Hub : Genes

Tsnaxip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Tsnaxip1 0.11 0.06 7.3e-07 0.14 0.12 0.13 0.13 1.3e-07 4.2e-07 3.1e-07 1.9e-07
2 Brain gene expression Tsnaxip1 0.13 0.07 3.2e-15 0.17 0.16 0.16 0.18 1.2e-15 6.1e-15 3.3e-15 1.7e-16
3 Brain mRNA stability Tsnaxip1 0.14 0.07 2.9e-15 0.13 0.16 0.15 0.16 3.1e-12 7.0e-15 3.0e-14 2.8e-14
4 IC gene expression Tsnaxip1 0.13 0.08 9.2e-06 0.1 0.1 0.04 0.1 7.2e-05 5.4e-05 8.1e-03 7.8e-05
5 pVTA gene expression Tsnaxip1 0.03 0.02 4.0e-03 0.02 0.03 0.02 0.02 1.2e-02 3.2e-03 1.8e-02 1.8e-02
6 NAcc gene expression Tsnaxip1 0.12 0.06 0.0e+00 0.14 0.14 0.14 0.14 6.9e-20 3.8e-20 3.7e-20 5.1e-20
7 PL gene expression Tsnaxip1 0.11 0.06 2.2e-16 0.15 0.13 0.14 0.14 1.5e-16 3.1e-14 9.8e-15 4.6e-15
8 Eye alternative polyA NM_001109130.1 0.42 0.18 1.5e-03 0.06 0.08 0.07 0.05 5.1e-02 2.7e-02 3.3e-02 6.6e-02
9 IL gene expression Tsnaxip1 0.28 0.16 1.3e-04 0.12 0.11 0.11 0.13 8.3e-04 1.4e-03 1.2e-03 6.0e-04
10 IC intron excision ratio chr19_50627041_50627885 0.1 0.07 8.0e-04 0.04 0.04 0.03 0.03 1.2e-02 1.0e-02 1.9e-02 1.4e-02
11 Brain alternative TSS XM_017601344.3 0.04 0.03 1.1e-03 0.02 0.01 0.02 0.01 6.0e-03 1.7e-02 2.5e-03 2.2e-02
12 Brain alternative TSS XM_017601344.3 0.04 0.03 2.3e-03 0.01 0.01 0.02 0 1.5e-02 2.8e-02 6.1e-03 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.10.2-0.2-0.40.4-0.4-0.4-0.4-0.30.4-0.20.40.00.0
Area under the delay curve0.00.00.20.0-0.0-0.10.10.1-0.00.10.0-0.4-0.00.40.5
BMI with tail0.10.41.5-0.4-0.40.4-0.6-0.3-0.3-0.30.5-0.7-0.21.21.2
BMI without tail0.00.10.50.20.1-0.1-0.00.20.10.3-0.0-0.4-0.50.60.7
Body weight0.31.32.0-0.9-1.21.2-1.4-1.1-0.9-1.11.2-0.70.61.41.4
Weight adjusted by age0.00.00.1-0.1-0.00.00.1-0.1-0.10.0-0.00.10.3-0.1-0.1
Bone surface1.11.92.9-1.1-1.41.7-1.7-1.7-1.5-1.61.6-0.91.40.80.7
Bone volume0.81.52.5-0.9-1.21.5-1.4-1.6-1.4-1.41.4-0.71.60.30.1
Breakpoint value in progressive ratio session1.61.92.31.31.3-1.41.51.41.51.1-1.51.5-1.1-1.3-1.3
Number of licking bursts0.71.12.2-1.0-1.01.1-1.4-0.9-0.9-1.01.1-0.70.11.41.5
Context. condit. distance diff. score0.20.20.70.30.5-0.10.10.10.4-0.0-0.20.8-0.1-0.8-0.7
Locomotion velocity, session 10.10.10.5-0.2-0.20.2-0.3-0.1-0.1-0.20.3-0.7-0.20.50.6
Locomotion distance, session 10.10.20.50.50.5-0.40.30.50.50.4-0.40.4-0.7-0.2-0.1
Locomotion velocity, session 20.91.12.31.11.2-0.90.71.11.20.8-1.01.3-1.5-0.8-0.5
Locomotion distance, session 20.20.31.30.60.6-0.40.10.60.70.4-0.40.6-1.1-0.10.1
Locomotion velocity, session 30.20.20.60.40.4-0.50.40.60.40.5-0.50.1-0.80.10.3
Locomotion distance, session 30.10.10.30.20.3-0.20.30.20.10.3-0.30.6-0.0-0.4-0.4
Stereotopy head waving bouts, day 30.10.20.4-0.4-0.40.2-0.3-0.2-0.5-0.40.3-0.60.20.60.6
Stereotopy head waving duration, day 30.60.70.9-0.8-0.90.8-0.9-0.7-0.8-1.00.8-0.80.40.91.0
Locomotion velocity, session 70.20.31.20.20.3-0.00.3-0.10.1-0.1-0.10.40.6-1.0-1.1
Locomotion distance, session 70.10.20.80.20.3-0.10.40.10.10.1-0.30.50.3-0.8-0.9
Stereotopy head waving bouts, day 70.30.40.6-0.6-0.60.5-0.6-0.5-0.6-0.60.5-0.60.30.70.8
Stereotopy head waving duration, day 70.91.11.9-1.0-1.10.9-1.0-0.8-1.0-0.91.0-1.20.51.31.4
Locomotion velocity, session 80.10.10.40.10.10.0-0.30.10.20.10.00.0-0.60.30.4
Locomotion distance, session 80.50.71.30.91.0-0.70.50.71.10.6-0.71.1-1.1-0.7-0.5
Degree of sensitization distance0.10.10.3-0.1-0.10.10.1-0.2-0.2-0.20.1-0.10.5-0.3-0.4
Degree of sensitization stereotypy0.50.50.6-0.7-0.80.6-0.7-0.6-0.7-0.70.7-0.80.50.80.8
Conditioned locomotion1.61.82.9-1.5-1.31.7-1.7-1.6-1.3-1.61.5-0.71.20.90.8
Cocaine response after cond. corrected0.60.82.6-0.8-1.00.6-0.4-0.7-0.8-0.60.8-1.61.10.80.5
Cocaine response after cond. not corrected0.20.31.7-0.3-0.60.00.1-0.1-0.2-0.10.3-1.30.40.80.5
Cocaine response before conditioning1.01.22.81.21.0-1.31.01.31.31.2-1.20.9-1.7-0.30.0
Saline control response4.05.47.6-2.2-2.32.4-2.8-2.3-1.9-2.72.5-2.11.32.52.5
Bone: connectivity density0.00.00.10.10.1-0.1-0.00.10.10.2-0.10.3-0.4-0.1-0.0
Bone: cortical apparent density0.40.61.4-0.10.8-1.01.00.90.51.2-0.90.5-0.7-0.5-0.4
Bone: cortical area0.30.51.9-0.4-0.40.7-0.4-0.8-0.8-0.90.6-0.21.4-0.4-0.7
Bone: cortical porosity0.70.82.21.50.9-0.50.50.50.90.3-0.61.1-0.4-1.2-1.2
Bone: cortical porosity0.60.71.61.30.9-0.50.50.40.80.3-0.50.9-0.2-1.2-1.2
Bone: cortical thickness0.10.20.9-0.4-0.30.5-0.2-0.5-0.6-0.50.4-0.20.9-0.2-0.4
Bone: cortical thickness0.60.72.81.00.40.10.3-0.2-0.1-0.2-0.21.20.9-1.5-1.7
Bone: cortical tissue density0.50.61.5-0.10.8-1.01.11.00.51.2-0.90.5-0.7-0.4-0.3
Condit. Reinf. active minus inactive responses4.14.66.22.22.3-2.22.52.12.02.1-2.21.9-1.2-2.4-2.3
Condit. Reinf. active-inactive response ratio3.43.64.92.02.0-2.02.21.91.92.0-2.01.6-1.1-1.9-1.9
Condit. Reinf. active responses3.13.95.22.02.2-2.02.21.91.81.9-2.01.8-1.1-2.3-2.2
Condit. Reinf. inactive responses0.30.30.70.50.6-0.50.60.40.20.4-0.60.6-0.1-0.8-0.8
Incentive salience index mean2.32.94.11.71.9-1.71.81.61.61.6-1.71.6-0.9-2.0-2.0
Condit. Reinf. lever presses0.20.30.70.60.7-0.40.40.40.70.3-0.40.5-0.2-0.8-0.8
Condit. Reinf. active minus inactive responses0.70.91.3-1.0-0.81.0-0.9-1.0-1.1-1.01.0-0.81.20.60.5
Condit. Reinf. active-inactive response ratio0.60.71.3-1.0-0.90.9-0.7-0.9-1.2-0.80.8-0.81.10.60.5
Condit. Reinf. active responses0.30.40.8-0.6-0.40.8-0.7-0.8-0.6-0.90.7-0.40.70.30.2
Condit. Reinf. inactive responses0.30.40.60.70.8-0.50.40.50.80.2-0.50.8-0.5-0.7-0.7
Condit. Reinf. lever presses2.53.56.61.92.2-1.71.51.82.01.7-1.92.6-2.1-1.6-1.2
Condit. Reinf. lever reinforcers received0.00.00.2-0.10.10.3-0.3-0.3-0.1-0.40.20.20.2-0.1-0.2
Conditioned reinforcement - actives0.81.32.31.51.2-1.31.31.21.21.4-1.10.6-1.0-0.8-0.9
Conditioned reinforcement - inactives0.20.30.4-0.5-0.50.5-0.4-0.5-0.6-0.50.5-0.60.60.40.2
Conditioned locomotion0.71.01.2-0.9-1.01.1-1.1-1.1-1.0-1.11.1-1.01.00.80.6
Patch foraging indifference point 0 sec2.54.65.8-2.2-2.32.4-2.4-2.3-2.1-2.12.3-1.91.92.01.8
Patch foraging indifference point AUC1.42.03.7-1.3-1.31.7-1.9-1.6-1.4-1.71.6-0.80.91.21.2
Delay disc. indifference point, 0s delay0.60.61.40.90.6-0.90.71.00.91.0-0.80.1-1.20.20.3
Delay disc. indifference point, 16s delay0.00.00.10.1-0.10.1-0.1-0.2-0.3-0.20.2-0.30.30.00.0
Delay disc. indifference point, 2s delay0.30.40.6-0.5-0.60.6-0.7-0.6-0.6-0.60.6-0.60.40.70.8
Delay disc. indifference point, 24s delay0.00.00.0-0.10.10.0-0.1-0.0-0.20.10.00.2-0.0-0.2-0.0
Delay disc. indifference point, 4s delay0.10.10.4-0.10.2-0.40.50.40.30.6-0.4-0.0-0.30.30.4
Delay disc. indifference point, 8s delay0.00.00.2-0.1-0.1-0.10.20.1-0.10.0-0.0-0.50.30.30.3
Indifference point function ln k0.20.31.00.50.4-0.71.00.60.50.8-0.6-0.00.2-0.5-0.6
Indifference point function log k0.20.31.00.50.4-0.71.00.60.50.8-0.6-0.00.2-0.5-0.6
Patch foraging total patch changes 0 sec2.44.55.6-2.2-2.22.3-2.4-2.3-2.1-2.12.3-1.81.91.91.8
Patch foraging total patch changes 12 sec2.43.15.2-1.8-1.82.0-2.3-1.9-1.8-1.81.9-1.21.11.61.7
Patch foraging total patch changes 18 sec1.82.84.3-1.4-1.72.1-1.9-2.1-1.9-2.01.9-0.82.00.70.4
Patch foraging total patch changes 24 sec0.30.51.1-0.6-0.60.8-1.1-0.7-0.6-0.50.70.1-0.10.81.1
Patch foraging total patch changes 6 sec2.13.14.8-1.9-1.81.9-2.2-1.8-1.5-1.61.8-1.40.82.02.1
Patch foraging time to switch 0 sec0.71.42.51.01.2-1.31.11.31.31.6-1.21.0-1.5-0.7-0.5
Patch foraging water rate 0 sec1.12.43.4-1.3-1.71.6-1.6-1.6-1.7-1.91.6-1.41.51.21.0
Patch foraging water rate 12 sec0.10.30.7-0.5-0.80.5-0.4-0.5-0.6-0.50.5-0.40.60.40.3
Patch foraging water rate 18 sec0.10.10.4-0.5-0.50.4-0.2-0.5-0.5-0.10.30.20.60.00.0
Patch foraging water rate 24 sec0.10.10.60.2-0.20.00.3-0.1-0.2-0.4-0.0-0.00.7-0.4-0.5
Patch foraging water rate 6 sec0.81.23.5-1.0-1.11.1-0.7-1.3-1.4-1.31.0-0.51.9-0.0-0.3
Seeking ratio, delayed vs. immediate footshock2.42.93.8-1.8-1.71.8-1.7-1.8-1.8-1.91.9-1.81.71.21.1
Distance traveled before self-admin1.11.43.8-1.5-0.71.4-1.0-1.5-1.5-1.21.10.41.9-0.3-0.3
Distance traveled after self-admin0.10.20.4-0.7-0.30.4-0.4-0.4-0.6-0.40.4-0.10.50.10.2
Extensor digitorum longus weight1.04.06.92.22.0-1.61.81.61.81.8-1.92.6-1.1-2.5-2.5
Bone: elastic displacement1.82.03.0-1.5-1.71.3-1.1-1.4-1.7-1.41.4-1.71.71.10.8
Bone: elastic work0.70.92.3-1.1-1.00.9-0.5-1.0-1.2-0.90.8-0.91.50.40.1
Bone: endosteal estimation0.10.10.6-0.5-0.10.3-0.1-0.4-0.3-0.30.2-0.00.8-0.4-0.5
Bone: endosteal perimeter0.10.31.1-0.1-0.10.6-0.3-0.6-0.4-0.70.40.11.0-0.6-0.7
Epididymis fat weight1.75.88.9-2.3-2.62.8-2.5-2.8-2.7-2.82.6-1.63.01.31.0
Delta time in closed arm before/after self-admin0.10.10.4-0.2-0.30.2-0.3-0.2-0.2-0.50.3-0.6-0.00.40.5
Delta time in open arm before/after self-admin0.00.00.2-0.5-0.30.10.1-0.1-0.2-0.10.0-0.00.40.1-0.0
Diff in mean of infusions in LGA sessions0.40.51.10.80.7-0.60.50.70.80.4-0.71.0-0.9-0.5-0.3
Delay discount exponential model param0.00.00.2-0.1-0.00.2-0.1-0.2-0.1-0.20.10.20.2-0.4-0.5
Extinction: sum of active levers before priming0.60.71.10.80.8-1.01.01.01.00.6-1.00.5-0.9-0.5-0.6
Active lever presses in extinction session 60.00.00.1-0.00.1-0.10.10.00.1-0.1-0.0-0.10.2-0.2-0.3
Bone: final force1.21.93.61.31.5-1.21.41.11.21.0-1.31.8-0.5-1.9-1.9
Bone: final moment0.50.91.90.71.0-0.81.00.70.80.6-0.91.1-0.2-1.4-1.4
Food consumed during 24 hour testing period0.10.10.4-0.3-0.20.5-0.5-0.5-0.3-0.70.30.40.3-0.2-0.2
Glucose1.11.73.20.81.2-1.61.61.61.31.8-1.50.7-1.4-0.5-0.3
Heart weight0.00.10.2-0.0-0.1-0.10.00.1-0.10.4-0.0-0.5-0.20.40.4
Delay discount hyperbolic model param0.10.10.3-0.1-0.10.2-0.2-0.3-0.2-0.30.20.20.3-0.4-0.5
Intermittent access intake day 1-15 change1.22.44.01.41.7-1.71.71.71.62.0-1.71.3-1.6-0.9-0.7
Intermittent access intake escalation1.22.54.31.41.7-1.81.71.81.62.1-1.71.3-1.7-0.9-0.7
Intermittent access intake escalation 21.01.22.51.01.1-1.31.21.21.11.6-1.20.8-1.1-0.6-0.5
Intermitt. access day 1 inactive lever presses0.10.31.00.10.1-0.3-0.10.40.40.2-0.1-0.5-1.00.81.0
Intermitt. access day 15 inactive lever presses0.00.10.20.20.3-0.20.20.10.10.3-0.20.40.0-0.5-0.4
Intermitt. access escalation Index0.30.40.9-0.9-0.80.5-0.6-0.5-0.7-0.70.6-0.80.30.60.6
Intermittent access day 1 total infusions0.20.30.80.60.1-0.40.20.50.60.3-0.1-0.9-0.70.60.5
Intermittent access day 15 total infusions1.62.44.01.71.5-1.91.71.91.82.0-1.60.4-1.8-0.4-0.4
Intermittent access terminal intake (last 3 days)2.83.65.62.11.9-2.22.12.22.22.4-2.00.9-2.0-0.9-0.9
Intermittent access total infusions2.32.84.12.01.6-1.91.91.92.01.9-1.70.7-1.7-0.9-0.9
Intermittent access day 1 locomotion1.41.84.4-1.2-1.41.1-1.2-1.0-1.0-1.31.3-2.10.71.71.5
Intermittent access day 15 total locomotion0.40.72.5-0.7-0.80.5-0.6-0.5-0.6-0.20.7-1.60.41.31.1
Intermittent access total locomotion0.20.21.7-0.2-0.40.1-0.1-0.1-0.2-0.10.4-1.30.20.70.5
Intermittent access standard deviation0.10.30.6-0.3-0.60.5-0.5-0.5-0.5-0.30.6-0.80.50.50.4
Left kidney weight1.57.114.72.82.8-2.42.22.52.62.6-2.73.8-2.7-2.4-2.0
Right kidney weight1.77.616.73.02.9-2.42.32.42.62.7-2.84.1-2.5-2.6-2.2
Cocaine induced anxiety2.94.25.4-2.2-2.12.0-2.1-1.9-2.1-2.02.1-2.31.42.22.0
Post-drug Anxiety1.01.12.4-1.1-1.10.8-1.0-0.7-0.9-0.80.9-1.20.31.51.6
Baseline Anxiety1.51.82.41.41.3-1.51.41.51.41.6-1.41.2-1.4-0.7-0.6
Tail length0.00.10.50.70.2-0.10.00.10.30.1-0.10.3-0.2-0.3-0.3
Length with tail0.10.40.7-0.2-0.70.8-0.8-0.8-0.3-0.80.60.30.50.30.3
Length without tail0.51.52.1-1.3-1.41.4-1.4-1.3-1.0-1.51.2-0.61.01.21.1
Times rat made contact with spout1.11.31.8-1.2-1.11.2-1.3-1.2-1.2-1.31.2-0.91.00.90.9
Lifetime Intake1.92.33.51.91.5-1.81.81.81.81.7-1.60.6-1.4-0.9-1.0
Liver weight, left0.30.51.0-0.8-0.70.7-0.9-0.6-0.6-0.60.7-0.30.00.81.0
Liver weight, right0.30.61.2-0.4-0.90.9-1.1-0.8-0.5-1.10.8-0.20.20.90.9
Locomotor activity2.33.65.5-1.9-1.92.2-2.0-2.3-2.0-2.22.1-1.42.31.00.7
Locomotor testing distance1.73.14.3-1.6-1.82.0-1.8-2.0-1.8-2.02.0-1.52.11.20.9
Locomotor testing rearing0.20.51.7-0.4-0.60.8-0.5-0.9-0.8-0.70.6-0.11.3-0.1-0.4
Locomotion in novel chamber2.22.83.6-1.7-1.71.7-1.7-1.8-1.8-1.71.8-1.91.71.21.0
Locomotion in novel chamber post-restriction1.42.33.1-1.5-1.61.5-1.4-1.5-1.8-1.61.6-1.61.61.21.1
Fecal boli incidents, locomotor time 10.60.91.5-1.2-1.00.9-1.1-0.9-1.0-0.70.9-0.80.41.01.1
Change in fecal boli incidents, locomotor task0.40.41.40.60.5-0.70.50.80.90.6-0.60.4-1.20.30.4
Time >=10cm from walls, locomotor time 10.50.51.8-0.6-0.70.4-0.6-0.4-0.4-0.50.5-0.8-0.01.31.3
Bouts of movement, locomotor time 10.20.31.0-0.3-0.40.1-0.4-0.0-0.1-0.00.3-0.9-0.50.91.0
Total resting periods, locomotor time 10.20.20.6-0.1-0.1-0.2-0.10.30.20.3-0.0-0.7-0.70.70.8
Rest time, locomotor task time 10.30.41.50.30.2-0.50.10.60.60.6-0.2-0.8-1.20.80.9
Distance moved, locomotor task time 10.10.21.0-0.1-0.40.5-0.2-0.6-0.7-0.40.40.11.0-0.1-0.3
Vertical activity count, locomotor time 10.41.03.7-0.7-0.81.1-0.6-1.2-1.4-1.00.9-0.21.9-0.3-0.5
Time >=10cm from walls, locomotor time 20.20.30.50.70.5-0.70.70.70.70.5-0.70.5-0.60.00.0
Bouts of movement, locomotor time 20.50.81.11.01.0-1.00.91.00.91.0-0.90.9-0.9-0.7-0.6
Total resting periods, locomotor time 20.61.11.41.01.2-1.11.01.11.11.1-1.11.0-1.2-0.8-0.6
Rest time, locomotor task time 20.60.82.00.70.8-1.00.81.11.01.1-0.90.3-1.4-0.10.0
Distance moved, locomotor task time 20.91.03.5-0.6-1.11.1-0.7-1.2-1.2-1.20.9-0.51.90.3-0.0
Vertical activity count, locomotor time 21.11.53.7-1.1-1.21.3-1.0-1.4-1.5-1.41.2-0.61.90.30.1
Light reinforcement 11.84.47.2-1.8-2.12.5-2.3-2.6-2.4-2.62.3-1.22.70.70.5
Light reinforcement 22.13.24.3-2.0-1.82.0-1.8-2.0-2.1-1.81.9-1.52.11.11.0
Bone: marrow area0.10.10.5-0.5-0.10.20.0-0.3-0.3-0.20.2-0.00.7-0.4-0.5
Bone: maximum diameter0.30.61.7-0.8-0.50.9-0.6-0.9-0.8-1.00.8-0.41.3-0.1-0.3
Bone: maximum force0.30.61.30.70.8-0.60.80.50.60.5-0.71.0-0.0-1.1-1.1
Bone: maximum moment0.10.10.40.10.2-0.20.40.10.10.1-0.20.30.3-0.6-0.6
Mean time between licks in bursts0.10.10.5-0.2-0.10.20.1-0.2-0.40.30.10.00.7-0.5-0.6
Mean num. licks in bursts0.10.21.00.10.3-0.20.50.0-0.00.0-0.20.20.7-0.9-1.0
Cd content in liver0.10.10.30.50.2-0.20.30.10.30.4-0.20.30.1-0.4-0.6
Co content in liver0.20.20.80.30.2-0.30.60.10.20.2-0.30.30.5-0.6-0.9
Cu content in liver1.01.22.41.50.9-1.11.01.11.21.0-1.11.0-1.0-0.9-0.9
Fe content in liver1.82.22.9-1.7-1.71.5-1.4-1.5-1.6-1.71.5-1.51.51.21.0
K content in liver0.10.10.40.10.2-0.40.30.50.40.4-0.4-0.1-0.60.30.3
Mg content in liver0.50.51.2-0.7-0.70.6-0.7-0.5-0.6-0.70.6-0.90.21.11.1
Mn content in liver0.80.91.6-1.1-1.00.8-0.9-0.8-1.1-0.70.9-1.30.61.01.1
Na content in liver0.30.41.4-1.0-0.6-0.10.10.1-0.2-0.0-0.0-0.7-0.21.21.1
Rb content in liver0.40.51.71.30.6-0.60.50.60.70.6-0.50.3-0.6-0.9-0.8
Se content in liver0.60.83.60.70.4-0.20.70.0-0.20.2-0.30.61.0-1.7-1.9
Sr content in liver0.80.71.2-0.7-0.71.0-1.1-1.0-0.8-1.01.0-0.60.70.30.3
Zn content in liver2.12.33.51.91.5-1.51.81.41.41.4-1.61.5-0.6-1.7-1.8
Bone: minimum diameter0.20.31.4-0.4-0.30.4-0.1-0.6-0.6-0.60.4-0.41.2-0.5-0.7
Time in familiar zone, hab. session 10.40.30.8-0.7-0.70.5-0.4-0.6-0.8-0.10.6-0.90.80.30.1
Time in novel zone, hab. session 10.20.20.40.60.5-0.50.50.50.60.2-0.50.6-0.4-0.4-0.4
Total zone transitions, hab. session 10.71.01.7-0.9-1.01.1-1.3-1.0-0.8-1.31.1-0.80.31.11.1
Total locomotion distance, hab. session 10.81.22.4-1.0-1.01.3-1.3-1.2-0.9-1.51.2-0.80.80.80.8
Locomotion velocity, hab. session 11.01.52.9-1.1-1.11.4-1.6-1.3-0.9-1.71.3-0.80.71.01.0
Time in familiar zone, hab. session 21.11.12.5-1.1-1.10.9-0.7-1.0-1.3-0.71.1-1.61.40.60.4
Time in novel zone, hab. session 24.04.14.92.12.1-2.22.12.22.12.0-2.22.1-2.1-1.4-1.2
Total zone transitions, hab. session 21.62.14.0-1.4-1.31.7-2.0-1.5-1.3-1.71.6-1.00.61.31.4
Total locomotion distance, hab. session 20.81.01.9-0.9-0.91.3-1.3-1.2-0.8-1.41.2-0.60.80.50.5
Locomotion velocity, hab. session 20.70.92.0-0.8-0.81.3-1.4-1.2-0.7-1.41.1-0.40.60.60.6
Novel to familiar place preference ratio1.31.52.41.21.2-1.51.31.51.21.5-1.30.7-1.5-0.5-0.2
Novelty place preference2.22.43.51.61.6-1.81.71.91.61.8-1.71.0-1.9-0.7-0.4
Time in novel zone, NPP test2.02.13.21.51.5-1.81.71.81.51.7-1.60.9-1.6-0.8-0.5
Total zone transitions, NPP test1.42.03.3-1.5-1.41.6-1.8-1.6-1.3-1.71.6-0.90.91.21.2
Total locomotion distance, NPP test0.60.81.7-0.9-0.81.2-1.2-1.1-0.8-1.31.0-0.30.70.50.5
Locomotion velocity, NPP test0.50.71.5-0.8-0.71.1-1.2-1.0-0.7-1.20.9-0.10.70.40.4
Intraocular pressure0.81.22.81.21.1-0.70.90.60.80.8-0.81.5-0.2-1.6-1.7
Delta distance traveled before/after self-admin0.40.51.60.60.5-0.80.50.90.80.8-0.6-0.0-1.30.10.2
Delta ambulatory time before/after self-admin0.81.02.71.10.8-1.20.81.21.21.0-1.0-0.0-1.60.20.3
Parametrial fat weight6.515.319.3-4.2-4.44.1-4.1-4.0-4.2-4.04.1-3.73.53.43.1
Pavlov. Cond. lever latency0.10.10.6-0.4-0.40.1-0.0-0.2-0.40.00.3-0.80.40.30.2
Pavlov. Cond. magazine entry latency1.11.53.31.11.4-0.91.00.81.00.5-1.01.8-0.5-1.8-1.7
Pavlov. Cond. change in total contacts0.80.91.50.91.1-0.80.70.90.90.8-0.91.2-1.1-0.9-0.7
Pavlov. Cond. index score0.70.92.80.91.2-0.60.50.61.00.4-0.81.7-0.8-1.3-1.1
Pavlov. Cond. latency score0.60.82.30.81.1-0.50.50.50.90.3-0.71.5-0.6-1.2-1.0
Pavlov. Cond. lever contacts0.60.81.80.91.0-0.70.60.71.00.6-0.81.4-1.0-0.8-0.7
Pavlov. Cond. magazine entry number1.11.32.9-1.1-1.30.9-1.0-0.9-1.1-0.61.1-1.70.61.51.4
Pavlov. Cond. intertrial magazine entries0.30.31.9-0.4-0.40.40.1-0.5-0.6-0.40.4-0.61.4-0.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.70.92.70.91.2-0.60.50.71.00.4-0.81.7-0.9-1.2-1.0
Pavlov. Cond. response bias0.50.71.90.81.0-0.60.50.60.80.3-0.71.4-0.6-1.0-0.9
Pavlov. Cond. lever latency1.41.93.5-1.4-1.61.3-1.3-1.3-1.3-1.31.4-1.91.21.31.1
Pavlov. Cond. magazine entry latency3.84.66.22.22.5-2.02.22.02.12.0-2.12.4-1.5-2.3-2.2
Pavlov. Cond. change in total contacts2.13.46.71.72.1-1.51.71.51.51.7-1.82.6-1.1-2.3-2.1
Pavlov. Cond. index score3.64.87.32.22.6-2.12.22.12.12.1-2.22.7-1.8-2.3-2.0
Pavlov. Cond. latency score3.64.76.92.22.6-2.12.12.12.22.1-2.22.6-1.9-2.1-1.8
Pavlov. Cond. lever contacts1.92.65.01.61.9-1.51.51.51.51.4-1.62.2-1.4-1.6-1.3
Pavlov. Cond. magazine entry number5.67.09.2-2.7-3.02.6-2.7-2.5-2.6-2.62.7-2.91.82.82.6
Pavlov. Cond. intertrial magazine entries3.85.78.5-2.5-2.42.6-2.4-2.6-2.7-2.92.5-2.12.61.51.2
Pavlov. Cond. lever-magazine prob. diff.4.15.47.52.42.7-2.32.42.22.22.2-2.42.7-1.8-2.4-2.1
Pavlov. Cond. response bias3.34.57.62.12.5-2.02.11.92.01.9-2.22.7-1.5-2.3-2.1
Time in closed arm before self-admin3.03.85.7-2.1-2.02.0-2.4-1.9-1.8-1.92.1-1.70.82.22.1
Time in closed arm after self-admin3.63.85.5-1.9-1.92.0-2.3-1.8-1.8-2.02.0-1.90.82.22.3
Time in open arm before self-admin2.32.64.51.81.7-1.31.61.31.41.2-1.62.1-0.6-2.1-1.9
Time in open arm after self-admin0.80.92.30.60.7-0.81.20.60.70.6-0.91.10.4-1.3-1.5
Bone: periosteal estimation0.30.52.1-0.6-0.40.7-0.4-0.8-0.8-0.80.6-0.11.4-0.5-0.8
Bone: periosteal perimeter0.50.92.5-0.6-0.71.1-0.8-1.2-1.1-1.31.0-0.31.6-0.2-0.4
Bone: post-yield work0.71.01.6-0.8-1.20.9-0.9-0.9-0.9-1.01.0-1.30.81.11.0
Progressive ratio test 1 active lever presses3.44.25.92.42.2-2.22.22.12.21.9-2.11.7-1.5-2.0-2.0
Progressive ratio test 1 breakpoint3.13.85.42.32.1-2.02.12.02.11.8-2.01.6-1.5-1.9-1.9
Progressive ratio test 1 inactive lever presses0.10.10.40.30.3-0.50.30.50.40.3-0.3-0.4-0.60.30.3
Progressive ratio test 2 active lever presses2.42.84.02.01.7-2.01.82.02.01.8-1.70.7-1.8-0.8-0.8
Progressive ratio test 2 breakpoint2.52.94.02.01.7-2.01.92.02.01.9-1.80.7-1.9-0.8-0.8
Progressive ratio test 2 inactive lever presses0.10.10.20.20.2-0.50.50.40.30.4-0.3-0.4-0.2-0.0-0.1
Incentive Sensitization - Responses0.81.12.31.20.9-1.21.01.31.31.2-1.00.1-1.50.10.1
Incentive Sensitization - Breakpoint1.01.32.71.31.0-1.31.11.41.41.4-1.10.2-1.70.00.1
Sum of active levers in priming session hrs 5-60.30.30.60.80.5-0.40.60.40.5-0.0-0.50.3-0.1-0.7-0.7
Progressive ratio0.30.51.70.50.40.5-0.3-0.5-0.3-0.50.11.30.5-1.2-1.0
Food seeking constrained by brief footshock1.41.72.91.21.4-1.21.11.31.51.3-1.41.7-1.5-1.0-0.8
Seeking ratio, punishment vs. effort0.60.81.90.30.4-1.10.91.21.11.3-1.00.1-1.40.40.4
Retroperitoneal fat weight6.126.031.4-5.6-5.45.4-5.1-5.5-5.6-5.35.4-4.95.33.83.2
Reaction time number correct1.02.03.31.81.5-1.61.61.51.51.2-1.51.2-1.3-1.0-0.9
Reaction time mean minus median0.81.93.51.81.6-1.01.10.91.30.9-1.11.8-0.6-1.9-1.8
Reaction time mean minus median AUC0.71.83.71.91.4-0.81.00.81.20.7-1.01.9-0.4-1.9-1.9
Reaction time num false alarms0.10.20.40.70.1-0.40.20.40.50.4-0.3-0.1-0.70.30.3
Reaction time num false alarms AUC0.10.10.30.4-0.2-0.0-0.20.10.2-0.10.1-0.4-0.40.60.6
Reaction time trials correct on left1.02.03.31.81.5-1.61.61.51.51.2-1.51.2-1.3-1.0-0.9
Reaction time trials on left1.12.13.61.91.6-1.61.61.61.61.2-1.61.2-1.3-1.1-1.0
Reaction time mean0.10.20.70.30.20.2-0.1-0.20.0-0.10.00.80.3-0.7-0.8
Reaction time mean AUC0.10.20.90.60.4-0.10.10.10.30.2-0.20.9-0.0-0.8-0.8
Median of all reaction times0.10.20.3-0.2-0.30.6-0.5-0.6-0.4-0.40.40.30.6-0.2-0.2
Reaction time omissions0.10.20.60.60.30.2-0.1-0.2-0.1-0.40.10.60.3-0.8-0.7
Reaction time false alarm rate0.40.61.0-0.6-1.00.7-0.9-0.7-0.5-0.60.8-0.90.41.00.9
Reaction time premature initiation rate1.21.62.60.81.4-1.21.31.21.31.2-1.41.6-0.9-1.5-1.4
Reaction time premature initiations2.24.04.81.82.2-2.12.12.02.11.8-2.22.2-1.6-2.0-1.8
Std. dev. reaction times0.30.51.30.90.8-0.30.40.20.60.3-0.41.10.0-1.1-1.1
Reaction time trials completed1.12.13.61.91.6-1.61.61.61.61.2-1.61.2-1.3-1.1-1.0
Reaction time trials AUC1.12.13.61.91.6-1.61.61.61.51.2-1.61.3-1.3-1.1-1.0
Run reversals in cocaine runway, females1.51.52.6-1.6-1.21.2-1.1-1.3-1.3-1.21.2-1.31.40.90.6
Run reversals in cocaine runway, males0.20.20.3-0.6-0.50.5-0.5-0.5-0.6-0.40.5-0.40.40.20.1
Latency to leave start box in cocaine runway0.10.10.30.10.1-0.40.40.40.30.5-0.40.1-0.50.0-0.0
Latency to leave start box in cocaine runway, F0.91.11.90.90.8-1.41.21.41.11.3-1.1-0.1-1.30.10.1
Latency to leave start box in cocaine runway, M1.21.11.8-1.2-1.11.3-1.2-1.3-1.2-1.11.10.01.2-0.0-0.2
Std. dev. time between licks in bursts1.62.13.3-1.5-1.51.7-1.5-1.7-1.6-1.61.6-0.91.80.70.6
Total sessions with >9 infusions1.82.23.41.61.5-1.61.91.51.41.4-1.51.0-0.7-1.6-1.7
Short access day 1 total inactive lever presses0.10.10.3-0.1-0.1-0.10.3-0.0-0.10.20.0-0.60.5-0.2-0.3
Short access day 10 total inactive lever presses0.10.30.6-0.5-0.50.5-0.6-0.5-0.5-0.30.6-0.60.10.80.8
Short access day 1 total infusions0.40.61.01.00.6-0.91.00.90.90.8-0.8-0.1-0.5-0.4-0.6
Short access day 10 total infusions0.40.61.41.20.6-0.90.80.90.90.9-0.7-0.1-0.7-0.3-0.4
Short access total infusions2.02.53.71.91.5-1.81.91.81.81.7-1.60.9-1.3-1.3-1.3
Short access day 1 locomotion0.20.30.50.40.6-0.70.70.60.70.3-0.60.3-0.4-0.4-0.4
Short access day 10 total locomotion1.52.84.8-1.7-1.81.6-1.4-1.7-1.8-1.81.8-2.22.01.30.9
Short access total locomotion0.30.41.2-0.6-0.70.5-0.4-0.5-0.6-0.80.6-1.10.90.40.2
One hour access (0.3 mA shock)1.31.52.41.51.3-1.41.21.41.51.4-1.20.5-1.5-0.6-0.5
Compulsive drug intake0.10.20.4-0.6-0.30.5-0.3-0.5-0.5-0.40.30.00.6-0.1-0.1
One hour access (shock baseline)1.11.72.91.71.2-1.51.31.61.61.5-1.20.2-1.7-0.2-0.2
Social response proportion0.70.71.41.00.8-1.01.01.01.01.2-0.90.1-0.8-0.6-0.6
Social responses0.10.10.20.30.2-0.20.30.10.20.2-0.20.00.2-0.4-0.5
Social time0.10.20.70.70.2-0.30.50.20.20.4-0.2-0.20.4-0.6-0.8
Soleus weight0.20.61.3-1.2-0.70.8-0.7-0.9-0.8-0.80.8-0.41.00.20.1
Bone: stiffness3.55.68.02.72.6-2.22.22.22.32.2-2.32.8-1.8-2.6-2.3
Tibialis anterior weight0.51.53.71.81.2-0.80.70.81.30.6-1.01.9-0.9-1.5-1.5
Time to tail flick, vehicle, before self-admin0.50.50.90.60.8-0.90.90.90.90.6-0.80.3-0.7-0.5-0.4
Time to tail flick, vehicle, after self-admin0.60.82.0-0.6-0.90.8-0.8-0.8-0.9-0.81.0-1.40.90.80.6
Time to tail flick, test, before self-admin2.52.53.9-1.5-1.81.7-2.0-1.6-1.5-1.31.8-1.50.91.71.7
Time to tail flick, test, after self-admin0.10.10.30.1-0.10.1-0.0-0.2-0.2-0.10.2-0.10.4-0.4-0.5
Delta time to tail flick, vehicle, before/after SA0.60.61.9-0.4-0.70.8-0.5-0.9-1.0-0.70.8-0.81.40.0-0.3
Delta time to tail flick, test, before/after SA1.41.42.61.01.3-1.21.41.00.90.9-1.21.3-0.4-1.6-1.6
Tibia length0.00.10.40.20.5-0.10.10.20.20.2-0.20.7-0.3-0.5-0.4
Ambulatory time before self-admin1.31.94.7-1.8-1.11.6-1.2-1.7-1.8-1.41.30.02.2-0.0-0.1
Ambulatory time after self-admin0.50.51.5-1.2-0.60.8-0.7-0.8-0.9-0.70.7-0.30.70.50.7
Bone: tissue strength0.40.40.9-0.7-0.1-0.60.50.60.20.7-0.3-0.8-0.50.80.9
Total heroin consumption0.80.91.70.90.8-1.21.11.21.30.9-1.10.5-1.2-0.4-0.4
Bone: trabecular number0.30.50.8-0.6-0.70.8-0.9-0.8-0.9-0.70.8-0.60.60.50.4
Bone: trabecular spacing0.00.00.1-0.2-0.30.1-0.1-0.2-0.2-0.20.1-0.10.30.10.1
Bone: trabecular thickness0.50.71.11.00.9-0.70.70.60.70.8-0.81.0-0.5-1.0-0.9
Bone: trabecular tissue density0.50.81.60.70.9-1.00.81.01.11.0-0.90.8-1.3-0.4-0.2
Water consumed over 24 hours0.20.30.7-0.5-0.40.6-0.8-0.5-0.4-0.70.6-0.20.00.50.6
Number of responses in last shaping day0.60.71.50.70.9-0.60.70.60.70.4-0.81.2-0.4-1.2-1.1