Hub : Genes

Tppp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Tppp3 0.42 0.35 5.1e-05 0.15 0.13 0.17 0.14 1.6e-04 4.7e-04 6.5e-05 2.5e-04
2 pVTA gene expression Tppp3 0.21 0.13 9.1e-15 0.18 0.17 0.17 0.19 1.5e-14 9.6e-14 5.6e-14 7.2e-15
3 IC gene expression Tppp3 0.16 0.11 2.8e-06 0.14 0.13 0.12 0.14 1.4e-06 5.0e-06 8.3e-06 1.9e-06
4 NAcc gene expression Tppp3 0.13 0.07 2.9e-15 0.09 0.08 0.09 0.09 8.4e-13 1.3e-11 1.6e-13 4.2e-13
5 IL gene expression Tppp3 0.53 0.17 6.3e-12 0.4 0.3 0.34 0.33 1.6e-10 7.8e-08 6.0e-09 1.2e-08
6 BLA mRNA stability Tppp3 0.1 0.08 1.5e-05 0.11 0.08 0.07 0.09 2.0e-06 5.5e-05 1.5e-04 1.4e-05
7 BLA gene expression Tppp3 0.3 0.14 0.0e+00 0.31 0.35 0.35 0.34 4.0e-17 1.3e-19 1.8e-19 4.6e-19
8 Brain mRNA stability Tppp3 0.07 0.06 2.9e-06 0.07 0.06 0.06 0.06 5.9e-07 6.3e-06 7.1e-06 7.1e-06
9 LHb mRNA stability Tppp3 0.21 0.19 2.2e-03 0.14 0.1 0.04 0.13 2.7e-04 2.0e-03 3.7e-02 6.4e-04
10 PL gene expression Tppp3 0.25 0.12 0.0e+00 0.22 0.22 0.2 0.21 4.5e-23 2.3e-23 5.6e-22 1.0e-22
11 PL mRNA stability Tppp3 0.05 0.04 9.7e-07 0.04 0.05 0.03 0.04 7.2e-05 1.5e-06 1.3e-04 4.8e-05
12 IC mRNA stability Tppp3 0.06 0.05 6.7e-03 0.01 0.02 -0 0 1.7e-01 5.3e-02 5.4e-01 2.8e-01
13 Brain gene expression Tppp3 0.03 0.02 4.7e-03 0 0 -0 -0 3.4e-01 2.7e-01 6.5e-01 5.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.8-0.9-0.2-0.40.4-0.3-0.3-0.4-0.2-0.2-0.3-0.3-0.3-0.3
Area under the delay curve0.40.56.22.5-0.10.6-0.10.20.20.0-0.1-0.10.10.0-0.00.0
BMI with tail0.10.30.9-0.7-0.5-0.20.5-0.6-0.5-0.4-0.9-0.8-0.1-0.3-0.3-0.3
BMI without tail0.00.10.50.70.20.2-0.0-0.00.10.0-0.4-0.30.10.0-0.00.0
Body weight0.31.42.9-1.7-0.9-1.11.2-1.0-0.9-1.2-1.3-1.3-1.2-1.2-1.2-1.2
Weight adjusted by age0.10.11.2-1.1-0.1-0.20.00.00.2-0.00.1-0.0-0.1-0.1-0.1-0.1
Bone surface1.12.02.8-1.2-1.2-1.61.6-1.3-1.3-1.6-1.0-1.1-1.7-1.6-1.5-1.6
Bone volume0.91.72.6-1.6-1.0-1.51.4-1.1-1.1-1.4-0.8-0.9-1.5-1.4-1.4-1.4
Breakpoint value in progressive ratio session1.82.24.0-0.21.42.0-1.51.31.21.51.51.51.51.61.61.6
Number of licking bursts0.50.91.1-0.6-1.1-0.91.0-0.9-0.9-1.0-0.9-0.9-1.0-1.0-1.0-1.0
Context. condit. distance diff. score0.20.21.01.00.40.3-0.30.60.50.20.80.7-0.10.10.20.2
Locomotion velocity, session 10.10.10.40.6-0.20.00.2-0.3-0.3-0.2-0.3-0.3-0.0-0.2-0.2-0.2
Locomotion distance, session 10.10.20.40.60.40.3-0.40.40.40.40.50.50.30.30.30.3
Locomotion velocity, session 21.01.22.31.51.10.8-1.01.21.21.01.31.30.70.80.90.8
Locomotion distance, session 20.20.20.40.50.60.2-0.40.60.60.40.60.60.30.30.30.3
Locomotion velocity, session 30.20.30.60.60.40.7-0.50.40.40.50.40.30.70.60.60.6
Locomotion distance, session 30.10.10.20.50.20.4-0.20.40.30.20.50.4-0.10.10.10.1
Stereotopy head waving bouts, day 30.10.20.30.3-0.5-0.50.3-0.5-0.5-0.3-0.5-0.5-0.2-0.3-0.3-0.3
Stereotopy head waving duration, day 30.50.60.9-0.7-0.9-1.00.8-0.9-0.9-0.8-0.9-0.8-0.6-0.7-0.7-0.8
Locomotion velocity, session 70.10.10.30.10.30.2-0.10.30.30.10.50.50.10.10.10.1
Locomotion distance, session 70.10.10.30.50.20.1-0.20.30.30.20.60.50.00.20.20.2
Stereotopy head waving bouts, day 70.20.30.4-0.6-0.7-0.30.5-0.6-0.6-0.5-0.6-0.6-0.3-0.4-0.4-0.4
Stereotopy head waving duration, day 70.70.91.4-1.0-1.1-0.70.9-1.1-1.1-0.8-1.2-1.1-0.6-0.7-0.7-0.7
Locomotion velocity, session 80.10.10.8-0.90.10.3-0.10.20.10.10.20.10.30.20.20.2
Locomotion distance, session 80.60.81.81.31.00.8-0.81.11.00.71.21.10.50.70.70.7
Degree of sensitization distance0.00.00.10.2-0.1-0.30.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1
Degree of sensitization stereotypy0.40.40.7-0.8-0.8-0.50.7-0.7-0.7-0.6-0.8-0.8-0.5-0.5-0.5-0.5
Conditioned locomotion1.92.13.4-1.5-1.4-1.51.6-1.3-1.3-1.5-1.0-1.0-1.8-1.6-1.6-1.6
Cocaine response after cond. corrected0.70.82.1-1.1-0.7-0.70.9-1.1-1.0-0.7-1.4-1.3-0.2-0.5-0.6-0.6
Cocaine response after cond. not corrected0.20.21.1-0.2-0.2-0.10.3-0.6-0.5-0.2-1.0-0.90.30.0-0.1-0.0
Cocaine response before conditioning1.41.75.52.31.11.3-1.31.21.11.21.11.11.21.21.21.2
Saline control response4.25.77.8-1.7-2.1-2.82.5-2.3-2.2-2.5-2.4-2.4-2.4-2.5-2.5-2.5
Bone: connectivity density0.00.00.1-0.00.10.1-0.10.20.20.20.30.30.20.20.20.2
Bone: cortical apparent density0.60.81.6-0.30.01.3-0.90.50.51.00.60.51.21.11.11.1
Bone: cortical area0.30.40.7-0.8-0.4-0.80.6-0.4-0.4-0.7-0.3-0.4-0.8-0.7-0.7-0.7
Bone: cortical porosity0.60.62.10.41.50.3-0.61.01.00.51.11.00.20.40.40.4
Bone: cortical porosity0.40.51.70.41.30.3-0.60.90.80.51.01.00.20.40.40.4
Bone: cortical thickness0.10.21.4-1.2-0.3-0.50.4-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.4
Bone: cortical thickness0.20.20.6-0.10.8-0.2-0.10.60.6-0.00.60.6-0.5-0.2-0.1-0.1
Bone: cortical tissue density0.60.81.8-0.20.01.3-1.00.50.51.00.60.61.31.21.21.2
Condit. Reinf. active minus inactive responses4.14.64.91.82.22.1-2.12.22.12.22.22.22.12.22.22.2
Condit. Reinf. active-inactive response ratio3.63.94.31.92.12.1-1.92.01.92.01.91.91.92.02.02.0
Condit. Reinf. active responses3.13.84.72.02.01.8-1.92.12.01.92.22.11.71.91.91.9
Condit. Reinf. inactive responses0.20.20.40.20.30.5-0.50.50.50.50.60.60.30.40.40.4
Incentive salience index mean2.32.93.71.51.81.6-1.61.81.71.61.91.91.51.61.61.6
Condit. Reinf. lever presses0.20.30.60.50.70.4-0.40.60.60.40.80.80.40.40.40.4
Condit. Reinf. active minus inactive responses0.81.12.1-1.5-1.0-1.01.0-0.9-0.9-1.0-1.0-1.0-1.1-1.0-1.0-1.0
Condit. Reinf. active-inactive response ratio0.70.81.2-1.1-1.0-0.70.8-0.9-0.9-0.9-0.9-0.9-0.8-0.8-0.8-0.8
Condit. Reinf. active responses0.40.61.5-1.2-0.6-1.00.7-0.5-0.5-0.8-0.6-0.6-0.9-0.8-0.8-0.8
Condit. Reinf. inactive responses0.20.30.60.30.8-0.0-0.50.70.70.50.70.60.20.30.40.4
Condit. Reinf. lever presses2.63.65.20.92.01.7-2.02.22.21.92.32.21.51.71.81.8
Condit. Reinf. lever reinforcers received0.10.10.7-0.8-0.1-0.50.20.00.0-0.20.0-0.0-0.4-0.3-0.3-0.3
Conditioned reinforcement - actives0.91.53.81.91.51.5-1.21.11.21.10.91.01.11.01.01.0
Conditioned reinforcement - inactives0.30.42.7-1.7-0.5-0.00.5-0.8-0.8-0.4-0.7-0.6-0.2-0.2-0.3-0.2
Conditioned locomotion0.70.91.2-0.8-0.9-0.91.1-1.0-1.0-1.0-1.1-1.1-0.9-0.9-0.9-0.9
Patch foraging indifference point 0 sec2.75.06.1-1.1-2.2-2.32.4-2.2-2.2-2.4-2.1-2.2-2.5-2.4-2.4-2.4
Patch foraging indifference point AUC1.62.23.6-0.9-1.4-1.91.5-1.3-1.3-1.6-1.1-1.2-1.9-1.7-1.7-1.7
Delay disc. indifference point, 0s delay0.90.94.02.00.81.1-0.80.70.80.90.40.51.10.90.90.9
Delay disc. indifference point, 16s delay0.40.55.52.3-0.10.00.10.10.3-0.3-0.1-0.1-0.4-0.4-0.4-0.4
Delay disc. indifference point, 2s delay0.20.31.11.1-0.6-0.10.6-0.2-0.2-0.5-0.4-0.5-0.4-0.4-0.4-0.4
Delay disc. indifference point, 24s delay0.40.44.32.1-0.20.4-0.10.50.4-0.00.30.3-0.2-0.1-0.1-0.1
Delay disc. indifference point, 4s delay0.40.41.81.4-0.11.3-0.30.30.30.50.10.00.70.60.60.6
Delay disc. indifference point, 8s delay0.20.22.41.6-0.10.3-0.0-0.1-0.20.0-0.1-0.20.1-0.0-0.10.0
Indifference point function ln k0.20.30.60.60.60.8-0.40.30.40.60.10.10.80.70.60.7
Indifference point function log k0.20.30.60.60.60.8-0.40.30.40.60.10.10.80.70.60.7
Patch foraging total patch changes 0 sec2.75.06.1-1.4-2.2-2.32.4-2.2-2.2-2.3-2.1-2.1-2.5-2.4-2.4-2.4
Patch foraging total patch changes 12 sec2.63.44.9-1.2-1.9-2.11.8-1.7-1.7-2.0-1.5-1.5-2.2-2.1-2.0-2.0
Patch foraging total patch changes 18 sec2.23.45.8-1.4-1.5-2.11.8-1.4-1.4-2.0-1.4-1.4-2.4-2.2-2.1-2.1
Patch foraging total patch changes 24 sec0.20.40.8-0.9-0.8-0.50.6-0.4-0.5-0.6-0.0-0.2-0.8-0.7-0.6-0.6
Patch foraging total patch changes 6 sec2.03.03.5-1.3-1.9-1.61.9-1.8-1.8-1.8-1.7-1.7-1.8-1.8-1.8-1.8
Patch foraging time to switch 0 sec0.91.73.11.41.11.7-1.31.21.11.31.31.21.41.31.31.3
Patch foraging water rate 0 sec1.42.94.6-1.6-1.5-2.21.6-1.6-1.6-1.7-1.7-1.6-1.7-1.7-1.7-1.8
Patch foraging water rate 12 sec0.20.30.6-0.8-0.5-0.70.5-0.6-0.5-0.5-0.7-0.7-0.5-0.5-0.5-0.5
Patch foraging water rate 18 sec0.10.10.4-0.1-0.40.00.3-0.3-0.3-0.3-0.1-0.2-0.6-0.4-0.3-0.3
Patch foraging water rate 24 sec0.00.00.10.40.1-0.30.00.00.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2
Patch foraging water rate 6 sec0.91.33.8-1.9-1.1-1.31.0-1.0-1.0-1.1-0.9-0.9-1.2-1.1-1.0-1.0
Seeking ratio, delayed vs. immediate footshock2.42.93.7-0.5-1.8-1.91.8-1.6-1.7-1.8-1.6-1.6-1.7-1.8-1.8-1.8
Distance traveled before self-admin0.70.92.1-1.0-1.5-1.01.1-0.8-1.1-1.0-0.3-0.5-1.3-0.9-0.8-0.7
Distance traveled after self-admin0.20.20.6-0.0-0.8-0.70.3-0.4-0.7-0.4-0.1-0.2-0.4-0.3-0.3-0.3
Extensor digitorum longus weight0.93.65.60.72.11.8-2.02.22.21.82.42.41.31.61.71.6
Bone: elastic displacement2.02.33.3-1.5-1.6-1.41.5-1.7-1.6-1.4-1.8-1.8-1.2-1.4-1.4-1.4
Bone: elastic work0.81.01.5-1.2-1.2-0.90.9-1.1-1.1-0.9-1.1-1.1-0.7-0.8-0.9-0.9
Bone: endosteal estimation0.10.10.30.2-0.5-0.30.2-0.3-0.3-0.3-0.0-0.1-0.6-0.5-0.4-0.4
Bone: endosteal perimeter0.10.30.90.3-0.1-0.70.4-0.1-0.2-0.60.10.0-1.0-0.7-0.7-0.7
Epididymis fat weight1.86.29.6-1.1-2.4-2.72.6-2.2-2.2-2.7-2.3-2.3-3.1-2.8-2.8-2.7
Delta time in closed arm before/after self-admin0.30.32.31.5-0.2-1.00.2-0.1-0.1-0.3-0.3-0.3-0.2-0.4-0.4-0.4
Delta time in open arm before/after self-admin0.60.66.6-2.6-0.30.00.2-0.5-0.50.0-0.3-0.40.20.30.30.3
Diff in mean of infusions in LGA sessions0.60.71.00.40.80.9-0.71.00.90.81.01.00.70.80.80.8
Delay discount exponential model param0.50.56.0-2.50.0-0.70.1-0.3-0.3-0.1-0.0-0.0-0.2-0.1-0.1-0.1
Extinction: sum of active levers before priming0.60.61.1-0.61.00.3-1.00.50.70.90.50.61.01.00.90.9
Active lever presses in extinction session 60.00.00.60.80.00.0-0.00.0-0.0-0.00.00.0-0.0-0.1-0.1-0.1
Bone: final force1.11.82.91.01.41.0-1.41.61.51.21.71.71.01.11.21.2
Bone: final moment0.50.81.30.80.80.6-0.91.00.90.81.21.10.70.80.80.8
Food consumed during 24 hour testing period0.20.31.20.6-0.3-0.70.3-0.1-0.1-0.50.0-0.0-1.1-0.8-0.7-0.7
Glucose1.21.93.40.80.81.7-1.40.90.91.61.11.01.81.71.71.7
Heart weight0.10.10.5-0.70.00.4-0.0-0.2-0.00.1-0.4-0.30.30.20.20.2
Delay discount hyperbolic model param0.50.66.1-2.5-0.0-0.80.2-0.4-0.4-0.2-0.1-0.1-0.3-0.2-0.2-0.2
Intermittent access intake day 1-15 change1.22.43.61.91.41.9-1.71.31.31.61.41.41.51.51.51.5
Intermittent access intake escalation1.32.74.22.01.52.0-1.81.41.41.71.51.51.71.61.61.6
Intermittent access intake escalation 21.01.23.01.31.01.7-1.10.80.81.10.80.91.11.01.01.0
Intermitt. access day 1 inactive lever presses0.00.10.30.60.20.4-0.2-0.00.00.2-0.3-0.20.30.20.10.2
Intermitt. access day 15 inactive lever presses0.10.10.20.20.20.5-0.30.40.30.30.40.40.30.40.40.4
Intermitt. access escalation Index0.30.51.01.0-0.9-0.90.6-0.6-0.8-0.6-0.5-0.5-0.5-0.6-0.6-0.6
Intermittent access day 1 total infusions0.30.44.42.10.60.4-0.30.10.20.2-0.3-0.10.50.20.10.1
Intermittent access day 15 total infusions2.03.010.53.21.72.0-1.71.21.31.61.01.11.81.61.51.5
Intermittent access terminal intake (last 3 days)3.24.211.03.32.12.5-2.11.71.82.01.41.62.11.91.81.9
Intermittent access total infusions2.93.411.73.42.02.0-1.81.51.71.71.21.31.81.61.51.5
Intermittent access day 1 locomotion1.31.73.20.6-1.2-1.31.2-1.5-1.4-1.3-1.8-1.7-0.9-1.2-1.3-1.3
Intermittent access day 15 total locomotion0.30.61.60.2-0.7-0.20.7-1.1-1.0-0.6-1.3-1.2-0.3-0.5-0.6-0.6
Intermittent access total locomotion0.20.20.90.6-0.20.10.3-0.5-0.5-0.3-0.9-0.80.2-0.1-0.2-0.2
Intermittent access standard deviation0.20.40.8-0.9-0.3-0.10.6-0.8-0.7-0.5-0.8-0.8-0.4-0.5-0.5-0.5
Left kidney weight1.57.210.10.92.82.5-2.73.13.12.73.23.22.12.62.72.7
Right kidney weight1.67.510.40.82.92.7-2.73.23.22.73.23.22.02.62.72.7
Cocaine induced anxiety2.84.05.1-2.3-2.2-1.72.1-2.2-2.1-2.0-2.3-2.2-1.6-1.8-1.8-1.8
Post-drug Anxiety0.70.81.5-0.9-1.1-0.50.9-1.0-0.9-0.8-1.2-1.1-0.5-0.7-0.7-0.7
Baseline Anxiety1.92.26.72.61.41.7-1.51.41.41.41.21.21.31.31.31.3
Tail length0.00.21.21.10.6-0.1-0.20.40.50.00.30.3-0.3-0.2-0.2-0.2
Length with tail0.10.51.2-1.1-0.1-0.90.6-0.3-0.2-0.7-0.3-0.4-1.1-0.9-0.8-0.8
Length without tail0.51.73.4-1.8-1.1-1.41.2-1.2-1.1-1.3-1.3-1.2-1.4-1.3-1.3-1.3
Times rat made contact with spout1.21.42.1-0.5-1.2-1.31.1-1.1-1.2-1.3-0.9-1.0-1.4-1.4-1.4-1.4
Lifetime Intake2.53.111.93.51.91.9-1.71.51.51.51.11.31.61.41.31.4
Liver weight, left0.20.40.8-0.9-0.7-0.70.6-0.6-0.6-0.6-0.4-0.4-0.6-0.6-0.5-0.6
Liver weight, right0.30.61.1-0.4-0.4-1.10.8-0.5-0.4-0.8-0.7-0.7-1.0-0.9-0.9-0.9
Locomotor activity2.64.15.2-2.3-1.9-2.32.1-1.9-1.8-2.1-1.8-1.8-2.1-2.1-2.0-2.1
Locomotor testing distance1.93.54.7-1.8-1.6-2.22.0-1.7-1.7-2.0-1.8-1.8-1.9-1.9-1.9-2.0
Locomotor testing rearing0.40.74.5-2.1-0.4-1.10.8-0.5-0.4-0.7-0.6-0.5-0.7-0.6-0.6-0.6
Locomotion in novel chamber2.22.94.7-0.6-1.7-2.21.8-1.6-1.7-1.8-1.7-1.7-1.6-1.7-1.7-1.7
Locomotion in novel chamber post-restriction1.52.53.00.1-1.6-1.61.6-1.5-1.5-1.6-1.7-1.7-1.5-1.7-1.7-1.7
Fecal boli incidents, locomotor time 10.91.32.4-1.1-1.2-0.91.0-1.6-1.4-1.0-0.8-0.9-1.2-1.2-1.2-1.3
Change in fecal boli incidents, locomotor task0.40.40.70.70.70.6-0.70.40.30.70.30.30.80.80.80.8
Time >=10cm from walls, locomotor time 10.50.51.10.2-0.5-0.90.5-1.0-1.0-0.6-0.8-0.9-0.6-0.7-0.7-0.7
Bouts of movement, locomotor time 10.10.20.5-0.5-0.3-0.30.3-0.6-0.7-0.2-0.6-0.50.1-0.1-0.2-0.2
Total resting periods, locomotor time 10.10.10.3-0.2-0.10.10.0-0.5-0.50.1-0.3-0.20.30.10.10.1
Rest time, locomotor task time 10.10.20.8-0.10.30.4-0.3-0.3-0.30.4-0.00.00.90.50.50.4
Distance moved, locomotor task time 10.10.20.4-0.3-0.3-0.30.4-0.1-0.1-0.4-0.4-0.5-0.6-0.5-0.4-0.4
Vertical activity count, locomotor time 10.40.92.10.8-1.0-0.90.9-0.3-0.3-1.1-0.7-0.7-1.5-1.2-1.2-1.2
Time >=10cm from walls, locomotor time 20.20.30.6-0.60.80.4-0.60.20.30.70.20.30.80.70.70.6
Bouts of movement, locomotor time 20.71.11.61.30.91.1-1.01.11.31.00.91.11.01.01.01.0
Total resting periods, locomotor time 20.81.41.81.30.91.3-1.21.21.31.11.11.21.21.11.11.1
Rest time, locomotor task time 20.50.61.20.70.71.1-1.00.10.30.90.70.71.00.90.80.8
Distance moved, locomotor task time 20.91.14.1-2.0-0.8-1.01.1-0.7-0.7-1.0-1.2-1.2-0.9-0.8-0.8-0.8
Vertical activity count, locomotor time 20.91.31.8-0.8-1.3-1.21.3-0.4-0.5-1.3-1.2-1.2-1.4-1.2-1.2-1.2
Light reinforcement 11.94.67.3-1.4-1.9-2.42.3-1.8-1.9-2.4-1.7-1.7-2.7-2.5-2.4-2.4
Light reinforcement 22.13.24.4-0.3-2.1-1.32.0-1.8-1.9-2.0-1.5-1.6-2.1-2.0-2.0-2.0
Bone: marrow area0.00.10.20.3-0.5-0.30.2-0.2-0.3-0.30.0-0.0-0.5-0.4-0.4-0.3
Bone: maximum diameter0.40.71.1-0.6-0.7-1.00.8-0.6-0.7-0.9-0.5-0.6-1.1-1.0-0.9-0.9
Bone: maximum force0.30.50.90.40.80.5-0.80.90.80.71.00.90.60.70.70.7
Bone: maximum moment0.00.10.20.10.20.2-0.30.30.20.20.40.30.20.20.30.2
Mean time between licks in bursts0.00.00.10.1-0.20.30.2-0.0-0.1-0.10.10.0-0.3-0.2-0.2-0.1
Mean num. licks in bursts0.00.00.20.40.1-0.1-0.20.10.10.10.30.3-0.1-0.0-0.0-0.0
Cd content in liver0.10.10.3-0.00.50.4-0.20.30.30.20.10.10.30.30.30.3
Co content in liver0.00.00.10.20.30.2-0.20.20.20.20.10.10.20.20.20.2
Cu content in liver1.31.65.42.31.41.0-1.11.31.31.11.11.10.91.01.01.0
Fe content in liver2.02.43.0-0.7-1.7-1.71.6-1.7-1.7-1.6-1.6-1.6-1.4-1.5-1.5-1.6
K content in liver0.10.10.20.10.10.3-0.30.10.10.3-0.1-0.10.40.30.30.3
Mg content in liver0.50.50.7-0.4-0.8-0.70.7-0.7-0.7-0.6-0.9-0.9-0.6-0.7-0.7-0.7
Mn content in liver0.80.92.0-1.4-1.2-0.70.9-1.0-1.0-0.9-1.0-1.0-0.7-0.8-0.8-0.8
Na content in liver0.40.41.0-0.9-0.90.00.2-0.8-0.80.0-1.0-1.00.30.10.00.1
Rb content in liver0.70.82.71.71.20.6-0.71.01.00.60.90.90.60.50.50.5
Se content in liver0.10.10.4-0.40.40.2-0.40.40.40.20.60.60.00.20.20.2
Sr content in liver0.90.81.3-0.9-0.7-1.00.9-0.7-0.7-1.0-0.4-0.4-1.2-1.0-1.0-1.0
Zn content in liver1.71.93.01.31.71.4-1.41.41.41.41.21.21.21.31.31.4
Bone: minimum diameter0.10.20.3-0.5-0.4-0.60.3-0.4-0.4-0.5-0.2-0.2-0.5-0.5-0.5-0.5
Time in familiar zone, hab. session 10.40.40.6-0.8-0.7-0.30.4-0.8-0.7-0.5-0.7-0.7-0.4-0.5-0.5-0.4
Time in novel zone, hab. session 10.20.20.40.30.60.3-0.40.60.60.50.40.50.50.50.50.4
Total zone transitions, hab. session 10.81.11.7-0.8-0.9-1.31.1-0.9-1.0-1.1-0.8-0.8-1.1-1.1-1.1-1.1
Total locomotion distance, hab. session 10.91.32.2-0.4-1.0-1.51.3-1.0-1.0-1.2-0.9-0.9-1.4-1.3-1.3-1.3
Locomotion velocity, hab. session 11.11.62.8-0.4-1.0-1.71.4-1.0-1.1-1.4-0.9-0.9-1.5-1.4-1.4-1.4
Time in familiar zone, hab. session 20.91.01.5-0.6-1.1-0.71.1-1.2-1.2-1.0-1.2-1.2-0.7-0.9-0.9-0.9
Time in novel zone, hab. session 24.14.24.91.02.12.0-2.22.12.12.22.02.02.22.22.22.2
Total zone transitions, hab. session 21.82.33.3-1.5-1.4-1.81.7-1.3-1.3-1.6-1.1-1.1-1.7-1.7-1.6-1.7
Total locomotion distance, hab. session 20.91.22.0-0.7-0.8-1.41.2-0.8-0.8-1.2-0.7-0.7-1.4-1.3-1.3-1.3
Locomotion velocity, hab. session 20.81.12.1-0.7-0.8-1.41.2-0.7-0.8-1.2-0.6-0.6-1.4-1.3-1.3-1.3
Novel to familiar place preference ratio1.92.13.31.61.21.8-1.51.21.11.51.11.11.71.61.61.6
Novelty place preference3.03.24.61.71.52.2-1.81.51.51.91.41.42.12.02.02.0
Time in novel zone, NPP test2.82.94.31.81.52.0-1.71.41.41.81.31.42.11.91.91.9
Total zone transitions, NPP test1.62.33.0-1.2-1.5-1.71.6-1.3-1.4-1.6-1.2-1.2-1.7-1.7-1.6-1.7
Total locomotion distance, NPP test0.81.01.9-0.6-0.9-1.31.1-0.7-0.7-1.1-0.6-0.6-1.4-1.2-1.2-1.2
Locomotion velocity, NPP test0.60.91.7-0.6-0.8-1.21.1-0.6-0.6-1.0-0.5-0.5-1.3-1.1-1.1-1.1
Intraocular pressure0.70.91.70.11.10.8-0.91.31.30.81.21.30.60.80.90.8
Delta distance traveled before/after self-admin0.30.40.7-0.30.50.5-0.70.40.40.70.40.40.80.70.70.7
Delta ambulatory time before/after self-admin0.60.81.40.71.00.9-1.00.70.71.00.50.51.21.00.90.9
Parametrial fat weight7.016.518.0-3.8-4.2-3.84.0-4.2-4.2-4.1-4.1-4.1-4.0-4.1-4.1-4.1
Pavlov. Cond. lever latency0.10.10.40.2-0.4-0.10.1-0.6-0.5-0.2-0.6-0.6-0.1-0.2-0.2-0.2
Pavlov. Cond. magazine entry latency0.91.12.70.81.10.5-0.91.41.30.91.61.60.40.70.80.7
Pavlov. Cond. change in total contacts0.91.01.70.80.90.9-0.91.21.10.91.31.20.80.90.90.9
Pavlov. Cond. index score0.60.82.20.50.90.4-0.71.31.20.71.51.40.30.60.60.6
Pavlov. Cond. latency score0.50.61.80.50.80.3-0.61.21.00.61.31.20.20.50.50.5
Pavlov. Cond. lever contacts0.60.71.40.00.90.6-0.71.11.10.81.21.10.60.70.80.7
Pavlov. Cond. magazine entry number0.81.12.2-0.8-1.1-0.61.0-1.3-1.3-0.9-1.5-1.4-0.5-0.8-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.20.20.30.2-0.4-0.40.4-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.70.92.20.70.90.5-0.71.31.20.71.51.40.30.60.70.6
Pavlov. Cond. response bias0.50.61.40.40.80.4-0.61.11.00.61.21.10.30.50.60.5
Pavlov. Cond. lever latency1.31.82.7-0.5-1.3-1.21.5-1.6-1.5-1.4-1.7-1.6-1.1-1.3-1.3-1.3
Pavlov. Cond. magazine entry latency3.84.55.81.62.22.1-2.12.32.32.12.42.41.92.02.12.0
Pavlov. Cond. change in total contacts2.03.15.60.61.71.7-1.82.12.01.72.42.31.31.61.71.6
Pavlov. Cond. index score3.64.86.61.42.22.1-2.32.42.42.22.62.51.92.12.12.1
Pavlov. Cond. latency score3.64.86.51.42.22.1-2.32.42.42.22.52.51.92.12.22.1
Pavlov. Cond. lever contacts1.82.43.90.91.61.4-1.71.81.81.52.01.91.21.41.51.4
Pavlov. Cond. magazine entry number5.77.08.8-1.7-2.7-2.72.7-2.9-2.8-2.6-3.0-2.9-2.4-2.6-2.6-2.6
Pavlov. Cond. intertrial magazine entries4.46.68.6-2.1-2.6-2.92.6-2.5-2.5-2.6-2.4-2.4-2.7-2.7-2.7-2.7
Pavlov. Cond. lever-magazine prob. diff.4.05.47.01.62.32.3-2.42.62.52.32.72.62.02.22.32.2
Pavlov. Cond. response bias3.24.46.21.22.11.9-2.22.42.32.12.52.41.72.02.02.0
Time in closed arm before self-admin3.24.14.7-2.1-2.1-1.82.0-2.2-2.1-2.0-2.1-2.0-2.0-2.0-2.0-2.0
Time in closed arm after self-admin3.03.24.4-0.3-2.0-2.11.9-1.8-1.9-1.9-1.8-1.8-1.7-1.8-1.8-1.8
Time in open arm before self-admin2.32.54.02.01.71.1-1.51.91.91.42.01.90.91.21.31.2
Time in open arm after self-admin0.50.61.2-1.10.70.5-0.70.60.70.80.80.60.70.80.90.9
Bone: periosteal estimation0.20.40.8-0.5-0.7-0.80.6-0.5-0.5-0.7-0.2-0.3-0.9-0.8-0.7-0.8
Bone: periosteal perimeter0.50.91.8-0.5-0.6-1.31.0-0.6-0.7-1.1-0.5-0.5-1.4-1.2-1.2-1.2
Bone: post-yield work0.50.81.10.2-0.8-0.90.9-1.0-1.0-0.9-1.0-1.0-0.7-0.8-0.9-0.8
Progressive ratio test 1 active lever presses4.15.015.94.02.41.8-2.22.32.32.02.12.21.81.81.71.8
Progressive ratio test 1 breakpoint3.74.514.43.82.31.6-2.12.22.21.92.02.01.61.71.61.7
Progressive ratio test 1 inactive lever presses0.10.21.51.20.30.3-0.40.10.10.3-0.1-0.00.50.30.20.2
Progressive ratio test 2 active lever presses2.93.414.43.82.01.7-1.91.51.61.71.21.31.71.51.41.4
Progressive ratio test 2 breakpoint3.13.514.33.82.01.8-1.91.51.61.71.31.41.71.51.41.5
Progressive ratio test 2 inactive lever presses0.10.21.21.10.20.4-0.40.20.20.3-0.10.00.60.40.30.4
Incentive Sensitization - Responses0.91.36.52.51.21.1-1.20.70.81.00.50.61.10.80.80.8
Incentive Sensitization - Breakpoint1.11.57.22.71.31.3-1.30.80.91.10.60.71.20.90.90.9
Sum of active levers in priming session hrs 5-60.30.30.5-0.10.70.2-0.50.60.70.50.50.50.60.60.60.6
Progressive ratio0.20.31.1-0.60.3-0.00.01.00.9-0.11.00.9-0.30.00.10.1
Food seeking constrained by brief footshock1.41.72.4-0.21.31.2-1.31.41.31.41.61.41.11.31.41.4
Seeking ratio, punishment vs. effort0.30.40.90.10.60.9-0.80.10.20.90.20.21.00.80.80.8
Retroperitoneal fat weight6.427.430.0-3.9-5.5-5.25.4-5.4-5.4-5.4-5.1-5.1-5.3-5.4-5.4-5.3
Reaction time number correct1.22.25.22.31.71.1-1.51.51.61.41.11.21.41.41.41.4
Reaction time mean minus median0.71.82.9-0.41.70.8-1.21.61.61.21.71.71.11.21.31.2
Reaction time mean minus median AUC0.61.63.0-0.41.70.6-1.11.61.61.11.71.70.91.11.21.1
Reaction time num false alarms0.10.20.40.70.60.5-0.40.30.40.30.00.10.50.40.30.4
Reaction time num false alarms AUC0.00.10.40.60.3-0.1-0.0-0.00.1-0.1-0.3-0.20.0-0.1-0.1-0.1
Reaction time trials correct on left1.22.25.22.31.71.1-1.51.51.61.41.11.21.41.41.41.4
Reaction time trials on left1.32.45.62.41.81.1-1.61.51.61.51.11.31.41.41.41.4
Reaction time mean0.20.32.8-1.70.20.2-0.00.30.30.10.50.40.10.30.40.4
Reaction time mean AUC0.30.41.9-1.40.50.4-0.30.50.50.40.70.60.50.60.70.6
Median of all reaction times0.20.22.8-1.7-0.3-0.00.4-0.1-0.1-0.3-0.0-0.1-0.2-0.10.0-0.0
Reaction time omissions0.20.31.51.20.4-0.40.00.40.3-0.20.50.5-0.6-0.4-0.4-0.4
Reaction time false alarm rate0.40.50.7-0.7-0.5-0.60.7-0.7-0.7-0.8-0.9-0.8-0.6-0.7-0.7-0.7
Reaction time premature initiation rate1.21.62.7-0.30.91.4-1.31.31.21.31.61.61.21.31.41.3
Reaction time premature initiations2.23.94.70.91.81.9-2.22.12.02.12.22.21.92.12.12.0
Std. dev. reaction times0.30.51.3-1.10.80.3-0.40.80.80.50.90.80.50.70.70.6
Reaction time trials completed1.32.45.62.41.81.1-1.61.51.61.51.11.31.41.41.41.4
Reaction time trials AUC1.22.45.42.31.81.1-1.61.51.61.51.11.31.51.41.41.4
Run reversals in cocaine runway, females2.72.76.4-2.5-1.5-1.81.3-1.9-1.9-1.3-1.5-1.6-1.4-1.4-1.4-1.4
Run reversals in cocaine runway, males0.50.50.9-0.6-0.6-0.40.6-1.0-0.9-0.6-0.5-0.5-0.8-0.8-0.8-0.8
Latency to leave start box in cocaine runway0.40.43.7-1.90.10.3-0.3-0.2-0.00.5-0.00.00.60.60.60.6
Latency to leave start box in cocaine runway, F0.81.02.5-0.20.91.2-1.10.30.51.20.20.31.61.31.21.2
Latency to leave start box in cocaine runway, M1.91.812.7-3.6-1.2-1.31.1-0.7-0.7-1.0-0.6-0.5-1.2-0.9-0.8-0.8
Std. dev. time between licks in bursts1.72.43.4-1.3-1.6-1.51.7-1.4-1.4-1.6-1.2-1.3-1.9-1.7-1.7-1.7
Total sessions with >9 infusions2.12.510.23.21.61.5-1.51.51.51.41.31.31.21.21.21.2
Short access day 1 total inactive lever presses0.00.00.10.1-0.10.40.0-0.2-0.2-0.0-0.3-0.20.20.00.0-0.0
Short access day 10 total inactive lever presses0.20.41.3-1.1-0.6-0.20.6-0.6-0.6-0.5-0.7-0.7-0.4-0.5-0.5-0.5
Short access day 1 total infusions0.81.18.62.91.01.1-0.80.60.70.70.40.40.70.50.40.4
Short access day 10 total infusions0.81.17.62.81.11.1-0.70.80.80.60.30.50.70.50.50.5
Short access total infusions2.73.514.73.81.91.9-1.71.71.71.61.31.41.51.41.31.3
Short access day 1 locomotion0.30.42.91.70.50.5-0.60.40.40.50.40.40.40.40.30.3
Short access day 10 total locomotion1.42.64.0-0.7-1.7-1.31.8-1.7-1.7-1.7-2.0-1.9-1.3-1.6-1.7-1.6
Short access total locomotion0.30.40.80.5-0.6-0.40.6-0.6-0.7-0.6-0.9-0.8-0.3-0.5-0.6-0.6
One hour access (0.3 mA shock)1.82.18.52.91.51.6-1.31.31.31.21.01.11.21.01.01.0
Compulsive drug intake0.20.21.3-1.2-0.5-0.00.4-0.3-0.5-0.4-0.1-0.2-0.5-0.4-0.3-0.4
One hour access (shock baseline)1.42.110.43.21.71.3-1.41.11.21.20.60.81.41.11.11.1
Social response proportion0.80.94.02.01.11.1-0.80.80.90.80.60.60.80.70.70.7
Social responses0.00.10.40.60.4-0.2-0.00.30.30.10.10.1-0.0-0.0-0.0-0.0
Social time0.10.11.21.10.60.0-0.10.20.40.1-0.00.00.10.00.00.1
Soleus weight0.20.71.7-1.3-1.1-0.70.7-0.8-0.8-0.8-0.4-0.6-0.9-0.8-0.7-0.8
Bone: stiffness3.65.88.11.72.82.1-2.52.72.62.32.82.81.92.22.32.3
Tibialis anterior weight0.41.42.80.71.70.8-1.11.61.70.91.61.60.40.70.80.8
Time to tail flick, vehicle, before self-admin0.70.73.11.80.90.8-0.80.60.50.80.70.60.80.70.60.6
Time to tail flick, vehicle, after self-admin0.81.12.41.6-0.5-0.91.0-0.9-0.8-1.0-1.3-1.2-0.8-1.1-1.1-1.1
Time to tail flick, test, before self-admin2.52.53.60.3-1.5-1.51.7-1.4-1.4-1.8-1.6-1.5-1.9-1.9-1.9-1.9
Time to tail flick, test, after self-admin0.10.11.01.00.1-0.40.10.10.1-0.2-0.00.1-0.4-0.4-0.4-0.4
Delta time to tail flick, vehicle, before/after SA0.70.71.10.3-0.5-1.00.9-0.5-0.3-0.9-1.0-0.8-0.9-1.0-1.0-1.0
Delta time to tail flick, test, before/after SA1.11.21.70.91.00.9-1.21.21.11.11.31.30.91.01.01.0
Tibia length0.00.10.3-0.60.20.1-0.40.40.30.20.50.50.10.20.20.2
Ambulatory time before self-admin1.11.73.2-1.3-1.8-1.41.4-1.2-1.4-1.3-0.6-0.8-1.6-1.3-1.2-1.2
Ambulatory time after self-admin0.50.51.50.5-1.2-0.70.7-0.8-1.1-0.7-0.3-0.5-0.8-0.6-0.6-0.6
Bone: tissue strength0.20.20.70.4-0.60.7-0.4-0.3-0.30.4-0.3-0.30.90.60.50.5
Total heroin consumption1.01.11.81.01.11.3-1.10.80.81.10.70.71.31.21.21.2
Bone: trabecular number0.30.51.2-1.1-0.7-0.80.8-0.7-0.8-0.7-0.6-0.6-0.6-0.6-0.6-0.7
Bone: trabecular spacing0.00.10.10.0-0.2-0.20.1-0.2-0.2-0.2-0.4-0.3-0.3-0.3-0.3-0.3
Bone: trabecular thickness0.50.71.0-0.01.00.7-0.80.90.90.81.01.00.80.80.80.8
Bone: trabecular tissue density0.60.91.20.60.81.0-1.00.90.91.00.90.91.11.11.01.0
Water consumed over 24 hours0.20.30.7-0.4-0.5-0.70.5-0.4-0.5-0.6-0.2-0.3-0.8-0.7-0.7-0.7
Number of responses in last shaping day0.50.61.1-0.50.70.2-0.70.80.70.81.01.00.60.80.90.9