Tnfaip2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Tnfaip2 0.22 0.3 6.2e-03 0.01 0.01 0 0.01 2.4e-02 2.5e-02 7.3e-02 2.6e-02
2 pVTA gene expression Tnfaip2 0.1 0.12 2.0e-03 0.05 0.05 0.05 0.05 2.3e-03 3.2e-03 3.2e-03 3.5e-03
3 PL gene expression Tnfaip2 0.02 0.02 6.8e-03 0.01 0.01 0 0.01 1.6e-02 9.5e-03 8.1e-02 3.0e-02
4 LHb gene expression Tnfaip2 0.13 0.12 7.0e-03 0.02 0.03 0.03 0.02 1.2e-01 6.9e-02 8.5e-02 1.1e-01
5 Brain gene expression Tnfaip2 0.07 0.05 4.7e-06 0.04 0.05 0.04 0.04 2.2e-04 1.3e-05 1.3e-04 5.6e-05
6 IL gene expression Tnfaip2 0.15 0.13 1.6e-03 0.08 0.09 0.1 0.08 5.5e-03 3.2e-03 2.7e-03 5.5e-03
7 Adipose gene expression Tnfaip2 0.19 0.1 0.0e+00 0.21 0.21 0.21 0.21 4.0e-23 7.2e-23 8.8e-23 7.4e-23
8 Adipose mRNA stability Tnfaip2 0.05 0.08 2.4e-03 0.02 0.01 0.01 0.01 5.9e-03 2.5e-02 4.2e-02 1.2e-02
9 NAcc mRNA stability Tnfaip2 0.04 0.04 4.0e-05 0.05 0.04 0.04 0.04 4.7e-06 2.2e-05 5.8e-06 9.9e-06
10 Liver mRNA stability Tnfaip2 0.03 0.03 9.1e-04 0.01 0.01 0.01 0.01 6.9e-03 1.5e-02 8.9e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.20.8-0.3-0.50.20.20.30.8-0.2-0.2-0.3-0.9
Area under the delay curve0.60.64.3-0.2-0.40.40.40.3-2.1-0.6-0.60.70.4
BMI with tail2.68.423.0-2.8-2.62.92.92.8-4.8-3.0-3.0-1.5-0.5
BMI without tail0.71.57.2-1.3-0.71.11.00.9-2.7-0.8-0.80.11.0
Body weight0.20.93.20.60.5-0.6-0.6-0.6-1.10.50.51.51.8
Weight adjusted by age0.10.10.40.10.0-0.1-0.1-0.1-0.60.10.10.50.3
Bone surface0.10.10.7-0.3-0.20.10.10.10.9-0.1-0.1-0.0-0.4
Bone volume0.10.21.1-0.3-0.30.20.10.21.0-0.1-0.1-0.2-0.7
Breakpoint value in progressive ratio session0.10.10.3-0.1-0.20.00.00.00.6-0.3-0.3-0.4-0.4
Number of licking bursts0.30.31.70.20.6-0.3-0.4-0.4-0.30.60.60.41.3
Context. condit. distance diff. score1.61.94.11.51.5-1.5-1.5-1.52.01.21.20.90.5
Locomotion velocity, session 10.60.62.80.40.6-0.6-0.6-0.61.70.60.60.70.4
Locomotion distance, session 10.50.62.8-0.8-0.80.60.60.61.7-0.6-0.6-0.8-0.2
Locomotion velocity, session 20.20.21.10.1-0.60.10.20.21.1-0.3-0.3-0.4-0.1
Locomotion distance, session 20.30.40.6-0.7-0.80.60.60.60.8-0.6-0.6-0.8-0.1
Locomotion velocity, session 30.40.52.0-0.4-0.50.40.50.50.5-0.6-0.6-1.0-1.4
Locomotion distance, session 30.10.10.60.00.2-0.2-0.2-0.10.70.20.2-0.1-0.8
Stereotopy head waving bouts, day 30.10.10.30.30.3-0.4-0.4-0.40.60.30.30.10.4
Stereotopy head waving duration, day 30.30.31.60.40.5-0.5-0.5-0.51.30.40.40.20.5
Locomotion velocity, session 70.80.94.3-0.4-0.70.60.70.70.4-0.8-0.8-1.3-2.1
Locomotion distance, session 71.01.34.1-0.9-0.91.01.01.1-0.1-1.1-1.1-1.4-2.0
Stereotopy head waving bouts, day 70.81.01.31.01.1-1.0-1.0-1.01.11.11.10.9-0.0
Stereotopy head waving duration, day 70.30.30.40.60.6-0.6-0.5-0.50.60.60.60.60.1
Locomotion velocity, session 80.20.21.10.50.2-0.4-0.4-0.41.00.30.30.00.0
Locomotion distance, session 80.20.32.4-0.2-0.10.10.10.11.6-0.2-0.2-0.7-0.7
Degree of sensitization distance0.20.20.3-0.2-0.40.40.40.4-0.6-0.4-0.4-0.4-0.5
Degree of sensitization stereotypy0.30.30.70.40.6-0.5-0.5-0.40.80.60.60.4-0.4
Conditioned locomotion1.11.21.71.31.0-1.2-1.1-1.11.31.31.30.90.1
Cocaine response after cond. corrected0.20.30.6-0.8-0.60.70.70.7-0.2-0.2-0.2-0.5-0.1
Cocaine response after cond. not corrected1.41.52.1-1.4-1.41.41.41.4-1.0-1.2-1.2-1.2-0.5
Cocaine response before conditioning2.93.54.9-1.7-1.91.81.81.8-2.0-2.2-2.2-1.9-1.5
Saline control response0.30.42.1-0.5-0.50.50.50.50.3-0.3-0.3-0.7-1.5
Bone: connectivity density0.10.10.60.2-0.1-0.2-0.2-0.20.70.10.10.2-0.2
Bone: cortical apparent density7.29.612.23.53.1-3.4-3.3-3.32.53.13.12.92.6
Bone: cortical area1.42.13.11.11.5-1.4-1.5-1.51.81.61.61.40.3
Bone: cortical porosity0.20.21.00.0-0.2-0.00.00.10.80.10.1-0.4-1.0
Bone: cortical porosity0.40.41.5-0.5-0.60.50.50.50.5-0.3-0.3-0.8-1.2
Bone: cortical thickness1.42.37.11.11.4-1.5-1.5-1.42.71.61.61.0-0.1
Bone: cortical thickness0.91.11.60.91.1-1.1-1.2-1.11.31.21.20.70.0
Bone: cortical tissue density7.49.712.43.53.1-3.4-3.3-3.32.53.13.12.92.7
Condit. Reinf. active minus inactive responses0.50.61.3-0.9-0.80.80.70.7-1.1-0.7-0.7-0.6-0.4
Condit. Reinf. active-inactive response ratio2.32.52.9-1.7-1.61.61.61.6-1.6-1.6-1.6-1.4-1.2
Condit. Reinf. active responses0.20.20.3-0.5-0.50.50.50.5-0.1-0.5-0.5-0.6-0.4
Condit. Reinf. inactive responses1.92.25.01.61.4-1.5-1.5-1.52.21.41.41.11.1
Incentive salience index mean0.40.50.7-0.8-0.80.70.70.7-0.7-0.8-0.8-0.6-0.4
Condit. Reinf. lever presses0.20.20.5-0.3-0.70.40.40.40.5-0.6-0.6-0.4-0.4
Condit. Reinf. active minus inactive responses0.40.51.40.70.6-0.6-0.6-0.60.80.50.50.41.2
Condit. Reinf. active-inactive response ratio0.40.40.80.60.7-0.6-0.6-0.60.20.50.50.60.9
Condit. Reinf. active responses0.00.10.3-0.0-0.20.10.10.10.2-0.1-0.1-0.30.6
Condit. Reinf. inactive responses0.60.71.0-0.8-1.00.90.90.9-0.7-0.6-0.6-1.0-0.6
Condit. Reinf. lever presses1.52.02.7-1.5-1.61.51.51.5-0.4-1.5-1.5-1.6-0.9
Condit. Reinf. lever reinforcers received0.00.00.2-0.0-0.20.20.20.20.1-0.1-0.1-0.30.5
Conditioned reinforcement - actives1.91.93.11.51.2-1.4-1.4-1.41.81.51.51.30.6
Conditioned reinforcement - inactives0.40.51.80.60.6-0.6-0.6-0.61.30.70.70.30.2
Conditioned locomotion1.01.22.6-0.9-1.50.91.01.00.2-0.9-0.9-1.4-1.6
Patch foraging indifference point 0 sec2.54.06.02.52.1-2.2-2.1-2.11.22.12.12.01.2
Patch foraging indifference point AUC2.32.73.71.81.4-1.7-1.7-1.71.71.41.41.51.9
Delay disc. indifference point, 0s delay0.10.10.30.3-0.0-0.2-0.2-0.2-0.60.00.00.60.5
Delay disc. indifference point, 16s delay0.30.31.4-0.2-0.20.20.30.2-1.2-0.6-0.60.40.5
Delay disc. indifference point, 2s delay0.10.10.2-0.3-0.30.30.20.2-0.5-0.5-0.50.20.3
Delay disc. indifference point, 24s delay0.30.32.2-0.30.10.20.10.1-1.5-0.1-0.10.80.5
Delay disc. indifference point, 4s delay0.70.74.40.40.1-0.2-0.2-0.2-2.10.10.11.20.9
Delay disc. indifference point, 8s delay1.01.06.8-0.4-0.60.60.60.6-2.6-0.8-0.80.50.2
Indifference point function ln k0.60.81.40.90.8-0.8-0.9-0.80.81.21.20.90.2
Indifference point function log k0.60.81.40.90.8-0.8-0.9-0.80.81.21.20.90.2
Patch foraging total patch changes 0 sec2.74.36.82.62.2-2.3-2.2-2.21.32.12.12.11.4
Patch foraging total patch changes 12 sec2.73.55.42.31.8-2.1-2.0-2.01.61.71.71.71.7
Patch foraging total patch changes 18 sec0.91.22.81.60.6-1.3-1.1-1.11.70.90.90.60.5
Patch foraging total patch changes 24 sec0.10.20.50.50.0-0.3-0.3-0.3-0.5-0.1-0.10.50.7
Patch foraging total patch changes 6 sec1.72.54.71.91.5-1.6-1.5-1.60.11.31.32.02.2
Patch foraging time to switch 0 sec10.416.117.5-4.2-4.14.14.14.1-4.1-4.2-4.2-3.5-3.5
Patch foraging water rate 0 sec16.927.032.45.75.4-5.5-5.4-5.54.55.25.25.04.5
Patch foraging water rate 12 sec9.614.720.33.84.2-3.7-3.8-3.82.13.83.84.24.5
Patch foraging water rate 18 sec4.96.69.22.53.0-2.6-2.7-2.61.62.72.72.82.1
Patch foraging water rate 24 sec3.95.47.12.32.7-2.4-2.5-2.51.52.32.32.52.2
Patch foraging water rate 6 sec4.46.47.62.72.6-2.6-2.6-2.62.62.72.72.12.0
Seeking ratio, delayed vs. immediate footshock0.50.62.60.50.4-0.6-0.6-0.61.60.20.20.70.9
Distance traveled before self-admin0.10.10.5-0.1-0.10.20.10.1-0.7-0.1-0.10.10.5
Distance traveled after self-admin0.50.61.00.71.0-0.7-0.8-0.80.60.70.70.60.8
Extensor digitorum longus weight5.622.123.94.84.6-4.8-4.9-4.93.84.84.84.64.8
Bone: elastic displacement0.60.71.10.80.8-0.9-0.9-0.90.71.01.00.40.2
Bone: elastic work0.20.30.90.30.5-0.5-0.6-0.50.90.70.70.20.1
Bone: endosteal estimation0.20.41.7-0.8-0.40.60.60.5-1.3-0.6-0.60.10.2
Bone: endosteal perimeter0.10.20.6-0.20.4-0.0-0.1-0.1-0.50.20.20.80.6
Epididymis fat weight4.510.414.4-3.3-3.13.33.33.3-3.8-3.3-3.3-2.8-2.7
Delta time in closed arm before/after self-admin0.10.00.2-0.3-0.00.20.20.2-0.50.10.1-0.1-0.2
Delta time in open arm before/after self-admin0.60.61.50.70.4-0.6-0.7-0.7-0.50.60.61.21.1
Diff in mean of infusions in LGA sessions0.30.31.40.2-0.3-0.2-0.1-0.11.20.60.6-0.4-0.6
Delay discount exponential model param0.60.64.40.20.3-0.3-0.3-0.32.10.60.6-0.8-0.5
Extinction: sum of active levers before priming0.10.10.6-0.0-0.10.00.00.10.8-0.0-0.0-0.7-0.3
Active lever presses in extinction session 61.21.11.51.11.0-1.1-1.1-1.11.21.01.00.90.9
Bone: final force0.50.81.50.50.8-0.8-0.9-0.81.21.01.00.9-0.3
Bone: final moment0.61.02.10.51.0-0.9-1.0-0.91.41.11.11.0-0.2
Food consumed during 24 hour testing period0.10.10.30.30.2-0.4-0.4-0.40.30.20.20.30.5
Glucose0.71.01.71.31.1-1.1-1.1-1.11.00.80.81.20.4
Heart weight0.00.00.20.1-0.20.10.10.1-0.20.10.1-0.4-0.0
Delay discount hyperbolic model param0.60.64.00.20.4-0.3-0.3-0.32.00.60.6-0.8-0.4
Intermittent access intake day 1-15 change1.51.53.0-1.2-1.31.11.21.20.3-1.1-1.1-1.7-1.5
Intermittent access intake escalation1.81.73.6-1.3-1.41.21.21.30.4-1.3-1.3-1.9-1.6
Intermittent access intake escalation 20.20.20.7-0.4-0.30.30.30.30.8-0.2-0.2-0.7-0.7
Intermitt. access day 1 inactive lever presses2.32.53.11.81.6-1.7-1.7-1.71.71.61.61.31.1
Intermitt. access day 15 inactive lever presses0.80.91.11.01.0-1.0-0.9-0.91.01.11.10.80.4
Intermitt. access escalation Index0.70.62.40.60.6-0.5-0.5-0.5-1.10.20.21.21.6
Intermittent access day 1 total infusions0.40.51.0-0.6-0.80.70.70.7-1.0-0.7-0.7-0.2-0.3
Intermittent access day 15 total infusions1.82.02.6-1.4-1.61.51.51.5-0.7-1.6-1.6-1.5-1.2
Intermittent access terminal intake (last 3 days)1.92.02.9-1.5-1.71.61.61.6-0.7-1.3-1.3-1.5-1.3
Intermittent access total infusions0.80.81.2-0.8-1.11.01.01.0-0.7-1.0-1.0-0.8-0.8
Intermittent access day 1 locomotion1.01.01.9-1.0-1.41.01.11.0-0.8-1.0-1.0-0.9-0.9
Intermittent access day 15 total locomotion0.40.51.0-0.6-1.00.60.60.60.3-0.6-0.6-0.9-0.7
Intermittent access total locomotion0.60.71.3-0.7-1.10.70.70.80.1-0.8-0.8-1.0-0.9
Intermittent access standard deviation3.33.54.2-2.0-2.11.92.02.0-0.8-1.8-1.8-2.0-1.9
Left kidney weight0.61.62.21.41.1-1.2-1.2-1.20.21.51.51.21.5
Right kidney weight0.30.81.40.91.2-0.8-0.8-0.8-0.11.11.11.01.1
Cocaine induced anxiety2.93.44.21.92.1-1.9-1.9-1.91.31.91.91.81.8
Post-drug Anxiety2.42.63.21.71.8-1.7-1.7-1.70.91.71.71.71.5
Baseline Anxiety1.51.62.1-1.3-1.51.31.31.3-1.1-1.3-1.3-1.1-1.2
Tail length3.39.811.53.03.0-3.1-3.1-3.13.03.43.43.03.1
Length with tail3.713.715.73.93.5-3.9-3.9-3.93.54.04.03.43.0
Length without tail1.32.84.82.21.3-2.0-1.8-1.81.91.71.71.20.8
Times rat made contact with spout0.20.20.40.70.5-0.6-0.5-0.60.40.20.20.60.1
Lifetime Intake0.40.50.8-0.5-0.90.70.70.7-0.2-0.7-0.7-0.7-0.8
Liver weight, left3.76.09.92.22.4-2.3-2.4-2.41.42.62.62.43.1
Liver weight, right0.10.10.70.20.1-0.0-0.0-0.1-0.80.20.20.50.7
Locomotor activity0.00.10.20.50.0-0.3-0.2-0.2-0.20.20.2-0.0-0.3
Locomotor testing distance0.20.30.70.80.3-0.7-0.6-0.50.80.50.5-0.1-0.5
Locomotor testing rearing1.93.05.6-1.2-1.91.51.61.6-0.2-1.7-1.7-2.4-2.4
Locomotion in novel chamber5.26.48.72.62.6-2.5-2.6-2.60.92.62.62.73.0
Locomotion in novel chamber post-restriction0.10.10.2-0.50.00.20.10.1-0.40.10.10.40.5
Fecal boli incidents, locomotor time 11.21.32.6-1.6-1.21.31.21.2-1.2-1.2-1.2-0.60.0
Change in fecal boli incidents, locomotor task0.20.20.60.50.4-0.3-0.3-0.3-0.80.40.40.20.4
Time >=10cm from walls, locomotor time 10.60.61.7-0.7-0.80.70.70.7-1.3-0.7-0.7-0.2-0.5
Bouts of movement, locomotor time 10.91.01.5-1.2-0.91.11.01.0-0.5-1.1-1.1-0.9-1.0
Total resting periods, locomotor time 11.01.01.5-1.2-0.91.11.01.0-0.7-1.1-1.1-1.0-1.0
Rest time, locomotor task time 10.50.51.30.50.9-0.5-0.5-0.6-0.40.70.70.81.1
Distance moved, locomotor task time 10.90.92.6-0.4-1.00.60.70.70.7-1.0-1.0-1.3-1.6
Vertical activity count, locomotor time 10.40.51.90.90.3-0.8-0.7-0.71.40.30.30.2-0.1
Time >=10cm from walls, locomotor time 20.60.72.20.80.3-0.8-0.8-0.81.50.90.90.5-0.1
Bouts of movement, locomotor time 22.42.54.21.32.0-1.5-1.6-1.61.21.61.61.71.6
Total resting periods, locomotor time 21.92.03.91.22.0-1.3-1.4-1.40.41.41.41.81.6
Rest time, locomotor task time 21.01.12.50.61.6-0.7-0.7-0.7-1.50.80.81.21.4
Distance moved, locomotor task time 21.11.33.3-0.3-1.40.50.60.71.7-0.9-0.9-1.5-1.8
Vertical activity count, locomotor time 21.11.28.80.80.0-0.8-0.7-0.73.00.60.6-0.3-0.6
Light reinforcement 10.10.10.3-0.10.10.20.20.2-0.5-0.5-0.5-0.1-0.3
Light reinforcement 21.21.62.5-1.6-1.01.31.21.3-1.2-1.2-1.2-1.0-1.6
Bone: marrow area0.20.41.6-0.7-0.40.60.50.5-1.3-0.5-0.50.20.2
Bone: maximum diameter0.20.30.70.10.7-0.4-0.5-0.5-0.10.60.60.80.8
Bone: maximum force0.50.81.40.60.9-0.9-0.9-0.91.21.01.01.0-0.4
Bone: maximum moment0.50.81.80.50.9-0.8-0.9-0.81.31.01.00.9-0.4
Mean time between licks in bursts0.91.32.2-1.2-1.51.21.11.1-1.0-1.0-1.0-1.3-0.9
Mean num. licks in bursts0.30.31.80.1-0.4-0.00.10.10.9-0.4-0.4-0.2-1.3
Cd content in liver0.70.83.20.50.8-0.7-0.8-0.80.20.80.80.81.8
Co content in liver0.91.12.71.00.8-1.0-1.0-1.01.71.21.20.60.8
Cu content in liver1.11.34.7-1.2-1.11.11.11.1-2.2-1.0-1.0-0.9-0.2
Fe content in liver0.20.21.3-0.3-0.30.30.30.3-1.1-0.3-0.3-0.0-0.4
K content in liver0.10.10.10.30.2-0.3-0.2-0.20.40.30.3-0.00.1
Mg content in liver0.10.10.20.4-0.0-0.2-0.1-0.20.50.10.1-0.20.2
Mn content in liver0.20.31.20.2-0.0-0.10.00.01.0-0.2-0.2-0.6-1.1
Na content in liver0.00.00.1-0.2-0.00.10.10.10.3-0.2-0.2-0.3-0.1
Rb content in liver0.50.61.01.00.6-0.8-0.8-0.80.00.90.90.80.6
Se content in liver0.30.31.2-0.60.20.20.10.1-1.10.00.00.61.0
Sr content in liver0.50.41.00.40.7-0.6-0.7-0.70.10.70.70.81.0
Zn content in liver0.40.41.30.50.6-0.5-0.5-0.50.80.50.50.51.1
Bone: minimum diameter0.71.22.01.01.2-1.1-1.2-1.20.71.21.21.40.7
Time in familiar zone, hab. session 11.00.92.0-0.5-1.00.80.90.90.6-1.0-1.0-1.4-1.1
Time in novel zone, hab. session 10.40.42.7-0.40.30.10.00.0-1.70.00.00.60.5
Total zone transitions, hab. session 10.50.71.2-1.0-0.80.80.80.80.3-0.9-0.9-1.1-0.7
Total locomotion distance, hab. session 10.10.10.60.10.2-0.1-0.2-0.10.80.10.1-0.2-0.1
Locomotion velocity, hab. session 10.40.62.00.70.8-0.8-0.8-0.71.40.70.70.30.4
Time in familiar zone, hab. session 21.11.12.0-0.5-1.20.91.01.0-0.5-1.2-1.2-1.4-1.4
Time in novel zone, hab. session 20.20.21.1-0.40.30.0-0.1-0.1-0.40.30.30.51.1
Total zone transitions, hab. session 20.50.71.2-1.1-0.90.90.80.80.4-0.8-0.8-1.1-0.5
Total locomotion distance, hab. session 20.60.72.20.50.9-0.8-0.8-0.81.50.90.90.40.6
Locomotion velocity, hab. session 20.81.03.30.71.0-0.9-1.0-1.01.81.01.00.50.6
Novel to familiar place preference ratio0.20.20.4-0.7-0.40.50.50.5-0.7-0.3-0.3-0.3-0.5
Novelty place preference0.10.20.4-0.5-0.30.40.40.4-0.6-0.3-0.3-0.2-0.4
Time in novel zone, NPP test0.10.10.4-0.5-0.20.30.30.3-0.6-0.2-0.2-0.1-0.3
Total zone transitions, NPP test0.20.21.3-0.6-0.30.30.30.31.1-0.2-0.2-0.40.3
Total locomotion distance, NPP test0.10.21.0-0.10.5-0.3-0.3-0.31.00.50.50.10.0
Locomotion velocity, NPP test0.20.31.30.00.5-0.3-0.4-0.41.10.50.50.10.2
Intraocular pressure0.10.10.4-0.3-0.30.20.30.3-0.1-0.4-0.4-0.0-0.7
Delta distance traveled before/after self-admin0.30.31.60.10.3-0.2-0.2-0.11.30.20.2-0.5-0.8
Delta ambulatory time before/after self-admin0.60.62.90.70.8-0.8-0.8-0.71.70.50.50.1-0.2
Parametrial fat weight0.10.21.2-0.10.1-0.0-0.1-0.1-1.10.00.00.70.8
Pavlov. Cond. lever latency0.60.81.21.01.1-0.9-0.9-0.90.51.01.00.80.4
Pavlov. Cond. magazine entry latency0.70.82.1-0.8-1.00.80.80.80.1-0.9-0.9-1.0-1.5
Pavlov. Cond. change in total contacts0.40.40.7-0.5-0.80.60.60.60.4-0.8-0.8-0.8-0.5
Pavlov. Cond. index score0.81.11.5-1.2-1.21.11.11.1-0.4-1.1-1.1-1.1-0.9
Pavlov. Cond. latency score0.50.71.1-1.0-1.00.90.80.8-0.3-0.9-0.9-0.9-0.5
Pavlov. Cond. lever contacts0.80.91.5-1.1-1.21.01.01.0-0.4-1.0-1.0-0.9-0.6
Pavlov. Cond. magazine entry number1.11.41.81.21.3-1.2-1.2-1.20.51.21.21.21.3
Pavlov. Cond. intertrial magazine entries4.95.96.72.52.6-2.6-2.6-2.61.82.62.62.41.9
Pavlov. Cond. lever-magazine prob. diff.0.60.71.0-1.0-1.00.90.80.9-0.1-0.9-0.9-0.8-0.9
Pavlov. Cond. response bias1.31.62.7-1.2-1.41.21.21.3-0.2-1.3-1.3-1.3-1.6
Pavlov. Cond. lever latency2.02.74.21.81.8-1.8-1.7-1.7-0.21.61.62.11.4
Pavlov. Cond. magazine entry latency4.75.46.0-2.4-2.32.52.52.5-2.3-2.4-2.4-2.1-2.0
Pavlov. Cond. change in total contacts3.75.16.3-2.4-2.42.52.52.5-1.5-2.2-2.2-2.5-1.9
Pavlov. Cond. index score4.76.07.0-2.6-2.52.72.72.6-1.5-2.6-2.6-2.6-1.9
Pavlov. Cond. latency score4.65.76.6-2.5-2.52.62.62.6-1.4-2.5-2.5-2.5-1.9
Pavlov. Cond. lever contacts2.53.45.2-2.2-2.02.12.02.0-0.0-1.8-1.8-2.3-1.1
Pavlov. Cond. magazine entry number4.04.95.62.22.3-2.3-2.4-2.32.22.22.22.21.7
Pavlov. Cond. intertrial magazine entries4.35.67.72.82.3-2.6-2.5-2.52.52.32.32.11.5
Pavlov. Cond. lever-magazine prob. diff.5.36.87.9-2.7-2.72.82.82.8-1.7-2.7-2.7-2.7-2.2
Pavlov. Cond. response bias3.54.76.5-2.4-2.32.42.42.4-0.9-2.1-2.1-2.5-1.4
Time in closed arm before self-admin2.73.13.7-1.9-1.81.91.81.8-1.7-1.9-1.9-1.5-1.3
Time in closed arm after self-admin1.41.52.0-1.3-1.21.41.31.3-1.4-1.1-1.1-0.9-1.0
Time in open arm before self-admin4.75.06.22.52.2-2.3-2.3-2.31.72.32.32.12.2
Time in open arm after self-admin2.83.14.42.01.6-1.8-1.8-1.90.51.71.72.12.0
Bone: periosteal estimation0.20.41.20.20.7-0.6-0.7-0.60.20.70.71.10.6
Bone: periosteal perimeter0.20.30.90.10.7-0.4-0.5-0.50.00.70.70.90.4
Bone: post-yield work1.01.41.81.31.4-1.3-1.2-1.20.91.31.31.20.5
Progressive ratio test 1 active lever presses0.10.10.3-0.1-0.40.20.20.20.3-0.1-0.1-0.3-0.5
Progressive ratio test 1 breakpoint0.20.20.4-0.2-0.60.40.40.40.1-0.3-0.3-0.4-0.7
Progressive ratio test 1 inactive lever presses2.62.95.81.81.6-1.8-1.7-1.72.41.81.81.20.8
Progressive ratio test 2 active lever presses0.00.00.10.0-0.20.10.20.20.3-0.1-0.1-0.3-0.2
Progressive ratio test 2 breakpoint0.00.00.10.0-0.20.10.10.10.2-0.1-0.1-0.2-0.2
Progressive ratio test 2 inactive lever presses0.80.91.61.10.8-1.0-0.9-0.91.20.90.90.70.8
Incentive Sensitization - Responses0.00.00.1-0.00.00.10.10.1-0.2-0.2-0.20.10.2
Incentive Sensitization - Breakpoint0.00.00.10.10.10.00.00.0-0.1-0.1-0.10.10.3
Sum of active levers in priming session hrs 5-60.50.51.1-0.4-0.60.40.40.40.2-1.1-1.1-0.7-1.0
Progressive ratio0.40.50.90.60.6-0.7-0.7-0.71.00.50.50.70.8
Food seeking constrained by brief footshock2.12.66.21.41.6-1.6-1.6-1.62.51.71.71.30.6
Seeking ratio, punishment vs. effort0.20.20.80.30.5-0.4-0.3-0.30.90.50.5-0.0-0.6
Retroperitoneal fat weight0.20.84.4-0.9-0.50.80.80.7-2.1-0.7-0.70.00.2
Reaction time number correct2.43.45.62.41.7-2.0-1.9-1.91.31.91.91.61.5
Reaction time mean minus median0.20.21.4-0.5-0.10.40.30.3-1.20.00.00.40.2
Reaction time mean minus median AUC0.10.21.1-0.5-0.00.30.30.3-1.10.10.10.3-0.1
Reaction time num false alarms0.50.71.51.21.0-1.0-0.9-0.9-0.10.70.70.70.7
Reaction time num false alarms AUC1.01.42.31.51.3-1.3-1.3-1.30.21.11.11.00.9
Reaction time trials correct on left2.43.45.62.41.7-2.0-1.9-1.91.31.91.91.61.5
Reaction time trials on left2.43.45.62.41.7-2.0-1.9-1.91.32.02.01.61.5
Reaction time mean0.71.01.5-1.2-1.11.11.11.1-1.2-0.6-0.6-0.9-0.4
Reaction time mean AUC0.40.61.3-1.0-0.80.90.90.9-1.1-0.4-0.4-0.6-0.3
Median of all reaction times0.50.71.0-1.0-1.00.90.90.9-0.8-0.5-0.5-1.0-0.4
Reaction time omissions1.31.83.51.01.3-1.1-1.2-1.20.71.51.51.51.9
Reaction time false alarm rate0.10.10.30.30.4-0.3-0.3-0.3-0.60.20.20.30.3
Reaction time premature initiation rate0.70.91.31.01.0-1.0-1.0-1.01.20.80.80.90.9
Reaction time premature initiations2.12.94.02.01.6-1.8-1.7-1.71.91.71.71.51.4
Std. dev. reaction times0.30.41.9-0.8-0.30.70.60.6-1.4-0.1-0.10.10.2
Reaction time trials completed2.43.45.62.41.7-2.0-1.9-1.91.32.02.01.61.5
Reaction time trials AUC2.63.76.02.51.8-2.1-2.0-2.01.42.02.01.71.6
Run reversals in cocaine runway, females1.01.01.6-0.9-1.01.01.11.1-1.3-1.0-1.0-0.8-0.9
Run reversals in cocaine runway, males0.90.91.31.00.9-1.0-1.0-1.00.91.21.20.70.3
Latency to leave start box in cocaine runway0.20.20.4-0.2-0.30.40.50.5-0.5-0.6-0.6-0.6-0.4
Latency to leave start box in cocaine runway, F0.30.30.5-0.1-0.60.40.50.5-0.3-0.7-0.7-0.7-0.5
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.20.30.30.3-0.5-0.3-0.3-0.2-0.2
Std. dev. time between licks in bursts0.70.91.9-1.0-1.30.90.90.9-0.1-0.6-0.6-1.1-1.4
Total sessions with >9 infusions0.50.51.9-0.1-0.80.30.30.31.4-0.4-0.4-1.0-1.0
Short access day 1 total inactive lever presses0.10.10.3-0.1-0.10.30.30.3-0.1-0.4-0.4-0.5-0.4
Short access day 10 total inactive lever presses0.40.50.90.70.8-0.6-0.7-0.7-0.10.60.60.90.9
Short access day 1 total infusions0.20.20.30.50.3-0.4-0.4-0.40.50.20.20.50.4
Short access day 10 total infusions0.50.61.0-0.6-1.00.70.80.8-0.8-0.7-0.7-0.4-0.9
Short access total infusions0.30.30.6-0.4-0.80.50.60.6-0.0-0.6-0.6-0.5-0.7
Short access day 1 locomotion0.91.02.2-0.7-1.50.91.01.0-0.5-0.9-0.9-1.1-1.2
Short access day 10 total locomotion0.80.92.2-0.8-1.50.80.90.9-0.4-0.9-0.9-1.3-0.9
Short access total locomotion0.20.31.1-0.2-1.10.30.30.30.1-0.4-0.4-0.7-0.6
One hour access (0.3 mA shock)0.10.10.50.40.0-0.3-0.2-0.20.70.30.30.0-0.1
Compulsive drug intake0.00.00.1-0.10.20.10.10.1-0.2-0.2-0.20.00.1
One hour access (shock baseline)0.10.10.2-0.1-0.50.10.20.20.4-0.2-0.2-0.4-0.5
Social response proportion0.20.30.60.70.6-0.5-0.4-0.5-0.10.40.40.50.8
Social responses0.10.20.5-0.2-0.10.20.30.30.4-0.6-0.6-0.5-0.7
Social time0.91.11.61.01.2-1.0-1.0-1.00.71.21.21.11.1
Soleus weight0.00.10.3-0.2-0.40.20.20.20.5-0.1-0.1-0.5-0.4
Bone: stiffness1.82.94.11.41.9-1.7-1.8-1.71.71.91.92.00.5
Tibialis anterior weight0.31.11.61.00.8-1.0-1.0-1.11.01.11.11.01.3
Time to tail flick, vehicle, before self-admin0.60.71.10.71.0-0.8-0.9-0.90.40.60.61.11.0
Time to tail flick, vehicle, after self-admin0.30.31.0-0.4-0.70.50.50.50.3-0.5-0.5-0.7-1.0
Time to tail flick, test, before self-admin0.20.21.20.3-0.0-0.2-0.2-0.21.10.20.2-0.20.0
Time to tail flick, test, after self-admin1.61.72.41.41.3-1.3-1.3-1.30.31.41.41.51.1
Delta time to tail flick, vehicle, before/after SA0.40.41.5-0.2-0.70.30.40.40.6-0.2-0.2-0.9-1.2
Delta time to tail flick, test, before/after SA1.21.12.00.91.4-1.0-1.0-1.0-0.41.11.11.40.8
Tibia length0.51.32.20.91.1-1.2-1.3-1.20.81.51.51.20.4
Ambulatory time before self-admin0.20.21.1-0.2-0.20.30.30.3-1.10.20.20.10.4
Ambulatory time after self-admin0.00.00.1-0.10.10.10.10.10.3-0.2-0.2-0.2-0.1
Bone: tissue strength0.20.20.50.20.7-0.4-0.5-0.4-0.10.50.50.7-0.2
Total heroin consumption1.01.22.71.11.0-1.2-1.2-1.21.60.90.90.90.6
Bone: trabecular number0.00.00.20.2-0.2-0.2-0.1-0.10.40.00.00.0-0.4
Bone: trabecular spacing0.10.10.5-0.3-0.10.20.10.1-0.70.20.2-0.00.3
Bone: trabecular thickness0.10.20.80.30.3-0.4-0.4-0.40.90.30.30.30.4
Bone: trabecular tissue density0.10.20.50.70.4-0.5-0.4-0.4-0.60.20.20.3-0.0
Water consumed over 24 hours2.63.13.92.01.8-2.0-1.9-1.91.41.41.42.01.7
Number of responses in last shaping day0.30.40.7-0.8-0.70.60.60.6-0.9-0.5-0.5-0.3-0.1