Hub : Genes

Tle5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr7_8144249_8144373	0.03	0.02	5.1e-03	0	0.01	0.01	0.01	7.4e-02	6.9e-02	1.9e-02	2.8e-02
2	NAcc	intron excision ratio	chr7_8144249_8144373	0.04	0.03	2.1e-05	0.04	0.03	0.04	0.03	1.9e-05	2.1e-04	3.8e-05	1.1e-04
3	PL	isoform ratio	XM_039078585.1	0.03	0.02	4.1e-04	0.03	0.03	0.03	0.03	1.6e-04	2.4e-04	3.5e-04	2.0e-04
4	pVTA	isoform ratio	XM_039078585.1	0.06	0.05	6.7e-03	0.05	0.04	0.04	0.04	2.5e-03	8.1e-03	1.1e-02	6.6e-03
5	pVTA	intron excision ratio	chr7_8144252_8144373	0.07	0.06	6.5e-03	0.06	0.04	0.05	0.05	1.7e-03	7.0e-03	4.3e-03	4.8e-03
6	NAcc	intron excision ratio	chr7_8144252_8144373	0.04	0.03	2.6e-05	0.04	0.03	0.03	0.03	3.0e-05	5.1e-04	1.1e-04	2.8e-04
7	NAcc	isoform ratio	XM_039078585.1	0.03	0.02	6.2e-04	0.01	0.02	0.01	0.01	8.2e-03	4.3e-03	9.9e-03	8.7e-03
8	Brain	mRNA stability	Tle5	0.05	0.04	5.3e-04	0.03	0.02	0.02	0.03	5.4e-04	1.2e-02	3.8e-03	1.9e-03
9	OFC	intron excision ratio	chr7_8145691_8148398	0.12	0.09	5.3e-03	0.04	-0	-0	0.01	5.1e-02	3.6e-01	3.4e-01	2.1e-01
10	BLA	isoform ratio	XM_039078585.1	0.06	0.05	8.5e-03	0.03	0.01	0.02	0.01	1.1e-02	1.3e-01	4.7e-02	6.1e-02
11	Liver	isoform ratio	XM_039078585.1	0.02	0.02	9.7e-03	0.01	0.01	0.02	0.01	3.7e-02	7.0e-02	6.0e-03	1.4e-02
12	Brain	gene expression	Tle5	0.06	0.05	1.8e-03	0.01	0.02	0.02	0.02	3.9e-02	5.2e-03	6.3e-03	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	1.1	1.9	7.0	-1.3	-1.1	-1.1	-1.2	1.1	1.2	0.5	0.6	0.5	0.6	-2.5	-2.6
Area under the delay curve	1.5	1.6	2.6	1.1	1.3	1.3	1.2	-1.2	-1.2	-1.4	1.6	1.6	1.6	0.1	0.0
BMI with tail	6.0	19.4	25.6	5.1	4.7	4.7	4.6	-4.6	-4.6	-4.7	4.6	4.6	4.6	2.8	2.1
BMI without tail	2.7	5.6	10.5	3.2	2.6	2.6	2.5	-2.7	-2.4	-2.3	2.0	2.1	2.0	2.1	1.7
Body weight	1.1	4.4	6.0	2.1	2.2	2.2	2.5	-2.2	-2.3	-2.4	2.2	2.3	2.1	1.1	1.2
Weight adjusted by age	0.6	0.7	2.2	1.5	0.9	0.9	0.8	-1.2	-0.7	-0.7	0.3	0.4	0.3	0.9	1.0
Bone surface	2.9	5.2	16.2	-2.3	-2.2	-2.2	-2.2	2.2	2.2	1.2	0.3	0.3	0.3	-3.8	-4.0
Bone volume	3.0	5.1	16.2	-2.3	-2.2	-2.2	-2.2	2.2	2.2	1.2	0.3	0.2	0.3	-3.8	-4.0
Breakpoint value in progressive ratio session	3.8	4.2	7.1	-1.8	-2.2	-2.2	-1.9	2.0	2.0	2.3	-2.7	-2.5	-2.6	-0.4	-0.2
Number of licking bursts	0.5	0.6	2.0	0.8	0.6	0.6	0.8	-0.6	-0.8	-0.4	-0.0	0.0	-0.0	1.4	1.4
Context. condit. distance diff. score	0.3	0.4	0.5	0.6	0.6	0.6	0.7	-0.6	-0.6	-0.7	0.6	0.7	0.6	0.4	0.4
Locomotion velocity, session 1	1.3	1.4	2.5	-1.3	-1.3	-1.3	-1.3	1.3	1.3	1.0	-0.6	-0.6	-0.6	-1.6	-1.6
Locomotion distance, session 1	0.8	1.0	3.4	-1.0	-0.9	-0.9	-1.0	0.9	0.9	0.6	0.1	0.0	0.1	-1.8	-1.8
Locomotion velocity, session 2	4.9	5.7	7.2	-2.7	-2.6	-2.6	-2.7	2.7	2.6	2.3	-1.6	-1.7	-1.6	-2.6	-2.5
Locomotion distance, session 2	2.6	3.6	5.9	-2.1	-2.0	-2.0	-2.1	2.1	2.0	1.7	-0.9	-1.0	-0.9	-2.4	-2.4
Locomotion velocity, session 3	5.1	5.9	7.6	-2.5	-2.6	-2.6	-2.5	2.5	2.6	2.7	-2.8	-2.8	-2.8	-1.1	-0.9
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	-0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	0.2
Stereotopy head waving bouts, day 3	4.6	5.4	6.4	-2.5	-2.5	-2.5	-2.5	2.5	2.5	2.5	-2.2	-2.2	-2.2	-1.7	-1.5
Stereotopy head waving duration, day 3	5.0	6.0	7.2	-2.6	-2.6	-2.6	-2.6	2.6	2.6	2.7	-2.5	-2.5	-2.5	-1.6	-1.4
Locomotion velocity, session 7	0.9	0.9	1.2	-1.0	-1.0	-1.0	-1.1	1.1	1.0	1.0	-0.8	-0.9	-0.8	-0.9	-0.8
Locomotion distance, session 7	0.2	0.3	0.8	0.6	0.5	0.5	0.5	-0.5	-0.5	-0.3	0.0	0.0	0.0	0.9	0.9
Stereotopy head waving bouts, day 7	0.4	0.5	1.8	-0.6	-0.6	-0.6	-0.5	0.6	0.6	0.2	0.2	0.3	0.2	-1.3	-1.3
Stereotopy head waving duration, day 7	0.8	1.0	2.8	-1.0	-1.0	-1.0	-0.9	1.0	1.0	0.6	-0.1	-0.0	-0.1	-1.6	-1.7
Locomotion velocity, session 8	1.5	1.8	4.4	-1.5	-1.4	-1.4	-1.4	1.4	1.4	0.9	-0.3	-0.2	-0.3	-2.1	-2.1
Locomotion distance, session 8	0.2	0.2	0.5	-0.5	-0.5	-0.5	-0.6	0.5	0.5	0.4	-0.1	-0.2	-0.1	-0.7	-0.7
Degree of sensitization distance	0.3	0.3	0.5	0.6	0.6	0.6	0.6	-0.5	-0.6	-0.6	0.7	0.7	0.7	0.2	0.2
Degree of sensitization stereotypy	1.1	1.2	2.7	0.8	0.9	0.9	0.9	-0.8	-0.9	-1.2	1.6	1.6	1.6	-0.4	-0.6
Conditioned locomotion	2.7	3.2	4.2	2.0	2.0	2.0	2.0	-2.0	-2.0	-1.7	1.1	1.1	1.1	2.0	2.0
Cocaine response after cond. corrected	6.2	6.9	8.8	3.0	2.9	2.9	2.9	-2.9	-3.0	-2.7	2.1	2.1	2.1	2.4	2.4
Cocaine response after cond. not corrected	6.8	7.5	9.6	3.1	3.0	3.0	3.1	-3.0	-3.1	-2.8	2.1	2.1	2.2	2.6	2.5
Cocaine response before conditioning	0.6	0.7	1.0	-1.0	-1.0	-1.0	-0.9	0.9	0.9	0.9	-0.7	-0.7	-0.7	-0.8	-0.8
Saline control response	0.1	0.1	0.3	0.5	0.4	0.4	0.4	-0.4	-0.4	-0.3	0.2	0.1	0.2	0.5	0.5
Bone: connectivity density	0.6	0.9	3.6	-0.6	-0.5	-0.5	-0.6	0.5	0.5	-0.1	0.9	0.8	0.9	-1.7	-1.9
Bone: cortical apparent density	0.9	1.2	1.9	1.1	1.1	1.1	1.3	-1.1	-1.1	-1.3	1.2	1.4	1.2	0.6	0.5
Bone: cortical area	0.4	0.6	1.7	0.1	0.2	0.2	0.2	-0.2	-0.1	-0.7	1.2	1.3	1.2	-1.1	-1.2
Bone: cortical porosity	0.8	0.8	1.1	-1.0	-1.0	-1.0	-1.0	1.0	1.0	0.9	-0.6	-0.6	-0.7	-1.0	-0.9
Bone: cortical porosity	0.4	0.4	1.4	-0.7	-0.6	-0.6	-0.6	0.6	0.6	0.3	0.1	0.1	0.1	-1.1	-1.2
Bone: cortical thickness	0.8	1.3	2.7	0.9	1.0	1.0	1.0	-1.0	-1.0	-1.3	1.6	1.6	1.6	-0.1	-0.2
Bone: cortical thickness	0.1	0.2	0.6	0.4	0.3	0.3	0.3	-0.3	-0.3	-0.1	-0.2	-0.3	-0.2	0.8	0.8
Bone: cortical tissue density	0.7	0.9	1.4	0.9	0.9	0.9	1.1	-0.9	-1.0	-1.1	0.9	1.2	1.0	0.5	0.5
Condit. Reinf. active minus inactive responses	3.5	3.9	5.0	-1.9	-2.1	-2.1	-2.2	2.2	2.1	2.2	-2.1	-2.2	-2.1	-0.6	-1.0
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.8	-1.2	-1.2	-1.2	-1.2	1.3	1.2	1.5	-1.7	-1.7	-1.7	-0.2	0.0
Condit. Reinf. active responses	3.6	4.4	5.9	-2.1	-2.3	-2.3	-2.4	2.4	2.4	2.3	-1.9	-1.9	-1.9	-1.2	-1.8
Condit. Reinf. inactive responses	1.2	1.4	2.9	-1.1	-1.3	-1.3	-1.5	1.4	1.4	1.2	-0.6	-0.7	-0.6	-0.9	-1.7
Incentive salience index mean	2.4	2.9	3.9	-1.8	-1.9	-1.9	-1.9	2.0	1.9	1.8	-1.4	-1.4	-1.4	-1.2	-1.5
Condit. Reinf. lever presses	0.8	1.0	3.9	-0.9	-0.9	-0.9	-0.9	1.0	0.9	0.4	0.3	0.3	0.3	-1.6	-2.0
Condit. Reinf. active minus inactive responses	1.5	1.9	3.8	-1.2	-1.3	-1.3	-1.2	1.2	1.2	1.6	-1.9	-1.9	-1.9	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	2.2	0.5	0.4	0.4	0.4	-0.4	-0.4	0.1	-0.7	-0.7	-0.7	1.4	1.5
Condit. Reinf. active responses	1.9	2.6	3.6	-1.6	-1.7	-1.7	-1.7	1.7	1.7	1.9	-1.8	-1.9	-1.8	-0.6	-0.5
Condit. Reinf. inactive responses	1.5	1.9	2.4	-1.5	-1.6	-1.6	-1.6	1.5	1.5	1.4	-1.0	-1.1	-1.0	-1.2	-1.2
Condit. Reinf. lever presses	1.7	2.3	4.0	-1.4	-1.4	-1.4	-1.4	1.4	1.4	1.8	-2.0	-2.0	-2.0	-0.1	0.1
Condit. Reinf. lever reinforcers received	1.3	1.9	3.2	-1.3	-1.4	-1.4	-1.4	1.3	1.3	1.6	-1.7	-1.8	-1.7	-0.2	-0.2
Conditioned reinforcement - actives	2.2	2.2	3.0	-1.1	-1.5	-1.5	-1.7	1.6	1.7	1.7	-1.7	-1.6	-1.6	0.1	-0.9
Conditioned reinforcement - inactives	1.0	1.1	2.1	0.4	1.2	1.2	1.4	-1.0	-1.4	-1.1	0.6	0.6	0.6	0.9	1.4
Conditioned locomotion	6.8	8.1	10.4	-2.7	-3.1	-3.1	-3.0	3.0	3.0	3.2	-3.2	-3.2	-3.2	-0.8	-1.1
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.0	0.5	0.5	0.4	-0.3	-0.5	-0.5	0.6	0.5	0.6	0.1	-0.0
Patch foraging indifference point AUC	0.8	0.9	1.4	-0.4	-1.0	-1.0	-1.1	0.9	1.1	1.1	-1.2	-1.1	-1.2	-0.4	-0.3
Delay disc. indifference point, 0s delay	4.4	4.8	9.8	1.6	2.0	2.0	2.0	-1.9	-1.9	-2.5	3.1	3.1	3.0	-0.5	-0.8
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.2	0.3	0.3	0.3	-0.3	-0.3	-0.3	0.4	0.4	0.5	-0.0	-0.1
Delay disc. indifference point, 2s delay	3.9	4.3	7.3	1.9	2.1	2.1	2.0	-2.0	-2.0	-2.4	2.7	2.7	2.7	0.1	-0.1
Delay disc. indifference point, 24s delay	0.5	0.5	0.7	0.8	0.7	0.7	0.6	-0.8	-0.8	-0.7	0.7	0.7	0.8	0.4	0.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.7	0.5	0.6	0.6	0.5	-0.6	-0.6	-0.8	1.3	1.2	1.3	-0.6	-0.8
Delay disc. indifference point, 8s delay	1.1	1.1	1.5	1.1	1.2	1.2	1.2	-1.2	-1.1	-1.1	1.0	0.9	0.9	0.9	0.9
Indifference point function ln k	0.2	0.3	0.5	0.2	0.5	0.5	0.7	-0.5	-0.7	-0.7	0.6	0.6	0.6	0.5	0.4
Indifference point function log k	0.2	0.3	0.5	0.2	0.5	0.5	0.7	-0.5	-0.7	-0.7	0.6	0.6	0.6	0.5	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.0	0.5	0.5	0.5	-0.3	-0.5	-0.5	0.5	0.4	0.5	0.3	0.2
Patch foraging total patch changes 12 sec	0.6	0.8	1.7	1.3	1.0	1.0	0.9	-1.1	-1.0	-0.7	0.5	0.4	0.5	1.0	1.0
Patch foraging total patch changes 18 sec	0.7	0.9	1.3	-0.8	-0.9	-0.9	-1.0	1.1	1.1	1.1	-1.2	-1.0	-1.2	-0.5	-0.3
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.1	-0.2	-0.2	-0.4	0.3	0.4	0.4	-0.2	-0.3	-0.2	-0.4	-0.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	-0.9	-0.4	-0.4	-0.4	0.6	0.3	0.4	-0.4	-0.5	-0.4	-0.1	-0.1
Patch foraging time to switch 0 sec	1.0	1.6	3.5	0.6	1.1	1.1	1.1	-1.0	-1.1	-1.4	1.9	1.9	1.9	-0.4	-0.6
Patch foraging water rate 0 sec	0.3	0.5	2.0	0.7	0.3	0.3	0.3	-0.4	-0.5	-0.0	-0.5	-0.7	-0.5	1.3	1.4
Patch foraging water rate 12 sec	1.7	2.5	4.3	2.1	1.6	1.6	1.8	-1.8	-1.7	-1.4	0.8	0.9	0.8	1.9	2.0
Patch foraging water rate 18 sec	1.1	1.5	6.0	1.2	0.8	0.8	0.7	-0.9	-0.8	-0.1	-0.8	-1.0	-0.8	2.3	2.5
Patch foraging water rate 24 sec	2.3	3.1	10.1	1.5	1.6	1.6	1.8	-1.6	-1.9	-1.0	-0.1	-0.2	-0.1	3.1	3.2
Patch foraging water rate 6 sec	0.5	0.7	2.5	0.2	0.0	0.0	0.1	-0.0	-0.1	0.5	-1.1	-1.1	-1.1	1.5	1.6
Seeking ratio, delayed vs. immediate footshock	5.2	5.9	7.5	-2.7	-2.7	-2.7	-2.7	2.7	2.6	2.6	-2.3	-2.4	-2.3	-1.6	-1.6
Distance traveled before self-admin	0.1	0.1	0.3	0.4	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.6	0.5	0.5	-0.2	-0.3
Distance traveled after self-admin	1.1	1.2	1.8	-1.1	-1.3	-1.3	-1.2	1.0	1.1	1.1	-0.9	-1.1	-1.0	-0.7	-0.7
Extensor digitorum longus weight	4.8	18.9	24.8	5.0	4.7	4.7	4.7	-4.6	-4.6	-4.6	3.9	3.9	3.9	4.0	3.1
Bone: elastic displacement	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.6	0.7	0.6	-0.6	-0.5	-0.6	-0.4	-0.3
Bone: elastic work	0.1	0.1	0.4	0.1	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.6	0.6	0.6	-0.4	-0.4
Bone: endosteal estimation	0.1	0.3	0.8	0.2	0.2	0.2	0.3	-0.2	-0.2	-0.5	0.8	0.9	0.8	-0.5	-0.6
Bone: endosteal perimeter	0.6	1.3	2.4	-1.3	-1.2	-1.2	-1.2	1.2	1.3	0.9	-0.4	-0.3	-0.4	-1.6	-1.5
Epididymis fat weight	0.2	0.5	2.7	0.3	-0.4	-0.4	-0.3	0.1	0.3	0.5	-0.8	-0.8	-0.8	1.7	0.5
Delta time in closed arm before/after self-admin	2.4	2.3	5.2	1.8	1.8	1.8	1.5	-1.6	-1.4	-1.0	0.3	0.2	0.2	2.3	2.3
Delta time in open arm before/after self-admin	0.9	0.9	1.5	0.6	0.9	0.9	1.0	-0.9	-1.0	-1.2	1.2	1.2	1.2	0.2	0.2
Diff in mean of infusions in LGA sessions	1.3	1.5	2.1	-1.1	-1.4	-1.4	-1.2	1.2	1.2	1.3	-1.4	-1.3	-1.4	-0.5	-0.4
Delay discount exponential model param	1.3	1.4	2.3	-1.1	-1.2	-1.2	-1.2	1.2	1.2	1.4	-1.5	-1.5	-1.5	-0.2	-0.1
Extinction: sum of active levers before priming	0.8	0.8	2.0	-0.4	-0.5	-0.5	-0.5	0.6	0.5	0.9	-1.4	-1.3	-1.4	0.6	0.8
Active lever presses in extinction session 6	2.9	2.8	4.0	-1.6	-2.0	-2.0	-1.8	1.7	1.8	1.8	-1.8	-1.7	-1.7	-1.0	-0.9
Bone: final force	0.7	1.1	2.9	0.6	0.7	0.7	0.7	-0.7	-0.7	-1.2	1.7	1.7	1.7	-0.6	-0.8
Bone: final moment	0.6	0.9	2.3	0.5	0.6	0.6	0.6	-0.6	-0.6	-1.0	1.5	1.5	1.5	-0.7	-0.8
Food consumed during 24 hour testing period	0.4	0.5	0.6	0.8	0.8	0.8	0.8	-0.8	-0.8	-0.8	0.8	0.8	0.8	0.4	0.4
Glucose	1.1	1.7	2.3	1.5	1.4	1.4	1.3	-1.4	-1.4	-1.4	1.3	1.2	1.3	1.1	0.7
Heart weight	0.3	0.4	0.9	-0.3	-0.5	-0.5	-0.4	0.2	0.4	0.6	-0.9	-0.9	-0.9	-0.9	0.5
Delay discount hyperbolic model param	1.9	2.1	3.3	-1.3	-1.5	-1.5	-1.4	1.4	1.4	1.6	-1.8	-1.8	-1.8	-0.2	-0.1
Intermittent access intake day 1-15 change	5.2	5.1	8.1	-2.5	-2.2	-2.2	-2.2	2.5	2.2	2.6	-2.8	-2.7	-2.8	-0.4	-0.4
Intermittent access intake escalation	4.2	4.1	8.7	-1.9	-1.6	-1.6	-1.7	2.0	1.7	2.3	-3.0	-2.9	-2.9	0.6	0.6
Intermittent access intake escalation 2	5.3	5.3	10.2	-2.0	-2.1	-2.1	-2.1	2.2	2.1	2.6	-3.2	-3.2	-3.2	0.0	0.4
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.9	-0.2	-0.5	-0.5	-0.2	0.3	0.3	0.5	-0.9	-0.9	-0.9	0.4	0.7
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.7	-0.8	-0.5	-0.5	-0.2	0.5	0.2	0.5	-0.8	-0.7	-0.7	0.2	0.4
Intermitt. access escalation Index	0.4	0.4	1.6	0.0	-0.1	-0.1	-0.2	0.1	0.2	-0.2	0.7	0.8	0.8	-1.0	-1.2
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.1	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.2	0.4	0.4	-0.2	-0.0
Intermittent access day 15 total infusions	1.1	1.3	2.9	-1.3	-0.9	-0.9	-0.8	1.2	0.9	1.2	-1.7	-1.5	-1.5	0.4	0.3
Intermittent access terminal intake (last 3 days)	0.9	0.9	1.6	-0.9	-1.1	-1.1	-0.9	1.0	1.0	1.1	-1.3	-1.0	-1.0	-0.5	-0.3
Intermittent access total infusions	0.1	0.1	0.4	-0.6	-0.2	-0.2	-0.1	0.4	0.1	0.3	-0.6	-0.4	-0.4	0.2	0.3
Intermittent access day 1 locomotion	0.2	0.2	0.6	-0.8	-0.5	-0.5	-0.1	0.5	0.2	0.4	-0.7	-0.5	-0.5	0.2	0.3
Intermittent access day 15 total locomotion	2.6	2.8	4.9	-2.0	-1.8	-1.8	-1.4	1.8	1.5	1.8	-2.2	-1.9	-2.0	-0.2	-0.1
Intermittent access total locomotion	0.9	1.0	1.9	-1.4	-1.2	-1.2	-0.8	1.2	0.9	1.0	-1.2	-1.0	-1.0	-0.4	-0.2
Intermittent access standard deviation	2.3	2.4	4.5	-1.3	-1.5	-1.5	-1.5	1.5	1.5	1.8	-2.1	-2.0	-2.0	0.2	-0.0
Left kidney weight	0.3	0.8	4.8	-0.5	-0.6	-0.6	-0.9	0.7	0.8	0.5	-0.0	-0.1	-0.1	-2.2	-1.3
Right kidney weight	1.6	4.4	6.2	-2.2	-2.2	-2.2	-2.2	2.1	2.2	2.2	-1.9	-2.0	-2.0	-2.5	-1.3
Cocaine induced anxiety	1.4	1.6	2.6	-1.0	-1.6	-1.6	-1.5	1.2	1.5	1.2	-0.6	-0.7	-0.7	-1.3	-1.6
Post-drug Anxiety	1.2	1.3	3.9	-0.4	-1.4	-1.4	-1.5	1.0	1.5	1.0	-0.3	-0.4	-0.4	-1.0	-2.0
Baseline Anxiety	0.2	0.2	1.0	0.5	0.3	0.3	0.2	-0.1	-0.2	-0.0	-0.2	-0.2	-0.2	1.0	0.6
Tail length	2.4	7.3	11.2	-2.8	-2.7	-2.7	-2.7	2.7	2.7	3.0	-3.3	-3.3	-3.3	-0.8	-0.4
Length with tail	1.9	6.9	11.6	-3.4	-2.9	-2.9	-2.6	2.9	2.7	2.7	-2.6	-2.6	-2.7	-1.8	-1.2
Length without tail	0.4	0.8	2.4	-1.6	-0.9	-0.9	-0.6	1.1	0.7	0.4	-0.0	0.0	-0.1	-1.5	-1.2
Times rat made contact with spout	0.4	0.5	1.0	0.8	0.8	0.8	0.7	-0.8	-0.8	-0.5	0.3	0.2	0.3	1.0	1.0
Lifetime Intake	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.1	0.3	0.1	0.2	-0.4	-0.1	-0.1	-0.1	0.0
Liver weight, left	2.6	4.1	6.0	2.4	2.2	2.2	2.2	-2.3	-2.1	-2.1	1.8	1.9	1.8	1.5	1.4
Liver weight, right	1.4	2.3	3.0	1.5	1.5	1.5	1.6	-1.6	-1.5	-1.7	1.7	1.7	1.7	0.8	0.5
Locomotor activity	4.1	6.5	10.4	-3.2	-2.9	-2.9	-2.7	2.9	2.7	2.5	-2.0	-2.0	-2.0	-2.1	-2.1
Locomotor testing distance	2.2	3.7	5.6	-2.4	-2.2	-2.2	-2.0	2.2	2.0	1.9	-1.7	-1.6	-1.6	-1.5	-1.4
Locomotor testing rearing	0.0	0.0	0.1	0.1	-0.1	-0.1	0.0	-0.0	0.0	0.1	-0.3	-0.2	-0.3	0.2	0.3
Locomotion in novel chamber	0.3	0.4	1.1	0.1	-0.4	-0.4	-0.9	0.3	0.5	0.7	-0.9	-1.0	-0.8	-0.0	0.1
Locomotion in novel chamber post-restriction	0.5	0.7	0.9	-0.7	-0.9	-0.9	-0.8	0.8	1.0	0.9	-0.9	-0.8	-0.9	-0.4	-0.4
Fecal boli incidents, locomotor time 1	2.2	2.4	3.6	1.9	1.7	1.7	1.6	-1.7	-1.7	-1.6	1.2	1.0	1.2	1.5	1.5
Change in fecal boli incidents, locomotor task	1.1	1.0	2.5	-1.1	-1.0	-1.0	-0.9	1.0	1.2	0.8	-0.3	-0.1	-0.4	-1.6	-1.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	0.1	0.1	0.1	0.1	-0.1	-0.2	-0.4	0.7	0.7	0.8	-0.6	-0.8
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.4	-0.4	-0.4	-0.4	0.3	0.3	0.3	-0.5	-0.5	-0.4	-0.1	0.0
Total resting periods, locomotor time 1	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.5	0.5	0.4	0.5	-0.5	-0.6	-0.4	-0.4	-0.2
Rest time, locomotor task time 1	0.2	0.3	0.4	-0.6	-0.7	-0.7	-0.6	0.5	0.5	0.4	-0.4	-0.3	-0.4	-0.6	-0.5
Distance moved, locomotor task time 1	0.3	0.3	0.7	-0.2	0.2	0.2	0.2	-0.1	-0.2	-0.4	0.8	0.9	0.8	-0.7	-0.8
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.1	0.3	0.3	0.3	-0.3	-0.3	-0.2	0.2	0.0	0.1	0.5	0.4
Time >=10cm from walls, locomotor time 2	1.4	1.4	1.9	1.2	1.3	1.3	1.4	-1.2	-1.4	-1.2	0.9	1.1	1.0	1.2	1.0
Bouts of movement, locomotor time 2	0.8	0.9	1.7	-1.0	-1.0	-1.0	-1.0	1.0	1.0	0.8	-0.4	-0.4	-0.4	-1.3	-1.3
Total resting periods, locomotor time 2	0.9	0.9	2.2	-1.0	-1.0	-1.0	-1.1	1.0	1.0	0.8	-0.3	-0.4	-0.3	-1.5	-1.4
Rest time, locomotor task time 2	0.8	0.9	1.5	-1.0	-1.1	-1.1	-1.1	1.0	0.9	0.9	-0.6	-0.6	-0.4	-1.2	-1.1
Distance moved, locomotor task time 2	1.1	1.2	1.8	0.9	1.2	1.2	1.4	-1.1	-1.3	-1.1	0.8	0.9	0.8	1.3	1.2
Vertical activity count, locomotor time 2	1.4	1.5	2.9	1.2	1.3	1.3	1.5	-1.3	-1.3	-1.1	0.6	0.7	0.5	1.7	1.6
Light reinforcement 1	5.0	9.1	11.8	-3.4	-3.2	-3.2	-3.2	3.4	3.1	3.4	-3.1	-3.1	-3.1	-1.6	-1.5
Light reinforcement 2	1.6	2.1	3.8	-1.9	-1.5	-1.5	-1.5	1.7	1.5	1.5	-1.5	-1.5	-1.5	-0.7	-0.7
Bone: marrow area	0.1	0.3	0.8	0.2	0.2	0.2	0.3	-0.2	-0.2	-0.6	0.8	0.9	0.8	-0.5	-0.6
Bone: maximum diameter	1.3	2.3	3.9	-1.7	-1.7	-1.7	-1.6	1.7	1.7	1.3	-0.7	-0.6	-0.7	-2.0	-2.0
Bone: maximum force	0.8	1.3	3.1	0.8	0.9	0.9	0.9	-0.9	-0.9	-1.3	1.7	1.8	1.7	-0.4	-0.5
Bone: maximum moment	0.6	1.1	2.7	0.7	0.8	0.8	0.8	-0.8	-0.8	-1.2	1.6	1.6	1.6	-0.4	-0.5
Mean time between licks in bursts	2.9	4.1	6.4	-2.0	-2.1	-2.1	-2.0	2.1	2.1	2.3	-2.5	-2.5	-2.5	-0.4	-0.2
Mean num. licks in bursts	0.0	0.1	0.3	-0.2	-0.0	-0.0	-0.2	0.0	0.1	0.1	0.2	0.1	0.2	-0.5	-0.5
Cd content in liver	0.1	0.1	0.2	0.3	0.3	0.3	0.3	-0.3	-0.3	-0.4	0.5	0.5	0.5	0.0	-0.0
Co content in liver	0.4	0.4	0.9	-0.6	-0.6	-0.6	-0.5	0.6	0.5	0.8	-0.9	-0.9	-0.9	0.1	0.3
Cu content in liver	0.3	0.3	1.3	-0.5	-0.3	-0.3	-0.2	0.3	0.2	-0.1	0.5	0.5	0.5	-1.1	-1.1
Fe content in liver	0.1	0.1	0.5	0.3	0.2	0.2	0.2	-0.2	-0.2	-0.0	-0.2	-0.2	-0.2	0.7	0.6
K content in liver	0.4	0.4	1.3	-0.6	-0.5	-0.5	-0.5	0.5	0.5	0.2	0.2	0.2	0.2	-1.1	-1.2
Mg content in liver	0.5	0.5	2.0	-0.6	-0.6	-0.6	-0.6	0.6	0.6	0.3	0.2	0.2	0.2	-1.3	-1.4
Mn content in liver	2.9	3.3	7.9	-1.9	-1.9	-1.9	-2.0	1.9	2.0	1.4	-0.5	-0.5	-0.5	-2.6	-2.8
Na content in liver	0.6	0.7	1.4	0.5	0.7	0.7	0.7	-0.7	-0.7	-0.9	1.2	1.2	1.2	-0.3	-0.4
Rb content in liver	0.3	0.4	1.5	0.1	0.0	0.0	-0.0	-0.0	0.0	-0.4	0.9	0.9	0.9	-1.0	-1.2
Se content in liver	0.2	0.2	0.3	-0.6	-0.5	-0.5	-0.5	0.5	0.5	0.5	-0.4	-0.4	-0.4	-0.5	-0.4
Sr content in liver	0.4	0.4	1.5	0.5	0.5	0.5	0.5	-0.5	-0.5	-0.1	-0.3	-0.3	-0.3	1.2	1.2
Zn content in liver	1.3	1.4	3.5	-0.5	-0.6	-0.6	-0.6	0.6	0.6	1.2	-1.9	-1.9	-1.9	1.1	1.3
Bone: minimum diameter	0.2	0.3	1.2	-0.5	-0.4	-0.4	-0.4	0.4	0.4	0.1	0.3	0.4	0.3	-1.0	-1.1
Time in familiar zone, hab. session 1	1.6	1.5	2.5	-1.1	-1.2	-1.2	-1.2	1.2	1.2	1.4	-1.5	-1.6	-1.5	-0.2	-0.1
Time in novel zone, hab. session 1	0.6	0.6	1.5	0.4	0.5	0.5	0.5	-0.4	-0.5	-0.8	1.2	1.2	1.2	-0.7	-0.8
Total zone transitions, hab. session 1	1.5	2.1	3.3	-1.6	-1.6	-1.6	-1.6	1.5	1.6	1.3	-0.7	-0.8	-0.7	-1.8	-1.8
Total locomotion distance, hab. session 1	2.5	3.6	7.5	-2.1	-2.0	-2.0	-2.1	2.0	2.0	1.5	-0.6	-0.8	-0.6	-2.7	-2.7
Locomotion velocity, hab. session 1	2.5	3.6	5.6	-2.1	-2.1	-2.1	-2.1	2.0	2.1	1.7	-1.0	-1.1	-1.0	-2.4	-2.4
Time in familiar zone, hab. session 2	4.5	4.6	8.0	-2.0	-2.1	-2.1	-2.1	2.1	2.1	2.5	-2.8	-2.8	-2.8	-0.1	0.1
Time in novel zone, hab. session 2	3.1	3.1	5.9	1.5	1.6	1.6	1.6	-1.6	-1.6	-2.0	2.4	2.4	2.4	-0.2	-0.4
Total zone transitions, hab. session 2	0.5	0.6	2.7	-0.3	-0.2	-0.2	-0.4	0.3	0.2	-0.1	0.9	0.7	0.9	-1.5	-1.6
Total locomotion distance, hab. session 2	1.3	1.8	2.8	-1.4	-1.4	-1.4	-1.6	1.4	1.4	1.3	-0.7	-0.9	-0.7	-1.6	-1.7
Locomotion velocity, hab. session 2	1.5	2.1	4.0	-1.6	-1.5	-1.5	-1.7	1.5	1.5	1.3	-0.6	-0.7	-0.6	-1.9	-2.0
Novel to familiar place preference ratio	2.3	2.4	5.2	1.2	1.3	1.3	1.3	-1.3	-1.3	-1.8	2.2	2.3	2.2	-0.6	-0.7
Novelty place preference	1.3	1.4	3.1	0.8	0.9	0.9	0.9	-0.9	-0.9	-1.3	1.7	1.8	1.7	-0.7	-0.8
Time in novel zone, NPP test	1.5	1.6	3.5	0.9	1.0	1.0	1.0	-1.0	-1.0	-1.4	1.8	1.9	1.8	-0.5	-0.7
Total zone transitions, NPP test	0.1	0.2	0.8	-0.3	-0.2	-0.2	-0.3	0.2	0.2	0.1	0.4	0.2	0.4	-0.8	-0.9
Total locomotion distance, NPP test	0.3	0.4	1.7	-0.4	-0.3	-0.3	-0.5	0.3	0.3	0.1	0.5	0.3	0.5	-1.2	-1.3
Locomotion velocity, NPP test	0.4	0.5	1.8	-0.7	-0.6	-0.6	-0.7	0.6	0.6	0.4	0.2	0.0	0.2	-1.3	-1.3
Intraocular pressure	0.4	0.6	2.5	1.0	0.6	0.6	0.3	-0.6	-0.4	-0.0	-0.5	-0.5	-0.5	1.6	1.4
Delta distance traveled before/after self-admin	1.4	1.6	2.2	-1.5	-1.4	-1.4	-1.4	1.4	1.3	1.4	-1.3	-1.4	-1.3	-0.6	-0.6
Delta ambulatory time before/after self-admin	1.8	1.9	2.6	-1.4	-1.5	-1.5	-1.6	1.5	1.5	1.5	-1.3	-1.3	-1.2	-1.1	-1.0
Parametrial fat weight	0.4	0.8	1.3	-1.1	-1.1	-1.1	-0.6	0.9	0.7	0.9	-1.1	-1.0	-1.1	-0.2	0.1
Pavlov. Cond. lever latency	0.3	0.4	1.7	0.6	0.5	0.5	0.5	-0.5	-0.5	-0.1	-0.3	-0.3	-0.3	1.3	1.3
Pavlov. Cond. magazine entry latency	2.0	2.6	3.7	-1.6	-1.7	-1.7	-1.7	1.7	1.7	1.9	-1.9	-1.9	-1.9	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.1	-0.3	-0.3	-0.3	0.3	0.3	0.3	-0.2	-0.3	-0.2	0.3	-0.2
Pavlov. Cond. index score	0.6	0.7	1.1	-0.9	-0.9	-0.9	-1.0	1.0	0.9	0.8	-0.5	-0.5	-0.5	-1.0	-1.1
Pavlov. Cond. latency score	0.8	1.0	2.0	-1.1	-1.1	-1.1	-1.1	1.1	1.1	0.8	-0.4	-0.4	-0.4	-1.4	-1.4
Pavlov. Cond. lever contacts	0.7	0.8	2.8	-0.9	-0.8	-0.8	-0.8	0.8	0.8	0.4	0.1	0.1	0.1	-1.7	-1.6
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	0.7	0.8	0.8	0.8	-0.8	-0.8	-0.9	0.8	0.8	0.8	0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	1.1	0.3	0.2	0.2	0.1	-0.2	-0.1	0.1	-0.4	-0.5	-0.4	1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.4	-1.2	-1.2	-1.2	-1.2	1.2	1.2	1.1	-0.8	-0.8	-0.8	-1.0	-1.1
Pavlov. Cond. response bias	0.9	1.1	1.3	-1.1	-1.1	-1.1	-1.1	1.1	1.1	1.2	-1.1	-1.1	-1.1	-0.6	-0.6
Pavlov. Cond. lever latency	0.9	1.2	1.4	1.2	1.2	1.2	1.2	-1.1	-1.2	-1.2	1.1	1.1	1.1	0.7	0.6
Pavlov. Cond. magazine entry latency	0.7	0.8	1.1	-1.0	-1.0	-1.0	-0.9	1.0	1.0	0.9	-0.8	-0.6	-0.8	-0.8	-0.8
Pavlov. Cond. change in total contacts	0.8	1.1	1.5	-1.1	-1.0	-1.0	-1.1	1.0	1.1	1.2	-1.2	-1.2	-1.2	-0.4	-0.3
Pavlov. Cond. index score	0.9	1.2	1.5	-1.2	-1.2	-1.2	-1.1	1.1	1.2	1.2	-1.2	-1.1	-1.2	-0.6	-0.5
Pavlov. Cond. latency score	1.0	1.2	1.5	-1.2	-1.2	-1.2	-1.1	1.2	1.2	1.2	-1.1	-1.0	-1.1	-0.8	-0.7
Pavlov. Cond. lever contacts	0.6	0.9	1.4	-0.9	-0.9	-0.9	-1.0	0.9	1.0	1.1	-1.2	-1.2	-1.2	-0.2	-0.2
Pavlov. Cond. magazine entry number	1.1	1.3	1.7	1.3	1.3	1.3	1.2	-1.3	-1.3	-1.2	1.0	0.9	1.0	1.0	0.9
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.4	1.2	1.1	1.1	1.1	-0.9	-1.2	-0.9	0.7	0.6	0.7	1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.6	-1.3	-1.3	-1.3	-1.2	1.2	1.3	1.2	-1.2	-1.1	-1.2	-0.8	-0.7
Pavlov. Cond. response bias	1.6	2.1	3.2	-1.5	-1.5	-1.5	-1.5	1.4	1.5	1.7	-1.8	-1.7	-1.8	-0.4	-0.3
Time in closed arm before self-admin	0.5	0.6	1.6	0.0	0.3	0.3	0.4	-0.3	-0.5	-0.8	1.2	1.2	1.3	-0.7	-0.8
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	0.1	0.1	-0.2	-0.1	0.1	0.1	-0.0	-0.3	-0.2	0.1	0.1
Time in open arm before self-admin	0.8	0.9	1.6	-0.8	-1.0	-1.0	-0.9	0.9	0.9	1.1	-1.2	-1.2	-1.2	-0.1	-0.0
Time in open arm after self-admin	0.7	0.7	1.4	0.6	0.8	0.8	1.2	-0.8	-1.1	-1.0	0.8	0.9	0.8	0.8	0.7
Bone: periosteal estimation	0.3	0.7	1.8	-0.1	0.0	0.0	0.1	-0.0	-0.0	-0.6	1.2	1.3	1.2	-1.2	-1.3
Bone: periosteal perimeter	0.6	1.0	2.9	-1.0	-1.0	-1.0	-0.9	1.0	1.0	0.5	0.1	0.2	0.1	-1.7	-1.7
Bone: post-yield work	0.6	0.8	1.1	0.9	0.9	0.9	1.0	-0.9	-0.9	-1.0	1.0	1.0	1.0	0.4	0.4
Progressive ratio test 1 active lever presses	0.2	0.2	0.5	0.2	0.4	0.4	0.7	-0.5	-0.7	-0.5	0.2	0.4	0.3	-0.2	0.7
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	0.3	0.4	0.4	0.7	-0.6	-0.7	-0.6	0.3	0.5	0.5	-0.4	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.0	0.1	0.0	0.0	-0.1	0.0	-0.0	0.1	-0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.0	-0.2	-0.2	-0.2	0.2	0.2	0.4	-0.7	-0.5	-0.6	0.7	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	-0.2	-0.5	-0.5	-0.5	0.5	0.6	0.6	-0.7	-0.5	-0.6	0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.2	0.3	0.2	0.2	-0.3	-0.1	-0.1	-0.2	-0.2
Incentive Sensitization - Responses	0.4	0.4	2.2	0.4	-0.2	-0.2	-0.4	0.2	0.4	0.6	-0.8	-0.7	-0.7	1.5	0.3
Incentive Sensitization - Breakpoint	0.4	0.4	1.6	0.4	-0.3	-0.3	-0.6	0.3	0.6	0.7	-0.8	-0.7	-0.8	1.3	0.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.1	0.2	0.2	0.2	-0.1	-0.2	-0.1	-0.1	0.0	-0.0	0.2	0.3
Progressive ratio	0.4	0.5	1.3	1.1	0.8	0.8	0.6	-0.8	-0.5	-0.5	0.2	0.2	0.2	0.9	0.7
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.0	-0.3	-0.3	-0.4	0.3	0.3	0.4	-0.2	-0.4	-0.2	-0.2	-0.1
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	-0.8	-0.6	-0.6	-0.4	0.6	0.3	0.4	-0.1	-0.2	-0.1	-0.6	-0.4
Retroperitoneal fat weight	0.5	1.5	2.8	0.8	1.2	1.2	1.7	-1.2	-1.6	-1.4	1.1	1.2	1.1	1.0	1.3
Reaction time number correct	1.1	1.6	2.8	1.7	1.3	1.3	1.3	-1.4	-1.4	-1.1	0.6	0.5	0.6	1.5	1.6
Reaction time mean minus median	0.8	1.1	1.6	-0.8	-1.1	-1.1	-1.3	1.0	1.2	1.1	-1.0	-1.1	-1.0	-0.8	-0.7
Reaction time mean minus median AUC	0.6	0.8	2.9	-0.6	-0.8	-0.8	-0.9	0.8	0.9	0.4	0.1	0.2	0.2	-1.7	-1.7
Reaction time num false alarms	0.1	0.2	0.5	0.7	0.6	0.6	0.4	-0.4	-0.3	-0.2	0.1	0.2	0.1	0.5	0.5
Reaction time num false alarms AUC	0.4	0.5	1.1	1.1	0.9	0.9	0.7	-0.7	-0.6	-0.4	0.1	0.2	0.1	0.9	0.9
Reaction time trials correct on left	1.1	1.6	2.8	1.7	1.3	1.3	1.3	-1.4	-1.4	-1.1	0.6	0.5	0.6	1.5	1.6
Reaction time trials on left	1.1	1.5	2.7	1.6	1.3	1.3	1.3	-1.4	-1.3	-1.0	0.6	0.6	0.6	1.5	1.5
Reaction time mean	0.3	0.4	1.5	-0.3	-0.6	-0.6	-0.6	0.4	0.6	0.1	0.3	0.2	0.3	-1.2	-1.2
Reaction time mean AUC	0.3	0.3	1.3	-0.3	-0.5	-0.5	-0.4	0.4	0.4	0.0	0.4	0.4	0.4	-1.1	-1.1
Median of all reaction times	0.3	0.3	1.0	0.1	-0.1	-0.1	-0.0	-0.1	-0.0	-0.4	0.8	0.8	0.8	-0.9	-1.0
Reaction time omissions	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.7	0.8	0.7	0.6	-0.5	-0.4	-0.5	-0.6	-0.6
Reaction time false alarm rate	0.0	0.0	0.0	0.2	0.2	0.2	0.0	-0.0	0.1	-0.0	0.1	0.1	0.1	-0.2	-0.2
Reaction time premature initiation rate	0.6	0.9	1.7	-0.9	-0.9	-0.9	-0.6	0.8	0.6	0.9	-1.3	-1.3	-1.3	0.6	0.6
Reaction time premature initiations	0.5	0.7	2.3	-0.1	-0.2	-0.2	0.1	0.1	-0.1	0.5	-1.1	-1.1	-1.1	1.4	1.5
Std. dev. reaction times	0.5	0.7	1.3	-0.5	-0.9	-0.9	-1.0	0.8	1.0	0.7	-0.5	-0.5	-0.4	-1.1	-1.0
Reaction time trials completed	1.1	1.5	2.7	1.6	1.3	1.3	1.3	-1.4	-1.3	-1.0	0.6	0.6	0.6	1.5	1.5
Reaction time trials AUC	1.2	1.7	3.0	1.7	1.4	1.4	1.4	-1.4	-1.4	-1.0	0.5	0.5	0.5	1.7	1.7
Run reversals in cocaine runway, females	1.0	0.9	1.7	-0.6	-1.0	-1.0	-1.3	0.9	1.1	1.0	-0.5	-0.9	-0.6	-1.2	-1.1
Run reversals in cocaine runway, males	1.5	1.4	2.0	-1.0	-1.4	-1.4	-1.4	1.1	1.4	1.3	-0.9	-1.0	-0.9	-1.3	-1.2
Latency to leave start box in cocaine runway	1.9	2.1	3.2	-1.8	-1.7	-1.7	-1.6	1.6	1.5	1.2	-0.8	-0.7	-0.6	-1.7	-1.8
Latency to leave start box in cocaine runway, F	1.1	1.2	4.3	-0.9	-1.0	-1.0	-0.9	0.8	0.8	0.3	0.4	0.4	0.5	-2.0	-2.1
Latency to leave start box in cocaine runway, M	2.0	1.9	4.1	-1.1	-1.2	-1.2	-1.2	1.2	1.2	1.5	-2.0	-1.9	-2.0	0.3	0.5
Std. dev. time between licks in bursts	1.3	1.5	2.1	-1.4	-1.4	-1.4	-1.3	1.4	1.3	1.1	-0.7	-0.7	-0.7	-1.5	-1.4
Total sessions with >9 infusions	0.3	0.3	1.5	-0.1	-0.6	-0.6	-0.4	0.3	0.5	0.2	0.1	0.3	0.2	-1.2	-1.0
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.0	-0.0	-0.1	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.0
Short access day 10 total inactive lever presses	0.1	0.1	0.6	-0.3	0.0	0.0	0.2	-0.0	-0.2	0.1	-0.4	-0.4	-0.4	-0.3	0.7
Short access day 1 total infusions	0.5	0.5	2.3	-0.6	-0.7	-0.7	-0.7	0.6	0.7	0.4	-0.2	0.1	0.0	-1.5	-1.1
Short access day 10 total infusions	0.1	0.1	0.6	0.5	0.1	0.1	0.0	-0.0	-0.0	0.0	-0.2	0.1	0.1	0.8	0.0
Short access total infusions	0.1	0.1	0.6	0.2	-0.3	-0.3	-0.3	0.1	0.3	0.1	-0.0	0.3	0.2	-0.8	-0.6
Short access day 1 locomotion	1.1	1.2	3.5	-1.9	-1.1	-1.1	-0.9	1.4	0.9	0.9	-0.9	-0.6	-0.7	-1.3	-0.8
Short access day 10 total locomotion	3.0	3.3	5.8	-2.0	-1.8	-1.8	-1.7	2.0	1.7	2.1	-2.4	-2.3	-2.3	0.1	-0.1
Short access total locomotion	1.0	1.0	1.7	-1.3	-1.2	-1.2	-0.9	1.1	1.0	1.0	-1.1	-0.8	-0.8	-0.9	-0.6
One hour access (0.3 mA shock)	0.3	0.3	0.5	0.1	0.7	0.7	0.7	-0.4	-0.7	-0.6	0.4	0.6	0.5	0.5	0.4
Compulsive drug intake	0.6	0.7	1.4	0.5	1.0	1.0	0.7	-0.7	-0.7	-0.9	1.2	1.0	0.9	0.3	-0.1
One hour access (shock baseline)	0.1	0.2	0.9	-0.1	0.2	0.2	0.3	0.0	-0.3	-0.0	-0.4	-0.2	-0.2	1.0	0.7
Social response proportion	0.8	0.8	1.3	-0.9	-1.1	-1.1	-1.0	0.8	1.1	0.9	-0.7	-0.7	-0.7	-0.9	-0.8
Social responses	8.0	10.3	13.5	-3.4	-3.7	-3.7	-3.5	3.3	3.6	3.4	-3.0	-2.8	-3.0	-2.5	-2.3
Social time	0.7	0.9	1.5	0.8	1.0	1.0	1.2	-1.0	-1.1	-1.1	0.9	1.0	0.9	0.8	0.8
Soleus weight	7.5	22.0	28.2	4.8	5.0	5.0	5.0	-5.0	-4.9	-5.3	5.2	5.2	5.1	2.2	2.1
Bone: stiffness	2.2	3.4	6.1	1.7	1.8	1.8	1.7	-1.8	-1.8	-2.1	2.5	2.4	2.4	0.2	0.0
Tibialis anterior weight	0.8	2.7	3.5	1.9	1.7	1.7	1.7	-1.7	-1.6	-1.8	1.8	1.8	1.8	1.1	0.6
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.2	-0.9	-1.2	-1.2	-1.4	1.2	1.4	1.0	-0.5	-0.5	-0.5	-1.8	-1.7
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	0.8	-0.0	-0.0	0.1	-0.4	-0.1	0.1	-0.4	-0.6	-0.5	0.8	0.9
Time to tail flick, test, before self-admin	0.9	0.8	2.7	-0.4	-1.0	-1.0	-0.9	0.7	1.0	0.6	-0.1	0.1	-0.0	-1.6	-1.6
Time to tail flick, test, after self-admin	0.4	0.5	1.3	-0.3	-0.8	-0.8	-0.8	0.6	0.8	0.6	-0.3	-0.2	-0.2	-1.1	-1.0
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	3.5	1.6	1.1	1.1	1.3	-1.4	-1.3	-0.9	0.4	0.4	0.3	1.9	1.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.1	0.2	0.2	0.1	-0.0	-0.1	0.1	-0.5	-0.5	-0.4	0.8	0.9
Tibia length	0.7	2.1	3.1	-1.6	-1.5	-1.5	-1.3	1.5	1.4	1.6	-1.8	-1.7	-1.8	-0.7	-0.2
Ambulatory time before self-admin	0.1	0.1	0.4	0.5	0.2	0.2	0.3	-0.4	-0.3	-0.4	0.4	0.4	0.5	0.6	-0.0
Ambulatory time after self-admin	0.6	0.7	1.2	-0.8	-1.1	-1.1	-0.9	0.7	0.8	0.8	-0.7	-0.8	-0.8	-0.5	-0.5
Bone: tissue strength	1.4	1.3	2.5	1.1	1.1	1.1	1.2	-1.1	-1.1	-1.4	1.5	1.6	1.5	0.2	0.2
Total heroin consumption	1.9	2.2	3.1	-1.2	-1.8	-1.8	-1.6	1.4	1.6	1.6	-1.5	-1.4	-1.4	-1.6	-0.9
Bone: trabecular number	1.7	2.7	4.8	-1.8	-1.8	-1.8	-1.9	1.8	1.8	1.4	-0.7	-0.8	-0.7	-2.1	-2.2
Bone: trabecular spacing	2.2	2.9	7.6	1.8	1.7	1.7	1.7	-1.7	-1.7	-1.1	0.1	0.1	0.1	2.7	2.8
Bone: trabecular thickness	2.8	3.3	12.0	-1.7	-1.6	-1.6	-1.6	1.6	1.6	0.7	0.7	0.6	0.7	-3.3	-3.5
Bone: trabecular tissue density	2.9	4.1	5.6	2.2	2.2	2.2	2.4	-2.2	-2.2	-2.1	1.6	1.8	1.6	1.9	1.9
Water consumed over 24 hours	0.3	0.4	1.0	0.2	0.3	0.3	0.3	-0.3	-0.3	-0.6	1.0	1.0	1.0	-0.7	-0.8
Number of responses in last shaping day	0.2	0.3	0.6	-0.6	-0.8	-0.8	-0.4	0.5	0.4	0.4	-0.4	-0.3	-0.3	-0.6	-0.3