Hub : Genes

Tmco4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio NM_001034949.1 0.04 0.04 1.2e-03 0.03 0.03 0.04 0.03 4.7e-04 6.2e-04 2.4e-04 6.0e-04
2 Brain isoform ratio XM_039110634.1 0.04 0.04 1.3e-03 0.03 0.03 0.05 0.03 4.1e-04 8.3e-04 1.5e-05 7.2e-04
3 Liver alternative polyA XM_039110634.1 0.07 0.07 1.2e-07 0.06 0.05 0.06 0.06 9.4e-07 1.2e-06 4.6e-07 6.0e-07
4 Liver alternative polyA NM_001034949.1 0.03 0.04 3.6e-04 0.02 0.02 0.03 0.02 1.3e-03 1.2e-03 7.8e-04 1.1e-03
5 pVTA gene expression Tmco4 0.08 0.1 7.8e-03 0.03 0.02 0.02 0.02 2.6e-02 3.2e-02 3.1e-02 3.5e-02
6 Liver isoform ratio NM_001034949.1 0.02 0.02 7.5e-03 0.01 0.01 0.01 0.01 9.9e-03 2.4e-02 9.6e-03 1.4e-02
7 Liver isoform ratio XM_039110634.1 0.06 0.06 7.6e-07 0.04 0.04 0.05 0.04 1.5e-05 1.1e-05 5.5e-06 8.0e-06
8 Brain mRNA stability Tmco4 0.08 0.07 1.0e-06 0.07 0.07 0.06 0.07 5.8e-07 7.6e-07 2.3e-06 8.5e-07
9 Liver mRNA stability Tmco4 0.02 0.02 6.0e-03 0.01 0.01 0.01 0.01 1.7e-02 2.1e-02 4.6e-02 2.7e-02
10 BLA gene expression Tmco4 0.47 0.24 7.6e-04 0.04 0.05 0.05 0.04 3.2e-03 9.9e-04 1.3e-03 3.7e-03
11 Brain alternative polyA XM_039110634.1 0.03 0.03 8.4e-03 0.02 0.02 0.03 0.02 4.9e-03 6.3e-03 1.2e-03 6.2e-03
12 Liver gene expression Tmco4 0.14 0.12 6.0e-14 0.1 0.11 0.11 0.1 2.7e-11 4.5e-12 4.7e-12 1.2e-11
13 Brain gene expression Tmco4 0.04 0.04 5.6e-04 0.03 0.03 0.03 0.03 4.7e-04 3.4e-04 6.4e-04 5.3e-04
14 PL gene expression Tmco4 0.11 0.17 2.9e-03 0.01 0.02 0.02 0.01 1.9e-02 4.0e-03 5.4e-03 2.9e-02
15 PL alternative polyA XM_039110634.1 0.03 0.02 1.7e-03 0.01 0.01 0.01 0.01 2.4e-02 9.8e-03 3.2e-02 3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.03.11.3-1.81.0-1.0-1.0-1.01.0-1.0-1.00.7-1.00.70.70.7-0.7
Area under the delay curve0.10.10.40.10.00.5-0.5-0.5-0.50.5-0.2-0.20.6-0.10.20.20.3-0.2
BMI with tail0.72.28.32.9-2.5-1.11.11.11.1-1.11.01.0-0.8-2.2-1.3-1.3-1.11.3
BMI without tail0.61.23.71.9-1.4-0.80.80.80.8-0.80.80.8-0.8-1.5-1.1-1.2-1.01.1
Body weight2.29.415.13.5-3.9-2.92.93.03.0-3.02.82.8-2.6-3.6-3.0-3.0-2.93.0
Weight adjusted by age0.10.10.20.00.3-0.30.30.30.3-0.30.10.1-0.0-0.0-0.4-0.4-0.20.4
Bone surface0.20.42.61.2-1.6-0.10.20.20.2-0.20.20.2-0.3-1.0-0.4-0.4-0.40.4
Bone volume0.10.21.50.8-1.20.3-0.3-0.3-0.30.3-0.3-0.30.1-0.70.10.10.1-0.1
Breakpoint value in progressive ratio session0.20.20.50.30.00.5-0.5-0.4-0.40.4-0.4-0.40.7-0.10.40.40.5-0.4
Number of licking bursts2.63.14.9-1.32.21.9-1.8-1.9-1.91.9-1.7-1.71.41.61.81.71.6-1.7
Context. condit. distance diff. score0.60.71.8-1.31.1-0.70.70.70.7-0.70.60.6-1.01.1-0.7-0.7-0.80.7
Locomotion velocity, session 11.21.31.7-1.00.11.2-1.3-1.2-1.21.2-1.1-1.11.20.81.31.31.3-1.3
Locomotion distance, session 15.97.68.3-2.62.42.9-2.9-2.9-2.92.9-2.8-2.82.22.62.92.92.6-2.8
Locomotion velocity, session 28.610.010.5-3.23.23.2-3.2-3.2-3.23.2-3.1-3.13.03.03.23.23.1-3.2
Locomotion distance, session 23.14.35.4-1.31.32.3-2.3-2.3-2.32.3-2.3-2.32.11.22.12.12.1-2.1
Locomotion velocity, session 30.91.11.6-1.20.71.1-1.1-1.1-1.11.1-1.3-1.30.80.81.01.00.9-0.9
Locomotion distance, session 32.83.15.9-2.41.61.7-1.7-1.7-1.71.7-1.9-1.91.32.21.51.51.4-1.5
Stereotopy head waving bouts, day 32.02.45.51.6-2.3-1.41.41.41.4-1.41.51.5-1.5-2.1-1.2-1.2-1.41.3
Stereotopy head waving duration, day 30.60.71.60.8-1.3-0.80.80.80.8-0.80.80.8-0.9-1.3-0.5-0.5-0.60.5
Locomotion velocity, session 71.41.57.1-2.72.50.6-0.5-0.5-0.50.5-0.7-0.70.32.50.30.30.3-0.3
Locomotion distance, session 74.76.08.1-2.62.82.5-2.4-2.4-2.42.4-2.6-2.62.22.82.22.22.2-2.2
Stereotopy head waving bouts, day 70.30.30.90.9-0.4-0.60.60.60.6-0.60.50.5-0.5-0.7-0.5-0.5-0.50.5
Stereotopy head waving duration, day 70.20.30.60.8-0.2-0.60.60.60.6-0.60.50.5-0.5-0.7-0.5-0.5-0.50.5
Locomotion velocity, session 80.40.52.0-0.61.40.6-0.6-0.6-0.60.6-0.6-0.60.61.00.40.40.5-0.4
Locomotion distance, session 80.91.34.1-2.01.81.0-1.0-1.0-1.01.0-1.1-1.10.71.60.90.90.8-0.9
Degree of sensitization distance0.10.10.30.40.40.4-0.4-0.4-0.40.4-0.3-0.30.6-0.10.30.30.4-0.4
Degree of sensitization stereotypy1.01.12.01.4-1.2-0.90.90.90.9-0.90.80.8-1.0-1.4-1.0-1.0-1.01.0
Conditioned locomotion0.10.10.6-0.80.70.2-0.2-0.2-0.20.2-0.3-0.30.10.30.20.20.1-0.2
Cocaine response after cond. corrected0.20.21.0-1.00.50.3-0.3-0.3-0.30.3-0.4-0.40.30.70.40.40.4-0.4
Cocaine response after cond. not corrected0.20.20.8-0.90.60.3-0.3-0.3-0.30.3-0.3-0.30.40.50.40.40.4-0.4
Cocaine response before conditioning0.10.10.7-0.20.90.3-0.3-0.3-0.30.3-0.2-0.20.40.20.20.20.3-0.2
Saline control response1.01.31.9-0.10.21.3-1.3-1.3-1.31.3-1.2-1.21.40.31.31.21.3-1.3
Bone: connectivity density0.20.42.61.3-1.60.1-0.1-0.1-0.10.1-0.1-0.1-0.1-1.0-0.1-0.1-0.10.1
Bone: cortical apparent density1.01.32.2-1.31.51.2-1.2-1.2-1.21.2-1.1-1.11.01.31.01.01.0-1.0
Bone: cortical area1.01.55.51.6-2.3-0.91.00.90.9-0.90.90.9-1.0-1.7-1.0-1.0-1.01.0
Bone: cortical porosity0.40.51.21.0-1.10.6-0.6-0.6-0.60.6-0.6-0.60.5-1.00.50.50.5-0.5
Bone: cortical porosity0.30.41.51.2-1.20.3-0.3-0.3-0.30.3-0.2-0.20.3-1.20.30.30.3-0.3
Bone: cortical thickness0.30.54.51.2-2.10.2-0.2-0.2-0.20.2-0.2-0.20.1-1.30.00.00.0-0.0
Bone: cortical thickness0.80.93.41.0-1.8-0.80.80.80.8-0.80.70.7-0.8-1.4-0.9-0.9-0.90.9
Bone: cortical tissue density1.21.52.8-1.41.71.3-1.2-1.2-1.21.2-1.2-1.21.01.51.01.01.0-1.0
Condit. Reinf. active minus inactive responses5.46.110.2-2.33.22.4-2.4-2.4-2.42.4-2.5-2.52.22.52.52.52.4-2.5
Condit. Reinf. active-inactive response ratio4.24.610.5-2.43.22.0-2.0-2.0-2.02.0-2.0-2.01.92.52.02.02.0-2.0
Condit. Reinf. active responses4.65.76.7-1.92.52.4-2.4-2.4-2.42.4-2.6-2.62.02.12.62.62.3-2.5
Condit. Reinf. inactive responses0.20.20.90.9-0.90.2-0.2-0.2-0.20.2-0.4-0.4-0.2-0.60.30.30.1-0.3
Incentive salience index mean2.42.94.6-1.72.11.7-1.7-1.7-1.71.7-1.8-1.81.31.51.71.71.6-1.7
Condit. Reinf. lever presses0.20.31.2-1.10.70.5-0.5-0.5-0.50.5-0.6-0.60.10.40.50.50.3-0.5
Condit. Reinf. active minus inactive responses0.91.11.31.1-1.1-0.91.00.90.9-0.91.01.0-0.9-1.0-1.2-1.2-1.11.1
Condit. Reinf. active-inactive response ratio0.20.21.40.8-1.2-0.20.30.30.3-0.30.30.3-0.3-0.7-0.3-0.3-0.30.3
Condit. Reinf. active responses0.00.00.20.10.5-0.00.10.00.0-0.00.10.10.00.2-0.2-0.2-0.10.2
Condit. Reinf. inactive responses1.72.17.9-1.92.81.2-1.1-1.2-1.21.2-1.1-1.11.22.21.11.11.1-1.1
Condit. Reinf. lever presses0.10.10.5-0.30.7-0.30.40.30.3-0.30.30.3-0.10.3-0.4-0.4-0.30.4
Condit. Reinf. lever reinforcers received0.20.30.50.7-0.2-0.40.50.50.5-0.50.50.5-0.3-0.4-0.6-0.6-0.50.6
Conditioned reinforcement - actives2.42.44.62.10.52.1-1.9-2.0-2.02.0-2.0-2.01.40.10.60.50.8-0.5
Conditioned reinforcement - inactives0.10.10.40.20.4-0.10.10.10.1-0.10.10.1-0.30.6-0.1-0.1-0.20.1
Conditioned locomotion1.92.23.80.51.31.9-1.8-1.9-1.91.9-1.9-1.91.41.20.90.91.0-0.9
Patch foraging indifference point 0 sec2.64.15.1-0.81.12.2-2.2-2.2-2.22.2-2.3-2.32.31.62.12.12.2-2.1
Patch foraging indifference point AUC0.30.40.70.2-0.30.7-0.7-0.7-0.70.7-0.7-0.70.8-0.10.60.60.7-0.7
Delay disc. indifference point, 0s delay3.43.88.0-1.01.22.2-2.2-2.1-2.12.1-2.0-2.02.80.71.81.82.2-1.8
Delay disc. indifference point, 16s delay0.00.00.10.3-0.2-0.00.00.00.0-0.00.30.30.2-0.2-0.0-0.00.10.0
Delay disc. indifference point, 2s delay0.20.21.00.3-0.10.5-0.5-0.5-0.50.5-0.3-0.31.0-0.60.10.00.4-0.1
Delay disc. indifference point, 24s delay0.50.51.4-0.30.40.7-0.7-0.7-0.70.7-0.6-0.61.20.20.70.70.9-0.8
Delay disc. indifference point, 4s delay0.00.00.20.3-0.30.0-0.0-0.0-0.00.00.00.00.0-0.4-0.3-0.3-0.20.3
Delay disc. indifference point, 8s delay0.10.10.20.2-0.2-0.10.10.10.1-0.10.40.4-0.5-0.0-0.3-0.3-0.40.3
Indifference point function ln k0.10.10.4-0.70.5-0.10.10.00.0-0.00.10.1-0.50.60.00.0-0.2-0.0
Indifference point function log k0.10.10.4-0.70.5-0.10.10.00.0-0.00.10.1-0.50.60.00.0-0.2-0.0
Patch foraging total patch changes 0 sec2.94.65.7-1.01.22.3-2.3-2.3-2.32.3-2.4-2.42.41.82.32.22.3-2.3
Patch foraging total patch changes 12 sec2.12.73.7-0.10.21.8-1.9-1.8-1.81.8-1.9-1.91.90.41.81.81.8-1.8
Patch foraging total patch changes 18 sec4.55.87.4-0.60.92.6-2.6-2.6-2.62.6-2.7-2.72.61.92.62.62.6-2.6
Patch foraging total patch changes 24 sec4.85.910.1-0.60.62.6-2.6-2.6-2.62.6-2.7-2.73.20.72.72.72.9-2.7
Patch foraging total patch changes 6 sec1.72.63.2-1.20.91.6-1.7-1.6-1.61.6-1.7-1.71.81.51.71.71.7-1.7
Patch foraging time to switch 0 sec0.61.01.50.2-0.2-1.01.01.01.0-1.01.11.1-1.2-0.1-1.1-1.1-1.21.1
Patch foraging water rate 0 sec1.82.93.8-0.60.11.9-1.9-1.9-1.91.9-1.9-1.91.90.31.91.91.9-1.9
Patch foraging water rate 12 sec2.43.74.6-1.40.52.0-2.0-2.1-2.12.1-2.0-2.02.11.22.12.12.1-2.1
Patch foraging water rate 18 sec0.70.91.4-0.3-0.31.0-1.0-1.0-1.01.0-1.1-1.10.90.11.21.21.1-1.2
Patch foraging water rate 24 sec1.41.92.7-1.20.71.4-1.5-1.4-1.41.4-1.5-1.51.20.91.71.61.5-1.6
Patch foraging water rate 6 sec2.43.54.4-1.01.02.0-2.0-2.0-2.02.0-2.0-2.02.11.02.02.02.1-2.0
Seeking ratio, delayed vs. immediate footshock3.03.43.91.6-1.5-1.91.91.91.9-1.92.02.0-1.8-1.6-1.9-1.9-1.91.9
Distance traveled before self-admin0.40.51.51.2-0.9-0.50.50.50.5-0.50.50.5-0.8-0.6-0.6-0.6-0.70.6
Distance traveled after self-admin0.40.41.4-0.9-0.2-0.60.60.60.6-0.60.60.6-1.20.1-0.4-0.4-0.70.5
Extensor digitorum longus weight0.00.10.6-0.3-0.7-0.20.20.20.2-0.20.10.1-0.3-0.2-0.1-0.1-0.20.1
Bone: elastic displacement8.19.213.6-3.03.73.0-3.0-3.0-3.03.0-3.0-3.02.93.03.03.02.9-2.9
Bone: elastic work3.74.88.7-2.62.92.1-2.1-2.1-2.12.1-2.1-2.11.92.62.02.02.0-2.0
Bone: endosteal estimation2.04.35.40.9-1.2-2.32.32.32.3-2.32.22.2-2.1-1.2-2.2-2.2-2.22.2
Bone: endosteal perimeter1.32.63.21.2-1.2-1.81.81.81.8-1.81.71.7-1.6-1.1-1.7-1.7-1.71.7
Epididymis fat weight3.37.69.23.0-2.8-2.72.72.82.8-2.82.72.7-2.4-3.0-2.8-2.8-2.72.8
Delta time in closed arm before/after self-admin0.60.62.30.9-1.1-0.70.70.70.7-0.70.70.70.3-1.5-0.7-0.6-0.30.6
Delta time in open arm before/after self-admin0.40.34.1-2.00.5-0.20.20.10.1-0.10.10.1-0.40.70.10.1-0.1-0.1
Diff in mean of infusions in LGA sessions0.70.77.52.7-0.9-0.20.30.30.3-0.30.30.30.1-1.1-0.6-0.6-0.30.6
Delay discount exponential model param0.00.00.1-0.30.2-0.20.20.20.2-0.2-0.1-0.1-0.40.30.10.1-0.1-0.1
Extinction: sum of active levers before priming4.84.85.5-1.61.32.3-2.3-2.3-2.32.3-2.3-2.32.31.52.32.32.3-2.3
Active lever presses in extinction session 60.30.31.21.10.20.6-0.6-0.6-0.60.6-0.6-0.60.30.40.40.40.4-0.4
Bone: final force1.72.73.71.6-1.9-1.61.61.61.6-1.61.51.5-1.6-1.8-1.7-1.7-1.71.7
Bone: final moment1.42.23.01.5-1.7-1.41.51.51.5-1.51.41.4-1.4-1.6-1.5-1.5-1.51.5
Food consumed during 24 hour testing period1.31.62.20.8-0.5-1.41.41.41.4-1.41.51.5-0.9-1.0-1.3-1.3-1.11.3
Glucose0.40.61.7-1.30.90.6-0.6-0.6-0.60.6-0.6-0.60.81.30.80.80.8-0.8
Heart weight0.10.10.5-0.50.5-0.10.10.10.1-0.1-0.0-0.0-0.50.7-0.2-0.2-0.30.2
Delay discount hyperbolic model param0.10.10.2-0.40.3-0.10.10.10.1-0.1-0.1-0.1-0.30.50.20.20.0-0.2
Intermittent access intake day 1-15 change1.71.72.80.8-0.7-1.21.31.21.2-1.21.21.2-1.4-0.8-1.7-1.7-1.61.7
Intermittent access intake escalation1.81.83.01.7-1.1-1.11.21.11.1-1.11.11.1-1.1-1.4-1.7-1.7-1.51.7
Intermittent access intake escalation 20.60.62.01.4-0.7-0.40.50.50.5-0.50.50.5-0.5-1.0-1.1-1.1-0.91.0
Intermitt. access day 1 inactive lever presses0.60.71.40.0-0.2-1.21.11.11.1-1.11.11.1-0.5-0.1-0.5-0.5-0.50.5
Intermitt. access day 15 inactive lever presses0.10.10.50.30.50.0-0.1-0.1-0.10.1-0.1-0.10.40.70.40.40.4-0.4
Intermitt. access escalation Index3.22.86.4-1.30.91.8-1.9-1.8-1.81.8-1.8-1.82.50.21.41.41.9-1.5
Intermittent access day 1 total infusions2.93.44.61.11.12.1-2.1-2.1-2.12.1-2.1-2.12.11.01.71.71.9-1.7
Intermittent access day 15 total infusions0.80.93.51.90.31.2-1.1-1.1-1.11.1-1.1-1.11.2-0.20.20.10.5-0.2
Intermittent access terminal intake (last 3 days)1.41.54.62.10.41.5-1.4-1.4-1.41.4-1.4-1.41.6-0.10.40.40.8-0.5
Intermittent access total infusions2.02.23.51.50.81.9-1.8-1.8-1.81.8-1.8-1.81.70.51.00.91.2-1.0
Intermittent access day 1 locomotion2.02.13.81.00.81.7-1.7-1.6-1.61.6-1.6-1.61.90.51.21.21.5-1.2
Intermittent access day 15 total locomotion0.30.31.81.40.30.5-0.5-0.5-0.50.5-0.5-0.50.50.1-0.1-0.10.10.1
Intermittent access total locomotion1.82.03.31.40.91.8-1.7-1.7-1.71.7-1.7-1.71.60.60.90.91.1-0.9
Intermittent access standard deviation0.20.21.41.20.20.5-0.4-0.4-0.40.4-0.4-0.40.30.2-0.1-0.10.00.1
Left kidney weight1.13.24.00.2-1.1-2.02.02.02.0-2.01.81.8-1.9-1.1-1.9-2.0-2.02.0
Right kidney weight0.82.33.00.2-0.3-1.71.71.71.7-1.71.71.7-1.7-0.6-1.6-1.7-1.71.7
Cocaine induced anxiety0.10.10.40.30.20.2-0.2-0.2-0.20.2-0.2-0.20.70.10.10.10.3-0.2
Post-drug Anxiety0.40.53.31.80.00.4-0.5-0.4-0.40.4-0.4-0.41.2-0.20.40.40.8-0.5
Baseline Anxiety0.50.61.21.10.30.7-0.7-0.7-0.70.7-0.7-0.70.90.30.90.90.9-0.9
Tail length0.72.22.80.6-1.0-1.61.61.61.6-1.61.41.4-1.5-1.1-1.7-1.7-1.61.7
Length with tail1.55.36.41.5-2.2-2.52.52.52.5-2.52.32.3-2.3-1.8-2.3-2.3-2.32.3
Length without tail1.22.55.21.7-2.3-1.61.61.61.6-1.61.51.5-1.4-1.7-1.4-1.4-1.41.4
Times rat made contact with spout3.54.07.6-2.32.71.9-1.9-1.9-1.91.9-1.9-1.92.02.21.81.81.9-1.8
Lifetime Intake3.13.55.61.41.12.4-2.3-2.3-2.32.3-2.3-2.32.10.81.31.31.5-1.3
Liver weight, left0.50.84.62.1-1.7-0.20.10.20.2-0.20.20.20.1-1.9-0.2-0.2-0.00.1
Liver weight, right2.13.45.41.8-1.9-1.91.81.91.9-1.92.02.0-1.8-2.3-1.6-1.6-1.71.6
Locomotor activity0.10.10.2-0.3-0.4-0.40.50.40.4-0.40.40.4-0.50.0-0.3-0.4-0.40.4
Locomotor testing distance2.33.94.7-1.81.42.1-2.1-2.1-2.12.1-2.2-2.21.91.72.02.01.9-2.0
Locomotor testing rearing3.75.68.3-2.91.92.4-2.4-2.4-2.42.4-2.6-2.62.12.12.42.42.2-2.3
Locomotion in novel chamber0.10.10.4-0.20.1-0.40.40.40.4-0.40.20.20.4-0.6-0.5-0.5-0.10.4
Locomotion in novel chamber post-restriction0.70.81.80.8-0.7-0.90.90.90.9-0.90.90.9-0.2-1.3-1.0-1.0-0.71.0
Fecal boli incidents, locomotor time 10.20.21.20.6-0.30.1-0.1-0.1-0.10.1-0.0-0.01.1-0.9-0.2-0.20.30.1
Change in fecal boli incidents, locomotor task0.00.00.0-0.10.10.0-0.0-0.0-0.00.0-0.2-0.20.10.20.10.10.1-0.0
Time >=10cm from walls, locomotor time 17.98.015.61.8-2.0-3.03.03.03.0-3.03.03.0-3.9-1.4-2.7-2.7-3.22.8
Bouts of movement, locomotor time 10.80.91.50.7-0.7-0.80.80.80.8-0.80.80.8-1.2-0.8-1.2-1.2-1.21.2
Total resting periods, locomotor time 10.50.50.90.6-0.6-0.50.50.50.5-0.50.60.6-0.7-0.9-1.0-1.0-0.91.0
Rest time, locomotor task time 10.10.10.40.5-0.30.2-0.2-0.2-0.20.2-0.2-0.20.5-0.6-0.2-0.20.10.1
Distance moved, locomotor task time 11.71.93.3-1.61.31.3-1.3-1.3-1.31.3-1.3-1.30.61.81.61.61.2-1.5
Vertical activity count, locomotor time 10.50.51.8-1.10.80.5-0.5-0.5-0.50.5-0.7-0.7-0.61.40.60.60.1-0.5
Time >=10cm from walls, locomotor time 22.82.98.60.8-1.1-1.81.81.81.8-1.81.61.6-2.9-0.2-1.6-1.6-2.11.7
Bouts of movement, locomotor time 20.20.21.6-0.1-0.1-0.10.10.10.1-0.10.10.1-1.30.1-0.5-0.5-0.80.5
Total resting periods, locomotor time 20.10.10.7-0.30.10.2-0.2-0.2-0.20.2-0.1-0.1-0.90.3-0.1-0.1-0.40.2
Rest time, locomotor task time 20.10.10.40.2-0.00.2-0.2-0.2-0.20.2-0.2-0.20.6-0.40.10.10.3-0.1
Distance moved, locomotor task time 20.10.10.5-0.40.20.1-0.1-0.1-0.10.1-0.1-0.1-0.70.6-0.0-0.0-0.30.1
Vertical activity count, locomotor time 20.30.32.3-0.50.00.1-0.0-0.0-0.00.0-0.1-0.1-1.50.6-0.4-0.4-0.90.5
Light reinforcement 10.81.52.3-1.00.11.1-1.2-1.2-1.21.2-1.3-1.31.30.41.51.51.4-1.5
Light reinforcement 20.10.21.40.0-1.2-0.20.10.10.1-0.1-0.0-0.00.1-1.10.10.00.1-0.1
Bone: marrow area1.94.25.31.0-1.2-2.32.32.32.3-2.32.22.2-2.1-1.2-2.2-2.2-2.12.2
Bone: maximum diameter0.50.91.10.7-1.0-1.01.01.01.0-1.01.01.0-0.9-0.8-0.9-0.9-0.90.9
Bone: maximum force2.13.75.32.1-2.3-1.81.91.81.8-1.81.81.8-1.9-2.0-2.0-2.0-1.92.0
Bone: maximum moment1.83.24.41.9-2.1-1.71.71.71.7-1.71.71.7-1.7-1.8-1.8-1.8-1.81.8
Mean time between licks in bursts0.40.63.7-1.31.90.4-0.4-0.4-0.40.4-0.3-0.30.61.10.40.40.5-0.4
Mean num. licks in bursts0.30.40.6-0.0-0.6-0.70.70.70.7-0.70.60.6-0.2-0.4-0.7-0.6-0.50.6
Cd content in liver3.33.64.31.7-1.6-1.91.91.91.9-1.91.81.8-2.0-1.8-2.1-2.1-2.12.1
Co content in liver1.31.53.00.30.6-1.21.21.21.2-1.21.21.2-1.7-0.3-1.5-1.5-1.61.5
Cu content in liver0.50.63.9-1.52.00.3-0.3-0.3-0.30.3-0.3-0.30.21.50.40.50.4-0.4
Fe content in liver3.33.95.1-1.01.32.3-2.2-2.2-2.22.2-2.2-2.21.91.51.91.91.9-1.9
K content in liver1.01.01.30.10.8-1.21.21.21.2-1.21.01.0-0.90.5-1.0-1.0-1.01.0
Mg content in liver0.30.41.0-0.70.7-0.50.50.50.5-0.50.40.4-0.51.0-0.5-0.5-0.50.5
Mn content in liver4.14.77.22.7-2.6-2.12.12.12.1-2.12.12.1-1.8-2.3-2.1-2.1-1.92.1
Na content in liver0.50.51.8-1.01.4-0.70.60.60.6-0.60.50.5-0.41.0-0.4-0.4-0.40.4
Rb content in liver0.10.10.60.80.30.3-0.2-0.2-0.20.2-0.4-0.4-0.00.3-0.1-0.1-0.10.1
Se content in liver1.51.93.61.9-1.5-1.31.31.31.3-1.31.31.3-1.3-1.1-1.4-1.4-1.31.4
Sr content in liver0.30.33.41.8-0.30.1-0.1-0.1-0.10.1-0.1-0.1-0.1-0.5-0.3-0.3-0.30.3
Zn content in liver1.11.21.8-0.4-0.2-1.11.11.11.1-1.11.21.2-1.20.1-1.3-1.3-1.31.3
Bone: minimum diameter1.73.25.21.8-2.3-1.71.71.71.7-1.71.71.7-1.7-2.1-1.8-1.8-1.71.8
Time in familiar zone, hab. session 11.21.12.3-1.51.21.0-1.0-1.0-1.01.0-0.9-0.91.01.11.01.01.0-1.0
Time in novel zone, hab. session 10.30.32.11.4-0.90.2-0.2-0.2-0.20.2-0.3-0.3-0.0-1.00.10.10.0-0.0
Total zone transitions, hab. session 10.50.71.0-0.60.51.0-1.0-1.0-1.01.0-0.9-0.90.70.50.90.90.8-0.9
Total locomotion distance, hab. session 10.20.21.41.0-1.00.1-0.1-0.1-0.10.10.10.1-0.0-1.20.20.20.1-0.2
Locomotion velocity, hab. session 10.00.10.40.3-0.60.1-0.1-0.1-0.10.10.10.1-0.1-0.40.20.20.1-0.2
Time in familiar zone, hab. session 21.31.31.6-1.11.11.1-1.2-1.2-1.21.2-1.1-1.11.11.11.31.31.2-1.3
Time in novel zone, hab. session 20.00.00.10.20.20.2-0.2-0.1-0.10.1-0.3-0.30.3-0.10.10.10.2-0.1
Total zone transitions, hab. session 20.91.21.5-1.00.91.2-1.2-1.2-1.21.2-1.1-1.10.81.01.11.11.0-1.1
Total locomotion distance, hab. session 20.40.60.9-0.30.50.8-0.8-0.8-0.80.8-0.6-0.60.70.50.90.90.8-0.9
Locomotion velocity, hab. session 20.30.30.60.10.30.7-0.7-0.7-0.70.7-0.4-0.40.50.20.70.70.7-0.7
Novel to familiar place preference ratio3.73.810.32.9-2.4-1.71.71.71.7-1.71.41.4-1.3-3.2-1.8-1.8-1.61.8
Novelty place preference3.73.710.22.9-2.3-1.71.71.71.7-1.71.41.4-1.2-3.2-1.8-1.8-1.61.8
Time in novel zone, NPP test2.93.08.82.7-2.1-1.51.51.51.5-1.51.21.2-1.1-3.0-1.6-1.6-1.41.6
Total zone transitions, NPP test2.94.16.5-2.52.51.9-2.0-1.9-1.91.9-1.7-1.71.62.52.02.01.8-2.0
Total locomotion distance, NPP test0.71.01.5-0.10.11.2-1.2-1.2-1.21.2-0.9-0.90.90.01.21.21.1-1.2
Locomotion velocity, NPP test0.30.40.60.3-0.30.8-0.8-0.8-0.80.8-0.4-0.40.4-0.30.80.80.7-0.8
Intraocular pressure0.00.10.40.2-0.60.1-0.2-0.2-0.20.20.00.00.1-0.30.20.20.2-0.2
Delta distance traveled before/after self-admin0.20.31.4-1.20.1-0.50.50.50.5-0.50.50.5-0.60.0-0.3-0.3-0.40.3
Delta ambulatory time before/after self-admin0.50.60.8-0.1-0.3-0.80.90.80.8-0.80.80.8-0.8-0.5-0.8-0.8-0.90.8
Parametrial fat weight0.10.11.31.1-0.30.1-0.1-0.1-0.10.1-0.2-0.20.3-0.3-0.0-0.00.10.0
Pavlov. Cond. lever latency0.20.30.9-0.31.00.4-0.4-0.4-0.40.4-0.5-0.50.60.80.40.40.5-0.4
Pavlov. Cond. magazine entry latency0.70.91.2-0.1-0.61.1-1.1-1.1-1.11.1-1.0-1.01.0-0.21.11.11.1-1.1
Pavlov. Cond. change in total contacts0.00.00.10.1-0.30.2-0.2-0.2-0.20.2-0.2-0.20.0-0.40.10.10.1-0.1
Pavlov. Cond. index score0.30.40.6-0.3-0.30.7-0.7-0.7-0.70.7-0.7-0.70.6-0.10.70.70.7-0.7
Pavlov. Cond. latency score0.10.11.00.4-1.00.2-0.2-0.2-0.20.2-0.1-0.10.1-0.80.10.10.1-0.1
Pavlov. Cond. lever contacts0.00.00.1-0.1-0.00.1-0.1-0.1-0.10.10.00.0-0.3-0.30.00.0-0.10.0
Pavlov. Cond. magazine entry number0.60.71.00.11.0-0.90.90.90.9-0.90.90.9-0.90.3-0.9-0.9-0.90.9
Pavlov. Cond. intertrial magazine entries3.64.410.5-2.53.21.7-1.8-1.7-1.71.7-1.8-1.81.72.82.12.12.0-2.1
Pavlov. Cond. lever-magazine prob. diff.0.81.01.4-0.6-0.01.2-1.2-1.2-1.21.2-1.1-1.11.00.31.11.11.1-1.1
Pavlov. Cond. response bias0.81.01.4-0.70.11.2-1.2-1.2-1.21.2-1.1-1.10.80.41.21.21.0-1.2
Pavlov. Cond. lever latency0.10.10.40.5-0.6-0.10.10.10.1-0.10.10.1-0.3-0.60.00.0-0.1-0.0
Pavlov. Cond. magazine entry latency0.50.62.6-1.11.60.5-0.5-0.5-0.50.5-0.4-0.40.31.40.60.60.5-0.6
Pavlov. Cond. change in total contacts0.30.40.7-0.1-0.0-0.70.70.70.7-0.70.80.8-0.5-0.1-0.8-0.8-0.70.8
Pavlov. Cond. index score0.10.10.1-0.10.4-0.30.30.30.3-0.30.30.3-0.30.3-0.3-0.3-0.30.3
Pavlov. Cond. latency score0.30.30.50.10.2-0.70.70.70.7-0.70.70.7-0.60.0-0.6-0.6-0.60.6
Pavlov. Cond. lever contacts0.00.00.3-0.30.5-0.10.10.10.1-0.10.10.10.00.3-0.2-0.2-0.10.2
Pavlov. Cond. magazine entry number0.10.20.40.3-0.3-0.40.40.40.4-0.40.40.4-0.2-0.7-0.4-0.4-0.30.4
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.4-0.10.2-0.2-0.2-0.20.2-0.3-0.30.30.30.20.20.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.20.4-0.30.30.30.3-0.30.30.3-0.20.3-0.3-0.2-0.20.2
Pavlov. Cond. response bias0.10.10.7-0.60.90.1-0.1-0.1-0.10.1-0.1-0.10.20.80.00.00.1-0.0
Time in closed arm before self-admin0.40.42.5-1.20.40.0-0.0-0.0-0.00.0-0.0-0.0-1.61.50.20.2-0.5-0.1
Time in closed arm after self-admin0.10.10.7-0.1-0.3-0.40.40.40.4-0.40.40.4-0.80.1-0.2-0.2-0.50.3
Time in open arm before self-admin1.61.86.02.3-1.5-1.11.11.11.1-1.11.11.10.5-2.4-1.3-1.3-0.51.1
Time in open arm after self-admin0.20.21.0-1.00.1-0.50.50.50.5-0.50.50.5-0.1-0.3-0.3-0.4-0.30.3
Bone: periosteal estimation2.04.14.91.6-2.2-2.12.12.12.1-2.12.02.0-2.0-1.8-2.1-2.1-2.02.1
Bone: periosteal perimeter2.74.46.21.6-2.5-2.12.22.12.1-2.12.12.1-2.0-1.9-2.1-2.1-2.12.1
Bone: post-yield work1.62.22.41.2-1.6-1.51.51.51.5-1.51.51.5-1.5-1.3-1.6-1.6-1.51.6
Progressive ratio test 1 active lever presses4.44.67.20.91.32.5-2.5-2.4-2.42.4-2.4-2.42.71.01.91.92.2-1.9
Progressive ratio test 1 breakpoint3.73.96.10.91.22.3-2.3-2.2-2.22.2-2.2-2.22.50.91.71.72.0-1.7
Progressive ratio test 1 inactive lever presses0.80.91.30.01.01.0-1.0-1.0-1.01.0-1.0-1.01.21.01.01.01.0-1.0
Progressive ratio test 2 active lever presses2.42.64.11.11.02.0-1.9-2.0-2.02.0-2.0-2.01.90.71.11.11.4-1.1
Progressive ratio test 2 breakpoint1.82.03.10.11.21.8-1.7-1.7-1.71.7-1.7-1.71.61.01.01.01.2-1.0
Progressive ratio test 2 inactive lever presses0.20.21.71.30.20.4-0.4-0.4-0.40.4-0.4-0.40.40.1-0.0-0.10.10.0
Incentive Sensitization - Responses0.60.60.9-0.60.80.9-0.9-0.9-0.90.9-0.9-0.90.90.70.60.60.6-0.6
Incentive Sensitization - Breakpoint0.70.71.0-0.70.81.0-0.9-1.0-1.01.0-1.0-1.00.90.80.70.60.7-0.6
Sum of active levers in priming session hrs 5-62.82.73.60.91.11.9-1.9-1.9-1.91.9-1.9-1.91.81.01.51.51.6-1.5
Progressive ratio0.10.10.30.4-0.3-0.30.30.30.3-0.30.40.40.2-0.6-0.3-0.3-0.10.3
Food seeking constrained by brief footshock1.72.13.6-1.11.11.4-1.4-1.4-1.41.4-1.6-1.61.90.91.41.41.6-1.4
Seeking ratio, punishment vs. effort0.60.80.9-0.70.71.0-1.0-1.0-1.01.0-0.9-0.90.80.80.90.90.9-0.9
Retroperitoneal fat weight2.16.78.72.9-2.9-2.62.52.62.6-2.62.42.4-2.6-2.6-2.5-2.5-2.62.5
Reaction time number correct1.82.65.8-2.41.71.6-1.5-1.6-1.61.6-1.6-1.60.92.01.61.61.3-1.5
Reaction time mean minus median0.81.02.20.5-1.5-1.01.01.01.0-1.00.90.9-0.8-1.2-1.1-1.1-1.01.1
Reaction time mean minus median AUC1.31.62.0-0.1-1.1-1.41.41.41.4-1.41.31.3-1.4-0.8-1.4-1.4-1.41.4
Reaction time num false alarms1.62.28.8-3.01.71.1-1.1-1.1-1.11.1-1.1-1.10.52.41.31.31.0-1.3
Reaction time num false alarms AUC1.72.47.0-2.71.91.3-1.3-1.3-1.31.3-1.3-1.30.62.51.41.41.1-1.4
Reaction time trials correct on left1.82.65.8-2.41.71.6-1.5-1.6-1.61.6-1.6-1.60.92.01.61.61.3-1.5
Reaction time trials on left1.82.65.7-2.41.61.6-1.5-1.6-1.61.6-1.6-1.60.92.01.51.51.3-1.5
Reaction time mean0.71.01.30.7-1.2-1.11.11.11.1-1.10.90.9-0.7-0.7-1.2-1.2-1.01.1
Reaction time mean AUC1.01.41.80.7-1.0-1.31.31.31.3-1.31.11.1-1.0-0.6-1.4-1.4-1.21.3
Median of all reaction times0.30.40.60.4-0.6-0.70.70.70.7-0.70.60.6-0.2-0.2-0.8-0.8-0.50.7
Reaction time omissions0.40.61.91.4-1.2-0.60.60.60.6-0.60.50.5-0.7-0.9-0.7-0.7-0.70.7
Reaction time false alarm rate0.10.21.0-0.90.6-0.10.00.10.1-0.10.10.1-0.31.00.10.1-0.1-0.1
Reaction time premature initiation rate1.41.94.0-0.20.61.5-1.5-1.5-1.51.5-1.4-1.42.0-0.31.41.41.7-1.4
Reaction time premature initiations2.83.95.6-1.21.12.2-2.2-2.2-2.22.2-2.1-2.12.40.32.12.12.2-2.1
Std. dev. reaction times0.81.22.41.0-1.5-1.01.11.01.0-1.01.01.0-0.9-1.2-1.2-1.2-1.01.1
Reaction time trials completed1.82.65.7-2.41.61.6-1.5-1.6-1.61.6-1.6-1.60.92.01.51.51.3-1.5
Reaction time trials AUC2.33.36.0-2.41.81.8-1.8-1.8-1.81.8-1.8-1.81.22.01.81.81.5-1.7
Run reversals in cocaine runway, females0.40.41.6-0.2-0.1-0.60.60.60.6-0.60.10.1-1.30.4-0.5-0.5-0.90.6
Run reversals in cocaine runway, males0.50.51.20.5-0.5-0.70.70.70.7-0.71.11.1-1.0-0.2-0.5-0.5-0.70.5
Latency to leave start box in cocaine runway0.60.63.6-1.90.70.6-0.6-0.6-0.60.6-0.5-0.50.40.80.80.80.6-0.7
Latency to leave start box in cocaine runway, F0.30.33.6-1.90.40.1-0.1-0.1-0.10.1-0.0-0.0-0.20.60.40.40.1-0.3
Latency to leave start box in cocaine runway, M1.41.41.6-1.11.01.2-1.2-1.2-1.21.2-1.2-1.20.91.31.21.21.1-1.2
Std. dev. time between licks in bursts0.50.61.0-0.20.6-0.80.80.80.8-0.81.01.0-0.8-0.0-0.9-0.9-0.80.9
Total sessions with >9 infusions2.52.84.00.70.92.0-2.0-1.9-1.91.9-1.9-1.92.00.71.41.41.6-1.4
Short access day 1 total inactive lever presses1.82.02.7-0.61.21.3-1.4-1.4-1.41.4-1.4-1.41.61.31.61.61.6-1.6
Short access day 10 total inactive lever presses0.91.01.6-0.4-0.4-1.21.11.11.1-1.11.11.1-1.3-0.2-0.9-0.9-1.11.0
Short access day 1 total infusions2.32.54.52.00.62.1-2.0-2.0-2.02.0-2.0-2.01.40.40.80.80.9-0.8
Short access day 10 total infusions1.82.03.21.80.61.7-1.6-1.7-1.71.7-1.7-1.71.70.40.90.91.2-1.0
Short access total infusions3.64.16.51.51.12.5-2.5-2.5-2.52.5-2.5-2.52.10.91.51.51.7-1.5
Short access day 1 locomotion0.30.30.50.60.60.7-0.6-0.6-0.60.6-0.6-0.60.30.70.40.30.3-0.3
Short access day 10 total locomotion1.01.11.80.60.71.3-1.2-1.3-1.31.3-1.3-1.31.30.50.70.70.9-0.7
Short access total locomotion1.71.82.81.50.71.6-1.5-1.6-1.61.6-1.6-1.61.70.40.90.91.2-0.9
One hour access (0.3 mA shock)1.41.62.61.40.71.6-1.6-1.6-1.61.6-1.6-1.61.50.40.70.70.9-0.7
Compulsive drug intake0.60.61.11.1-0.8-0.90.80.90.9-0.90.90.9-0.3-1.0-0.6-0.6-0.40.6
One hour access (shock baseline)1.82.03.61.10.81.9-1.8-1.8-1.81.8-1.8-1.81.30.70.90.91.0-0.9
Social response proportion0.80.81.30.60.4-0.90.90.90.9-0.90.90.9-0.8-0.3-1.2-1.2-1.01.1
Social responses0.40.52.3-1.11.50.5-0.5-0.5-0.50.5-0.5-0.50.60.80.50.40.5-0.5
Social time0.60.71.3-1.10.1-0.90.90.90.9-0.90.90.9-1.10.5-0.8-0.8-0.90.8
Soleus weight0.41.23.0-1.71.50.9-1.0-1.0-1.01.0-0.9-0.90.81.51.01.00.9-1.0
Bone: stiffness8.914.128.14.8-5.3-3.43.43.43.4-3.43.33.3-3.4-4.5-3.5-3.5-3.53.5
Tibialis anterior weight0.10.40.8-0.1-0.5-0.80.70.70.7-0.70.80.8-0.9-0.1-0.6-0.6-0.70.6
Time to tail flick, vehicle, before self-admin0.20.21.2-0.60.6-0.00.00.00.0-0.00.00.0-0.91.1-0.0-0.0-0.40.1
Time to tail flick, vehicle, after self-admin0.20.22.51.6-0.50.3-0.3-0.3-0.30.3-0.3-0.30.0-0.20.10.10.1-0.1
Time to tail flick, test, before self-admin0.90.93.1-1.80.60.8-0.7-0.8-0.80.8-0.8-0.8-0.61.71.01.00.4-0.9
Time to tail flick, test, after self-admin0.20.20.50.20.30.6-0.6-0.5-0.50.5-0.5-0.5-0.00.70.50.50.3-0.5
Delta time to tail flick, vehicle, before/after SA0.80.77.92.8-1.1-0.10.10.10.1-0.10.10.10.1-1.1-0.5-0.5-0.30.5
Delta time to tail flick, test, before/after SA0.50.42.61.6-0.3-0.50.50.50.5-0.50.50.50.0-0.8-0.7-0.7-0.40.7
Tibia length0.10.32.30.6-1.5-0.30.30.30.3-0.30.30.3-0.1-0.7-0.4-0.4-0.30.4
Ambulatory time before self-admin0.10.11.01.0-0.50.1-0.1-0.1-0.10.10.10.1-0.2-0.20.00.0-0.0-0.0
Ambulatory time after self-admin0.50.51.90.2-0.5-0.70.70.70.7-0.70.70.7-1.4-0.1-0.7-0.7-1.00.7
Bone: tissue strength0.30.30.8-0.20.7-0.50.50.50.5-0.50.60.6-0.50.9-0.6-0.6-0.60.6
Total heroin consumption1.92.23.30.80.71.7-1.7-1.7-1.71.7-1.6-1.61.80.81.41.41.6-1.4
Bone: trabecular number0.71.16.32.3-2.50.4-0.4-0.4-0.40.4-0.3-0.30.1-1.90.10.10.1-0.1
Bone: trabecular spacing0.30.42.6-1.61.3-0.30.30.30.3-0.30.20.2-0.10.8-0.1-0.1-0.10.1
Bone: trabecular thickness0.60.85.51.2-2.30.6-0.6-0.6-0.60.6-0.6-0.60.4-1.10.40.40.4-0.4
Bone: trabecular tissue density0.00.10.6-0.8-0.40.1-0.1-0.1-0.10.1-0.1-0.1-0.00.3-0.1-0.1-0.10.1
Water consumed over 24 hours2.83.47.6-2.12.81.6-1.7-1.6-1.61.6-1.6-1.61.82.21.81.81.8-1.8
Number of responses in last shaping day1.01.15.42.3-0.9-0.90.90.90.9-0.90.90.9-0.6-1.1-0.9-0.9-0.80.9