Hub : Genes

Tle6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Tle6	0.04	0.03	1.3e-03	0.03	0.02	0.02	0.02	2.2e-03	2.6e-03	2.8e-03	5.0e-03
2	Liver	gene expression	Tle6	0.02	0.02	4.2e-03	0	0	0.01	0	8.3e-02	8.4e-02	4.6e-02	1.1e-01
3	NAcc	gene expression	Tle6	0.05	0.04	7.7e-05	0.04	0.03	0.04	0.03	5.2e-05	9.2e-05	1.8e-05	7.2e-05
4	BLA	gene expression	Tle6	0.09	0.07	6.3e-03	0.02	0.04	0.04	0.03	2.3e-02	4.7e-03	5.5e-03	9.4e-03
5	PL	gene expression	Tle6	0.04	0.03	3.1e-03	0.02	0.02	0.02	0.01	3.4e-03	2.2e-03	5.3e-03	8.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.5	2.6	6.9	-1.2	0.1	-0.2	2.1	2.6
Area under the delay curve	1.8	1.9	2.7	1.2	-1.6	-1.6	1.4	1.0
BMI with tail	4.6	15.0	22.5	4.6	-4.7	-4.7	2.8	1.1
BMI without tail	1.8	3.7	7.7	2.4	-2.1	-2.8	0.7	-0.1
Body weight	0.8	3.4	5.8	2.4	-2.4	-2.0	1.2	0.4
Weight adjusted by age	0.5	0.6	1.9	0.8	-0.4	-1.4	-0.2	-0.6
Bone surface	3.0	5.2	13.4	-2.2	0.7	0.3	2.7	3.7
Bone volume	3.1	5.2	13.3	-2.2	0.7	0.3	2.7	3.7
Breakpoint value in progressive ratio session	3.9	4.3	6.8	-1.9	2.6	2.1	-2.1	-1.4
Number of licking bursts	0.5	0.6	1.5	0.8	-0.2	0.2	-0.9	-1.2
Context. condit. distance diff. score	0.2	0.3	0.5	0.7	-0.6	-0.7	0.3	0.0
Locomotion velocity, session 1	0.7	0.8	1.8	-1.3	0.8	0.5	0.5	1.0
Locomotion distance, session 1	0.8	1.1	2.7	-1.0	0.2	0.1	1.2	1.7
Locomotion velocity, session 2	2.6	3.1	7.1	-2.7	2.0	1.7	0.1	1.2
Locomotion distance, session 2	1.5	2.1	4.6	-2.1	1.3	1.2	0.6	1.5
Locomotion velocity, session 3	4.4	5.1	7.7	-2.5	2.8	2.6	-1.9	-1.0
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	0.2	0.0	-0.3	-0.3
Stereotopy head waving bouts, day 3	2.9	3.5	6.3	-2.5	2.4	2.1	-1.0	-0.1
Stereotopy head waving duration, day 3	3.6	4.3	6.9	-2.6	2.6	2.4	-1.3	-0.4
Locomotion velocity, session 7	0.6	0.6	1.2	-1.1	0.9	1.0	-0.2	0.2
Locomotion distance, session 7	0.2	0.3	0.6	0.5	-0.2	0.1	-0.6	-0.8
Stereotopy head waving bouts, day 7	0.6	0.7	1.9	-0.5	0.0	-0.3	1.1	1.4
Stereotopy head waving duration, day 7	0.7	0.8	2.1	-0.9	0.3	0.0	1.0	1.4
Locomotion velocity, session 8	1.1	1.3	2.9	-1.4	0.6	0.2	1.1	1.7
Locomotion distance, session 8	0.1	0.2	0.3	-0.6	0.3	0.3	0.3	0.5
Degree of sensitization distance	0.3	0.3	0.5	0.6	-0.7	-0.5	0.5	0.3
Degree of sensitization stereotypy	2.0	2.2	3.2	0.9	-1.4	-1.6	1.8	1.5
Conditioned locomotion	1.5	1.7	3.8	2.0	-1.5	-1.1	-0.3	-1.0
Cocaine response after cond. corrected	3.6	4.0	8.6	2.9	-2.5	-2.1	0.4	-0.7
Cocaine response after cond. not corrected	3.9	4.3	9.4	3.1	-2.6	-2.2	0.3	-0.9
Cocaine response before conditioning	0.3	0.4	0.9	-0.9	0.8	0.6	-0.1	0.2
Saline control response	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.2	-0.3
Bone: connectivity density	1.1	1.8	4.7	-0.6	-0.3	-0.5	1.9	2.2
Bone: cortical apparent density	0.8	1.1	1.9	1.3	-1.2	-1.4	0.8	0.3
Bone: cortical area	1.1	1.7	3.3	0.2	-0.8	-1.1	1.8	1.8
Bone: cortical porosity	0.4	0.4	1.0	-1.0	0.8	0.5	0.0	0.4
Bone: cortical porosity	0.4	0.5	1.2	-0.6	0.2	-0.1	0.8	1.1
Bone: cortical thickness	1.1	1.8	2.3	1.0	-1.4	-1.5	1.5	1.2
Bone: cortical thickness	0.2	0.3	0.7	0.3	0.0	0.2	-0.7	-0.8
Bone: cortical tissue density	0.6	0.8	1.4	1.1	-1.0	-1.2	0.6	0.2
Condit. Reinf. active minus inactive responses	2.9	3.3	4.9	-2.2	2.2	2.2	-1.3	-0.5
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.8	-1.2	1.6	1.7	-1.5	-1.1
Condit. Reinf. active responses	2.4	2.9	5.8	-2.4	2.1	2.0	-0.6	0.3
Condit. Reinf. inactive responses	0.8	1.0	2.1	-1.5	0.9	0.7	0.5	1.1
Incentive salience index mean	1.5	1.8	3.7	-1.9	1.6	1.5	-0.3	0.4
Condit. Reinf. lever presses	1.0	1.3	3.6	-0.9	0.1	-0.2	1.5	1.9
Condit. Reinf. active minus inactive responses	2.3	2.8	3.7	-1.2	1.8	1.9	-1.9	-1.5
Condit. Reinf. active-inactive response ratio	1.1	1.1	3.0	0.4	0.3	0.5	-1.5	-1.7
Condit. Reinf. active responses	1.9	2.6	4.1	-1.7	1.9	2.0	-1.3	-0.7
Condit. Reinf. inactive responses	1.0	1.2	2.4	-1.6	1.3	1.4	-0.3	0.3
Condit. Reinf. lever presses	2.1	2.9	3.8	-1.4	1.9	1.9	-1.8	-1.3
Condit. Reinf. lever reinforcers received	1.6	2.2	3.3	-1.4	1.6	1.8	-1.5	-1.0
Conditioned reinforcement - actives	1.8	1.8	3.5	-1.7	1.9	1.2	-0.9	-0.2
Conditioned reinforcement - inactives	0.7	0.8	1.9	1.4	-1.0	-0.2	-0.3	-0.9
Conditioned locomotion	6.0	7.3	11.0	-3.0	3.3	3.2	-2.2	-1.1
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.4	-0.7	0.1	0.5	0.3
Patch foraging indifference point AUC	0.7	0.8	1.6	-1.1	1.3	0.6	-0.9	-0.5
Delay disc. indifference point, 0s delay	7.6	8.3	10.8	2.0	-3.0	-3.2	3.3	2.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	-0.4	-0.4	0.4	0.3
Delay disc. indifference point, 2s delay	5.3	5.8	8.3	2.0	-2.7	-2.9	2.5	1.8
Delay disc. indifference point, 24s delay	0.5	0.5	1.2	0.6	-0.7	-1.1	0.5	0.3
Delay disc. indifference point, 4s delay	1.5	1.6	2.5	0.5	-1.1	-1.4	1.6	1.5
Delay disc. indifference point, 8s delay	0.6	0.6	1.5	1.2	-1.1	-0.5	0.2	-0.2
Indifference point function ln k	0.2	0.2	0.5	0.7	-0.7	-0.2	0.3	0.0
Indifference point function log k	0.2	0.2	0.5	0.7	-0.7	-0.2	0.3	0.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.5	-0.6	0.2	0.3	0.2
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	0.8	-0.6	-0.6	-0.3	-0.6
Patch foraging total patch changes 18 sec	0.7	0.9	1.5	-1.0	1.2	1.1	-0.8	-0.4
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	-0.5	0.4	-0.0	-0.0	0.1
Patch foraging total patch changes 6 sec	0.3	0.4	1.5	-0.5	0.3	1.2	-0.3	-0.2
Patch foraging time to switch 0 sec	1.6	2.5	3.8	1.0	-1.7	-1.4	1.9	1.6
Patch foraging water rate 0 sec	0.6	0.9	2.4	0.3	0.2	0.4	-1.3	-1.5
Patch foraging water rate 12 sec	0.9	1.4	3.3	1.8	-1.2	-1.0	-0.5	-1.2
Patch foraging water rate 18 sec	2.0	2.7	7.1	0.7	0.3	0.8	-2.3	-2.7
Patch foraging water rate 24 sec	2.3	3.2	8.1	1.8	-0.7	0.4	-2.0	-2.8
Patch foraging water rate 6 sec	1.4	2.1	4.4	0.1	0.7	1.2	-2.0	-2.1
Seeking ratio, delayed vs. immediate footshock	3.7	4.3	7.5	-2.7	2.5	2.5	-1.1	-0.1
Distance traveled before self-admin	0.3	0.3	0.5	0.1	-0.5	-0.7	0.7	0.6
Distance traveled after self-admin	0.7	0.8	1.6	-1.3	1.0	1.1	-0.5	-0.0
Extensor digitorum longus weight	2.9	11.5	22.4	4.7	-4.3	-3.8	1.5	-0.3
Bone: elastic displacement	0.2	0.2	0.4	-0.6	0.6	0.5	-0.3	-0.0
Bone: elastic work	0.3	0.3	0.6	0.2	-0.4	-0.5	0.8	0.8
Bone: endosteal estimation	0.3	0.7	1.2	0.3	-0.6	-0.8	1.1	1.1
Bone: endosteal perimeter	0.4	0.7	1.3	-1.2	0.8	0.4	0.6	1.1
Epididymis fat weight	0.2	0.5	1.0	-0.3	0.7	0.5	-1.0	-0.9
Delta time in closed arm before/after self-admin	1.5	1.5	3.3	1.4	-0.7	-0.3	-1.2	-1.8
Delta time in open arm before/after self-admin	1.0	1.0	1.5	1.0	-1.2	-1.1	1.0	0.6
Diff in mean of infusions in LGA sessions	1.1	1.2	1.9	-1.2	1.4	1.2	-1.0	-0.5
Delay discount exponential model param	1.6	1.7	2.3	-1.2	1.5	1.5	-1.3	-0.9
Extinction: sum of active levers before priming	1.6	1.6	2.8	-0.6	1.2	1.0	-1.7	-1.5
Active lever presses in extinction session 6	2.0	1.9	3.7	-1.8	1.9	1.3	-1.0	-0.3
Bone: final force	1.4	2.2	3.8	0.7	-1.3	-1.4	1.9	1.8
Bone: final moment	1.1	1.9	3.3	0.6	-1.2	-1.3	1.8	1.6
Food consumed during 24 hour testing period	0.3	0.4	0.6	0.8	-0.8	-0.8	0.4	0.2
Glucose	0.8	1.1	1.9	1.3	-1.4	-1.3	0.7	0.2
Heart weight	0.5	0.7	1.2	-0.4	0.7	0.7	-1.1	-1.0
Delay discount hyperbolic model param	2.3	2.5	3.4	-1.4	1.8	1.8	-1.6	-1.1
Intermittent access intake day 1-15 change	5.5	5.4	8.3	-2.2	2.7	2.9	-2.2	-1.4
Intermittent access intake escalation	6.5	6.4	8.7	-1.7	2.5	3.0	-2.9	-2.4
Intermittent access intake escalation 2	7.4	7.3	9.5	-2.1	2.9	3.1	-3.0	-2.4
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.4	-0.3	0.6	1.0	-1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.8	-0.2	0.6	0.9	-0.9	-0.9
Intermitt. access escalation Index	1.3	1.1	2.4	-0.2	-0.2	-1.0	1.4	1.6
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.3	-0.2	-0.6	0.4	0.3
Intermittent access day 15 total infusions	1.6	1.8	2.3	-0.9	1.5	1.4	-1.5	-1.3
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.7	-1.0	1.3	0.6	-0.8	-0.4
Intermittent access total infusions	0.2	0.2	0.3	-0.1	0.5	0.3	-0.5	-0.5
Intermittent access day 1 locomotion	0.2	0.3	0.4	-0.2	0.5	0.5	-0.6	-0.6
Intermittent access day 15 total locomotion	2.8	3.0	4.2	-1.5	2.0	2.0	-1.7	-1.2
Intermittent access total locomotion	0.7	0.8	1.4	-0.9	1.2	1.0	-0.8	-0.5
Intermittent access standard deviation	2.6	2.7	4.1	-1.5	2.0	1.7	-1.7	-1.2
Left kidney weight	0.2	0.5	1.3	-0.8	0.3	-0.2	0.8	1.1
Right kidney weight	1.0	2.8	4.9	-2.2	2.1	1.9	-0.9	-0.1
Cocaine induced anxiety	0.8	0.9	2.2	-1.5	1.0	0.5	0.4	1.0
Post-drug Anxiety	1.1	1.2	2.4	-1.5	0.8	-0.2	0.9	1.5
Baseline Anxiety	0.1	0.1	0.4	0.2	0.1	0.1	-0.5	-0.6
Tail length	2.6	7.8	11.3	-2.6	3.2	3.4	-2.7	-1.8
Length with tail	1.4	5.2	9.6	-2.6	2.6	3.1	-1.6	-0.6
Length without tail	0.3	0.5	1.0	-0.7	0.1	0.9	0.7	1.0
Times rat made contact with spout	0.2	0.3	0.5	0.7	-0.5	-0.1	-0.4	-0.7
Lifetime Intake	0.0	0.1	0.1	-0.1	0.4	-0.3	-0.1	-0.1
Liver weight, left	1.8	2.9	5.2	2.2	-2.0	-2.3	0.8	0.0
Liver weight, right	1.3	2.2	3.5	1.6	-1.7	-1.9	1.2	0.7
Locomotor activity	2.5	4.0	7.2	-2.6	2.3	2.7	-0.5	0.5
Locomotor testing distance	1.4	2.3	4.0	-2.0	1.9	1.9	-0.6	0.2
Locomotor testing rearing	0.0	0.1	0.1	0.0	0.2	0.0	-0.4	-0.4
Locomotion in novel chamber	0.4	0.5	0.8	-0.9	0.8	0.1	-0.8	-0.6
Locomotion in novel chamber post-restriction	0.4	0.5	1.1	-0.8	1.0	0.7	-0.5	-0.2
Fecal boli incidents, locomotor time 1	1.2	1.3	2.7	1.6	-1.4	-1.3	0.2	-0.5
Change in fecal boli incidents, locomotor task	0.7	0.6	1.4	-1.0	0.5	0.2	0.7	1.2
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.4	0.1	-0.6	-1.0	1.2	1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	0.5	0.3	-0.4	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.6	0.6	0.3	-0.3	-0.1
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.6	0.5	0.1	0.1	0.3
Distance moved, locomotor task time 1	0.7	0.8	1.5	0.2	-0.8	-0.6	1.2	1.2
Vertical activity count, locomotor time 1	0.1	0.1	0.1	0.3	-0.3	0.2	-0.2	-0.3
Time >=10cm from walls, locomotor time 2	0.8	0.9	2.0	1.4	-1.1	-1.0	0.2	-0.3
Bouts of movement, locomotor time 2	0.5	0.5	1.1	-1.1	0.6	0.4	0.5	0.9
Total resting periods, locomotor time 2	0.6	0.6	1.2	-1.1	0.6	0.2	0.6	1.0
Rest time, locomotor task time 2	0.4	0.5	1.4	-1.2	0.8	0.2	0.2	0.6
Distance moved, locomotor task time 2	0.6	0.7	1.9	1.4	-1.0	-0.6	-0.0	-0.5
Vertical activity count, locomotor time 2	0.8	0.9	2.3	1.5	-0.9	-0.4	-0.5	-1.1
Light reinforcement 1	4.5	8.3	16.2	-3.2	3.2	4.0	-1.9	-0.8
Light reinforcement 2	1.4	1.8	3.9	-1.4	1.5	2.0	-0.9	-0.4
Bone: marrow area	0.3	0.7	1.2	0.3	-0.6	-0.8	1.1	1.0
Bone: maximum diameter	0.7	1.3	2.6	-1.6	1.1	0.7	0.7	1.3
Bone: maximum force	1.3	2.2	3.4	0.9	-1.4	-1.6	1.8	1.5
Bone: maximum moment	1.1	1.9	3.0	0.8	-1.3	-1.5	1.7	1.5
Mean time between licks in bursts	3.3	4.7	6.6	-2.0	2.5	2.6	-2.1	-1.4
Mean num. licks in bursts	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.4	0.5
Cd content in liver	0.2	0.2	0.2	0.3	-0.5	-0.5	0.4	0.3
Co content in liver	0.6	0.7	1.1	-0.5	0.8	1.0	-1.0	-0.8
Cu content in liver	0.5	0.6	1.5	-0.2	-0.3	-0.3	1.1	1.2
Fe content in liver	0.1	0.2	0.5	0.2	0.1	0.1	-0.6	-0.7
K content in liver	0.5	0.5	1.3	-0.5	0.0	-0.1	0.9	1.1
Mg content in liver	0.7	0.7	2.0	-0.6	0.1	-0.3	1.1	1.4
Mn content in liver	2.1	2.3	4.6	-2.0	1.1	0.4	1.3	2.2
Na content in liver	1.1	1.1	1.7	0.7	-1.1	-1.1	1.3	1.1
Rb content in liver	1.1	1.3	2.8	-0.0	-0.6	-1.0	1.6	1.7
Se content in liver	0.1	0.1	0.3	-0.5	0.5	0.4	-0.1	0.1
Sr content in liver	0.7	0.6	1.7	0.5	0.1	0.4	-1.1	-1.3
Zn content in liver	3.1	3.4	6.0	-0.6	1.5	1.8	-2.5	-2.3
Bone: minimum diameter	0.3	0.5	1.4	-0.4	-0.0	-0.3	1.0	1.2
Time in familiar zone, hab. session 1	1.8	1.7	2.4	-1.2	1.5	1.5	-1.3	-0.9
Time in novel zone, hab. session 1	1.6	1.5	2.6	0.5	-1.0	-1.2	1.6	1.5
Total zone transitions, hab. session 1	0.8	1.2	2.7	-1.6	1.0	0.8	0.4	1.1
Total locomotion distance, hab. session 1	1.6	2.2	4.4	-2.1	1.1	0.7	1.1	2.0
Locomotion velocity, hab. session 1	1.4	2.0	4.6	-2.1	1.4	1.1	0.5	1.4
Time in familiar zone, hab. session 2	5.6	5.8	7.7	-2.1	2.7	2.8	-2.5	-1.8
Time in novel zone, hab. session 2	4.6	4.6	5.9	1.6	-2.3	-2.4	2.4	1.9
Total zone transitions, hab. session 2	1.2	1.5	3.7	-0.4	-0.6	-0.6	1.7	1.9
Total locomotion distance, hab. session 2	0.8	1.1	2.5	-1.6	0.9	1.0	0.3	1.0
Locomotion velocity, hab. session 2	0.9	1.3	2.8	-1.7	0.9	0.9	0.6	1.3
Novel to familiar place preference ratio	4.3	4.4	6.1	1.3	-2.0	-2.4	2.5	2.1
Novelty place preference	2.8	2.9	4.3	0.9	-1.5	-1.9	2.1	1.8
Time in novel zone, NPP test	3.0	3.0	4.3	1.0	-1.7	-2.0	2.1	1.8
Total zone transitions, NPP test	0.2	0.3	0.9	-0.3	-0.2	-0.1	0.8	0.9
Total locomotion distance, NPP test	0.5	0.7	1.9	-0.5	-0.2	-0.3	1.1	1.4
Locomotion velocity, NPP test	0.4	0.6	1.5	-0.7	0.1	0.0	0.9	1.2
Intraocular pressure	0.6	0.8	2.3	0.2	0.3	0.2	-1.3	-1.5
Delta distance traveled before/after self-admin	1.3	1.4	2.6	-1.3	1.3	1.6	-0.8	-0.4
Delta ambulatory time before/after self-admin	1.1	1.3	2.6	-1.6	1.4	1.2	-0.5	0.1
Parametrial fat weight	0.4	0.8	1.0	-0.7	1.0	1.0	-1.0	-0.8
Pavlov. Cond. lever latency	0.5	0.6	1.7	0.5	0.1	0.3	-1.1	-1.3
Pavlov. Cond. magazine entry latency	2.0	2.6	3.7	-1.7	1.9	1.9	-1.5	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.2	0.3	-0.1	0.1
Pavlov. Cond. index score	0.3	0.4	0.9	-1.0	0.6	0.5	0.2	0.6
Pavlov. Cond. latency score	0.5	0.6	1.2	-1.1	0.6	0.4	0.5	1.0
Pavlov. Cond. lever contacts	0.7	0.8	2.2	-0.8	0.2	-0.1	1.1	1.5
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	0.8	-0.9	-0.8	0.5	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	0.1	0.3	0.5	-0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	-1.2	0.9	0.8	-0.0	0.5
Pavlov. Cond. response bias	0.7	0.8	1.3	-1.1	1.1	1.1	-0.6	-0.2
Pavlov. Cond. lever latency	0.6	0.9	1.4	1.2	-1.2	-1.0	0.6	0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.9	0.9	0.5	-0.1	0.2
Pavlov. Cond. change in total contacts	0.7	1.0	1.5	-1.1	1.2	1.0	-0.9	-0.5
Pavlov. Cond. index score	0.7	0.9	1.6	-1.1	1.3	1.0	-0.7	-0.3
Pavlov. Cond. latency score	0.6	0.7	1.4	-1.1	1.2	0.9	-0.4	0.0
Pavlov. Cond. lever contacts	0.7	0.9	1.3	-1.0	1.2	1.0	-0.9	-0.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.5	1.2	-1.2	-0.8	0.3	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	1.1	-0.9	-0.1	-0.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.6	-1.2	1.3	1.0	-0.5	-0.1
Pavlov. Cond. response bias	1.5	2.0	3.2	-1.5	1.8	1.6	-1.3	-0.8
Time in closed arm before self-admin	1.1	1.3	2.3	0.5	-1.1	-0.8	1.5	1.4
Time in closed arm after self-admin	0.0	0.1	0.1	-0.2	0.1	0.4	-0.2	-0.2
Time in open arm before self-admin	1.0	1.1	1.4	-0.9	1.2	1.2	-1.1	-0.8
Time in open arm after self-admin	0.5	0.6	1.3	1.2	-0.9	-0.7	0.3	-0.1
Bone: periosteal estimation	0.9	1.8	3.7	0.1	-0.7	-1.1	1.9	1.9
Bone: periosteal perimeter	0.6	1.0	2.5	-0.9	0.3	-0.1	1.2	1.6
Bone: post-yield work	0.5	0.7	1.0	1.0	-1.0	-1.0	0.6	0.3
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.7	-0.4	-0.5	-0.1	-0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	0.7	-0.4	-0.7	0.1	-0.2
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.0	0.1	0.0	0.0	-0.0
Progressive ratio test 2 active lever presses	0.3	0.3	0.5	-0.2	0.6	0.1	-0.7	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.6	0.8	0.0	-0.4	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	0.3	0.0	-0.0	0.1
Incentive Sensitization - Responses	0.4	0.4	0.7	-0.4	0.8	0.2	-0.8	-0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	-0.6	0.9	0.1	-0.7	-0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	0.0	-0.2	-0.2	-0.2
Progressive ratio	0.3	0.3	0.9	0.6	-0.3	-0.9	-0.2	-0.4
Food seeking constrained by brief footshock	0.1	0.2	0.5	-0.4	0.3	0.7	-0.3	-0.1
Seeking ratio, punishment vs. effort	0.3	0.3	1.4	-0.4	0.1	1.2	0.0	0.2
Retroperitoneal fat weight	0.3	1.1	2.8	1.7	-1.4	-0.5	0.2	-0.5
Reaction time number correct	0.6	0.9	1.8	1.4	-0.9	-0.7	-0.5	-1.0
Reaction time mean minus median	0.5	0.7	1.7	-1.3	1.2	0.4	-0.4	0.0
Reaction time mean minus median AUC	0.9	1.2	2.7	-0.9	0.3	-0.8	1.3	1.6
Reaction time num false alarms	0.1	0.1	0.2	0.4	-0.2	-0.1	-0.3	-0.4
Reaction time num false alarms AUC	0.2	0.3	0.5	0.7	-0.2	-0.4	-0.5	-0.7
Reaction time trials correct on left	0.6	0.9	1.8	1.4	-0.9	-0.7	-0.5	-1.0
Reaction time trials on left	0.6	0.8	1.8	1.3	-0.9	-0.7	-0.4	-0.9
Reaction time mean	0.5	0.7	1.7	-0.6	0.1	-0.7	1.0	1.3
Reaction time mean AUC	0.5	0.7	1.6	-0.5	-0.0	-0.7	1.1	1.3
Median of all reaction times	0.8	1.1	2.0	-0.0	-0.5	-1.1	1.4	1.4
Reaction time omissions	0.2	0.2	0.5	-0.7	0.6	0.3	-0.0	0.2
Reaction time false alarm rate	0.0	0.0	0.1	-0.0	0.0	-0.2	0.2	0.2
Reaction time premature initiation rate	1.4	1.8	3.3	-0.6	1.0	1.8	-1.5	-1.4
Reaction time premature initiations	1.6	2.2	4.2	0.1	0.6	1.6	-1.9	-2.1
Std. dev. reaction times	0.3	0.5	1.1	-1.1	0.8	-0.3	0.3	0.7
Reaction time trials completed	0.6	0.8	1.8	1.3	-0.9	-0.7	-0.4	-0.9
Reaction time trials AUC	0.7	0.9	1.9	1.4	-0.9	-0.6	-0.6	-1.2
Run reversals in cocaine runway, females	0.6	0.6	1.7	-1.3	0.7	0.6	0.0	0.5
Run reversals in cocaine runway, males	0.9	0.9	2.0	-1.4	1.2	0.9	-0.2	0.4
Latency to leave start box in cocaine runway	1.0	1.1	2.7	-1.6	1.1	0.4	0.5	1.1
Latency to leave start box in cocaine runway, F	1.6	1.8	4.5	-0.9	0.1	-0.8	1.7	2.1
Latency to leave start box in cocaine runway, M	2.9	2.7	3.9	-1.2	1.8	1.5	-2.0	-1.6
Std. dev. time between licks in bursts	0.7	0.8	1.8	-1.3	0.9	0.9	0.3	0.8
Total sessions with >9 infusions	0.5	0.5	1.0	-0.5	0.3	-0.9	0.8	1.0
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.2	-0.1
Short access day 10 total inactive lever presses	0.3	0.4	0.8	0.2	0.1	0.6	-0.8	-0.9
Short access day 1 total infusions	0.5	0.5	1.0	-0.7	0.5	-0.5	0.7	1.0
Short access day 10 total infusions	0.1	0.2	0.7	0.0	0.3	-0.8	-0.0	0.0
Short access total infusions	0.4	0.5	1.3	-0.3	0.3	-1.1	0.5	0.7
Short access day 1 locomotion	0.5	0.6	1.0	-0.9	0.9	1.0	-0.1	0.2
Short access day 10 total locomotion	3.5	3.9	5.6	-1.7	2.2	2.4	-2.0	-1.4
Short access total locomotion	0.5	0.5	1.3	-1.0	1.1	0.6	-0.4	-0.1
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.7	-0.5	-0.4	0.2	-0.1
Compulsive drug intake	0.6	0.6	1.4	0.7	-1.2	-0.2	0.9	0.7
One hour access (shock baseline)	0.2	0.2	0.6	0.3	0.2	0.1	-0.6	-0.8
Social response proportion	0.4	0.4	1.0	-1.0	0.9	0.3	-0.1	0.3
Social responses	5.0	6.5	12.4	-3.5	3.4	2.6	-1.2	0.2
Social time	0.5	0.7	1.5	1.2	-1.0	-0.8	0.3	-0.1
Soleus weight	6.3	18.4	26.9	5.0	-5.2	-5.2	3.3	1.5
Bone: stiffness	2.5	3.9	5.0	1.7	-2.2	-2.2	2.1	1.5
Tibialis anterior weight	0.6	2.2	3.2	1.7	-1.8	-1.7	1.2	0.6
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.0	-1.4	0.8	0.2	0.6	1.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.1	0.0	0.3	0.2	-1.0	-1.1
Time to tail flick, test, before self-admin	0.9	0.8	1.9	-0.9	0.5	-0.6	0.9	1.4
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.7	0.6	-0.3	0.4	0.7
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	2.0	1.3	-0.7	-0.4	-0.8	-1.4
Delta time to tail flick, test, before/after SA	0.6	0.5	1.2	0.1	0.3	0.7	-1.0	-1.1
Tibia length	0.7	2.0	2.8	-1.3	1.6	1.7	-1.4	-0.9
Ambulatory time before self-admin	0.2	0.2	0.5	0.3	-0.4	-0.7	0.5	0.3
Ambulatory time after self-admin	0.4	0.4	0.9	-1.0	0.8	0.7	-0.3	-0.0
Bone: tissue strength	1.6	1.5	2.2	1.2	-1.3	-1.5	1.2	0.8
Total heroin consumption	1.1	1.3	3.0	-1.6	1.7	0.7	-0.7	-0.1
Bone: trabecular number	1.1	1.6	3.5	-1.9	1.1	1.0	0.7	1.4
Bone: trabecular spacing	1.8	2.3	5.3	1.7	-0.8	-0.4	-1.6	-2.3
Bone: trabecular thickness	3.6	4.3	11.6	-1.6	0.2	-0.3	2.7	3.4
Bone: trabecular tissue density	1.8	2.6	5.6	2.4	-1.8	-1.8	0.3	-0.6
Water consumed over 24 hours	0.9	1.1	1.9	0.3	-0.8	-0.9	1.4	1.3
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.5	0.3	-0.2	-0.0