Hub : Genes

Tnrc6b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Tnrc6b 0.06 0.04 5.8e-04 0.01 0.02 0.03 0.02 4.8e-02 2.4e-03 5.7e-04 2.2e-03
2 OFC gene expression Tnrc6b 0.17 0.1 2.6e-03 0.03 0.07 0.01 0.03 6.8e-02 9.2e-03 1.6e-01 5.9e-02
3 IC gene expression Tnrc6b 0.29 0.15 4.2e-08 0.14 0.18 0.17 0.18 1.6e-06 3.3e-08 1.0e-07 4.0e-08
4 PL gene expression Tnrc6b 0.08 0.04 1.8e-10 0.1 0.1 0.1 0.1 2.5e-11 6.2e-11 1.5e-10 4.3e-11
5 Liver gene expression Tnrc6b 0.09 0.05 1.3e-08 0.06 0.07 0.06 0.06 9.6e-08 3.5e-08 1.4e-07 2.0e-07
6 NAcc gene expression Tnrc6b 0.04 0.03 1.5e-06 0.04 0.04 0.04 0.03 1.6e-06 1.7e-06 2.7e-06 5.1e-06
7 Brain gene expression Tnrc6b 0.22 0.1 0.0e+00 0.17 0.2 0.2 0.2 1.5e-15 1.7e-18 4.8e-18 6.7e-18
8 BLA gene expression Tnrc6b 0.22 0.11 7.1e-09 0.1 0.14 0.14 0.12 4.4e-06 6.8e-08 9.3e-08 5.5e-07
9 BLA alternative TSS XM_039078367.2 0.07 0.05 8.7e-03 0.04 0.01 0.02 0.03 5.1e-03 9.4e-02 3.4e-02 1.6e-02
10 pVTA gene expression Tnrc6b 0.06 0.05 4.0e-03 0.03 0.02 0.01 0.02 2.4e-03 1.1e-02 5.8e-02 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.30.64.0-2.0-0.3-0.5-0.6-0.6-0.4-0.4-0.6-0.0-0.1
Area under the delay curve0.91.12.01.3-0.3-0.9-0.8-0.3-0.7-1.4-1.41.1-1.4
BMI with tail0.20.72.6-1.6-1.2-0.6-0.5-1.1-0.40.20.4-0.50.3
BMI without tail0.10.20.5-0.1-0.30.1-0.1-0.6-0.10.40.3-0.60.7
Body weight0.41.75.7-2.4-2.0-1.4-1.1-1.4-1.1-0.6-0.10.6-0.7
Weight adjusted by age0.40.61.40.40.90.80.91.20.90.60.7-0.40.5
Bone surface0.51.04.6-2.1-0.4-0.9-0.8-0.2-0.5-1.0-1.00.8-0.9
Bone volume0.51.06.6-2.6-0.5-0.8-0.7-0.4-0.5-0.7-0.70.4-0.5
Breakpoint value in progressive ratio session0.30.40.7-0.6-0.7-0.7-0.8-0.8-0.8-0.5-0.60.2-0.3
Number of licking bursts0.30.53.31.80.80.40.50.80.4-0.1-0.20.3-0.3
Context. condit. distance diff. score1.11.44.0-1.9-0.30.70.80.30.81.42.0-0.91.1
Locomotion velocity, session 11.01.12.90.5-0.5-0.9-0.7-0.1-0.9-1.3-1.21.7-1.5
Locomotion distance, session 10.81.13.61.90.6-0.3-0.30.6-0.2-1.1-1.31.3-1.3
Locomotion velocity, session 20.40.40.6-0.6-0.8-0.7-0.7-0.6-0.8-0.7-0.60.7-0.6
Locomotion distance, session 21.72.45.41.8-0.4-1.3-1.4-0.8-1.3-2.0-2.31.6-1.7
Locomotion velocity, session 31.31.52.7-1.11.01.01.41.61.51.21.6-0.70.7
Locomotion distance, session 32.22.45.61.32.01.61.82.41.91.11.3-0.60.5
Stereotopy head waving bouts, day 31.51.82.5-0.5-1.6-1.5-1.4-1.4-1.5-1.3-1.21.2-1.2
Stereotopy head waving duration, day 32.32.84.8-2.1-2.2-1.8-1.7-1.8-1.9-1.3-1.01.2-1.1
Locomotion velocity, session 70.20.20.7-0.80.10.10.30.50.50.30.6-0.20.1
Locomotion distance, session 70.40.51.00.1-0.5-0.7-0.6-0.2-0.6-0.9-0.71.0-1.0
Stereotopy head waving bouts, day 70.70.82.6-1.60.10.40.60.70.71.01.3-0.70.7
Stereotopy head waving duration, day 71.31.65.7-2.40.10.70.80.50.81.41.7-1.31.3
Locomotion velocity, session 80.91.02.0-0.3-1.4-1.2-1.1-0.9-1.0-1.0-0.61.1-1.1
Locomotion distance, session 80.30.41.0-0.50.10.50.60.30.60.81.0-0.70.7
Degree of sensitization distance2.72.76.0-1.3-2.3-1.7-1.9-2.4-2.0-1.2-1.20.8-0.7
Degree of sensitization stereotypy0.80.82.1-1.20.20.60.70.70.91.11.4-0.90.8
Conditioned locomotion0.00.00.10.2-0.20.00.1-0.00.30.20.4-0.20.0
Cocaine response after cond. corrected0.40.41.2-1.1-0.6-0.7-0.6-0.5-0.6-0.6-0.50.5-0.7
Cocaine response after cond. not corrected0.30.32.3-1.5-0.4-0.4-0.3-0.4-0.3-0.2-0.20.0-0.1
Cocaine response before conditioning0.50.61.2-0.30.80.80.80.50.70.90.7-1.01.1
Saline control response1.11.52.1-0.51.11.21.21.01.41.41.3-1.51.2
Bone: connectivity density0.40.74.3-2.1-0.4-0.6-0.6-0.5-0.5-0.6-0.60.3-0.4
Bone: cortical apparent density1.72.33.91.11.91.61.72.01.81.31.3-1.01.0
Bone: cortical area2.13.24.9-2.2-2.1-2.0-1.9-1.9-1.8-1.6-1.41.4-1.4
Bone: cortical porosity1.01.18.3-2.9-0.8-0.5-0.5-1.0-0.50.10.0-0.40.4
Bone: cortical porosity1.92.110.8-3.3-1.6-1.3-1.2-1.6-1.2-0.6-0.50.3-0.3
Bone: cortical thickness0.71.11.5-0.7-1.2-1.2-1.2-1.2-1.1-1.1-1.00.9-1.0
Bone: cortical thickness2.22.63.31.5-1.5-1.6-1.7-1.4-1.5-1.8-1.71.7-1.8
Bone: cortical tissue density1.62.23.91.21.81.61.72.01.71.31.3-1.00.9
Condit. Reinf. active minus inactive responses0.10.20.40.70.1-0.2-0.20.2-0.2-0.4-0.50.5-0.5
Condit. Reinf. active-inactive response ratio0.10.10.4-0.10.30.30.40.60.40.30.5-0.00.0
Condit. Reinf. active responses0.10.20.70.10.80.50.30.50.30.2-0.1-0.40.4
Condit. Reinf. inactive responses0.50.61.6-0.11.30.90.70.60.70.60.2-1.01.1
Incentive salience index mean0.10.10.20.30.2-0.1-0.10.2-0.2-0.3-0.50.3-0.3
Condit. Reinf. lever presses0.10.10.5-0.70.30.00.00.1-0.0-0.1-0.3-0.10.1
Condit. Reinf. active minus inactive responses1.62.13.70.5-0.9-1.4-1.3-0.7-1.4-1.8-1.71.9-1.8
Condit. Reinf. active-inactive response ratio1.92.23.2-0.1-1.3-1.6-1.5-1.1-1.5-1.8-1.71.7-1.7
Condit. Reinf. active responses1.21.73.50.3-1.0-1.3-1.1-0.5-1.2-1.6-1.41.9-1.7
Condit. Reinf. inactive responses0.30.41.40.1-0.5-0.7-0.40.0-0.5-0.8-0.51.2-1.1
Condit. Reinf. lever presses0.10.10.3-0.6-0.0-0.3-0.3-0.2-0.3-0.4-0.60.2-0.3
Condit. Reinf. lever reinforcers received1.01.42.5-0.1-1.0-1.3-1.1-0.6-1.2-1.5-1.31.6-1.5
Conditioned reinforcement - actives0.50.81.71.3-0.5-0.6-0.7-0.4-0.7-1.1-0.91.3-1.1
Conditioned reinforcement - inactives1.82.65.10.9-1.1-1.5-1.7-1.6-1.7-2.0-2.31.6-1.5
Conditioned locomotion2.22.93.8-0.2-1.9-1.7-1.9-1.9-1.9-1.7-1.71.7-1.4
Patch foraging indifference point 0 sec0.20.42.3-1.5-0.2-0.2-0.5-0.7-0.5-0.3-0.6-0.20.2
Patch foraging indifference point AUC1.11.66.62.60.2-0.4-0.40.5-0.5-1.3-1.31.8-1.6
Delay disc. indifference point, 0s delay1.41.55.0-2.2-1.4-1.2-1.3-1.5-1.1-0.7-0.70.1-0.6
Delay disc. indifference point, 16s delay0.60.72.71.70.2-0.4-0.30.1-0.2-1.0-1.20.8-0.9
Delay disc. indifference point, 2s delay0.80.91.90.6-0.6-0.9-0.9-0.6-0.8-1.2-1.10.9-1.4
Delay disc. indifference point, 24s delay2.22.47.22.7-0.4-1.1-0.90.1-0.8-1.8-1.61.9-2.1
Delay disc. indifference point, 4s delay1.01.01.70.0-0.7-1.1-1.1-0.7-1.0-1.3-1.31.1-1.1
Delay disc. indifference point, 8s delay0.60.73.41.90.1-0.4-0.4-0.0-0.3-0.9-1.00.7-0.9
Indifference point function ln k0.91.65.6-2.40.00.70.80.20.81.41.6-1.51.4
Indifference point function log k0.91.65.6-2.40.00.70.80.20.81.41.6-1.51.4
Patch foraging total patch changes 0 sec0.20.31.5-1.2-0.1-0.2-0.5-0.7-0.4-0.2-0.6-0.30.2
Patch foraging total patch changes 12 sec0.40.50.8-0.4-0.4-0.7-0.8-0.4-0.7-0.8-0.90.7-0.7
Patch foraging total patch changes 18 sec1.82.74.70.1-1.2-1.6-1.9-1.5-1.9-2.0-2.21.7-1.4
Patch foraging total patch changes 24 sec0.10.20.6-0.2-0.0-0.4-0.6-0.2-0.3-0.7-0.80.5-0.6
Patch foraging total patch changes 6 sec1.92.85.5-0.1-1.1-1.7-1.8-1.5-1.8-2.1-2.31.5-1.8
Patch foraging time to switch 0 sec0.50.97.0-2.6-0.6-0.4-0.5-0.9-0.40.1-0.1-0.60.5
Patch foraging water rate 0 sec0.10.20.30.4-0.2-0.3-0.5-0.4-0.5-0.5-0.60.4-0.3
Patch foraging water rate 12 sec0.30.71.01.00.90.90.70.60.60.90.7-1.01.0
Patch foraging water rate 18 sec0.10.10.30.40.3-0.1-0.0-0.0-0.1-0.4-0.6-0.0-0.2
Patch foraging water rate 24 sec0.20.31.9-1.4-0.1-0.00.2-0.10.10.30.3-0.50.3
Patch foraging water rate 6 sec1.62.44.00.12.01.71.71.81.71.51.3-1.41.4
Seeking ratio, delayed vs. immediate footshock0.20.30.91.00.60.40.30.30.40.40.1-0.70.5
Distance traveled before self-admin0.10.10.50.1-0.3-0.1-0.4-0.7-0.4-0.3-0.50.2-0.0
Distance traveled after self-admin1.82.33.9-0.3-1.3-1.6-1.6-1.7-1.6-1.7-2.01.1-1.5
Extensor digitorum longus weight0.20.81.8-0.80.80.90.80.10.80.90.6-1.41.2
Bone: elastic displacement0.00.00.2-0.40.10.00.20.20.20.10.2-0.0-0.1
Bone: elastic work2.53.28.5-2.9-2.2-1.9-1.8-2.0-1.6-1.4-1.21.0-1.2
Bone: endosteal estimation1.12.55.7-2.4-1.7-1.7-1.7-1.5-1.6-1.4-1.31.1-1.0
Bone: endosteal perimeter0.91.98.3-2.9-1.6-1.4-1.2-1.2-1.2-0.8-0.60.6-0.7
Epididymis fat weight0.62.113.3-3.6-1.9-1.2-0.7-1.1-0.7-0.10.60.4-0.4
Delta time in closed arm before/after self-admin0.40.41.00.6-0.6-0.5-0.5-0.3-0.6-0.7-0.51.0-0.8
Delta time in open arm before/after self-admin0.00.00.20.40.30.20.20.10.20.1-0.1-0.10.1
Diff in mean of infusions in LGA sessions0.91.12.30.2-1.0-1.1-1.0-0.6-1.0-1.3-1.01.5-1.3
Delay discount exponential model param0.91.02.1-1.40.20.80.70.20.61.31.4-1.11.4
Extinction: sum of active levers before priming2.22.43.5-0.8-1.7-1.9-1.7-1.5-1.7-1.6-1.41.3-1.6
Active lever presses in extinction session 60.40.40.6-0.8-0.8-0.7-0.7-0.7-0.7-0.5-0.40.3-0.3
Bone: final force3.35.37.5-2.7-2.6-2.6-2.5-2.3-2.2-2.2-2.01.8-1.9
Bone: final moment3.76.07.7-2.7-2.8-2.7-2.6-2.5-2.4-2.4-2.12.0-2.0
Food consumed during 24 hour testing period1.82.54.10.0-2.0-1.8-1.7-1.8-1.8-1.6-1.31.4-1.5
Glucose0.40.75.0-2.2-0.3-0.2-0.5-0.7-0.30.1-0.0-0.60.7
Heart weight3.04.68.9-3.0-2.8-2.3-2.2-2.7-2.2-1.6-1.31.2-1.4
Delay discount hyperbolic model param0.80.91.7-1.30.20.80.70.20.61.21.3-1.01.3
Intermittent access intake day 1-15 change0.40.71.60.40.81.10.80.50.80.90.7-0.91.3
Intermittent access intake escalation0.50.91.60.51.11.21.00.71.01.00.8-1.01.2
Intermittent access intake escalation 20.70.81.90.00.81.10.80.40.80.90.7-1.01.4
Intermitt. access day 1 inactive lever presses0.41.32.6-1.4-1.3-1.1-1.2-1.6-1.2-0.9-1.00.7-0.6
Intermitt. access day 15 inactive lever presses0.20.51.10.4-0.5-0.6-0.8-0.9-0.8-0.8-1.00.6-0.2
Intermitt. access escalation Index0.30.40.7-0.20.80.70.60.60.60.60.5-0.70.5
Intermittent access day 1 total infusions2.03.34.60.5-1.7-1.8-1.9-1.6-1.9-2.0-2.02.1-1.9
Intermittent access day 15 total infusions0.20.31.71.3-0.0-0.1-0.3-0.2-0.3-0.5-0.70.6-0.3
Intermittent access terminal intake (last 3 days)0.30.31.91.4-0.10.1-0.3-0.2-0.3-0.5-0.60.8-0.2
Intermittent access total infusions2.22.63.91.0-1.4-1.4-1.7-1.5-1.8-1.8-1.92.0-1.6
Intermittent access day 1 locomotion1.72.23.3-0.3-1.5-1.4-1.7-1.8-1.7-1.5-1.71.3-1.2
Intermittent access day 15 total locomotion1.12.02.7-0.0-1.5-1.4-1.7-1.6-1.6-1.5-1.51.4-1.1
Intermittent access total locomotion2.83.44.6-0.1-1.9-1.8-2.1-2.0-2.1-2.0-2.01.9-1.6
Intermittent access standard deviation0.61.33.9-0.9-1.5-0.9-1.2-2.0-1.2-0.8-1.00.6-0.0
Left kidney weight2.310.723.4-4.7-4.8-3.8-3.0-3.0-2.9-2.2-0.82.7-2.8
Right kidney weight3.013.631.0-5.1-5.6-4.3-3.4-3.9-3.4-2.3-1.02.5-3.0
Cocaine induced anxiety0.91.32.5-1.2-1.6-1.4-1.1-1.1-1.1-1.0-0.60.9-1.2
Post-drug Anxiety0.00.10.20.10.00.10.30.30.30.20.4-0.1-0.1
Baseline Anxiety1.82.15.92.41.81.61.41.61.41.00.7-0.71.0
Tail length0.20.61.00.31.01.00.90.80.70.80.6-0.60.9
Length with tail0.10.53.7-1.9-0.5-0.4-0.10.1-0.1-0.10.30.4-0.4
Length without tail1.13.49.3-3.1-2.4-2.0-1.6-1.7-1.6-1.4-0.81.5-1.5
Times rat made contact with spout1.01.14.02.0-0.7-0.7-0.7-0.5-0.7-1.0-0.91.3-1.3
Lifetime Intake3.84.75.90.6-2.1-2.1-2.3-2.0-2.4-2.4-2.42.4-2.2
Liver weight, left0.81.32.71.20.71.01.31.41.31.21.6-0.50.6
Liver weight, right2.23.99.1-0.91.11.92.11.72.02.53.0-1.71.9
Locomotor activity0.30.41.3-1.2-1.0-0.6-0.5-0.7-0.6-0.3-0.00.4-0.3
Locomotor testing distance0.00.00.10.00.20.30.20.20.10.20.1-0.10.3
Locomotor testing rearing0.10.20.7-0.8-0.7-0.3-0.3-0.4-0.40.00.20.4-0.0
Locomotion in novel chamber3.44.45.70.42.42.42.31.92.32.11.9-2.22.2
Locomotion in novel chamber post-restriction0.50.71.20.21.11.00.90.90.90.90.7-0.71.0
Fecal boli incidents, locomotor time 11.42.03.50.9-1.0-1.3-1.4-1.2-1.6-1.7-1.91.6-1.3
Change in fecal boli incidents, locomotor task0.80.82.41.50.60.50.91.50.70.40.90.4-0.4
Time >=10cm from walls, locomotor time 10.80.81.4-0.4-1.1-0.9-0.9-0.9-1.0-0.9-0.81.2-0.7
Bouts of movement, locomotor time 10.40.41.0-0.9-0.8-0.8-0.5-0.2-0.4-0.5-0.10.6-1.0
Total resting periods, locomotor time 10.60.71.2-0.8-1.0-1.0-0.8-0.5-0.8-0.8-0.50.9-1.1
Rest time, locomotor task time 10.91.21.8-0.3-1.3-1.2-1.1-1.1-1.2-1.0-0.91.3-1.1
Distance moved, locomotor task time 10.71.01.5-0.60.70.90.90.71.01.21.2-1.21.1
Vertical activity count, locomotor time 10.10.10.5-0.70.10.10.0-0.10.10.20.1-0.70.5
Time >=10cm from walls, locomotor time 20.10.20.4-0.7-0.3-0.4-0.3-0.4-0.5-0.4-0.40.3-0.2
Bouts of movement, locomotor time 20.10.10.9-0.9-0.10.00.10.10.20.40.5-0.30.2
Total resting periods, locomotor time 20.10.10.3-0.5-0.4-0.4-0.3-0.2-0.3-0.1-0.00.2-0.3
Rest time, locomotor task time 20.40.51.71.3-0.3-0.4-0.4-0.1-0.7-0.8-0.71.1-0.8
Distance moved, locomotor task time 20.70.92.9-1.70.30.60.70.30.91.01.1-1.00.9
Vertical activity count, locomotor time 20.20.21.3-1.2-0.4-0.4-0.3-0.5-0.2-0.1-0.1-0.2-0.0
Light reinforcement 10.00.10.2-0.5-0.1-0.2-0.3-0.2-0.3-0.3-0.50.3-0.2
Light reinforcement 20.71.02.0-1.40.30.80.90.50.91.31.4-1.01.1
Bone: marrow area1.32.85.7-2.4-1.8-1.8-1.8-1.6-1.7-1.5-1.41.2-1.1
Bone: maximum diameter3.36.110.6-3.3-3.1-2.8-2.5-2.5-2.5-2.1-1.71.9-1.9
Bone: maximum force4.98.711.2-2.8-3.4-3.3-3.2-3.0-3.0-3.0-2.72.6-2.6
Bone: maximum moment5.49.412.0-2.8-3.5-3.4-3.3-3.1-3.1-3.1-2.82.8-2.7
Mean time between licks in bursts0.30.61.10.60.90.90.80.40.70.80.5-1.01.0
Mean num. licks in bursts0.20.31.0-0.2-1.0-0.6-0.6-0.7-0.5-0.3-0.00.5-0.5
Cd content in liver0.80.95.52.3-0.3-0.3-0.10.3-0.2-0.6-0.21.2-1.2
Co content in liver1.21.45.02.2-0.8-0.8-1.0-1.0-1.0-1.1-1.21.0-1.1
Cu content in liver0.20.21.20.11.10.40.20.30.2-0.1-0.7-0.50.4
Fe content in liver3.03.616.8-4.1-1.8-1.7-1.8-1.9-1.5-1.2-1.20.6-0.7
K content in liver0.60.61.6-1.31.00.70.60.70.60.60.4-0.70.6
Mg content in liver0.20.22.1-1.50.2-0.0-0.1-0.1-0.2-0.1-0.4-0.10.2
Mn content in liver0.50.61.30.30.90.81.01.10.90.70.8-0.30.4
Na content in liver0.20.20.5-0.60.60.50.30.10.10.3-0.0-0.60.7
Rb content in liver1.82.02.7-0.7-1.2-1.5-1.6-1.2-1.4-1.6-1.61.4-1.7
Se content in liver1.21.41.8-0.71.31.31.31.31.31.21.2-1.11.0
Sr content in liver2.72.37.52.71.71.61.31.21.31.20.9-1.31.3
Zn content in liver0.10.10.3-0.30.40.10.20.50.20.00.10.1-0.2
Bone: minimum diameter1.22.24.5-2.1-1.6-1.6-1.5-1.3-1.6-1.3-1.21.2-1.0
Time in familiar zone, hab. session 11.11.02.2-0.0-0.7-1.1-0.9-0.3-0.8-1.3-1.11.4-1.5
Time in novel zone, hab. session 10.70.71.90.00.10.80.5-0.20.41.11.0-1.21.4
Total zone transitions, hab. session 12.02.76.11.92.41.71.82.51.81.00.8-0.60.6
Total locomotion distance, hab. session 12.02.86.61.12.41.72.02.61.91.21.1-0.80.8
Locomotion velocity, hab. session 11.21.74.60.82.01.31.52.11.50.80.6-0.50.5
Time in familiar zone, hab. session 21.41.52.0-0.21.21.31.41.41.41.31.4-1.11.1
Time in novel zone, hab. session 21.31.31.70.6-1.1-1.2-1.2-1.3-1.3-1.2-1.31.0-1.0
Total zone transitions, hab. session 21.01.22.61.1-0.2-0.9-0.9-0.2-0.9-1.5-1.61.4-1.4
Total locomotion distance, hab. session 20.40.51.40.8-0.0-0.5-0.5-0.3-0.6-0.9-1.20.7-0.7
Locomotion velocity, hab. session 20.40.61.80.80.1-0.5-0.6-0.2-0.6-1.0-1.40.7-0.8
Novel to familiar place preference ratio0.10.10.30.2-0.40.10.1-0.20.10.30.6-0.00.1
Novelty place preference0.20.20.70.6-0.30.30.30.00.30.50.8-0.10.1
Time in novel zone, NPP test0.20.20.60.7-0.40.20.2-0.00.20.40.80.1-0.0
Total zone transitions, NPP test1.11.64.22.02.01.11.11.91.20.2-0.00.1-0.2
Total locomotion distance, NPP test0.40.52.11.41.00.40.51.00.4-0.2-0.40.3-0.4
Locomotion velocity, NPP test0.50.61.81.21.40.70.71.20.70.1-0.1-0.0-0.0
Intraocular pressure0.10.10.3-0.6-0.2-0.30.00.40.1-0.10.20.6-0.6
Delta distance traveled before/after self-admin1.31.32.9-0.2-1.1-1.4-1.1-0.8-1.1-1.3-1.11.1-1.7
Delta ambulatory time before/after self-admin1.51.93.90.1-1.2-1.6-1.3-0.9-1.3-1.6-1.41.5-2.0
Parametrial fat weight0.61.52.10.41.11.31.41.11.41.41.5-1.21.2
Pavlov. Cond. lever latency0.00.10.20.2-0.4-0.1-0.2-0.2-0.2-0.1-0.00.4-0.2
Pavlov. Cond. magazine entry latency0.30.43.01.7-0.0-0.3-0.3-0.2-0.3-0.5-0.60.4-0.4
Pavlov. Cond. change in total contacts1.31.44.12.0-0.4-0.9-1.0-0.7-1.0-1.3-1.51.0-1.1
Pavlov. Cond. index score0.20.30.50.6-0.3-0.5-0.5-0.3-0.4-0.6-0.70.4-0.6
Pavlov. Cond. latency score0.10.10.20.4-0.1-0.3-0.3-0.2-0.2-0.3-0.50.1-0.3
Pavlov. Cond. lever contacts0.10.10.20.20.50.10.10.20.20.0-0.2-0.40.2
Pavlov. Cond. magazine entry number0.50.64.5-2.1-0.10.30.3-0.00.30.60.7-0.60.6
Pavlov. Cond. intertrial magazine entries0.40.41.4-0.2-0.0-0.5-0.6-0.3-0.7-0.9-1.20.7-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.60.8-0.1-0.4-0.3-0.1-0.2-0.5-0.60.4-0.5
Pavlov. Cond. response bias0.20.31.51.20.0-0.3-0.3-0.1-0.2-0.5-0.60.3-0.4
Pavlov. Cond. lever latency0.20.32.01.4-0.10.10.30.50.20.00.40.6-0.6
Pavlov. Cond. magazine entry latency0.70.82.50.6-0.4-0.8-1.0-1.0-0.9-1.2-1.60.5-0.6
Pavlov. Cond. change in total contacts2.13.44.9-1.4-1.7-2.0-2.2-2.1-2.1-1.9-2.21.2-1.1
Pavlov. Cond. index score0.30.41.1-0.4-0.2-0.5-0.7-0.8-0.6-0.7-1.00.1-0.1
Pavlov. Cond. latency score0.30.31.3-0.2-0.1-0.5-0.7-0.7-0.6-0.7-1.10.1-0.1
Pavlov. Cond. lever contacts0.30.42.2-1.50.20.0-0.3-0.4-0.10.0-0.3-0.70.6
Pavlov. Cond. magazine entry number0.30.31.0-0.40.20.60.70.60.50.71.0-0.20.4
Pavlov. Cond. intertrial magazine entries0.60.91.80.3-1.2-0.9-0.9-0.8-1.2-0.9-0.61.4-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.31.0-0.7-0.1-0.5-0.7-0.8-0.6-0.6-1.0-0.10.0
Pavlov. Cond. response bias0.40.51.1-0.9-0.4-0.7-0.9-1.0-0.7-0.7-1.10.0-0.1
Time in closed arm before self-admin0.30.41.1-1.00.2-0.1-0.3-0.9-0.2-0.1-0.8-1.00.5
Time in closed arm after self-admin0.50.50.8-0.3-0.8-0.7-0.8-0.9-0.7-0.7-0.80.6-0.6
Time in open arm before self-admin1.11.22.00.91.11.21.31.41.21.01.2-0.50.8
Time in open arm after self-admin1.01.01.50.31.21.11.11.21.11.01.0-1.00.8
Bone: periosteal estimation2.14.49.0-3.0-2.4-2.3-2.2-2.0-2.1-1.9-1.71.6-1.4
Bone: periosteal perimeter2.13.612.6-3.5-2.3-2.0-1.7-1.8-1.7-1.3-0.91.1-1.2
Bone: post-yield work3.14.57.1-0.0-1.9-2.1-2.2-1.6-2.3-2.5-2.42.7-2.4
Progressive ratio test 1 active lever presses2.43.04.60.7-1.5-1.6-1.7-1.4-1.8-2.0-2.02.1-2.0
Progressive ratio test 1 breakpoint2.12.54.10.9-1.3-1.4-1.5-1.1-1.6-1.9-1.82.0-1.9
Progressive ratio test 1 inactive lever presses2.23.24.7-0.0-1.8-1.6-2.0-2.2-2.1-1.9-2.11.8-1.3
Progressive ratio test 2 active lever presses2.32.74.21.0-1.3-1.6-1.6-1.0-1.6-2.0-1.92.0-2.0
Progressive ratio test 2 breakpoint2.22.53.91.1-1.2-1.5-1.5-0.9-1.5-1.9-1.82.0-2.0
Progressive ratio test 2 inactive lever presses0.30.41.10.9-0.1-0.4-0.6-0.4-0.6-0.8-1.10.7-0.6
Incentive Sensitization - Responses0.10.20.90.90.30.00.10.40.2-0.2-0.20.4-0.4
Incentive Sensitization - Breakpoint0.10.10.70.80.1-0.1-0.00.30.0-0.3-0.30.5-0.5
Sum of active levers in priming session hrs 5-60.00.00.1-0.2-0.10.0-0.0-0.2-0.00.1-0.0-0.20.2
Progressive ratio0.10.20.5-0.5-0.4-0.4-0.5-0.7-0.5-0.5-0.60.3-0.1
Food seeking constrained by brief footshock0.81.01.5-0.3-1.1-1.1-1.1-0.7-1.0-1.1-0.81.2-1.2
Seeking ratio, punishment vs. effort0.20.40.80.2-0.7-0.7-0.6-0.3-0.6-0.6-0.40.7-0.9
Retroperitoneal fat weight0.62.713.6-3.7-2.5-1.5-1.0-1.2-1.0-0.30.60.9-0.8
Reaction time number correct1.32.54.60.11.91.61.82.11.91.51.6-1.31.0
Reaction time mean minus median0.10.20.70.80.10.30.2-0.20.10.40.3-0.50.6
Reaction time mean minus median AUC0.10.30.70.4-0.00.50.3-0.10.30.80.8-0.80.8
Reaction time num false alarms0.30.40.8-0.10.40.60.60.20.60.70.6-0.90.9
Reaction time num false alarms AUC0.40.71.0-0.10.80.90.90.60.90.90.8-0.91.0
Reaction time trials correct on left1.32.54.60.11.91.61.82.11.91.51.6-1.31.0
Reaction time trials on left1.42.64.80.12.01.61.92.21.91.51.6-1.31.1
Reaction time mean0.20.30.90.60.20.50.2-0.10.20.60.4-0.71.0
Reaction time mean AUC0.20.20.60.80.30.40.30.00.20.50.4-0.60.8
Median of all reaction times0.20.30.90.60.30.50.3-0.00.20.60.4-0.70.9
Reaction time omissions0.30.41.21.10.80.70.60.70.50.50.4-0.40.5
Reaction time false alarm rate0.10.10.3-0.2-0.20.10.1-0.40.00.30.2-0.40.6
Reaction time premature initiation rate1.62.23.0-1.6-1.4-1.6-1.7-1.6-1.5-1.5-1.70.9-0.9
Reaction time premature initiations0.30.61.9-1.4-0.5-0.8-0.8-0.6-0.6-0.7-0.80.3-0.5
Std. dev. reaction times0.10.20.60.50.00.40.2-0.10.10.60.5-0.50.8
Reaction time trials completed1.42.64.80.12.01.61.92.21.91.51.6-1.31.1
Reaction time trials AUC1.02.03.8-0.31.71.41.61.91.61.31.4-1.10.9
Run reversals in cocaine runway, females0.60.61.01.00.90.80.70.90.60.70.6-0.50.5
Run reversals in cocaine runway, males0.70.72.91.7-0.2-0.20.00.6-0.1-0.5-0.11.3-1.2
Latency to leave start box in cocaine runway0.30.30.9-0.40.00.30.40.20.40.80.9-0.80.5
Latency to leave start box in cocaine runway, F0.00.10.1-0.00.10.20.10.10.10.30.3-0.40.3
Latency to leave start box in cocaine runway, M0.60.61.4-0.90.00.40.70.20.81.01.2-0.90.6
Std. dev. time between licks in bursts0.20.31.1-0.6-0.1-0.6-0.4-0.5-0.4-0.7-1.00.1-0.4
Total sessions with >9 infusions4.85.88.2-0.7-2.9-2.6-2.6-2.4-2.7-2.4-2.12.5-2.5
Short access day 1 total inactive lever presses6.99.112.1-0.6-2.9-3.2-3.4-3.2-3.5-3.3-3.52.6-2.8
Short access day 10 total inactive lever presses0.10.30.5-0.2-0.7-0.6-0.7-0.6-0.7-0.5-0.40.6-0.3
Short access day 1 total infusions2.23.04.1-0.7-1.9-1.8-2.0-2.0-2.0-1.7-1.71.5-1.5
Short access day 10 total infusions2.73.44.9-0.4-2.2-2.0-2.1-2.1-2.1-1.8-1.71.8-1.7
Short access total infusions5.67.28.8-0.4-3.0-2.9-2.9-2.8-3.0-2.8-2.62.7-2.7
Short access day 1 locomotion0.70.92.0-0.7-1.1-0.8-1.1-1.4-1.2-0.7-0.90.5-0.4
Short access day 10 total locomotion0.30.62.0-1.0-0.6-0.2-0.9-1.4-0.9-0.3-0.7-0.10.3
Short access total locomotion1.61.94.0-1.3-1.7-1.2-1.6-2.0-1.6-1.1-1.20.8-0.8
One hour access (0.3 mA shock)0.30.41.01.0-0.2-0.2-0.6-0.6-0.7-0.7-0.90.6-0.1
Compulsive drug intake0.60.73.61.90.70.00.21.10.2-0.6-0.50.7-0.8
One hour access (shock baseline)0.20.31.1-0.6-0.5-0.2-0.5-1.0-0.6-0.1-0.3-0.10.5
Social response proportion0.30.41.5-0.6-0.6-0.1-0.4-1.2-0.40.30.1-0.80.7
Social responses0.10.20.70.90.0-0.1-0.3-0.1-0.3-0.4-0.50.5-0.4
Social time0.20.21.31.10.70.40.10.00.1-0.0-0.5-0.20.3
Soleus weight0.20.61.71.3-0.0-0.5-0.30.1-0.3-1.0-1.01.0-1.1
Bone: stiffness3.35.47.4-2.5-2.7-2.6-2.6-2.7-2.4-2.2-2.11.6-1.7
Tibialis anterior weight0.10.31.41.20.50.20.1-0.20.4-0.2-0.6-0.40.1
Time to tail flick, vehicle, before self-admin0.30.30.50.2-0.6-0.6-0.6-0.6-0.6-0.6-0.70.4-0.6
Time to tail flick, vehicle, after self-admin0.10.10.40.20.60.40.40.40.40.20.0-0.40.4
Time to tail flick, test, before self-admin0.20.20.50.70.30.40.60.70.60.40.60.1-0.0
Time to tail flick, test, after self-admin0.30.30.60.50.80.60.60.60.50.50.4-0.60.5
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.5-0.3-0.3-0.4-0.5-0.4-0.3-0.40.2-0.1
Delta time to tail flick, test, before/after SA0.60.61.5-0.21.20.80.60.60.60.60.2-1.21.0
Tibia length0.92.53.9-1.5-1.6-1.8-1.4-0.9-1.5-1.7-1.32.0-2.0
Ambulatory time before self-admin0.00.10.20.40.40.40.2-0.00.20.2-0.1-0.20.4
Ambulatory time after self-admin0.50.61.80.7-0.2-0.7-0.7-0.6-0.7-1.0-1.30.6-1.0
Bone: tissue strength0.50.54.4-2.1-0.2-0.3-0.00.2-0.1-0.20.10.4-0.3
Total heroin consumption1.01.21.90.2-1.0-1.3-1.1-0.7-1.1-1.3-1.21.3-1.4
Bone: trabecular number0.30.62.9-1.70.50.40.60.70.70.50.6-0.50.4
Bone: trabecular spacing3.04.05.20.1-2.1-2.1-2.1-1.8-2.2-2.2-1.92.3-2.2
Bone: trabecular thickness0.91.12.2-1.50.70.80.70.40.81.10.9-1.51.5
Bone: trabecular tissue density0.30.41.50.40.60.50.2-0.30.40.5-0.1-1.21.0
Water consumed over 24 hours1.21.64.12.0-1.0-0.9-1.1-0.9-1.1-1.2-1.11.4-1.4
Number of responses in last shaping day2.42.75.6-1.2-1.6-1.7-1.8-2.4-1.8-1.6-2.00.7-1.0