Hub : Genes

Tsbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Tsbp1 0.02 0.01 8.8e-03 0.01 0.01 0.01 0.01 2.5e-02 1.4e-02 2.1e-02 4.1e-02
2 PL alternative TSS XM_063279451.1 0.02 0.02 1.9e-03 0.02 0.02 0.02 0.01 3.8e-03 2.8e-03 6.0e-03 2.8e-02
3 Brain alternative polyA XM_063279453.1 0.04 0.04 9.2e-03 0.03 0.02 0.01 0.02 7.1e-04 1.1e-02 2.6e-02 7.2e-03
4 LHb gene expression Tsbp1 0.17 0.1 6.7e-03 0.03 0.04 -0 0.03 7.2e-02 3.2e-02 4.2e-01 6.8e-02
5 NAcc alternative TSS XM_063279451.1 0.03 0.01 3.2e-04 0.02 0.02 0.02 0.01 2.1e-04 2.9e-04 1.2e-03 1.8e-03
6 Brain alternative TSS XM_063279451.1 0.03 0.02 3.9e-03 0.02 0.03 0.02 0.02 3.8e-03 7.1e-04 8.1e-03 2.5e-03
7 Brain isoform ratio XM_063279451.1 0.1 0.05 1.0e-07 0.09 0.1 0.09 0.09 2.2e-08 2.7e-09 1.3e-08 5.8e-09
8 NAcc gene expression Tsbp1 0.02 0.01 2.2e-03 0.01 0.01 0.01 0.01 7.7e-03 4.2e-03 2.3e-02 1.3e-02
9 LHb alternative TSS XM_063279451.1 0.16 0.09 1.9e-03 0.1 0.07 0.12 0.04 2.4e-03 9.8e-03 9.9e-04 4.4e-02
10 Adipose gene expression Tsbp1 0.23 0.12 1.1e-09 0.06 0.07 0.07 0.08 2.1e-07 2.7e-08 4.5e-08 1.7e-09
11 Adipose alternative TSS XM_063279451.1 0.17 0.09 6.6e-10 0.05 0.08 0.08 0.08 3.3e-06 1.9e-09 4.1e-09 1.3e-09
12 Adipose isoform ratio XM_063279451.1 0.23 0.1 4.0e-15 0.09 0.12 0.12 0.12 1.3e-10 9.6e-13 3.4e-13 3.6e-13
13 Adipose alternative polyA XM_063279453.1 0.07 0.04 1.7e-04 0.05 0.03 0.03 0.04 2.9e-06 3.7e-04 3.5e-04 2.6e-05
14 BLA alternative TSS XM_063279451.1 0.06 0.04 6.5e-03 0.03 0.05 0.02 0.03 8.2e-03 1.6e-03 3.5e-02 1.7e-02
15 Brain gene expression Tsbp1 0.04 0.03 3.4e-03 0.03 0.02 0.02 0.02 1.6e-03 4.8e-03 9.6e-03 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.02.9-1.71.3-1.2-1.0-0.61.50.5-0.7-1.4-0.90.7-0.6-0.2-0.11.1
Area under the delay curve0.20.31.40.8-0.60.80.30.0-0.5-0.30.30.30.1-0.10.0-0.30.51.2
BMI with tail1.34.710.32.0-2.22.32.62.2-2.5-2.92.92.5-0.70.5-0.40.1-3.2-2.0
BMI without tail1.15.69.53.1-3.02.63.03.0-3.0-2.82.82.8-1.01.2-1.1-0.8-1.4-1.5
Body weight2.29.717.33.9-3.73.43.63.5-4.2-3.33.73.90.9-0.90.91.1-3.0-3.1
Weight adjusted by age0.51.43.11.7-1.31.31.01.1-1.4-0.61.31.70.9-0.80.80.8-0.6-1.8
Bone surface0.10.20.5-0.40.4-0.7-0.30.00.20.3-0.5-0.00.7-0.70.60.6-0.1-0.1
Bone volume0.00.10.2-0.50.3-0.3-0.10.30.3-0.1-0.2-0.3-0.1-0.0-0.00.1-0.30.4
Breakpoint value in progressive ratio session0.10.30.7-0.60.6-0.8-0.5-0.50.50.5-0.7-0.20.4-0.50.40.50.40.4
Number of licking bursts0.41.12.0-0.91.0-1.1-0.9-0.90.61.1-1.3-0.51.4-1.41.41.30.60.3
Context. condit. distance diff. score6.57.812.0-3.43.5-3.5-3.2-3.03.03.0-3.0-2.62.4-2.52.52.80.91.5
Locomotion velocity, session 11.71.93.5-1.31.5-1.5-1.7-1.21.61.9-1.8-1.50.4-0.40.30.01.91.4
Locomotion distance, session 10.70.92.1-1.41.2-1.3-1.0-0.91.30.7-0.9-1.2-0.60.4-0.4-0.20.20.9
Locomotion velocity, session 20.50.61.2-0.80.8-0.8-0.8-1.10.70.7-1.0-0.90.5-0.50.60.40.60.8
Locomotion distance, session 20.81.13.1-1.51.4-1.2-1.2-1.81.20.9-0.8-1.20.4-0.50.60.9-0.40.5
Locomotion velocity, session 30.50.51.50.5-0.60.50.60.5-0.4-0.60.30.2-1.11.2-1.2-1.20.40.4
Locomotion distance, session 31.21.42.4-1.61.4-1.4-1.2-1.51.51.0-1.2-1.5-0.40.4-0.4-0.10.81.4
Stereotopy head waving bouts, day 30.60.71.41.1-0.80.60.60.7-1.0-0.20.31.21.0-1.00.90.7-0.0-1.2
Stereotopy head waving duration, day 30.40.51.61.3-0.90.80.61.0-1.0-0.20.40.90.4-0.30.2-0.00.4-0.7
Locomotion velocity, session 73.23.57.9-2.82.6-2.2-2.3-2.62.51.7-1.5-2.30.5-0.70.81.4-0.21.2
Locomotion distance, session 73.74.89.4-3.02.8-2.5-2.7-2.73.12.3-2.2-2.9-0.0-0.10.20.61.12.2
Stereotopy head waving bouts, day 70.60.72.80.8-0.70.50.30.5-0.3-0.1-0.3-0.0-0.80.9-0.9-1.21.71.2
Stereotopy head waving duration, day 70.50.61.41.2-1.00.80.80.7-0.8-0.50.30.7-0.60.7-0.8-1.00.90.2
Locomotion velocity, session 83.13.76.0-1.51.9-2.1-2.0-2.31.42.3-2.2-1.12.5-2.42.32.11.20.6
Locomotion distance, session 85.78.313.7-3.73.6-3.7-3.2-3.53.12.9-2.8-2.62.3-2.52.63.00.11.0
Degree of sensitization distance0.70.71.7-0.60.7-0.7-0.8-0.60.50.9-0.7-0.11.3-1.21.31.20.1-0.4
Degree of sensitization stereotypy0.70.83.20.00.0-0.1-0.2-0.10.30.2-0.8-0.7-0.91.0-1.0-1.21.71.8
Conditioned locomotion0.70.92.00.5-0.50.50.70.7-0.9-0.60.61.01.1-1.21.11.0-1.3-1.4
Cocaine response after cond. corrected0.60.93.3-0.80.7-0.6-0.3-0.40.20.10.10.11.2-1.31.41.8-1.6-1.1
Cocaine response after cond. not corrected0.50.82.20.2-0.10.00.2-0.0-0.6-0.10.10.81.4-1.41.41.5-0.9-1.2
Cocaine response before conditioning1.51.85.62.4-2.01.61.51.4-1.9-0.80.71.80.10.0-0.3-0.91.1-0.6
Saline control response4.86.611.63.1-3.13.32.83.4-2.6-2.72.72.2-2.22.3-2.4-2.6-0.5-0.9
Bone: connectivity density0.50.82.6-1.61.3-1.3-0.9-0.81.20.6-0.6-1.1-0.1-0.20.20.6-0.70.3
Bone: cortical apparent density1.62.54.31.6-1.81.61.91.8-1.7-2.12.01.6-1.21.1-1.1-1.1-1.5-1.2
Bone: cortical area0.10.10.30.5-0.40.30.50.5-0.6-0.40.20.30.00.0-0.1-0.1-0.10.1
Bone: cortical porosity1.51.78.00.4-0.1-0.4-0.50.10.50.7-1.0-0.9-1.21.4-1.5-1.92.82.2
Bone: cortical porosity1.31.47.70.20.2-0.7-0.8-0.20.61.1-1.2-1.0-0.60.8-0.9-1.32.82.0
Bone: cortical thickness1.22.03.61.1-1.41.31.61.6-1.2-1.81.40.7-1.91.8-1.8-1.6-0.70.2
Bone: cortical thickness2.53.15.61.7-2.01.92.21.9-1.8-2.42.01.4-1.71.5-1.6-1.3-1.4-0.8
Bone: cortical tissue density1.52.34.01.6-1.81.51.91.7-1.6-2.01.91.5-1.11.0-1.1-1.0-1.4-1.2
Condit. Reinf. active minus inactive responses0.70.82.5-0.50.5-0.4-0.9-1.10.91.0-0.8-0.9-0.70.7-0.7-0.91.60.9
Condit. Reinf. active-inactive response ratio0.60.61.60.9-0.90.60.70.4-0.5-0.50.60.5-1.21.2-1.1-1.30.5-0.3
Condit. Reinf. active responses0.40.61.5-0.80.7-0.4-0.8-1.21.00.8-0.6-0.8-0.60.5-0.6-0.60.80.5
Condit. Reinf. inactive responses0.60.82.1-1.41.1-0.7-1.0-1.31.40.6-0.6-1.1-0.60.5-0.5-0.30.00.8
Incentive salience index mean1.82.35.2-1.71.8-1.6-1.9-2.31.81.9-1.7-1.80.7-0.70.70.71.11.1
Condit. Reinf. lever presses3.75.68.8-2.93.0-2.8-2.7-2.92.42.5-2.4-2.32.1-2.12.22.40.21.0
Condit. Reinf. active minus inactive responses0.20.31.11.1-0.80.50.50.6-0.7-0.30.30.7-0.00.2-0.3-0.50.6-0.2
Condit. Reinf. active-inactive response ratio0.20.30.90.9-0.60.40.20.4-0.60.20.10.70.6-0.40.40.10.7-0.5
Condit. Reinf. active responses0.10.20.50.5-0.40.20.30.4-0.3-0.10.10.3-0.40.5-0.6-0.70.6-0.1
Condit. Reinf. inactive responses0.20.40.80.4-0.50.40.60.4-0.4-0.80.50.2-0.90.8-0.9-0.8-0.30.0
Condit. Reinf. lever presses0.60.92.3-0.60.6-0.9-0.8-0.61.00.8-0.9-1.2-0.80.9-0.8-1.01.51.5
Condit. Reinf. lever reinforcers received0.10.20.90.4-0.3-0.00.00.1-0.10.2-0.20.1-0.40.5-0.6-0.81.00.2
Conditioned reinforcement - actives0.00.00.1-0.10.0-0.1-0.1-0.00.20.00.2-0.1-0.1-0.1-0.10.1-0.0-0.2
Conditioned reinforcement - inactives0.00.00.20.1-0.10.5-0.20.00.20.20.2-0.2-0.1-0.1-0.1-0.30.30.0
Conditioned locomotion0.10.20.5-0.30.4-0.4-0.6-0.40.50.7-0.2-0.30.3-0.30.20.70.30.0
Patch foraging indifference point 0 sec1.23.56.42.5-2.52.22.32.1-2.1-2.12.32.1-1.11.2-1.3-0.9-0.6-1.0
Patch foraging indifference point AUC0.10.30.80.7-0.60.30.40.4-0.5-0.1-0.10.6-0.40.7-0.7-0.40.9-0.1
Delay disc. indifference point, 0s delay0.40.41.3-0.20.4-0.3-0.5-0.80.20.5-0.3-0.21.0-1.11.11.0-0.00.7
Delay disc. indifference point, 16s delay0.40.51.60.7-0.70.90.50.4-0.4-0.60.60.2-0.90.9-0.9-1.30.31.0
Delay disc. indifference point, 2s delay0.40.51.40.6-0.20.5-0.2-0.3-0.20.6-0.20.41.2-1.11.00.61.00.8
Delay disc. indifference point, 24s delay0.40.61.81.3-1.00.90.50.6-0.6-0.30.50.5-0.50.6-0.7-1.31.10.5
Delay disc. indifference point, 4s delay0.80.82.21.5-1.31.41.00.8-1.3-0.80.71.30.4-0.30.30.10.30.2
Delay disc. indifference point, 8s delay0.10.21.80.4-0.30.50.0-0.2-0.1-0.00.2-0.2-0.20.2-0.3-0.30.51.4
Indifference point function ln k0.20.71.1-0.70.8-0.8-0.8-1.00.70.9-1.0-0.80.9-1.10.90.40.80.7
Indifference point function log k0.20.71.1-0.70.8-0.8-0.8-1.00.70.9-1.0-0.80.9-1.10.90.40.80.7
Patch foraging total patch changes 0 sec1.33.76.62.5-2.62.32.32.2-2.2-2.22.32.0-1.31.4-1.4-1.1-0.6-0.8
Patch foraging total patch changes 12 sec2.02.64.32.0-2.11.71.91.9-1.8-1.71.71.9-1.31.5-1.5-1.2-0.3-1.2
Patch foraging total patch changes 18 sec1.43.35.81.7-2.11.62.21.9-1.8-2.42.31.4-1.91.9-1.8-1.0-1.6-0.6
Patch foraging total patch changes 24 sec0.41.23.70.5-0.81.10.80.7-0.3-1.11.1-0.1-1.91.9-1.8-1.2-0.40.7
Patch foraging total patch changes 6 sec1.93.25.92.2-2.22.42.01.8-1.8-1.92.11.6-1.71.8-1.8-1.1-0.5-0.6
Patch foraging time to switch 0 sec0.31.06.40.1-0.40.50.90.5-0.7-1.31.40.5-0.2-0.20.30.4-2.5-1.7
Patch foraging water rate 0 sec0.10.30.80.9-0.70.90.50.5-0.7-0.30.60.60.10.1-0.0-0.2-0.2-0.1
Patch foraging water rate 12 sec0.10.30.80.0-0.20.10.30.5-0.0-0.60.3-0.4-0.90.9-0.8-0.7-0.10.7
Patch foraging water rate 18 sec0.20.51.20.9-0.91.10.80.7-0.8-0.80.90.6-0.40.5-0.5-0.4-0.5-0.0
Patch foraging water rate 24 sec0.20.30.70.5-0.60.50.70.8-0.5-0.80.60.5-0.40.3-0.4-0.6-0.4-0.0
Patch foraging water rate 6 sec0.20.30.60.5-0.60.70.70.6-0.6-0.80.70.7-0.40.4-0.3-0.7-0.6-0.3
Seeking ratio, delayed vs. immediate footshock1.42.03.81.9-2.01.11.91.9-1.8-1.60.91.7-0.80.9-1.0-1.00.3-0.3
Distance traveled before self-admin0.40.82.2-0.10.0-0.90.30.1-0.5-0.30.40.51.2-1.41.41.3-1.5-0.9
Distance traveled after self-admin0.81.43.01.5-1.40.81.51.4-1.7-1.21.01.70.5-0.40.40.2-0.7-1.5
Extensor digitorum longus weight0.20.82.5-0.50.6-0.7-0.6-0.40.30.7-0.5-0.31.6-1.51.61.6-0.20.1
Bone: elastic displacement0.50.61.70.3-0.30.20.10.40.1-0.10.2-0.3-1.31.3-1.2-1.30.90.9
Bone: elastic work0.10.20.50.6-0.60.30.40.7-0.4-0.40.50.2-0.40.4-0.3-0.40.10.2
Bone: endosteal estimation1.12.89.61.3-0.70.50.40.6-1.30.30.11.63.1-2.92.82.4-0.2-1.8
Bone: endosteal perimeter0.92.28.1-0.30.8-0.9-0.8-0.70.11.3-1.00.22.8-2.72.62.3-0.0-0.9
Epididymis fat weight2.914.828.72.9-3.83.94.54.1-3.4-5.45.12.8-4.03.8-3.5-2.2-4.6-2.3
Delta time in closed arm before/after self-admin0.30.20.70.3-0.20.10.20.2-0.5-0.20.50.60.4-0.40.40.8-0.9-0.8
Delta time in open arm before/after self-admin0.10.10.40.1-0.20.30.10.20.0-0.20.1-0.0-0.60.5-0.6-0.50.30.5
Diff in mean of infusions in LGA sessions0.81.53.6-1.91.7-1.4-1.4-1.81.51.1-1.2-1.50.3-0.40.50.9-0.30.8
Delay discount exponential model param0.20.31.3-0.90.7-0.9-0.3-0.10.50.2-0.3-0.4-0.10.00.00.3-0.7-1.1
Extinction: sum of active levers before priming0.60.81.7-0.80.9-0.8-0.9-1.20.71.0-0.8-0.41.2-1.21.21.30.2-0.3
Active lever presses in extinction session 60.20.21.1-0.40.3-0.2-0.5-0.30.60.30.1-0.6-0.60.5-0.5-0.30.11.0
Bone: final force2.13.55.62.0-2.12.22.22.1-2.3-2.22.42.2-0.10.00.10.4-2.1-2.1
Bone: final moment1.52.54.11.8-1.81.91.81.9-1.9-1.92.01.7-0.20.10.00.2-1.7-1.6
Food consumed during 24 hour testing period0.51.12.80.4-0.30.50.50.2-0.8-0.40.70.81.5-1.51.51.7-1.6-1.3
Glucose3.86.010.8-1.72.4-2.5-2.8-2.61.93.3-2.5-1.43.2-3.12.92.61.60.3
Heart weight0.71.23.61.9-1.51.80.91.1-1.3-0.50.91.5-0.20.4-0.5-0.80.70.2
Delay discount hyperbolic model param0.30.41.5-1.00.7-0.9-0.3-0.10.60.2-0.2-0.4-0.20.1-0.00.2-0.8-1.2
Intermittent access intake day 1-15 change0.00.20.50.5-0.50.20.50.4-0.4-0.40.20.1-0.50.7-0.7-0.70.2-0.3
Intermittent access intake escalation0.21.12.71.0-1.10.91.00.9-0.8-1.00.60.4-1.41.6-1.6-1.50.4-0.1
Intermittent access intake escalation 20.10.10.50.1-0.10.1-0.0-0.20.00.2-0.3-0.3-0.40.5-0.6-0.40.70.2
Intermitt. access day 1 inactive lever presses0.11.34.3-0.70.8-0.3-0.6-0.90.20.7-0.70.12.0-2.02.11.7-0.5-0.8
Intermitt. access day 15 inactive lever presses0.00.20.40.6-0.50.40.40.4-0.5-0.20.40.60.3-0.20.30.3-0.3-0.6
Intermitt. access escalation Index0.51.53.2-1.81.6-1.5-1.1-1.51.20.9-1.4-1.00.9-1.01.01.3-0.20.7
Intermittent access day 1 total infusions0.61.94.3-1.61.7-1.4-2.0-1.52.11.8-1.2-1.8-0.0-0.10.10.31.21.3
Intermittent access day 15 total infusions0.20.41.4-0.20.2-0.0-0.4-0.20.60.3-0.1-0.7-1.11.1-1.2-0.80.90.3
Intermittent access terminal intake (last 3 days)0.20.41.30.10.00.1-0.4-0.10.50.4-0.1-0.6-0.90.9-1.1-0.81.10.5
Intermittent access total infusions0.40.51.2-0.40.5-0.3-0.8-0.51.00.7-0.4-0.9-0.70.6-0.7-0.51.10.7
Intermittent access day 1 locomotion0.10.10.4-0.50.4-0.4-0.5-0.30.60.30.0-0.6-0.2-0.1-0.00.5-0.00.2
Intermittent access day 15 total locomotion0.20.71.41.1-1.00.80.91.0-1.0-0.81.11.0-0.20.2-0.3-0.1-0.5-1.2
Intermittent access total locomotion0.20.20.50.5-0.50.50.40.6-0.3-0.40.70.2-0.70.6-0.7-0.4-0.0-0.3
Intermittent access standard deviation0.52.85.72.0-2.02.41.92.1-1.8-1.81.91.5-1.01.2-1.3-0.7-0.9-1.4
Left kidney weight1.29.416.53.9-3.93.43.93.9-4.1-3.83.63.6-0.40.4-0.5-0.7-2.4-2.3
Right kidney weight1.38.915.53.6-3.63.13.73.7-3.9-3.63.63.7-0.00.0-0.1-0.3-2.9-2.7
Cocaine induced anxiety0.20.63.1-0.50.4-0.4-0.1-0.4-0.00.1-0.30.31.1-1.11.11.8-0.7-0.8
Post-drug Anxiety0.30.31.00.2-0.20.30.40.3-0.5-0.40.20.70.7-0.60.71.0-0.6-0.6
Baseline Anxiety0.10.20.90.7-0.60.50.40.5-0.5-0.30.50.3-0.30.3-0.3-0.90.10.2
Tail length0.52.68.02.8-2.11.51.41.7-2.3-0.50.82.21.7-1.31.20.51.0-1.1
Length with tail1.14.910.43.2-2.52.11.92.1-3.0-1.11.62.92.5-2.22.11.8-0.4-2.2
Length without tail1.26.410.62.4-2.01.92.12.0-2.9-1.82.53.02.6-2.62.62.6-3.1-3.3
Times rat made contact with spout1.31.54.80.2-0.40.50.3-0.00.2-0.50.2-0.6-2.12.2-2.2-2.21.01.4
Lifetime Intake0.20.30.9-0.30.4-0.2-0.7-0.40.80.7-0.2-0.7-0.40.4-0.5-0.40.90.4
Liver weight, left1.01.75.00.6-0.3-0.10.30.0-1.00.10.11.42.2-2.22.21.9-0.7-1.7
Liver weight, right1.32.38.40.30.2-0.3-0.4-0.6-0.40.8-0.41.02.9-2.82.82.5-0.1-1.0
Locomotor activity0.50.72.01.4-1.20.61.10.9-1.3-0.60.21.40.6-0.40.30.30.6-0.7
Locomotor testing distance0.20.61.50.8-0.60.10.70.3-0.9-0.40.11.00.9-0.80.81.2-0.0-1.2
Locomotor testing rearing0.31.22.90.8-0.70.50.80.6-1.1-0.60.61.31.3-1.31.31.6-0.9-1.7
Locomotion in novel chamber0.10.10.50.3-0.40.70.50.4-0.4-0.60.30.0-0.20.2-0.30.2-0.3-0.1
Locomotion in novel chamber post-restriction0.51.42.31.4-1.41.41.41.5-1.4-1.41.51.3-0.20.1-0.1-0.2-1.1-1.1
Fecal boli incidents, locomotor time 10.20.51.1-1.01.0-1.0-0.9-0.40.90.6-0.4-0.90.2-0.20.30.8-0.3-0.1
Change in fecal boli incidents, locomotor task0.80.92.10.9-0.60.60.50.1-1.0-0.10.21.41.4-1.31.30.8-0.2-1.4
Time >=10cm from walls, locomotor time 11.92.44.51.1-1.00.71.20.8-1.7-1.11.21.91.8-1.81.81.7-2.1-2.0
Bouts of movement, locomotor time 10.10.20.4-0.60.5-0.6-0.3-0.30.40.2-0.7-0.6-0.30.3-0.3-0.40.50.4
Total resting periods, locomotor time 10.20.20.5-0.60.5-0.7-0.4-0.30.50.4-0.7-0.7-0.20.3-0.2-0.30.50.3
Rest time, locomotor task time 10.20.30.6-0.50.6-0.7-0.6-0.30.50.6-0.8-0.80.4-0.30.40.40.60.5
Distance moved, locomotor task time 10.30.81.71.1-1.11.11.00.9-1.1-0.91.11.3-0.10.2-0.2-0.3-0.6-1.0
Vertical activity count, locomotor time 10.32.14.31.6-1.71.71.71.4-1.7-1.61.82.1-0.50.5-0.5-0.6-1.3-1.3
Time >=10cm from walls, locomotor time 20.41.32.51.5-1.10.80.80.8-1.4-0.51.11.41.3-1.21.20.8-0.8-1.6
Bouts of movement, locomotor time 20.00.20.90.4-0.40.40.30.4-0.3-0.1-0.30.1-0.30.3-0.4-0.60.9-0.2
Total resting periods, locomotor time 20.10.22.00.1-0.0-0.1-0.10.10.10.3-0.8-0.20.1-0.0-0.1-0.41.40.2
Rest time, locomotor task time 20.81.43.4-1.11.2-1.3-0.9-0.90.60.8-1.1-0.51.7-1.71.71.8-0.4-0.1
Distance moved, locomotor task time 21.01.43.11.4-1.31.51.11.1-1.0-1.01.71.1-0.91.1-1.0-0.8-0.9-1.2
Vertical activity count, locomotor time 20.41.02.41.3-1.21.41.00.9-1.1-0.91.61.2-0.40.5-0.5-0.3-0.8-1.0
Light reinforcement 10.41.75.70.9-1.01.01.40.8-1.4-1.41.51.60.3-0.30.40.3-2.3-2.4
Light reinforcement 20.40.83.10.3-0.30.70.60.0-0.8-0.50.90.90.7-0.60.81.1-1.8-1.6
Bone: marrow area1.22.99.31.5-0.80.70.50.7-1.50.10.31.73.0-2.82.72.3-0.3-1.9
Bone: maximum diameter0.71.43.4-0.71.1-1.0-1.2-1.20.61.4-1.3-0.61.9-1.81.61.40.60.2
Bone: maximum force0.81.62.51.4-1.41.41.41.5-1.5-1.41.61.50.2-0.30.30.5-1.5-1.5
Bone: maximum moment0.50.91.71.1-1.01.11.01.3-1.2-1.01.21.10.3-0.30.30.5-1.1-1.0
Mean time between licks in bursts0.53.25.0-1.61.9-2.2-1.9-1.41.52.1-2.2-1.42.0-2.01.91.71.31.0
Mean num. licks in bursts0.92.36.01.0-1.31.41.10.9-0.6-1.41.40.3-2.42.5-2.4-2.4-0.10.5
Cd content in liver0.30.42.3-0.50.40.1-0.3-0.00.40.10.70.0-0.0-0.10.20.7-1.5-1.1
Co content in liver1.51.83.31.3-1.41.61.41.4-1.4-1.41.81.6-0.50.4-0.5-0.2-1.6-1.7
Cu content in liver0.80.93.4-0.1-0.20.00.2-0.10.3-0.50.2-0.4-1.81.8-1.8-1.60.40.9
Fe content in liver0.60.81.50.7-0.91.01.01.1-0.8-1.21.20.7-0.70.7-0.6-0.5-1.0-0.7
K content in liver0.70.71.7-1.21.1-1.3-0.9-1.01.00.7-0.9-1.00.3-0.40.40.50.10.7
Mg content in liver2.32.54.7-1.81.8-2.2-1.6-1.91.41.6-1.8-1.01.7-1.71.71.60.40.2
Mn content in liver2.93.37.4-1.41.7-2.0-1.5-2.01.01.6-1.5-0.62.7-2.72.62.5-0.1-0.4
Na content in liver0.40.41.30.3-0.40.30.50.3-0.2-0.60.00.0-1.01.1-1.1-1.10.40.8
Rb content in liver0.50.51.2-0.90.9-0.6-0.7-0.60.70.6-0.3-0.50.8-0.90.91.1-0.5-0.3
Se content in liver1.82.24.4-1.11.4-1.4-1.6-2.11.22.0-2.1-1.01.5-1.31.20.81.80.7
Sr content in liver0.10.10.3-0.10.3-0.0-0.40.30.10.40.0-0.30.6-0.50.50.5-0.3-0.2
Zn content in liver0.40.40.8-0.50.6-0.7-0.6-0.70.40.8-0.3-0.10.8-0.90.80.9-0.2-0.7
Bone: minimum diameter0.71.34.9-0.00.4-0.6-0.4-0.5-0.20.8-0.50.32.2-2.12.11.9-0.2-0.7
Time in familiar zone, hab. session 11.51.64.8-0.60.3-0.3-0.3-0.11.0-0.1-0.2-1.2-2.22.1-2.1-1.90.91.8
Time in novel zone, hab. session 11.01.22.91.0-0.70.60.60.6-1.1-0.20.41.41.6-1.51.41.2-0.6-1.7
Total zone transitions, hab. session 10.30.41.0-1.00.9-1.0-0.7-0.70.80.6-0.9-0.60.1-0.20.30.30.30.5
Total locomotion distance, hab. session 10.40.61.5-1.21.1-1.1-0.8-0.80.90.5-0.9-0.90.3-0.30.50.5-0.00.6
Locomotion velocity, hab. session 10.20.30.8-0.90.8-0.8-0.6-0.60.70.4-0.8-0.70.1-0.20.30.30.20.6
Time in familiar zone, hab. session 20.70.81.60.6-0.90.41.21.0-0.8-1.30.70.8-1.21.1-1.0-1.0-0.4-0.3
Time in novel zone, hab. session 20.10.10.30.20.00.5-0.4-0.10.20.60.1-0.20.2-0.10.0-0.00.40.0
Total zone transitions, hab. session 20.20.21.2-0.50.2-0.40.2-0.2-0.1-0.40.00.20.3-0.40.50.7-1.1-0.4
Total locomotion distance, hab. session 20.60.82.3-1.51.2-1.1-0.6-1.00.80.2-0.6-0.70.5-0.70.81.1-1.10.2
Locomotion velocity, hab. session 21.01.33.4-1.81.5-1.6-0.9-1.41.10.5-1.0-1.10.7-0.81.01.2-0.80.5
Novel to familiar place preference ratio0.10.20.6-0.20.3-0.3-0.5-0.20.50.6-0.4-0.5-0.10.2-0.2-0.30.80.7
Novelty place preference0.10.20.9-0.10.2-0.2-0.4-0.20.40.6-0.4-0.4-0.10.2-0.2-0.40.90.6
Time in novel zone, NPP test0.10.21.10.10.0-0.0-0.3-0.00.30.5-0.4-0.3-0.10.3-0.2-0.51.00.6
Total zone transitions, NPP test1.32.04.4-2.11.9-2.0-1.6-1.71.81.3-1.4-1.60.4-0.60.70.90.10.9
Total locomotion distance, NPP test1.31.84.5-2.11.9-1.6-1.5-1.61.71.1-0.9-1.60.5-0.70.81.2-0.80.6
Locomotion velocity, NPP test1.82.56.5-2.52.2-2.0-1.8-2.02.01.2-1.2-1.90.6-0.80.91.4-0.80.8
Intraocular pressure0.10.20.7-0.20.00.20.10.60.2-0.30.4-0.1-0.90.7-0.7-0.5-0.40.2
Delta distance traveled before/after self-admin1.21.33.21.7-1.51.81.11.3-1.2-0.70.61.3-0.70.8-1.0-1.11.2-0.2
Delta ambulatory time before/after self-admin0.61.12.71.6-1.41.61.11.1-1.2-0.70.51.3-0.30.4-0.6-1.01.0-0.4
Parametrial fat weight1.73.910.51.5-1.92.42.41.9-2.1-2.72.71.8-0.80.7-0.5-0.1-3.2-1.9
Pavlov. Cond. lever latency6.27.912.43.0-3.33.33.53.1-3.2-3.53.53.2-1.61.5-1.5-1.2-2.5-2.5
Pavlov. Cond. magazine entry latency2.33.06.6-1.41.7-1.9-1.9-2.01.82.1-2.4-1.90.6-0.40.40.12.62.1
Pavlov. Cond. change in total contacts1.11.23.3-0.81.0-1.1-1.3-1.31.11.5-1.6-0.90.7-0.50.50.21.81.1
Pavlov. Cond. index score4.75.99.6-2.42.7-2.8-2.9-2.82.63.0-3.1-2.71.5-1.31.31.02.52.4
Pavlov. Cond. latency score4.96.210.3-2.52.8-2.9-3.0-2.82.73.1-3.2-2.71.6-1.41.31.02.52.4
Pavlov. Cond. lever contacts5.56.69.9-2.83.1-3.1-3.1-2.92.83.1-3.0-2.72.0-1.91.91.81.71.8
Pavlov. Cond. magazine entry number1.72.24.51.3-1.51.61.71.6-1.6-1.82.01.6-0.60.5-0.4-0.2-2.1-1.7
Pavlov. Cond. intertrial magazine entries0.60.71.50.3-0.51.10.60.7-0.3-0.91.20.6-1.21.0-1.0-0.7-1.2-0.7
Pavlov. Cond. lever-magazine prob. diff.4.75.99.3-2.42.7-2.8-2.9-2.92.62.9-3.0-2.71.5-1.31.31.02.42.4
Pavlov. Cond. response bias3.23.96.5-2.02.2-2.3-2.4-2.42.12.5-2.6-2.11.2-1.11.10.82.11.8
Pavlov. Cond. lever latency0.60.82.2-0.00.1-0.10.00.0-0.40.10.10.61.5-1.51.51.5-0.9-1.2
Pavlov. Cond. magazine entry latency0.40.61.0-0.70.8-0.7-1.0-0.90.91.0-0.8-0.90.4-0.40.40.40.80.8
Pavlov. Cond. change in total contacts0.20.61.90.3-0.20.0-0.00.20.20.0-0.2-0.4-1.11.1-1.2-1.41.31.1
Pavlov. Cond. index score0.30.41.3-0.20.3-0.4-0.5-0.40.60.5-0.5-0.8-0.60.6-0.6-0.71.11.1
Pavlov. Cond. latency score0.20.31.0-0.00.1-0.2-0.3-0.30.40.3-0.3-0.5-0.60.6-0.7-0.81.00.9
Pavlov. Cond. lever contacts0.40.61.80.1-0.20.10.10.10.2-0.20.0-0.5-1.31.3-1.3-1.30.71.1
Pavlov. Cond. magazine entry number0.10.10.20.3-0.40.20.50.5-0.4-0.40.30.4-0.20.2-0.2-0.3-0.2-0.4
Pavlov. Cond. intertrial magazine entries0.20.51.4-0.70.7-0.9-0.6-0.70.50.8-1.2-0.20.7-0.70.50.40.80.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.1-0.20.3-0.4-0.4-0.40.50.4-0.4-0.7-0.60.6-0.6-0.71.01.1
Pavlov. Cond. response bias0.40.62.0-0.50.5-0.4-0.6-0.60.80.5-0.6-1.0-0.70.7-0.6-0.71.01.4
Time in closed arm before self-admin0.10.10.60.20.00.4-0.1-0.1-0.00.3-0.20.20.4-0.20.20.30.4-0.7
Time in closed arm after self-admin0.00.10.3-0.10.10.1-0.2-0.20.00.10.00.00.3-0.20.20.6-0.2-0.3
Time in open arm before self-admin0.70.82.5-0.70.8-0.8-1.0-0.81.01.1-1.1-1.1-0.00.0-0.0-0.31.61.4
Time in open arm after self-admin0.30.31.5-0.10.2-0.2-0.4-0.20.50.5-0.5-0.5-0.30.3-0.4-0.41.21.2
Bone: periosteal estimation0.61.43.61.4-0.90.80.80.9-1.4-0.30.41.41.9-1.71.61.4-0.3-1.2
Bone: periosteal perimeter0.20.41.70.30.0-0.2-0.1-0.2-0.40.4-0.40.31.3-1.11.10.90.3-0.3
Bone: post-yield work0.81.33.9-0.60.9-0.9-0.8-0.60.31.0-0.7-0.12.0-2.01.91.9-0.4-0.7
Progressive ratio test 1 active lever presses0.20.30.7-0.40.6-0.6-0.8-0.50.80.8-0.3-0.60.5-0.60.50.70.5-0.3
Progressive ratio test 1 breakpoint0.20.30.7-0.40.5-0.6-0.8-0.50.70.8-0.3-0.60.5-0.60.60.70.5-0.3
Progressive ratio test 1 inactive lever presses0.10.21.1-0.2-0.00.40.20.3-0.0-0.50.60.0-0.30.0-0.10.1-1.0-1.1
Progressive ratio test 2 active lever presses0.20.30.8-0.70.7-0.5-0.7-0.60.90.5-0.5-0.8-0.40.4-0.50.10.40.3
Progressive ratio test 2 breakpoint0.30.40.8-0.70.6-0.5-0.7-0.60.90.5-0.5-0.9-0.60.6-0.6-0.10.50.5
Progressive ratio test 2 inactive lever presses0.41.22.4-1.21.3-0.9-1.5-1.41.31.6-1.1-1.10.8-0.70.70.80.70.1
Incentive Sensitization - Responses0.10.40.8-0.80.7-0.5-0.6-0.60.70.5-0.8-0.8-0.40.5-0.5-0.00.60.9
Incentive Sensitization - Breakpoint0.20.40.8-0.80.6-0.5-0.5-0.60.70.4-0.7-0.8-0.60.6-0.7-0.10.50.9
Sum of active levers in priming session hrs 5-60.50.41.2-0.40.6-1.0-0.8-0.70.70.9-0.8-0.50.4-0.50.3-0.11.10.3
Progressive ratio2.26.611.63.3-3.32.73.43.4-3.4-3.32.92.9-0.80.8-0.9-1.0-1.7-1.1
Food seeking constrained by brief footshock0.20.31.10.3-0.31.00.10.1-0.0-0.20.3-0.2-0.70.6-0.7-0.80.50.8
Seeking ratio, punishment vs. effort1.84.17.2-2.32.5-2.0-2.7-2.72.62.7-2.4-2.30.4-0.30.30.32.01.1
Retroperitoneal fat weight0.10.42.90.0-0.20.80.50.1-0.4-0.80.90.1-0.20.20.00.8-1.7-0.4
Reaction time number correct0.62.24.01.4-1.62.01.62.0-1.4-1.71.61.3-1.31.1-1.3-1.9-0.9-0.7
Reaction time mean minus median0.53.05.1-1.92.1-2.2-2.1-1.91.92.1-2.1-1.81.1-1.01.11.51.21.4
Reaction time mean minus median AUC0.74.47.2-2.42.5-2.7-2.7-2.32.52.7-2.3-2.31.1-1.11.11.41.41.7
Reaction time num false alarms0.10.20.7-0.10.2-0.3-0.1-0.1-0.00.3-0.60.40.8-0.80.70.50.50.1
Reaction time num false alarms AUC0.10.20.60.3-0.2-0.20.20.1-0.40.1-0.60.80.7-0.60.50.10.70.2
Reaction time trials correct on left0.62.24.01.4-1.62.01.62.0-1.4-1.71.61.3-1.31.1-1.3-1.9-0.9-0.7
Reaction time trials on left0.62.13.91.4-1.51.91.62.0-1.3-1.61.61.3-1.21.1-1.2-1.8-0.8-0.7
Reaction time mean1.94.26.3-2.12.3-2.3-2.3-2.21.92.3-1.9-1.92.1-2.12.22.50.40.6
Reaction time mean AUC1.64.05.7-2.12.3-2.2-2.3-2.21.92.2-1.8-1.92.0-2.02.12.40.40.8
Median of all reaction times1.92.95.4-1.71.9-1.7-1.9-1.81.51.8-1.3-1.52.0-2.02.12.3-0.10.2
Reaction time omissions1.52.43.9-1.71.7-1.7-1.6-1.41.31.5-1.5-1.11.9-1.91.92.00.20.6
Reaction time false alarm rate0.81.12.4-0.60.8-1.3-0.9-1.10.51.2-1.5-0.11.4-1.21.21.11.30.6
Reaction time premature initiation rate0.10.20.60.3-0.30.60.30.3-0.4-0.30.50.00.3-0.10.20.6-0.5-0.8
Reaction time premature initiations0.51.43.21.3-1.31.81.41.6-1.3-1.41.51.0-0.50.5-0.5-0.4-1.1-1.2
Std. dev. reaction times1.13.85.8-1.82.1-2.4-2.3-2.11.92.4-2.3-1.81.8-1.61.71.91.61.2
Reaction time trials completed0.62.13.91.4-1.51.91.62.0-1.3-1.61.61.3-1.21.1-1.2-1.8-0.8-0.7
Reaction time trials AUC0.62.03.71.3-1.51.81.51.9-1.3-1.61.61.3-1.21.0-1.1-1.7-1.0-0.8
Run reversals in cocaine runway, females0.10.20.50.1-0.20.20.20.3-0.0-0.40.60.2-0.70.6-0.6-0.2-0.4-0.1
Run reversals in cocaine runway, males0.80.81.4-1.01.1-1.2-1.1-1.10.91.0-1.1-0.80.8-0.70.80.90.70.1
Latency to leave start box in cocaine runway1.21.62.9-1.31.3-1.3-1.2-1.41.01.2-1.0-1.01.6-1.71.71.7-0.10.4
Latency to leave start box in cocaine runway, F1.21.52.9-1.31.3-1.4-1.3-1.51.11.2-1.0-0.91.3-1.51.41.70.10.4
Latency to leave start box in cocaine runway, M0.20.20.6-0.20.2-0.2-0.1-0.1-0.10.0-0.1-0.10.8-0.80.80.5-0.50.0
Std. dev. time between licks in bursts1.42.66.2-1.01.4-1.4-1.4-1.10.81.8-1.9-0.72.5-2.42.42.11.00.3
Total sessions with >9 infusions0.10.21.40.1-0.0-0.2-0.4-0.10.50.5-0.1-0.2-0.30.3-0.4-0.41.20.3
Short access day 1 total inactive lever presses0.61.22.6-0.91.1-0.6-1.5-1.31.21.6-1.0-0.61.3-1.41.40.70.9-0.0
Short access day 10 total inactive lever presses0.00.30.8-0.80.6-0.2-0.1-0.50.1-0.1-0.5-0.10.8-0.80.90.6-0.8-0.5
Short access day 1 total infusions0.40.71.8-0.60.8-0.7-1.2-1.01.21.4-0.8-1.00.4-0.40.30.21.30.6
Short access day 10 total infusions0.20.30.7-0.50.5-0.5-0.7-0.40.90.6-0.3-0.8-0.30.1-0.2-0.10.60.2
Short access total infusions0.30.51.1-0.50.6-0.7-1.1-0.71.11.1-0.5-0.80.0-0.1-0.00.11.00.5
Short access day 1 locomotion0.50.92.0-1.21.1-1.4-1.0-1.11.11.0-1.0-1.00.7-0.80.80.80.40.2
Short access day 10 total locomotion0.41.75.61.5-1.20.51.11.0-1.6-0.60.61.91.5-1.31.31.0-0.2-2.4
Short access total locomotion0.30.51.50.2-0.0-0.4-0.2-0.1-0.10.4-0.00.41.1-1.11.01.20.0-1.1
One hour access (0.3 mA shock)0.70.92.1-1.41.2-1.3-1.0-1.11.20.8-1.1-1.3-0.10.1-0.10.10.40.3
Compulsive drug intake1.42.15.1-1.51.4-1.8-0.7-1.30.50.7-1.3-0.52.1-2.12.22.2-1.0-0.5
One hour access (shock baseline)0.30.82.90.0-0.10.4-0.20.10.60.10.2-0.7-1.61.6-1.7-1.60.90.6
Social response proportion0.40.51.60.7-0.40.30.30.2-0.7-0.00.30.81.3-1.31.20.9-0.2-0.6
Social responses0.30.41.01.0-0.80.20.70.4-1.0-0.40.31.00.7-0.50.40.50.0-0.3
Social time1.52.35.9-1.21.2-1.8-0.8-1.40.51.0-1.50.22.4-2.32.42.3-0.10.0
Soleus weight1.64.715.5-0.41.0-1.6-1.2-1.30.11.7-1.20.53.9-3.83.83.4-0.1-1.6
Bone: stiffness0.71.32.41.0-1.21.31.41.4-1.3-1.51.41.3-0.0-0.10.10.4-1.6-1.2
Tibialis anterior weight0.20.81.80.7-1.00.81.20.9-0.9-1.31.10.8-0.80.8-0.7-0.6-0.8-0.1
Time to tail flick, vehicle, before self-admin0.30.31.7-0.2-0.1-0.80.70.1-0.5-0.90.20.6-0.10.1-0.10.2-1.3-0.9
Time to tail flick, vehicle, after self-admin0.20.40.9-0.60.7-0.4-0.8-0.70.70.9-0.8-0.60.6-0.40.50.20.70.5
Time to tail flick, test, before self-admin0.30.30.80.3-0.50.30.70.7-0.4-0.70.10.0-0.80.8-0.9-0.70.3-0.6
Time to tail flick, test, after self-admin1.41.53.4-1.51.3-1.0-1.2-1.11.61.0-1.5-1.8-0.50.3-0.3-0.91.41.7
Delta time to tail flick, vehicle, before/after SA1.21.22.6-1.01.1-0.1-1.5-0.91.61.4-1.0-1.6-0.30.3-0.2-0.61.51.6
Delta time to tail flick, test, before/after SA0.50.61.6-1.11.0-0.8-0.9-1.01.00.6-0.5-1.0-0.0-0.20.20.1-0.31.3
Tibia length0.92.66.21.4-1.01.01.01.1-1.7-0.60.52.02.5-2.42.32.0-0.8-2.0
Ambulatory time before self-admin0.10.31.0-0.40.3-1.0-0.1-0.20.10.1-0.1-0.10.7-0.80.80.9-0.70.2
Ambulatory time after self-admin0.50.72.01.2-1.10.61.10.9-1.3-0.80.61.40.4-0.40.20.2-0.2-0.8
Bone: tissue strength0.10.10.30.1-0.10.3-0.00.2-0.10.00.40.20.2-0.30.30.5-0.5-0.5
Total heroin consumption0.00.00.1-0.10.0-0.20.1-0.2-0.1-0.0-0.30.10.3-0.30.2-0.20.0-0.0
Bone: trabecular number0.71.33.7-1.91.5-1.3-1.1-0.81.70.6-0.8-1.6-1.20.9-0.8-0.3-0.11.0
Bone: trabecular spacing1.01.54.42.1-1.61.61.21.0-1.8-0.81.01.60.8-0.60.50.0-0.0-1.1
Bone: trabecular thickness0.40.51.8-1.31.0-0.5-0.6-0.41.00.1-0.3-1.1-0.60.3-0.30.1-0.70.7
Bone: trabecular tissue density0.20.32.50.5-0.30.3-0.10.60.10.4-0.40.1-0.20.4-0.5-0.81.60.6
Water consumed over 24 hours0.10.20.7-0.10.2-0.2-0.2-0.40.00.3-0.3-0.10.8-0.80.70.70.0-0.1
Number of responses in last shaping day0.60.82.80.40.1-0.5-0.6-0.40.01.1-0.70.41.7-1.51.40.91.3-0.3