Hub : Genes

Tnfrsf11a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Tnfrsf11a 0.2 0.13 2.6e-03 0.09 0.01 0 0.04 4.1e-03 1.7e-01 2.3e-01 4.0e-02
2 Liver alternative TSS NM_001271235.1 0.03 0.02 3.8e-03 0.01 0.01 0.01 0.01 1.0e-02 2.3e-02 1.1e-02 3.3e-02
3 Liver isoform ratio NM_001271235.1 0.07 0.06 4.6e-04 0.03 0.01 0.03 0.02 6.7e-04 7.0e-03 8.2e-04 1.9e-03
4 Liver alternative TSS XM_008769487.4 0.13 0.07 5.9e-14 0.09 0.1 0.1 0.09 1.6e-10 5.3e-11 1.1e-10 1.3e-10
5 BLA gene expression Tnfrsf11a 0.08 0.06 5.9e-03 0.02 0.01 0.02 0.02 3.7e-02 6.4e-02 3.6e-02 4.6e-02
6 Brain mRNA stability Tnfrsf11a 0.15 0.1 3.7e-09 0.03 0.08 0.08 0.08 6.7e-04 4.6e-08 4.1e-08 7.7e-08
7 Liver gene expression Tnfrsf11a 0.63 0.12 0.0e+00 0.48 0.5 0.5 0.5 2.4e-59 6.0e-64 7.3e-64 6.6e-64
8 NAcc gene expression Tnfrsf11a 0.06 0.05 6.4e-04 0 0.01 0.01 0.01 5.6e-02 1.8e-02 2.5e-02 3.4e-02
9 Adipose mRNA stability Tnfrsf11a 0.08 0.05 1.6e-05 0.02 0 0 0.01 6.0e-03 9.1e-02 8.0e-02 4.3e-02
10 Brain gene expression Tnfrsf11a 0.21 0.12 5.6e-15 0.12 0.15 0.16 0.16 2.4e-11 6.3e-14 1.6e-14 2.6e-14
11 pVTA gene expression Tnfrsf11a 0.13 0.09 5.0e-06 0.02 0.04 0.04 0.03 1.4e-02 4.3e-04 4.0e-04 1.2e-03
12 PL gene expression Tnfrsf11a 0.04 0.03 4.2e-03 0 0.01 0.01 0.01 8.8e-02 2.0e-02 4.8e-02 3.0e-02
13 NAcc mRNA stability Tnfrsf11a 0.12 0.08 1.1e-09 0.05 0.05 0.06 0.06 1.7e-08 2.9e-08 4.2e-09 1.0e-08
14 PL mRNA stability Tnfrsf11a 0.09 0.06 3.1e-05 0.04 0.03 0.04 0.04 4.1e-05 2.8e-04 8.2e-05 9.8e-05
15 Adipose gene expression Tnfrsf11a 0.41 0.15 1.4e-04 0.02 0.03 0.02 0.01 3.5e-03 3.7e-04 8.8e-04 8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.32.1-0.20.10.2-0.0-0.10.0-0.00.1-0.50.30.30.5-0.6-0.71.4
Area under the delay curve1.31.52.91.7-1.7-1.71.51.4-1.31.41.21.70.90.80.6-0.30.40.0
BMI with tail2.07.09.12.5-2.6-2.82.82.7-2.82.93.00.53.03.03.0-2.8-2.51.7
BMI without tail1.02.94.31.4-1.5-1.61.71.6-1.61.81.9-0.12.12.02.1-1.9-2.01.2
Body weight3.113.416.93.9-4.0-4.14.14.0-4.04.14.12.03.93.83.7-3.3-2.42.6
Weight adjusted by age1.01.52.91.0-1.0-1.01.21.2-1.71.31.30.41.41.41.4-1.2-1.11.3
Bone surface0.40.73.1-0.0-0.00.10.30.1-0.40.30.5-1.00.80.81.0-1.2-1.21.8
Bone volume0.10.10.6-0.30.30.3-0.2-0.20.0-0.1-0.0-0.40.00.10.2-0.4-0.30.8
Breakpoint value in progressive ratio session0.50.71.20.7-0.8-0.80.90.8-1.10.90.90.21.00.90.9-0.7-0.60.5
Number of licking bursts0.50.83.51.2-1.1-1.10.81.0-0.70.70.51.90.20.2-0.00.20.9-0.3
Context. condit. distance diff. score0.10.10.8-0.10.10.0-0.1-0.1-0.2-0.1-0.20.2-0.3-0.3-0.30.40.7-0.9
Locomotion velocity, session 10.20.20.40.3-0.4-0.40.50.6-0.40.50.50.30.50.60.6-0.5-0.70.2
Locomotion distance, session 10.70.93.61.3-1.3-1.21.01.2-0.70.80.71.90.40.30.10.10.60.5
Locomotion velocity, session 20.70.82.21.2-1.2-1.11.01.2-0.71.00.81.50.60.60.4-0.10.10.4
Locomotion distance, session 21.42.06.11.9-2.0-1.81.61.8-1.11.41.22.50.90.80.5-0.20.50.8
Locomotion velocity, session 30.20.20.7-0.50.50.6-0.5-0.50.8-0.5-0.5-0.5-0.4-0.4-0.30.2-0.10.2
Locomotion distance, session 30.20.21.0-0.30.40.4-0.2-0.30.1-0.10.1-1.00.30.20.4-0.6-0.80.8
Stereotopy head waving bouts, day 30.30.31.10.6-0.6-0.70.50.5-0.70.50.31.00.00.2-0.00.30.7-1.1
Stereotopy head waving duration, day 30.30.41.9-0.20.10.0-0.3-0.20.2-0.2-0.40.5-0.6-0.5-0.70.90.9-1.4
Locomotion velocity, session 72.22.43.8-1.91.91.8-1.8-1.81.5-1.7-1.7-1.4-1.5-1.4-1.31.10.5-1.3
Locomotion distance, session 70.20.20.4-0.40.40.4-0.5-0.40.4-0.5-0.50.1-0.6-0.6-0.60.60.6-0.6
Stereotopy head waving bouts, day 70.10.20.80.4-0.4-0.40.20.30.40.1-0.00.9-0.2-0.3-0.40.50.5-0.3
Stereotopy head waving duration, day 70.00.10.4-0.10.00.0-0.1-0.00.6-0.1-0.10.1-0.2-0.2-0.20.3-0.1-0.4
Locomotion velocity, session 82.63.15.2-1.21.31.2-1.6-1.41.4-1.6-1.80.7-2.0-2.1-2.22.32.3-2.3
Locomotion distance, session 80.20.31.50.5-0.4-0.40.10.3-0.00.0-0.11.2-0.3-0.4-0.50.61.0-0.1
Degree of sensitization distance0.60.71.8-0.20.20.2-0.4-0.30.3-0.5-0.70.9-0.9-0.9-1.11.21.4-1.3
Degree of sensitization stereotypy0.10.10.50.4-0.4-0.30.20.30.50.10.10.7-0.1-0.2-0.20.30.10.4
Conditioned locomotion0.30.41.40.8-0.8-0.80.70.8-0.70.60.51.20.40.30.20.10.3-0.0
Cocaine response after cond. corrected1.11.34.7-1.01.00.8-1.0-1.10.7-1.0-1.1-0.4-1.1-1.1-1.11.21.0-2.2
Cocaine response after cond. not corrected1.82.14.9-1.41.41.2-1.4-1.51.3-1.4-1.5-0.7-1.5-1.4-1.51.51.0-2.2
Cocaine response before conditioning0.30.41.2-0.60.60.6-0.7-0.51.1-0.7-0.7-0.4-0.6-0.6-0.60.60.1-0.2
Saline control response1.31.77.00.1-0.2-0.2-0.3-0.1-0.1-0.5-0.82.0-1.3-1.3-1.62.02.6-2.0
Bone: connectivity density0.30.52.6-0.50.30.4-0.2-0.30.1-0.10.1-1.10.30.30.6-0.8-1.01.6
Bone: cortical apparent density1.31.82.9-1.01.01.1-1.3-1.31.4-1.5-1.50.1-1.6-1.7-1.71.51.5-0.7
Bone: cortical area0.10.10.3-0.40.20.3-0.3-0.30.0-0.4-0.3-0.1-0.3-0.3-0.20.10.30.6
Bone: cortical porosity3.33.54.41.9-2.1-2.02.12.0-2.12.12.11.02.12.02.0-1.7-1.21.3
Bone: cortical porosity3.53.85.52.0-2.2-2.22.22.0-2.32.22.21.12.12.02.0-1.8-1.11.4
Bone: cortical thickness0.71.11.9-1.41.21.2-1.3-1.30.5-1.3-1.2-0.8-1.0-1.1-0.90.70.8-0.3
Bone: cortical thickness0.40.50.8-0.80.70.8-0.8-0.90.4-0.9-0.8-0.1-0.7-0.8-0.70.60.80.1
Bone: cortical tissue density1.21.72.7-0.90.91.0-1.3-1.21.3-1.4-1.40.2-1.6-1.6-1.61.51.5-0.8
Condit. Reinf. active minus inactive responses2.02.33.11.5-1.6-1.71.71.6-1.81.71.70.61.61.71.6-1.4-1.10.7
Condit. Reinf. active-inactive response ratio0.10.10.70.0-0.1-0.2-0.0-0.00.0-0.0-0.10.1-0.2-0.1-0.20.30.2-0.8
Condit. Reinf. active responses2.02.43.11.4-1.5-1.51.61.6-1.61.71.70.31.81.81.8-1.6-1.51.4
Condit. Reinf. inactive responses0.50.62.50.4-0.4-0.30.60.6-0.50.60.7-0.20.90.80.9-0.9-1.11.6
Incentive salience index mean2.53.13.91.7-1.7-1.81.91.8-1.91.92.00.52.02.02.0-1.8-1.51.4
Condit. Reinf. lever presses1.21.72.91.1-1.1-1.01.31.3-1.11.31.40.21.51.41.5-1.4-1.51.7
Condit. Reinf. active minus inactive responses1.52.03.90.8-0.7-0.81.20.9-1.81.31.5-0.91.71.81.9-2.0-1.71.0
Condit. Reinf. active-inactive response ratio1.21.42.01.1-1.1-1.11.31.3-1.31.31.30.31.41.41.4-1.2-1.20.6
Condit. Reinf. active responses4.25.810.31.8-1.7-1.92.32.0-3.22.52.6-0.52.93.03.0-3.0-2.41.7
Condit. Reinf. inactive responses2.22.95.71.0-1.0-1.11.41.1-2.41.61.8-0.92.02.12.2-2.4-1.71.6
Condit. Reinf. lever presses2.12.94.02.0-1.8-1.91.91.9-2.01.91.90.91.81.81.7-1.5-1.01.0
Condit. Reinf. lever reinforcers received3.75.19.51.9-1.8-2.02.32.0-3.12.42.5-0.12.72.72.7-2.7-2.01.4
Conditioned reinforcement - actives2.03.45.71.6-1.5-1.51.81.6-1.71.82.0-0.02.12.02.2-2.3-2.02.4
Conditioned reinforcement - inactives0.20.41.20.1-0.1-0.10.30.3-0.50.40.5-0.40.80.70.8-0.8-1.10.8
Conditioned locomotion1.21.54.30.7-0.5-0.50.90.8-0.70.91.1-0.71.41.41.5-1.8-1.92.1
Patch foraging indifference point 0 sec0.51.04.91.0-0.9-1.00.60.7-0.60.40.22.2-0.3-0.3-0.50.81.7-1.2
Patch foraging indifference point AUC0.10.10.60.2-0.2-0.20.0-0.0-0.2-0.0-0.10.5-0.2-0.2-0.30.40.6-0.8
Delay disc. indifference point, 0s delay0.70.82.51.4-1.2-1.21.00.9-0.70.80.61.60.30.20.00.11.0-0.1
Delay disc. indifference point, 16s delay2.02.23.91.7-2.0-2.01.71.8-1.81.71.51.81.31.21.0-0.5-0.10.0
Delay disc. indifference point, 2s delay0.20.31.10.4-0.4-0.40.20.2-0.10.2-0.00.9-0.3-0.3-0.40.61.0-0.8
Delay disc. indifference point, 24s delay1.11.22.01.3-1.4-1.41.31.4-1.31.31.21.41.01.00.8-0.4-0.10.1
Delay disc. indifference point, 4s delay2.52.66.42.2-2.2-2.21.91.9-1.71.71.52.51.00.90.6-0.10.8-0.3
Delay disc. indifference point, 8s delay0.10.10.40.7-0.5-0.50.30.2-0.10.20.10.6-0.1-0.1-0.20.10.60.0
Indifference point function ln k0.30.51.40.8-0.8-0.70.70.8-0.30.70.70.40.70.70.7-0.6-0.71.2
Indifference point function log k0.30.51.40.8-0.8-0.70.70.8-0.30.70.70.40.70.70.7-0.6-0.71.2
Patch foraging total patch changes 0 sec0.61.15.21.1-1.0-1.10.70.9-0.80.60.32.3-0.2-0.2-0.50.71.6-1.3
Patch foraging total patch changes 12 sec0.70.83.90.3-0.2-0.2-0.1-0.0-0.4-0.3-0.51.7-0.9-0.8-1.01.22.0-1.2
Patch foraging total patch changes 18 sec0.50.74.00.2-0.1-0.2-0.2-0.2-0.2-0.2-0.51.0-0.8-0.7-0.90.91.6-2.0
Patch foraging total patch changes 24 sec0.50.94.2-0.10.20.0-0.4-0.40.2-0.5-0.70.9-1.0-0.9-1.11.01.6-2.1
Patch foraging total patch changes 6 sec0.91.34.5-0.20.0-0.0-0.5-0.40.1-0.6-0.81.4-1.3-1.2-1.41.62.1-2.1
Patch foraging time to switch 0 sec0.00.10.5-0.30.20.2-0.3-0.2-0.0-0.2-0.30.1-0.3-0.2-0.30.30.4-0.7
Patch foraging water rate 0 sec0.00.00.1-0.10.20.2-0.2-0.20.1-0.2-0.20.1-0.2-0.2-0.20.20.2-0.2
Patch foraging water rate 12 sec0.10.10.6-0.10.10.10.10.10.00.20.3-0.40.40.40.5-0.4-0.80.4
Patch foraging water rate 18 sec0.40.61.0-1.01.01.0-0.9-0.91.0-0.8-0.8-0.7-0.6-0.7-0.50.40.0-0.1
Patch foraging water rate 24 sec0.60.91.91.2-1.2-1.11.11.1-1.01.00.91.40.70.60.6-0.4-0.00.7
Patch foraging water rate 6 sec0.20.30.6-0.70.70.8-0.6-0.70.6-0.6-0.5-0.7-0.3-0.4-0.20.1-0.20.5
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.40.20.2-0.2-0.30.7-0.2-0.2-0.5-0.1-0.1-0.00.0-0.40.1
Distance traveled before self-admin0.60.83.5-0.1-0.0-0.0-0.3-0.10.4-0.3-0.61.0-0.8-0.9-1.11.51.6-1.9
Distance traveled after self-admin1.11.44.4-0.90.60.6-0.9-0.70.6-0.9-1.10.4-1.1-1.2-1.31.81.7-2.1
Extensor digitorum longus weight0.41.44.21.4-1.6-1.51.31.3-1.61.21.02.00.70.70.4-0.00.8-0.1
Bone: elastic displacement1.11.33.2-1.41.41.4-1.3-1.31.8-1.2-1.1-1.6-0.9-0.8-0.70.3-0.50.1
Bone: elastic work2.93.85.7-2.12.02.0-2.2-2.12.4-2.2-2.2-1.1-2.2-2.1-2.01.81.1-1.2
Bone: endosteal estimation0.30.62.01.2-1.1-1.00.91.1-0.30.80.71.40.40.40.2-0.10.20.7
Bone: endosteal perimeter0.61.32.21.5-1.4-1.31.31.4-1.21.31.21.40.91.00.8-0.7-0.00.9
Epididymis fat weight0.93.18.80.7-0.6-0.71.20.8-1.21.31.6-1.72.02.12.3-2.6-3.02.2
Delta time in closed arm before/after self-admin0.10.10.50.3-0.3-0.30.20.4-0.40.20.10.70.10.0-0.10.20.2-0.3
Delta time in open arm before/after self-admin0.50.51.90.7-0.8-0.80.40.5-0.30.30.11.4-0.2-0.3-0.40.61.3-0.8
Diff in mean of infusions in LGA sessions0.40.50.7-0.80.70.7-0.8-0.80.6-0.8-0.8-0.4-0.8-0.8-0.80.70.7-0.7
Delay discount exponential model param1.41.63.1-1.71.71.7-1.5-1.41.3-1.4-1.2-1.8-0.8-0.8-0.60.2-0.50.1
Extinction: sum of active levers before priming0.91.02.0-1.41.31.3-1.2-1.20.5-1.1-1.0-1.0-0.9-0.8-0.70.70.5-0.9
Active lever presses in extinction session 60.00.00.3-0.20.00.0-0.1-0.30.0-0.00.0-0.50.10.00.1-0.1-0.1-0.1
Bone: final force0.10.21.10.4-0.4-0.20.30.3-0.50.30.30.20.30.20.3-0.40.01.1
Bone: final moment0.20.21.20.5-0.5-0.40.40.4-0.70.40.40.30.40.30.4-0.40.11.1
Food consumed during 24 hour testing period1.62.23.71.7-1.7-1.71.71.8-1.91.71.61.41.41.51.3-1.0-0.50.4
Glucose2.74.25.92.4-2.4-2.32.42.4-2.12.32.31.42.12.01.9-1.6-1.11.5
Heart weight1.42.14.31.3-1.2-1.31.51.3-2.11.51.60.21.81.61.7-1.6-1.11.0
Delay discount hyperbolic model param1.01.22.7-1.51.51.5-1.3-1.21.1-1.2-1.0-1.6-0.6-0.6-0.40.1-0.60.2
Intermittent access intake day 1-15 change0.20.41.6-0.80.90.9-0.6-0.90.3-0.6-0.4-1.3-0.1-0.20.0-0.3-0.50.5
Intermittent access intake escalation0.30.72.3-1.11.21.2-0.9-1.10.6-0.8-0.7-1.5-0.4-0.4-0.2-0.1-0.40.4
Intermittent access intake escalation 20.30.30.7-0.70.80.8-0.7-0.80.4-0.6-0.5-0.8-0.4-0.4-0.30.10.10.1
Intermitt. access day 1 inactive lever presses0.20.71.11.1-1.0-1.01.01.0-0.80.90.90.90.80.80.7-0.7-0.30.5
Intermitt. access day 15 inactive lever presses0.10.10.20.2-0.3-0.30.30.3-0.20.30.40.10.40.40.4-0.4-0.40.3
Intermitt. access escalation Index0.20.21.10.6-0.5-0.50.20.40.10.1-0.01.0-0.3-0.3-0.40.50.8-0.4
Intermittent access day 1 total infusions0.20.31.3-0.10.20.20.10.1-0.20.10.3-0.90.50.50.6-0.8-1.10.9
Intermittent access day 15 total infusions0.30.41.5-0.40.40.4-0.1-0.2-0.1-0.10.1-1.20.40.40.6-0.9-1.11.1
Intermittent access terminal intake (last 3 days)0.20.31.00.1-0.1-0.10.20.2-0.50.30.4-0.50.60.60.7-0.8-0.91.0
Intermittent access total infusions0.70.82.40.3-0.2-0.20.50.4-0.70.60.8-0.81.01.01.1-1.3-1.51.5
Intermittent access day 1 locomotion0.10.10.4-0.20.20.2-0.2-0.10.1-0.1-0.0-0.50.10.10.1-0.3-0.50.6
Intermittent access day 15 total locomotion0.50.92.20.5-0.5-0.50.70.7-0.80.80.9-0.41.11.11.2-1.3-1.41.5
Intermittent access total locomotion0.81.03.00.2-0.2-0.20.50.5-0.70.60.8-0.91.11.11.3-1.4-1.71.7
Intermittent access standard deviation0.00.00.0-0.20.10.1-0.1-0.20.1-0.1-0.1-0.1-0.1-0.1-0.10.10.2-0.2
Left kidney weight1.15.111.63.0-3.0-3.12.62.8-2.42.42.13.41.51.51.1-0.60.40.1
Right kidney weight0.93.911.82.6-2.6-2.72.12.3-2.21.91.63.41.00.90.50.01.3-0.6
Cocaine induced anxiety0.10.20.9-0.30.30.3-0.1-0.1-0.20.00.1-0.70.40.40.5-0.6-0.90.7
Post-drug Anxiety0.20.21.1-0.50.40.4-0.1-0.0-0.40.00.2-0.70.40.50.6-0.5-1.00.4
Baseline Anxiety0.10.10.40.1-0.3-0.30.30.3-0.60.40.30.20.40.30.30.1-0.1-0.4
Tail length0.41.52.11.4-1.3-1.41.41.4-1.31.41.40.81.41.31.2-1.0-0.80.7
Length with tail1.56.510.43.2-3.2-3.23.03.0-2.82.92.72.72.42.32.0-1.5-0.51.3
Length without tail1.03.36.52.2-2.4-2.42.12.2-2.12.01.82.61.41.31.1-0.60.30.3
Times rat made contact with spout0.10.10.60.1-0.0-0.1-0.0-0.0-0.4-0.1-0.10.5-0.3-0.2-0.30.40.8-0.6
Lifetime Intake0.60.71.80.3-0.3-0.30.50.4-0.70.50.7-0.70.90.91.0-1.2-1.41.3
Liver weight, left1.52.56.41.5-1.6-1.81.71.6-2.51.81.71.11.61.81.6-1.3-0.5-0.3
Liver weight, right1.93.36.11.9-2.1-2.22.11.9-2.52.12.01.51.81.91.7-1.3-0.6-0.2
Locomotor activity0.81.22.11.2-1.3-1.41.31.4-1.11.41.21.41.01.00.8-0.3-0.0-0.3
Locomotor testing distance0.40.71.60.9-1.0-1.00.90.9-1.00.90.81.30.60.60.4-0.10.5-0.6
Locomotor testing rearing0.10.31.3-0.0-0.0-0.0-0.1-0.1-0.0-0.1-0.30.8-0.4-0.4-0.50.71.1-1.1
Locomotion in novel chamber0.10.20.7-0.1-0.2-0.2-0.1-0.1-0.1-0.1-0.20.3-0.4-0.4-0.40.60.8-0.8
Locomotion in novel chamber post-restriction0.00.00.10.0-0.3-0.30.10.1-0.30.10.00.1-0.0-0.0-0.00.10.3-0.1
Fecal boli incidents, locomotor time 10.20.31.1-0.1-0.1-0.10.20.2-0.20.30.4-0.70.60.50.6-0.6-1.01.0
Change in fecal boli incidents, locomotor task0.50.50.8-0.60.80.8-0.8-0.90.9-0.8-0.8-0.7-0.7-0.7-0.60.20.2-0.1
Time >=10cm from walls, locomotor time 10.20.20.70.6-0.5-0.50.10.2-0.00.1-0.10.8-0.4-0.3-0.40.20.8-0.5
Bouts of movement, locomotor time 10.10.10.70.5-0.4-0.40.40.2-0.10.30.40.20.20.30.3-0.5-0.10.8
Total resting periods, locomotor time 10.20.20.70.5-0.4-0.40.50.3-0.20.40.50.20.40.40.5-0.6-0.30.8
Rest time, locomotor task time 10.20.20.9-0.30.20.20.1-0.20.10.10.2-0.80.30.40.5-0.6-1.00.9
Distance moved, locomotor task time 10.91.45.61.2-1.4-1.41.01.3-1.10.90.62.40.20.1-0.20.81.4-1.4
Vertical activity count, locomotor time 10.30.82.6-0.20.30.3-0.5-0.20.3-0.6-0.80.9-0.9-1.0-1.21.41.6-1.5
Time >=10cm from walls, locomotor time 20.81.21.7-1.11.01.0-1.2-1.11.0-1.2-1.2-0.4-1.3-1.2-1.21.11.0-1.2
Bouts of movement, locomotor time 20.71.21.81.2-1.3-1.31.31.2-1.11.31.20.91.11.11.0-0.7-0.50.7
Total resting periods, locomotor time 20.81.52.41.4-1.5-1.51.51.3-1.21.41.41.11.11.21.1-0.8-0.50.8
Rest time, locomotor task time 20.20.20.90.4-0.3-0.30.50.4-0.20.40.50.00.40.50.5-0.5-0.50.9
Distance moved, locomotor task time 20.70.83.50.8-1.0-1.00.70.9-0.90.70.41.90.10.1-0.20.81.1-1.2
Vertical activity count, locomotor time 20.50.62.2-0.30.20.2-0.4-0.0-0.0-0.4-0.61.0-0.7-0.8-0.91.31.4-1.5
Light reinforcement 11.43.44.32.0-1.9-1.82.01.8-1.92.02.10.92.01.91.9-1.8-1.21.7
Light reinforcement 20.71.02.60.2-0.1-0.20.60.2-0.70.60.9-1.31.11.11.4-1.6-1.61.6
Bone: marrow area0.20.51.91.0-1.0-0.80.70.9-0.10.60.51.40.20.20.00.10.30.6
Bone: maximum diameter0.20.41.70.6-0.6-0.50.60.6-0.30.50.60.40.50.50.5-0.5-0.41.3
Bone: maximum force0.10.20.7-0.0-0.00.2-0.3-0.20.4-0.4-0.30.4-0.5-0.5-0.50.30.60.8
Bone: maximum moment0.10.10.70.2-0.2-0.0-0.1-0.00.1-0.2-0.20.6-0.3-0.3-0.30.30.60.9
Mean time between licks in bursts0.92.24.0-2.01.91.8-1.7-1.81.4-1.6-1.5-1.8-1.2-1.1-1.00.70.0-1.0
Mean num. licks in bursts0.40.73.3-1.11.11.1-0.8-0.90.5-0.7-0.5-1.8-0.2-0.20.0-0.2-0.70.3
Cd content in liver0.20.20.80.4-0.4-0.50.40.4-0.90.40.40.60.20.30.2-0.10.3-0.6
Co content in liver4.85.611.8-3.23.23.2-2.7-3.02.3-2.6-2.3-3.4-1.7-1.6-1.20.6-0.3-0.2
Cu content in liver5.66.68.6-2.42.52.4-2.7-2.62.9-2.7-2.8-0.7-2.8-2.9-2.92.82.1-2.5
Fe content in liver2.22.73.6-1.81.91.9-1.9-1.91.7-1.9-1.8-1.3-1.7-1.7-1.61.40.9-0.8
K content in liver0.10.10.2-0.20.20.3-0.2-0.10.3-0.1-0.1-0.30.10.00.1-0.1-0.30.4
Mg content in liver0.50.50.9-0.90.90.9-0.8-0.80.5-0.8-0.7-0.5-0.6-0.6-0.50.60.4-0.5
Mn content in liver0.10.10.30.00.00.0-0.1-0.1-0.0-0.1-0.10.4-0.2-0.2-0.20.40.5-0.3
Na content in liver0.70.82.7-0.50.40.30.1-0.2-0.70.30.5-1.60.91.01.2-1.3-1.50.5
Rb content in liver3.74.37.1-2.72.72.6-2.4-2.42.2-2.3-2.2-2.3-1.9-1.8-1.61.30.4-1.0
Se content in liver1.21.42.7-1.51.51.5-1.3-1.41.5-1.3-1.2-1.6-0.9-0.9-0.80.6-0.1-0.4
Sr content in liver2.01.72.51.2-1.2-1.41.41.3-1.51.51.50.21.51.61.6-1.5-1.1-0.1
Zn content in liver0.50.61.90.9-0.8-1.00.70.7-0.50.60.41.40.10.1-0.10.50.9-1.3
Bone: minimum diameter0.10.22.10.4-0.4-0.20.30.3-0.00.20.30.30.20.10.2-0.3-0.11.4
Time in familiar zone, hab. session 12.01.93.6-1.31.31.4-1.5-1.51.9-1.6-1.5-0.2-1.5-1.6-1.51.40.9-0.5
Time in novel zone, hab. session 10.40.41.10.1-0.1-0.30.40.4-0.50.50.6-0.90.80.80.9-0.9-1.10.1
Total zone transitions, hab. session 10.60.81.81.3-1.4-1.31.11.1-0.61.00.91.20.70.60.5-0.4-0.10.5
Total locomotion distance, hab. session 10.30.41.40.9-0.9-0.90.50.6-0.20.40.31.20.0-0.1-0.20.40.8-0.3
Locomotion velocity, hab. session 10.40.52.11.0-1.1-1.00.60.7-0.30.50.31.40.0-0.1-0.20.40.9-0.1
Time in familiar zone, hab. session 21.71.82.8-1.21.21.2-1.4-1.41.0-1.5-1.60.0-1.7-1.6-1.61.41.5-0.9
Time in novel zone, hab. session 21.51.62.51.0-1.0-1.11.31.2-0.91.41.4-0.21.61.51.5-1.4-1.60.8
Total zone transitions, hab. session 21.92.53.61.9-1.9-1.81.81.9-1.41.71.71.41.51.41.4-1.2-0.81.3
Total locomotion distance, hab. session 22.12.75.42.2-2.3-2.21.92.1-1.61.71.62.31.21.11.0-0.60.10.9
Locomotion velocity, hab. session 21.52.04.51.9-2.0-1.91.61.8-1.21.51.32.11.00.90.7-0.40.20.8
Novel to familiar place preference ratio3.74.06.92.6-2.6-2.52.32.4-1.62.22.12.21.81.61.5-1.3-0.71.6
Novelty place preference3.13.45.92.4-2.4-2.32.12.2-1.52.01.92.01.71.51.4-1.2-0.71.5
Time in novel zone, NPP test3.74.06.32.5-2.5-2.42.32.3-1.72.22.11.91.91.71.7-1.5-0.91.6
Total zone transitions, NPP test0.81.13.10.5-0.6-0.60.80.7-0.80.81.0-0.71.31.21.3-1.5-1.51.8
Total locomotion distance, NPP test0.70.91.91.3-1.4-1.31.11.1-1.01.00.91.20.70.60.5-0.30.20.8
Locomotion velocity, NPP test0.30.41.00.9-1.0-0.90.70.7-0.50.60.50.90.40.20.2-0.10.30.6
Intraocular pressure0.50.81.91.1-1.0-1.10.91.0-1.30.90.71.40.50.50.30.00.6-0.8
Delta distance traveled before/after self-admin0.20.20.5-0.70.60.6-0.6-0.60.1-0.5-0.5-0.5-0.4-0.4-0.30.30.3-0.2
Delta ambulatory time before/after self-admin0.10.10.2-0.50.40.4-0.4-0.40.2-0.4-0.3-0.3-0.3-0.3-0.20.20.20.0
Parametrial fat weight1.74.18.51.2-1.3-1.41.81.7-1.61.92.1-0.72.52.52.6-2.5-2.92.2
Pavlov. Cond. lever latency1.51.93.1-1.81.81.6-1.6-1.71.2-1.5-1.5-1.5-1.2-1.2-1.10.90.4-1.1
Pavlov. Cond. magazine entry latency0.10.10.1-0.40.30.3-0.3-0.20.3-0.4-0.30.1-0.3-0.4-0.30.40.20.2
Pavlov. Cond. change in total contacts2.42.64.71.4-1.5-1.31.61.6-1.41.61.70.31.81.81.8-1.8-1.62.2
Pavlov. Cond. index score0.30.40.90.7-0.8-0.70.70.8-0.40.60.70.70.60.50.5-0.4-0.40.9
Pavlov. Cond. latency score0.60.71.11.0-1.0-0.90.91.0-0.60.90.90.80.80.80.7-0.6-0.50.9
Pavlov. Cond. lever contacts0.80.91.51.2-1.2-1.11.11.2-0.71.01.01.10.80.80.7-0.6-0.41.1
Pavlov. Cond. magazine entry number0.10.10.40.10.1-0.0-0.1-0.1-0.0-0.1-0.20.2-0.3-0.2-0.30.20.5-0.7
Pavlov. Cond. intertrial magazine entries0.50.74.60.3-0.3-0.10.40.4-0.50.40.6-0.50.80.70.8-1.0-0.92.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.20.8-0.8-0.70.70.8-0.40.60.70.70.60.50.5-0.4-0.41.1
Pavlov. Cond. response bias0.50.71.40.8-0.9-0.80.90.9-0.70.80.90.70.80.70.8-0.6-0.51.2
Pavlov. Cond. lever latency3.75.18.3-2.92.82.8-2.7-2.72.7-2.5-2.4-2.2-2.0-2.0-1.81.40.4-0.9
Pavlov. Cond. magazine entry latency2.53.15.02.2-2.1-2.22.12.0-1.72.01.91.41.71.61.5-1.3-0.70.7
Pavlov. Cond. change in total contacts3.96.210.13.0-2.9-3.02.92.9-3.22.82.72.02.42.42.2-1.9-0.61.0
Pavlov. Cond. index score4.25.79.73.1-3.0-3.02.82.9-2.62.72.52.42.12.11.8-1.5-0.51.0
Pavlov. Cond. latency score3.54.78.32.9-2.7-2.72.62.6-2.32.52.32.21.91.91.6-1.3-0.30.9
Pavlov. Cond. lever contacts4.66.310.13.2-3.0-3.12.93.0-3.02.82.72.42.32.32.0-1.6-0.51.0
Pavlov. Cond. magazine entry number3.24.06.5-2.62.52.5-2.4-2.42.1-2.3-2.1-1.8-1.8-1.8-1.61.30.5-0.8
Pavlov. Cond. intertrial magazine entries1.52.34.3-2.12.02.1-1.8-2.01.3-1.7-1.5-2.1-1.1-1.1-0.80.4-0.10.1
Pavlov. Cond. lever-magazine prob. diff.4.25.59.63.1-2.9-3.02.82.9-2.62.72.52.42.12.01.8-1.4-0.40.9
Pavlov. Cond. response bias4.86.610.43.2-3.1-3.13.03.1-2.92.92.82.32.42.42.1-1.8-0.81.2
Time in closed arm before self-admin1.62.03.3-1.81.81.8-1.6-1.71.6-1.5-1.4-1.6-1.2-1.2-1.00.90.3-0.7
Time in closed arm after self-admin1.51.62.3-1.11.21.2-1.4-1.31.5-1.4-1.4-0.3-1.5-1.5-1.51.21.1-1.0
Time in open arm before self-admin0.70.71.20.9-0.9-0.90.91.1-1.10.90.90.80.80.80.7-0.6-0.40.7
Time in open arm after self-admin0.60.71.30.6-0.7-0.70.80.8-1.10.90.90.11.01.01.0-0.8-0.60.7
Bone: periosteal estimation0.10.21.30.6-0.7-0.50.40.5-0.10.20.21.1-0.1-0.1-0.20.30.60.7
Bone: periosteal perimeter0.10.20.60.4-0.4-0.40.20.3-0.60.20.10.8-0.1-0.0-0.10.20.80.1
Bone: post-yield work0.81.22.70.9-1.0-0.91.01.1-0.81.01.10.21.21.11.2-1.2-1.11.6
Progressive ratio test 1 active lever presses0.70.82.40.2-0.1-0.10.50.4-0.60.50.7-1.01.01.01.1-1.4-1.51.5
Progressive ratio test 1 breakpoint0.70.82.40.3-0.2-0.20.50.4-0.60.50.7-0.91.01.01.1-1.4-1.51.5
Progressive ratio test 1 inactive lever presses0.60.91.31.1-1.1-1.11.11.1-1.01.01.00.81.00.90.9-0.8-0.50.8
Progressive ratio test 2 active lever presses1.31.53.10.8-0.7-0.71.00.9-1.21.11.2-0.51.41.41.5-1.7-1.61.8
Progressive ratio test 2 breakpoint1.51.73.50.9-0.8-0.81.11.0-1.31.11.3-0.51.51.51.6-1.8-1.71.9
Progressive ratio test 2 inactive lever presses0.10.20.4-0.50.60.6-0.5-0.50.4-0.5-0.4-0.6-0.3-0.2-0.1-0.1-0.30.5
Incentive Sensitization - Responses1.82.54.01.2-1.1-1.11.41.4-1.61.51.7-0.21.91.92.0-2.0-2.02.0
Incentive Sensitization - Breakpoint1.72.23.41.2-1.1-1.11.41.3-1.51.41.6-0.11.71.71.8-1.8-1.71.8
Sum of active levers in priming session hrs 5-60.40.31.3-0.90.70.7-0.6-0.80.5-0.6-0.5-1.1-0.3-0.4-0.20.2-0.0-0.1
Progressive ratio0.20.30.91.0-0.5-0.50.60.7-0.80.60.60.60.50.50.4-0.6-0.00.4
Food seeking constrained by brief footshock0.30.41.01.0-0.6-0.60.70.7-0.90.70.60.80.40.50.4-0.50.20.0
Seeking ratio, punishment vs. effort0.00.00.10.0-0.2-0.20.20.1-0.10.20.20.10.20.20.2-0.1-0.1-0.0
Retroperitoneal fat weight2.611.038.80.6-0.7-0.81.81.5-1.52.22.8-3.43.93.84.3-4.6-6.24.8
Reaction time number correct1.12.02.81.5-1.4-1.41.51.5-1.61.61.60.41.71.61.6-1.4-1.21.1
Reaction time mean minus median0.92.16.70.5-0.6-0.71.00.8-0.71.11.4-1.41.81.71.9-2.0-2.61.7
Reaction time mean minus median AUC0.61.55.90.2-0.3-0.40.70.4-0.50.81.0-1.61.51.41.6-1.8-2.41.4
Reaction time num false alarms0.30.51.4-0.90.90.8-0.7-1.00.2-0.6-0.6-1.2-0.5-0.3-0.20.10.1-0.7
Reaction time num false alarms AUC0.10.20.7-0.60.50.4-0.4-0.7-0.1-0.4-0.4-0.7-0.4-0.2-0.20.10.2-0.8
Reaction time trials correct on left1.12.02.81.5-1.4-1.41.51.5-1.61.61.60.41.71.61.6-1.4-1.21.1
Reaction time trials on left1.01.92.61.4-1.3-1.31.51.4-1.61.51.50.41.61.61.5-1.4-1.21.0
Reaction time mean0.30.52.6-0.90.90.8-0.6-0.70.6-0.5-0.4-1.60.0-0.10.1-0.3-1.0-0.2
Reaction time mean AUC0.30.52.9-0.80.70.6-0.4-0.50.4-0.3-0.1-1.70.30.20.4-0.6-1.3-0.0
Median of all reaction times0.71.01.8-1.31.31.2-1.1-1.21.1-1.0-1.0-1.3-0.7-0.7-0.60.4-0.2-0.8
Reaction time omissions0.60.81.6-1.21.21.1-1.0-1.00.9-0.9-0.9-1.1-0.7-0.6-0.60.5-0.0-1.3
Reaction time false alarm rate0.81.11.9-1.31.21.1-1.2-1.40.8-1.1-1.1-1.0-1.1-0.9-0.90.70.7-1.1
Reaction time premature initiation rate2.02.86.01.3-1.4-1.51.71.6-2.51.81.90.32.02.02.0-1.7-1.30.9
Reaction time premature initiations2.74.78.81.9-1.9-2.02.32.1-3.02.42.50.52.62.62.5-2.2-1.71.3
Std. dev. reaction times0.50.94.1-0.40.30.10.1-0.2-0.30.30.5-2.01.01.01.2-1.4-2.00.5
Reaction time trials completed1.01.92.61.4-1.3-1.31.51.4-1.61.51.50.41.61.61.5-1.4-1.21.0
Reaction time trials AUC1.01.82.51.4-1.3-1.31.51.4-1.61.51.50.41.61.51.5-1.4-1.11.0
Run reversals in cocaine runway, females0.10.10.5-0.10.20.2-0.2-0.1-0.1-0.2-0.30.3-0.4-0.3-0.40.60.7-0.7
Run reversals in cocaine runway, males0.30.30.5-0.60.50.5-0.6-0.70.6-0.6-0.6-0.4-0.5-0.6-0.50.40.3-0.3
Latency to leave start box in cocaine runway0.40.52.2-0.50.40.4-0.2-0.30.5-0.10.1-1.20.40.40.6-0.7-1.51.0
Latency to leave start box in cocaine runway, F0.10.10.3-0.50.20.2-0.2-0.20.6-0.2-0.1-0.5-0.1-0.00.00.2-0.50.0
Latency to leave start box in cocaine runway, M0.60.52.0-0.20.40.4-0.0-0.20.10.00.3-1.20.60.50.7-1.0-1.41.4
Std. dev. time between licks in bursts0.20.30.6-0.70.70.7-0.7-0.80.5-0.6-0.6-0.8-0.5-0.5-0.40.20.1-0.1
Total sessions with >9 infusions0.20.21.0-0.50.50.5-0.4-0.40.3-0.3-0.2-1.00.0-0.00.1-0.4-0.70.6
Short access day 1 total inactive lever presses0.30.40.70.5-0.6-0.60.60.8-0.70.70.70.60.70.80.7-0.5-0.60.3
Short access day 10 total inactive lever presses0.92.12.81.3-1.4-1.41.51.5-1.21.61.60.41.71.71.6-1.5-1.51.3
Short access day 1 total infusions0.10.10.20.2-0.0-0.00.20.2-0.10.10.2-0.20.30.30.3-0.4-0.50.5
Short access day 10 total infusions0.30.40.6-0.60.60.6-0.7-0.70.6-0.7-0.7-0.6-0.7-0.7-0.60.30.3-0.1
Short access total infusions0.20.20.70.00.10.10.10.0-0.20.10.3-0.70.40.40.5-0.7-0.90.8
Short access day 1 locomotion0.00.00.10.1-0.0-0.0-0.00.00.2-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.10.3
Short access day 10 total locomotion1.42.63.7-1.91.91.9-1.9-1.91.9-1.9-1.8-1.4-1.6-1.6-1.51.20.5-0.6
Short access total locomotion0.40.51.6-0.90.90.9-0.8-0.80.7-0.7-0.6-1.3-0.3-0.3-0.1-0.2-0.60.6
One hour access (0.3 mA shock)1.71.93.01.3-1.2-1.21.41.2-1.61.31.50.01.51.51.6-1.6-1.21.7
Compulsive drug intake1.51.85.91.9-1.9-1.91.41.5-1.41.31.02.40.50.40.20.21.2-0.4
One hour access (shock baseline)0.50.83.4-1.11.11.1-0.8-0.90.6-0.7-0.4-1.8-0.1-0.00.2-0.5-1.10.9
Social response proportion1.01.12.0-1.31.31.4-1.2-1.21.2-1.2-1.0-1.4-0.9-0.8-0.60.4-0.10.2
Social responses0.50.71.2-1.01.11.1-1.0-0.91.0-1.0-0.9-0.9-0.8-0.7-0.60.40.10.1
Social time0.60.81.5-1.01.21.2-1.1-1.11.0-1.0-1.0-0.9-0.8-0.9-0.80.50.3-0.3
Soleus weight0.92.65.82.0-2.1-2.11.81.9-2.11.81.62.41.21.20.9-0.50.50.2
Bone: stiffness0.60.92.31.0-1.1-0.91.01.0-1.10.90.90.80.90.80.8-0.8-0.11.5
Tibialis anterior weight1.65.58.92.5-2.5-2.42.62.4-3.02.52.61.52.52.42.3-2.1-1.21.8
Time to tail flick, vehicle, before self-admin0.20.20.40.6-0.6-0.60.40.2-0.10.30.30.30.10.20.2-0.40.10.6
Time to tail flick, vehicle, after self-admin0.30.41.71.0-0.9-0.90.70.7-0.20.60.41.30.20.0-0.10.20.5-0.2
Time to tail flick, test, before self-admin0.90.91.2-1.00.90.9-1.1-1.10.8-1.1-1.1-0.3-1.1-1.1-1.10.91.1-0.8
Time to tail flick, test, after self-admin1.11.14.2-1.41.61.6-1.1-1.00.9-0.9-0.7-2.0-0.2-0.20.1-0.4-1.20.4
Delta time to tail flick, vehicle, before/after SA0.30.21.00.5-0.5-0.50.40.6-0.40.40.21.00.20.0-0.10.40.5-0.6
Delta time to tail flick, test, before/after SA1.91.97.10.3-0.2-0.20.80.8-0.81.01.3-1.21.71.71.9-1.9-2.71.6
Tibia length0.82.33.21.6-1.7-1.71.71.8-1.51.71.70.71.61.71.6-1.3-1.10.9
Ambulatory time before self-admin0.20.42.1-0.20.00.0-0.2-0.10.3-0.2-0.40.5-0.5-0.5-0.61.01.0-1.4
Ambulatory time after self-admin0.91.12.3-1.21.01.0-1.0-1.00.9-1.0-1.1-0.5-1.0-1.0-1.01.31.0-1.5
Bone: tissue strength0.60.62.1-0.20.20.30.1-0.0-0.00.20.4-1.40.70.70.9-1.1-1.41.4
Total heroin consumption0.60.72.70.7-0.8-0.80.30.4-0.30.2-0.11.4-0.4-0.5-0.70.91.6-1.1
Bone: trabecular number0.10.20.6-0.50.40.6-0.5-0.40.4-0.5-0.4-0.0-0.4-0.4-0.30.20.10.8
Bone: trabecular spacing0.91.22.81.2-1.2-1.31.31.2-1.71.31.20.81.11.11.0-0.8-0.3-0.4
Bone: trabecular thickness1.31.62.7-1.51.41.5-1.5-1.41.7-1.5-1.4-0.9-1.3-1.3-1.21.00.5-0.4
Bone: trabecular tissue density1.72.44.8-0.81.00.9-1.2-1.21.5-1.3-1.60.7-1.8-1.8-2.02.22.1-2.2
Water consumed over 24 hours0.10.20.50.4-0.4-0.40.40.5-0.70.40.40.40.40.40.4-0.3-0.00.1
Number of responses in last shaping day0.40.41.30.8-0.9-0.90.70.7-0.60.60.51.10.30.30.2-0.00.4-0.3