Tmem97

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Tmem97	0.11	0.08	4.1e-05	0.05	0.05	0.05	0.04	1.9e-03	1.9e-03	1.1e-03	1.9e-03
2	pVTA	gene expression	Tmem97	0.06	0.05	2.4e-06	0.06	0.07	0.08	0.07	7.9e-06	4.8e-06	9.0e-07	1.2e-06
3	PL	gene expression	Tmem97	0.03	0.03	2.2e-04	0.02	0.03	0.03	0.02	2.3e-03	3.5e-04	5.8e-04	1.3e-03
4	Brain	gene expression	Tmem97	0.07	0.06	4.4e-08	0.08	0.09	0.08	0.08	4.9e-08	2.6e-08	4.5e-08	5.8e-08
5	Adipose	gene expression	Tmem97	0.1	0.08	1.6e-10	0.08	0.08	0.08	0.08	3.9e-09	3.8e-09	6.9e-09	6.7e-09
6	NAcc	gene expression	Tmem97	0.02	0.02	1.5e-03	0.01	0.01	0.01	0.01	6.6e-03	1.5e-02	1.7e-02	2.8e-02
7	IC	gene expression	Tmem97	0.07	0.07	8.1e-03	0.03	0.03	0.03	0.01	2.6e-02	3.2e-02	2.4e-02	7.9e-02
8	Liver	gene expression	Tmem97	0.04	0.05	7.1e-04	0.03	0.02	0.03	0.03	4.4e-04	1.2e-03	7.5e-04	7.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.9	3.5	3.9	1.9	1.9	-1.9	-1.9	-2.0	1.6	2.0	1.8
Area under the delay curve	0.8	1.2	1.9	-1.0	-0.9	1.1	1.2	1.3	-1.1	-1.4	-0.8
BMI with tail	1.9	6.6	8.0	2.8	2.5	-2.6	-2.6	-2.6	2.0	2.6	2.8
BMI without tail	1.1	5.7	6.5	2.5	2.3	-2.5	-2.5	-2.5	2.0	2.4	2.3
Body weight	2.7	11.9	13.1	3.6	3.4	-3.5	-3.5	-3.5	3.1	3.4	3.3
Weight adjusted by age	0.0	0.1	0.3	0.3	0.4	-0.2	-0.2	-0.3	-0.0	0.4	0.5
Bone surface	1.4	2.7	3.1	1.7	1.6	-1.7	-1.8	-1.7	1.2	1.7	1.7
Bone volume	1.2	2.5	2.7	1.6	1.6	-1.6	-1.6	-1.6	1.2	1.6	1.6
Breakpoint value in progressive ratio session	0.1	0.3	0.4	0.4	0.5	-0.5	-0.6	-0.7	0.5	0.4	0.5
Number of licking bursts	0.2	0.5	0.7	-0.7	-0.7	0.7	0.7	0.7	-0.4	-0.8	-0.8
Context. condit. distance diff. score	0.6	0.7	0.8	0.8	0.9	-0.8	-0.8	-0.9	0.7	0.9	0.8
Locomotion velocity, session 1	2.1	2.3	2.9	1.5	1.4	-1.6	-1.6	-1.6	1.7	1.4	1.3
Locomotion distance, session 1	0.2	0.2	0.4	0.5	0.0	-0.6	-0.6	-0.5	0.6	0.4	0.3
Locomotion velocity, session 2	0.0	0.0	0.1	0.2	0.1	-0.1	-0.2	-0.2	0.2	0.1	0.1
Locomotion distance, session 2	1.3	1.8	2.3	1.5	1.1	-1.3	-1.4	-1.3	1.3	1.2	1.5
Locomotion velocity, session 3	3.6	4.1	5.8	-2.0	-2.0	2.0	1.9	2.0	-2.4	-2.0	-1.8
Locomotion distance, session 3	0.4	0.5	0.9	-0.6	-0.7	0.6	0.6	0.7	-1.0	-0.7	-0.6
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.0	0.3	-0.1	-0.1	-0.1	0.0	0.0	0.1
Stereotopy head waving duration, day 3	0.6	0.8	1.0	-1.0	-0.8	0.9	0.9	0.8	-0.9	-0.9	-0.8
Locomotion velocity, session 7	0.1	0.1	0.3	0.3	0.5	-0.4	-0.4	-0.5	0.0	0.4	0.3
Locomotion distance, session 7	0.3	0.4	0.5	0.6	0.5	-0.6	-0.6	-0.7	0.4	0.7	0.6
Stereotopy head waving bouts, day 7	0.5	0.6	0.9	0.8	0.9	-0.7	-0.8	-0.8	0.6	0.8	0.9
Stereotopy head waving duration, day 7	0.2	0.2	0.3	0.4	0.5	-0.4	-0.4	-0.5	0.2	0.5	0.5
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	0.2	-0.3	-0.3	-0.2	0.2	0.1	0.3
Locomotion distance, session 8	0.8	1.2	1.5	1.2	1.0	-1.1	-1.1	-1.1	1.0	1.1	1.2
Degree of sensitization distance	3.0	3.2	3.8	1.7	1.9	-1.7	-1.7	-1.8	2.0	1.8	1.7
Degree of sensitization stereotypy	0.6	0.6	0.8	0.8	0.8	-0.8	-0.8	-0.8	0.7	0.8	0.9
Conditioned locomotion	1.8	2.1	2.3	-1.4	-1.5	1.5	1.4	1.5	-1.5	-1.5	-1.3
Cocaine response after cond. corrected	1.4	2.1	2.5	1.5	1.4	-1.4	-1.4	-1.4	1.6	1.4	1.4
Cocaine response after cond. not corrected	1.9	2.7	3.0	1.7	1.6	-1.7	-1.7	-1.6	1.7	1.6	1.7
Cocaine response before conditioning	0.1	0.2	0.2	0.5	0.3	-0.5	-0.5	-0.5	0.1	0.4	0.4
Saline control response	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.0	-0.3	-0.1	-0.1
Bone: connectivity density	3.4	5.5	6.1	2.4	2.3	-2.4	-2.5	-2.5	1.9	2.4	2.3
Bone: cortical apparent density	0.4	0.7	1.0	-1.0	-0.6	0.9	0.9	0.8	-0.4	-0.9	-1.0
Bone: cortical area	1.3	2.1	2.8	-1.4	-1.3	1.4	1.4	1.5	-1.7	-1.4	-1.4
Bone: cortical porosity	0.2	0.2	0.4	0.4	0.4	-0.4	-0.4	-0.6	0.2	0.6	0.3
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.2	-0.3	-0.3	-0.4	-0.0	0.4	0.2
Bone: cortical thickness	2.9	4.8	5.6	-2.2	-2.0	2.2	2.2	2.2	-2.4	-2.1	-2.2
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.5	0.3	0.2	0.2	-0.4	-0.3	-0.4
Bone: cortical tissue density	0.3	0.4	0.6	-0.8	-0.4	0.7	0.7	0.6	-0.2	-0.7	-0.8
Condit. Reinf. active minus inactive responses	0.9	1.0	1.5	-1.0	-1.0	1.0	1.0	0.9	-1.2	-1.0	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.5	-0.6	0.4	0.5	0.4	-0.9	-0.5	-0.4
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.1	-0.2	-0.2	-0.2
Condit. Reinf. inactive responses	0.4	0.5	1.2	0.6	0.8	-0.6	-0.7	-0.6	1.1	0.5	0.6
Incentive salience index mean	0.3	0.4	0.9	-0.5	-0.6	0.6	0.6	0.6	-1.0	-0.6	-0.4
Condit. Reinf. lever presses	0.1	0.2	0.4	0.5	0.6	-0.4	-0.4	-0.4	-0.0	0.4	0.6
Condit. Reinf. active minus inactive responses	0.6	0.9	1.5	-1.0	-1.2	0.9	0.9	0.8	-0.9	-0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.5	0.8	1.4	-0.9	-1.2	0.9	0.9	0.9	-0.8	-0.9	-0.8
Condit. Reinf. active responses	0.4	0.6	0.9	-0.8	-0.9	0.7	0.7	0.6	-0.8	-0.7	-0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.0	-0.1	-0.3	0.1	-0.0
Condit. Reinf. lever presses	2.5	3.7	4.6	-1.9	-2.2	1.9	1.9	1.9	-1.9	-1.9	-1.7
Condit. Reinf. lever reinforcers received	0.7	1.0	1.4	-1.0	-1.2	1.0	0.9	0.9	-1.0	-0.9	-0.9
Conditioned reinforcement - actives	0.1	0.4	0.5	0.7	0.7	-0.7	-0.7	-0.7	0.5	0.7	0.7
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.5	0.4	-0.5	-0.5	-0.4	0.5	0.4	0.2
Conditioned locomotion	0.6	0.8	1.6	1.0	1.0	-0.9	-0.8	-0.7	0.6	0.8	1.3
Patch foraging indifference point 0 sec	0.4	1.0	1.6	-1.0	-1.1	0.9	0.9	0.9	-1.3	-0.9	-0.9
Patch foraging indifference point AUC	1.3	3.0	3.5	-1.7	-1.9	1.8	1.7	1.8	-1.6	-1.8	-1.6
Delay disc. indifference point, 0s delay	0.7	0.7	1.1	-0.7	-1.1	0.9	0.9	0.9	-1.0	-0.9	-0.5
Delay disc. indifference point, 16s delay	0.4	0.5	1.1	-0.6	-0.3	0.8	0.8	1.0	-0.5	-1.0	-0.4
Delay disc. indifference point, 2s delay	2.4	2.6	3.0	-1.6	-1.6	1.7	1.7	1.7	-1.6	-1.7	-1.4
Delay disc. indifference point, 24s delay	0.5	0.8	1.1	0.9	1.0	-0.9	-0.9	-0.9	0.9	0.8	0.9
Delay disc. indifference point, 4s delay	0.1	0.2	0.3	-0.4	-0.1	0.3	0.4	0.4	-0.3	-0.5	-0.6
Delay disc. indifference point, 8s delay	0.3	0.6	0.9	-0.6	-0.5	0.8	0.8	1.0	-0.8	-1.0	-0.3
Indifference point function ln k	0.3	0.8	1.2	0.8	1.1	-0.9	-0.8	-1.0	0.9	0.9	0.5
Indifference point function log k	0.3	0.8	1.2	0.8	1.1	-0.9	-0.8	-1.0	0.9	0.9	0.5
Patch foraging total patch changes 0 sec	0.3	0.8	1.4	-0.9	-1.0	0.8	0.8	0.8	-1.2	-0.8	-0.9
Patch foraging total patch changes 12 sec	0.2	0.2	0.6	-0.4	-0.8	0.4	0.4	0.5	-0.5	-0.5	-0.4
Patch foraging total patch changes 18 sec	1.2	2.8	3.7	-1.7	-1.9	1.6	1.6	1.6	-1.6	-1.7	-1.6
Patch foraging total patch changes 24 sec	1.1	3.6	4.7	-1.9	-2.2	1.9	1.8	1.9	-1.9	-1.9	-1.7
Patch foraging total patch changes 6 sec	2.9	4.9	6.0	-2.1	-2.5	2.2	2.2	2.3	-2.3	-2.2	-1.9
Patch foraging time to switch 0 sec	0.8	2.9	3.3	1.7	1.8	-1.7	-1.7	-1.6	1.7	1.6	1.7
Patch foraging water rate 0 sec	0.9	3.5	4.5	-1.9	-2.1	1.8	1.8	1.8	-1.8	-1.8	-1.8
Patch foraging water rate 12 sec	0.0	0.2	0.3	0.2	0.4	-0.4	-0.4	-0.5	0.6	0.6	0.2
Patch foraging water rate 18 sec	0.3	0.8	1.1	0.8	0.9	-0.8	-0.8	-0.9	1.1	0.9	0.8
Patch foraging water rate 24 sec	0.2	0.2	0.4	-0.4	-0.6	0.4	0.4	0.5	-0.5	-0.5	-0.5
Patch foraging water rate 6 sec	1.2	1.7	2.3	-1.4	-1.3	1.3	1.3	1.2	-1.1	-1.3	-1.5
Seeking ratio, delayed vs. immediate footshock	1.5	2.1	2.7	-1.4	-1.6	1.4	1.5	1.5	-1.6	-1.4	-1.3
Distance traveled before self-admin	2.0	4.5	5.3	-2.2	-2.0	2.2	2.2	2.2	-2.3	-1.7	-2.2
Distance traveled after self-admin	0.0	0.1	0.1	-0.2	-0.0	0.3	0.3	0.3	-0.3	-0.1	-0.2
Extensor digitorum longus weight	0.8	3.3	4.3	1.9	1.8	-1.8	-1.8	-1.8	1.4	1.8	2.1
Bone: elastic displacement	2.7	3.5	3.7	-1.9	-1.8	1.9	1.9	1.9	-1.9	-1.9	-1.8
Bone: elastic work	9.3	12.2	14.7	-3.5	-3.5	3.4	3.4	3.4	-3.8	-3.4	-3.6
Bone: endosteal estimation	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	-0.1	-0.0	0.1
Bone: endosteal perimeter	0.0	0.1	0.2	0.4	0.1	-0.3	-0.3	-0.2	0.2	0.2	0.3
Epididymis fat weight	5.9	29.6	31.0	5.5	5.6	-5.4	-5.4	-5.4	5.6	5.4	5.3
Delta time in closed arm before/after self-admin	3.0	2.9	3.4	-1.8	-1.3	1.8	1.8	1.7	-1.4	-1.7	-1.8
Delta time in open arm before/after self-admin	5.4	6.4	7.8	2.8	1.9	-2.7	-2.7	-2.6	2.2	2.5	2.7
Diff in mean of infusions in LGA sessions	0.4	0.7	0.9	0.9	0.7	-0.9	-0.9	-0.8	0.8	0.7	0.9
Delay discount exponential model param	0.6	0.9	1.4	0.8	0.7	-0.9	-1.0	-1.1	1.0	1.2	0.7
Extinction: sum of active levers before priming	0.6	0.9	1.0	1.0	0.8	-1.0	-1.0	-1.0	0.7	0.9	1.0
Active lever presses in extinction session 6	0.1	0.1	0.4	0.1	0.1	-0.2	-0.3	-0.4	-0.1	0.6	0.2
Bone: final force	0.4	0.6	2.0	-0.6	-0.8	0.6	0.6	0.7	-1.4	-0.6	-0.7
Bone: final moment	0.4	0.7	2.2	-0.7	-0.8	0.6	0.7	0.7	-1.5	-0.7	-0.8
Food consumed during 24 hour testing period	0.3	0.6	0.9	-0.9	-0.7	0.7	0.7	0.5	-0.8	-0.7	-1.0
Glucose	1.3	2.1	2.3	-1.5	-1.4	1.5	1.5	1.5	-1.2	-1.5	-1.4
Heart weight	1.2	1.9	2.4	1.4	1.3	-1.5	-1.5	-1.5	1.0	1.3	1.3
Delay discount hyperbolic model param	1.1	1.4	1.9	1.1	1.0	-1.2	-1.2	-1.3	1.3	1.4	0.9
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.1	-0.2	0.1	0.2	-0.0
Intermittent access intake escalation	0.0	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.4	0.2	0.4	0.2
Intermittent access intake escalation 2	0.1	0.2	0.3	-0.5	-0.4	0.4	0.4	0.4	-0.3	-0.3	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	-0.4	-0.5	0.3	0.3	0.4	-0.6	-0.5	-0.4
Intermitt. access day 15 inactive lever presses	0.2	0.8	1.6	-0.9	-1.2	0.8	0.8	0.8	-0.5	-1.0	-0.9
Intermitt. access escalation Index	0.6	1.8	2.5	1.4	1.5	-1.2	-1.1	-1.1	1.5	1.3	1.6
Intermittent access day 1 total infusions	0.2	0.5	1.2	0.9	0.6	-0.7	-0.7	-0.5	0.6	0.4	1.1
Intermittent access day 15 total infusions	0.6	1.5	2.4	1.3	1.0	-1.3	-1.2	-1.2	1.1	1.1	1.6
Intermittent access terminal intake (last 3 days)	1.0	1.7	2.2	1.4	1.2	-1.3	-1.3	-1.2	1.3	1.2	1.5
Intermittent access total infusions	0.6	0.7	1.7	1.0	0.6	-0.8	-0.8	-0.7	0.6	0.7	1.3
Intermittent access day 1 locomotion	0.1	0.2	0.6	0.5	0.3	-0.4	-0.3	-0.2	0.1	0.2	0.8
Intermittent access day 15 total locomotion	0.2	0.7	1.2	0.9	0.8	-0.8	-0.8	-0.8	0.6	0.8	1.1
Intermittent access total locomotion	0.7	0.9	1.6	1.1	0.8	-1.0	-1.0	-0.9	0.6	0.8	1.3
Intermittent access standard deviation	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.0	0.3	0.1	0.3
Left kidney weight	0.0	0.2	0.3	0.5	0.4	-0.5	-0.5	-0.5	0.2	0.4	0.4
Right kidney weight	0.1	0.8	0.9	0.9	0.8	-0.9	-0.9	-0.9	0.7	0.9	0.9
Cocaine induced anxiety	0.1	0.2	0.4	-0.4	-0.6	0.4	0.4	0.4	-0.4	-0.5	-0.3
Post-drug Anxiety	0.1	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.4	0.4	0.3	0.3
Baseline Anxiety	0.1	0.2	0.3	0.2	0.4	-0.4	-0.4	-0.5	0.5	0.5	0.2
Tail length	0.3	1.4	1.9	1.1	1.2	-1.2	-1.2	-1.3	1.4	1.2	0.8
Length with tail	0.5	2.4	3.0	1.5	1.6	-1.6	-1.6	-1.6	1.7	1.5	1.2
Length without tail	0.3	1.5	1.9	1.3	1.3	-1.2	-1.2	-1.1	1.4	1.2	1.1
Times rat made contact with spout	0.2	0.2	0.6	-0.4	-0.4	0.3	0.3	0.2	-0.7	-0.4	-0.6
Lifetime Intake	0.8	1.0	1.8	1.2	0.8	-1.0	-1.0	-0.9	0.8	0.9	1.4
Liver weight, left	5.1	8.8	10.0	2.9	3.1	-2.9	-2.9	-2.9	3.2	2.9	2.8
Liver weight, right	4.0	7.0	7.4	2.7	2.7	-2.7	-2.7	-2.7	2.6	2.6	2.6
Locomotor activity	0.0	0.1	0.3	-0.2	-0.5	0.2	0.2	0.2	-0.0	-0.2	-0.2
Locomotor testing distance	0.0	0.1	0.3	-0.3	-0.5	0.3	0.3	0.3	-0.0	-0.3	-0.2
Locomotor testing rearing	0.1	0.2	0.4	-0.5	-0.6	0.4	0.4	0.3	-0.0	-0.5	-0.5
Locomotion in novel chamber	1.8	2.5	3.2	-1.6	-1.4	1.7	1.7	1.8	-1.6	-1.3	-1.5
Locomotion in novel chamber post-restriction	0.0	0.0	0.2	-0.0	0.5	-0.0	-0.0	-0.0	-0.1	0.3	-0.2
Fecal boli incidents, locomotor time 1	0.8	2.0	2.4	1.4	1.4	-1.4	-1.4	-1.4	1.4	1.5	1.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.1	-0.1	0.1	0.2	0.3	-0.3	-0.4	-0.2
Time >=10cm from walls, locomotor time 1	0.0	0.1	0.2	0.2	-0.0	-0.2	-0.2	-0.2	-0.4	0.2	0.3
Bouts of movement, locomotor time 1	0.4	0.5	0.5	-0.7	-0.7	0.7	0.7	0.7	-0.7	-0.7	-0.6
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.4	-0.4	0.4	0.4	0.4	-0.3	-0.3	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.3	0.2	0.0	-0.3	-0.3	-0.4	-0.0	0.6	-0.0
Distance moved, locomotor task time 1	0.1	0.2	0.4	-0.4	-0.4	0.5	0.5	0.6	-0.5	-0.7	-0.4
Vertical activity count, locomotor time 1	0.0	0.0	0.2	0.0	-0.1	0.1	0.1	0.3	-0.3	-0.4	0.2
Time >=10cm from walls, locomotor time 2	0.4	1.1	1.6	1.2	0.7	-1.2	-1.2	-1.1	0.2	1.0	1.3
Bouts of movement, locomotor time 2	0.2	0.6	1.3	-0.9	-0.7	0.7	0.7	0.7	-0.5	-0.8	-1.1
Total resting periods, locomotor time 2	0.1	0.3	0.8	-0.6	-0.4	0.4	0.4	0.3	-0.3	-0.5	-0.9
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.5	-0.5	0.4	0.3	0.1	-0.2	-0.1	-0.5
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	-0.0	0.3	0.3	0.5	-0.1	-0.5	0.0
Vertical activity count, locomotor time 2	0.0	0.1	0.3	0.1	-0.0	0.2	0.2	0.5	-0.2	-0.5	0.1
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.0	0.1	0.1	0.1	-0.0	-0.1	0.2
Light reinforcement 2	0.2	0.5	0.5	-0.7	-0.6	0.7	0.7	0.7	-0.7	-0.7	-0.7
Bone: marrow area	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	-0.1	-0.0	0.0
Bone: maximum diameter	0.3	0.5	1.0	-0.6	-0.7	0.6	0.6	0.8	-1.0	-0.7	-0.6
Bone: maximum force	0.5	1.0	2.1	-0.8	-1.0	0.8	0.9	0.9	-1.4	-0.9	-0.9
Bone: maximum moment	0.6	1.1	2.3	-0.9	-1.1	0.9	0.9	1.0	-1.5	-1.0	-1.0
Mean time between licks in bursts	0.2	1.1	1.6	1.1	1.3	-1.0	-1.0	-1.0	1.1	0.9	0.9
Mean num. licks in bursts	0.1	0.3	0.5	0.6	0.5	-0.6	-0.6	-0.7	0.1	0.7	0.5
Cd content in liver	0.5	0.6	0.8	-0.7	-0.9	0.8	0.8	0.9	-0.3	-0.9	-0.6
Co content in liver	0.4	0.5	0.9	-0.6	-1.0	0.7	0.7	0.7	-0.9	-0.7	-0.3
Cu content in liver	2.0	2.3	2.9	-1.5	-1.7	1.5	1.5	1.4	-1.5	-1.5	-1.5
Fe content in liver	2.2	2.7	3.0	1.6	1.6	-1.7	-1.7	-1.6	1.7	1.4	1.6
K content in liver	0.1	0.1	0.2	0.5	0.3	-0.4	-0.3	-0.3	0.2	0.2	0.4
Mg content in liver	0.8	0.9	1.2	-0.9	-1.1	0.8	0.8	0.8	-1.1	-1.1	-1.0
Mn content in liver	0.3	0.3	0.3	-0.5	-0.6	0.6	0.6	0.5	-0.5	-0.6	-0.5
Na content in liver	0.2	0.3	0.6	0.7	0.3	-0.5	-0.4	-0.3	0.8	0.2	0.6
Rb content in liver	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.3	0.2	0.2	0.4
Se content in liver	0.8	0.9	1.2	-1.0	-1.1	0.8	0.8	0.9	-1.0	-1.1	-1.0
Sr content in liver	0.3	0.3	0.4	0.5	0.5	-0.5	-0.5	-0.6	0.6	0.7	0.5
Zn content in liver	0.3	0.3	0.5	0.5	0.4	-0.7	-0.7	-0.7	0.5	0.5	0.4
Bone: minimum diameter	0.0	0.1	0.1	-0.2	-0.2	0.3	0.2	0.4	-0.3	-0.3	-0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.5	-0.5	0.5	0.6	0.6	-0.4	-0.4	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.2	0.3	-0.4	-0.4	-0.4	0.4	0.3	0.2
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.0	-0.0	0.1	0.1	0.2	0.2	-0.2	0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.4	-0.2	0.4	0.4	0.4	0.0	-0.4	-0.4
Locomotion velocity, hab. session 1	0.3	0.4	0.5	-0.6	-0.6	0.7	0.7	0.7	-0.4	-0.7	-0.7
Time in familiar zone, hab. session 2	0.2	0.3	0.4	-0.6	-0.6	0.5	0.5	0.4	-0.4	-0.5	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.2	-0.1	0.2	0.2	0.3	-0.3	-0.2	-0.3
Total zone transitions, hab. session 2	0.4	0.5	0.8	0.8	0.6	-0.6	-0.6	-0.6	0.8	0.6	0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.2	-0.5	0.3	0.3	0.3	-0.1	-0.4	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.3	-0.5	0.4	0.4	0.4	-0.1	-0.4	-0.2
Novel to familiar place preference ratio	0.7	1.0	1.0	1.0	1.0	-1.0	-1.0	-1.0	0.9	1.0	1.0
Novelty place preference	1.0	1.3	1.4	1.1	1.1	-1.1	-1.1	-1.1	1.1	1.2	1.1
Time in novel zone, NPP test	1.1	1.3	1.4	1.1	1.2	-1.2	-1.2	-1.2	1.1	1.2	1.1
Total zone transitions, NPP test	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.2	-0.1	0.3	0.0	0.3
Total locomotion distance, NPP test	0.9	1.2	1.7	-1.0	-1.3	1.1	1.1	1.1	-0.8	-1.2	-1.0
Locomotion velocity, NPP test	1.0	1.4	2.0	-1.1	-1.4	1.2	1.2	1.2	-0.9	-1.3	-1.1
Intraocular pressure	0.9	1.5	1.8	-1.3	-1.0	1.3	1.3	1.3	-1.0	-1.2	-1.2
Delta distance traveled before/after self-admin	2.8	3.1	3.6	1.9	1.6	-1.8	-1.8	-1.8	1.6	1.6	1.9
Delta ambulatory time before/after self-admin	1.5	2.6	3.2	1.8	1.3	-1.7	-1.7	-1.6	1.7	1.2	1.8
Parametrial fat weight	6.2	14.6	15.4	3.8	3.9	-3.8	-3.8	-3.8	3.9	3.7	3.8
Pavlov. Cond. lever latency	0.0	0.0	0.2	-0.0	0.0	-0.0	-0.0	-0.1	0.4	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	0.1	-0.2	-0.2	-0.1	0.0	0.1	0.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.4	-0.5	0.6	0.6	0.6	-0.7	-0.6	-0.3
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	-0.1	0.1	0.0	0.1	-0.4	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	0.0	-0.2	0.0	0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	0.0	-0.2	0.1	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.2	0.3	-0.3	-0.3	-0.4	0.4	0.4	0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.4	-0.6	-0.6	0.6	0.5	0.5	-0.4	-0.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	-0.0	-0.3	0.2	0.2	0.3	-0.5	-0.2	0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.1	-0.2	-0.0	0.2
Pavlov. Cond. lever latency	2.5	3.5	4.4	1.9	2.1	-1.9	-1.9	-1.9	1.6	1.9	1.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	-0.5	-0.5	0.5	0.5	0.5	-0.5	-0.6	-0.6
Pavlov. Cond. change in total contacts	0.9	2.3	3.1	-1.5	-1.8	1.5	1.5	1.5	-1.5	-1.5	-1.5
Pavlov. Cond. index score	2.0	3.2	3.9	-1.8	-2.0	1.8	1.8	1.8	-1.6	-1.9	-1.8
Pavlov. Cond. latency score	2.4	3.8	4.7	-2.0	-2.2	1.9	1.9	1.9	-1.7	-2.0	-1.9
Pavlov. Cond. lever contacts	1.5	2.2	2.9	-1.5	-1.7	1.5	1.4	1.4	-1.3	-1.5	-1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.1	0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.7	0.9	0.8	0.9	-0.8	-0.8	-0.8	0.9	0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.4	3.1	-1.6	-1.8	1.5	1.5	1.5	-1.4	-1.6	-1.5
Pavlov. Cond. response bias	1.2	1.6	2.0	-1.3	-1.4	1.3	1.3	1.3	-1.0	-1.3	-1.3
Time in closed arm before self-admin	1.4	2.4	2.6	1.6	1.5	-1.5	-1.5	-1.4	1.6	1.6	1.6
Time in closed arm after self-admin	0.3	0.3	0.7	-0.6	-0.0	0.7	0.7	0.8	-0.0	-0.5	-0.7
Time in open arm before self-admin	2.3	2.8	3.3	-1.8	-1.6	1.7	1.7	1.5	-1.7	-1.7	-1.8
Time in open arm after self-admin	0.7	0.8	1.1	1.0	0.3	-1.0	-1.0	-1.0	0.5	0.8	1.0
Bone: periosteal estimation	0.3	0.7	1.1	-0.7	-0.9	0.7	0.7	0.9	-1.0	-0.8	-0.8
Bone: periosteal perimeter	0.1	0.3	0.5	-0.4	-0.5	0.5	0.5	0.6	-0.7	-0.6	-0.5
Bone: post-yield work	0.3	0.6	0.9	0.8	0.9	-0.7	-0.7	-0.6	0.6	0.7	0.9
Progressive ratio test 1 active lever presses	0.2	0.3	0.5	-0.4	-0.7	0.6	0.6	0.7	-0.6	-0.7	-0.3
Progressive ratio test 1 breakpoint	0.2	0.4	0.6	-0.5	-0.8	0.7	0.7	0.7	-0.7	-0.7	-0.3
Progressive ratio test 1 inactive lever presses	0.6	1.5	1.9	-1.1	-1.2	1.2	1.3	1.4	-1.3	-1.3	-1.0
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	-0.5	-0.7	0.6	0.6	0.6	-0.8	-0.6	-0.3
Progressive ratio test 2 breakpoint	0.3	0.4	0.6	-0.5	-0.7	0.5	0.5	0.6	-0.8	-0.6	-0.3
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.3	-0.4	-0.5	0.3	0.3	0.3	-0.5	-0.3	-0.3
Incentive Sensitization - Responses	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.1	-0.1	-0.3	-0.0	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.2	-0.2	-0.2	0.0	0.2
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.5	1.2	0.8	-1.2	-1.2	-1.2	0.7	1.0	1.2
Progressive ratio	0.0	0.1	0.5	-0.1	-0.3	0.0	-0.0	-0.1	-0.7	0.2	-0.2
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	0.3	-0.3	-0.3	-0.3	0.5	0.3	0.2
Seeking ratio, punishment vs. effort	0.0	0.1	0.4	0.0	0.3	0.1	0.1	0.2	0.6	-0.2	0.1
Retroperitoneal fat weight	0.6	2.9	4.6	1.7	1.8	-1.6	-1.6	-1.5	2.2	1.6	1.6
Reaction time number correct	0.4	1.3	1.5	1.2	0.9	-1.1	-1.1	-1.2	1.0	1.2	1.1
Reaction time mean minus median	0.1	0.3	0.8	0.5	0.6	-0.5	-0.5	-0.5	0.9	0.6	0.4
Reaction time mean minus median AUC	0.4	2.8	4.3	1.6	1.7	-1.6	-1.6	-1.5	2.1	1.6	1.5
Reaction time num false alarms	4.9	8.3	9.0	-2.9	-2.9	2.9	2.9	2.9	-3.0	-2.8	-2.8
Reaction time num false alarms AUC	3.8	8.6	9.9	-2.9	-2.9	3.0	3.0	2.9	-3.1	-2.8	-2.8
Reaction time trials correct on left	0.4	1.3	1.5	1.2	0.9	-1.1	-1.1	-1.2	1.0	1.2	1.1
Reaction time trials on left	0.4	1.3	1.6	1.2	0.9	-1.2	-1.2	-1.2	1.1	1.2	1.1
Reaction time mean	0.5	1.0	2.2	0.9	1.0	-1.0	-1.0	-1.0	1.5	0.9	0.7
Reaction time mean AUC	0.3	0.8	1.7	0.8	0.9	-0.9	-0.9	-0.9	1.3	0.8	0.6
Median of all reaction times	0.4	0.7	1.7	0.7	0.8	-0.8	-0.8	-0.8	1.3	0.7	0.5
Reaction time omissions	1.3	2.1	3.0	1.4	1.7	-1.4	-1.4	-1.4	1.4	1.5	1.4
Reaction time false alarm rate	6.3	8.8	9.8	-3.0	-2.9	3.0	3.0	2.9	-3.1	-2.9	-2.9
Reaction time premature initiation rate	0.2	0.3	0.5	0.6	0.7	-0.6	-0.6	-0.5	0.5	0.6	0.6
Reaction time premature initiations	0.2	0.7	0.7	0.9	0.9	-0.8	-0.8	-0.8	0.8	0.9	0.8
Std. dev. reaction times	0.4	1.3	2.0	1.0	1.2	-1.1	-1.1	-1.1	1.4	1.1	1.0
Reaction time trials completed	0.4	1.3	1.6	1.2	0.9	-1.2	-1.2	-1.2	1.1	1.2	1.1
Reaction time trials AUC	0.3	1.0	1.3	1.1	0.8	-1.0	-1.0	-1.1	0.9	1.1	1.0
Run reversals in cocaine runway, females	0.1	0.2	0.6	0.3	0.4	-0.2	-0.3	-0.3	0.8	0.3	0.3
Run reversals in cocaine runway, males	0.1	0.2	0.4	0.4	0.7	-0.3	-0.3	-0.2	0.5	0.4	0.3
Latency to leave start box in cocaine runway	0.9	1.2	2.1	-1.2	-1.4	1.0	0.9	0.7	-1.5	-0.7	-1.2
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	-0.6	-0.7	0.5	0.4	0.2	-0.7	-0.4	-0.4
Latency to leave start box in cocaine runway, M	0.6	0.6	1.2	-0.9	-0.9	0.6	0.6	0.4	-1.1	-0.1	-1.0
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.3	0.2	-0.2	-0.2	-0.2	0.2	0.1	0.1
Total sessions with >9 infusions	0.7	0.8	1.2	1.1	1.0	-0.9	-0.9	-0.7	0.8	0.8	1.1
Short access day 1 total inactive lever presses	2.7	5.3	5.9	2.4	2.3	-2.3	-2.3	-2.2	2.1	2.4	2.4
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.0	-0.1	-0.0	0.0	0.1	-0.2	0.0	-0.2
Short access day 1 total infusions	0.6	1.1	1.6	1.3	0.8	-1.2	-1.1	-0.9	1.0	1.0	1.2
Short access day 10 total infusions	0.4	0.7	1.0	1.0	0.8	-0.9	-0.8	-0.7	1.0	0.7	0.9
Short access total infusions	0.3	0.5	0.8	0.9	0.6	-0.7	-0.7	-0.5	0.7	0.6	0.9
Short access day 1 locomotion	0.0	0.0	0.2	0.3	-0.1	-0.1	-0.1	0.1	-0.0	0.0	0.4
Short access day 10 total locomotion	0.2	0.7	1.3	-0.7	-1.1	0.7	0.8	0.8	-1.0	-0.9	-0.6
Short access total locomotion	0.2	0.3	0.5	-0.3	-0.7	0.5	0.5	0.7	-0.7	-0.7	-0.1
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.0	-0.2	0.1	0.1	0.2	-0.2	-0.2	0.2
Compulsive drug intake	0.8	1.2	1.4	1.1	1.0	-1.1	-1.1	-1.1	1.1	1.1	1.2
One hour access (shock baseline)	0.0	0.1	0.1	-0.3	-0.3	0.4	0.4	0.4	-0.3	-0.4	-0.1
Social response proportion	2.3	2.9	3.4	1.8	1.7	-1.8	-1.8	-1.7	1.5	1.7	1.7
Social responses	1.9	2.5	2.8	1.6	1.4	-1.6	-1.6	-1.6	1.5	1.7	1.5
Social time	1.6	2.5	3.3	1.7	1.6	-1.6	-1.6	-1.5	1.4	1.6	1.8
Soleus weight	2.4	7.0	7.5	2.7	2.7	-2.7	-2.7	-2.6	2.4	2.6	2.7
Bone: stiffness	1.7	3.0	3.4	1.8	1.6	-1.8	-1.8	-1.8	1.5	1.8	1.8
Tibialis anterior weight	2.7	9.4	10.2	3.2	3.0	-3.1	-3.1	-3.1	2.6	3.1	3.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.5	0.7	-0.4	-0.4	-0.3	0.4	0.5	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.5	-0.5	-0.7	0.6	0.6	0.7	-0.5	-0.7	-0.5
Time to tail flick, test, before self-admin	0.0	0.0	0.2	-0.1	0.3	-0.0	-0.0	-0.1	0.4	0.2	-0.1
Time to tail flick, test, after self-admin	0.9	1.0	1.6	-1.3	-0.8	1.0	0.9	0.7	-0.8	-0.9	-1.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.7	1.0	-0.9	-1.0	0.8	0.7	0.7	-0.7	-1.0	-0.9
Delta time to tail flick, test, before/after SA	0.6	0.7	1.0	-0.8	-1.0	0.8	0.8	0.7	-0.8	-0.9	-0.8
Tibia length	0.0	0.0	0.1	-0.1	0.0	0.2	0.2	0.2	-0.2	-0.2	-0.2
Ambulatory time before self-admin	0.5	1.6	2.1	-1.2	-0.9	1.4	1.4	1.4	-1.4	-0.9	-1.2
Ambulatory time after self-admin	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1	-0.0	0.0	0.2	0.2
Bone: tissue strength	1.6	1.7	2.7	-1.2	-1.0	1.3	1.3	1.3	-1.6	-1.3	-1.3
Total heroin consumption	2.3	2.7	3.7	1.5	1.7	-1.7	-1.7	-1.9	1.4	1.7	1.5
Bone: trabecular number	2.4	4.6	5.1	2.1	2.2	-2.2	-2.2	-2.3	2.0	2.2	2.0
Bone: trabecular spacing	0.2	0.3	0.6	-0.5	-0.5	0.6	0.6	0.6	-0.7	-0.5	-0.4
Bone: trabecular thickness	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.0	0.0	-0.1	-0.1	-0.1
Bone: trabecular tissue density	1.0	1.8	2.0	-1.4	-1.4	1.4	1.4	1.4	-1.0	-1.4	-1.4
Water consumed over 24 hours	0.0	0.1	0.2	-0.3	-0.4	0.2	0.2	0.2	-0.3	-0.3	-0.4
Number of responses in last shaping day	0.9	1.2	1.4	-1.0	-1.1	1.0	1.1	1.2	-1.1	-1.1	-1.1