Hub : Genes

Tmem208

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Tmem208	0.07	0.06	4.6e-04	0.03	0.04	0.03	0.03	4.1e-03	6.5e-04	1.8e-03	1.3e-03
2	NAcc	gene expression	Tmem208	0.06	0.08	2.1e-03	0.02	0.01	0.01	0.02	7.0e-04	2.5e-03	2.0e-02	1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.1	0.1	-0.3	0.2
Area under the delay curve	0.0	0.0	0.0	-0.1	-0.1
BMI with tail	0.0	0.1	0.1	-0.3	0.2
BMI without tail	0.0	0.0	0.0	0.1	0.2
Body weight	0.4	1.6	1.9	-1.2	1.4
Weight adjusted by age	0.0	0.0	0.0	-0.0	0.1
Bone surface	1.3	2.4	2.8	-1.7	1.4
Bone volume	1.1	1.9	2.1	-1.4	1.3
Breakpoint value in progressive ratio session	2.4	2.8	3.1	1.6	-1.8
Number of licking bursts	0.6	0.9	1.1	-1.0	0.9
Context. condit. distance diff. score	0.1	0.1	0.2	-0.0	-0.4
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	0.2
Locomotion distance, session 1	0.1	0.1	0.1	0.4	-0.1
Locomotion velocity, session 2	0.5	0.6	0.9	0.9	-0.6
Locomotion distance, session 2	0.1	0.1	0.1	0.4	-0.2
Locomotion velocity, session 3	0.3	0.4	0.4	0.5	-0.6
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.2	0.4
Stereotopy head waving duration, day 3	0.4	0.5	0.7	-0.6	0.8
Locomotion velocity, session 7	0.0	0.0	0.0	0.0	-0.2
Locomotion distance, session 7	0.1	0.1	0.1	0.1	-0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.4	0.1
Stereotopy head waving duration, day 7	0.3	0.4	0.6	-0.8	0.5
Locomotion velocity, session 8	0.1	0.1	0.1	0.2	-0.3
Locomotion distance, session 8	0.3	0.5	0.7	0.5	-0.9
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.0
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.6	0.3
Conditioned locomotion	2.2	2.5	2.7	-1.7	1.5
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.6	0.5
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.1	-0.0
Cocaine response before conditioning	1.2	1.4	1.4	1.2	-1.2
Saline control response	4.7	6.3	6.7	-2.4	2.6
Bone: connectivity density	0.1	0.1	0.1	0.2	-0.4
Bone: cortical apparent density	1.1	1.5	1.8	1.1	-1.3
Bone: cortical area	0.3	0.5	0.5	-0.7	0.6
Bone: cortical porosity	0.1	0.2	0.2	0.4	-0.4
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.4
Bone: cortical thickness	0.1	0.1	0.1	-0.3	0.3
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1
Bone: cortical tissue density	1.1	1.5	1.9	1.1	-1.4
Condit. Reinf. active minus inactive responses	4.2	4.7	5.1	2.1	-2.3
Condit. Reinf. active-inactive response ratio	3.8	4.0	4.8	1.8	-2.2
Condit. Reinf. active responses	2.8	3.5	3.7	1.8	-1.9
Condit. Reinf. inactive responses	0.2	0.2	0.2	0.4	-0.4
Incentive salience index mean	2.1	2.6	2.8	1.5	-1.7
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	-0.4
Condit. Reinf. active minus inactive responses	0.8	1.1	1.2	-1.1	0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.7	-0.8	0.8
Condit. Reinf. active responses	0.5	0.6	0.7	-0.8	0.8
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	-0.3
Condit. Reinf. lever presses	2.3	3.2	3.3	1.8	-1.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.3	0.3
Conditioned reinforcement - actives	0.5	0.9	1.1	1.0	-0.8
Conditioned reinforcement - inactives	0.2	0.3	0.4	-0.6	-0.4
Conditioned locomotion	0.6	0.8	1.4	-1.2	0.5
Patch foraging indifference point 0 sec	3.1	5.7	6.1	-2.5	2.3
Patch foraging indifference point AUC	1.8	2.6	2.7	-1.7	1.6
Delay disc. indifference point, 0s delay	0.7	0.8	0.9	0.9	-0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	0.6
Delay disc. indifference point, 2s delay	0.2	0.3	0.5	-0.7	-0.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.1	0.1
Delay disc. indifference point, 4s delay	0.4	0.4	0.6	0.5	-0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.0	-0.0
Indifference point function ln k	0.3	0.5	0.8	0.5	-0.9
Indifference point function log k	0.3	0.5	0.8	0.5	-0.9
Patch foraging total patch changes 0 sec	3.0	5.7	5.9	-2.4	2.3
Patch foraging total patch changes 12 sec	3.0	3.8	4.1	-2.0	1.9
Patch foraging total patch changes 18 sec	2.7	4.1	4.6	-2.1	1.9
Patch foraging total patch changes 24 sec	0.2	0.3	0.5	-0.7	0.4
Patch foraging total patch changes 6 sec	2.0	3.1	3.3	-1.8	1.7
Patch foraging time to switch 0 sec	0.8	1.6	1.9	1.4	-1.2
Patch foraging water rate 0 sec	1.4	3.0	3.3	-1.6	1.8
Patch foraging water rate 12 sec	0.1	0.2	0.3	-0.6	0.3
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.6	0.1
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.1	0.2
Patch foraging water rate 6 sec	0.6	0.9	1.3	-1.1	0.7
Seeking ratio, delayed vs. immediate footshock	2.5	3.0	3.7	-1.9	1.5
Distance traveled before self-admin	0.7	0.9	1.8	-1.3	-0.3
Distance traveled after self-admin	0.1	0.1	0.2	-0.4	0.0
Extensor digitorum longus weight	0.7	2.6	2.7	1.7	-1.5
Bone: elastic displacement	1.7	2.0	2.1	-1.3	1.4
Bone: elastic work	0.6	0.8	0.9	-0.8	0.9
Bone: endosteal estimation	0.1	0.2	0.2	-0.5	0.5
Bone: endosteal perimeter	0.2	0.5	0.7	-0.8	0.6
Epididymis fat weight	2.1	7.2	9.0	-3.0	2.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.2	0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.6	-0.0	-0.8
Diff in mean of infusions in LGA sessions	0.6	0.7	0.8	0.8	-0.9
Delay discount exponential model param	0.0	0.0	0.0	-0.0	0.2
Extinction: sum of active levers before priming	0.7	0.8	1.1	1.0	-0.7
Active lever presses in extinction session 6	0.1	0.1	0.1	0.0	0.3
Bone: final force	0.9	1.4	1.4	1.2	-1.1
Bone: final moment	0.4	0.6	0.6	0.8	-0.7
Food consumed during 24 hour testing period	0.4	0.6	0.6	-0.8	0.7
Glucose	1.8	2.8	2.8	1.7	-1.7
Heart weight	0.0	0.0	0.1	0.1	-0.3
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.1	0.3
Intermittent access intake day 1-15 change	1.0	2.1	2.6	1.6	-1.3
Intermittent access intake escalation	1.2	2.4	2.8	1.7	-1.4
Intermittent access intake escalation 2	0.8	0.9	1.2	1.1	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.6	0.1	-0.8
Intermitt. access escalation Index	0.3	0.4	0.6	-0.5	0.8
Intermittent access day 1 total infusions	0.0	0.1	0.1	0.3	0.2
Intermittent access day 15 total infusions	1.4	2.1	2.8	1.7	-1.1
Intermittent access terminal intake (last 3 days)	2.4	3.2	3.9	2.0	-1.6
Intermittent access total infusions	1.8	2.1	2.9	1.7	-1.1
Intermittent access day 1 locomotion	1.3	1.7	2.0	-1.2	1.4
Intermittent access day 15 total locomotion	0.2	0.3	0.4	-0.6	0.5
Intermittent access total locomotion	0.0	0.0	0.0	-0.2	0.1
Intermittent access standard deviation	0.1	0.3	0.3	-0.6	0.5
Left kidney weight	1.5	7.1	8.1	2.4	-2.8
Right kidney weight	1.5	6.9	7.7	2.5	-2.8
Cocaine induced anxiety	2.6	3.6	4.0	-1.8	2.0
Post-drug Anxiety	0.5	0.6	0.6	-0.7	0.8
Baseline Anxiety	1.4	1.6	1.7	1.2	-1.3
Tail length	0.0	0.2	0.3	-0.0	0.6
Length with tail	0.2	0.9	1.1	-0.8	1.0
Length without tail	0.6	1.8	1.8	-1.3	1.3
Times rat made contact with spout	1.8	2.1	2.5	-1.3	1.6
Lifetime Intake	1.5	1.8	2.5	1.6	-1.0
Liver weight, left	0.2	0.3	0.4	-0.6	0.6
Liver weight, right	0.6	1.0	1.3	-0.8	1.1
Locomotor activity	2.6	4.0	4.4	-2.1	1.9
Locomotor testing distance	2.1	3.8	3.9	-1.9	2.0
Locomotor testing rearing	0.2	0.3	0.5	-0.7	0.4
Locomotion in novel chamber	2.2	2.8	3.4	-1.8	1.5
Locomotion in novel chamber post-restriction	1.9	3.1	4.0	-1.5	2.0
Fecal boli incidents, locomotor time 1	1.6	2.3	3.9	-0.8	2.0
Change in fecal boli incidents, locomotor task	0.7	0.7	1.0	0.6	-1.0
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.4	-0.4	1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.0	0.5
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.3	0.3
Rest time, locomotor task time 1	0.2	0.2	0.4	0.7	-0.1
Distance moved, locomotor task time 1	0.1	0.2	0.4	-0.6	0.2
Vertical activity count, locomotor time 1	0.6	1.5	1.5	-1.2	1.2
Time >=10cm from walls, locomotor time 2	0.3	0.5	0.8	0.9	-0.4
Bouts of movement, locomotor time 2	0.6	0.9	1.0	1.0	-0.9
Total resting periods, locomotor time 2	0.7	1.2	1.4	1.2	-1.1
Rest time, locomotor task time 2	0.5	0.7	1.2	1.1	-0.4
Distance moved, locomotor task time 2	0.6	0.7	1.2	-1.1	0.4
Vertical activity count, locomotor time 2	1.0	1.4	1.8	-1.4	0.9
Light reinforcement 1	2.2	5.4	6.6	-2.6	2.1
Light reinforcement 2	2.4	3.7	4.3	-2.1	1.8
Bone: marrow area	0.1	0.2	0.2	-0.4	0.4
Bone: maximum diameter	0.5	0.9	1.0	-1.0	0.9
Bone: maximum force	0.3	0.4	0.4	0.7	-0.7
Bone: maximum moment	0.0	0.1	0.1	0.3	-0.3
Mean time between licks in bursts	0.0	0.1	0.1	-0.4	0.0
Mean num. licks in bursts	0.0	0.0	0.0	0.1	0.2
Cd content in liver	0.1	0.2	0.3	0.2	-0.5
Co content in liver	0.0	0.0	0.1	0.2	-0.1
Cu content in liver	0.8	0.9	1.0	1.0	-0.9
Fe content in liver	2.1	2.5	3.3	-1.3	1.8
K content in liver	0.1	0.1	0.1	0.3	-0.3
Mg content in liver	0.5	0.5	0.6	-0.6	0.8
Mn content in liver	0.6	0.7	0.8	-0.9	0.7
Na content in liver	0.0	0.0	0.0	0.1	0.0
Rb content in liver	0.2	0.2	0.3	0.5	-0.4
Se content in liver	0.0	0.0	0.0	0.2	-0.2
Sr content in liver	1.2	1.0	1.2	-1.1	0.9
Zn content in liver	1.6	1.8	1.8	1.3	-1.3
Bone: minimum diameter	0.1	0.2	0.3	-0.5	0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.4	-0.6	0.2
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.6	-0.2
Total zone transitions, hab. session 1	0.9	1.2	1.2	-1.1	1.1
Total locomotion distance, hab. session 1	1.2	1.7	1.7	-1.3	1.3
Locomotion velocity, hab. session 1	1.5	2.1	2.3	-1.4	1.5
Time in familiar zone, hab. session 2	0.7	0.8	1.0	-1.0	0.7
Time in novel zone, hab. session 2	4.6	4.7	5.6	2.4	-1.9
Total zone transitions, hab. session 2	2.3	3.0	3.4	-1.6	1.8
Total locomotion distance, hab. session 2	1.4	1.8	2.1	-1.3	1.4
Locomotion velocity, hab. session 2	1.3	1.8	2.0	-1.3	1.4
Novel to familiar place preference ratio	2.5	2.7	3.2	1.5	-1.8
Novelty place preference	3.9	4.2	4.7	1.9	-2.2
Time in novel zone, NPP test	3.6	3.8	4.3	1.8	-2.1
Total zone transitions, NPP test	1.9	2.8	3.0	-1.6	1.7
Total locomotion distance, NPP test	1.1	1.5	1.9	-1.1	1.4
Locomotion velocity, NPP test	1.0	1.4	1.7	-1.0	1.3
Intraocular pressure	0.6	0.8	1.1	0.7	-1.1
Delta distance traveled before/after self-admin	0.4	0.4	0.5	0.7	-0.6
Delta ambulatory time before/after self-admin	0.6	0.8	1.1	1.1	-0.7
Parametrial fat weight	7.0	16.5	17.0	-4.0	4.1
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.8	-0.6
Pavlov. Cond. change in total contacts	0.9	0.9	1.0	0.9	-1.0
Pavlov. Cond. index score	0.3	0.3	0.4	0.6	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.3	0.5	-0.4
Pavlov. Cond. lever contacts	0.5	0.6	0.7	0.8	-0.7
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.9	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.7	-0.5
Pavlov. Cond. response bias	0.2	0.2	0.4	0.6	-0.4
Pavlov. Cond. lever latency	1.3	1.7	1.8	-1.3	1.3
Pavlov. Cond. magazine entry latency	3.4	4.1	4.1	2.0	-2.0
Pavlov. Cond. change in total contacts	1.8	2.8	3.1	1.6	-1.8
Pavlov. Cond. index score	3.3	4.5	4.6	2.1	-2.1
Pavlov. Cond. latency score	3.4	4.5	4.5	2.1	-2.1
Pavlov. Cond. lever contacts	1.5	2.1	2.3	1.5	-1.4
Pavlov. Cond. magazine entry number	5.5	6.8	6.9	-2.6	2.6
Pavlov. Cond. intertrial magazine entries	4.6	7.0	7.2	-2.6	2.7
Pavlov. Cond. lever-magazine prob. diff.	3.8	5.0	5.1	2.3	-2.2
Pavlov. Cond. response bias	3.0	4.0	4.1	2.0	-2.0
Time in closed arm before self-admin	3.0	3.9	3.9	-2.0	2.0
Time in closed arm after self-admin	2.9	3.1	3.5	-1.9	1.6
Time in open arm before self-admin	1.5	1.6	1.7	1.3	-1.3
Time in open arm after self-admin	0.8	0.8	1.2	0.7	-1.1
Bone: periosteal estimation	0.3	0.6	0.7	-0.8	0.7
Bone: periosteal perimeter	0.8	1.3	1.5	-1.2	1.1
Bone: post-yield work	0.5	0.7	0.9	-0.9	0.7
Progressive ratio test 1 active lever presses	2.5	3.1	3.8	1.9	-1.5
Progressive ratio test 1 breakpoint	2.2	2.7	3.3	1.8	-1.4
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.3	-0.1
Progressive ratio test 2 active lever presses	1.7	1.9	3.0	1.7	-0.9
Progressive ratio test 2 breakpoint	1.8	2.1	3.1	1.8	-1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.4	-0.3
Incentive Sensitization - Responses	0.5	0.6	1.2	1.1	-0.2
Incentive Sensitization - Breakpoint	0.6	0.8	1.5	1.2	-0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	0.5	-0.9
Progressive ratio	0.2	0.3	0.5	-0.2	-0.7
Food seeking constrained by brief footshock	1.5	1.9	2.0	1.3	-1.4
Seeking ratio, punishment vs. effort	0.4	0.6	0.9	1.0	-0.5
Retroperitoneal fat weight	6.7	28.4	30.4	-5.5	5.1
Reaction time number correct	0.9	1.7	2.2	1.5	-1.1
Reaction time mean minus median	0.7	1.8	2.4	1.1	-1.6
Reaction time mean minus median AUC	0.6	1.4	1.9	1.0	-1.4
Reaction time num false alarms	0.1	0.1	0.2	0.3	-0.5
Reaction time num false alarms AUC	0.0	0.0	0.0	-0.1	0.1
Reaction time trials correct on left	0.9	1.7	2.2	1.5	-1.1
Reaction time trials on left	1.0	1.8	2.3	1.5	-1.1
Reaction time mean	0.3	0.5	1.0	-0.0	-1.0
Reaction time mean AUC	0.5	0.7	1.4	0.3	-1.2
Median of all reaction times	0.2	0.3	0.4	-0.4	-0.6
Reaction time omissions	0.2	0.3	0.5	-0.3	0.7
Reaction time false alarm rate	0.4	0.5	0.7	-0.8	0.6
Reaction time premature initiation rate	1.4	1.9	2.0	1.4	-1.4
Reaction time premature initiations	2.4	4.3	4.7	2.2	-2.0
Std. dev. reaction times	0.3	0.6	0.9	0.5	-1.0
Reaction time trials completed	1.0	1.8	2.3	1.5	-1.1
Reaction time trials AUC	1.0	1.9	2.4	1.5	-1.2
Run reversals in cocaine runway, females	1.7	1.7	1.8	-1.3	1.3
Run reversals in cocaine runway, males	0.9	0.9	1.4	-0.5	1.2
Latency to leave start box in cocaine runway	0.3	0.4	0.5	0.5	-0.7
Latency to leave start box in cocaine runway, F	1.3	1.4	1.9	1.4	-1.0
Latency to leave start box in cocaine runway, M	0.8	0.7	1.4	-1.2	0.3
Std. dev. time between licks in bursts	2.2	2.9	3.2	-1.8	1.6
Total sessions with >9 infusions	1.1	1.3	1.9	1.4	-0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.1	0.1
Short access day 10 total inactive lever presses	0.1	0.3	0.3	-0.5	0.5
Short access day 1 total infusions	0.2	0.3	0.5	0.7	0.0
Short access day 10 total infusions	0.2	0.2	0.4	0.7	-0.1
Short access total infusions	1.4	1.7	2.6	1.6	-0.9
Short access day 1 locomotion	0.2	0.2	0.4	0.6	0.1
Short access day 10 total locomotion	1.3	2.5	3.0	-1.7	1.4
Short access total locomotion	0.2	0.3	0.3	-0.6	0.5
One hour access (0.3 mA shock)	0.7	0.9	1.5	1.2	-0.4
Compulsive drug intake	0.1	0.1	0.2	-0.4	0.4
One hour access (shock baseline)	0.7	1.0	1.8	1.3	-0.5
Social response proportion	0.3	0.3	0.5	0.7	-0.4
Social responses	0.0	0.0	0.1	-0.0	0.3
Social time	0.0	0.0	0.0	-0.0	0.1
Soleus weight	0.2	0.6	0.7	-0.8	0.7
Bone: stiffness	3.1	5.1	5.5	2.2	-2.3
Tibialis anterior weight	0.1	0.5	0.6	0.8	-0.6
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.7	0.9	-0.2
Time to tail flick, vehicle, after self-admin	1.1	1.5	2.1	-0.9	1.4
Time to tail flick, test, before self-admin	4.1	4.3	5.4	-1.8	2.3
Time to tail flick, test, after self-admin	0.4	0.4	0.7	-0.3	0.8
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	2.0	-0.9	1.4
Delta time to tail flick, test, before/after SA	1.0	1.0	1.1	1.0	-1.0
Tibia length	0.0	0.0	0.1	0.3	0.0
Ambulatory time before self-admin	0.9	1.4	2.6	-1.6	0.4
Ambulatory time after self-admin	0.3	0.3	0.6	-0.8	0.2
Bone: tissue strength	0.3	0.3	0.4	0.5	-0.6
Total heroin consumption	1.2	1.5	1.5	1.2	-1.2
Bone: trabecular number	0.2	0.4	0.5	-0.7	0.5
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	0.4
Bone: trabecular thickness	0.5	0.7	0.8	0.9	-0.8
Bone: trabecular tissue density	0.7	1.1	1.2	1.1	-1.0
Water consumed over 24 hours	0.4	0.5	0.6	-0.7	0.7
Number of responses in last shaping day	1.1	1.2	2.1	0.6	-1.4