Hub : Genes

Tymp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr7_120440624_120440704 0.02 0.01 4.4e-03 0.01 0.01 0.01 0.01 2.1e-02 7.1e-03 1.6e-02 7.0e-02
2 Liver intron excision ratio chr7_120441441_120441793 0.03 0.02 6.1e-04 0.03 0.03 0.03 0.03 9.9e-05 6.6e-04 4.8e-04 2.2e-04
3 Liver intron excision ratio chr7_120441911_120442016 0.04 0.03 5.0e-05 0.04 0.03 0.04 0.04 8.4e-06 9.9e-05 5.8e-05 4.1e-05
4 Liver alternative TSS XM_008765734.3 0.09 0.06 6.4e-09 0.08 0.08 0.08 0.08 3.1e-09 6.6e-09 3.6e-09 4.0e-09
5 Liver alternative TSS NM_001012122.2 0.07 0.04 5.5e-07 0.06 0.06 0.06 0.06 1.1e-07 6.5e-07 2.7e-07 4.4e-07
6 Liver isoform ratio XM_008765734.3 0.07 0.04 2.2e-08 0.07 0.07 0.06 0.07 3.2e-08 7.4e-08 3.0e-07 8.8e-08
7 Brain mRNA stability Tymp 0.03 0.02 9.3e-04 0.05 0.02 0.01 0.04 4.1e-05 8.3e-03 1.9e-02 1.8e-04
8 Liver mRNA stability Tymp 0.09 0.05 1.2e-12 0.09 0.09 0.1 0.09 1.0e-09 4.2e-10 1.0e-10 1.6e-10
9 Liver gene expression Tymp 0.31 0.1 0.0e+00 0.21 0.22 0.22 0.23 2.9e-23 2.9e-24 1.4e-24 3.9e-25
10 Liver isoform ratio XM_039079315.1 0.21 0.09 0.0e+00 0.16 0.19 0.19 0.19 7.3e-17 4.6e-21 4.3e-21 5.9e-21
11 pVTA isoform ratio XM_039079311.1 0.24 0.13 6.6e-04 0.08 0.08 0.08 0.07 2.9e-04 3.3e-04 2.7e-04 5.5e-04
12 pVTA isoform ratio XM_008765734.3 0.24 0.13 4.0e-04 0.07 0.07 0.08 0.06 4.2e-04 4.3e-04 3.0e-04 1.9e-03
13 Liver isoform ratio NM_001012122.2 0.08 0.06 5.9e-03 0.01 0.01 0.01 0.01 6.9e-02 7.2e-03 9.7e-03 2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.71.22.31.5-1.41.40.9-0.91.01.3-1.31.2-1.10.3-0.3-0.8
Area under the delay curve1.92.03.41.1-1.41.41.4-1.41.21.1-1.01.3-1.71.7-1.8-1.5
BMI with tail3.611.718.5-4.04.1-4.1-4.14.1-4.3-3.54.1-3.72.70.10.9-0.3
BMI without tail2.75.69.6-2.72.6-2.6-2.92.9-3.1-2.12.9-2.72.1-0.61.30.2
Body weight1.77.110.3-3.13.2-3.2-3.13.1-3.2-3.23.0-2.82.0-0.21.0-0.5
Weight adjusted by age2.93.35.6-2.32.1-2.1-2.12.1-2.2-2.42.0-1.81.20.30.1-0.6
Bone surface1.01.83.51.4-1.41.41.0-1.01.01.2-1.41.4-1.71.3-1.3-1.9
Bone volume1.22.12.91.7-1.51.51.3-1.31.41.5-1.61.5-1.71.1-1.1-1.5
Breakpoint value in progressive ratio session0.80.92.2-1.11.0-1.0-1.01.0-1.2-1.51.0-0.90.7-0.30.5-0.1
Number of licking bursts0.00.00.10.1-0.10.1-0.10.1-0.10.00.1-0.10.20.0-0.00.4
Context. condit. distance diff. score1.82.23.4-1.61.6-1.6-1.41.4-1.5-1.51.8-1.71.6-0.91.11.0
Locomotion velocity, session 10.20.20.5-0.40.3-0.3-0.40.4-0.6-0.40.7-0.50.20.4-0.2-0.2
Locomotion distance, session 12.12.73.71.6-1.81.81.7-1.71.91.7-1.51.5-1.81.5-1.6-0.9
Locomotion velocity, session 20.60.71.2-0.80.9-0.9-1.11.1-1.1-0.71.1-1.00.60.10.2-0.2
Locomotion distance, session 20.81.21.81.1-1.31.31.2-1.21.31.1-1.11.1-1.20.5-0.6-0.7
Locomotion velocity, session 31.31.55.2-0.60.4-0.4-0.70.7-0.6-0.40.9-1.01.4-2.32.11.8
Locomotion distance, session 30.10.10.40.4-0.10.10.1-0.10.20.6-0.10.10.1-0.40.30.6
Stereotopy head waving bouts, day 32.12.43.51.9-1.71.71.5-1.51.41.7-1.81.8-1.61.2-1.2-1.1
Stereotopy head waving duration, day 30.60.71.31.1-1.01.00.9-0.90.91.0-1.11.0-0.70.2-0.3-0.1
Locomotion velocity, session 71.01.12.9-0.51.5-1.5-0.70.7-0.8-0.20.7-0.81.3-1.31.21.7
Locomotion distance, session 70.30.41.0-0.61.0-1.0-0.40.4-0.4-0.30.7-0.60.7-0.30.30.9
Stereotopy head waving bouts, day 70.30.31.00.6-1.01.00.3-0.30.30.5-0.60.6-0.3-0.60.5-0.3
Stereotopy head waving duration, day 70.70.81.51.2-1.21.20.6-0.60.81.1-1.00.9-0.4-1.00.80.2
Locomotion velocity, session 81.51.82.8-0.81.3-1.3-1.51.5-1.5-0.81.2-1.31.5-1.51.70.8
Locomotion distance, session 80.50.71.4-1.10.8-0.8-1.01.0-0.8-1.01.2-1.00.6-0.10.4-0.4
Degree of sensitization distance1.01.01.9-1.31.3-1.3-1.11.1-1.2-1.41.1-0.90.60.3-0.1-0.4
Degree of sensitization stereotypy0.30.31.90.2-0.50.5-0.10.1-0.00.1-0.10.00.3-1.41.30.4
Conditioned locomotion0.50.61.1-0.70.8-0.8-0.90.9-0.7-0.61.0-1.00.8-0.50.60.3
Cocaine response after cond. corrected1.31.52.2-1.31.3-1.3-1.51.5-1.5-1.21.4-1.41.2-0.60.80.4
Cocaine response after cond. not corrected3.33.65.1-2.02.0-2.0-2.32.3-2.2-1.92.2-2.21.9-1.01.20.7
Cocaine response before conditioning0.91.11.6-1.21.2-1.2-1.31.3-1.2-1.11.3-1.21.1-0.10.20.3
Saline control response0.91.21.7-1.11.1-1.1-1.31.3-1.3-1.21.1-0.90.31.1-0.8-1.2
Bone: connectivity density0.40.71.51.2-1.11.10.5-0.50.71.1-0.90.8-0.7-0.0-0.0-0.5
Bone: cortical apparent density1.82.43.91.9-1.71.71.9-1.92.01.9-1.71.6-1.10.0-0.30.5
Bone: cortical area0.40.52.3-0.30.7-0.7-0.20.20.0-0.30.1-0.1-0.41.5-1.4-1.1
Bone: cortical porosity0.40.52.2-0.30.3-0.3-0.40.4-0.5-0.50.2-0.0-0.41.3-1.0-1.5
Bone: cortical porosity0.80.92.7-0.90.6-0.6-0.90.9-0.9-1.10.7-0.4-0.21.3-1.0-1.6
Bone: cortical thickness0.10.20.70.10.2-0.20.5-0.50.70.2-0.30.3-0.40.8-0.9-0.2
Bone: cortical thickness0.30.31.1-0.41.0-1.00.0-0.00.1-0.20.5-0.50.50.4-0.50.9
Bone: cortical tissue density1.62.23.51.8-1.61.61.8-1.81.91.8-1.71.5-1.0-0.0-0.30.5
Condit. Reinf. active minus inactive responses0.80.91.8-0.61.4-1.4-1.31.3-1.1-0.61.0-0.90.60.7-0.3-0.5
Condit. Reinf. active-inactive response ratio0.10.10.20.00.4-0.4-0.50.5-0.40.00.4-0.40.30.20.0-0.1
Condit. Reinf. active responses1.41.73.1-1.11.7-1.7-1.71.7-1.5-1.01.4-1.41.00.4-0.0-0.4
Condit. Reinf. inactive responses1.01.22.0-1.21.4-1.4-1.31.3-1.3-1.11.3-1.20.80.4-0.1-0.3
Incentive salience index mean1.31.52.8-1.01.7-1.7-1.71.7-1.5-1.01.2-1.10.60.8-0.4-0.9
Condit. Reinf. lever presses1.11.52.6-1.21.6-1.6-1.61.6-1.5-1.21.2-1.10.70.6-0.2-0.9
Condit. Reinf. active minus inactive responses0.81.02.50.7-0.10.10.7-0.70.70.6-1.01.1-1.21.6-1.5-1.5
Condit. Reinf. active-inactive response ratio0.30.30.70.50.1-0.10.5-0.50.40.5-0.70.7-0.50.8-0.8-0.4
Condit. Reinf. active responses0.60.83.4-0.00.6-0.60.1-0.1-0.0-0.0-0.10.3-0.71.9-1.6-1.5
Condit. Reinf. inactive responses0.50.71.4-0.90.9-0.9-0.60.6-0.6-0.80.9-0.80.11.2-0.9-0.7
Condit. Reinf. lever presses0.70.91.6-0.91.3-1.3-1.01.0-1.0-1.00.8-0.70.21.0-0.6-1.0
Condit. Reinf. lever reinforcers received0.60.83.60.00.5-0.50.2-0.20.10.0-0.30.5-0.81.9-1.7-1.6
Conditioned reinforcement - actives0.30.30.8-0.60.7-0.7-0.60.6-0.6-0.90.5-0.50.30.2-0.2-0.3
Conditioned reinforcement - inactives0.50.60.9-0.80.8-0.8-0.80.8-0.8-1.00.8-0.80.8-0.60.70.5
Conditioned locomotion2.63.14.9-2.22.1-2.1-2.12.1-2.1-2.22.0-1.91.40.10.1-0.1
Patch foraging indifference point 0 sec0.20.30.7-0.70.8-0.8-0.60.6-0.6-0.50.6-0.50.5-0.10.1-0.0
Patch foraging indifference point AUC1.71.97.80.9-1.01.00.7-0.70.80.5-1.01.2-1.92.0-1.7-2.8
Delay disc. indifference point, 0s delay0.70.73.9-0.00.2-0.2-0.20.2-0.30.3-0.00.3-0.81.7-1.4-2.0
Delay disc. indifference point, 16s delay0.60.61.80.6-0.70.70.6-0.60.50.3-0.50.7-1.01.1-1.1-1.3
Delay disc. indifference point, 2s delay5.35.913.11.8-1.91.91.9-1.91.91.7-1.92.2-2.93.5-3.6-3.1
Delay disc. indifference point, 24s delay0.50.41.7-0.60.6-0.6-0.60.6-0.7-1.30.9-0.80.50.2-0.10.2
Delay disc. indifference point, 4s delay1.61.72.70.8-1.31.31.3-1.31.01.2-0.91.2-1.61.5-1.5-1.6
Delay disc. indifference point, 8s delay1.41.42.11.0-1.51.51.5-1.51.30.8-1.01.2-1.30.9-1.1-0.6
Indifference point function ln k2.33.24.6-2.12.1-2.1-1.81.8-1.7-1.51.9-1.92.0-1.31.31.4
Indifference point function log k2.33.24.6-2.12.1-2.1-1.81.8-1.7-1.51.9-1.92.0-1.31.31.4
Patch foraging total patch changes 0 sec0.10.10.3-0.40.5-0.5-0.40.4-0.4-0.30.3-0.30.3-0.20.10.1
Patch foraging total patch changes 12 sec0.40.52.50.3-0.10.10.1-0.10.30.4-0.40.5-0.81.2-1.3-1.6
Patch foraging total patch changes 18 sec2.02.53.51.7-1.31.31.5-1.51.51.6-1.71.8-1.91.6-1.7-1.7
Patch foraging total patch changes 24 sec0.60.81.41.2-0.50.50.7-0.70.81.1-1.11.0-0.90.8-0.9-0.7
Patch foraging total patch changes 6 sec0.30.52.90.1-0.40.40.1-0.10.2-0.1-0.30.5-0.81.0-0.9-1.7
Patch foraging time to switch 0 sec0.30.40.90.9-0.60.60.7-0.70.60.7-0.80.7-0.3-0.50.30.4
Patch foraging water rate 0 sec0.71.22.5-1.61.3-1.3-1.11.1-1.0-1.01.3-1.21.1-0.60.60.6
Patch foraging water rate 12 sec1.52.34.6-2.11.9-1.9-1.61.6-1.8-1.61.7-1.61.4-0.20.30.5
Patch foraging water rate 18 sec3.64.87.0-2.72.3-2.3-2.22.2-2.2-2.42.3-2.32.4-1.61.61.7
Patch foraging water rate 24 sec1.42.03.5-1.91.2-1.2-1.41.4-1.5-1.31.6-1.61.6-1.21.21.1
Patch foraging water rate 6 sec0.71.12.2-1.51.2-1.2-1.01.0-0.8-1.01.2-1.21.1-0.40.40.7
Seeking ratio, delayed vs. immediate footshock0.50.51.01.0-0.80.80.8-0.80.80.6-1.00.9-0.5-0.1-0.1-0.0
Distance traveled before self-admin0.90.91.51.1-1.21.21.2-1.21.21.2-0.90.9-0.60.2-0.50.1
Distance traveled after self-admin0.20.20.9-0.20.4-0.4-0.40.4-0.30.10.4-0.50.8-0.50.01.0
Extensor digitorum longus weight0.31.31.8-1.21.3-1.3-1.21.2-1.2-1.31.3-1.31.1-0.50.70.4
Bone: elastic displacement0.10.10.60.2-0.80.80.2-0.20.20.2-0.20.3-0.40.0-0.1-0.3
Bone: elastic work0.20.30.7-0.80.4-0.4-0.60.6-0.4-0.80.7-0.60.10.3-0.2-0.5
Bone: endosteal estimation0.20.41.2-0.40.4-0.4-0.40.4-0.5-0.40.4-0.3-0.21.1-0.9-1.1
Bone: endosteal perimeter0.91.98.4-0.10.5-0.5-0.50.5-0.5-0.2-0.10.3-1.12.9-2.4-2.9
Epididymis fat weight0.71.73.7-0.91.9-1.9-1.71.7-1.6-1.21.0-1.00.70.20.5-1.0
Delta time in closed arm before/after self-admin0.20.20.6-0.60.4-0.4-0.30.3-0.4-0.80.6-0.50.50.0-0.20.6
Delta time in open arm before/after self-admin0.20.20.40.4-0.30.30.2-0.20.40.6-0.50.4-0.4-0.30.4-0.5
Diff in mean of infusions in LGA sessions1.41.52.4-1.31.5-1.5-1.51.5-1.4-1.51.2-1.31.1-0.30.60.1
Delay discount exponential model param1.51.62.7-1.01.3-1.3-1.31.3-1.2-0.90.8-1.11.5-1.51.71.2
Extinction: sum of active levers before priming0.20.20.7-0.1-0.20.20.2-0.2-0.3-0.3-0.10.3-0.40.7-0.8-0.9
Active lever presses in extinction session 61.91.93.1-1.61.5-1.5-1.51.5-1.8-1.51.5-1.51.3-0.60.70.3
Bone: final force0.20.41.20.40.0-0.00.6-0.60.70.4-0.40.4-0.51.1-1.1-0.3
Bone: final moment0.20.41.10.4-0.20.20.7-0.70.80.5-0.50.5-0.61.0-1.0-0.3
Food consumed during 24 hour testing period2.12.63.7-1.81.9-1.9-1.91.9-1.7-1.71.8-1.81.5-0.50.80.5
Glucose0.61.01.40.8-1.01.01.0-1.00.80.7-0.91.1-1.21.0-1.1-1.0
Heart weight0.40.51.90.7-0.40.40.5-0.50.40.7-0.40.30.3-1.21.11.4
Delay discount hyperbolic model param1.92.03.6-1.11.4-1.4-1.41.4-1.2-1.11.0-1.21.7-1.71.91.5
Intermittent access intake day 1-15 change0.80.71.0-1.00.8-0.8-0.90.9-0.9-1.01.0-0.90.8-0.80.80.4
Intermittent access intake escalation0.90.91.2-1.11.0-1.0-1.11.1-1.1-1.11.1-1.00.8-0.60.70.2
Intermittent access intake escalation 21.61.62.6-1.51.5-1.5-1.61.6-1.6-1.61.3-1.21.0-0.40.5-0.4
Intermitt. access day 1 inactive lever presses0.90.91.5-1.21.2-1.2-1.21.2-1.2-1.21.0-0.90.50.20.1-0.7
Intermitt. access day 15 inactive lever presses4.34.76.4-2.52.3-2.3-2.32.3-2.3-2.42.3-2.42.2-1.61.81.1
Intermitt. access escalation Index0.50.40.90.9-0.60.60.7-0.70.70.9-0.80.7-0.2-0.40.20.6
Intermittent access day 1 total infusions0.10.10.4-0.40.3-0.3-0.30.3-0.3-0.60.4-0.40.4-0.20.00.5
Intermittent access day 15 total infusions0.30.40.9-0.70.6-0.6-0.60.6-0.6-1.00.6-0.60.6-0.60.50.5
Intermittent access terminal intake (last 3 days)2.12.35.0-1.91.7-1.7-1.71.7-1.7-2.21.5-1.51.3-0.50.50.1
Intermittent access total infusions0.30.31.1-0.80.6-0.6-0.60.6-0.6-1.10.6-0.50.5-0.1-0.00.2
Intermittent access day 1 locomotion0.10.10.3-0.40.3-0.3-0.30.3-0.3-0.50.4-0.30.2-0.10.10.2
Intermittent access day 15 total locomotion0.40.40.8-0.90.6-0.6-0.70.7-0.7-0.80.8-0.80.50.00.00.1
Intermittent access total locomotion0.80.91.4-1.20.9-0.9-1.01.0-1.0-1.11.2-1.21.0-0.70.50.8
Intermittent access standard deviation1.41.42.0-1.31.0-1.0-1.01.0-1.0-1.41.2-1.21.4-1.41.31.3
Left kidney weight3.810.714.7-3.63.5-3.5-3.83.8-3.8-3.63.6-3.53.1-1.92.30.7
Right kidney weight6.618.626.8-4.94.8-4.8-5.15.1-5.2-5.04.8-4.63.9-1.82.60.5
Cocaine induced anxiety3.54.15.5-2.22.2-2.2-2.22.2-2.2-2.32.2-2.12.1-1.11.31.2
Post-drug Anxiety2.62.84.8-1.91.9-1.9-1.91.9-1.9-2.21.7-1.71.5-0.71.00.3
Baseline Anxiety1.21.21.81.2-1.21.21.1-1.11.11.1-1.31.3-1.30.6-0.5-1.1
Tail length0.31.01.61.2-1.31.31.0-1.01.11.3-1.21.1-0.8-0.30.2-0.2
Length with tail0.10.30.70.5-0.40.40.5-0.50.8-0.1-0.80.7-0.70.2-0.2-0.7
Length without tail0.30.62.5-0.91.1-1.1-0.70.7-0.5-1.60.5-0.50.40.10.1-0.2
Times rat made contact with spout2.22.55.5-1.61.1-1.1-1.01.0-1.0-1.41.5-1.51.9-2.42.02.3
Lifetime Intake0.40.51.4-0.90.7-0.7-0.60.6-0.6-1.20.7-0.70.7-0.30.20.5
Liver weight, left0.30.51.30.3-0.30.30.6-0.60.50.2-0.60.6-0.81.1-1.1-1.0
Liver weight, right1.82.95.61.4-1.11.11.5-1.51.61.3-1.71.7-2.12.4-2.2-2.0
Locomotor activity0.40.62.5-0.40.2-0.2-0.50.5-0.6-0.10.20.0-0.41.6-1.2-1.6
Locomotor testing distance0.40.71.60.8-1.01.00.9-0.90.71.2-0.70.8-0.70.8-0.9-0.3
Locomotor testing rearing1.62.58.70.6-0.80.80.7-0.70.70.5-1.01.2-1.93.0-2.6-2.7
Locomotion in novel chamber1.21.43.2-1.00.9-0.9-0.60.6-0.9-0.91.2-1.41.6-1.71.41.8
Locomotion in novel chamber post-restriction0.40.42.60.3-0.10.10.1-0.10.30.3-0.40.3-0.41.3-1.6-0.8
Fecal boli incidents, locomotor time 10.20.20.40.5-0.60.60.6-0.60.40.3-0.30.3-0.3-0.1-0.00.4
Change in fecal boli incidents, locomotor task0.20.21.2-0.60.4-0.4-0.40.4-0.6-1.10.3-0.30.3-0.20.2-0.2
Time >=10cm from walls, locomotor time 10.30.30.8-0.50.5-0.5-0.70.7-0.8-0.90.4-0.20.1-0.10.3-0.8
Bouts of movement, locomotor time 10.50.51.0-0.20.6-0.6-0.60.6-0.8-0.80.5-0.60.9-0.91.00.7
Total resting periods, locomotor time 10.20.20.50.10.2-0.2-0.20.2-0.4-0.70.2-0.20.6-0.70.70.6
Rest time, locomotor task time 10.30.31.8-0.20.2-0.2-0.10.1-0.1-0.50.4-0.50.7-0.70.41.3
Distance moved, locomotor task time 10.20.30.9-0.50.6-0.6-0.60.6-0.50.10.2-0.2-0.00.5-0.1-0.9
Vertical activity count, locomotor time 10.60.61.5-0.81.0-1.0-1.01.0-0.70.20.5-0.50.00.7-0.3-1.2
Time >=10cm from walls, locomotor time 21.41.52.8-1.41.4-1.4-1.61.6-1.4-1.71.2-1.10.60.40.1-0.7
Bouts of movement, locomotor time 20.30.30.60.6-0.70.70.8-0.80.70.6-0.70.6-0.4-0.30.20.1
Total resting periods, locomotor time 20.40.50.80.7-0.70.70.9-0.90.80.8-0.80.7-0.6-0.20.0-0.1
Rest time, locomotor task time 20.60.61.20.9-1.01.01.0-1.00.90.5-0.80.7-0.2-0.60.51.1
Distance moved, locomotor task time 21.31.52.4-1.41.5-1.5-1.61.6-1.3-0.61.2-1.10.60.9-0.6-1.0
Vertical activity count, locomotor time 21.61.73.0-1.61.7-1.7-1.71.7-1.3-0.51.4-1.30.60.7-0.4-0.9
Light reinforcement 10.20.40.8-0.60.6-0.6-0.70.7-0.9-0.50.5-0.40.10.6-0.5-0.9
Light reinforcement 21.52.03.1-1.71.7-1.7-1.61.6-1.8-1.71.4-1.10.51.0-0.9-1.4
Bone: marrow area0.10.31.2-0.30.2-0.2-0.30.3-0.4-0.30.3-0.1-0.31.1-0.9-1.1
Bone: maximum diameter0.61.11.9-0.91.4-1.4-1.01.0-0.9-0.81.0-0.90.31.4-1.1-1.0
Bone: maximum force0.10.10.7-0.00.1-0.10.3-0.30.5-0.1-0.10.1-0.40.8-0.8-0.3
Bone: maximum moment0.10.10.40.0-0.10.10.4-0.40.5-0.0-0.10.1-0.30.6-0.6-0.2
Mean time between licks in bursts1.52.03.41.9-1.81.81.7-1.71.71.8-1.41.3-0.90.0-0.30.6
Mean num. licks in bursts0.30.41.5-0.70.4-0.4-0.20.2-0.2-0.60.4-0.40.6-1.21.00.8
Cd content in liver0.20.30.60.4-0.40.40.8-0.80.70.5-0.60.5-0.40.2-0.40.1
Co content in liver0.40.40.7-0.60.5-0.5-0.80.8-0.8-0.60.6-0.50.10.8-0.5-0.8
Cu content in liver1.11.43.71.2-1.01.01.4-1.41.61.5-0.90.7-0.1-0.60.21.9
Fe content in liver0.20.21.30.10.0-0.00.3-0.30.30.3-0.20.3-0.51.0-1.1-0.4
K content in liver0.10.10.40.7-0.00.0-0.10.1-0.10.6-0.10.00.0-0.10.2-0.0
Mg content in liver0.60.61.01.0-0.90.90.4-0.40.40.9-0.60.6-0.80.8-0.7-0.9
Mn content in liver0.10.10.40.5-0.30.3-0.30.3-0.20.3-0.1-0.0-0.0-0.40.6-0.4
Na content in liver5.35.58.32.9-1.71.72.4-2.42.52.9-2.82.7-2.61.9-2.0-1.6
Rb content in liver0.50.61.10.8-0.90.90.7-0.70.70.7-0.70.7-0.91.0-1.0-0.6
Se content in liver1.11.42.0-0.90.9-0.9-1.31.3-1.3-0.81.3-1.31.4-1.21.31.0
Sr content in liver0.80.81.21.0-0.90.91.1-1.11.11.1-0.80.7-0.3-0.50.20.9
Zn content in liver0.00.00.40.00.1-0.10.0-0.00.10.10.1-0.20.2-0.20.20.6
Bone: minimum diameter0.20.41.9-0.20.7-0.7-0.30.3-0.2-0.20.2-0.1-0.31.4-1.2-1.0
Time in familiar zone, hab. session 10.70.71.3-0.80.3-0.3-0.70.7-0.5-0.70.9-0.91.0-1.21.11.1
Time in novel zone, hab. session 11.01.01.41.1-0.80.80.8-0.80.71.0-1.01.1-1.21.1-1.1-1.1
Total zone transitions, hab. session 12.23.14.31.6-2.12.12.1-2.12.11.5-1.81.9-1.91.0-1.2-1.0
Total locomotion distance, hab. session 10.40.51.80.0-0.80.80.5-0.50.5-0.2-0.30.5-1.01.0-1.0-1.4
Locomotion velocity, hab. session 10.60.82.20.2-0.80.80.7-0.70.70.0-0.50.7-1.21.3-1.3-1.5
Time in familiar zone, hab. session 22.02.02.8-1.31.5-1.5-1.51.5-1.4-1.11.4-1.51.7-1.31.41.4
Time in novel zone, hab. session 21.81.82.91.5-1.71.71.4-1.41.31.3-1.41.4-1.40.7-0.8-0.9
Total zone transitions, hab. session 20.10.10.4-0.60.3-0.3-0.20.20.0-0.40.6-0.50.3-0.10.00.4
Total locomotion distance, hab. session 20.71.02.2-1.50.8-0.8-1.11.1-0.9-1.51.3-1.20.60.2-0.1-0.3
Locomotion velocity, hab. session 20.60.92.1-1.40.7-0.7-1.01.0-0.8-1.51.2-1.10.50.3-0.2-0.4
Novel to familiar place preference ratio0.40.41.40.6-0.20.20.1-0.10.10.7-0.1-0.00.4-1.21.11.1
Novelty place preference0.40.41.70.3-0.10.1-0.20.2-0.20.40.1-0.30.7-1.31.21.2
Time in novel zone, NPP test0.50.62.30.3-0.20.2-0.10.1-0.20.40.2-0.30.7-1.51.41.4
Total zone transitions, NPP test0.50.71.40.7-1.21.21.0-1.01.20.6-0.80.8-0.80.0-0.2-0.2
Total locomotion distance, NPP test0.20.21.0-0.2-0.40.40.0-0.00.1-0.30.10.1-0.50.8-0.7-1.0
Locomotion velocity, NPP test0.10.20.9-0.3-0.20.2-0.10.10.0-0.50.2-0.0-0.40.7-0.6-1.0
Intraocular pressure0.60.94.60.30.2-0.20.2-0.20.40.7-0.20.3-0.72.1-2.1-0.9
Delta distance traveled before/after self-admin3.23.54.9-1.82.2-2.2-2.22.2-2.0-1.61.9-2.02.0-1.21.31.3
Delta ambulatory time before/after self-admin1.82.02.8-1.41.7-1.7-1.61.6-1.4-1.11.4-1.51.5-1.01.01.0
Parametrial fat weight0.20.30.5-0.70.5-0.5-0.30.3-0.2-0.30.7-0.70.5-0.60.60.7
Pavlov. Cond. lever latency0.70.91.50.9-1.21.21.2-1.21.20.9-1.00.9-0.6-0.70.40.5
Pavlov. Cond. magazine entry latency0.30.41.10.9-0.20.20.5-0.50.61.1-0.70.6-0.40.6-0.60.1
Pavlov. Cond. change in total contacts0.40.42.20.60.3-0.3-0.00.00.10.7-0.20.3-0.51.5-1.2-0.7
Pavlov. Cond. index score0.10.10.40.30.5-0.5-0.20.2-0.10.3-0.00.0-0.00.6-0.5-0.2
Pavlov. Cond. latency score0.10.20.50.00.7-0.7-0.40.4-0.40.10.1-0.20.10.6-0.4-0.2
Pavlov. Cond. lever contacts1.11.32.4-0.91.5-1.5-1.51.5-1.4-0.91.2-1.10.80.6-0.2-0.4
Pavlov. Cond. magazine entry number0.30.30.9-0.90.1-0.1-0.50.5-0.5-0.90.7-0.60.5-0.70.70.2
Pavlov. Cond. intertrial magazine entries0.80.91.4-1.11.1-1.1-1.21.2-1.0-1.11.1-1.00.50.7-0.4-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.30.4-0.4-0.10.10.00.4-0.10.1-0.10.7-0.6-0.2
Pavlov. Cond. response bias0.10.20.4-0.00.6-0.6-0.50.5-0.40.00.3-0.30.20.6-0.4-0.2
Pavlov. Cond. lever latency1.11.42.91.2-1.71.71.3-1.31.31.2-1.21.1-1.20.5-0.7-0.4
Pavlov. Cond. magazine entry latency0.40.41.1-0.51.1-1.1-0.60.6-0.7-0.60.5-0.50.6-0.20.40.2
Pavlov. Cond. change in total contacts0.20.20.9-0.10.6-0.60.0-0.0-0.2-0.2-0.10.2-0.30.9-0.7-0.8
Pavlov. Cond. index score0.70.81.8-1.01.3-1.3-1.01.0-1.1-1.10.9-0.80.8-0.10.4-0.0
Pavlov. Cond. latency score1.01.22.5-1.21.6-1.6-1.21.2-1.3-1.21.1-1.01.0-0.40.60.1
Pavlov. Cond. lever contacts1.01.42.3-1.31.5-1.5-1.31.3-1.4-1.21.2-1.21.1-0.40.60.2
Pavlov. Cond. magazine entry number0.40.51.20.7-1.11.10.7-0.70.90.8-0.70.6-0.6-0.2-0.20.1
Pavlov. Cond. intertrial magazine entries0.10.20.8-0.4-0.40.4-0.20.2-0.1-0.30.2-0.30.3-0.90.70.6
Pavlov. Cond. lever-magazine prob. diff.0.60.71.5-1.01.2-1.2-0.90.9-1.0-1.00.9-0.80.7-0.10.4-0.0
Pavlov. Cond. response bias0.40.51.1-0.71.0-1.0-0.80.8-0.8-0.70.7-0.60.6-0.00.20.0
Time in closed arm before self-admin2.32.65.11.6-1.01.00.9-0.91.61.9-1.71.6-1.91.9-1.8-2.3
Time in closed arm after self-admin0.80.83.00.30.1-0.10.1-0.10.50.2-0.50.5-0.91.7-1.7-1.6
Time in open arm before self-admin0.60.62.2-0.50.2-0.2-0.10.1-0.7-0.80.7-0.61.0-1.31.11.5
Time in open arm after self-admin0.30.31.6-0.30.1-0.1-0.10.1-0.5-0.20.2-0.20.5-1.31.10.6
Bone: periosteal estimation0.30.72.8-0.50.7-0.7-0.40.4-0.3-0.50.3-0.2-0.41.7-1.4-1.4
Bone: periosteal perimeter0.81.24.9-0.40.8-0.8-0.60.6-0.5-0.40.10.0-0.72.2-1.9-2.1
Bone: post-yield work0.40.61.30.7-0.70.71.1-1.11.10.6-0.80.8-0.50.2-0.40.6
Progressive ratio test 1 active lever presses1.31.33.6-0.70.7-0.7-0.60.6-0.6-1.20.8-0.91.3-1.91.81.6
Progressive ratio test 1 breakpoint1.41.43.6-0.80.8-0.8-0.70.7-0.7-1.30.9-1.01.3-1.91.91.6
Progressive ratio test 1 inactive lever presses0.50.61.3-0.60.6-0.6-0.60.6-0.6-0.90.5-0.60.8-1.11.10.7
Progressive ratio test 2 active lever presses0.40.41.0-0.70.7-0.7-0.70.7-0.7-1.00.7-0.70.6-0.20.20.1
Progressive ratio test 2 breakpoint0.30.30.7-0.60.6-0.6-0.70.7-0.7-0.80.6-0.60.5-0.20.20.0
Progressive ratio test 2 inactive lever presses0.40.51.3-0.90.6-0.6-0.80.8-0.8-1.10.8-0.70.50.00.1-0.0
Incentive Sensitization - Responses0.30.30.6-0.50.5-0.5-0.60.6-0.6-0.50.4-0.30.10.5-0.4-0.7
Incentive Sensitization - Breakpoint0.20.20.4-0.40.5-0.5-0.60.6-0.6-0.40.4-0.30.10.5-0.4-0.7
Sum of active levers in priming session hrs 5-60.20.20.4-0.30.5-0.5-0.60.6-0.6-0.60.5-0.50.40.2-0.1-0.0
Progressive ratio0.60.71.0-0.70.7-0.7-0.80.8-0.9-0.90.9-0.81.0-0.70.60.7
Food seeking constrained by brief footshock2.53.15.6-2.41.8-1.8-2.12.1-1.9-2.22.2-2.01.30.4-0.1-0.3
Seeking ratio, punishment vs. effort0.20.20.9-0.2-0.00.0-0.00.00.20.1-0.10.1-0.51.0-0.8-0.9
Retroperitoneal fat weight0.92.94.6-2.11.8-1.8-2.12.1-2.0-1.72.2-2.01.20.30.1-0.7
Reaction time number correct0.50.71.10.7-0.90.91.0-1.01.00.9-0.60.6-0.60.7-1.00.1
Reaction time mean minus median0.00.10.1-0.10.2-0.2-0.30.3-0.3-0.30.2-0.20.10.2-0.2-0.3
Reaction time mean minus median AUC0.10.10.3-0.30.2-0.2-0.40.4-0.5-0.60.4-0.50.4-0.30.3-0.0
Reaction time num false alarms0.10.20.50.7-0.20.20.3-0.30.50.4-0.60.4-0.30.4-0.6-0.1
Reaction time num false alarms AUC0.00.00.20.4-0.00.00.1-0.10.30.2-0.20.10.2-0.0-0.20.5
Reaction time trials correct on left0.50.71.10.7-0.90.91.0-1.01.00.9-0.60.6-0.60.7-1.00.1
Reaction time trials on left0.50.71.10.7-0.90.91.0-1.01.00.9-0.60.6-0.60.7-1.00.1
Reaction time mean0.30.41.70.4-0.10.10.3-0.30.20.3-0.20.10.4-1.31.11.3
Reaction time mean AUC0.30.41.30.5-0.30.30.4-0.40.40.4-0.40.20.3-1.11.01.1
Median of all reaction times0.70.93.90.4-0.20.20.4-0.40.30.5-0.20.00.7-2.01.82.0
Reaction time omissions0.50.71.51.2-1.01.00.9-0.91.01.0-1.00.8-0.4-0.40.20.5
Reaction time false alarm rate0.00.00.10.20.3-0.3-0.20.2-0.1-0.0-0.20.00.2-0.20.10.1
Reaction time premature initiation rate1.52.03.3-1.41.7-1.7-1.81.8-1.8-1.11.3-1.10.30.9-0.5-1.8
Reaction time premature initiations0.60.82.0-0.90.9-0.9-0.90.9-0.9-0.40.8-0.70.01.0-0.9-1.4
Std. dev. reaction times0.10.10.3-0.20.3-0.3-0.30.3-0.2-0.40.3-0.30.4-0.50.50.5
Reaction time trials completed0.50.71.10.7-0.90.91.0-1.01.00.9-0.60.6-0.60.7-1.00.1
Reaction time trials AUC0.30.40.90.5-0.70.70.8-0.80.90.7-0.40.4-0.40.7-0.90.2
Run reversals in cocaine runway, females0.00.00.3-0.0-0.10.1-0.10.1-0.2-0.20.2-0.20.3-0.10.10.6
Run reversals in cocaine runway, males1.31.32.70.9-1.11.11.1-1.10.91.0-0.91.0-1.21.6-1.6-0.8
Latency to leave start box in cocaine runway1.51.72.9-1.71.4-1.4-1.41.4-1.1-1.51.6-1.61.2-0.40.50.5
Latency to leave start box in cocaine runway, F2.93.24.8-1.71.7-1.7-1.61.6-1.3-1.41.8-2.02.0-2.12.22.0
Latency to leave start box in cocaine runway, M0.70.73.4-0.3-0.10.10.1-0.10.0-0.20.10.1-0.71.9-1.7-1.3
Std. dev. time between licks in bursts0.91.02.4-1.30.8-0.8-1.01.0-1.0-1.51.1-0.80.21.1-0.8-1.2
Total sessions with >9 infusions0.50.61.5-1.00.8-0.8-0.70.7-0.7-1.20.9-0.90.7-0.10.10.3
Short access day 1 total inactive lever presses4.85.37.7-2.62.4-2.4-2.42.4-2.4-2.82.7-2.62.5-1.31.51.6
Short access day 10 total inactive lever presses5.96.69.8-3.13.1-3.1-3.13.1-3.1-2.92.7-2.62.0-0.20.7-0.6
Short access day 1 total infusions1.21.22.2-1.21.1-1.1-0.90.9-0.9-1.51.3-1.31.2-0.90.91.1
Short access day 10 total infusions1.31.42.6-1.41.2-1.2-1.21.2-1.2-1.61.3-1.21.2-0.70.60.9
Short access total infusions0.80.92.0-1.10.9-0.9-0.80.8-0.8-1.41.0-1.01.0-0.60.60.9
Short access day 1 locomotion1.11.21.5-1.21.0-1.0-1.01.0-1.0-1.21.2-1.21.2-1.21.21.1
Short access day 10 total locomotion3.64.15.7-2.42.2-2.2-2.22.2-2.2-2.12.4-2.32.0-1.11.21.1
Short access total locomotion1.41.52.1-1.41.2-1.2-1.21.2-1.2-1.41.4-1.41.2-0.80.90.9
One hour access (0.3 mA shock)0.20.20.9-0.50.4-0.4-0.50.5-0.5-0.80.1-0.0-0.10.3-0.3-0.9
Compulsive drug intake0.80.81.31.0-0.80.80.9-0.90.91.1-1.21.1-0.90.5-0.4-0.6
One hour access (shock baseline)0.60.71.9-1.10.9-0.9-1.01.0-1.0-1.40.7-0.60.30.4-0.4-0.6
Social response proportion0.40.51.00.7-0.40.40.7-0.70.81.0-0.70.6-0.60.7-0.9-0.3
Social responses0.30.40.80.6-0.30.30.5-0.50.70.8-0.60.6-0.70.8-0.9-0.6
Social time0.70.92.1-0.90.7-0.7-0.60.6-0.8-0.60.9-0.91.2-1.41.21.4
Soleus weight0.92.53.8-1.81.7-1.7-1.71.7-1.6-1.82.0-2.01.5-0.81.00.6
Bone: stiffness0.20.30.80.4-0.30.30.8-0.80.90.4-0.60.5-0.40.3-0.40.0
Tibialis anterior weight0.00.10.1-0.10.4-0.4-0.20.2-0.2-0.10.2-0.30.3-0.30.40.2
Time to tail flick, vehicle, before self-admin0.80.81.4-1.01.0-1.0-1.11.1-1.2-0.81.0-0.90.60.00.5-0.4
Time to tail flick, vehicle, after self-admin0.50.61.2-0.71.1-1.1-1.11.1-0.6-0.70.5-0.60.4-0.30.4-0.5
Time to tail flick, test, before self-admin0.60.61.4-0.51.2-1.2-1.01.0-0.5-0.30.5-0.70.8-0.80.70.5
Time to tail flick, test, after self-admin1.61.72.7-1.41.6-1.6-1.61.6-1.3-0.81.4-1.51.2-0.70.80.2
Delta time to tail flick, vehicle, before/after SA0.60.61.30.9-0.80.80.9-0.91.10.8-1.00.9-0.70.2-0.5-0.2
Delta time to tail flick, test, before/after SA0.10.10.5-0.50.1-0.1-0.20.2-0.5-0.10.7-0.50.20.2-0.1-0.1
Tibia length1.23.55.91.7-1.91.92.4-2.42.41.7-2.32.3-1.90.6-0.9-0.3
Ambulatory time before self-admin0.20.20.70.3-0.50.50.4-0.40.60.5-0.20.10.2-0.70.30.8
Ambulatory time after self-admin0.50.51.6-0.50.7-0.7-0.70.7-0.5-0.20.6-0.81.1-0.80.31.3
Bone: tissue strength0.40.41.60.2-1.31.30.7-0.70.70.1-0.40.4-0.4-0.60.30.1
Total heroin consumption0.20.20.5-0.60.5-0.5-0.50.5-0.7-0.60.6-0.50.30.3-0.2-0.2
Bone: trabecular number0.40.71.51.2-1.11.10.6-0.60.71.0-0.90.8-0.80.0-0.0-0.6
Bone: trabecular spacing1.52.03.6-1.91.6-1.6-1.41.4-1.5-1.81.7-1.61.3-0.40.50.5
Bone: trabecular thickness0.40.51.90.5-0.20.20.3-0.30.40.4-0.40.4-0.81.4-1.2-1.1
Bone: trabecular tissue density1.62.24.11.5-1.51.52.0-2.01.91.4-1.61.6-1.50.7-0.9-0.2
Water consumed over 24 hours0.40.51.1-1.00.6-0.6-0.70.7-0.7-1.10.7-0.70.5-0.70.80.0
Number of responses in last shaping day0.10.10.3-0.30.1-0.1-0.10.1-0.1-0.50.5-0.50.3-0.20.20.5