Hub : Genes

Tmem199

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Tmem199	0.02	0.02	6.1e-03	0.01	0.01	0.01	0.01	1.8e-02	1.0e-02	2.3e-02	2.1e-02
2	Adipose	gene expression	Tmem199	0.11	0.08	1.3e-10	0.08	0.08	0.07	0.08	4.2e-09	2.8e-09	2.4e-08	5.2e-09
3	IC	intron excision ratio	chr10_63903031_63903609	0.09	0.09	2.4e-03	0.04	0.05	0.04	0.05	9.5e-03	4.8e-03	7.5e-03	3.6e-03
4	IC	intron excision ratio	chr10_63902120_63902942	0.09	0.09	1.8e-03	0.04	0.05	0.04	0.05	8.3e-03	4.5e-03	5.8e-03	3.2e-03
5	pVTA	gene expression	Tmem199	0.4	0.24	5.6e-03	0.01	0.02	0.01	0.01	8.3e-02	1.4e-02	3.8e-02	4.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.9	3.2	3.9	-1.9	-1.9	-2.0	2.0	-0.9
Area under the delay curve	1.6	1.9	3.0	1.2	1.0	1.7	-1.7	-1.0
BMI with tail	1.7	5.8	6.8	-2.6	-2.6	-2.4	2.4	-1.9
BMI without tail	1.7	5.3	6.9	-2.5	-2.4	-2.6	2.6	-1.0
Body weight	2.5	11.0	12.5	-3.5	-3.5	-3.4	3.4	-2.7
Weight adjusted by age	0.1	0.2	0.5	-0.3	-0.1	-0.5	0.5	0.7
Bone surface	1.4	2.6	3.1	-1.7	-1.7	-1.8	1.8	-0.8
Bone volume	1.3	2.2	2.6	-1.6	-1.6	-1.6	1.6	-0.9
Breakpoint value in progressive ratio session	0.6	0.7	1.0	-0.6	-0.4	-1.0	1.0	0.8
Number of licking bursts	0.2	0.4	0.5	0.7	0.7	0.6	-0.6	0.6
Context. condit. distance diff. score	0.5	0.6	0.7	-0.8	-0.8	-0.8	0.8	-0.5
Locomotion velocity, session 1	2.1	2.2	2.6	-1.6	-1.6	-1.5	1.5	-1.2
Locomotion distance, session 1	0.2	0.3	0.3	-0.6	-0.6	-0.5	0.5	-0.5
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.2	0.2
Locomotion distance, session 2	1.1	1.5	1.7	-1.3	-1.3	-1.3	1.3	-0.8
Locomotion velocity, session 3	3.1	3.5	4.0	2.0	2.0	1.9	-1.9	1.6
Locomotion distance, session 3	0.3	0.4	0.5	0.6	0.6	0.7	-0.7	0.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.2	-0.1	-0.0	-0.2	0.2	0.4
Stereotopy head waving duration, day 3	0.9	1.0	2.9	0.9	1.0	0.5	-0.5	1.7
Locomotion velocity, session 7	0.3	0.3	0.5	-0.4	-0.3	-0.7	0.7	0.7
Locomotion distance, session 7	0.4	0.4	0.7	-0.7	-0.6	-0.8	0.8	0.2
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	-0.8	-0.7	-0.8	0.8	-0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.4	-0.4	-0.6	0.6	0.3
Locomotion velocity, session 8	0.1	0.1	0.3	-0.2	-0.3	-0.1	0.1	-0.5
Locomotion distance, session 8	0.7	1.0	1.2	-1.1	-1.1	-1.1	1.1	-0.6
Degree of sensitization distance	2.6	2.7	3.6	-1.8	-1.7	-1.9	1.9	-0.6
Degree of sensitization stereotypy	0.5	0.5	0.7	-0.8	-0.7	-0.8	0.8	-0.2
Conditioned locomotion	1.7	2.0	2.2	1.4	1.5	1.3	-1.3	1.5
Cocaine response after cond. corrected	1.5	1.8	2.1	-1.4	-1.4	-1.4	1.4	-1.1
Cocaine response after cond. not corrected	2.0	2.3	2.7	-1.7	-1.6	-1.5	1.5	-1.3
Cocaine response before conditioning	0.1	0.2	0.2	-0.5	-0.4	-0.4	0.4	-0.1
Saline control response	0.1	0.1	0.3	0.1	0.1	-0.0	0.0	0.6
Bone: connectivity density	3.3	5.1	6.5	-2.5	-2.4	-2.5	2.5	-0.9
Bone: cortical apparent density	0.5	0.7	0.9	0.9	0.9	0.7	-0.7	1.0
Bone: cortical area	1.1	1.7	2.3	1.4	1.3	1.5	-1.5	0.3
Bone: cortical porosity	0.2	0.2	0.3	-0.5	-0.4	-0.6	0.6	0.2
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.2
Bone: cortical thickness	2.4	4.0	4.9	2.2	2.2	2.1	-2.1	1.3
Bone: cortical thickness	0.1	0.1	0.4	0.2	0.3	0.1	-0.1	0.7
Bone: cortical tissue density	0.3	0.4	0.7	0.7	0.7	0.5	-0.5	0.9
Condit. Reinf. active minus inactive responses	0.7	0.8	0.9	0.9	1.0	0.8	-0.8	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.4	0.4	0.4	-0.4	0.3
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.2
Condit. Reinf. inactive responses	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.3
Incentive salience index mean	0.2	0.3	0.3	0.6	0.6	0.6	-0.6	0.4
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.4	-0.4	-0.3	0.3	-0.3
Condit. Reinf. active minus inactive responses	0.8	1.0	3.0	0.8	1.0	0.4	-0.4	1.7
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.2	0.9	0.9	0.6	-0.6	1.1
Condit. Reinf. active responses	0.6	0.8	2.6	0.7	0.8	0.3	-0.3	1.6
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.0	-0.2	0.2	0.6
Condit. Reinf. lever presses	2.3	3.1	3.7	1.9	1.9	1.7	-1.7	1.6
Condit. Reinf. lever reinforcers received	0.7	0.9	2.2	0.9	1.0	0.6	-0.6	1.5
Conditioned reinforcement - actives	0.2	0.4	0.5	-0.7	-0.7	-0.6	0.6	-0.5
Conditioned reinforcement - inactives	0.3	0.4	1.1	-0.5	-0.6	-0.3	0.3	-1.0
Conditioned locomotion	0.7	0.9	2.4	-0.8	-0.9	-0.5	0.5	-1.5
Patch foraging indifference point 0 sec	0.4	0.7	1.0	0.9	0.9	0.7	-0.7	1.0
Patch foraging indifference point AUC	1.8	2.6	3.1	1.8	1.7	1.7	-1.7	1.3
Delay disc. indifference point, 0s delay	0.7	0.8	1.2	0.9	0.8	1.1	-1.1	-0.4
Delay disc. indifference point, 16s delay	1.6	1.7	2.8	0.9	0.6	1.5	-1.5	-1.7
Delay disc. indifference point, 2s delay	2.2	2.4	3.0	1.7	1.6	1.7	-1.7	0.8
Delay disc. indifference point, 24s delay	0.6	0.7	0.8	-0.9	-0.9	-0.8	0.8	-0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.4	0.3	0.6	-0.6	-0.6
Delay disc. indifference point, 8s delay	0.8	1.0	1.6	0.8	0.7	1.3	-1.3	-0.7
Indifference point function ln k	0.4	0.7	0.9	-0.9	-0.8	-1.0	1.0	-0.3
Indifference point function log k	0.4	0.7	0.9	-0.9	-0.8	-1.0	1.0	-0.3
Patch foraging total patch changes 0 sec	0.3	0.6	1.2	0.8	0.9	0.5	-0.5	1.1
Patch foraging total patch changes 12 sec	0.1	0.2	0.2	0.4	0.4	0.5	-0.5	-0.0
Patch foraging total patch changes 18 sec	1.5	2.3	2.7	1.6	1.6	1.4	-1.4	1.4
Patch foraging total patch changes 24 sec	1.7	2.9	3.4	1.8	1.8	1.6	-1.6	1.6
Patch foraging total patch changes 6 sec	2.7	4.0	5.0	2.2	2.2	2.2	-2.2	1.1
Patch foraging time to switch 0 sec	1.2	2.4	3.0	-1.7	-1.7	-1.3	1.3	-1.6
Patch foraging water rate 0 sec	1.3	2.8	3.3	1.8	1.8	1.5	-1.5	1.6
Patch foraging water rate 12 sec	0.1	0.3	0.5	-0.4	-0.4	-0.7	0.7	0.4
Patch foraging water rate 18 sec	0.4	0.7	0.9	-0.8	-0.8	-0.9	0.9	-0.6
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.4	0.4	0.6	-0.6	-0.2
Patch foraging water rate 6 sec	1.0	1.5	1.8	1.3	1.3	1.1	-1.1	1.3
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	2.8	1.5	1.4	1.7	-1.7	0.1
Distance traveled before self-admin	3.2	4.2	4.8	2.2	2.2	2.2	-2.2	1.5
Distance traveled after self-admin	0.1	0.1	0.1	0.3	0.3	0.4	-0.4	0.1
Extensor digitorum longus weight	0.7	2.9	3.3	-1.8	-1.8	-1.7	1.7	-1.5
Bone: elastic displacement	2.7	3.1	3.5	1.9	1.9	1.9	-1.9	1.2
Bone: elastic work	7.3	9.5	11.3	3.4	3.3	3.3	-3.3	2.0
Bone: endosteal estimation	0.0	0.1	0.3	-0.1	-0.1	0.2	-0.2	-0.5
Bone: endosteal perimeter	0.1	0.2	1.0	-0.3	-0.4	-0.0	0.0	-1.0
Epididymis fat weight	7.6	26.0	29.1	-5.4	-5.4	-5.3	5.3	-4.1
Delta time in closed arm before/after self-admin	2.9	2.7	3.2	1.8	1.8	1.6	-1.6	1.4
Delta time in open arm before/after self-admin	6.4	6.3	7.5	-2.6	-2.7	-2.3	2.3	-2.5
Diff in mean of infusions in LGA sessions	0.5	0.6	0.7	-0.9	-0.9	-0.8	0.8	-0.6
Delay discount exponential model param	1.1	1.2	2.0	-1.0	-0.8	-1.4	1.4	0.8
Extinction: sum of active levers before priming	0.8	0.9	1.3	-1.0	-0.9	-1.2	1.2	-0.2
Active lever presses in extinction session 6	0.7	0.7	2.0	-0.3	-0.1	-0.8	0.8	1.4
Bone: final force	0.2	0.4	0.6	0.6	0.6	0.8	-0.8	-0.1
Bone: final moment	0.3	0.4	0.7	0.7	0.6	0.8	-0.8	-0.1
Food consumed during 24 hour testing period	0.4	0.6	1.7	0.6	0.7	0.3	-0.3	1.3
Glucose	1.2	1.9	2.3	1.5	1.5	1.4	-1.4	0.9
Heart weight	1.3	2.0	2.9	-1.5	-1.4	-1.7	1.7	-0.3
Delay discount hyperbolic model param	1.4	1.5	2.4	-1.2	-1.1	-1.6	1.6	0.4
Intermittent access intake day 1-15 change	0.0	0.1	0.2	-0.1	-0.0	-0.3	0.3	0.5
Intermittent access intake escalation	0.0	0.1	0.1	-0.3	-0.2	-0.4	0.4	0.1
Intermittent access intake escalation 2	0.1	0.2	0.2	0.4	0.4	0.4	-0.4	0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.3	0.3	0.4	-0.4	0.0
Intermitt. access day 15 inactive lever presses	0.3	0.6	0.7	0.8	0.8	0.7	-0.7	0.7
Intermitt. access escalation Index	0.9	1.3	2.3	-1.1	-1.2	-0.9	0.9	-1.5
Intermittent access day 1 total infusions	0.3	0.6	1.7	-0.6	-0.8	-0.2	0.2	-1.3
Intermittent access day 15 total infusions	1.0	1.4	2.1	-1.2	-1.3	-1.0	1.0	-1.4
Intermittent access terminal intake (last 3 days)	1.2	1.6	2.4	-1.3	-1.4	-1.0	1.0	-1.5
Intermittent access total infusions	0.5	0.6	1.5	-0.8	-0.9	-0.4	0.4	-1.2
Intermittent access day 1 locomotion	0.2	0.3	1.3	-0.3	-0.4	0.0	-0.0	-1.1
Intermittent access day 15 total locomotion	0.3	0.6	0.7	-0.8	-0.8	-0.7	0.7	-0.8
Intermittent access total locomotion	0.7	0.8	1.1	-0.9	-1.0	-0.7	0.7	-1.0
Intermittent access standard deviation	0.1	0.2	0.7	-0.1	-0.2	0.2	-0.2	-0.8
Left kidney weight	0.1	0.3	0.5	-0.5	-0.5	-0.4	0.4	-0.7
Right kidney weight	0.2	0.8	0.8	-0.9	-0.9	-0.8	0.8	-0.9
Cocaine induced anxiety	0.1	0.2	0.2	0.4	0.4	0.5	-0.5	0.2
Post-drug Anxiety	0.2	0.2	0.3	-0.3	-0.2	-0.5	0.5	0.5
Baseline Anxiety	0.4	0.4	0.6	-0.4	-0.3	-0.8	0.8	0.7
Tail length	0.4	1.4	1.9	-1.3	-1.2	-1.4	1.4	-0.5
Length with tail	0.6	2.4	2.6	-1.6	-1.6	-1.6	1.6	-1.3
Length without tail	0.5	1.5	2.9	-1.2	-1.3	-1.0	1.0	-1.7
Times rat made contact with spout	0.2	0.3	1.1	0.3	0.4	0.1	-0.1	1.1
Lifetime Intake	0.9	1.2	3.0	-1.0	-1.1	-0.5	0.5	-1.7
Liver weight, left	4.5	7.4	8.6	-2.9	-2.9	-2.9	2.9	-1.9
Liver weight, right	3.6	6.2	7.2	-2.7	-2.6	-2.7	2.7	-1.7
Locomotor activity	0.0	0.0	0.0	0.2	0.2	0.0	-0.0	-0.0
Locomotor testing distance	0.0	0.1	0.1	0.3	0.3	0.2	-0.2	-0.1
Locomotor testing rearing	0.1	0.2	0.6	0.4	0.4	0.2	-0.2	0.8
Locomotion in novel chamber	2.1	2.7	3.8	1.7	1.6	1.9	-1.9	0.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.0	-0.0	-0.2	0.2	-0.2
Fecal boli incidents, locomotor time 1	1.2	1.7	2.5	-1.4	-1.3	-1.6	1.6	-0.2
Change in fecal boli incidents, locomotor task	0.5	0.5	1.6	0.2	0.0	0.6	-0.6	-1.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.2	-0.0
Bouts of movement, locomotor time 1	0.4	0.4	0.6	0.7	0.7	0.8	-0.8	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.4	0.4	0.3	-0.3	0.3
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.3	-0.2	-0.6	0.6	0.6
Distance moved, locomotor task time 1	0.3	0.4	0.6	0.5	0.4	0.8	-0.8	-0.6
Vertical activity count, locomotor time 1	0.2	0.5	1.7	0.2	-0.0	0.6	-0.6	-1.3
Time >=10cm from walls, locomotor time 2	0.9	1.3	1.8	-1.2	-1.2	-1.0	1.0	-1.3
Bouts of movement, locomotor time 2	0.3	0.4	0.5	0.7	0.7	0.6	-0.6	0.6
Total resting periods, locomotor time 2	0.1	0.2	0.5	0.4	0.4	0.2	-0.2	0.7
Rest time, locomotor task time 2	0.9	1.2	5.2	0.3	0.5	-0.4	0.4	2.3
Distance moved, locomotor task time 2	0.7	0.8	2.5	0.3	0.1	0.9	-0.9	-1.6
Vertical activity count, locomotor time 2	1.6	2.1	7.8	0.3	-0.1	1.2	-1.2	-2.8
Light reinforcement 1	0.0	0.0	0.1	0.1	0.0	0.1	-0.1	-0.4
Light reinforcement 2	0.3	0.4	0.6	0.7	0.7	0.8	-0.8	0.2
Bone: marrow area	0.0	0.1	0.3	-0.1	-0.1	0.2	-0.2	-0.5
Bone: maximum diameter	0.3	0.5	0.8	0.7	0.6	0.9	-0.9	-0.3
Bone: maximum force	0.4	0.7	1.1	0.9	0.8	1.0	-1.0	-0.1
Bone: maximum moment	0.5	0.9	1.3	1.0	0.9	1.1	-1.1	-0.1
Mean time between licks in bursts	0.3	0.8	1.0	-1.0	-1.0	-0.8	0.8	-0.9
Mean num. licks in bursts	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.0
Cd content in liver	0.6	0.7	1.0	0.8	0.7	1.0	-1.0	-0.2
Co content in liver	0.3	0.4	0.5	0.7	0.7	0.6	-0.6	0.3
Cu content in liver	1.7	2.0	2.6	1.5	1.5	1.2	-1.2	1.6
Fe content in liver	2.2	2.6	3.1	-1.7	-1.8	-1.6	1.6	-1.4
K content in liver	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.3	-0.5
Mg content in liver	0.6	0.6	0.7	0.8	0.8	0.7	-0.7	0.7
Mn content in liver	0.3	0.3	0.6	0.5	0.6	0.4	-0.4	0.7
Na content in liver	0.6	0.6	2.7	-0.4	-0.6	0.1	-0.1	-1.6
Rb content in liver	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.2	-0.5
Se content in liver	0.5	0.6	0.7	0.8	0.8	0.7	-0.7	0.8
Sr content in liver	0.3	0.3	0.4	-0.5	-0.5	-0.7	0.7	-0.1
Zn content in liver	0.4	0.5	0.6	-0.7	-0.8	-0.7	0.7	-0.7
Bone: minimum diameter	0.1	0.1	0.1	0.3	0.2	0.4	-0.4	-0.3
Time in familiar zone, hab. session 1	0.3	0.3	0.4	0.6	0.5	0.6	-0.6	-0.0
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.4	-0.3	-0.5	0.5	0.1
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.1	0.1	0.3	-0.3	-0.5
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.4	0.4	0.3	-0.3	0.3
Locomotion velocity, hab. session 1	0.3	0.4	0.5	0.7	0.7	0.7	-0.7	0.3
Time in familiar zone, hab. session 2	0.3	0.3	0.7	0.5	0.5	0.3	-0.3	0.8
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.3	0.2	0.5	-0.5	-0.5
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.3	0.4	0.2	-0.2	0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.4	0.4	0.4	0.2	-0.2	0.6
Novel to familiar place preference ratio	0.8	0.9	1.0	-1.0	-1.0	-0.9	0.9	-0.8
Novelty place preference	1.0	1.1	1.3	-1.1	-1.1	-1.1	1.1	-0.9
Time in novel zone, NPP test	1.1	1.2	1.4	-1.2	-1.2	-1.1	1.1	-0.9
Total zone transitions, NPP test	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1	-0.3
Total locomotion distance, NPP test	0.8	1.1	1.3	1.1	1.1	1.0	-1.0	0.9
Locomotion velocity, NPP test	0.9	1.3	1.5	1.2	1.2	1.2	-1.2	1.0
Intraocular pressure	1.1	1.6	1.8	1.3	1.3	1.3	-1.3	1.2
Delta distance traveled before/after self-admin	2.8	3.0	3.4	-1.8	-1.8	-1.8	1.8	-1.3
Delta ambulatory time before/after self-admin	2.1	2.6	2.9	-1.7	-1.7	-1.6	1.6	-1.5
Parametrial fat weight	5.4	12.6	14.8	-3.8	-3.7	-3.9	3.9	-2.2
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.2	0.3
Pavlov. Cond. magazine entry latency	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.1	-0.5
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	0.6	0.6	0.6	-0.6	0.3
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.0	0.2	-0.2	-0.4
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.0	-0.1	0.1	-0.1	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.0	-0.1	0.2	-0.2	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	-0.3	-0.5	0.5	0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	0.5	0.6	0.4	-0.4	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.2	0.1	0.4	-0.4	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.0	-0.1	0.2	-0.2	-0.5
Pavlov. Cond. lever latency	2.3	3.1	3.6	-1.9	-1.9	-1.7	1.7	-1.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	0.3
Pavlov. Cond. change in total contacts	1.1	1.8	2.1	1.5	1.5	1.4	-1.4	1.1
Pavlov. Cond. index score	2.0	2.8	3.2	1.8	1.8	1.7	-1.7	1.3
Pavlov. Cond. latency score	2.4	3.2	3.7	1.9	1.9	1.8	-1.8	1.5
Pavlov. Cond. lever contacts	1.3	1.8	2.2	1.4	1.5	1.2	-1.2	1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.2	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.8	-0.8	-0.8	-0.9	0.9	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.1	2.4	1.5	1.5	1.5	-1.5	1.1
Pavlov. Cond. response bias	1.0	1.4	1.7	1.3	1.3	1.2	-1.2	1.0
Time in closed arm before self-admin	1.7	2.2	3.8	-1.5	-1.6	-1.1	1.1	-2.0
Time in closed arm after self-admin	0.9	1.0	1.5	0.8	0.6	1.2	-1.2	-0.9
Time in open arm before self-admin	2.6	2.9	6.0	1.6	1.8	1.1	-1.1	2.4
Time in open arm after self-admin	0.9	0.9	1.2	-1.0	-1.0	-1.1	1.1	-0.5
Bone: periosteal estimation	0.3	0.6	0.9	0.8	0.7	1.0	-1.0	-0.2
Bone: periosteal perimeter	0.3	0.5	0.7	0.5	0.4	0.8	-0.8	-0.8
Bone: post-yield work	0.3	0.5	0.9	-0.7	-0.7	-0.5	0.5	-0.9
Progressive ratio test 1 active lever presses	0.4	0.5	0.8	0.6	0.5	0.9	-0.9	-0.4
Progressive ratio test 1 breakpoint	0.4	0.5	0.9	0.7	0.6	0.9	-0.9	-0.3
Progressive ratio test 1 inactive lever presses	1.2	1.8	2.8	1.3	1.1	1.7	-1.7	-0.5
Progressive ratio test 2 active lever presses	0.3	0.3	0.4	0.6	0.5	0.6	-0.6	0.3
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	0.6	0.5	0.6	-0.6	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.3	0.3	0.4	-0.4	-0.2
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.2	0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	-0.1	-0.1	-0.3	0.3	0.7
Sum of active levers in priming session hrs 5-6	1.4	1.3	1.7	-1.2	-1.1	-1.3	1.3	-0.4
Progressive ratio	0.3	0.4	1.8	-0.0	0.1	-0.4	0.4	1.3
Food seeking constrained by brief footshock	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.4	-0.2
Seeking ratio, punishment vs. effort	0.3	0.5	2.0	0.1	-0.0	0.4	-0.4	-1.4
Retroperitoneal fat weight	0.6	2.4	2.7	-1.6	-1.6	-1.4	1.4	-1.7
Reaction time number correct	0.6	1.2	1.3	-1.1	-1.2	-1.1	1.1	-0.8
Reaction time mean minus median	0.1	0.2	0.3	-0.5	-0.5	-0.6	0.6	-0.1
Reaction time mean minus median AUC	0.8	2.1	2.6	-1.6	-1.6	-1.4	1.4	-1.4
Reaction time num false alarms	5.2	7.3	8.6	2.9	2.9	2.7	-2.7	2.3
Reaction time num false alarms AUC	4.8	7.5	8.9	3.0	3.0	2.7	-2.7	2.3
Reaction time trials correct on left	0.6	1.2	1.3	-1.1	-1.2	-1.1	1.1	-0.8
Reaction time trials on left	0.6	1.2	1.4	-1.2	-1.2	-1.1	1.1	-0.9
Reaction time mean	0.5	0.8	1.0	-1.0	-1.0	-0.9	0.9	-0.5
Reaction time mean AUC	0.4	0.6	0.8	-0.9	-0.9	-0.8	0.8	-0.6
Median of all reaction times	0.4	0.5	0.7	-0.8	-0.8	-0.8	0.8	-0.4
Reaction time omissions	1.2	1.7	2.0	-1.4	-1.4	-1.3	1.3	-1.2
Reaction time false alarm rate	5.5	7.6	9.0	3.0	3.0	2.7	-2.7	2.3
Reaction time premature initiation rate	0.3	0.4	1.0	-0.6	-0.6	-0.4	0.4	-1.0
Reaction time premature initiations	0.4	0.7	1.1	-0.8	-0.9	-0.7	0.7	-1.1
Std. dev. reaction times	0.6	1.0	1.2	-1.1	-1.1	-1.1	1.1	-0.6
Reaction time trials completed	0.6	1.2	1.4	-1.2	-1.2	-1.1	1.1	-0.9
Reaction time trials AUC	0.5	0.9	1.1	-1.0	-1.0	-1.0	1.0	-0.7
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.0
Run reversals in cocaine runway, males	0.2	0.2	0.8	-0.3	-0.3	-0.2	0.2	-0.9
Latency to leave start box in cocaine runway	2.2	2.5	10.0	0.9	1.1	0.3	-0.3	3.2
Latency to leave start box in cocaine runway, F	1.0	1.1	5.0	0.4	0.6	-0.2	0.2	2.2
Latency to leave start box in cocaine runway, M	1.1	1.0	4.0	0.6	0.7	0.4	-0.4	2.0
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.2	-0.2	0.0	-0.0	-0.5
Total sessions with >9 infusions	1.2	1.4	5.4	-0.8	-1.0	-0.2	0.2	-2.3
Short access day 1 total inactive lever presses	3.8	5.0	7.2	-2.3	-2.4	-1.9	1.9	-2.7
Short access day 10 total inactive lever presses	0.1	0.1	0.6	0.0	-0.0	0.2	-0.2	-0.8
Short access day 1 total infusions	1.6	2.2	7.7	-1.1	-1.3	-0.4	0.4	-2.8
Short access day 10 total infusions	0.8	1.0	3.5	-0.8	-1.0	-0.3	0.3	-1.9
Short access total infusions	0.9	1.2	4.8	-0.6	-0.8	0.0	-0.0	-2.2
Short access day 1 locomotion	0.4	0.5	2.3	-0.1	-0.2	0.4	-0.4	-1.5
Short access day 10 total locomotion	0.3	0.5	0.7	0.8	0.7	0.8	-0.8	0.1
Short access total locomotion	0.5	0.6	0.9	0.6	0.4	0.9	-0.9	-0.9
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.1	0.1	0.3	-0.3	-0.1
Compulsive drug intake	0.9	1.1	1.3	-1.1	-1.1	-1.0	1.0	-1.0
One hour access (shock baseline)	0.1	0.1	0.2	0.4	0.4	0.4	-0.4	0.2
Social response proportion	2.4	2.7	3.5	-1.8	-1.8	-1.4	1.4	-1.9
Social responses	1.9	2.4	2.7	-1.6	-1.7	-1.5	1.5	-1.3
Social time	1.7	2.3	4.2	-1.5	-1.6	-1.1	1.1	-2.0
Soleus weight	2.1	6.2	7.1	-2.7	-2.7	-2.5	2.5	-2.0
Bone: stiffness	1.8	2.9	3.4	-1.8	-1.8	-1.6	1.6	-1.6
Tibialis anterior weight	2.5	8.6	9.8	-3.1	-3.1	-3.1	3.1	-2.1
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.5	-0.4	-0.5	-0.0	0.0	-1.2
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.6	0.6	0.5	0.8	-0.8	-0.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.0	0.0	-0.1	0.1	0.3
Time to tail flick, test, after self-admin	2.1	2.2	8.7	0.9	1.1	0.2	-0.2	2.9
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.9	0.7	0.8	0.4	-0.4	1.4
Delta time to tail flick, test, before/after SA	0.6	0.6	1.0	0.8	0.8	0.6	-0.6	1.0
Tibia length	0.0	0.1	0.1	0.2	0.1	0.3	-0.3	-0.3
Ambulatory time before self-admin	1.3	1.9	2.9	1.4	1.3	1.7	-1.7	0.0
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	-0.1	0.0	-0.0	-0.4
Bone: tissue strength	1.4	1.4	1.9	1.3	1.2	1.4	-1.4	0.4
Total heroin consumption	3.0	3.5	5.7	-1.8	-1.5	-2.4	2.4	0.8
Bone: trabecular number	2.5	4.2	5.4	-2.2	-2.1	-2.3	2.3	-0.8
Bone: trabecular spacing	0.2	0.3	0.4	0.6	0.5	0.7	-0.7	0.0
Bone: trabecular thickness	0.0	0.0	0.1	0.0	-0.0	0.1	-0.1	-0.3
Bone: trabecular tissue density	1.1	1.7	1.9	1.4	1.4	1.4	-1.4	0.9
Water consumed over 24 hours	0.0	0.1	0.1	0.2	0.2	0.2	-0.2	0.3
Number of responses in last shaping day	1.0	1.1	1.6	1.1	0.9	1.3	-1.3	-0.6