Hub : Genes

Tmem259

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	Tmem259	0.28	0.19	6.0e-03	0.09	0.04	0.01	0.05	1.8e-02	9.4e-02	2.2e-01	6.2e-02
2	PL	isoform ratio	NM_001100886.1	0.02	0.02	4.6e-03	0.01	0.02	0	0.01	8.4e-03	5.2e-03	2.4e-01	1.2e-02
3	PL	isoform ratio	XM_039078644.1	0.03	0.02	5.7e-04	0.01	0.02	0.02	0.02	9.8e-03	1.4e-03	2.6e-03	4.3e-03
4	Eye	alternative TSS	NM_001100886.1	0.74	0.16	2.4e-03	0.02	0.02	0.07	0.06	1.5e-01	1.5e-01	3.6e-02	5.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.9	1.5	5.3	0.9	0.0	0.1	2.3
Area under the delay curve	2.1	2.2	2.9	-1.7	-1.7	1.7	0.7
BMI with tail	5.6	18.2	24.1	-4.7	-4.9	4.9	1.5
BMI without tail	2.3	4.8	7.2	-2.7	-2.5	2.4	-0.5
Body weight	1.0	4.3	5.7	-2.3	-2.4	2.4	0.7
Weight adjusted by age	0.9	1.0	1.7	-1.3	-0.9	0.8	-1.0
Bone surface	1.8	3.2	8.5	1.8	0.8	-0.6	2.9
Bone volume	1.7	3.0	8.3	1.7	0.6	-0.5	2.9
Breakpoint value in progressive ratio session	4.6	5.1	6.5	2.1	2.5	-2.5	-1.7
Number of licking bursts	0.5	0.5	1.2	-0.9	-0.4	0.3	-1.1
Context. condit. distance diff. score	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.1
Locomotion velocity, session 1	0.8	0.9	1.5	1.2	0.8	-0.8	0.9
Locomotion distance, session 1	2.0	2.6	5.2	1.9	0.9	-0.7	2.3
Locomotion velocity, session 2	5.6	6.6	11.5	3.4	2.6	-2.5	1.2
Locomotion distance, session 2	2.9	4.1	6.5	2.5	1.7	-1.7	2.0
Locomotion velocity, session 3	5.8	6.8	8.5	2.7	2.9	-2.9	-1.6
Locomotion distance, session 3	0.0	0.1	0.2	0.0	0.0	-0.0	-0.5
Stereotopy head waving bouts, day 3	5.3	6.2	8.8	3.0	2.8	-2.8	-0.3
Stereotopy head waving duration, day 3	5.7	6.8	9.0	2.9	3.0	-3.0	-0.8
Locomotion velocity, session 7	0.7	0.7	1.0	1.0	0.8	-0.8	-0.7
Locomotion distance, session 7	0.4	0.5	1.1	-0.7	-0.5	0.5	-1.0
Stereotopy head waving bouts, day 7	0.5	0.6	1.2	0.9	0.4	-0.3	1.1
Stereotopy head waving duration, day 7	0.7	0.9	1.5	1.2	0.7	-0.6	1.1
Locomotion velocity, session 8	1.9	2.3	4.1	2.0	1.2	-1.1	1.6
Locomotion distance, session 8	0.6	0.8	1.6	1.3	0.8	-0.7	0.8
Degree of sensitization distance	0.3	0.3	0.4	-0.5	-0.6	0.6	0.3
Degree of sensitization stereotypy	1.5	1.6	2.0	-0.9	-1.4	1.4	1.4
Conditioned locomotion	1.7	2.0	3.1	-1.7	-1.5	1.5	-0.7
Cocaine response after cond. corrected	6.2	7.0	11.6	-3.4	-2.8	2.8	-0.8
Cocaine response after cond. not corrected	6.4	7.0	11.5	-3.4	-2.9	2.8	-0.9
Cocaine response before conditioning	0.6	0.7	1.2	1.1	0.9	-0.9	-0.1
Saline control response	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.0
Bone: connectivity density	0.6	1.0	3.6	0.3	-0.4	0.4	1.9
Bone: cortical apparent density	1.0	1.3	2.2	-1.5	-1.2	1.2	0.4
Bone: cortical area	0.6	0.8	1.7	-0.4	-0.9	0.9	1.3
Bone: cortical porosity	0.6	0.7	1.2	1.1	0.8	-0.7	0.5
Bone: cortical porosity	0.6	0.6	1.7	0.9	0.3	-0.2	1.3
Bone: cortical thickness	1.0	1.6	2.0	-1.0	-1.4	1.4	1.2
Bone: cortical thickness	0.5	0.5	1.4	-0.8	-0.3	0.2	-1.2
Bone: cortical tissue density	0.7	1.0	1.8	-1.3	-1.0	1.0	0.3
Condit. Reinf. active minus inactive responses	4.3	4.8	6.3	2.4	2.5	-2.5	-1.0
Condit. Reinf. active-inactive response ratio	1.8	2.0	2.4	1.0	1.5	-1.5	-1.5
Condit. Reinf. active responses	4.3	5.3	8.6	2.9	2.5	-2.5	0.2
Condit. Reinf. inactive responses	1.9	2.3	4.3	2.1	1.3	-1.2	1.3
Incentive salience index mean	2.9	3.6	5.9	2.4	2.1	-2.0	0.2
Condit. Reinf. lever presses	1.3	1.8	4.7	1.4	0.5	-0.4	2.2
Condit. Reinf. active minus inactive responses	1.6	1.9	3.3	0.8	1.3	-1.4	-1.8
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.7	-0.8	-0.2	0.1	-1.3
Condit. Reinf. active responses	1.4	1.9	2.2	1.0	1.5	-1.5	-1.4
Condit. Reinf. inactive responses	0.9	1.1	1.4	1.0	1.2	-1.2	-0.7
Condit. Reinf. lever presses	1.8	2.4	2.9	1.2	1.6	-1.6	-1.7
Condit. Reinf. lever reinforcers received	1.1	1.5	2.8	0.7	1.1	-1.2	-1.7
Conditioned reinforcement - actives	1.9	1.9	2.7	1.6	1.5	-1.5	-0.6
Conditioned reinforcement - inactives	0.4	0.5	0.6	-0.8	-0.7	0.7	-0.5
Conditioned locomotion	6.0	7.2	9.1	3.0	3.0	-3.0	-1.4
Patch foraging indifference point 0 sec	0.1	0.2	0.3	-0.3	-0.5	0.5	0.6
Patch foraging indifference point AUC	0.5	0.6	0.8	0.8	0.9	-0.9	-0.5
Delay disc. indifference point, 0s delay	6.3	6.9	10.6	-1.7	-2.6	2.7	3.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.6	-0.3	0.3	0.1
Delay disc. indifference point, 2s delay	4.7	5.2	6.6	-2.1	-2.5	2.6	1.9
Delay disc. indifference point, 24s delay	1.0	1.0	1.7	-1.3	-1.1	1.1	0.0
Delay disc. indifference point, 4s delay	0.7	0.8	0.9	-0.8	-0.9	1.0	0.8
Delay disc. indifference point, 8s delay	1.5	1.5	2.5	-1.6	-1.3	1.3	-0.1
Indifference point function ln k	0.3	0.4	0.6	-0.8	-0.7	0.6	-0.2
Indifference point function log k	0.3	0.4	0.6	-0.8	-0.7	0.6	-0.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.3	-0.4	0.4	0.4
Patch foraging total patch changes 12 sec	0.3	0.5	0.7	-0.8	-0.7	0.7	-0.3
Patch foraging total patch changes 18 sec	0.9	1.1	1.5	1.2	1.2	-1.2	-0.5
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	0.2	0.2	-0.2	0.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.2	0.5	0.5	-0.5	0.1
Patch foraging time to switch 0 sec	1.3	1.9	6.3	0.1	-0.8	0.9	2.5
Patch foraging water rate 0 sec	0.9	1.4	4.3	-1.1	-0.4	0.3	-2.1
Patch foraging water rate 12 sec	2.1	3.2	5.7	-2.4	-1.7	1.6	-1.4
Patch foraging water rate 18 sec	2.1	2.9	9.5	-1.4	-0.3	0.2	-3.1
Patch foraging water rate 24 sec	2.3	3.2	6.5	-2.0	-1.1	1.0	-2.6
Patch foraging water rate 6 sec	1.0	1.4	5.1	-0.7	0.1	-0.2	-2.3
Seeking ratio, delayed vs. immediate footshock	3.5	4.0	5.5	2.2	2.3	-2.3	-0.5
Distance traveled before self-admin	0.6	0.6	0.9	-0.6	-0.7	0.8	0.9
Distance traveled after self-admin	0.5	0.5	0.7	0.8	0.8	-0.8	0.1
Extensor digitorum longus weight	3.9	15.4	20.5	-4.5	-4.5	4.5	0.5
Bone: elastic displacement	0.1	0.1	0.1	0.2	0.3	-0.4	0.0
Bone: elastic work	0.3	0.4	0.5	-0.7	-0.7	0.7	0.5
Bone: endosteal estimation	0.1	0.2	0.3	-0.4	-0.5	0.5	0.6
Bone: endosteal perimeter	0.3	0.7	1.3	1.1	0.8	-0.8	0.3
Epididymis fat weight	0.3	0.6	0.8	0.7	0.9	-0.9	-0.8
Delta time in closed arm before/after self-admin	2.2	2.2	3.2	-1.8	-1.2	1.1	-1.7
Delta time in open arm before/after self-admin	1.0	1.0	1.1	-0.9	-1.0	1.1	1.0
Diff in mean of infusions in LGA sessions	1.8	2.0	2.6	1.5	1.6	-1.6	-0.7
Delay discount exponential model param	2.0	2.1	2.8	1.7	1.6	-1.6	-0.6
Extinction: sum of active levers before priming	1.1	1.1	1.6	0.8	1.0	-1.1	-1.3
Active lever presses in extinction session 6	1.9	1.9	2.6	1.5	1.6	-1.6	-0.3
Bone: final force	1.1	1.8	2.2	-1.1	-1.5	1.5	1.3
Bone: final moment	0.9	1.5	1.8	-1.0	-1.3	1.3	1.2
Food consumed during 24 hour testing period	0.8	0.9	1.9	-1.4	-1.0	0.9	-0.0
Glucose	1.5	2.3	3.4	-1.8	-1.7	1.7	0.4
Heart weight	0.3	0.4	1.3	-0.0	0.4	-0.4	-1.1
Delay discount hyperbolic model param	2.7	2.8	3.6	1.9	1.9	-1.9	-0.8
Intermittent access intake day 1-15 change	5.5	5.4	6.9	2.3	2.6	-2.6	-1.6
Intermittent access intake escalation	5.2	5.1	5.9	1.9	2.4	-2.4	-2.3
Intermittent access intake escalation 2	6.2	6.2	7.3	2.1	2.7	-2.7	-2.4
Intermitt. access day 1 inactive lever presses	0.3	0.3	1.2	-0.1	0.2	-0.2	-1.1
Intermitt. access day 15 inactive lever presses	0.5	0.5	0.6	0.6	0.7	-0.8	-0.8
Intermitt. access escalation Index	0.5	0.4	1.5	-0.0	-0.3	0.4	1.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.1	-0.2	0.2	0.1
Intermittent access day 15 total infusions	1.7	1.9	2.2	1.1	1.5	-1.5	-1.4
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.1	1.0	1.1	-1.1	-0.8
Intermittent access total infusions	0.2	0.2	0.4	0.3	0.5	-0.5	-0.6
Intermittent access day 1 locomotion	0.4	0.4	0.5	0.5	0.7	-0.7	-0.6
Intermittent access day 15 total locomotion	3.2	3.4	4.4	1.9	2.1	-2.1	-1.1
Intermittent access total locomotion	0.8	1.0	1.3	1.1	1.1	-1.1	-0.4
Intermittent access standard deviation	2.2	2.3	2.7	1.3	1.6	-1.6	-1.5
Left kidney weight	0.1	0.2	0.6	0.3	0.3	-0.2	0.8
Right kidney weight	1.0	2.9	4.1	1.8	2.0	-2.0	-0.6
Cocaine induced anxiety	0.9	1.0	1.5	1.2	0.9	-0.8	1.1
Post-drug Anxiety	0.9	1.0	1.6	1.3	0.9	-0.8	0.9
Baseline Anxiety	0.4	0.4	1.4	0.0	0.3	-0.4	-1.2
Tail length	2.6	8.0	10.0	2.8	3.2	-3.2	-2.0
Length with tail	1.6	5.7	7.6	2.7	2.7	-2.7	-0.7
Length without tail	0.3	0.7	1.4	1.0	0.5	-0.4	1.2
Times rat made contact with spout	0.5	0.6	1.3	-1.1	-0.6	0.6	-0.7
Lifetime Intake	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3
Liver weight, left	1.8	2.8	3.7	-1.9	-1.9	1.9	0.5
Liver weight, right	1.1	1.8	2.4	-1.2	-1.5	1.6	1.2
Locomotor activity	2.8	4.5	7.2	2.7	2.3	-2.3	0.4
Locomotor testing distance	1.5	2.6	3.8	2.0	1.8	-1.8	0.0
Locomotor testing rearing	0.1	0.2	0.7	-0.3	-0.0	0.0	-0.9
Locomotion in novel chamber	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.5
Locomotion in novel chamber post-restriction	0.8	1.0	1.2	0.8	1.0	-1.1	-1.1
Fecal boli incidents, locomotor time 1	1.5	1.6	2.1	-1.4	-1.4	1.4	0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.3	-0.3	0.2
Time >=10cm from walls, locomotor time 1	1.0	1.0	2.6	-0.5	-0.8	0.9	1.6
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.3	0.5	-0.5	-0.5
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.5	0.6	-0.6	-0.4
Rest time, locomotor task time 1	0.5	0.6	1.0	1.0	0.9	-0.8	0.1
Distance moved, locomotor task time 1	0.9	1.0	1.9	-0.6	-0.9	0.9	1.4
Vertical activity count, locomotor time 1	0.8	0.8	1.5	-1.2	-0.8	0.8	-0.6
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.7	-1.6	-1.5	1.5	0.2
Bouts of movement, locomotor time 2	0.8	0.9	1.3	1.1	0.9	-0.9	0.8
Total resting periods, locomotor time 2	0.8	0.9	1.3	1.1	0.9	-0.8	0.9
Rest time, locomotor task time 2	0.6	0.7	0.9	1.0	0.9	-0.9	0.4
Distance moved, locomotor task time 2	0.6	0.7	1.0	-0.9	-1.0	1.0	-0.0
Vertical activity count, locomotor time 2	1.0	1.0	1.4	-1.2	-1.1	1.0	-0.7
Light reinforcement 1	5.5	10.1	13.9	3.7	3.6	-3.6	-0.7
Light reinforcement 2	2.0	2.7	4.1	2.0	1.8	-1.8	-0.2
Bone: marrow area	0.1	0.2	0.3	-0.4	-0.5	0.5	0.6
Bone: maximum diameter	0.8	1.5	2.7	1.6	1.3	-1.2	0.6
Bone: maximum force	1.1	1.8	2.4	-1.2	-1.5	1.5	1.0
Bone: maximum moment	0.9	1.5	1.9	-1.2	-1.4	1.4	0.9
Mean time between licks in bursts	3.4	4.8	6.0	2.2	2.4	-2.4	-1.6
Mean num. licks in bursts	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3
Cd content in liver	0.3	0.3	0.4	-0.5	-0.6	0.6	0.5
Co content in liver	0.5	0.6	0.8	0.9	0.8	-0.8	-0.5
Cu content in liver	0.4	0.5	1.7	0.3	-0.2	0.3	1.3
Fe content in liver	0.2	0.2	0.3	0.6	0.3	-0.3	-0.6
K content in liver	0.8	0.8	2.0	1.1	0.3	-0.2	1.4
Mg content in liver	0.7	0.7	2.1	0.9	0.1	-0.1	1.4
Mn content in liver	2.6	2.9	5.5	2.3	1.4	-1.3	1.7
Na content in liver	1.0	1.1	3.1	0.4	-0.6	0.7	1.8
Rb content in liver	0.6	0.8	2.6	0.1	-0.5	0.5	1.6
Se content in liver	0.5	0.6	1.1	1.1	0.8	-0.7	0.1
Sr content in liver	0.4	0.3	1.1	-0.4	-0.1	0.0	-1.1
Zn content in liver	1.9	2.1	5.5	0.3	1.1	-1.2	-2.3
Bone: minimum diameter	0.1	0.1	0.4	0.4	0.1	-0.0	0.6
Time in familiar zone, hab. session 1	2.1	1.9	2.4	1.0	1.5	-1.5	-1.6
Time in novel zone, hab. session 1	1.2	1.2	2.3	-0.6	-1.0	1.0	1.5
Total zone transitions, hab. session 1	1.7	2.4	4.0	2.0	1.4	-1.4	1.3
Total locomotion distance, hab. session 1	2.7	3.8	6.6	2.6	1.6	-1.5	1.9
Locomotion velocity, hab. session 1	3.0	4.3	7.6	2.8	1.9	-1.8	1.6
Time in familiar zone, hab. session 2	5.3	5.4	6.8	1.6	2.6	-2.6	-2.4
Time in novel zone, hab. session 2	4.4	4.4	5.1	-1.8	-2.2	2.3	2.0
Total zone transitions, hab. session 2	1.6	2.1	7.7	0.8	0.1	0.0	2.8
Total locomotion distance, hab. session 2	1.9	2.5	3.4	1.9	1.5	-1.4	1.4
Locomotion velocity, hab. session 2	2.2	3.0	3.9	2.0	1.5	-1.4	1.9
Novel to familiar place preference ratio	4.0	4.1	5.6	-1.4	-2.1	2.1	2.4
Novelty place preference	2.5	2.6	4.2	-1.0	-1.6	1.6	2.1
Time in novel zone, NPP test	2.7	2.8	3.9	-1.2	-1.7	1.7	2.0
Total zone transitions, NPP test	0.8	1.1	3.6	0.9	0.3	-0.2	1.9
Total locomotion distance, NPP test	0.9	1.2	3.8	1.1	0.3	-0.2	1.9
Locomotion velocity, NPP test	1.0	1.4	3.4	1.2	0.5	-0.5	1.8
Intraocular pressure	0.8	1.2	3.3	-1.1	-0.3	0.2	-1.8
Delta distance traveled before/after self-admin	1.6	1.7	2.2	1.5	1.5	-1.5	-0.6
Delta ambulatory time before/after self-admin	1.8	2.0	2.7	1.7	1.6	-1.6	-0.4
Parametrial fat weight	0.3	0.6	0.8	0.5	0.8	-0.8	-0.9
Pavlov. Cond. lever latency	0.7	0.9	1.8	-1.2	-0.4	0.3	-1.4
Pavlov. Cond. magazine entry latency	3.5	4.5	5.9	2.4	2.4	-2.3	-1.1
Pavlov. Cond. change in total contacts	0.4	0.4	0.9	1.0	0.6	-0.5	0.2
Pavlov. Cond. index score	1.2	1.5	3.2	1.8	1.2	-1.1	0.5
Pavlov. Cond. latency score	1.5	1.9	3.9	2.0	1.2	-1.1	0.9
Pavlov. Cond. lever contacts	1.0	1.2	2.2	1.4	0.6	-0.5	1.5
Pavlov. Cond. magazine entry number	1.2	1.5	2.4	-1.6	-1.3	1.3	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.2	-0.3	0.1	-0.2	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	3.8	1.9	1.5	-1.4	0.3
Pavlov. Cond. response bias	1.7	2.0	3.3	1.8	1.6	-1.5	-0.4
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.7	-0.7	0.8	0.7
Pavlov. Cond. magazine entry latency	0.4	0.4	0.5	0.7	0.7	-0.7	-0.4
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	0.4	0.7	-0.7	-0.9
Pavlov. Cond. index score	0.5	0.7	0.8	0.7	0.8	-0.8	-0.9
Pavlov. Cond. latency score	0.4	0.5	0.6	0.7	0.8	-0.8	-0.6
Pavlov. Cond. lever contacts	0.5	0.7	1.3	0.5	0.7	-0.8	-1.1
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-1.0	-0.9	0.9	0.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	-1.0	-0.7	0.7	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.8	0.8	0.9	-0.9	-0.7
Pavlov. Cond. response bias	1.2	1.6	2.3	0.9	1.3	-1.3	-1.5
Time in closed arm before self-admin	1.0	1.1	3.6	-0.0	-0.6	0.7	1.9
Time in closed arm after self-admin	0.0	0.0	0.1	0.0	0.1	-0.1	-0.3
Time in open arm before self-admin	0.5	0.6	0.7	0.6	0.8	-0.8	-0.8
Time in open arm after self-admin	0.7	0.8	1.1	-1.1	-1.0	1.0	0.3
Bone: periosteal estimation	0.3	0.6	1.6	-0.2	-0.6	0.7	1.3
Bone: periosteal perimeter	0.2	0.4	0.7	0.8	0.4	-0.3	0.9
Bone: post-yield work	0.3	0.4	0.7	-0.7	-0.8	0.8	-0.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	-0.2	0.2	-0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.6	-0.3	0.3	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.1	0.2	-0.2	-0.1
Progressive ratio test 2 active lever presses	0.3	0.3	1.0	-0.0	0.3	-0.3	-1.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.3	0.4	-0.4	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.4	0.3	-0.2	0.1
Incentive Sensitization - Responses	0.2	0.2	0.7	-0.1	0.2	-0.2	-0.9
Incentive Sensitization - Breakpoint	0.2	0.2	0.7	0.0	0.3	-0.3	-0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.0	-0.0	0.2
Progressive ratio	0.0	0.1	0.1	-0.2	-0.3	0.3	0.0
Food seeking constrained by brief footshock	0.6	0.7	1.2	1.1	0.9	-0.8	0.4
Seeking ratio, punishment vs. effort	0.3	0.4	0.6	0.8	0.7	-0.6	0.4
Retroperitoneal fat weight	0.2	0.6	0.8	-0.9	-0.8	0.8	0.1
Reaction time number correct	1.3	1.8	3.0	-1.7	-1.1	1.0	-1.4
Reaction time mean minus median	0.5	0.6	0.8	0.6	0.8	-0.8	-0.9
Reaction time mean minus median AUC	0.1	0.2	0.6	0.4	0.1	-0.0	0.8
Reaction time num false alarms	0.5	0.7	1.6	-0.7	-0.6	0.5	-1.3
Reaction time num false alarms AUC	0.7	0.9	2.1	-0.9	-0.7	0.6	-1.4
Reaction time trials correct on left	1.3	1.8	3.0	-1.7	-1.1	1.0	-1.4
Reaction time trials on left	1.2	1.7	3.0	-1.7	-1.1	1.0	-1.3
Reaction time mean	0.1	0.1	0.2	-0.2	-0.2	0.2	0.5
Reaction time mean AUC	0.1	0.1	0.3	-0.2	-0.3	0.3	0.5
Median of all reaction times	0.3	0.5	0.8	-0.5	-0.7	0.7	0.9
Reaction time omissions	0.1	0.2	0.2	0.3	0.5	-0.5	0.2
Reaction time false alarm rate	0.0	0.0	0.1	0.1	-0.2	0.2	-0.2
Reaction time premature initiation rate	0.8	1.0	1.7	0.5	1.0	-1.1	-1.3
Reaction time premature initiations	1.0	1.4	4.6	-0.4	0.5	-0.6	-2.1
Std. dev. reaction times	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Reaction time trials completed	1.2	1.7	3.0	-1.7	-1.1	1.0	-1.3
Reaction time trials AUC	1.4	2.0	3.3	-1.8	-1.1	1.0	-1.6
Run reversals in cocaine runway, females	0.4	0.4	0.5	0.7	0.7	-0.7	-0.0
Run reversals in cocaine runway, males	1.5	1.4	1.9	1.4	1.4	-1.4	-0.2
Latency to leave start box in cocaine runway	0.8	0.9	1.4	1.2	0.8	-0.7	0.9
Latency to leave start box in cocaine runway, F	1.0	1.1	4.2	0.4	-0.2	0.3	2.1
Latency to leave start box in cocaine runway, M	2.4	2.3	3.3	1.1	1.5	-1.6	-1.8
Std. dev. time between licks in bursts	0.5	0.7	1.0	1.0	0.9	-0.9	-0.0
Total sessions with >9 infusions	0.1	0.1	0.2	-0.0	-0.1	0.1	0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.4	0.4	-0.4	-0.0
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3
Short access day 1 total infusions	0.4	0.4	0.8	0.9	0.6	-0.5	0.6
Short access day 10 total infusions	0.1	0.2	0.6	-0.1	0.2	-0.2	-0.8
Short access total infusions	0.0	0.0	0.0	0.1	0.0	-0.0	0.1
Short access day 1 locomotion	0.9	1.0	1.4	1.2	1.1	-1.1	0.0
Short access day 10 total locomotion	3.0	3.4	4.2	1.8	2.0	-2.0	-1.5
Short access total locomotion	0.7	0.7	1.0	1.0	1.0	-0.9	-0.3
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.3	-0.4	0.4	-0.1
Compulsive drug intake	1.2	1.3	1.6	-0.8	-1.2	1.2	1.3
One hour access (shock baseline)	0.3	0.4	1.3	-0.0	0.3	-0.3	-1.1
Social response proportion	0.8	0.9	1.3	1.2	1.0	-1.0	0.6
Social responses	5.8	7.5	10.6	3.3	3.1	-3.1	-0.5
Social time	0.5	0.7	0.7	-0.7	-0.8	0.9	0.9
Soleus weight	7.7	22.5	29.6	-5.2	-5.4	5.4	1.9
Bone: stiffness	2.1	3.3	4.7	-1.6	-2.1	2.2	1.3
Tibialis anterior weight	0.9	2.9	4.1	-1.8	-2.0	2.0	0.7
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.1	1.0	0.8	-0.8	0.8
Time to tail flick, vehicle, after self-admin	0.5	0.6	2.0	-0.0	0.3	-0.3	-1.4
Time to tail flick, test, before self-admin	0.5	0.4	0.7	0.8	0.5	-0.5	0.8
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.8	0.7	-0.7	0.2
Delta time to tail flick, vehicle, before/after SA	1.0	0.9	1.9	-1.0	-0.7	0.6	-1.4
Delta time to tail flick, test, before/after SA	0.4	0.4	1.1	0.2	0.4	-0.4	-1.1
Tibia length	0.7	1.9	2.5	1.3	1.6	-1.6	-0.9
Ambulatory time before self-admin	0.5	0.5	0.6	-0.6	-0.7	0.7	0.8
Ambulatory time after self-admin	0.3	0.3	0.4	0.6	0.6	-0.6	0.2
Bone: tissue strength	1.6	1.5	1.9	-1.1	-1.4	1.4	1.1
Total heroin consumption	1.7	2.0	2.6	1.5	1.6	-1.6	-0.6
Bone: trabecular number	1.0	1.6	2.9	1.7	1.2	-1.1	1.0
Bone: trabecular spacing	1.9	2.4	4.2	-1.9	-1.0	0.9	-2.0
Bone: trabecular thickness	2.3	2.8	9.7	1.2	0.1	0.0	3.1
Bone: trabecular tissue density	1.3	1.8	2.4	-1.6	-1.5	1.5	0.3
Water consumed over 24 hours	0.6	0.8	1.2	-0.7	-0.8	0.9	1.1
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3