Hub : Genes

Tnfaip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Tnfaip1 0.18 0.14 3.8e-12 0.09 0.09 0.09 0.09 1.2e-10 1.3e-10 6.4e-10 3.4e-10
2 NAcc gene expression Tnfaip1 0.06 0.06 4.0e-07 0.04 0.04 0.04 0.03 3.3e-06 2.2e-07 4.3e-06 6.0e-06
3 pVTA gene expression Tnfaip1 0.11 0.09 3.9e-10 0.11 0.12 0.11 0.11 5.1e-09 1.2e-09 2.7e-09 2.5e-09
4 LHb gene expression Tnfaip1 0.29 0.22 1.7e-05 0.18 0.2 0.17 0.23 3.6e-05 1.4e-05 7.1e-05 3.8e-06
5 Liver gene expression Tnfaip1 0.15 0.09 0.0e+00 0.15 0.15 0.15 0.15 4.9e-16 1.2e-16 1.7e-16 1.1e-16
6 PL gene expression Tnfaip1 0.05 0.05 5.1e-05 0.05 0.04 0.05 0.04 4.8e-06 2.2e-05 8.0e-06 1.3e-05
7 RMTg mRNA stability Tnfaip1 0.11 0.1 4.0e-03 0.05 0.06 0.07 0.06 1.7e-02 8.5e-03 6.2e-03 1.1e-02
8 Brain gene expression Tnfaip1 0.35 0.23 2.4e-04 0.04 0.04 0.05 0.03 3.2e-04 2.1e-04 3.4e-05 3.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.93.33.9-1.9-1.9-2.0-1.9-1.8-1.92.0-1.1
Area under the delay curve0.80.91.90.90.91.40.31.30.2-1.3-0.6
BMI with tail1.96.67.1-2.6-2.6-2.6-2.7-2.7-2.52.7-2.2
BMI without tail1.85.46.5-2.4-2.4-2.5-2.5-2.4-2.32.4-1.5
Body weight2.812.413.5-3.6-3.6-3.5-3.7-3.5-3.43.5-3.4
Weight adjusted by age0.20.30.8-0.2-0.1-0.3-0.9-0.3-0.90.10.7
Bone surface1.42.63.3-1.6-1.6-1.8-1.7-1.6-1.61.8-1.2
Bone volume1.42.53.0-1.6-1.6-1.6-1.7-1.5-1.71.6-1.2
Breakpoint value in progressive ratio session0.20.20.5-0.4-0.4-0.70.2-0.40.20.60.4
Number of licking bursts0.40.71.60.70.70.71.30.71.3-0.60.4
Context. condit. distance diff. score0.60.70.9-0.9-0.8-0.8-1.0-0.8-1.00.8-0.4
Locomotion velocity, session 12.02.22.6-1.6-1.6-1.6-1.3-1.5-1.21.6-1.5
Locomotion distance, session 10.20.30.8-0.6-0.6-0.6-0.0-0.40.20.6-0.9
Locomotion velocity, session 20.00.00.0-0.1-0.1-0.20.1-0.10.20.2-0.1
Locomotion distance, session 20.91.31.9-1.2-1.3-1.3-0.8-1.3-0.81.4-0.8
Locomotion velocity, session 33.43.84.72.12.12.02.22.02.1-1.71.5
Locomotion distance, session 30.30.30.50.60.60.70.70.60.7-0.50.1
Stereotopy head waving bouts, day 30.00.00.10.10.0-0.1-0.00.1-0.10.20.3
Stereotopy head waving duration, day 30.91.12.01.11.10.81.01.00.9-0.81.4
Locomotion velocity, session 70.20.20.4-0.3-0.3-0.5-0.6-0.3-0.60.30.2
Locomotion distance, session 70.30.40.5-0.6-0.6-0.7-0.7-0.7-0.60.6-0.1
Stereotopy head waving bouts, day 70.50.50.8-0.7-0.7-0.8-0.8-0.7-0.90.7-0.1
Stereotopy head waving duration, day 70.10.20.3-0.3-0.3-0.5-0.5-0.4-0.50.40.3
Locomotion velocity, session 80.10.10.5-0.2-0.3-0.2-0.1-0.2-0.10.4-0.7
Locomotion distance, session 80.71.01.5-1.1-1.1-1.1-0.8-1.0-0.81.2-0.7
Degree of sensitization distance2.72.83.7-1.7-1.7-1.8-1.9-1.7-1.91.6-0.8
Degree of sensitization stereotypy0.40.50.6-0.7-0.7-0.8-0.7-0.8-0.80.7-0.1
Conditioned locomotion2.02.33.41.61.61.41.81.51.9-1.01.2
Cocaine response after cond. corrected1.41.62.1-1.4-1.4-1.4-1.1-1.4-1.21.4-0.8
Cocaine response after cond. not corrected1.92.22.7-1.6-1.6-1.6-1.3-1.6-1.41.6-0.9
Cocaine response before conditioning0.10.20.3-0.5-0.4-0.5-0.4-0.4-0.40.4-0.3
Saline control response0.00.10.30.10.20.00.20.10.2-0.10.6
Bone: connectivity density3.25.17.0-2.3-2.3-2.5-2.2-2.3-2.22.6-1.3
Bone: cortical apparent density0.50.70.90.90.90.80.80.80.9-0.90.9
Bone: cortical area0.91.42.21.41.31.51.11.41.1-1.2-0.0
Bone: cortical porosity0.20.30.5-0.5-0.4-0.5-0.7-0.5-0.60.30.2
Bone: cortical porosity0.10.10.3-0.3-0.3-0.3-0.5-0.3-0.50.20.2
Bone: cortical thickness2.33.84.92.12.22.21.72.21.8-2.11.1
Bone: cortical thickness0.10.10.20.30.30.20.40.30.4-0.10.4
Bone: cortical tissue density0.30.50.50.70.70.60.60.60.7-0.70.7
Condit. Reinf. active minus inactive responses0.80.91.01.01.00.90.91.00.9-0.90.9
Condit. Reinf. active-inactive response ratio0.10.20.20.40.40.40.30.50.3-0.40.4
Condit. Reinf. active responses0.00.00.10.20.20.10.30.20.3-0.10.1
Condit. Reinf. inactive responses0.20.30.5-0.5-0.6-0.6-0.3-0.6-0.20.7-0.4
Incentive salience index mean0.20.30.40.60.60.60.50.60.4-0.50.5
Condit. Reinf. lever presses0.20.20.6-0.3-0.4-0.4-0.6-0.3-0.70.5-0.3
Condit. Reinf. active minus inactive responses1.01.32.51.01.00.71.40.91.4-0.81.6
Condit. Reinf. active-inactive response ratio1.01.11.91.01.00.91.40.91.4-0.81.2
Condit. Reinf. active responses0.60.92.00.90.90.61.10.80.9-0.71.4
Condit. Reinf. inactive responses0.00.00.20.00.1-0.1-0.20.1-0.3-0.10.4
Condit. Reinf. lever presses2.73.74.81.91.91.92.21.92.2-1.81.6
Condit. Reinf. lever reinforcers received0.91.22.01.11.10.81.31.01.2-0.91.4
Conditioned reinforcement - actives0.20.40.5-0.6-0.7-0.7-0.6-0.6-0.40.7-0.4
Conditioned reinforcement - inactives0.30.41.6-0.4-0.6-0.4-0.5-0.4-0.30.5-1.3
Conditioned locomotion0.60.81.1-0.8-1.0-0.7-1.0-0.8-1.10.8-1.0
Patch foraging indifference point 0 sec0.40.81.01.01.00.91.00.91.0-0.60.6
Patch foraging indifference point AUC2.23.24.81.81.81.82.21.72.1-1.31.5
Delay disc. indifference point, 0s delay0.50.60.90.50.71.00.70.90.9-0.9-0.0
Delay disc. indifference point, 16s delay0.60.71.70.50.51.1-0.41.0-0.2-1.1-1.3
Delay disc. indifference point, 2s delay2.02.22.91.61.61.71.41.71.2-1.70.9
Delay disc. indifference point, 24s delay0.91.02.0-0.9-0.9-0.9-1.3-0.8-1.40.9-0.7
Delay disc. indifference point, 4s delay0.20.20.30.10.20.40.20.6-0.3-0.5-0.6
Delay disc. indifference point, 8s delay0.30.40.90.70.61.0-0.00.80.0-0.7-0.2
Indifference point function ln k0.50.91.7-0.9-0.9-0.9-1.3-0.7-1.20.5-0.9
Indifference point function log k0.50.91.7-0.9-0.9-0.9-1.3-0.7-1.20.5-0.9
Patch foraging total patch changes 0 sec0.40.70.90.90.90.80.90.90.9-0.50.7
Patch foraging total patch changes 12 sec0.20.30.80.40.40.50.90.40.9-0.0-0.1
Patch foraging total patch changes 18 sec1.82.84.21.61.71.62.01.62.0-1.41.2
Patch foraging total patch changes 24 sec2.13.75.72.01.91.82.41.82.2-1.51.6
Patch foraging total patch changes 6 sec2.94.46.12.22.22.32.52.02.4-1.81.4
Patch foraging time to switch 0 sec1.42.83.0-1.7-1.7-1.6-1.7-1.6-1.71.7-1.5
Patch foraging water rate 0 sec1.63.34.31.81.91.82.01.82.1-1.71.3
Patch foraging water rate 12 sec0.10.20.3-0.4-0.3-0.5-0.6-0.4-0.50.3-0.2
Patch foraging water rate 18 sec0.50.81.5-0.9-0.8-0.8-1.2-0.8-1.20.4-0.5
Patch foraging water rate 24 sec0.10.20.30.30.30.50.40.40.5-0.4-0.5
Patch foraging water rate 6 sec1.11.52.51.21.31.31.01.31.2-1.60.9
Seeking ratio, delayed vs. immediate footshock1.41.82.31.41.31.51.41.41.2-1.40.8
Distance traveled before self-admin2.63.44.82.12.22.21.32.01.3-1.81.5
Distance traveled after self-admin0.00.10.10.20.30.3-0.20.2-0.2-0.10.1
Extensor digitorum longus weight0.83.34.6-1.8-1.8-1.8-2.0-1.8-2.21.7-1.4
Bone: elastic displacement2.63.03.61.91.91.91.71.91.7-1.81.1
Bone: elastic work7.49.611.93.43.33.43.13.43.1-3.11.4
Bone: endosteal estimation0.00.10.8-0.1-0.2-0.00.1-0.00.10.2-0.9
Bone: endosteal perimeter0.10.21.4-0.3-0.4-0.2-0.1-0.3-0.10.4-1.2
Epididymis fat weight8.228.033.2-5.6-5.4-5.4-5.8-5.5-5.55.0-4.1
Delta time in closed arm before/after self-admin2.62.43.51.81.81.70.81.90.8-1.81.3
Delta time in open arm before/after self-admin5.45.37.8-2.8-2.7-2.6-1.2-2.8-1.22.6-1.9
Diff in mean of infusions in LGA sessions0.40.50.7-0.9-0.9-0.8-0.2-0.8-0.20.9-0.7
Delay discount exponential model param0.60.61.3-0.7-0.7-1.1-0.1-1.10.01.10.5
Extinction: sum of active levers before priming0.60.61.1-1.0-0.9-1.0-0.5-0.8-0.51.0-0.3
Active lever presses in extinction session 60.20.20.4-0.1-0.0-0.5-0.6-0.2-0.60.50.6
Bone: final force0.20.30.50.60.50.70.40.70.5-0.4-0.4
Bone: final moment0.20.30.50.60.60.70.40.70.5-0.5-0.3
Food consumed during 24 hour testing period0.30.51.00.70.80.50.10.90.1-1.00.9
Glucose1.32.12.61.51.51.51.31.41.2-1.61.4
Heart weight1.21.82.5-1.3-1.4-1.6-1.4-1.2-1.21.5-1.1
Delay discount hyperbolic model param0.90.91.8-1.0-1.0-1.3-0.5-1.3-0.31.30.2
Intermittent access intake day 1-15 change0.10.10.8-0.1-0.1-0.2-0.1-0.10.00.10.9
Intermittent access intake escalation0.10.10.4-0.3-0.3-0.4-0.2-0.3-0.00.20.6
Intermittent access intake escalation 20.20.31.00.40.40.40.30.40.4-0.41.0
Intermitt. access day 1 inactive lever presses0.00.10.30.40.30.40.30.40.6-0.4-0.0
Intermitt. access day 15 inactive lever presses0.61.33.10.90.80.81.70.91.8-0.80.7
Intermitt. access escalation Index1.31.82.7-1.5-1.3-1.1-1.5-1.4-1.71.1-1.2
Intermittent access day 1 total infusions0.30.51.6-0.6-0.7-0.5-0.3-0.6-0.30.7-1.2
Intermittent access day 15 total infusions0.71.11.7-1.2-1.3-1.2-0.6-1.2-0.51.3-0.8
Intermittent access terminal intake (last 3 days)1.11.41.9-1.3-1.4-1.2-0.9-1.2-0.91.4-1.0
Intermittent access total infusions0.40.40.8-0.7-0.9-0.7-0.3-0.7-0.30.9-0.4
Intermittent access day 1 locomotion0.10.10.5-0.3-0.4-0.2-0.2-0.2-0.20.4-0.7
Intermittent access day 15 total locomotion0.30.60.7-0.7-0.8-0.8-0.8-0.7-0.80.8-0.5
Intermittent access total locomotion0.60.71.0-0.9-1.0-0.9-0.7-0.8-0.71.0-0.6
Intermittent access standard deviation0.00.10.2-0.2-0.2-0.00.4-0.20.40.20.0
Left kidney weight0.10.41.3-0.6-0.6-0.5-0.6-0.5-0.50.6-1.2
Right kidney weight0.21.01.7-0.9-0.9-0.9-1.0-0.9-0.91.0-1.3
Cocaine induced anxiety0.20.30.90.40.40.40.80.40.9-0.4-0.1
Post-drug Anxiety0.10.10.2-0.3-0.2-0.4-0.0-0.30.00.30.4
Baseline Anxiety0.20.31.0-0.3-0.3-0.5-0.3-0.4-0.80.31.0
Tail length0.41.51.9-1.4-1.2-1.3-1.4-1.3-1.31.0-0.8
Length with tail0.72.93.6-1.8-1.7-1.6-1.9-1.6-1.71.4-1.7
Length without tail0.62.03.2-1.4-1.3-1.1-1.6-1.3-1.31.3-1.8
Times rat made contact with spout0.20.20.60.40.40.2-0.30.4-0.3-0.60.8
Lifetime Intake0.70.81.3-1.0-1.1-0.9-0.5-1.0-0.51.1-1.0
Liver weight, left4.87.99.3-2.9-2.9-2.9-2.9-2.8-3.02.9-1.9
Liver weight, right3.76.57.2-2.6-2.6-2.7-2.6-2.6-2.62.6-2.1
Locomotor activity0.10.10.20.10.10.20.40.20.4-0.30.3
Locomotor testing distance0.10.10.20.30.30.30.50.20.4-0.40.5
Locomotor testing rearing0.20.41.20.40.40.30.80.40.7-0.51.1
Locomotion in novel chamber1.51.93.21.71.61.80.41.50.4-1.51.3
Locomotion in novel chamber post-restriction0.10.20.60.0-0.0-0.0-0.7-0.2-0.60.00.8
Fecal boli incidents, locomotor time 11.01.52.1-1.2-1.2-1.5-1.1-1.4-1.21.4-0.1
Change in fecal boli incidents, locomotor task0.20.21.0-0.0-0.00.30.10.3-0.2-0.2-1.0
Time >=10cm from walls, locomotor time 10.00.00.0-0.1-0.1-0.2-0.1-0.1-0.10.10.2
Bouts of movement, locomotor time 10.30.30.50.60.60.70.50.70.5-0.70.1
Total resting periods, locomotor time 10.10.10.10.40.40.40.40.40.2-0.40.1
Rest time, locomotor task time 10.10.20.5-0.2-0.2-0.40.4-0.50.20.40.7
Distance moved, locomotor task time 10.10.20.40.40.30.60.20.60.3-0.6-0.4
Vertical activity count, locomotor time 10.10.10.9-0.0-0.10.30.10.2-0.1-0.2-0.9
Time >=10cm from walls, locomotor time 20.71.11.5-1.2-1.2-1.1-0.2-1.1-0.91.1-1.0
Bouts of movement, locomotor time 20.30.50.80.70.70.70.90.90.5-0.80.2
Total resting periods, locomotor time 20.10.20.30.40.50.30.50.60.3-0.50.3
Rest time, locomotor task time 20.60.84.10.60.70.10.70.20.8-0.12.0
Distance moved, locomotor task time 20.20.21.00.00.00.5-0.20.30.0-0.4-1.0
Vertical activity count, locomotor time 20.40.53.7-0.2-0.20.60.00.2-0.1-0.3-1.9
Light reinforcement 10.00.00.0-0.0-0.00.1-0.0-0.0-0.1-0.0-0.1
Light reinforcement 20.20.40.50.70.70.70.50.70.5-0.70.2
Bone: marrow area0.00.10.8-0.1-0.1-0.00.1-0.00.10.2-0.9
Bone: maximum diameter0.20.40.60.60.60.80.50.70.6-0.5-0.6
Bone: maximum force0.30.50.90.80.80.90.60.90.6-0.8-0.2
Bone: maximum moment0.30.61.00.80.81.00.60.90.6-0.9-0.2
Mean time between licks in bursts0.51.21.6-1.0-1.0-1.0-1.3-1.0-1.31.0-1.0
Mean num. licks in bursts0.50.82.4-0.6-0.6-0.7-1.6-0.5-1.60.3-0.0
Cd content in liver0.80.92.20.80.70.91.50.81.4-0.6-0.2
Co content in liver0.70.81.70.70.60.71.10.51.3-0.81.1
Cu content in liver1.82.12.51.61.61.41.61.51.5-1.31.0
Fe content in liver1.82.23.3-1.6-1.7-1.7-0.7-1.5-0.81.8-1.6
K content in liver0.20.10.3-0.5-0.4-0.3-0.4-0.4-0.40.4-0.3
Mg content in liver0.91.02.00.90.90.81.41.01.4-0.70.4
Mn content in liver0.30.40.60.60.60.50.60.60.6-0.60.8
Na content in liver0.30.30.9-0.7-0.6-0.3-0.3-0.5-0.30.4-1.0
Rb content in liver0.10.10.2-0.5-0.4-0.30.3-0.30.30.5-0.1
Se content in liver1.31.54.21.00.90.82.11.02.0-0.80.4
Sr content in liver0.40.30.6-0.6-0.5-0.6-0.8-0.6-0.60.10.5
Zn content in liver0.40.41.3-0.6-0.7-0.70.1-0.60.10.7-1.1
Bone: minimum diameter0.10.10.30.30.20.30.20.30.2-0.1-0.5
Time in familiar zone, hab. session 10.20.20.40.40.50.60.20.40.2-0.60.2
Time in novel zone, hab. session 10.10.10.2-0.3-0.3-0.4-0.1-0.3-0.10.30.1
Total zone transitions, hab. session 10.00.00.20.00.00.20.10.10.2-0.1-0.4
Total locomotion distance, hab. session 10.10.10.30.30.40.40.30.40.3-0.50.3
Locomotion velocity, hab. session 10.30.40.50.60.60.70.60.70.7-0.60.2
Time in familiar zone, hab. session 20.40.40.80.50.60.40.70.50.7-0.50.9
Time in novel zone, hab. session 20.10.10.30.20.10.30.00.20.0-0.2-0.5
Total zone transitions, hab. session 20.20.30.4-0.6-0.6-0.6-0.4-0.6-0.40.5-0.5
Total locomotion distance, hab. session 20.20.20.50.40.40.30.70.40.7-0.40.5
Locomotion velocity, hab. session 20.20.30.50.40.40.30.70.50.7-0.40.5
Novel to familiar place preference ratio0.90.91.1-1.0-1.0-1.0-1.1-1.0-1.10.9-0.7
Novelty place preference1.11.21.4-1.1-1.1-1.1-1.2-1.1-1.21.1-0.8
Time in novel zone, NPP test1.21.31.5-1.2-1.2-1.2-1.2-1.1-1.21.1-0.8
Total zone transitions, NPP test0.00.10.2-0.1-0.2-0.10.3-0.10.30.3-0.5
Total locomotion distance, NPP test1.11.52.61.21.21.11.61.21.6-1.00.8
Locomotion velocity, NPP test1.31.82.91.31.31.21.71.31.7-1.10.8
Intraocular pressure1.11.61.91.31.41.31.11.31.1-1.41.2
Delta distance traveled before/after self-admin2.62.73.5-1.9-1.8-1.8-1.5-1.7-1.51.6-1.3
Delta ambulatory time before/after self-admin1.62.03.1-1.8-1.7-1.7-0.7-1.5-0.71.4-1.3
Parametrial fat weight5.512.914.7-3.8-3.7-3.8-3.8-3.7-3.63.7-2.4
Pavlov. Cond. lever latency0.00.00.1-0.1-0.0-0.10.0-0.10.1-0.20.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.2-0.2-0.2-0.1-0.2-0.10.4-0.5
Pavlov. Cond. change in total contacts0.30.40.40.60.60.60.60.60.5-0.60.6
Pavlov. Cond. index score0.00.00.00.10.00.10.10.10.00.1-0.2
Pavlov. Cond. latency score0.00.00.1-0.0-0.1-0.0-0.0-0.1-0.10.3-0.3
Pavlov. Cond. lever contacts0.00.00.1-0.1-0.10.0-0.1-0.1-0.30.2-0.2
Pavlov. Cond. magazine entry number0.10.10.2-0.4-0.3-0.4-0.4-0.3-0.40.20.0
Pavlov. Cond. intertrial magazine entries0.30.40.80.60.60.50.80.60.9-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.20.10.20.30.20.20.1-0.2
Pavlov. Cond. response bias0.00.00.1-0.0-0.10.10.1-0.0-0.00.2-0.4
Pavlov. Cond. lever latency2.63.64.6-1.9-1.9-1.9-2.1-1.9-2.21.7-1.4
Pavlov. Cond. magazine entry latency0.20.20.30.50.50.50.50.50.5-0.40.3
Pavlov. Cond. change in total contacts1.42.23.21.51.51.51.71.51.8-1.31.1
Pavlov. Cond. index score2.43.24.21.81.81.82.01.82.0-1.61.4
Pavlov. Cond. latency score2.83.74.61.91.91.92.12.02.1-1.81.5
Pavlov. Cond. lever contacts1.72.33.21.51.51.41.81.51.8-1.31.3
Pavlov. Cond. magazine entry number0.00.10.2-0.1-0.1-0.1-0.4-0.2-0.40.0-0.2
Pavlov. Cond. intertrial magazine entries0.40.50.6-0.7-0.7-0.8-0.8-0.8-0.80.7-0.5
Pavlov. Cond. lever-magazine prob. diff.1.92.53.31.61.61.51.81.61.8-1.41.3
Pavlov. Cond. response bias1.31.72.41.31.31.31.51.31.6-1.11.0
Time in closed arm before self-admin1.62.12.8-1.6-1.6-1.4-1.1-1.7-1.11.6-1.3
Time in closed arm after self-admin0.30.40.80.60.50.9-0.60.6-0.6-0.6-0.4
Time in open arm before self-admin2.42.73.41.81.81.51.21.81.2-1.91.8
Time in open arm after self-admin0.60.71.1-1.0-1.0-1.1-0.1-1.1-0.10.9-0.4
Bone: periosteal estimation0.20.50.70.70.70.80.70.80.7-0.5-0.6
Bone: periosteal perimeter0.20.30.90.40.30.60.20.50.3-0.4-0.9
Bone: post-yield work0.50.71.2-0.7-0.7-0.6-1.1-0.7-1.10.6-0.8
Progressive ratio test 1 active lever presses0.40.51.10.50.50.70.90.61.1-0.60.5
Progressive ratio test 1 breakpoint0.50.61.40.60.50.81.10.61.2-0.70.5
Progressive ratio test 1 inactive lever presses1.01.42.11.21.11.41.41.21.4-1.30.0
Progressive ratio test 2 active lever presses0.30.40.70.60.60.60.70.70.9-0.50.4
Progressive ratio test 2 breakpoint0.40.40.80.60.60.60.80.60.9-0.40.5
Progressive ratio test 2 inactive lever presses0.10.10.20.40.20.30.20.40.3-0.3-0.1
Incentive Sensitization - Responses0.00.00.00.20.0-0.1-0.00.10.10.2-0.2
Incentive Sensitization - Breakpoint0.00.00.10.10.0-0.2-0.00.10.00.2-0.2
Sum of active levers in priming session hrs 5-61.00.91.5-1.2-1.1-1.2-0.5-1.0-0.51.2-0.6
Progressive ratio0.10.10.90.00.2-0.20.3-0.00.30.01.0
Food seeking constrained by brief footshock0.10.10.2-0.3-0.3-0.30.1-0.40.10.4-0.5
Seeking ratio, punishment vs. effort0.10.10.80.0-0.10.3-0.3-0.0-0.2-0.1-0.9
Retroperitoneal fat weight0.72.93.8-1.8-1.7-1.5-2.0-1.8-1.81.5-1.5
Reaction time number correct0.61.21.6-1.3-1.2-1.1-1.1-1.2-0.91.1-0.9
Reaction time mean minus median0.10.20.4-0.4-0.5-0.5-0.2-0.5-0.20.6-0.0
Reaction time mean minus median AUC0.92.22.8-1.5-1.6-1.5-1.3-1.7-1.31.7-1.0
Reaction time num false alarms5.37.58.72.92.92.92.52.82.6-2.92.2
Reaction time num false alarms AUC4.97.68.92.93.02.92.52.92.7-3.02.2
Reaction time trials correct on left0.61.21.6-1.3-1.2-1.1-1.1-1.2-0.91.1-0.9
Reaction time trials on left0.71.31.6-1.3-1.2-1.2-1.2-1.2-1.01.1-0.9
Reaction time mean0.40.71.0-0.9-0.9-1.0-0.6-0.9-0.51.0-0.6
Reaction time mean AUC0.40.60.8-0.8-0.9-0.9-0.5-0.9-0.50.9-0.6
Median of all reaction times0.30.40.7-0.7-0.8-0.8-0.3-0.7-0.20.9-0.6
Reaction time omissions1.42.03.2-1.4-1.4-1.4-1.7-1.4-1.81.3-0.9
Reaction time false alarm rate5.77.89.03.03.02.92.62.92.6-3.02.2
Reaction time premature initiation rate0.30.50.7-0.6-0.7-0.5-0.8-0.6-0.80.6-0.9
Reaction time premature initiations0.50.81.1-0.9-0.9-0.8-1.1-0.8-1.00.8-0.9
Std. dev. reaction times0.51.01.3-1.1-1.1-1.1-0.9-1.1-0.91.1-0.6
Reaction time trials completed0.71.31.6-1.3-1.2-1.2-1.2-1.2-1.01.1-0.9
Reaction time trials AUC0.51.01.3-1.1-1.0-1.0-1.0-1.0-0.81.0-0.7
Run reversals in cocaine runway, females0.30.30.9-0.3-0.2-0.3-1.0-0.2-0.70.2-0.7
Run reversals in cocaine runway, males0.30.30.9-0.4-0.4-0.2-0.9-0.5-0.90.20.0
Latency to leave start box in cocaine runway1.11.33.71.21.30.70.91.00.6-0.91.9
Latency to leave start box in cocaine runway, F0.40.51.90.60.70.20.50.50.3-0.51.4
Latency to leave start box in cocaine runway, M0.50.41.30.90.80.40.20.6-0.1-0.31.1
Std. dev. time between licks in bursts0.20.20.6-0.2-0.3-0.2-0.8-0.2-0.80.2-0.6
Total sessions with >9 infusions0.91.13.2-1.0-1.1-0.7-0.9-0.9-0.81.0-1.8
Short access day 1 total inactive lever presses4.05.36.1-2.3-2.5-2.2-2.3-2.3-2.22.4-2.3
Short access day 10 total inactive lever presses0.00.00.2-0.0-0.10.10.1-0.10.40.1-0.4
Short access day 1 total infusions1.01.43.7-1.2-1.4-0.9-0.3-1.1-0.41.3-1.9
Short access day 10 total infusions0.60.81.7-0.9-1.0-0.7-0.5-0.8-0.60.9-1.3
Short access total infusions0.40.51.5-0.8-0.9-0.5-0.2-0.7-0.20.8-1.2
Short access day 1 locomotion0.10.10.7-0.2-0.30.10.4-0.10.30.1-0.8
Short access day 10 total locomotion0.50.92.30.70.70.81.50.81.5-0.80.6
Short access total locomotion0.30.40.70.50.40.70.80.60.8-0.6-0.3
One hour access (0.3 mA shock)0.10.10.30.20.10.20.50.20.60.00.4
Compulsive drug intake0.91.11.5-1.1-1.1-1.1-0.9-1.1-0.91.2-0.9
One hour access (shock baseline)0.10.20.50.40.30.40.50.40.6-0.30.7
Social response proportion2.73.13.5-1.9-1.9-1.7-1.8-1.7-1.71.7-1.7
Social responses1.72.32.8-1.7-1.7-1.6-1.3-1.6-1.31.6-1.1
Social time1.82.53.1-1.6-1.7-1.5-1.4-1.7-1.81.5-1.2
Soleus weight2.26.67.5-2.5-2.6-2.6-2.7-2.6-2.72.6-2.0
Bone: stiffness1.93.13.6-1.9-1.9-1.8-1.7-1.8-1.71.8-1.3
Tibialis anterior weight2.79.110.3-3.0-3.1-3.1-3.1-3.1-3.23.1-2.3
Time to tail flick, vehicle, before self-admin0.50.51.1-0.5-0.5-0.3-0.9-0.4-0.90.5-1.0
Time to tail flick, vehicle, after self-admin0.30.40.90.50.50.70.90.60.9-0.60.1
Time to tail flick, test, before self-admin0.10.10.20.10.0-0.1-0.4-0.0-0.4-0.00.4
Time to tail flick, test, after self-admin1.61.65.51.21.20.70.61.30.6-1.22.4
Delta time to tail flick, vehicle, before/after SA1.21.22.10.90.90.61.50.91.4-0.91.3
Delta time to tail flick, test, before/after SA0.80.81.30.80.80.71.10.91.1-0.80.9
Tibia length0.00.00.20.10.10.2-0.10.2-0.2-0.1-0.4
Ambulatory time before self-admin0.60.92.21.21.21.50.21.10.2-0.90.1
Ambulatory time after self-admin0.10.10.2-0.2-0.1-0.0-0.5-0.1-0.50.2-0.4
Bone: tissue strength1.11.11.81.21.21.30.81.20.8-1.20.3
Total heroin consumption1.82.13.9-1.5-1.4-2.0-1.3-1.5-1.31.7-0.2
Bone: trabecular number2.54.15.2-2.1-2.1-2.3-2.0-2.1-2.02.3-1.1
Bone: trabecular spacing0.20.20.40.50.50.60.30.50.2-0.70.2
Bone: trabecular thickness0.00.00.30.0-0.00.00.00.1-0.00.2-0.5
Bone: trabecular tissue density1.21.82.61.41.41.41.51.31.6-1.20.7
Water consumed over 24 hours0.00.10.10.20.20.20.30.40.3-0.20.0
Number of responses in last shaping day0.91.01.51.00.91.21.01.01.2-0.9-0.3