Hub : Genes

Tyw5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	XM_006244910.4	0.02	0.01	5.9e-03	0	0	0	0	1.0e-01	7.1e-02	6.2e-02	1.1e-01
2	NAcc	alternative TSS	NM_001170473.1	0.02	0.01	2.3e-03	0	0.01	0.01	0	6.3e-02	2.0e-02	1.2e-02	4.6e-02
3	NAcc	alternative TSS	NM_001170473.1	0.02	0.01	8.1e-03	0	0	0.01	0	9.9e-02	5.7e-02	3.0e-02	5.3e-02
4	NAcc	alternative TSS	XM_006244910.4	0.02	0.01	5.2e-03	0.01	0.01	0	0	7.3e-03	3.6e-02	4.2e-02	4.4e-02
5	NAcc	gene expression	Tyw5	0.04	0.03	1.1e-04	0.01	0.01	0.01	0.01	1.3e-02	7.7e-03	6.9e-03	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.8	-0.9	0.7	0.5	-0.2	-0.1
Area under the delay curve	0.0	0.0	0.1	-0.2	0.2	0.0	0.2	-0.3
BMI with tail	7.5	26.3	29.3	5.4	-5.4	-5.3	4.9	4.7
BMI without tail	1.2	6.5	8.1	2.5	-2.5	-2.7	2.9	2.0
Body weight	0.0	0.2	0.3	-0.6	0.6	0.4	-0.2	-0.3
Weight adjusted by age	0.1	0.3	0.5	-0.7	0.6	0.6	-0.6	0.2
Bone surface	2.4	4.7	6.0	-2.4	2.4	2.1	-1.7	-2.1
Bone volume	1.1	2.1	3.1	-1.8	1.7	1.4	-1.1	-1.2
Breakpoint value in progressive ratio session	0.4	0.6	0.8	-0.8	0.8	0.9	-0.9	-0.5
Number of licking bursts	0.0	0.1	0.3	-0.3	0.2	0.4	-0.6	0.1
Context. condit. distance diff. score	0.2	0.2	0.3	0.4	-0.4	-0.5	0.6	0.4
Locomotion velocity, session 1	1.1	1.2	1.5	1.2	-1.2	-1.2	1.1	0.7
Locomotion distance, session 1	2.1	2.7	2.8	1.6	-1.7	-1.6	1.7	1.6
Locomotion velocity, session 2	0.7	0.8	1.2	0.9	-0.9	-1.0	1.1	0.5
Locomotion distance, session 2	2.5	3.5	4.8	1.9	-1.8	-2.1	2.2	1.0
Locomotion velocity, session 3	0.6	0.7	0.9	0.8	-0.8	-0.9	0.9	0.7
Locomotion distance, session 3	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.3
Stereotopy head waving bouts, day 3	0.2	0.3	0.4	0.6	-0.6	-0.5	0.3	0.6
Stereotopy head waving duration, day 3	1.3	1.6	1.8	1.2	-1.3	-1.3	1.3	1.3
Locomotion velocity, session 7	0.8	0.9	1.1	1.0	-1.0	-0.9	0.8	0.9
Locomotion distance, session 7	0.3	0.4	0.6	0.8	-0.7	-0.7	0.6	0.3
Stereotopy head waving bouts, day 7	0.3	0.4	0.7	-0.8	0.7	0.7	-0.4	-0.4
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.3	-0.4	-0.5	0.7	0.6
Locomotion velocity, session 8	0.1	0.1	0.3	0.2	-0.3	-0.4	0.6	0.3
Locomotion distance, session 8	0.5	0.7	0.9	0.8	-0.8	-0.9	1.0	0.5
Degree of sensitization distance	0.5	0.6	0.7	0.8	-0.8	-0.8	0.7	0.7
Degree of sensitization stereotypy	0.4	0.4	0.7	-0.8	0.8	0.5	-0.1	-0.6
Conditioned locomotion	0.6	0.7	1.8	-0.8	0.9	0.6	-0.2	-1.4
Cocaine response after cond. corrected	1.3	1.9	2.5	-1.6	1.6	1.3	-0.8	-1.6
Cocaine response after cond. not corrected	1.4	2.1	3.0	-1.7	1.7	1.5	-1.2	-1.0
Cocaine response before conditioning	0.4	0.5	2.0	0.1	-0.2	0.1	-0.4	1.4
Saline control response	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	0.4
Bone: connectivity density	0.1	0.1	0.3	-0.5	0.4	0.2	0.1	-0.0
Bone: cortical apparent density	1.1	1.7	3.0	1.7	-1.6	-1.1	0.5	1.1
Bone: cortical area	2.5	4.1	5.6	-1.8	1.9	2.0	-2.0	-2.4
Bone: cortical porosity	5.2	5.6	6.2	-2.5	2.5	2.5	-2.3	-2.1
Bone: cortical porosity	5.9	6.5	7.6	-2.8	2.7	2.7	-2.5	-2.1
Bone: cortical thickness	0.2	0.3	0.8	-0.0	0.1	0.4	-0.6	-0.9
Bone: cortical thickness	0.8	0.9	1.3	1.1	-1.1	-0.8	0.5	1.1
Bone: cortical tissue density	1.3	2.1	3.5	1.9	-1.8	-1.3	0.7	1.2
Condit. Reinf. active minus inactive responses	1.4	1.6	2.6	-1.3	1.2	1.5	-1.6	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	-0.7	0.6	0.7	-0.7	-0.2
Condit. Reinf. active responses	2.5	3.2	3.8	-1.9	1.8	1.9	-2.0	-1.3
Condit. Reinf. inactive responses	0.9	1.1	1.3	-1.0	1.1	1.0	-1.0	-1.1
Incentive salience index mean	2.8	3.6	4.8	-2.0	1.8	2.1	-2.2	-1.1
Condit. Reinf. lever presses	2.3	3.4	4.0	-1.9	1.9	2.0	-1.9	-1.5
Condit. Reinf. active minus inactive responses	1.6	2.5	3.1	-1.8	1.6	1.8	-1.7	-0.8
Condit. Reinf. active-inactive response ratio	1.0	1.7	3.0	-1.3	1.1	1.5	-1.7	-0.1
Condit. Reinf. active responses	1.5	2.2	2.8	-1.6	1.5	1.6	-1.7	-0.8
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.3	0.4	0.3	-0.3	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.8	0.1	-0.2	0.3	-0.8	0.9
Condit. Reinf. lever reinforcers received	1.6	2.2	3.0	-1.6	1.5	1.6	-1.7	-0.7
Conditioned reinforcement - actives	0.0	0.0	0.1	0.2	-0.2	-0.2	0.1	0.1
Conditioned reinforcement - inactives	0.7	2.0	2.9	-1.2	1.3	1.5	-1.7	-1.4
Conditioned locomotion	0.8	1.3	1.6	1.2	-1.1	-1.3	1.3	0.7
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.3	-0.3	-0.1	-0.1	0.4
Patch foraging indifference point AUC	0.4	0.9	1.2	-1.0	0.9	1.1	-1.1	-0.7
Delay disc. indifference point, 0s delay	3.8	4.2	5.1	2.0	-2.1	-2.2	2.3	1.7
Delay disc. indifference point, 16s delay	0.6	0.8	1.0	-1.0	1.0	0.9	-0.9	-0.7
Delay disc. indifference point, 2s delay	2.7	3.0	4.1	1.6	-1.6	-1.8	2.0	1.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	0.3	0.3	-0.3	-0.4
Delay disc. indifference point, 4s delay	1.2	1.2	1.9	1.0	-1.0	-1.2	1.4	0.8
Delay disc. indifference point, 8s delay	1.2	2.0	2.7	-1.5	1.6	1.3	-0.9	-1.6
Indifference point function ln k	0.1	0.3	0.6	0.5	-0.5	-0.6	0.8	0.2
Indifference point function log k	0.1	0.3	0.6	0.5	-0.5	-0.6	0.8	0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.6	0.5	-0.5	-0.2	-0.0	0.8
Patch foraging total patch changes 12 sec	0.3	0.4	1.2	-0.3	0.3	0.7	-1.1	0.1
Patch foraging total patch changes 18 sec	0.3	0.8	1.2	1.0	-1.1	-0.7	0.3	1.0
Patch foraging total patch changes 24 sec	0.2	0.6	1.4	-0.7	0.6	0.9	-1.2	-0.3
Patch foraging total patch changes 6 sec	0.2	0.3	1.0	0.3	-0.4	-0.3	0.2	1.0
Patch foraging time to switch 0 sec	0.2	0.6	0.7	0.8	-0.7	-0.9	0.6	0.8
Patch foraging water rate 0 sec	0.2	0.8	1.0	-1.0	0.9	0.9	-0.6	-1.0
Patch foraging water rate 12 sec	0.1	0.6	1.1	0.4	-0.6	-0.7	1.0	0.8
Patch foraging water rate 18 sec	0.0	0.1	0.1	-0.3	0.2	0.3	-0.3	0.3
Patch foraging water rate 24 sec	0.2	0.3	0.7	0.4	-0.4	-0.6	0.8	0.4
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.4	-0.4	-0.5	0.8	0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.7	-0.8	0.7	0.5	-0.2	-0.4
Distance traveled before self-admin	0.6	1.4	1.8	-1.3	1.3	1.2	-1.2	-0.8
Distance traveled after self-admin	0.2	0.4	0.5	-0.7	0.6	0.6	-0.5	-0.6
Extensor digitorum longus weight	1.6	6.5	8.2	2.9	-2.7	-2.7	2.4	1.9
Bone: elastic displacement	0.9	1.1	2.2	0.9	-1.1	-0.8	0.7	1.5
Bone: elastic work	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2	0.1
Bone: endosteal estimation	2.5	6.2	7.4	-2.7	2.7	2.6	-2.5	-2.0
Bone: endosteal perimeter	2.0	4.9	6.2	-2.5	2.5	2.2	-1.9	-2.0
Epididymis fat weight	0.1	0.7	1.8	-0.8	0.9	0.6	-0.3	-1.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2	-0.1
Delta time in open arm before/after self-admin	4.6	5.5	6.7	-2.6	2.5	2.5	-2.3	-1.7
Diff in mean of infusions in LGA sessions	0.1	0.2	1.1	-0.0	-0.1	-0.1	0.1	1.0
Delay discount exponential model param	0.0	0.1	0.1	0.3	-0.3	-0.1	-0.2	0.3
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	0.0
Active lever presses in extinction session 6	0.8	0.8	0.9	-0.8	0.9	0.8	-0.8	-1.0
Bone: final force	2.5	4.1	4.6	-2.0	2.1	2.0	-1.9	-2.1
Bone: final moment	1.3	2.1	2.2	-1.4	1.4	1.4	-1.5	-1.4
Food consumed during 24 hour testing period	1.2	2.3	2.7	1.6	-1.6	-1.5	1.4	1.5
Glucose	2.0	3.2	3.4	1.8	-1.8	-1.8	1.7	1.7
Heart weight	0.9	1.4	1.9	-1.4	1.3	1.2	-1.1	-0.8
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	-0.1	0.1	-0.4	0.2
Intermittent access intake day 1-15 change	0.2	1.3	2.3	1.1	-1.2	-1.0	0.6	1.5
Intermittent access intake escalation	0.4	1.9	3.4	1.4	-1.5	-1.2	0.8	1.8
Intermittent access intake escalation 2	0.2	0.3	1.1	0.3	-0.4	-0.3	0.0	1.0
Intermitt. access day 1 inactive lever presses	0.4	5.0	6.5	2.5	-2.5	-2.2	1.6	2.2
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.6	1.1	-1.1	-0.8	0.5	1.3
Intermitt. access escalation Index	0.1	0.2	0.8	-0.3	0.4	0.3	-0.2	-0.9
Intermittent access day 1 total infusions	0.1	0.3	0.7	-0.4	0.3	0.6	-0.9	0.1
Intermittent access day 15 total infusions	0.3	0.8	1.7	0.9	-1.0	-0.6	0.1	1.3
Intermittent access terminal intake (last 3 days)	0.9	1.5	3.1	1.2	-1.3	-0.9	0.6	1.8
Intermittent access total infusions	0.4	0.4	1.2	0.6	-0.7	-0.3	0.0	1.1
Intermittent access day 1 locomotion	0.0	0.1	0.3	-0.0	-0.0	0.3	-0.5	0.3
Intermittent access day 15 total locomotion	0.1	0.3	0.9	0.5	-0.6	-0.3	0.2	0.9
Intermittent access total locomotion	0.5	0.6	0.9	0.8	-0.8	-0.7	0.5	0.9
Intermittent access standard deviation	0.1	0.7	2.2	0.6	-0.8	-0.3	-0.1	1.5
Left kidney weight	0.0	0.3	0.8	0.4	-0.5	-0.5	0.4	0.9
Right kidney weight	0.1	0.3	1.0	0.3	-0.3	-0.7	1.0	0.4
Cocaine induced anxiety	0.0	0.1	0.1	0.2	-0.1	-0.3	0.4	-0.4
Post-drug Anxiety	0.3	0.4	0.9	0.5	-0.4	-0.7	1.0	0.1
Baseline Anxiety	0.0	0.1	0.2	-0.1	-0.1	-0.0	0.2	0.5
Tail length	4.9	26.3	30.8	-5.5	5.5	5.1	-4.4	-5.0
Length with tail	6.9	30.4	35.6	-6.0	5.9	5.6	-5.1	-4.8
Length without tail	1.5	7.8	9.5	-3.1	3.0	2.9	-2.8	-2.1
Times rat made contact with spout	2.3	2.6	3.1	1.8	-1.7	-1.7	1.6	1.4
Lifetime Intake	0.9	1.1	1.8	1.1	-1.2	-0.8	0.5	1.4
Liver weight, left	1.1	1.8	2.5	-1.5	1.6	1.2	-0.8	-1.6
Liver weight, right	0.1	0.2	0.3	-0.5	0.4	0.4	-0.4	0.4
Locomotor activity	0.3	0.5	0.7	0.8	-0.7	-0.9	0.8	0.5
Locomotor testing distance	0.9	2.2	2.5	1.5	-1.5	-1.5	1.2	1.6
Locomotor testing rearing	0.1	0.2	0.3	0.5	-0.5	-0.5	0.4	0.4
Locomotion in novel chamber	3.5	4.7	10.2	2.0	-2.2	-1.7	1.2	3.2
Locomotion in novel chamber post-restriction	0.1	0.3	0.8	-0.3	0.2	0.6	-0.9	0.6
Fecal boli incidents, locomotor time 1	0.2	0.6	0.9	-1.0	0.9	0.8	-0.7	-0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.3	-0.2	-0.3	0.4	-0.0
Time >=10cm from walls, locomotor time 1	0.6	0.8	1.1	-0.8	0.9	0.8	-0.9	-1.0
Bouts of movement, locomotor time 1	1.8	2.4	3.8	-1.5	1.4	1.8	-2.0	-0.9
Total resting periods, locomotor time 1	1.2	1.4	2.8	-0.9	0.9	1.4	-1.7	-0.6
Rest time, locomotor task time 1	1.1	1.7	2.7	-0.8	1.0	1.3	-1.6	-1.6
Distance moved, locomotor task time 1	0.1	0.3	0.5	-0.7	0.7	0.3	-0.1	-0.5
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.0	-0.0	-0.3	0.5	0.0
Time >=10cm from walls, locomotor time 2	0.3	0.8	1.4	0.8	-0.8	-1.1	1.2	0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.0	0.0	0.1	-0.0	0.0
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.2	0.1	0.3	-0.4	-0.1
Rest time, locomotor task time 2	0.6	1.1	1.8	-0.7	0.7	1.1	-1.4	-1.2
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.0	-0.0	-0.3	0.5	0.4
Vertical activity count, locomotor time 2	1.4	3.4	4.3	1.7	-1.7	-2.0	2.1	1.7
Light reinforcement 1	2.1	9.7	11.2	3.3	-3.2	-3.3	3.2	2.3
Light reinforcement 2	0.0	0.0	0.1	-0.1	0.1	-0.0	0.2	-0.2
Bone: marrow area	2.5	6.2	7.4	-2.7	2.7	2.6	-2.4	-2.0
Bone: maximum diameter	4.1	8.3	9.0	-2.9	2.9	2.9	-2.7	-3.0
Bone: maximum force	1.2	2.5	2.8	-1.6	1.7	1.5	-1.4	-1.5
Bone: maximum moment	0.4	0.7	0.8	-0.9	0.9	0.9	-0.9	-0.7
Mean time between licks in bursts	0.1	0.5	0.7	0.7	-0.6	-0.8	0.9	-0.3
Mean num. licks in bursts	0.7	1.8	2.5	1.4	-1.3	-1.5	1.6	0.7
Cd content in liver	0.1	0.1	0.3	0.1	-0.2	-0.3	0.5	0.0
Co content in liver	0.1	0.1	0.2	-0.1	0.1	0.3	-0.4	0.2
Cu content in liver	0.3	0.3	0.5	-0.6	0.6	0.5	-0.5	-0.7
Fe content in liver	0.2	0.2	0.3	-0.5	0.4	0.5	-0.6	0.4
K content in liver	1.3	1.3	1.6	-1.1	1.2	1.1	-1.1	-1.3
Mg content in liver	0.3	0.3	0.4	-0.6	0.6	0.6	-0.6	-0.4
Mn content in liver	0.6	0.7	1.0	1.0	-1.0	-0.7	0.4	0.8
Na content in liver	2.2	2.4	2.6	-1.5	1.6	1.6	-1.6	-1.5
Rb content in liver	0.1	0.1	0.3	-0.4	0.4	0.1	0.2	-0.6
Se content in liver	0.1	0.1	0.1	-0.3	0.3	0.3	-0.2	-0.4
Sr content in liver	0.1	0.1	0.4	-0.1	0.2	0.2	-0.3	-0.7
Zn content in liver	0.1	0.1	0.3	-0.1	0.2	0.1	-0.0	-0.5
Bone: minimum diameter	2.4	4.5	4.8	-2.0	2.1	2.2	-2.2	-2.2
Time in familiar zone, hab. session 1	0.1	0.2	0.6	-0.1	-0.1	-0.1	0.4	0.8
Time in novel zone, hab. session 1	0.2	0.2	0.7	-0.1	0.3	0.3	-0.5	-0.8
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.3	0.3	0.2	-0.1	-0.1
Total locomotion distance, hab. session 1	0.7	1.0	1.3	-1.1	1.0	1.1	-1.2	-0.4
Locomotion velocity, hab. session 1	0.7	1.0	1.3	-1.0	1.0	1.1	-1.1	-0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.8	0.4	-0.4	-0.1	-0.4	0.9
Time in novel zone, hab. session 2	0.3	0.3	0.8	0.5	-0.4	-0.7	0.9	-0.1
Total zone transitions, hab. session 2	2.1	2.7	3.1	1.6	-1.6	-1.8	1.7	1.4
Total locomotion distance, hab. session 2	1.7	2.2	2.7	1.5	-1.5	-1.6	1.7	1.2
Locomotion velocity, hab. session 2	1.4	1.8	2.4	1.3	-1.3	-1.4	1.5	1.0
Novel to familiar place preference ratio	0.5	0.7	1.0	0.8	-0.7	-0.9	1.0	0.6
Novelty place preference	0.5	0.7	0.9	0.8	-0.7	-0.9	0.9	0.7
Time in novel zone, NPP test	0.8	1.0	1.2	0.9	-0.9	-1.1	1.1	0.9
Total zone transitions, NPP test	0.1	0.1	0.2	0.3	-0.3	-0.3	0.3	0.4
Total locomotion distance, NPP test	0.6	0.8	1.7	0.8	-1.0	-0.7	0.6	1.3
Locomotion velocity, NPP test	0.6	0.8	1.5	0.9	-1.0	-0.7	0.5	1.2
Intraocular pressure	2.8	4.6	5.3	2.3	-2.3	-2.1	1.8	2.2
Delta distance traveled before/after self-admin	0.4	0.4	0.5	0.7	-0.7	-0.7	0.7	0.4
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.5	-0.4	-0.4	0.4	-0.2
Parametrial fat weight	0.2	0.5	0.7	0.9	-0.7	-0.8	0.8	-0.1
Pavlov. Cond. lever latency	0.8	1.0	1.5	1.2	-1.1	-1.1	1.0	0.5
Pavlov. Cond. magazine entry latency	1.0	1.3	2.0	-1.2	1.0	1.3	-1.4	-0.3
Pavlov. Cond. change in total contacts	0.6	0.6	0.9	-0.9	0.8	0.9	-0.8	-0.1
Pavlov. Cond. index score	1.6	2.0	2.7	-1.5	1.4	1.6	-1.6	-0.6
Pavlov. Cond. latency score	1.5	2.0	2.6	-1.6	1.4	1.6	-1.6	-0.5
Pavlov. Cond. lever contacts	0.6	0.7	0.9	-1.0	0.8	1.0	-0.9	-0.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.6	1.2	-1.1	-1.2	1.2	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	-0.7	0.7	0.5	-0.3	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	2.5	-1.4	1.2	1.5	-1.6	-0.5
Pavlov. Cond. response bias	1.7	2.1	2.8	-1.6	1.4	1.7	-1.7	-0.7
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.1	0.1	-0.4	0.9	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.0	-0.1	0.3	-0.5	0.3
Pavlov. Cond. change in total contacts	1.7	4.1	6.3	-1.9	1.8	2.3	-2.5	-1.5
Pavlov. Cond. index score	0.5	0.8	2.2	-0.7	0.6	1.1	-1.5	-0.3
Pavlov. Cond. latency score	0.5	0.8	2.0	-0.6	0.6	1.1	-1.4	-0.3
Pavlov. Cond. lever contacts	0.3	0.5	1.6	-0.3	0.2	0.7	-1.3	0.4
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.5	-0.5	-0.8	1.0	0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.1	0.8	-0.8	-1.0	1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	2.4	-0.7	0.7	1.2	-1.5	-0.4
Pavlov. Cond. response bias	0.3	0.4	1.3	-0.3	0.2	0.7	-1.1	0.3
Time in closed arm before self-admin	1.5	2.6	3.0	-1.7	1.6	1.7	-1.7	-1.2
Time in closed arm after self-admin	0.4	0.4	0.5	-0.7	0.7	0.7	-0.7	-0.4
Time in open arm before self-admin	4.2	5.1	6.7	2.6	-2.4	-2.4	2.2	1.5
Time in open arm after self-admin	1.2	1.3	1.6	-1.2	1.1	1.3	-1.3	-0.7
Bone: periosteal estimation	3.7	8.8	9.5	-3.0	3.1	3.0	-2.9	-2.8
Bone: periosteal perimeter	2.2	4.4	4.8	-2.2	2.2	2.1	-1.9	-2.0
Bone: post-yield work	0.3	0.4	0.8	0.6	-0.6	-0.6	0.6	0.9
Progressive ratio test 1 active lever presses	0.3	0.5	1.3	0.7	-0.8	-0.3	-0.1	1.2
Progressive ratio test 1 breakpoint	0.2	0.4	1.1	0.6	-0.7	-0.2	-0.1	1.0
Progressive ratio test 1 inactive lever presses	2.0	5.2	6.8	2.6	-2.6	-2.2	1.7	2.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.0	-0.1	0.3	-0.6	0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.1	-0.2	0.2	-0.5	0.5
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.7	0.8	-0.8	-0.4	0.0	0.8
Incentive Sensitization - Responses	0.5	1.4	1.7	-1.1	1.1	1.3	-1.3	-1.1
Incentive Sensitization - Breakpoint	0.5	1.2	1.4	-1.0	1.1	1.2	-1.2	-1.1
Sum of active levers in priming session hrs 5-6	1.8	1.7	3.2	-1.2	1.3	1.1	-1.0	-1.8
Progressive ratio	0.0	0.0	0.2	0.1	-0.1	0.0	-0.2	-0.4
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	0.2	0.3	-0.3	0.4
Seeking ratio, punishment vs. effort	0.1	0.3	0.7	-0.8	0.7	0.5	-0.1	0.0
Retroperitoneal fat weight	0.2	0.8	1.7	0.9	-0.8	-1.0	1.3	-0.1
Reaction time number correct	0.5	1.8	2.6	1.2	-1.3	-1.3	1.2	1.6
Reaction time mean minus median	0.0	0.0	0.0	-0.1	0.0	0.0	0.2	-0.1
Reaction time mean minus median AUC	0.0	0.1	0.2	0.1	-0.2	-0.1	0.0	0.5
Reaction time num false alarms	0.9	1.6	2.1	1.3	-1.3	-1.4	1.4	0.7
Reaction time num false alarms AUC	0.9	2.0	2.5	1.5	-1.4	-1.6	1.6	0.8
Reaction time trials correct on left	0.5	1.8	2.6	1.2	-1.3	-1.3	1.2	1.6
Reaction time trials on left	0.5	1.7	2.5	1.2	-1.3	-1.3	1.2	1.6
Reaction time mean	2.5	5.5	7.1	-2.3	2.4	2.3	-2.1	-2.7
Reaction time mean AUC	1.8	4.3	5.7	-2.0	2.0	2.0	-1.8	-2.4
Median of all reaction times	5.7	9.0	11.2	-2.9	3.0	3.0	-2.7	-3.3
Reaction time omissions	0.0	0.0	0.0	-0.2	0.2	0.0	0.0	-0.2
Reaction time false alarm rate	0.2	0.3	0.5	0.6	-0.4	-0.6	0.7	-0.2
Reaction time premature initiation rate	0.2	0.2	0.8	0.2	-0.4	0.1	-0.4	0.9
Reaction time premature initiations	0.4	1.2	3.0	1.0	-1.1	-0.7	0.3	1.7
Std. dev. reaction times	0.3	1.1	1.3	-1.1	1.1	1.0	-0.8	-1.0
Reaction time trials completed	0.5	1.7	2.5	1.2	-1.3	-1.3	1.2	1.6
Reaction time trials AUC	0.4	1.4	2.0	1.1	-1.1	-1.1	1.0	1.4
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.0	0.0	-0.1	0.2	-0.0
Run reversals in cocaine runway, males	0.4	0.4	0.9	-0.5	0.5	0.7	-0.9	-0.0
Latency to leave start box in cocaine runway	3.9	5.4	6.4	2.5	-2.5	-2.4	2.2	1.9
Latency to leave start box in cocaine runway, F	2.8	3.5	4.4	2.1	-2.0	-2.0	1.9	1.1
Latency to leave start box in cocaine runway, M	3.3	3.2	4.9	1.7	-1.8	-1.6	1.4	2.2
Std. dev. time between licks in bursts	0.7	1.3	1.8	1.3	-1.3	-1.2	1.0	0.9
Total sessions with >9 infusions	2.0	2.5	3.2	1.7	-1.8	-1.4	1.1	1.7
Short access day 1 total inactive lever presses	0.2	0.4	0.5	0.7	-0.7	-0.7	0.7	0.3
Short access day 10 total inactive lever presses	0.0	0.3	0.5	0.7	-0.6	-0.6	0.4	0.4
Short access day 1 total infusions	0.7	1.3	1.8	1.3	-1.3	-1.1	0.8	1.2
Short access day 10 total infusions	0.6	1.1	1.6	1.1	-1.2	-0.9	0.5	1.3
Short access total infusions	1.2	1.8	2.2	1.5	-1.5	-1.2	1.0	1.4
Short access day 1 locomotion	0.3	0.5	0.9	0.8	-0.9	-0.4	-0.1	1.0
Short access day 10 total locomotion	0.2	1.0	1.4	1.1	-1.1	-0.9	0.7	1.2
Short access total locomotion	1.6	2.4	3.0	1.7	-1.7	-1.6	1.3	1.4
One hour access (0.3 mA shock)	0.2	0.3	0.8	-0.3	0.2	0.6	-0.9	0.3
Compulsive drug intake	0.1	0.2	0.2	0.5	-0.4	-0.4	0.4	0.1
One hour access (shock baseline)	0.0	0.1	0.3	-0.0	-0.1	0.2	-0.4	0.6
Social response proportion	0.7	0.9	1.3	-1.1	1.1	0.9	-0.6	-0.9
Social responses	1.3	1.7	2.1	-1.4	1.4	1.2	-1.1	-1.4
Social time	0.5	0.8	1.0	-1.0	1.0	0.9	-0.8	-0.9
Soleus weight	0.2	0.6	0.9	0.6	-0.6	-0.9	1.0	0.7
Bone: stiffness	3.4	6.2	7.2	-2.6	2.7	2.4	-2.1	-2.6
Tibialis anterior weight	0.0	0.1	0.2	0.5	-0.4	-0.4	0.2	0.3
Time to tail flick, vehicle, before self-admin	0.4	0.5	0.7	-0.6	0.6	0.8	-0.9	-0.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.4	-0.1	0.2	0.2	-0.3	-0.6
Time to tail flick, test, after self-admin	1.6	1.7	3.5	1.2	-1.3	-1.1	0.9	1.9
Delta time to tail flick, vehicle, before/after SA	1.6	1.7	1.9	1.2	-1.3	-1.3	1.4	1.2
Delta time to tail flick, test, before/after SA	1.6	2.0	4.8	1.1	-1.3	-1.1	0.9	2.2
Tibia length	5.1	14.1	15.7	-4.0	4.0	3.8	-3.4	-3.7
Ambulatory time before self-admin	0.1	0.3	0.5	-0.7	0.7	0.5	-0.3	-0.4
Ambulatory time after self-admin	0.1	0.1	0.4	-0.3	0.3	0.2	-0.0	-0.6
Bone: tissue strength	0.0	0.0	0.1	0.0	-0.1	-0.2	0.4	0.2
Total heroin consumption	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	-0.7
Bone: trabecular number	0.2	0.4	0.9	-1.0	0.9	0.6	-0.3	-0.3
Bone: trabecular spacing	0.1	0.1	0.3	-0.1	0.2	0.2	-0.3	-0.6
Bone: trabecular thickness	0.1	0.1	0.2	0.1	-0.2	-0.3	0.4	0.5
Bone: trabecular tissue density	0.9	1.6	3.0	-0.9	1.0	1.4	-1.7	-1.2
Water consumed over 24 hours	2.4	4.6	5.6	2.2	-2.3	-2.0	1.7	2.4
Number of responses in last shaping day	0.0	0.0	0.1	0.0	-0.1	0.1	-0.3	0.3