.13.25.12.12.32.2-2.1-2.01.8-1.61.4-1.31.21.1
Locomotion in novel chamber0.70.91.2-1.1-1.0-0.20.91.0-1.11.0-1.1-0.3-1.1-1.1
Locomotion in novel chamber post-restriction2.42.84.9-0.9-1.30.11.51.7-1.92.0-2.1-1.6-2.1-2.2
Fecal boli incidents, locomotor time 11.31.42.5-0.9-0.70.70.81.0-1.21.2-1.5-1.5-1.6-1.6
Change in fecal boli incidents, locomotor task0.20.20.4-0.2-0.20.1-0.00.2-0.40.6-0.5-0.6-0.6-0.6
Time >=10cm from walls, locomotor time 10.20.20.6-0.80.50.3-0.5-0.30.20.20.1-0.80.0-0.0
Bouts of movement, locomotor time 10.70.72.7-0.6-0.2-1.40.50.20.40.00.81.60.91.0
Total resting periods, locomotor time 10.80.92.0-0.30.4-1.3-0.1-0.30.8-0.31.21.41.21.3
Rest time, locomotor task time 11.01.12.6-1.6-0.9-1.61.00.9-0.91.6-0.70.2-0.7-0.6
Distance moved, locomotor task time 10.10.10.60.70.20.4-0.1-0.00.3-0.80.30.20.30.2
Vertical activity count, locomotor time 10.30.30.6-0.2-0.80.30.50.7-0.80.2-0.8-0.0-0.7-0.8
Time >=10cm from walls, locomotor time 20.60.62.00.80.71.4-1.1-0.80.3-0.20.0-1.2-0.1-0.2
Bouts of movement, locomotor time 20.70.83.11.80.61.2-0.2-0.50.6-1.40.60.00.50.5
Total resting periods, locomotor time 20.30.41.41.20.30.70.1-0.20.4-1.00.50.40.50.5
Rest time, locomotor task time 20.60.72.1-1.5-0.8-1.30.90.6-0.50.6-0.11.2-0.00.1
Distance moved, locomotor task time 20.70.81.61.31.20.6-0.9-0.91.1-0.81.0-0.20.90.8
Vertical activity count, locomotor time 20.30.40.70.4-0.30.70.30.4-0.60.6-0.7-0.7-0.8-0.8
Light reinforcement 11.12.13.71.51.91.8-1.8-1.51.5-1.21.2-1.21.00.9
Light reinforcement 22.33.15.02.21.91.1-1.2-1.32.0-2.12.10.52.02.0
Bone: marrow area0.30.71.3-0.7-1.1-0.81.21.0-0.90.8-0.70.6-0.6-0.5
Bone: maximum diameter0.40.72.90.60.41.7-0.4-0.2-0.1-0.1-0.5-1.7-0.6-0.7
Bone: maximum force0.00.10.30.20.10.4-0.0-0.10.3-0.60.30.20.30.3
Bone: maximum moment0.00.00.30.10.00.50.00.10.0-0.2-0.1-0.2-0.1-0.1
Mean time between licks in bursts1.31.86.4-1.4-1.4-2.51.61.2-0.71.0-0.22.00.00.2
Mean num. licks in bursts0.70.81.4-0.5-0.80.20.70.9-1.11.0-1.2-0.8-1.2-1.2
Cd content in liver1.01.11.5-1.1-1.1-0.71.21.2-1.21.2-1.1-0.2-1.1-1.1
Co content in liver0.10.20.5-0.30.2-0.7-0.3-0.40.30.40.40.30.40.4
Cu content in liver1.21.43.1-1.4-0.8-0.10.81.0-1.21.8-1.4-1.1-1.4-1.5
Fe content in liver0.40.51.0-0.6-0.80.11.01.0-0.80.1-0.8-0.2-0.8-0.8
K content in liver0.80.84.6-0.1-0.5-1.20.40.10.2-0.90.62.10.80.9
Mg content in liver1.11.12.2-1.2-1.5-0.41.11.1-1.30.5-1.20.2-1.2-1.1
Mn content in liver1.31.52.60.51.1-1.0-1.2-1.41.4-0.11.61.01.61.6
Na content in liver0.10.10.50.00.20.7-0.2-0.0-0.00.1-0.2-0.7-0.3-0.3
Rb content in liver5.16.49.1-2.7-3.0-1.32.83.0-2.92.3-2.8-0.0-2.7-2.6
Se content in liver0.10.10.20.10.40.2-0.4-0.40.20.10.1-0.50.00.0
Sr content in liver0.30.30.70.70.80.5-0.7-0.60.6-0.20.5-0.50.40.4
Zn content in liver5.25.88.6-2.4-2.4-0.52.12.4-2.82.5-2.9-1.3-2.9-2.9
Bone: minimum diameter0.20.31.30.70.61.2-0.5-0.40.3-0.50.1-1.0-0.0-0.1
Time in familiar zone, hab. session 10.90.83.70.60.61.8-0.5-0.2-0.0-0.3-0.4-1.9-0.6-0.7
Time in novel zone, hab. session 11.11.14.6-1.4-0.8-2.10.70.5-0.31.20.01.60.20.4
Total zone transitions, hab. session 13.24.56.62.52.52.3-2.6-2.42.2-2.21.9-1.01.71.5
Total locomotion distance, hab. session 12.94.27.02.52.62.6-2.6-2.42.0-1.41.5-1.81.21.0
Locomotion velocity, hab. session 12.73.87.32.42.42.7-2.5-2.31.8-1.31.3-1.91.00.8
Time in familiar zone, hab. session 21.51.53.5-1.5-1.5-1.31.91.7-1.20.3-0.81.0-0.7-0.6
Time in novel zone, hab. session 20.30.30.80.30.60.3-0.9-0.80.40.70.2-0.60.20.1
Total zone transitions, hab. session 23.84.97.82.42.11.0-2.2-2.42.4-2.82.41.02.42.4
Total locomotion distance, hab. session 22.93.85.22.22.21.1-2.2-2.32.2-2.02.10.22.02.0
Locomotion velocity, hab. session 22.53.44.72.22.01.0-2.0-2.12.0-1.92.00.31.91.8
Novel to familiar place preference ratio0.10.10.10.20.30.2-0.3-0.30.3-0.00.2-0.20.20.2
Novelty place preference0.00.00.1-0.10.10.2-0.1-0.0-0.00.1-0.1-0.3-0.1-0.1
Time in novel zone, NPP test0.00.00.1-0.30.0-0.1-0.00.0-0.00.4-0.1-0.2-0.1-0.1
Total zone transitions, NPP test5.78.212.33.53.23.0-3.1-3.13.0-3.42.6-0.92.42.2
Total locomotion distance, NPP test4.86.610.23.23.02.3-2.9-2.92.8-2.52.5-0.62.32.1
Locomotion velocity, NPP test5.57.712.43.53.12.7-3.1-3.13.0-3.12.6-0.62.42.3
Intraocular pressure1.01.54.2-1.9-1.1-2.11.01.0-0.91.6-0.60.7-0.5-0.4
Delta distance traveled before/after self-admin3.84.16.31.52.40.4-2.3-2.42.5-1.42.50.42.42.4
Delta ambulatory time before/after self-admin2.93.25.11.32.20.2-1.8-1.92.3-1.32.30.42.22.2
Parametrial fat weight5.09.713.13.63.63.0-3.4-3.43.4-3.63.0-0.72.82.6
Pavlov. Cond. lever latency1.72.16.8-1.6-1.7-2.61.71.3-0.90.7-0.32.3-0.10.1
Pavlov. Cond. magazine entry latency0.91.15.30.60.81.8-0.8-0.50.00.3-0.5-2.3-0.7-0.8
Pavlov. Cond. change in total contacts1.31.42.81.21.51.6-1.7-1.40.9-0.20.5-1.70.30.2
Pavlov. Cond. index score1.82.27.31.51.72.7-1.6-1.20.8-0.50.2-2.7-0.2-0.3
Pavlov. Cond. latency score1.51.97.91.11.32.7-1.3-0.80.4-0.2-0.2-2.8-0.5-0.7
Pavlov. Cond. lever contacts2.32.78.02.01.92.8-1.8-1.51.2-1.00.6-2.40.30.1
Pavlov. Cond. magazine entry number1.31.65.2-1.2-1.4-2.21.41.1-0.70.3-0.12.30.10.3
Pavlov. Cond. intertrial magazine entries0.60.71.7-1.3-1.0-1.30.80.7-0.81.0-0.60.7-0.5-0.4
Pavlov. Cond. lever-magazine prob. diff.1.62.07.01.31.62.5-1.5-1.10.7-0.20.1-2.6-0.2-0.4
Pavlov. Cond. response bias2.63.27.92.12.22.8-2.2-1.81.4-0.90.8-2.40.50.3
Pavlov. Cond. lever latency2.63.56.7-2.4-1.9-1.51.71.8-2.02.6-1.9-0.2-1.8-1.8
Pavlov. Cond. magazine entry latency1.31.52.21.31.41.1-1.2-1.31.4-1.51.3-0.21.21.1
Pavlov. Cond. change in total contacts2.23.05.42.11.81.3-1.6-1.71.9-2.31.90.21.81.7
Pavlov. Cond. index score3.74.87.42.62.42.0-2.2-2.22.4-2.72.2-0.32.01.9
Pavlov. Cond. latency score4.05.07.62.62.51.9-2.3-2.32.5-2.82.3-0.22.12.0
Pavlov. Cond. lever contacts2.83.88.02.72.01.9-1.8-1.82.0-2.81.8-0.01.71.7
Pavlov. Cond. magazine entry number0.60.71.8-1.0-0.9-1.10.70.7-0.91.3-0.70.3-0.6-0.6
Pavlov. Cond. intertrial magazine entries0.00.00.10.30.10.1-0.1-0.1-0.00.1-0.0-0.00.0-0.0
Pavlov. Cond. lever-magazine prob. diff.3.74.87.42.62.41.9-2.2-2.22.4-2.72.2-0.22.12.0
Pavlov. Cond. response bias1.11.54.31.71.11.4-0.9-0.91.2-2.11.10.11.01.0
Time in closed arm before self-admin0.30.41.5-0.4-0.4-1.20.40.10.00.00.31.20.40.5
Time in closed arm after self-admin1.01.03.6-0.30.0-1.60.0-0.30.6-0.71.01.91.21.3
Time in open arm before self-admin1.61.84.91.71.62.2-1.4-1.11.0-1.00.5-2.00.30.1
Time in open arm after self-admin0.40.42.10.20.71.1-0.5-0.10.20.3-0.1-1.4-0.3-0.3
Bone: periosteal estimation0.10.31.20.20.11.00.00.2-0.20.2-0.5-1.1-0.6-0.6
Bone: periosteal perimeter0.60.93.81.30.91.9-0.8-0.60.6-1.20.3-1.20.10.0
Bone: post-yield work0.10.20.60.20.0-0.5-0.0-0.20.3-0.30.50.80.50.6
Progressive ratio test 1 active lever presses1.21.22.60.21.1-0.6-0.5-0.71.4-0.91.60.91.61.6
Progressive ratio test 1 breakpoint0.80.81.7-0.21.0-0.7-0.5-0.61.1-0.61.30.61.31.3
Progressive ratio test 1 inactive lever presses0.20.20.8-0.10.90.2-0.3-0.20.7-0.30.6-0.70.40.4
Progressive ratio test 2 active lever presses0.40.41.10.21.10.4-0.7-0.60.8-0.30.7-0.70.60.6
Progressive ratio test 2 breakpoint0.70.81.90.41.40.5-1.1-0.91.1-0.40.9-0.80.80.7
Progressive ratio test 2 inactive lever presses0.20.20.50.20.70.2-0.5-0.30.5-0.30.4-0.60.30.2
Incentive Sensitization - Responses0.50.51.30.91.01.1-0.7-0.60.7-0.30.5-1.00.30.2
Incentive Sensitization - Breakpoint0.50.51.20.81.11.1-0.7-0.60.7-0.30.5-1.10.30.2
Sum of active levers in priming session hrs 5-62.01.93.7-0.9-0.90.20.81.0-1.51.7-1.8-1.6-1.8-1.9
Progressive ratio0.50.51.0-1.0-0.90.10.70.7-0.90.2-0.9-0.2-0.9-0.9
Food seeking constrained by brief footshock0.10.10.2-0.20.2-0.3-0.4-0.50.3-0.30.40.30.40.4
Seeking ratio, punishment vs. effort0.40.50.80.80.90.0-0.8-0.80.8-0.40.80.00.80.7
Retroperitoneal fat weight1.13.610.72.62.33.3-1.9-1.61.5-1.50.9-2.40.60.4
Reaction time number correct0.81.13.0-0.4-0.40.30.50.7-0.91.7-1.2-1.6-1.3-1.4
Reaction time mean minus median0.10.10.1-0.4-0.40.10.20.2-0.3-0.3-0.30.1-0.3-0.3
Reaction time mean minus median AUC0.20.30.8-0.5-0.7-0.80.80.6-0.40.0-0.20.9-0.10.0
Reaction time num false alarms0.50.61.6-1.3-1.0-0.90.80.8-0.90.6-0.70.4-0.7-0.6
Reaction time num false alarms AUC0.40.51.2-1.1-0.9-0.50.70.7-0.80.6-0.80.0-0.8-0.7
Reaction time trials correct on left0.81.13.0-0.4-0.40.30.50.7-0.91.7-1.2-1.6-1.3-1.4
Reaction time trials on left0.71.02.6-0.3-0.30.40.40.6-0.91.6-1.1-1.5-1.2-1.3
Reaction time mean0.81.14.7-0.3-0.3-1.40.40.00.5-1.10.92.21.11.2
Reaction time mean AUC1.01.45.8-0.2-0.2-1.40.3-0.20.6-1.31.12.41.31.4
Median of all reaction times0.91.35.1-0.1-0.1-1.40.3-0.10.7-1.31.12.31.31.4
Reaction time omissions0.60.81.21.10.90.8-0.9-1.00.9-1.10.90.20.90.9
Reaction time false alarm rate0.30.51.0-1.0-0.9-0.90.70.6-0.5-0.1-0.31.0-0.2-0.1
Reaction time premature initiation rate0.50.71.30.61.20.6-0.9-0.91.0-0.80.9-0.40.80.8
Reaction time premature initiations0.40.51.90.61.01.0-0.8-0.60.60.00.3-1.40.10.0
Std. dev. reaction times0.30.41.8-0.1-0.4-0.50.30.00.2-1.10.41.30.50.6
Reaction time trials completed0.71.02.6-0.3-0.30.40.40.6-0.91.6-1.1-1.5-1.2-1.3
Reaction time trials AUC0.60.92.6-0.3-0.20.40.30.5-0.71.6-1.0-1.6-1.1-1.2
Run reversals in cocaine runway, females0.60.62.50.80.81.6-0.7-0.40.4-0.30.0-1.4-0.1-0.2
Run reversals in cocaine runway, males0.00.00.1-0.10.2-0.2-0.0-0.00.00.3-0.0-0.4-0.0-0.1
Latency to leave start box in cocaine runway0.80.82.00.91.40.8-1.0-0.81.0-0.70.8-1.00.70.6
Latency to leave start box in cocaine runway, F0.10.10.30.40.4-0.20.30.10.4-0.20.50.10.50.5
Latency to leave start box in cocaine runway, M2.42.35.01.22.11.5-2.2-1.91.6-1.01.1-1.80.80.7
Std. dev. time between licks in bursts1.61.92.6-1.6-1.5-1.31.61.5-1.51.5-1.30.3-1.2-1.2
Total sessions with >9 infusions0.20.20.6-0.6-0.2-0.50.50.5-0.30.8-0.2-0.3-0.3-0.2
Short access day 1 total inactive lever presses0.40.41.50.50.10.80.40.6-0.30.4-0.5-1.2-0.6-0.7
Short access day 10 total inactive lever presses0.50.51.80.90.91.1-0.7-0.40.5-0.30.2-1.40.0-0.1
Short access day 1 total infusions0.60.71.4-0.6-0.7-0.41.21.1-0.81.0-0.8-0.3-0.8-0.8
Short access day 10 total infusions0.50.61.9-0.9-0.0-1.40.30.20.4-0.20.71.20.70.9
Short access total infusions0.60.72.4-1.4-0.7-1.60.90.9-0.40.7-0.20.8-0.1-0.0
Short access day 1 locomotion0.70.72.0-1.4-0.9-1.10.80.9-0.71.0-0.60.3-0.5-0.5
Short access day 10 total locomotion1.51.64.4-1.7-1.5-2.11.51.2-0.90.6-0.41.8-0.2-0.1
Short access total locomotion2.22.36.9-2.6-1.6-2.01.51.5-1.41.6-1.10.6-1.0-0.9
One hour access (0.3 mA shock)0.80.92.3-1.5-0.6-0.10.50.8-0.91.0-1.1-1.0-1.2-1.2
Compulsive drug intake0.30.30.8-0.5-0.20.3-0.10.2-0.50.7-0.6-0.9-0.7-0.7
One hour access (shock baseline)0.20.20.3-0.40.5-0.2-0.5-0.50.5-0.50.60.20.60.6
Social response proportion0.60.71.70.2-1.1-0.01.31.2-0.9-0.1-0.90.2-0.8-0.8
Social responses1.82.34.4-1.0-1.8-0.22.12.1-1.80.7-1.7-0.1-1.7-1.6
Social time3.34.48.0-0.9-1.50.91.82.2-2.31.7-2.6-2.3-2.8-2.8
Soleus weight0.41.12.81.51.11.7-1.1-0.90.8-1.40.6-0.80.40.4
Bone: stiffness0.00.00.1-0.1-0.1-0.10.30.2-0.0-0.10.00.20.00.1
Tibialis anterior weight0.20.60.91.00.80.4-0.8-0.90.9-0.90.80.10.80.8
Time to tail flick, vehicle, before self-admin0.40.41.2-0.4-0.60.21.10.9-0.70.4-0.7-0.3-0.7-0.7
Time to tail flick, vehicle, after self-admin1.11.22.6-0.4-1.6-1.11.51.4-1.1-0.6-0.81.4-0.6-0.5
Time to tail flick, test, before self-admin5.25.07.5-1.8-2.3-0.42.12.5-2.72.4-2.7-1.0-2.7-2.7
Time to tail flick, test, after self-admin0.60.61.4-0.5-0.8-0.01.01.2-0.80.7-0.8-0.1-0.8-0.8
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.0-0.7-0.40.50.6-0.5-0.5-0.30.7-0.2-0.2
Delta time to tail flick, test, before/after SA2.42.23.91.31.1-0.1-0.7-1.01.6-1.91.91.61.92.0
Tibia length1.33.76.52.42.62.5-2.3-2.11.9-1.21.4-2.01.10.9
Ambulatory time before self-admin0.40.41.1-0.0-0.20.70.20.2-0.50.5-0.7-1.1-0.8-0.9
Ambulatory time after self-admin2.22.44.21.32.11.1-1.9-2.01.9-1.11.6-0.61.51.4
Bone: tissue strength0.10.10.2-0.4-0.30.20.20.3-0.40.4-0.5-0.3-0.5-0.5
Total heroin consumption0.10.10.3-0.20.3-0.2-0.3-0.50.30.00.30.10.30.3
Bone: trabecular number0.20.41.0-0.4-0.8-0.61.00.9-0.50.0-0.30.8-0.3-0.2
Bone: trabecular spacing0.40.51.80.40.81.0-0.9-0.70.30.1-0.0-1.3-0.1-0.3
Bone: trabecular thickness0.60.71.8-0.6-0.9-1.31.20.9-0.50.3-0.21.3-0.00.1
Bone: trabecular tissue density0.91.33.5-1.0-0.4-0.00.30.6-1.01.9-1.2-1.7-1.3-1.4
Water consumed over 24 hours1.61.95.31.61.62.3-1.6-1.41.1-1.10.6-1.70.40.3
Number of responses in last shaping day0.10.10.6-0.20.30.3-0.5-0.30.10.3-0.1-0.7-0.2-0.2