Hub : Genes

Tmprss9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr7_8817289_8819686 0.04 0.07 9.2e-04 0.02 0.01 0.02 0.01 4.1e-03 9.8e-03 2.3e-03 7.6e-03
2 NAcc mRNA stability Tmprss9 0.05 0.04 1.1e-08 0.07 0.07 0.07 0.07 9.8e-09 8.0e-09 1.5e-08 1.2e-08
3 LHb gene expression Tmprss9 0.52 0.18 4.4e-13 0.4 0.37 0.38 0.4 1.2e-10 8.0e-10 4.3e-10 1.7e-10
4 OFC gene expression Tmprss9 0.36 0.19 3.6e-07 0.22 0.21 0.21 0.21 6.1e-06 1.2e-05 8.6e-06 9.3e-06
5 pVTA gene expression Tmprss9 0.33 0.15 5.6e-17 0.36 0.35 0.35 0.35 1.5e-16 6.8e-16 5.6e-16 4.1e-16
6 NAcc gene expression Tmprss9 0.3 0.14 0.0e+00 0.4 0.4 0.4 0.4 9.2e-50 9.3e-49 1.3e-49 5.1e-49
7 BLA gene expression Tmprss9 0.18 0.11 7.1e-10 0.17 0.17 0.17 0.18 1.8e-09 1.3e-09 1.2e-09 9.0e-10
8 PL gene expression Tmprss9 0.15 0.09 0.0e+00 0.21 0.22 0.22 0.22 5.4e-23 2.3e-23 3.1e-23 1.2e-23
9 IL gene expression Tmprss9 0.13 0.1 7.2e-03 0.02 0.02 0.02 0.01 1.1e-01 1.1e-01 1.1e-01 2.0e-01
10 LHb mRNA stability Tmprss9 0.26 0.15 8.6e-06 0.24 0.2 0.21 0.21 2.1e-06 1.5e-05 1.2e-05 8.3e-06
11 Liver gene expression Tmprss9 0.17 0.1 0.0e+00 0.15 0.16 0.15 0.16 3.1e-16 7.8e-17 2.8e-16 6.0e-17
12 RMTg gene expression Tmprss9 0.26 0.18 6.6e-05 0.13 0.11 0.14 0.1 2.6e-04 7.5e-04 1.5e-04 1.5e-03
13 Brain mRNA stability Tmprss9 0.16 0.1 1.7e-14 0.14 0.14 0.14 0.14 1.1e-12 1.6e-12 6.8e-13 8.2e-13
14 Brain gene expression Tmprss9 0.29 0.13 0.0e+00 0.26 0.27 0.28 0.27 2.7e-24 2.1e-25 1.0e-25 1.7e-25

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.27.6-1.30.4-0.6-0.6-0.6-0.60.60.6-0.8-0.80.9-2.8-1.1-1.2
Area under the delay curve2.42.53.30.91.6-1.6-1.6-1.6-1.81.81.8-1.6-1.61.7-0.4-1.6-1.7
BMI with tail5.517.721.63.24.6-4.5-4.5-4.5-4.64.64.6-4.5-4.54.4-0.2-4.1-4.1
BMI without tail1.94.010.03.22.1-2.0-2.0-2.0-2.02.02.0-1.9-1.91.81.7-1.4-1.5
Body weight1.04.14.81.92.2-2.2-2.2-2.2-2.22.22.1-2.1-2.12.10.4-1.9-2.0
Weight adjusted by age0.50.53.61.70.4-0.4-0.4-0.4-0.20.20.3-0.3-0.30.21.90.00.0
Bone surface0.81.513.0-1.9-0.0-0.3-0.3-0.3-0.30.30.3-0.5-0.50.7-3.6-1.0-1.1
Bone volume0.71.311.3-1.7-0.0-0.4-0.4-0.4-0.30.30.3-0.5-0.50.7-3.4-1.0-1.1
Breakpoint value in progressive ratio session5.35.97.1-0.1-2.62.72.72.72.7-2.7-2.52.62.6-2.60.62.62.6
Number of licking bursts0.20.21.11.1-0.10.20.20.20.2-0.2-0.10.10.1-0.30.90.40.4
Context. condit. distance diff. score0.30.41.51.20.6-0.6-0.6-0.6-0.60.60.6-0.6-0.60.50.5-0.4-0.4
Locomotion velocity, session 10.50.53.3-1.8-0.60.60.60.60.4-0.4-0.60.50.5-0.4-0.90.20.2
Locomotion distance, session 11.11.411.1-3.30.0-0.1-0.1-0.1-0.20.20.1-0.1-0.10.3-2.6-0.8-0.6
Locomotion velocity, session 23.13.616.5-4.1-1.71.61.61.61.5-1.5-1.81.61.6-1.5-2.21.01.1
Locomotion distance, session 22.02.821.3-4.6-1.10.90.90.90.9-0.9-1.11.01.0-0.8-2.80.20.4
Locomotion velocity, session 35.56.47.6-0.8-2.82.82.82.82.7-2.7-2.72.82.8-2.70.72.72.6
Locomotion distance, session 30.10.10.60.5-0.00.20.20.20.0-0.00.0-0.0-0.0-0.10.80.10.0
Stereotopy head waving bouts, day 33.84.55.4-1.7-2.32.22.22.22.2-2.2-2.32.32.3-2.1-1.11.92.0
Stereotopy head waving duration, day 34.75.67.0-1.5-2.62.52.52.52.5-2.5-2.62.62.6-2.5-0.52.32.3
Locomotion velocity, session 70.80.92.91.0-0.90.80.80.80.8-0.8-0.90.80.8-0.81.71.00.7
Locomotion distance, session 70.30.43.81.20.1-0.0-0.0-0.0-0.10.10.1-0.1-0.1-0.02.00.30.1
Stereotopy head waving bouts, day 70.20.22.1-0.40.2-0.2-0.2-0.2-0.30.30.2-0.2-0.20.4-1.5-0.5-0.5
Stereotopy head waving duration, day 70.20.22.4-0.7-0.20.10.10.10.1-0.1-0.10.10.10.0-1.6-0.2-0.2
Locomotion velocity, session 80.60.75.1-2.3-0.40.30.30.30.3-0.3-0.40.40.4-0.1-2.0-0.1-0.1
Locomotion distance, session 80.20.32.4-1.6-0.20.10.10.10.2-0.2-0.20.20.2-0.2-1.1-0.10.0
Degree of sensitization distance0.30.30.50.30.6-0.7-0.7-0.7-0.60.60.5-0.6-0.60.60.1-0.5-0.6
Degree of sensitization stereotypy2.22.43.10.51.6-1.6-1.6-1.6-1.61.61.7-1.7-1.71.7-1.0-1.7-1.8
Conditioned locomotion0.91.12.61.61.2-1.1-1.1-1.1-1.01.01.0-0.9-0.90.91.4-0.6-0.6
Cocaine response after cond. corrected3.84.310.23.22.2-2.0-2.0-2.0-2.12.12.0-1.9-1.91.82.1-1.5-1.6
Cocaine response after cond. not corrected4.04.410.73.32.2-2.1-2.1-2.1-2.12.12.1-1.9-1.91.92.3-1.5-1.6
Cocaine response before conditioning0.30.40.5-0.1-0.70.70.70.70.7-0.7-0.70.70.7-0.60.20.70.6
Saline control response0.00.00.0-0.10.2-0.2-0.2-0.2-0.10.10.1-0.1-0.10.1-0.0-0.1-0.0
Bone: connectivity density0.81.34.8-0.90.8-0.9-0.9-0.9-1.01.00.9-1.1-1.11.1-2.2-1.3-1.3
Bone: cortical apparent density0.70.91.20.21.0-1.1-1.1-1.1-1.01.01.0-1.1-1.11.0-0.4-0.9-0.9
Bone: cortical area0.81.31.80.51.0-1.2-1.2-1.2-1.11.11.1-1.2-1.21.2-0.7-1.2-1.4
Bone: cortical porosity0.40.41.4-1.2-0.70.60.60.60.6-0.6-0.50.60.6-0.5-0.60.40.4
Bone: cortical porosity0.30.32.5-1.60.0-0.2-0.2-0.2-0.10.10.2-0.2-0.20.3-1.2-0.4-0.4
Bone: cortical thickness1.22.02.50.11.4-1.6-1.6-1.6-1.51.51.5-1.5-1.51.5-0.6-1.5-1.5
Bone: cortical thickness0.40.52.71.7-0.20.20.20.20.3-0.3-0.30.30.3-0.31.60.60.4
Bone: cortical tissue density0.50.60.80.10.8-0.9-0.9-0.9-0.80.80.8-0.9-0.90.8-0.3-0.8-0.7
Condit. Reinf. active minus inactive responses3.53.94.8-1.2-2.22.12.12.12.1-2.1-2.22.12.1-2.1-0.02.02.0
Condit. Reinf. active-inactive response ratio2.32.53.1-0.0-1.61.71.71.71.6-1.6-1.71.61.6-1.71.01.81.7
Condit. Reinf. active responses2.83.45.8-2.4-2.01.91.91.91.9-1.9-2.01.81.8-1.8-1.41.41.5
Condit. Reinf. inactive responses0.91.16.2-2.5-0.80.60.60.60.6-0.6-0.70.60.6-0.5-2.10.10.3
Incentive salience index mean1.61.93.2-1.8-1.51.41.41.41.4-1.4-1.41.41.4-1.3-1.21.11.1
Condit. Reinf. lever presses0.91.29.0-2.20.2-0.3-0.3-0.3-0.40.40.4-0.4-0.40.5-3.0-0.9-0.8
Condit. Reinf. active minus inactive responses2.73.34.00.3-1.92.02.02.01.9-1.9-1.91.91.9-2.01.32.02.0
Condit. Reinf. active-inactive response ratio0.50.51.10.4-0.50.60.60.60.6-0.6-0.60.60.6-0.81.00.80.9
Condit. Reinf. active responses2.23.03.60.5-1.91.91.91.91.8-1.8-1.81.81.8-1.81.21.91.8
Condit. Reinf. inactive responses0.91.21.40.6-1.21.11.11.11.1-1.1-1.11.21.2-1.01.01.21.0
Condit. Reinf. lever presses2.73.64.40.5-1.92.02.02.02.0-2.0-2.02.12.1-2.01.52.12.0
Condit. Reinf. lever reinforcers received1.92.73.30.9-1.71.71.71.71.7-1.7-1.61.71.7-1.71.61.81.7
Conditioned reinforcement - actives2.02.03.0-0.3-1.71.71.71.71.7-1.7-1.31.41.4-1.50.51.21.3
Conditioned reinforcement - inactives0.40.40.70.80.7-0.6-0.6-0.6-0.50.60.7-0.6-0.60.50.9-0.6-0.5
Conditioned locomotion6.57.910.5-0.9-3.23.23.23.23.1-3.1-2.82.92.9-3.00.52.62.7
Patch foraging indifference point 0 sec0.20.30.30.30.5-0.6-0.6-0.6-0.50.50.5-0.5-0.50.6-0.6-0.5-0.6
Patch foraging indifference point AUC1.01.11.4-0.6-1.11.21.21.21.1-1.1-1.01.01.0-1.10.41.11.1
Delay disc. indifference point, 0s delay8.89.612.8-1.23.1-3.1-3.1-3.1-3.13.13.3-3.2-3.23.3-2.9-3.6-3.5
Delay disc. indifference point, 16s delay0.20.20.50.70.4-0.4-0.4-0.4-0.50.50.4-0.4-0.40.4-0.3-0.4-0.5
Delay disc. indifference point, 2s delay5.96.68.30.72.7-2.7-2.7-2.7-2.72.72.9-2.8-2.82.8-1.1-2.7-2.8
Delay disc. indifference point, 24s delay0.80.84.42.10.8-0.7-0.7-0.7-0.90.90.6-0.7-0.70.70.6-0.5-0.7
Delay disc. indifference point, 4s delay1.51.62.10.91.2-1.3-1.3-1.3-1.41.41.4-1.2-1.21.3-1.1-1.3-1.5
Delay disc. indifference point, 8s delay0.90.91.20.61.1-1.0-1.0-1.0-1.11.11.1-1.0-1.01.00.7-0.8-0.9
Indifference point function ln k0.30.42.51.60.6-0.6-0.6-0.6-0.60.60.5-0.5-0.50.60.5-0.4-0.5
Indifference point function log k0.30.42.51.60.6-0.6-0.6-0.6-0.60.60.5-0.5-0.50.60.5-0.4-0.5
Patch foraging total patch changes 0 sec0.10.20.20.50.4-0.5-0.5-0.5-0.40.40.4-0.4-0.40.4-0.4-0.4-0.4
Patch foraging total patch changes 12 sec0.10.20.50.70.5-0.5-0.5-0.5-0.30.30.3-0.4-0.40.30.5-0.2-0.1
Patch foraging total patch changes 18 sec1.01.31.6-0.6-1.21.21.21.21.2-1.2-1.31.21.2-1.20.11.21.2
Patch foraging total patch changes 24 sec0.10.10.3-0.5-0.30.30.30.30.3-0.3-0.30.30.3-0.3-0.40.20.3
Patch foraging total patch changes 6 sec0.20.30.3-0.5-0.60.50.50.50.6-0.6-0.60.50.5-0.5-0.40.50.5
Patch foraging time to switch 0 sec2.43.66.1-2.41.7-1.9-1.9-1.9-1.71.71.6-1.6-1.61.8-2.5-2.1-1.9
Patch foraging water rate 0 sec0.91.49.73.1-0.40.60.60.60.5-0.5-0.30.30.3-0.62.50.90.8
Patch foraging water rate 12 sec0.91.49.23.00.9-0.7-0.7-0.7-0.80.80.8-0.7-0.70.62.1-0.2-0.3
Patch foraging water rate 18 sec1.82.411.03.3-0.70.90.90.90.9-0.9-0.80.90.9-1.23.11.51.5
Patch foraging water rate 24 sec1.01.49.83.00.20.10.10.10.0-0.00.1-0.0-0.0-0.33.10.70.6
Patch foraging water rate 6 sec1.42.06.92.4-1.01.11.11.11.0-1.0-1.01.01.0-1.22.61.51.4
Seeking ratio, delayed vs. immediate footshock3.64.15.4-0.9-2.32.32.32.32.2-2.2-2.22.12.1-2.1-0.51.91.9
Distance traveled before self-admin0.50.61.0-0.50.6-0.6-0.6-0.6-0.70.80.9-0.9-0.90.7-0.6-1.0-0.9
Distance traveled after self-admin0.50.60.8-0.5-0.90.90.90.90.8-0.8-0.70.80.8-0.8-0.30.50.5
Extensor digitorum longus weight3.614.017.82.94.2-3.9-3.9-3.9-4.14.14.2-4.1-4.13.81.2-3.5-3.4
Bone: elastic displacement0.20.20.4-0.4-0.50.60.60.60.5-0.5-0.50.50.5-0.5-0.10.40.4
Bone: elastic work0.20.30.50.50.5-0.6-0.6-0.6-0.60.60.5-0.6-0.60.60.2-0.6-0.7
Bone: endosteal estimation0.30.60.80.80.7-0.8-0.8-0.8-0.80.80.7-0.8-0.80.8-0.5-0.8-0.9
Bone: endosteal perimeter0.10.20.30.3-0.60.40.40.40.4-0.4-0.50.50.5-0.3-0.50.30.2
Epididymis fat weight0.20.60.9-0.6-0.70.70.70.70.8-0.8-0.80.80.8-0.8-0.00.91.0
Delta time in closed arm before/after self-admin0.90.85.42.30.5-0.3-0.3-0.3-0.20.20.5-0.4-0.40.12.30.10.1
Delta time in open arm before/after self-admin1.21.21.7-0.51.2-1.2-1.2-1.2-1.31.31.0-1.1-1.11.1-0.5-1.1-1.1
Diff in mean of infusions in LGA sessions1.61.72.1-0.8-1.41.41.41.41.3-1.3-1.51.51.5-1.4-0.31.41.4
Delay discount exponential model param2.12.22.9-1.1-1.51.51.51.51.7-1.7-1.71.51.5-1.60.21.51.6
Extinction: sum of active levers before priming1.61.62.20.5-1.31.41.41.41.5-1.4-1.11.21.2-1.40.81.41.4
Active lever presses in extinction session 62.52.43.2-0.8-1.81.81.81.81.8-1.7-1.51.61.6-1.6-0.11.31.4
Bone: final force1.52.43.00.81.5-1.7-1.7-1.7-1.61.61.6-1.6-1.61.7-0.6-1.6-1.7
Bone: final moment1.21.92.40.61.3-1.5-1.5-1.5-1.41.41.4-1.4-1.41.5-0.5-1.4-1.6
Food consumed during 24 hour testing period0.50.61.41.20.8-0.7-0.7-0.7-0.70.80.9-1.0-1.00.8-0.0-0.6-0.7
Glucose1.11.62.01.11.4-1.3-1.3-1.3-1.41.41.4-1.4-1.41.30.1-1.2-1.3
Heart weight0.50.71.20.3-0.80.80.80.80.8-0.8-0.80.80.8-0.91.11.01.0
Delay discount hyperbolic model param3.03.14.1-1.2-1.81.81.81.81.9-1.9-2.01.91.9-1.90.41.81.9
Intermittent access intake day 1-15 change6.66.58.0-0.6-2.82.82.82.82.8-2.8-2.72.72.7-2.70.92.62.6
Intermittent access intake escalation7.37.28.60.1-2.82.92.92.92.9-2.9-2.72.72.7-2.91.72.82.9
Intermittent access intake escalation 29.08.910.70.1-3.13.23.23.23.2-3.2-3.13.13.1-3.22.03.33.2
Intermitt. access day 1 inactive lever presses0.60.61.40.9-0.70.90.90.90.7-0.7-0.50.50.5-0.81.20.70.7
Intermitt. access day 15 inactive lever presses0.60.60.8-0.1-0.80.80.80.80.8-0.8-0.80.90.9-0.90.80.80.8
Intermitt. access escalation Index0.70.61.4-0.80.6-0.7-0.7-0.7-0.70.70.6-0.8-0.80.8-1.2-0.8-0.9
Intermittent access day 1 total infusions0.10.10.10.20.3-0.3-0.3-0.3-0.20.20.3-0.2-0.20.3-0.1-0.3-0.3
Intermittent access day 15 total infusions2.22.53.10.1-1.61.71.71.71.8-1.7-1.61.71.7-1.71.11.61.6
Intermittent access terminal intake (last 3 days)1.21.31.70.1-1.21.21.21.21.3-1.3-1.11.21.2-1.20.91.11.1
Intermittent access total infusions0.30.30.50.2-0.60.60.60.60.7-0.6-0.50.50.5-0.60.60.40.5
Intermittent access day 1 locomotion0.40.40.5-0.1-0.60.60.60.60.7-0.7-0.60.70.7-0.70.40.60.6
Intermittent access day 15 total locomotion3.43.74.6-1.0-2.12.22.22.22.1-2.1-2.02.02.0-2.10.31.81.9
Intermittent access total locomotion0.91.01.4-0.6-1.11.21.21.21.2-1.2-0.91.01.0-1.10.00.70.9
Intermittent access standard deviation3.33.54.3-0.0-2.02.12.12.12.1-2.0-1.81.91.9-2.01.41.81.9
Left kidney weight0.00.00.4-0.6-0.10.10.10.10.0-0.0-0.10.10.10.0-0.4-0.1-0.2
Right kidney weight1.23.34.1-1.1-2.01.91.91.92.0-2.0-2.02.02.0-1.90.61.81.8
Cocaine induced anxiety0.50.52.5-1.6-0.70.60.60.60.6-0.6-0.60.70.7-0.5-0.90.10.2
Post-drug Anxiety0.30.42.4-1.5-0.40.30.30.30.3-0.3-0.50.70.7-0.3-0.90.10.1
Baseline Anxiety0.30.30.90.7-0.30.30.30.30.3-0.3-0.60.60.6-0.50.90.80.7
Tail length3.19.311.0-0.7-3.33.23.23.23.3-3.3-3.33.33.3-3.31.63.23.1
Length with tail1.65.87.2-1.5-2.72.62.62.62.6-2.6-2.72.62.6-2.50.42.32.2
Length without tail0.10.31.9-1.2-0.20.10.10.10.0-0.0-0.10.00.00.2-1.4-0.3-0.3
Times rat made contact with spout0.20.21.11.10.3-0.3-0.3-0.3-0.30.30.3-0.3-0.30.20.8-0.1-0.1
Lifetime Intake0.10.10.20.1-0.30.30.30.30.5-0.4-0.20.30.3-0.30.30.20.2
Liver weight, left1.82.94.10.52.0-1.9-1.9-1.9-1.91.91.8-1.8-1.81.8-0.3-1.7-1.6
Liver weight, right1.62.73.20.11.8-1.7-1.7-1.7-1.71.71.8-1.7-1.71.8-0.9-1.8-1.7
Locomotor activity2.33.65.0-1.3-2.22.12.12.12.1-2.1-2.12.02.0-1.9-1.01.61.5
Locomotor testing distance1.42.43.3-0.6-1.81.71.71.71.8-1.8-1.71.71.7-1.6-0.51.41.4
Locomotor testing rearing0.30.54.22.1-0.30.30.30.30.3-0.3-0.40.40.4-0.41.10.50.4
Locomotion in novel chamber0.40.50.70.2-0.70.80.80.80.8-0.8-0.60.60.6-0.80.30.60.8
Locomotion in novel chamber post-restriction0.91.12.01.4-1.00.90.90.91.1-1.1-1.01.01.0-0.90.71.11.0
Fecal boli incidents, locomotor time 11.11.21.7-0.61.3-1.2-1.2-1.2-1.11.11.2-1.2-1.21.10.6-1.2-1.0
Change in fecal boli incidents, locomotor task0.20.21.21.1-0.40.30.30.30.4-0.4-0.30.30.3-0.1-0.10.3-0.0
Time >=10cm from walls, locomotor time 10.50.51.1-0.40.6-0.7-0.7-0.7-0.70.70.7-0.7-0.70.7-0.6-1.0-1.0
Bouts of movement, locomotor time 10.20.20.30.0-0.50.50.50.50.5-0.5-0.50.50.5-0.50.60.50.5
Total resting periods, locomotor time 10.20.20.30.0-0.50.50.50.50.5-0.5-0.50.50.5-0.50.30.50.5
Rest time, locomotor task time 10.10.10.2-0.4-0.40.40.40.40.5-0.5-0.40.30.3-0.4-0.40.20.2
Distance moved, locomotor task time 10.70.81.30.50.8-0.8-0.8-0.8-0.90.90.8-0.8-0.81.0-1.0-1.0-1.2
Vertical activity count, locomotor time 10.30.33.11.80.2-0.2-0.2-0.2-0.10.20.2-0.2-0.20.21.10.1-0.1
Time >=10cm from walls, locomotor time 20.90.91.41.11.0-0.9-0.9-0.9-1.01.01.0-1.0-1.00.81.2-0.8-0.8
Bouts of movement, locomotor time 20.40.43.0-1.7-0.50.40.40.40.3-0.3-0.40.30.3-0.3-1.20.20.2
Total resting periods, locomotor time 20.30.42.5-1.6-0.40.30.30.30.2-0.2-0.40.30.3-0.2-1.20.10.1
Rest time, locomotor task time 20.30.40.5-0.7-0.70.60.60.60.5-0.5-0.70.70.7-0.6-0.50.40.4
Distance moved, locomotor task time 20.50.61.01.00.8-0.8-0.8-0.8-0.80.80.8-0.8-0.80.70.3-0.7-0.6
Vertical activity count, locomotor time 20.50.51.71.20.7-0.6-0.6-0.6-0.50.50.6-0.7-0.70.51.3-0.4-0.3
Light reinforcement 14.99.010.6-3.0-3.33.23.23.23.1-3.1-3.23.23.2-3.0-0.72.82.8
Light reinforcement 21.62.23.7-1.9-1.61.51.51.51.5-1.5-1.61.51.5-1.5-0.21.31.3
Bone: marrow area0.30.60.80.80.7-0.8-0.8-0.8-0.80.80.8-0.8-0.80.8-0.6-0.8-0.9
Bone: maximum diameter0.30.50.9-0.7-0.90.70.70.70.8-0.8-0.80.80.8-0.6-0.90.50.4
Bone: maximum force1.42.43.11.21.5-1.8-1.8-1.8-1.61.61.5-1.5-1.51.6-0.1-1.5-1.7
Bone: maximum moment1.11.92.61.01.4-1.6-1.6-1.6-1.51.51.4-1.4-1.41.5-0.1-1.4-1.5
Mean time between licks in bursts4.15.87.0-0.7-2.52.62.62.62.6-2.6-2.62.62.6-2.60.82.52.5
Mean num. licks in bursts0.10.10.1-0.10.3-0.3-0.3-0.3-0.30.30.3-0.3-0.30.3-0.0-0.3-0.4
Cd content in liver0.20.20.3-0.30.5-0.5-0.5-0.5-0.50.50.5-0.5-0.50.5-0.2-0.5-0.5
Co content in liver0.60.70.9-0.4-0.90.90.90.90.9-0.9-0.90.90.9-0.90.40.80.9
Cu content in liver0.40.51.4-1.20.4-0.5-0.5-0.5-0.60.60.5-0.5-0.50.6-1.1-0.8-0.8
Fe content in liver0.10.10.6-0.2-0.20.20.20.20.3-0.3-0.30.30.3-0.30.80.40.4
K content in liver0.50.52.7-1.60.2-0.2-0.2-0.2-0.30.30.3-0.3-0.30.3-1.6-0.7-0.5
Mg content in liver0.50.53.0-1.30.2-0.2-0.2-0.2-0.40.40.3-0.3-0.30.4-1.7-0.7-0.6
Mn content in liver0.60.74.2-2.0-0.70.50.50.50.5-0.5-0.60.50.5-0.3-1.90.0-0.1
Na content in liver1.61.72.4-1.51.2-1.2-1.2-1.2-1.21.21.2-1.3-1.31.3-1.5-1.4-1.3
Rb content in liver0.81.01.8-1.00.8-0.9-0.9-0.9-0.90.91.0-1.0-1.01.1-1.4-1.2-1.2
Se content in liver0.10.20.8-0.9-0.40.40.40.40.4-0.4-0.30.30.3-0.3-0.40.30.3
Sr content in liver0.30.31.70.7-0.20.30.30.30.3-0.3-0.20.20.2-0.41.30.50.6
Zn content in liver2.83.14.30.8-1.71.91.91.91.8-1.8-1.61.71.7-1.91.62.02.1
Bone: minimum diameter0.10.10.40.60.2-0.4-0.4-0.4-0.30.30.3-0.3-0.30.4-0.6-0.4-0.5
Time in familiar zone, hab. session 12.62.43.20.6-1.51.51.51.51.6-1.6-1.71.81.8-1.61.11.81.7
Time in novel zone, hab. session 11.51.52.2-0.31.1-1.2-1.2-1.2-1.21.21.3-1.3-1.31.3-0.8-1.4-1.5
Total zone transitions, hab. session 11.01.49.8-3.1-0.90.70.70.70.7-0.7-0.80.80.8-0.7-1.90.20.3
Total locomotion distance, hab. session 11.11.510.9-3.3-0.80.60.60.60.6-0.6-0.80.80.8-0.5-2.40.10.1
Locomotion velocity, hab. session 11.52.112.9-3.6-1.11.01.01.01.0-1.0-1.11.11.1-0.8-2.40.40.5
Time in familiar zone, hab. session 26.77.08.50.0-2.72.82.82.82.8-2.8-2.82.82.8-2.81.42.92.9
Time in novel zone, hab. session 25.25.26.40.52.3-2.4-2.4-2.4-2.42.42.4-2.4-2.42.5-1.1-2.5-2.5
Total zone transitions, hab. session 22.02.516.4-4.10.7-0.9-0.9-0.9-0.80.80.7-0.7-0.70.9-3.0-1.4-1.2
Total locomotion distance, hab. session 21.31.713.2-3.6-0.80.70.70.70.7-0.7-0.80.90.9-0.6-2.20.20.4
Locomotion velocity, hab. session 21.62.118.4-4.3-0.70.60.60.60.6-0.6-0.70.70.7-0.5-2.7-0.00.2
Novel to familiar place preference ratio4.85.06.9-0.12.2-2.2-2.2-2.2-2.32.32.3-2.4-2.42.4-1.6-2.6-2.6
Novelty place preference3.13.24.6-0.31.7-1.7-1.7-1.7-1.91.91.9-1.9-1.91.9-1.4-2.1-2.1
Time in novel zone, NPP test3.33.44.8-0.01.9-1.8-1.8-1.8-2.02.02.0-2.0-2.02.0-1.2-2.1-2.2
Total zone transitions, NPP test1.11.614.3-3.80.3-0.4-0.4-0.4-0.30.30.2-0.2-0.20.3-2.4-0.8-0.5
Total locomotion distance, NPP test0.91.28.9-3.00.4-0.5-0.5-0.5-0.50.50.3-0.3-0.30.5-2.1-0.9-0.7
Locomotion velocity, NPP test0.81.110.4-3.20.1-0.2-0.2-0.2-0.20.20.0-0.0-0.00.2-2.1-0.6-0.4
Intraocular pressure0.50.63.41.3-0.30.50.50.50.5-0.5-0.40.50.5-0.61.90.90.9
Delta distance traveled before/after self-admin1.51.62.1-0.2-1.41.31.31.31.4-1.4-1.41.51.5-1.40.21.41.3
Delta ambulatory time before/after self-admin1.41.52.0-0.6-1.41.31.31.31.4-1.4-1.31.41.4-1.3-0.11.21.2
Parametrial fat weight0.51.01.21.0-1.01.01.01.01.1-1.1-1.01.01.0-1.00.91.00.9
Pavlov. Cond. lever latency0.40.53.01.1-0.30.30.30.30.4-0.4-0.40.30.3-0.51.70.60.6
Pavlov. Cond. magazine entry latency2.63.44.1-0.9-2.01.91.91.92.0-2.0-2.02.02.0-2.00.11.92.0
Pavlov. Cond. change in total contacts0.10.10.2-0.4-0.20.20.20.20.2-0.2-0.10.20.2-0.1-0.50.10.2
Pavlov. Cond. index score0.30.41.4-1.0-0.60.50.50.50.5-0.5-0.50.50.5-0.4-1.20.30.3
Pavlov. Cond. latency score0.30.42.5-1.3-0.50.40.40.40.4-0.4-0.40.40.4-0.3-1.60.10.1
Pavlov. Cond. lever contacts0.40.54.3-1.30.1-0.1-0.1-0.1-0.20.20.3-0.2-0.20.4-2.1-0.5-0.5
Pavlov. Cond. magazine entry number0.60.70.80.60.9-0.8-0.8-0.8-0.90.90.9-0.9-0.90.90.3-0.8-0.9
Pavlov. Cond. intertrial magazine entries0.30.41.20.5-0.50.40.40.40.6-0.6-0.50.50.5-0.71.10.70.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.0-0.9-0.90.80.80.80.8-0.8-0.80.80.8-0.7-1.00.60.6
Pavlov. Cond. response bias0.91.11.3-0.9-1.11.11.11.11.1-1.1-1.11.11.1-1.1-0.41.01.1
Pavlov. Cond. lever latency0.91.22.1-0.81.1-1.1-1.1-1.1-1.11.11.1-1.2-1.21.0-1.5-1.2-0.9
Pavlov. Cond. magazine entry latency0.50.61.01.0-0.80.80.80.80.7-0.7-0.80.70.7-0.70.70.80.5
Pavlov. Cond. change in total contacts0.91.21.50.6-1.11.21.21.21.1-1.1-1.11.11.1-1.11.21.21.0
Pavlov. Cond. index score1.11.42.11.2-1.21.21.21.21.1-1.1-1.21.21.2-1.11.41.31.0
Pavlov. Cond. latency score0.91.11.40.9-1.11.11.11.11.0-1.0-1.11.11.1-1.01.21.10.9
Pavlov. Cond. lever contacts1.11.53.11.2-1.11.11.11.11.1-1.1-1.11.21.2-1.11.81.31.1
Pavlov. Cond. magazine entry number0.70.91.4-1.21.0-1.0-1.0-1.0-0.90.91.0-1.0-1.00.9-0.7-1.0-0.7
Pavlov. Cond. intertrial magazine entries0.20.20.60.70.5-0.6-0.6-0.6-0.40.40.5-0.4-0.40.30.8-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.1.01.21.51.0-1.11.11.11.11.1-1.1-1.21.21.2-1.11.21.20.9
Pavlov. Cond. response bias2.22.93.61.2-1.71.71.71.71.7-1.7-1.71.81.8-1.71.91.91.6
Time in closed arm before self-admin1.61.83.7-1.51.1-1.2-1.2-1.2-1.11.11.1-1.2-1.21.3-1.9-1.5-1.4
Time in closed arm after self-admin0.00.00.00.2-0.10.00.00.00.2-0.2-0.10.10.1-0.10.20.20.2
Time in open arm before self-admin0.91.01.50.8-1.11.21.21.21.1-1.1-0.90.90.9-1.10.60.90.9
Time in open arm after self-admin0.60.61.00.50.9-0.8-0.8-0.8-1.01.00.8-0.9-0.90.80.1-0.8-0.8
Bone: periosteal estimation0.61.21.70.50.9-1.2-1.2-1.2-1.11.11.0-1.1-1.11.2-1.0-1.2-1.3
Bone: periosteal perimeter0.00.10.60.2-0.1-0.1-0.1-0.1-0.00.0-0.0-0.0-0.00.2-0.8-0.2-0.4
Bone: post-yield work0.50.71.21.10.9-1.0-1.0-1.0-0.80.80.8-0.8-0.80.80.5-0.7-0.7
Progressive ratio test 1 active lever presses0.10.10.50.60.2-0.2-0.2-0.2-0.10.10.2-0.2-0.20.20.7-0.1-0.1
Progressive ratio test 1 breakpoint0.10.10.40.60.4-0.3-0.3-0.3-0.20.30.4-0.3-0.30.30.6-0.3-0.2
Progressive ratio test 1 inactive lever presses0.00.00.0-0.2-0.10.10.10.10.1-0.10.00.00.0-0.00.1-0.1-0.0
Progressive ratio test 2 active lever presses0.40.41.00.7-0.60.70.70.70.7-0.7-0.50.50.5-0.71.00.50.6
Progressive ratio test 2 breakpoint0.30.30.50.3-0.60.70.70.70.7-0.6-0.50.50.5-0.60.60.40.5
Progressive ratio test 2 inactive lever presses0.00.00.1-0.3-0.20.20.20.20.3-0.3-0.10.20.2-0.2-0.2-0.10.0
Incentive Sensitization - Responses0.40.40.60.8-0.60.80.80.80.7-0.7-0.40.40.4-0.70.80.60.6
Incentive Sensitization - Breakpoint0.40.40.60.6-0.70.80.80.80.7-0.7-0.50.50.5-0.70.70.60.6
Sum of active levers in priming session hrs 5-60.00.00.5-0.7-0.00.10.10.10.00.00.1-0.0-0.0-0.0-0.2-0.2-0.0
Progressive ratio0.20.21.6-1.30.5-0.3-0.3-0.3-0.40.40.3-0.3-0.30.2-0.6-0.4-0.1
Food seeking constrained by brief footshock0.40.53.5-1.9-0.30.30.30.30.4-0.4-0.30.30.3-0.3-1.40.10.3
Seeking ratio, punishment vs. effort0.10.10.2-0.3-0.40.30.30.30.5-0.4-0.30.30.3-0.2-0.30.20.2
Retroperitoneal fat weight0.20.81.10.51.0-1.0-1.0-1.0-1.01.00.9-0.9-0.90.90.0-0.7-0.7
Reaction time number correct0.60.95.82.40.6-0.5-0.5-0.5-0.50.50.7-0.7-0.70.41.8-0.1-0.1
Reaction time mean minus median0.81.11.30.8-1.01.11.11.11.0-1.0-1.01.11.1-1.01.11.11.0
Reaction time mean minus median AUC0.00.10.30.20.1-0.1-0.1-0.1-0.30.30.1-0.1-0.10.3-0.5-0.3-0.5
Reaction time num false alarms0.70.99.43.10.1-0.1-0.1-0.1-0.10.10.2-0.2-0.20.11.80.30.1
Reaction time num false alarms AUC0.70.98.72.90.2-0.1-0.1-0.1-0.10.10.3-0.2-0.20.02.00.30.1
Reaction time trials correct on left0.60.95.82.40.6-0.5-0.5-0.5-0.50.50.7-0.7-0.70.41.8-0.1-0.1
Reaction time trials on left0.60.95.52.30.7-0.5-0.5-0.5-0.50.50.7-0.7-0.70.51.7-0.1-0.2
Reaction time mean0.00.00.10.30.1-0.3-0.3-0.3-0.30.20.0-0.0-0.00.20.0-0.1-0.3
Reaction time mean AUC0.10.10.20.30.2-0.3-0.3-0.3-0.30.30.1-0.1-0.10.30.0-0.2-0.5
Median of all reaction times0.30.50.80.20.7-0.8-0.8-0.8-0.80.80.6-0.6-0.60.7-0.4-0.7-0.9
Reaction time omissions0.20.20.4-0.7-0.60.60.60.60.5-0.5-0.40.40.4-0.5-0.40.30.3
Reaction time false alarm rate0.10.21.61.30.1-0.1-0.1-0.1-0.10.10.2-0.1-0.10.10.60.0-0.1
Reaction time premature initiation rate1.31.82.30.4-1.31.31.31.31.4-1.4-1.41.51.5-1.51.01.51.5
Reaction time premature initiations1.31.84.11.6-1.11.11.11.11.2-1.2-1.21.21.2-1.32.01.61.6
Std. dev. reaction times0.20.30.60.4-0.50.50.50.50.4-0.4-0.60.60.6-0.50.80.60.4
Reaction time trials completed0.60.95.52.30.7-0.5-0.5-0.5-0.50.50.7-0.7-0.70.51.7-0.1-0.2
Reaction time trials AUC0.60.96.42.50.6-0.4-0.4-0.4-0.40.40.6-0.6-0.60.42.00.0-0.0
Run reversals in cocaine runway, females0.30.30.7-0.1-0.60.50.50.50.5-0.5-0.50.50.5-0.5-0.90.40.4
Run reversals in cocaine runway, males1.01.01.6-1.3-1.00.90.90.91.1-1.1-1.01.01.0-0.9-0.90.80.9
Latency to leave start box in cocaine runway0.50.51.5-0.6-0.90.80.80.80.7-0.7-0.70.70.7-0.6-1.20.30.2
Latency to leave start box in cocaine runway, F0.60.64.1-1.20.2-0.4-0.4-0.4-0.20.30.4-0.4-0.40.5-2.0-1.0-1.0
Latency to leave start box in cocaine runway, M3.53.44.11.0-1.82.02.02.01.7-1.8-1.91.91.9-2.01.42.02.0
Std. dev. time between licks in bursts0.50.60.90.5-0.90.80.80.80.8-0.8-0.90.90.9-0.70.10.80.5
Total sessions with >9 infusions0.00.10.20.10.0-0.1-0.1-0.10.0-0.00.3-0.3-0.30.2-0.1-0.5-0.4
Short access day 1 total inactive lever presses0.10.10.5-0.7-0.20.20.20.20.3-0.3-0.10.10.1-0.10.1-0.10.1
Short access day 10 total inactive lever presses0.10.10.30.2-0.30.40.40.40.3-0.3-0.10.20.2-0.40.60.20.3
Short access day 1 total infusions0.10.10.7-0.8-0.20.10.10.10.3-0.3-0.10.20.2-0.1-0.4-0.2-0.1
Short access day 10 total infusions0.10.10.60.4-0.20.20.20.20.3-0.3-0.10.10.1-0.20.80.10.2
Short access total infusions0.00.00.1-0.00.0-0.0-0.0-0.00.1-0.10.2-0.1-0.10.10.1-0.3-0.2
Short access day 1 locomotion0.60.61.0-0.6-1.00.90.90.91.0-1.0-0.80.90.9-0.80.00.50.5
Short access day 10 total locomotion3.94.46.1-0.2-2.32.42.42.42.5-2.4-2.02.02.0-2.21.22.02.1
Short access total locomotion0.70.71.3-0.1-1.01.01.01.01.1-1.1-0.80.80.8-0.90.40.60.7
One hour access (0.3 mA shock)0.10.20.30.30.4-0.4-0.4-0.4-0.30.30.5-0.4-0.40.40.1-0.6-0.4
Compulsive drug intake1.41.41.80.01.2-1.2-1.2-1.2-1.21.21.3-1.3-1.31.3-1.0-1.3-1.3
One hour access (shock baseline)0.20.31.20.6-0.30.40.40.40.5-0.4-0.30.40.4-0.51.10.40.5
Social response proportion0.91.08.1-2.9-0.70.60.60.60.7-0.7-0.80.70.7-0.6-1.00.40.6
Social responses5.57.08.8-2.1-3.02.82.82.82.9-2.9-2.92.92.9-2.7-0.12.52.4
Social time0.60.71.1-1.00.9-0.9-0.9-0.9-0.90.80.7-0.7-0.70.8-0.8-0.9-0.8
Soleus weight7.923.227.93.15.3-5.1-5.1-5.1-5.25.25.3-5.2-5.25.1-0.1-4.7-4.7
Bone: stiffness3.14.86.21.22.3-2.5-2.5-2.5-2.32.32.3-2.3-2.32.3-0.3-2.2-2.3
Tibialis anterior weight1.13.74.91.72.0-1.8-1.8-1.8-2.12.12.2-2.2-2.22.0-0.3-1.9-1.9
Time to tail flick, vehicle, before self-admin0.40.42.6-1.6-0.50.50.50.50.4-0.4-0.40.30.3-0.3-1.20.20.2
Time to tail flick, vehicle, after self-admin0.50.62.21.0-0.40.40.40.40.4-0.5-0.70.60.6-0.61.51.01.0
Time to tail flick, test, before self-admin0.20.22.1-1.4-0.20.10.10.10.2-0.2-0.30.20.2-0.0-0.9-0.1-0.1
Time to tail flick, test, after self-admin0.20.21.6-1.3-0.30.30.30.30.3-0.3-0.50.30.3-0.2-0.80.40.4
Delta time to tail flick, vehicle, before/after SA0.60.64.12.00.4-0.4-0.4-0.4-0.30.30.2-0.1-0.10.11.70.20.2
Delta time to tail flick, test, before/after SA0.30.30.80.4-0.40.50.50.50.5-0.5-0.50.40.4-0.60.90.70.7
Tibia length1.02.73.5-0.6-1.71.81.81.81.7-1.7-1.81.91.9-1.70.61.61.6
Ambulatory time before self-admin0.40.40.8-0.30.6-0.5-0.5-0.5-0.70.70.8-0.8-0.80.6-0.5-0.9-0.8
Ambulatory time after self-admin0.30.30.5-0.7-0.70.70.70.70.6-0.6-0.40.50.5-0.6-0.30.30.3
Bone: tissue strength1.71.62.1-0.11.4-1.4-1.4-1.4-1.41.41.3-1.3-1.31.4-0.7-1.4-1.3
Total heroin consumption1.72.02.5-0.6-1.61.61.61.61.5-1.5-1.51.51.5-1.4-0.51.41.4
Bone: trabecular number0.30.52.0-1.3-0.70.70.70.70.6-0.6-0.60.50.5-0.4-1.40.20.1
Bone: trabecular spacing0.70.96.02.50.3-0.1-0.1-0.1-0.10.10.1-0.0-0.0-0.22.40.40.5
Bone: trabecular thickness1.51.711.5-2.00.4-0.7-0.7-0.7-0.70.70.6-0.7-0.71.0-3.4-1.3-1.4
Bone: trabecular tissue density1.11.62.3-0.11.5-1.5-1.5-1.5-1.41.41.4-1.3-1.31.2-0.1-1.2-1.0
Water consumed over 24 hours0.80.91.40.10.9-1.0-1.0-1.0-1.01.01.0-1.1-1.11.1-0.7-1.1-1.2
Number of responses in last shaping day0.10.10.40.1-0.40.40.40.40.6-0.6-0.20.30.3-0.30.40.10.2