Hub : Genes

Tomm40

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Tomm40 0.17 0.11 2.8e-03 0.06 0.06 0.01 0.04 1.3e-02 1.8e-02 2.2e-01 4.2e-02
2 Liver mRNA stability Tomm40 0.03 0.03 8.5e-04 0.02 0.01 0.01 0.01 1.5e-03 2.0e-02 4.0e-02 3.3e-02
3 pVTA gene expression Tomm40 0.07 0.05 3.1e-04 0.01 0.03 0.02 0.02 2.1e-02 4.0e-03 4.5e-03 6.0e-03
4 NAcc gene expression Tomm40 0.05 0.03 8.4e-09 0.05 0.05 0.05 0.05 1.3e-07 7.1e-08 1.0e-07 1.6e-07
5 Liver gene expression Tomm40 0.02 0.02 7.2e-03 0 0.01 0 0 1.9e-01 2.9e-02 1.5e-01 1.0e-01
6 Adipose gene expression Tomm40 0.02 0.02 5.0e-03 0.01 0.01 0.01 0.01 3.2e-02 6.9e-03 6.6e-02 3.0e-02
7 BLA gene expression Tomm40 0.15 0.1 1.3e-07 0.11 0.09 0.08 0.08 2.3e-06 2.0e-05 4.9e-05 4.8e-05
8 Brain gene expression Tomm40 0.15 0.08 0.0e+00 0.18 0.17 0.17 0.17 1.0e-16 1.0e-15 4.0e-16 5.2e-16
9 PL gene expression Tomm40 0.09 0.06 1.2e-10 0.11 0.09 0.09 0.1 9.6e-12 1.9e-10 1.9e-10 9.4e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.10.10.0-0.3-0.3-0.2-0.2-0.2-0.3-0.4-0.4
Area under the delay curve2.12.43.31.41.61.21.31.51.51.61.81.8
BMI with tail0.82.84.4-2.1-1.9-1.8-1.7-1.5-1.6-1.5-1.6-1.4
BMI without tail0.61.83.0-1.7-1.4-1.4-1.4-1.3-1.4-1.1-1.2-1.0
Body weight1.35.66.6-2.6-2.5-2.5-2.4-2.2-2.2-2.2-2.4-2.2
Weight adjusted by age0.00.00.1-0.00.20.00.0-0.0-0.00.30.10.0
Bone surface0.50.91.4-0.8-1.2-1.0-0.9-0.8-0.8-1.0-1.0-1.0
Bone volume0.30.50.8-0.5-0.7-0.8-0.8-0.6-0.6-0.9-0.8-0.9
Breakpoint value in progressive ratio session2.32.83.31.81.81.61.61.71.71.71.51.6
Number of licking bursts1.22.02.8-1.0-0.7-1.5-1.6-1.5-1.3-1.6-1.7-1.7
Context. condit. distance diff. score0.20.20.4-0.6-0.6-0.5-0.4-0.4-0.4-0.3-0.5-0.5
Locomotion velocity, session 10.10.10.20.40.40.20.20.30.40.20.20.1
Locomotion distance, session 10.10.10.4-0.0-0.2-0.3-0.3-0.3-0.2-0.4-0.6-0.7
Locomotion velocity, session 20.60.71.0-0.2-0.2-0.8-0.9-1.0-0.9-1.0-0.9-1.0
Locomotion distance, session 20.30.40.80.0-0.1-0.5-0.6-0.7-0.7-0.9-0.8-0.9
Locomotion velocity, session 30.10.10.3-0.3-0.3-0.3-0.4-0.5-0.5-0.3-0.3-0.3
Locomotion distance, session 30.91.01.61.31.21.21.10.80.70.90.90.9
Stereotopy head waving bouts, day 30.60.71.7-1.3-1.2-0.7-0.7-1.0-1.0-0.5-0.3-0.3
Stereotopy head waving duration, day 31.01.22.4-1.6-1.3-1.1-1.1-1.1-1.2-0.9-0.7-0.7
Locomotion velocity, session 70.10.10.20.50.50.20.20.20.20.10.00.0
Locomotion distance, session 70.10.10.1-0.2-0.2-0.4-0.4-0.3-0.3-0.3-0.3-0.4
Stereotopy head waving bouts, day 71.01.11.8-1.1-1.3-1.0-1.0-1.1-1.1-1.0-1.0-1.0
Stereotopy head waving duration, day 70.70.91.5-1.0-1.2-0.9-0.9-0.9-0.9-0.8-0.8-0.8
Locomotion velocity, session 80.10.10.20.20.50.40.30.10.10.20.30.3
Locomotion distance, session 80.10.10.2-0.1-0.0-0.2-0.2-0.2-0.2-0.3-0.4-0.4
Degree of sensitization distance0.91.01.9-1.4-1.2-1.2-1.1-0.7-0.7-0.8-0.7-0.7
Degree of sensitization stereotypy1.01.11.5-0.9-1.2-1.0-1.0-1.1-1.1-1.1-1.0-1.1
Conditioned locomotion0.10.10.40.40.50.60.50.0-0.00.20.10.2
Cocaine response after cond. corrected0.80.91.3-0.9-0.8-0.8-0.9-1.0-1.0-0.9-1.1-1.2
Cocaine response after cond. not corrected1.92.33.0-1.4-1.3-1.3-1.4-1.6-1.6-1.5-1.7-1.7
Cocaine response before conditioning1.41.72.3-1.2-1.1-1.1-1.2-1.5-1.5-1.4-1.4-1.3
Saline control response1.72.22.6-1.4-1.5-1.6-1.6-1.5-1.5-1.5-1.4-1.4
Bone: connectivity density0.00.00.10.0-0.4-0.1-0.1-0.0-0.0-0.2-0.1-0.1
Bone: cortical apparent density0.10.10.20.10.40.20.20.30.40.50.20.3
Bone: cortical area1.21.92.3-1.2-1.0-1.5-1.5-1.4-1.3-1.5-1.4-1.4
Bone: cortical porosity0.50.61.20.70.71.11.00.40.40.60.80.7
Bone: cortical porosity0.10.20.40.30.30.70.50.1-0.00.30.50.5
Bone: cortical thickness0.40.70.9-0.7-0.5-0.9-0.9-0.9-0.9-0.9-0.8-0.8
Bone: cortical thickness1.41.61.9-1.4-1.2-1.2-1.3-1.3-1.3-1.3-1.2-1.2
Bone: cortical tissue density0.10.20.30.20.50.30.30.40.40.60.30.4
Condit. Reinf. active minus inactive responses0.60.70.8-0.8-0.8-0.8-0.8-0.8-0.8-0.9-0.9-0.8
Condit. Reinf. active-inactive response ratio0.70.70.9-0.8-0.9-0.9-0.8-0.8-0.8-0.9-1.0-1.0
Condit. Reinf. active responses0.40.50.8-0.9-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.7
Condit. Reinf. inactive responses0.00.00.1-0.4-0.3-0.00.00.0-0.0-0.10.10.1
Incentive salience index mean0.30.30.5-0.4-0.4-0.5-0.5-0.6-0.6-0.7-0.7-0.7
Condit. Reinf. lever presses0.00.10.10.40.20.1-0.0-0.1-0.1-0.3-0.3-0.4
Condit. Reinf. active minus inactive responses0.20.30.5-0.7-0.5-0.4-0.4-0.5-0.5-0.4-0.6-0.6
Condit. Reinf. active-inactive response ratio0.91.01.4-1.0-0.9-0.7-0.8-1.0-1.1-1.0-1.2-1.2
Condit. Reinf. active responses0.10.10.10.10.30.40.30.20.20.40.30.4
Condit. Reinf. inactive responses1.01.32.01.01.11.01.01.11.11.21.41.4
Condit. Reinf. lever presses0.30.40.6-0.8-0.6-0.7-0.7-0.5-0.5-0.5-0.6-0.5
Condit. Reinf. lever reinforcers received0.10.10.20.20.40.40.40.30.20.40.30.4
Conditioned reinforcement - actives1.62.84.8-2.1-2.2-1.6-1.5-1.6-1.7-1.6-1.3-1.1
Conditioned reinforcement - inactives0.40.51.0-1.0-0.6-0.7-0.7-0.8-0.8-0.6-0.7-0.6
Conditioned locomotion2.73.54.6-2.0-2.2-1.8-1.8-1.9-1.9-1.8-1.8-1.7
Patch foraging indifference point 0 sec0.30.60.8-0.9-0.6-0.7-0.8-0.8-0.8-0.6-0.9-0.9
Patch foraging indifference point AUC2.33.43.8-1.9-2.0-1.8-1.9-1.9-1.9-1.7-1.7-1.7
Delay disc. indifference point, 0s delay1.51.72.41.11.21.31.31.21.21.21.51.6
Delay disc. indifference point, 16s delay1.51.62.31.21.50.91.01.31.31.11.51.5
Delay disc. indifference point, 2s delay4.24.75.32.12.11.81.92.32.32.32.32.3
Delay disc. indifference point, 24s delay0.20.30.5-0.7-0.3-0.7-0.6-0.4-0.4-0.5-0.5-0.5
Delay disc. indifference point, 4s delay0.00.00.1-0.1-0.10.00.00.0-0.00.30.40.4
Delay disc. indifference point, 8s delay2.22.53.31.61.71.31.41.51.61.51.81.8
Indifference point function ln k0.61.11.51.01.21.01.01.11.10.91.00.9
Indifference point function log k0.61.11.51.01.21.01.01.11.10.91.00.9
Patch foraging total patch changes 0 sec0.61.11.3-1.2-0.9-1.1-1.1-1.1-1.0-1.0-1.1-1.2
Patch foraging total patch changes 12 sec1.21.51.9-1.4-1.2-1.0-1.1-1.3-1.3-1.1-1.3-1.2
Patch foraging total patch changes 18 sec2.53.95.3-2.3-2.3-2.0-1.9-1.8-1.7-1.8-1.9-2.0
Patch foraging total patch changes 24 sec0.50.81.6-1.3-1.3-0.9-0.8-0.8-0.8-0.7-0.6-0.7
Patch foraging total patch changes 6 sec2.03.13.6-1.9-1.8-1.7-1.8-1.9-1.9-1.6-1.6-1.6
Patch foraging time to switch 0 sec2.55.15.92.21.82.32.42.42.42.22.22.3
Patch foraging water rate 0 sec2.85.96.7-2.4-2.2-2.5-2.5-2.6-2.6-2.3-2.3-2.4
Patch foraging water rate 12 sec0.20.40.7-0.8-0.4-0.8-0.7-0.6-0.6-0.5-0.5-0.6
Patch foraging water rate 18 sec0.20.31.1-1.1-0.5-0.7-0.7-0.5-0.4-0.3-0.3-0.5
Patch foraging water rate 24 sec0.71.01.6-1.3-1.0-1.1-1.0-1.0-1.0-0.8-0.8-0.9
Patch foraging water rate 6 sec0.91.42.0-1.4-1.0-1.4-1.3-1.0-1.0-1.0-1.1-1.2
Seeking ratio, delayed vs. immediate footshock1.92.42.71.61.61.61.61.41.41.61.41.5
Distance traveled before self-admin0.10.10.3-0.2-0.2-0.3-0.3-0.3-0.3-0.4-0.5-0.5
Distance traveled after self-admin0.30.30.80.70.90.60.60.40.50.40.50.5
Extensor digitorum longus weight1.66.47.7-2.4-2.3-2.8-2.7-2.4-2.3-2.7-2.5-2.6
Bone: elastic displacement1.01.11.40.81.01.21.21.11.00.91.21.1
Bone: elastic work0.00.00.2-0.4-0.3-0.0-0.0-0.2-0.3-0.2-0.00.0
Bone: endosteal estimation0.00.00.1-0.1-0.30.00.10.10.1-0.0-0.0-0.1
Bone: endosteal perimeter0.00.00.10.30.0-0.1-0.00.10.1-0.1-0.1-0.1
Epididymis fat weight0.41.31.91.31.41.11.11.11.11.21.01.1
Delta time in closed arm before/after self-admin0.10.00.1-0.0-0.0-0.00.10.20.30.20.40.3
Delta time in open arm before/after self-admin0.10.10.10.30.30.30.30.20.10.10.30.3
Diff in mean of infusions in LGA sessions1.21.51.81.11.01.21.31.31.31.31.21.2
Delay discount exponential model param1.51.72.3-1.2-1.4-1.0-1.1-1.3-1.3-1.4-1.5-1.5
Extinction: sum of active levers before priming0.20.20.20.50.50.50.40.30.20.30.50.4
Active lever presses in extinction session 60.10.10.3-0.1-0.2-0.3-0.3-0.2-0.2-0.2-0.6-0.6
Bone: final force0.40.60.7-0.7-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.7
Bone: final moment0.50.81.0-0.9-0.9-0.9-0.9-1.0-1.0-0.9-0.8-0.9
Food consumed during 24 hour testing period3.54.95.91.61.42.32.42.32.32.42.42.4
Glucose0.30.40.80.40.50.60.60.50.40.80.80.9
Heart weight1.93.03.4-1.8-1.5-1.7-1.8-1.8-1.8-1.7-1.7-1.7
Delay discount hyperbolic model param1.51.62.2-1.2-1.4-1.0-1.0-1.3-1.3-1.4-1.5-1.5
Intermittent access intake day 1-15 change0.10.30.8-0.6-0.9-0.7-0.5-0.4-0.4-0.3-0.3-0.3
Intermittent access intake escalation0.20.41.1-0.8-1.1-0.8-0.7-0.5-0.5-0.4-0.3-0.4
Intermittent access intake escalation 20.00.10.2-0.3-0.5-0.1-0.1-0.2-0.2-0.0-0.0-0.0
Intermitt. access day 1 inactive lever presses0.00.00.1-0.20.4-0.1-0.1-0.0-0.0-0.1-0.0-0.0
Intermitt. access day 15 inactive lever presses0.00.00.1-0.10.1-0.3-0.20.10.1-0.00.10.1
Intermitt. access escalation Index0.30.40.70.80.60.60.60.60.70.40.50.4
Intermittent access day 1 total infusions1.42.23.1-1.8-1.7-1.6-1.5-1.5-1.6-1.4-1.1-1.0
Intermittent access day 15 total infusions0.91.42.8-1.5-1.7-1.4-1.2-1.1-1.1-0.9-0.6-0.6
Intermittent access terminal intake (last 3 days)1.31.73.0-1.7-1.7-1.5-1.4-1.2-1.3-1.2-0.8-0.8
Intermittent access total infusions2.63.14.5-2.1-2.0-1.9-1.9-1.7-1.8-1.7-1.3-1.2
Intermittent access day 1 locomotion0.40.50.7-0.8-0.7-0.6-0.6-0.8-0.8-0.7-0.6-0.5
Intermittent access day 15 total locomotion0.20.31.0-0.6-1.0-0.6-0.5-0.5-0.6-0.4-0.3-0.2
Intermittent access total locomotion1.82.23.4-1.7-1.8-1.6-1.5-1.5-1.6-1.3-1.2-1.0
Intermittent access standard deviation0.10.20.4-0.0-0.10.30.40.40.40.60.60.6
Left kidney weight5.726.327.5-5.1-4.9-5.0-5.1-5.2-5.2-5.2-5.2-5.1
Right kidney weight5.223.924.4-4.9-4.7-4.9-4.9-4.9-4.9-4.9-4.9-4.9
Cocaine induced anxiety0.40.61.00.71.00.40.50.70.70.80.80.9
Post-drug Anxiety0.20.20.30.50.50.20.20.40.40.50.50.4
Baseline Anxiety0.00.00.20.1-0.20.10.1-0.1-0.1-0.1-0.1-0.4
Tail length0.20.81.0-0.9-0.8-1.0-1.0-1.0-0.9-0.8-0.9-0.9
Length with tail0.31.31.6-1.1-1.0-1.3-1.2-1.1-1.1-1.0-1.1-1.2
Length without tail0.62.02.6-1.3-1.5-1.6-1.5-1.2-1.1-1.4-1.5-1.6
Times rat made contact with spout0.10.10.1-0.2-0.2-0.1-0.1-0.2-0.2-0.3-0.4-0.4
Lifetime Intake2.42.94.3-2.1-2.0-1.8-1.8-1.7-1.7-1.6-1.3-1.2
Liver weight, left1.52.43.0-1.5-1.6-1.5-1.6-1.7-1.7-1.6-1.4-1.3
Liver weight, right1.52.63.3-1.8-1.8-1.7-1.6-1.6-1.6-1.5-1.6-1.5
Locomotor activity1.21.82.4-1.2-1.1-1.4-1.5-1.5-1.5-1.4-1.3-1.2
Locomotor testing distance0.61.01.3-0.9-0.9-1.1-1.2-1.2-1.1-0.9-0.9-0.9
Locomotor testing rearing3.87.68.4-2.7-2.9-2.9-2.9-2.8-2.8-2.7-2.7-2.6
Locomotion in novel chamber0.20.30.80.60.90.50.40.50.50.40.30.3
Locomotion in novel chamber post-restriction0.91.52.21.11.11.21.21.21.21.21.51.3
Fecal boli incidents, locomotor time 10.00.00.0-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1
Change in fecal boli incidents, locomotor task0.80.81.20.80.80.80.80.90.91.10.80.8
Time >=10cm from walls, locomotor time 10.00.10.1-0.3-0.3-0.3-0.2-0.1-0.2-0.3-0.00.0
Bouts of movement, locomotor time 11.82.12.41.21.41.41.41.51.51.41.51.5
Total resting periods, locomotor time 12.62.93.31.51.71.61.61.81.81.71.81.8
Rest time, locomotor task time 10.10.10.20.40.40.30.40.40.40.40.40.4
Distance moved, locomotor task time 10.20.30.5-0.6-0.4-0.4-0.5-0.7-0.7-0.6-0.6-0.6
Vertical activity count, locomotor time 10.00.10.20.10.10.40.30.10.10.30.10.1
Time >=10cm from walls, locomotor time 20.10.10.2-0.2-0.50.20.30.10.00.30.30.4
Bouts of movement, locomotor time 23.45.46.82.22.42.32.32.62.62.12.22.1
Total resting periods, locomotor time 22.64.66.02.12.32.12.22.42.41.92.01.9
Rest time, locomotor task time 20.00.00.10.20.20.20.20.10.10.1-0.1-0.0
Distance moved, locomotor task time 20.70.80.9-1.0-0.8-0.7-0.8-0.9-1.0-1.0-1.0-0.9
Vertical activity count, locomotor time 20.10.10.20.30.30.40.40.40.40.40.30.4
Light reinforcement 10.10.30.4-0.4-0.5-0.5-0.5-0.6-0.6-0.4-0.5-0.6
Light reinforcement 20.00.10.1-0.0-0.1-0.3-0.3-0.2-0.2-0.3-0.2-0.4
Bone: marrow area0.00.00.1-0.1-0.30.00.00.00.0-0.1-0.1-0.1
Bone: maximum diameter2.03.74.5-1.7-1.7-2.0-2.0-1.9-1.8-2.1-2.1-2.0
Bone: maximum force0.20.30.3-0.5-0.6-0.6-0.6-0.6-0.6-0.5-0.4-0.4
Bone: maximum moment0.20.40.5-0.6-0.7-0.7-0.7-0.7-0.7-0.5-0.5-0.5
Mean time between licks in bursts0.00.10.10.1-0.00.30.30.20.20.30.40.4
Mean num. licks in bursts1.01.62.30.80.61.51.51.31.11.41.41.4
Cd content in liver0.10.10.2-0.3-0.4-0.2-0.2-0.1-0.1-0.5-0.4-0.4
Co content in liver1.11.31.71.21.11.31.31.11.11.01.01.0
Cu content in liver0.20.20.5-0.00.1-0.5-0.5-0.4-0.3-0.7-0.5-0.6
Fe content in liver3.23.95.1-1.6-1.9-2.3-2.2-1.9-1.8-2.0-2.1-2.0
K content in liver0.10.10.20.50.50.1-0.0-0.1-0.0-0.2-0.1-0.2
Mg content in liver0.20.20.40.00.0-0.3-0.4-0.6-0.6-0.6-0.5-0.5
Mn content in liver0.91.02.0-0.7-0.8-0.6-0.7-1.3-1.4-1.1-1.0-1.0
Na content in liver0.00.00.10.00.1-0.2-0.2-0.3-0.2-0.2-0.0-0.2
Rb content in liver0.20.20.4-0.3-0.3-0.5-0.5-0.4-0.4-0.7-0.6-0.6
Se content in liver1.92.33.1-0.9-1.1-1.5-1.6-1.8-1.7-1.6-1.6-1.6
Sr content in liver0.00.00.00.10.10.10.1-0.0-0.00.10.10.1
Zn content in liver0.91.01.7-0.7-0.9-0.9-0.9-0.9-0.9-1.3-1.0-1.2
Bone: minimum diameter0.20.40.6-0.7-0.8-0.7-0.7-0.6-0.6-0.6-0.5-0.6
Time in familiar zone, hab. session 10.20.20.4-0.6-0.7-0.5-0.4-0.4-0.4-0.4-0.3-0.3
Time in novel zone, hab. session 10.70.70.8-0.9-0.9-0.8-0.8-0.8-0.9-0.7-0.7-0.7
Total zone transitions, hab. session 10.30.50.7-0.8-0.8-0.7-0.7-0.6-0.6-0.7-0.6-0.6
Total locomotion distance, hab. session 10.30.50.70.30.30.70.70.70.80.80.80.8
Locomotion velocity, hab. session 11.01.51.80.80.81.21.31.31.31.31.31.3
Time in familiar zone, hab. session 20.30.30.8-0.8-0.9-0.7-0.6-0.3-0.2-0.2-0.3-0.4
Time in novel zone, hab. session 20.00.00.0-0.00.10.10.1-0.0-0.1-0.10.10.2
Total zone transitions, hab. session 20.40.50.8-0.4-0.6-0.6-0.7-0.8-0.8-0.7-0.9-0.9
Total locomotion distance, hab. session 20.50.70.80.80.80.90.90.80.80.80.70.7
Locomotion velocity, hab. session 20.30.40.60.70.60.80.70.60.60.70.50.5
Novel to familiar place preference ratio1.61.72.4-1.5-1.6-1.3-1.2-1.2-1.2-1.4-1.2-1.2
Novelty place preference1.51.62.3-1.5-1.5-1.2-1.1-1.1-1.2-1.3-1.1-1.1
Time in novel zone, NPP test1.92.03.2-1.8-1.8-1.4-1.3-1.3-1.3-1.4-1.2-1.1
Total zone transitions, NPP test0.10.10.20.10.1-0.3-0.4-0.3-0.2-0.4-0.5-0.5
Total locomotion distance, NPP test0.20.20.3-0.6-0.6-0.5-0.5-0.3-0.3-0.5-0.6-0.6
Locomotion velocity, NPP test0.10.20.4-0.2-0.3-0.4-0.3-0.2-0.1-0.5-0.6-0.6
Intraocular pressure0.00.10.10.0-0.3-0.3-0.2-0.1-0.10.0-0.3-0.3
Delta distance traveled before/after self-admin2.22.32.81.51.71.51.51.41.41.41.61.6
Delta ambulatory time before/after self-admin0.50.70.90.71.00.80.80.70.70.71.01.0
Parametrial fat weight0.00.10.2-0.4-0.1-0.2-0.3-0.4-0.4-0.4-0.3-0.4
Pavlov. Cond. lever latency0.40.50.90.30.30.60.70.80.70.90.90.9
Pavlov. Cond. magazine entry latency0.20.20.4-0.3-0.5-0.5-0.4-0.3-0.2-0.4-0.7-0.7
Pavlov. Cond. change in total contacts0.30.30.50.70.50.70.70.60.60.50.30.3
Pavlov. Cond. index score0.30.30.7-0.1-0.3-0.5-0.5-0.5-0.5-0.7-0.9-0.9
Pavlov. Cond. latency score0.10.10.20.20.1-0.1-0.2-0.2-0.1-0.3-0.5-0.5
Pavlov. Cond. lever contacts0.30.40.7-0.3-0.3-0.5-0.5-0.6-0.5-0.8-0.8-0.8
Pavlov. Cond. magazine entry number0.10.10.30.10.20.20.20.10.10.20.60.5
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.6-0.5-0.3-0.3-0.5-0.6-0.4-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.1-0.3-0.5-0.5-0.6-0.6-0.7-0.9-0.9
Pavlov. Cond. response bias1.01.32.1-0.8-0.9-1.1-1.1-1.0-1.0-1.2-1.4-1.5
Pavlov. Cond. lever latency0.00.00.10.20.10.20.20.20.20.20.30.3
Pavlov. Cond. magazine entry latency0.91.13.1-1.6-1.8-1.0-0.8-0.6-0.7-0.8-0.9-0.9
Pavlov. Cond. change in total contacts0.00.00.0-0.2-0.1-0.00.10.20.10.10.00.0
Pavlov. Cond. index score0.20.30.7-0.8-0.9-0.5-0.4-0.2-0.2-0.3-0.4-0.4
Pavlov. Cond. latency score0.10.10.5-0.7-0.7-0.3-0.2-0.0-0.1-0.2-0.2-0.2
Pavlov. Cond. lever contacts0.10.20.3-0.5-0.4-0.5-0.4-0.3-0.3-0.4-0.6-0.5
Pavlov. Cond. magazine entry number0.20.20.90.90.90.30.1-0.2-0.1-0.00.10.1
Pavlov. Cond. intertrial magazine entries0.20.41.31.11.10.50.30.20.20.30.30.3
Pavlov. Cond. lever-magazine prob. diff.0.30.41.0-1.0-1.0-0.6-0.5-0.4-0.4-0.5-0.6-0.5
Pavlov. Cond. response bias0.10.20.4-0.6-0.6-0.4-0.3-0.2-0.2-0.3-0.5-0.4
Time in closed arm before self-admin1.01.21.4-1.2-1.1-1.1-1.1-1.0-1.0-1.1-1.1-1.1
Time in closed arm after self-admin0.60.71.00.60.70.50.61.01.00.81.01.0
Time in open arm before self-admin1.01.11.21.01.11.11.11.00.91.11.11.1
Time in open arm after self-admin0.30.30.70.70.70.90.70.30.30.50.50.4
Bone: periosteal estimation0.30.60.7-0.8-0.8-0.8-0.8-0.7-0.7-0.9-0.8-0.8
Bone: periosteal perimeter0.20.30.5-0.4-0.5-0.7-0.6-0.5-0.5-0.7-0.7-0.6
Bone: post-yield work0.71.01.31.10.90.80.81.01.11.00.91.0
Progressive ratio test 1 active lever presses2.12.63.3-1.8-1.7-1.5-1.6-1.8-1.8-1.7-1.4-1.3
Progressive ratio test 1 breakpoint1.92.33.0-1.7-1.6-1.4-1.5-1.7-1.7-1.6-1.3-1.2
Progressive ratio test 1 inactive lever presses1.42.03.0-1.7-1.5-1.5-1.5-1.3-1.4-1.3-1.2-1.2
Progressive ratio test 2 active lever presses2.02.43.2-1.7-1.8-1.7-1.6-1.5-1.5-1.4-1.3-1.2
Progressive ratio test 2 breakpoint2.32.63.5-1.8-1.9-1.8-1.7-1.6-1.6-1.5-1.4-1.3
Progressive ratio test 2 inactive lever presses0.10.20.4-0.5-0.6-0.6-0.5-0.3-0.3-0.3-0.2-0.1
Incentive Sensitization - Responses1.21.72.4-1.3-1.5-1.6-1.4-1.1-1.1-1.2-1.3-1.2
Incentive Sensitization - Breakpoint1.21.52.2-1.2-1.4-1.5-1.4-1.0-1.0-1.1-1.2-1.2
Sum of active levers in priming session hrs 5-60.50.50.80.80.80.70.70.50.50.50.90.9
Progressive ratio1.21.92.41.41.11.21.31.51.51.61.41.4
Food seeking constrained by brief footshock4.95.97.32.32.32.72.62.32.22.52.42.5
Seeking ratio, punishment vs. effort0.40.60.90.70.91.00.90.60.50.60.70.8
Retroperitoneal fat weight0.00.10.20.30.4-0.3-0.3-0.1-0.0-0.3-0.3-0.3
Reaction time number correct3.77.18.5-2.9-2.6-2.8-2.8-2.8-2.9-2.5-2.1-2.2
Reaction time mean minus median0.00.00.1-0.2-0.4-0.00.00.10.1-0.1-0.1-0.1
Reaction time mean minus median AUC0.20.60.9-0.6-0.8-0.8-0.7-0.6-0.5-0.9-0.8-0.8
Reaction time num false alarms4.76.77.5-2.7-2.7-2.6-2.6-2.4-2.4-2.6-2.6-2.6
Reaction time num false alarms AUC3.45.35.7-2.4-2.3-2.3-2.3-2.2-2.2-2.4-2.3-2.3
Reaction time trials correct on left3.77.18.5-2.9-2.6-2.8-2.8-2.8-2.9-2.5-2.1-2.2
Reaction time trials on left3.77.08.5-2.9-2.6-2.8-2.8-2.8-2.9-2.5-2.1-2.2
Reaction time mean0.30.50.90.20.40.90.91.00.90.80.50.6
Reaction time mean AUC0.20.40.70.20.40.70.80.80.80.60.40.4
Median of all reaction times0.60.81.30.40.61.11.11.11.01.10.70.8
Reaction time omissions0.10.10.2-0.1-0.1-0.2-0.3-0.3-0.4-0.4-0.4-0.3
Reaction time false alarm rate0.20.20.5-0.4-0.5-0.4-0.4-0.3-0.2-0.5-0.7-0.6
Reaction time premature initiation rate0.30.40.70.60.50.80.80.70.70.60.60.6
Reaction time premature initiations0.30.50.6-0.8-0.7-0.6-0.7-0.8-0.8-0.8-0.5-0.6
Std. dev. reaction times0.00.10.10.0-0.00.30.30.40.40.20.10.2
Reaction time trials completed3.77.08.5-2.9-2.6-2.8-2.8-2.8-2.9-2.5-2.1-2.2
Reaction time trials AUC4.58.710.3-3.2-2.9-3.1-3.1-3.1-3.2-2.8-2.4-2.5
Run reversals in cocaine runway, females0.50.51.60.91.30.40.40.70.70.60.40.4
Run reversals in cocaine runway, males0.50.50.7-0.4-0.6-0.6-0.7-0.8-0.8-0.7-0.7-0.7
Latency to leave start box in cocaine runway0.20.20.5-0.5-0.6-0.7-0.6-0.3-0.3-0.4-0.2-0.2
Latency to leave start box in cocaine runway, F0.60.70.9-0.8-0.9-0.9-0.9-0.9-0.8-0.9-0.6-0.7
Latency to leave start box in cocaine runway, M0.00.00.1-0.0-0.1-0.2-0.10.20.30.10.10.2
Std. dev. time between licks in bursts0.00.10.1-0.2-0.3-0.2-0.2-0.2-0.2-0.3-0.2-0.2
Total sessions with >9 infusions3.44.15.1-2.2-2.3-2.0-2.0-2.1-2.2-2.0-1.8-1.6
Short access day 1 total inactive lever presses0.50.60.8-0.8-0.9-0.9-0.9-0.7-0.6-0.7-0.7-0.8
Short access day 10 total inactive lever presses0.51.32.01.11.41.11.11.21.31.10.90.9
Short access day 1 total infusions1.72.22.9-1.7-1.7-1.5-1.5-1.6-1.6-1.5-1.3-1.2
Short access day 10 total infusions3.54.46.0-2.4-2.2-2.1-2.1-2.2-2.3-2.1-1.7-1.6
Short access total infusions1.92.53.5-1.9-1.7-1.6-1.6-1.7-1.7-1.5-1.2-1.2
Short access day 1 locomotion3.03.85.4-2.0-2.3-2.0-2.0-2.0-2.1-1.8-1.7-1.6
Short access day 10 total locomotion0.10.10.2-0.2-0.2-0.1-0.1-0.4-0.4-0.3-0.5-0.4
Short access total locomotion0.91.01.6-1.2-1.1-0.8-0.9-1.2-1.3-1.0-0.9-0.7
One hour access (0.3 mA shock)0.10.10.4-0.5-0.6-0.5-0.4-0.2-0.2-0.2-0.1-0.0
Compulsive drug intake0.40.50.8-0.5-0.5-0.5-0.6-0.7-0.6-0.8-0.9-0.9
One hour access (shock baseline)0.91.42.7-1.4-1.6-1.4-1.3-1.1-1.1-1.0-0.8-0.8
Social response proportion1.82.12.5-1.5-1.2-1.5-1.5-1.4-1.4-1.6-1.5-1.5
Social responses1.01.31.8-1.0-0.8-1.2-1.2-1.1-1.1-1.3-1.2-1.1
Social time3.14.24.92.22.22.02.12.22.21.91.91.9
Soleus weight0.10.30.8-0.3-0.4-0.9-0.8-0.3-0.2-0.8-0.5-0.6
Bone: stiffness0.71.11.5-1.0-1.1-1.2-1.2-1.0-0.9-1.0-1.0-1.1
Tibialis anterior weight3.110.612.8-3.1-3.0-3.5-3.4-3.1-3.0-3.6-3.2-3.3
Time to tail flick, vehicle, before self-admin2.52.63.6-1.6-1.4-1.4-1.5-1.8-1.9-1.7-1.6-1.5
Time to tail flick, vehicle, after self-admin0.10.10.2-0.3-0.3-0.5-0.4-0.00.0-0.10.0-0.0
Time to tail flick, test, before self-admin0.50.51.10.60.71.00.90.50.50.80.50.5
Time to tail flick, test, after self-admin0.30.30.60.30.40.50.50.40.40.50.70.8
Delta time to tail flick, vehicle, before/after SA0.10.10.20.1-0.00.00.10.40.40.30.30.2
Delta time to tail flick, test, before/after SA0.70.81.1-1.0-0.8-1.1-1.0-0.8-0.8-1.0-0.6-0.6
Tibia length0.20.71.4-0.7-0.4-0.7-0.8-0.9-0.9-0.6-1.2-1.0
Ambulatory time before self-admin0.00.00.10.10.10.0-0.00.10.10.0-0.2-0.2
Ambulatory time after self-admin0.50.61.10.91.10.80.80.70.70.70.70.7
Bone: tissue strength0.70.71.01.00.80.90.90.70.70.80.70.8
Total heroin consumption0.00.00.10.30.20.20.10.10.10.10.10.1
Bone: trabecular number0.00.00.20.50.20.10.10.10.10.0-0.00.0
Bone: trabecular spacing0.00.00.1-0.3-0.3-0.1-0.1-0.1-0.1-0.2-0.1-0.1
Bone: trabecular thickness1.51.92.2-1.2-1.2-1.4-1.4-1.4-1.4-1.4-1.5-1.5
Bone: trabecular tissue density0.50.71.2-1.1-1.0-0.8-0.8-0.7-0.7-0.5-1.0-0.9
Water consumed over 24 hours0.00.00.1-0.20.00.30.2-0.1-0.20.1-0.1-0.1
Number of responses in last shaping day3.53.86.5-2.2-2.5-1.9-1.9-1.8-1.8-1.8-1.7-1.7