Hub : Genes

Trmt61a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	isoform ratio	NM_001007706.1	0.1	0.08	5.5e-10	0.08	0.08	0.08	0.08	7.6e-10	2.1e-09	1.2e-09	1.4e-09
2	NAcc	isoform ratio	XM_008764938.3	0.1	0.08	1.3e-09	0.08	0.08	0.08	0.08	1.6e-09	4.0e-09	2.2e-09	2.7e-09
3	NAcc	gene expression	Trmt61a	0.04	0.03	3.1e-05	0.04	0.04	0.04	0.04	1.8e-05	1.1e-05	2.1e-05	2.6e-05
4	Brain	isoform ratio	NM_001007706.1	0.04	0.06	4.3e-03	0.01	0.01	0.01	0.01	1.7e-02	4.3e-02	1.9e-02	4.4e-02
5	Brain	isoform ratio	XM_008764938.3	0.05	0.07	3.3e-03	0.01	0.01	0.01	0.01	1.3e-02	3.1e-02	1.4e-02	3.3e-02
6	Liver	gene expression	Trmt61a	0.06	0.05	3.3e-06	0.04	0.04	0.04	0.04	2.4e-05	4.9e-05	2.4e-05	3.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.1	-0.4	0.4	0.2	-0.2	0.2	0.1
Area under the delay curve	0.4	0.4	1.7	-0.0	0.0	0.3	-0.5	0.5	-1.3
BMI with tail	2.8	9.1	13.8	-2.7	2.7	2.9	-3.0	3.0	-3.7
BMI without tail	0.8	1.6	5.1	-0.9	0.9	1.1	-0.9	0.9	-2.3
Body weight	0.1	0.5	0.7	0.8	-0.8	-0.6	0.4	-0.4	-0.9
Weight adjusted by age	0.0	0.0	0.2	-0.1	0.1	-0.1	0.1	-0.1	-0.4
Bone surface	0.1	0.1	0.2	-0.5	0.5	0.2	-0.1	0.1	-0.3
Bone volume	0.0	0.0	0.1	-0.3	0.3	0.2	-0.1	0.1	0.1
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.1	0.2
Number of licking bursts	0.1	0.1	0.2	0.3	-0.3	-0.3	0.5	-0.5	0.2
Context. condit. distance diff. score	2.3	2.7	4.0	1.8	-1.8	-1.5	1.4	-1.4	2.0
Locomotion velocity, session 1	0.2	0.2	0.3	0.3	-0.3	-0.5	0.5	-0.5	0.1
Locomotion distance, session 1	0.4	0.5	0.9	-1.0	1.0	0.6	-0.7	0.7	0.1
Locomotion velocity, session 2	0.1	0.1	0.3	0.1	-0.1	0.1	-0.4	0.4	0.6
Locomotion distance, session 2	0.3	0.4	0.5	-0.7	0.7	0.6	-0.6	0.6	-0.0
Locomotion velocity, session 3	0.2	0.3	0.4	-0.4	0.4	0.4	-0.6	0.6	0.7
Locomotion distance, session 3	0.1	0.1	0.5	-0.1	0.1	-0.2	0.3	-0.3	0.7
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.4	-0.4	-0.4	0.3	-0.3	0.7
Stereotopy head waving duration, day 3	0.2	0.3	0.4	0.6	-0.6	-0.5	0.4	-0.4	0.7
Locomotion velocity, session 7	0.4	0.4	0.6	-0.5	0.5	0.5	-0.8	0.8	0.5
Locomotion distance, session 7	0.7	0.9	1.1	-0.9	0.9	1.0	-1.1	1.1	-0.4
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	0.8	-0.8	-1.1	1.0	-1.0	0.8
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.4	-0.4	-0.6	0.5	-0.5	0.5
Locomotion velocity, session 8	0.4	0.5	1.1	0.9	-0.9	-0.4	0.3	-0.3	1.1
Locomotion distance, session 8	0.1	0.1	0.8	0.1	-0.1	0.1	-0.1	0.1	0.9
Degree of sensitization distance	0.2	0.2	0.3	-0.3	0.3	0.4	-0.5	0.5	-0.4
Degree of sensitization stereotypy	0.1	0.1	0.2	0.0	-0.0	-0.5	0.5	-0.5	0.3
Conditioned locomotion	1.4	1.7	2.3	1.5	-1.5	-1.2	1.0	-1.0	1.4
Cocaine response after cond. corrected	0.5	0.6	0.7	-0.8	0.8	0.7	-0.6	0.6	-0.9
Cocaine response after cond. not corrected	1.7	1.9	2.0	-1.4	1.4	1.4	-1.3	1.3	-1.3
Cocaine response before conditioning	2.1	2.6	3.2	-1.6	1.6	1.7	-1.8	1.8	-1.2
Saline control response	0.1	0.1	0.2	-0.3	0.3	0.5	-0.5	0.5	-0.2
Bone: connectivity density	0.0	0.1	0.2	0.2	-0.2	-0.2	0.2	-0.2	0.4
Bone: cortical apparent density	8.5	11.2	11.5	3.4	-3.4	-3.4	3.3	-3.3	3.3
Bone: cortical area	1.1	1.7	2.5	1.0	-1.0	-1.3	1.6	-1.6	1.1
Bone: cortical porosity	0.1	0.1	0.6	-0.0	0.0	-0.0	-0.1	0.1	0.8
Bone: cortical porosity	0.2	0.3	0.3	-0.6	0.6	0.5	-0.5	0.5	0.3
Bone: cortical thickness	1.2	2.1	3.8	0.9	-0.9	-1.4	1.6	-1.6	1.9
Bone: cortical thickness	1.2	1.4	2.6	0.9	-0.9	-1.0	1.3	-1.3	1.6
Bone: cortical tissue density	8.6	11.3	11.6	3.4	-3.4	-3.4	3.3	-3.3	3.3
Condit. Reinf. active minus inactive responses	0.5	0.6	0.6	-0.8	0.8	0.8	-0.7	0.7	-0.7
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.3	-1.8	1.8	1.6	-1.6	1.6	-1.5
Condit. Reinf. active responses	0.1	0.2	0.3	-0.3	0.3	0.4	-0.5	0.5	-0.2
Condit. Reinf. inactive responses	1.9	2.2	2.8	1.5	-1.5	-1.5	1.4	-1.4	1.7
Incentive salience index mean	0.5	0.7	0.9	-0.9	0.9	0.7	-0.8	0.8	-0.8
Condit. Reinf. lever presses	0.2	0.2	0.3	-0.5	0.5	0.4	-0.6	0.6	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	0.9	-0.9	-0.6	0.4	-0.4	0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	0.9	-0.9	-0.6	0.5	-0.5	0.5
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3	0.3	-0.0
Condit. Reinf. inactive responses	0.5	0.6	0.8	-0.7	0.7	0.9	-0.9	0.9	-0.7
Condit. Reinf. lever presses	1.4	2.0	2.5	-1.2	1.2	1.5	-1.6	1.6	-1.2
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	0.2	-0.2	0.1	-0.3	0.3	-0.1
Conditioned reinforcement - actives	2.1	2.1	2.4	1.5	-1.5	-1.4	1.4	-1.4	1.3
Conditioned reinforcement - inactives	0.3	0.4	0.5	0.6	-0.6	-0.6	0.7	-0.7	0.5
Conditioned locomotion	0.6	0.7	0.9	-1.0	1.0	0.9	-0.9	0.9	-0.2
Patch foraging indifference point 0 sec	3.4	5.4	7.8	2.8	-2.8	-2.3	2.0	-2.0	1.9
Patch foraging indifference point AUC	2.3	2.7	3.1	1.7	-1.7	-1.8	1.6	-1.6	1.4
Delay disc. indifference point, 0s delay	0.1	0.2	0.4	0.6	-0.6	-0.3	0.1	-0.1	-0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.8	0.3	-0.3	0.2	-0.3	0.3	-0.9
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.1	0.1	0.2	-0.2	0.2	-0.3
Delay disc. indifference point, 24s delay	0.4	0.3	1.7	-0.4	0.4	0.2	-0.0	0.0	-1.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.6	-0.6	-0.3	0.1	-0.1	-0.5
Delay disc. indifference point, 8s delay	0.7	0.8	3.1	-0.2	0.2	0.5	-0.8	0.8	-1.8
Indifference point function ln k	0.5	0.6	0.7	0.9	-0.9	-0.8	0.8	-0.8	0.6
Indifference point function log k	0.5	0.6	0.7	0.9	-0.9	-0.8	0.8	-0.8	0.6
Patch foraging total patch changes 0 sec	3.7	6.0	8.8	3.0	-3.0	-2.4	2.1	-2.1	2.0
Patch foraging total patch changes 12 sec	3.5	4.5	5.8	2.4	-2.4	-2.2	1.8	-1.8	2.0
Patch foraging total patch changes 18 sec	1.7	2.1	4.3	1.6	-1.6	-1.3	0.8	-0.8	2.1
Patch foraging total patch changes 24 sec	0.2	0.2	0.5	0.7	-0.7	-0.4	0.2	-0.2	0.0
Patch foraging total patch changes 6 sec	2.2	3.3	5.8	2.4	-2.4	-1.7	1.5	-1.5	1.0
Patch foraging time to switch 0 sec	11.0	16.9	17.6	-4.2	4.2	4.2	-4.1	4.1	-3.9
Patch foraging water rate 0 sec	18.6	29.9	34.0	5.8	-5.8	-5.6	5.4	-5.4	4.7
Patch foraging water rate 12 sec	9.3	14.2	17.6	4.2	-4.2	-3.8	3.8	-3.8	2.4
Patch foraging water rate 18 sec	4.9	6.6	7.9	2.6	-2.6	-2.7	2.8	-2.8	1.7
Patch foraging water rate 24 sec	4.3	5.9	6.7	2.6	-2.6	-2.4	2.6	-2.6	1.8
Patch foraging water rate 6 sec	5.2	7.5	8.4	2.9	-2.9	-2.6	2.6	-2.6	2.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.1	-0.1	-0.5	0.4	-0.4	0.2
Distance traveled before self-admin	0.1	0.1	0.6	-0.1	0.1	0.1	-0.1	0.1	-0.8
Distance traveled after self-admin	0.6	0.7	1.1	0.8	-0.8	-0.7	0.8	-0.8	1.1
Extensor digitorum longus weight	5.7	22.4	23.7	4.9	-4.9	-4.8	4.8	-4.8	4.2
Bone: elastic displacement	0.8	0.9	1.8	0.6	-0.6	-0.9	1.0	-1.0	1.4
Bone: elastic work	0.2	0.3	0.6	0.1	-0.1	-0.4	0.6	-0.6	0.8
Bone: endosteal estimation	0.4	0.8	3.1	-0.4	0.4	0.7	-0.7	0.7	-1.8
Bone: endosteal perimeter	0.2	0.3	1.9	0.1	-0.1	0.0	0.1	-0.1	-1.4
Epididymis fat weight	4.6	10.7	11.8	-3.2	3.2	3.3	-3.3	3.3	-3.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.1	0.2	-0.1	0.1	-0.2
Delta time in open arm before/after self-admin	0.4	0.4	0.4	0.6	-0.6	-0.7	0.7	-0.7	-0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.2	-0.2	-0.2	0.2	-0.2	0.6
Delay discount exponential model param	0.3	0.3	1.4	0.0	-0.0	-0.2	0.4	-0.4	1.2
Extinction: sum of active levers before priming	0.2	0.2	1.0	-0.1	0.1	0.0	0.1	-0.1	1.0
Active lever presses in extinction session 6	1.4	1.4	1.5	1.2	-1.2	-1.1	1.2	-1.2	1.0
Bone: final force	0.3	0.5	0.8	0.5	-0.5	-0.7	0.9	-0.9	0.6
Bone: final moment	0.4	0.6	1.0	0.6	-0.6	-0.8	1.0	-1.0	0.7
Food consumed during 24 hour testing period	0.1	0.2	0.2	0.4	-0.4	-0.4	0.5	-0.5	0.2
Glucose	0.8	1.2	1.3	1.1	-1.1	-1.2	1.1	-1.1	1.1
Heart weight	0.0	0.0	0.1	-0.3	0.3	0.1	-0.2	0.2	0.3
Delay discount hyperbolic model param	0.3	0.3	1.4	0.1	-0.1	-0.3	0.4	-0.4	1.2
Intermittent access intake day 1-15 change	1.1	1.1	1.3	-1.1	1.1	1.1	-1.1	1.1	-0.2
Intermittent access intake escalation	1.2	1.2	1.5	-1.2	1.2	1.2	-1.2	1.2	0.0
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.4	0.4	0.3	-0.1	0.1	0.6
Intermitt. access day 1 inactive lever presses	2.7	2.9	3.1	1.7	-1.7	-1.7	1.6	-1.6	1.6
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.5	1.2	-1.2	-1.0	1.1	-1.1	0.6
Intermitt. access escalation Index	0.3	0.2	0.4	0.6	-0.6	-0.5	0.4	-0.4	-0.4
Intermittent access day 1 total infusions	0.6	0.7	1.7	-0.6	0.6	0.7	-0.8	0.8	-1.3
Intermittent access day 15 total infusions	1.8	2.0	2.3	-1.4	1.4	1.5	-1.5	1.5	-1.1
Intermittent access terminal intake (last 3 days)	2.2	2.4	2.6	-1.5	1.5	1.5	-1.6	1.6	-1.6
Intermittent access total infusions	0.8	0.9	1.2	-0.8	0.8	0.9	-1.0	1.0	-1.1
Intermittent access day 1 locomotion	1.2	1.3	2.0	-1.0	1.0	1.0	-1.1	1.1	-1.4
Intermittent access day 15 total locomotion	0.3	0.3	0.4	-0.6	0.6	0.6	-0.6	0.6	-0.3
Intermittent access total locomotion	0.4	0.5	0.7	-0.7	0.7	0.7	-0.8	0.8	-0.4
Intermittent access standard deviation	3.3	3.5	4.0	-1.9	1.9	2.0	-2.0	2.0	-1.3
Left kidney weight	0.6	1.7	2.5	1.6	-1.6	-1.3	1.2	-1.2	0.7
Right kidney weight	0.3	0.7	1.1	1.0	-1.0	-0.8	0.8	-0.8	0.4
Cocaine induced anxiety	2.7	3.2	3.5	1.9	-1.9	-1.9	1.9	-1.9	1.3
Post-drug Anxiety	2.3	2.6	2.9	1.7	-1.7	-1.7	1.7	-1.7	1.2
Baseline Anxiety	1.4	1.5	1.7	-1.3	1.3	1.3	-1.3	1.3	-0.9
Tail length	3.0	9.1	10.1	3.2	-3.2	-3.1	3.2	-3.2	2.2
Length with tail	3.9	14.4	15.4	3.9	-3.9	-3.9	3.8	-3.8	3.4
Length without tail	1.7	3.7	5.9	1.9	-1.9	-2.0	1.6	-1.6	2.4
Times rat made contact with spout	0.3	0.3	0.5	0.7	-0.7	-0.6	0.4	-0.4	0.5
Lifetime Intake	0.4	0.5	0.6	-0.5	0.5	0.7	-0.8	0.8	-0.8
Liver weight, left	3.4	5.4	7.1	2.3	-2.3	-2.3	2.7	-2.7	1.6
Liver weight, right	0.1	0.1	0.5	-0.2	0.2	-0.1	0.1	-0.1	-0.7
Locomotor activity	0.1	0.2	0.6	0.4	-0.4	-0.3	0.3	-0.3	0.8
Locomotor testing distance	0.5	0.9	2.5	0.9	-0.9	-0.7	0.6	-0.6	1.6
Locomotor testing rearing	1.1	1.8	3.0	-1.1	1.1	1.4	-1.7	1.7	-0.0
Locomotion in novel chamber	5.1	6.2	6.9	2.6	-2.6	-2.6	2.6	-2.6	1.8
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.2	0.2	0.3	-0.0	0.0	-0.5
Fecal boli incidents, locomotor time 1	1.7	1.9	2.2	-1.4	1.4	1.4	-1.2	1.2	-1.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	0.8	-0.8	-0.4	0.2	-0.2	0.2
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.3	-0.5	0.5	0.7	-0.7	0.7	-1.1
Bouts of movement, locomotor time 1	0.9	0.9	1.2	-1.1	1.1	1.1	-1.0	1.0	-0.3
Total resting periods, locomotor time 1	0.9	0.9	1.3	-1.0	1.0	1.1	-1.0	1.0	-0.5
Rest time, locomotor task time 1	0.2	0.3	0.5	0.5	-0.5	-0.5	0.7	-0.7	-0.2
Distance moved, locomotor task time 1	0.5	0.5	0.7	-0.7	0.7	0.6	-0.7	0.7	0.9
Vertical activity count, locomotor time 1	0.8	0.8	2.2	0.8	-0.8	-0.8	0.7	-0.7	1.5
Time >=10cm from walls, locomotor time 2	0.5	0.6	0.7	0.8	-0.8	-0.8	0.7	-0.7	0.6
Bouts of movement, locomotor time 2	2.7	2.9	3.8	1.6	-1.6	-1.5	1.8	-1.8	2.0
Total resting periods, locomotor time 2	2.0	2.1	2.4	1.5	-1.5	-1.3	1.5	-1.5	1.5
Rest time, locomotor task time 2	0.5	0.5	1.1	0.6	-0.6	-0.6	1.1	-1.1	-0.1
Distance moved, locomotor task time 2	0.3	0.4	0.6	-0.5	0.5	0.5	-0.8	0.8	0.8
Vertical activity count, locomotor time 2	0.6	0.7	2.0	0.6	-0.6	-0.8	0.6	-0.6	1.4
Light reinforcement 1	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3	0.3	0.0
Light reinforcement 2	1.1	1.4	2.0	-1.1	1.1	1.4	-1.1	1.1	-1.2
Bone: marrow area	0.3	0.7	2.8	-0.3	0.3	0.6	-0.6	0.6	-1.7
Bone: maximum diameter	0.1	0.2	0.3	0.1	-0.1	-0.3	0.5	-0.5	-0.5
Bone: maximum force	0.3	0.6	0.8	0.6	-0.6	-0.8	0.9	-0.9	0.6
Bone: maximum moment	0.3	0.5	0.9	0.5	-0.5	-0.7	0.9	-0.9	0.5
Mean time between licks in bursts	0.7	0.9	1.4	-0.7	0.7	1.2	-1.2	1.2	-0.7
Mean num. licks in bursts	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.2	0.2	0.2
Cd content in liver	0.6	0.6	0.9	1.0	-1.0	-0.7	0.9	-0.9	0.2
Co content in liver	0.9	1.1	1.6	1.1	-1.1	-1.0	0.9	-0.9	1.3
Cu content in liver	1.1	1.3	2.3	-1.0	1.0	1.1	-1.0	1.0	-1.5
Fe content in liver	0.2	0.3	0.6	-0.6	0.6	0.3	-0.3	0.3	-0.8
K content in liver	0.1	0.1	0.6	0.3	-0.3	-0.3	0.2	-0.2	0.8
Mg content in liver	0.2	0.2	0.7	0.5	-0.5	-0.2	-0.0	0.0	0.8
Mn content in liver	0.3	0.4	2.0	0.2	-0.2	-0.1	-0.1	0.1	1.4
Na content in liver	0.1	0.1	0.3	-0.4	0.4	0.1	-0.0	0.0	0.5
Rb content in liver	0.6	0.7	1.2	1.1	-1.1	-0.9	0.6	-0.6	0.7
Se content in liver	0.4	0.5	2.7	-0.5	0.5	0.2	0.1	-0.1	-1.6
Sr content in liver	0.4	0.3	0.5	0.6	-0.6	-0.6	0.7	-0.7	-0.5
Zn content in liver	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	-0.5	0.2
Bone: minimum diameter	0.6	1.1	1.6	1.3	-1.3	-1.1	1.1	-1.1	0.3
Time in familiar zone, hab. session 1	0.6	0.6	1.1	-0.5	0.5	0.7	-1.0	1.0	0.3
Time in novel zone, hab. session 1	0.5	0.5	2.5	-0.4	0.4	0.2	0.1	-0.1	-1.6
Total zone transitions, hab. session 1	0.5	0.7	0.9	-0.9	0.9	0.9	-0.8	0.8	-0.3
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.4	-0.4	-0.2	0.3	-0.3	0.7
Locomotion velocity, hab. session 1	0.7	0.9	1.6	1.0	-1.0	-0.8	0.8	-0.8	1.3
Time in familiar zone, hab. session 2	0.6	0.7	1.2	-0.7	0.7	0.8	-1.1	1.1	-0.0
Time in novel zone, hab. session 2	0.1	0.1	0.6	-0.0	0.0	0.1	0.2	-0.2	-0.8
Total zone transitions, hab. session 2	0.5	0.6	0.9	-0.9	0.9	0.9	-0.8	0.8	-0.1
Total locomotion distance, hab. session 2	0.8	1.0	2.2	0.8	-0.8	-0.8	1.0	-1.0	1.5
Locomotion velocity, hab. session 2	1.0	1.4	2.8	1.0	-1.0	-0.9	1.1	-1.1	1.7
Novel to familiar place preference ratio	0.3	0.3	0.5	-0.7	0.7	0.6	-0.4	0.4	-0.6
Novelty place preference	0.2	0.2	0.3	-0.5	0.5	0.4	-0.3	0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	-0.5	0.5	0.4	-0.2	0.2	-0.4
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	0.3	0.4	-0.2	0.2	0.2
Total locomotion distance, NPP test	0.1	0.2	0.5	0.2	-0.2	-0.2	0.5	-0.5	0.7
Locomotion velocity, NPP test	0.2	0.3	0.7	0.3	-0.3	-0.3	0.6	-0.6	0.8
Intraocular pressure	0.1	0.2	0.3	-0.5	0.5	0.3	-0.3	0.3	-0.6
Delta distance traveled before/after self-admin	0.3	0.3	1.7	0.2	-0.2	-0.1	0.2	-0.2	1.3
Delta ambulatory time before/after self-admin	0.9	1.0	2.9	0.8	-0.8	-0.7	0.8	-0.8	1.7
Parametrial fat weight	0.0	0.1	0.5	-0.2	0.2	0.0	0.1	-0.1	-0.7
Pavlov. Cond. lever latency	0.7	0.9	1.3	1.1	-1.1	-0.9	0.9	-0.9	0.7
Pavlov. Cond. magazine entry latency	0.5	0.7	0.9	-0.9	0.9	0.8	-0.9	0.9	-0.3
Pavlov. Cond. change in total contacts	0.4	0.4	0.5	-0.7	0.7	0.6	-0.7	0.7	0.0
Pavlov. Cond. index score	1.0	1.3	1.9	-1.4	1.4	1.1	-1.1	1.1	-0.8
Pavlov. Cond. latency score	0.7	0.9	1.3	-1.1	1.1	0.9	-0.8	0.8	-0.7
Pavlov. Cond. lever contacts	1.0	1.2	1.6	-1.3	1.3	1.0	-1.0	1.0	-0.8
Pavlov. Cond. magazine entry number	1.0	1.2	1.4	1.1	-1.1	-1.2	1.2	-1.2	0.8
Pavlov. Cond. intertrial magazine entries	5.3	6.4	6.7	2.6	-2.6	-2.6	2.5	-2.5	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.5	-1.2	1.2	0.9	-0.8	0.8	-0.8
Pavlov. Cond. response bias	1.2	1.4	1.7	-1.3	1.3	1.2	-1.2	1.2	-0.7
Pavlov. Cond. lever latency	1.8	2.4	3.1	1.5	-1.5	-1.8	1.7	-1.7	1.1
Pavlov. Cond. magazine entry latency	5.4	6.2	7.5	-2.5	2.5	2.5	-2.4	2.4	-2.7
Pavlov. Cond. change in total contacts	3.9	5.4	6.5	-2.2	2.2	2.4	-2.5	2.5	-2.0
Pavlov. Cond. index score	5.0	6.4	7.1	-2.4	2.4	2.6	-2.7	2.7	-2.4
Pavlov. Cond. latency score	4.9	6.1	6.7	-2.4	2.4	2.6	-2.6	2.6	-2.3
Pavlov. Cond. lever contacts	2.5	3.4	4.3	-1.7	1.7	2.1	-2.0	2.0	-1.5
Pavlov. Cond. magazine entry number	4.2	5.1	5.8	2.1	-2.1	-2.3	2.4	-2.4	2.2
Pavlov. Cond. intertrial magazine entries	5.3	7.0	7.8	2.8	-2.8	-2.6	2.4	-2.4	2.8
Pavlov. Cond. lever-magazine prob. diff.	5.5	7.0	8.0	-2.4	2.4	2.8	-2.8	2.8	-2.5
Pavlov. Cond. response bias	3.6	4.9	5.9	-2.0	2.0	2.4	-2.4	2.4	-1.9
Time in closed arm before self-admin	3.3	3.7	4.8	-1.9	1.9	1.9	-1.8	1.8	-2.2
Time in closed arm after self-admin	1.9	2.0	3.9	-1.2	1.2	1.3	-1.3	1.3	-2.0
Time in open arm before self-admin	4.9	5.3	5.9	2.4	-2.4	-2.4	2.2	-2.2	2.2
Time in open arm after self-admin	2.7	3.0	3.5	1.9	-1.9	-1.9	1.8	-1.8	1.1
Bone: periosteal estimation	0.1	0.3	0.4	0.5	-0.5	-0.5	0.6	-0.6	-0.5
Bone: periosteal perimeter	0.1	0.2	0.4	0.4	-0.4	-0.3	0.6	-0.6	-0.6
Bone: post-yield work	1.2	1.6	1.8	1.3	-1.3	-1.3	1.3	-1.3	1.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.0	-0.0	0.2	-0.3	0.3	-0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.2	0.2	0.3	-0.5	0.5	-0.5
Progressive ratio test 1 inactive lever presses	3.0	3.2	4.1	1.8	-1.8	-1.8	1.7	-1.7	2.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.3	1.1	-1.1	-1.0	0.9	-0.9	0.9
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	0.1	0.1	0.0	-0.0	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.3	0.3	0.4	-0.4	0.4	0.5
Progressive ratio	0.5	0.5	0.6	0.7	-0.7	-0.7	0.7	-0.7	0.7
Food seeking constrained by brief footshock	1.7	2.1	2.8	1.3	-1.3	-1.6	1.7	-1.7	1.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.2	-0.2	-0.3	0.4	-0.4	0.3
Retroperitoneal fat weight	0.3	1.1	2.9	-1.0	1.0	0.8	-0.7	0.7	-1.7
Reaction time number correct	2.5	3.6	4.2	2.0	-2.0	-2.1	1.7	-1.7	1.8
Reaction time mean minus median	0.4	0.6	2.1	-0.7	0.7	0.4	-0.3	0.3	-1.5
Reaction time mean minus median AUC	0.3	0.4	1.7	-0.5	0.5	0.4	-0.2	0.2	-1.3
Reaction time num false alarms	1.0	1.4	1.9	1.4	-1.4	-1.1	1.0	-1.0	1.2
Reaction time num false alarms AUC	1.5	2.1	2.5	1.6	-1.6	-1.4	1.4	-1.4	1.4
Reaction time trials correct on left	2.5	3.6	4.2	2.0	-2.0	-2.1	1.7	-1.7	1.8
Reaction time trials on left	2.5	3.5	4.2	2.0	-2.0	-2.0	1.7	-1.7	1.7
Reaction time mean	0.9	1.2	1.4	-1.2	1.2	1.2	-1.0	1.0	-0.9
Reaction time mean AUC	0.6	0.7	0.9	-0.9	0.9	0.9	-0.8	0.8	-0.8
Median of all reaction times	0.4	0.6	0.9	-0.8	0.8	0.9	-0.9	0.9	-0.2
Reaction time omissions	0.6	0.9	1.3	0.7	-0.7	-1.1	1.2	-1.2	0.6
Reaction time false alarm rate	0.2	0.2	0.3	0.6	-0.6	-0.3	0.5	-0.5	0.4
Reaction time premature initiation rate	0.9	1.2	1.7	1.3	-1.3	-1.0	0.7	-0.7	1.3
Reaction time premature initiations	2.4	3.4	4.4	2.1	-2.1	-1.8	1.4	-1.4	2.1
Std. dev. reaction times	0.6	0.9	2.5	-1.0	1.0	0.7	-0.5	0.5	-1.6
Reaction time trials completed	2.5	3.5	4.2	2.0	-2.0	-2.0	1.7	-1.7	1.7
Reaction time trials AUC	2.6	3.8	4.5	2.1	-2.1	-2.1	1.8	-1.8	1.8
Run reversals in cocaine runway, females	1.0	1.0	1.1	-0.9	0.9	1.1	-1.0	1.0	-1.0
Run reversals in cocaine runway, males	0.9	0.9	1.1	0.9	-0.9	-1.0	1.0	-1.0	1.1
Latency to leave start box in cocaine runway	0.1	0.2	0.4	0.1	-0.1	0.4	-0.6	0.6	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.1	-0.1	0.4	-0.7	0.7	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.1	0.1	0.3	-0.3	0.3	-0.3
Std. dev. time between licks in bursts	0.5	0.6	0.8	-0.7	0.7	0.9	-0.8	0.8	-0.5
Total sessions with >9 infusions	0.2	0.2	0.5	-0.1	0.1	0.2	-0.7	0.7	0.6
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3	0.3	0.2
Short access day 10 total inactive lever presses	0.4	0.5	0.6	0.7	-0.7	-0.6	0.8	-0.8	0.6
Short access day 1 total infusions	0.2	0.2	0.3	0.6	-0.6	-0.5	0.3	-0.3	0.2
Short access day 10 total infusions	0.7	0.8	2.1	-0.6	0.6	0.7	-0.8	0.8	-1.4
Short access total infusions	0.3	0.4	0.6	-0.4	0.4	0.5	-0.7	0.7	-0.8
Short access day 1 locomotion	0.8	0.9	1.2	-0.8	0.8	0.9	-1.1	1.1	-1.0
Short access day 10 total locomotion	0.6	0.7	0.9	-0.8	0.8	0.8	-1.0	1.0	-0.7
Short access total locomotion	0.1	0.1	0.2	-0.3	0.3	0.3	-0.5	0.5	-0.3
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3	-0.3	0.3
Compulsive drug intake	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	-0.0	-0.3
One hour access (shock baseline)	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	0.2	0.2
Social response proportion	0.3	0.3	0.6	0.8	-0.8	-0.5	0.3	-0.3	0.4
Social responses	0.0	0.0	0.1	0.1	-0.1	0.2	-0.3	0.3	-0.1
Social time	0.8	1.0	1.2	1.1	-1.1	-1.0	1.1	-1.1	0.8
Soleus weight	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	0.2	0.3
Bone: stiffness	1.7	2.6	3.4	1.6	-1.6	-1.7	1.9	-1.9	1.1
Tibialis anterior weight	0.3	1.0	1.1	1.1	-1.1	-1.0	1.0	-1.0	0.8
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.9	0.6	-0.6	-0.8	0.9	-0.9	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.4	0.4	0.4	-0.5	0.5	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.4	-0.4	-0.2	0.1	-0.1	0.5
Time to tail flick, test, after self-admin	1.4	1.5	1.8	1.1	-1.1	-1.3	1.3	-1.3	1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.2	0.2	0.3	-0.6	0.6	-0.1
Delta time to tail flick, test, before/after SA	1.0	0.9	1.4	0.7	-0.7	-1.0	1.2	-1.2	0.7
Tibia length	0.4	1.2	1.6	1.1	-1.1	-1.1	1.3	-1.3	0.7
Ambulatory time before self-admin	0.2	0.3	1.2	-0.3	0.3	0.2	-0.2	0.2	-1.1
Ambulatory time after self-admin	0.0	0.0	0.1	0.0	-0.0	0.1	0.0	-0.0	0.3
Bone: tissue strength	0.1	0.1	0.3	0.1	-0.1	-0.4	0.6	-0.6	-0.2
Total heroin consumption	1.1	1.3	1.4	1.1	-1.1	-1.2	1.2	-1.2	1.2
Bone: trabecular number	0.0	0.1	0.3	0.2	-0.2	-0.2	0.1	-0.1	0.5
Bone: trabecular spacing	0.0	0.0	0.2	-0.1	0.1	0.2	0.1	-0.1	-0.4
Bone: trabecular thickness	0.1	0.2	0.4	0.4	-0.4	-0.4	0.3	-0.3	0.6
Bone: trabecular tissue density	0.2	0.3	0.7	0.4	-0.4	-0.5	0.3	-0.3	0.8
Water consumed over 24 hours	3.2	3.8	4.7	2.2	-2.2	-2.0	1.8	-1.8	1.7
Number of responses in last shaping day	0.3	0.4	0.5	-0.7	0.7	0.7	-0.5	0.5	-0.5