Hub : Genes

Tlcd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Tlcd1	0.03	0.02	8.1e-04	0.01	0.03	0.02	0.02	7.7e-03	6.3e-04	3.7e-03	2.4e-03
2	Brain	gene expression	Tlcd1	0.05	0.04	2.3e-05	0.04	0.04	0.05	0.04	5.6e-05	4.6e-05	3.3e-05	6.8e-05
3	Liver	gene expression	Tlcd1	0.27	0.29	3.1e-03	0.01	0.01	0.01	0.01	1.4e-02	1.5e-02	3.5e-02	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	2.1	3.9	3.9	2.0	-1.9	-2.0
Area under the delay curve	1.6	2.4	3.0	-1.6	1.3	1.7
BMI with tail	1.7	5.9	6.2	2.5	-2.5	-2.3
BMI without tail	1.2	6.3	6.7	2.6	-2.4	-2.6
Body weight	2.5	10.8	11.7	3.4	-3.1	-3.3
Weight adjusted by age	0.1	0.2	0.3	0.4	-0.6	-0.5
Bone surface	1.5	3.0	3.1	1.7	-1.8	-1.7
Bone volume	1.3	2.6	2.6	1.6	-1.6	-1.6
Breakpoint value in progressive ratio session	0.4	0.7	1.0	0.9	-0.6	-1.0
Number of licking bursts	0.1	0.4	0.4	-0.6	0.6	0.6
Context. condit. distance diff. score	0.6	0.7	0.8	0.8	-0.9	-0.8
Locomotion velocity, session 1	2.0	2.2	2.4	1.6	-1.4	-1.5
Locomotion distance, session 1	0.2	0.2	0.3	0.6	-0.2	-0.5
Locomotion velocity, session 2	0.0	0.0	0.1	0.2	-0.1	-0.2
Locomotion distance, session 2	1.3	1.8	2.0	1.3	-1.4	-1.3
Locomotion velocity, session 3	3.1	3.5	3.8	-2.0	1.8	1.9
Locomotion distance, session 3	0.4	0.5	0.5	-0.7	0.7	0.7
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	-0.2	-0.2
Stereotopy head waving duration, day 3	0.3	0.4	0.5	-0.7	0.7	0.5
Locomotion velocity, session 7	0.3	0.4	0.5	0.6	-0.5	-0.7
Locomotion distance, session 7	0.5	0.6	0.7	0.8	-0.6	-0.8
Stereotopy head waving bouts, day 7	0.6	0.7	0.9	0.8	-1.0	-0.8
Stereotopy head waving duration, day 7	0.3	0.4	0.4	0.5	-0.6	-0.6
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	-0.2	-0.1
Locomotion distance, session 8	0.9	1.2	1.4	1.1	-1.2	-1.1
Degree of sensitization distance	3.1	3.4	3.6	1.9	-1.8	-1.9
Degree of sensitization stereotypy	0.7	0.7	0.9	0.8	-0.9	-0.8
Conditioned locomotion	1.5	1.7	1.8	-1.3	1.3	1.3
Cocaine response after cond. corrected	1.3	2.0	2.4	1.4	-1.5	-1.3
Cocaine response after cond. not corrected	1.8	2.6	3.1	1.6	-1.8	-1.5
Cocaine response before conditioning	0.2	0.2	0.3	0.5	-0.4	-0.5
Saline control response	0.0	0.0	0.0	-0.0	-0.0	-0.1
Bone: connectivity density	3.9	6.2	6.3	2.5	-2.5	-2.5
Bone: cortical apparent density	0.4	0.6	0.8	-0.8	0.9	0.7
Bone: cortical area	1.4	2.3	2.5	-1.5	1.6	1.5
Bone: cortical porosity	0.2	0.3	0.3	0.6	-0.4	-0.6
Bone: cortical porosity	0.1	0.1	0.1	0.4	-0.3	-0.3
Bone: cortical thickness	2.9	4.8	5.2	-2.2	2.3	2.1
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.2	0.1
Bone: cortical tissue density	0.2	0.4	0.5	-0.6	0.7	0.5
Condit. Reinf. active minus inactive responses	0.6	0.7	0.8	-0.9	0.9	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.4	0.4	0.4
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	0.1	0.1
Condit. Reinf. inactive responses	0.3	0.4	0.4	0.6	-0.6	-0.6
Incentive salience index mean	0.2	0.3	0.3	-0.6	0.4	0.6
Condit. Reinf. lever presses	0.1	0.2	0.3	0.3	-0.6	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.6	0.7	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.7	-0.8	0.8	0.6
Condit. Reinf. active responses	0.1	0.2	0.3	-0.4	0.5	0.2
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.1	-0.2
Condit. Reinf. lever presses	2.3	3.3	3.5	-1.9	1.8	1.8
Condit. Reinf. lever reinforcers received	0.3	0.5	0.6	-0.7	0.8	0.5
Conditioned reinforcement - actives	0.1	0.4	0.4	0.6	-0.7	-0.6
Conditioned reinforcement - inactives	0.0	0.1	0.1	0.4	-0.3	-0.3
Conditioned locomotion	0.3	0.4	0.8	0.5	-0.9	-0.4
Patch foraging indifference point 0 sec	0.2	0.7	0.9	-0.8	0.9	0.7
Patch foraging indifference point AUC	1.2	2.8	3.1	-1.8	1.5	1.7
Delay disc. indifference point, 0s delay	1.0	1.2	1.3	-1.0	1.1	1.1
Delay disc. indifference point, 16s delay	1.2	1.8	2.4	-1.3	1.1	1.5
Delay disc. indifference point, 2s delay	2.7	3.0	3.0	-1.7	1.7	1.7
Delay disc. indifference point, 24s delay	0.5	0.8	1.0	0.8	-1.0	-0.8
Delay disc. indifference point, 4s delay	0.3	0.3	0.3	-0.5	0.6	0.6
Delay disc. indifference point, 8s delay	0.6	1.1	1.6	-1.1	0.6	1.3
Indifference point function ln k	0.2	0.7	1.0	1.0	-0.6	-1.0
Indifference point function log k	0.2	0.7	1.0	1.0	-0.6	-1.0
Patch foraging total patch changes 0 sec	0.2	0.5	0.7	-0.7	0.8	0.5
Patch foraging total patch changes 12 sec	0.2	0.2	0.3	-0.5	0.5	0.5
Patch foraging total patch changes 18 sec	1.0	2.4	2.7	-1.5	1.6	1.5
Patch foraging total patch changes 24 sec	0.8	2.8	3.1	-1.8	1.6	1.6
Patch foraging total patch changes 6 sec	2.8	4.8	5.2	-2.3	2.1	2.2
Patch foraging time to switch 0 sec	0.6	2.4	2.9	1.6	-1.7	-1.3
Patch foraging water rate 0 sec	0.8	3.0	3.6	-1.7	1.9	1.5
Patch foraging water rate 12 sec	0.1	0.3	0.5	0.6	-0.2	-0.7
Patch foraging water rate 18 sec	0.3	0.7	0.8	0.8	-0.7	-0.9
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.5	0.7	0.5
Patch foraging water rate 6 sec	1.1	1.6	2.3	-1.2	1.5	1.1
Seeking ratio, delayed vs. immediate footshock	1.6	2.3	2.6	-1.6	1.4	1.6
Distance traveled before self-admin	2.2	4.8	4.9	-2.2	2.2	2.2
Distance traveled after self-admin	0.1	0.1	0.1	-0.3	0.3	0.4
Extensor digitorum longus weight	0.8	3.2	3.8	1.7	-1.9	-1.7
Bone: elastic displacement	2.8	3.5	3.5	-1.9	1.9	1.9
Bone: elastic work	8.8	11.6	12.9	-3.3	3.6	3.3
Bone: endosteal estimation	0.0	0.0	0.0	-0.1	0.0	0.2
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	-0.1	0.0
Epididymis fat weight	5.3	26.7	27.9	5.3	-5.1	-5.1
Delta time in closed arm before/after self-admin	2.9	2.7	2.8	-1.7	1.6	1.6
Delta time in open arm before/after self-admin	5.1	6.0	6.5	2.5	-2.6	-2.3
Diff in mean of infusions in LGA sessions	0.4	0.7	0.7	0.8	-0.8	-0.8
Delay discount exponential model param	1.2	1.6	2.0	1.3	-1.1	-1.4
Extinction: sum of active levers before priming	0.7	1.1	1.3	1.1	-0.9	-1.2
Active lever presses in extinction session 6	0.3	0.3	0.6	0.6	-0.3	-0.8
Bone: final force	0.4	0.6	0.6	-0.7	0.8	0.8
Bone: final moment	0.4	0.7	0.8	-0.8	0.9	0.8
Food consumed during 24 hour testing period	0.1	0.3	0.6	-0.4	0.8	0.3
Glucose	1.3	2.1	2.4	-1.5	1.3	1.5
Heart weight	1.6	2.5	2.9	1.7	-1.4	-1.7
Delay discount hyperbolic model param	1.6	2.1	2.4	1.5	-1.3	-1.6
Intermittent access intake day 1-15 change	0.0	0.1	0.2	0.2	-0.4	-0.2
Intermittent access intake escalation	0.0	0.2	0.3	0.3	-0.6	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.4	0.2	0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.4	0.3	0.4
Intermitt. access day 15 inactive lever presses	0.1	0.7	0.7	-0.8	0.8	0.8
Intermitt. access escalation Index	0.3	1.0	1.2	1.0	-1.1	-0.8
Intermittent access day 1 total infusions	0.1	0.2	0.3	0.3	-0.5	-0.2
Intermittent access day 15 total infusions	0.5	1.3	1.9	1.0	-1.4	-1.0
Intermittent access terminal intake (last 3 days)	0.7	1.3	1.7	1.1	-1.3	-1.0
Intermittent access total infusions	0.4	0.5	0.9	0.5	-1.0	-0.4
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.1	-0.3	0.0
Intermittent access day 15 total locomotion	0.1	0.6	0.8	0.7	-0.9	-0.7
Intermittent access total locomotion	0.6	0.7	1.1	0.7	-1.0	-0.7
Intermittent access standard deviation	0.0	0.0	0.0	-0.1	-0.2	0.2
Left kidney weight	0.0	0.2	0.2	0.5	-0.3	-0.4
Right kidney weight	0.1	0.7	0.8	0.8	-0.7	-0.9
Cocaine induced anxiety	0.1	0.2	0.2	-0.4	0.5	0.5
Post-drug Anxiety	0.2	0.2	0.3	0.5	-0.4	-0.5
Baseline Anxiety	0.3	0.5	0.6	0.7	-0.6	-0.8
Tail length	0.3	1.6	1.9	1.4	-1.1	-1.3
Length with tail	0.5	2.2	2.6	1.6	-1.3	-1.5
Length without tail	0.2	0.9	1.0	1.0	-0.9	-0.9
Times rat made contact with spout	0.0	0.0	0.1	-0.1	0.3	0.1
Lifetime Intake	0.5	0.6	1.1	0.7	-1.1	-0.5
Liver weight, left	5.0	8.6	9.1	2.9	-3.0	-2.9
Liver weight, right	3.9	6.8	7.0	2.7	-2.5	-2.6
Locomotor activity	0.0	0.0	0.0	-0.2	0.2	-0.0
Locomotor testing distance	0.0	0.1	0.1	-0.3	0.2	0.1
Locomotor testing rearing	0.0	0.0	0.0	-0.2	0.2	0.1
Locomotion in novel chamber	2.3	3.1	3.8	-1.9	1.4	1.9
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.0	-0.3	-0.0
Fecal boli incidents, locomotor time 1	0.9	2.4	2.5	1.5	-1.5	-1.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.5	0.3	0.6
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	-0.2	-0.2
Bouts of movement, locomotor time 1	0.5	0.6	0.6	-0.7	0.8	0.8
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.3	0.4	0.3
Rest time, locomotor task time 1	0.2	0.3	0.3	0.5	-0.5	-0.6
Distance moved, locomotor task time 1	0.2	0.5	0.6	-0.7	0.7	0.8
Vertical activity count, locomotor time 1	0.0	0.2	0.3	-0.4	0.3	0.6
Time >=10cm from walls, locomotor time 2	0.4	1.1	1.2	1.0	-1.1	-1.0
Bouts of movement, locomotor time 2	0.2	0.5	0.8	-0.6	0.9	0.6
Total resting periods, locomotor time 2	0.0	0.1	0.3	-0.3	0.5	0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.1	-0.1	-0.4
Distance moved, locomotor task time 2	0.4	0.5	0.8	-0.7	0.5	0.9
Vertical activity count, locomotor time 2	0.3	0.8	1.4	-0.8	0.5	1.2
Light reinforcement 1	0.0	0.0	0.1	-0.2	0.0	0.2
Light reinforcement 2	0.3	0.6	0.7	-0.8	0.7	0.9
Bone: marrow area	0.0	0.0	0.0	-0.1	0.1	0.2
Bone: maximum diameter	0.4	0.7	0.8	-0.8	0.8	0.9
Bone: maximum force	0.5	1.0	1.1	-1.0	1.0	1.0
Bone: maximum moment	0.7	1.2	1.3	-1.1	1.1	1.1
Mean time between licks in bursts	0.1	0.8	0.9	0.9	-0.9	-0.8
Mean num. licks in bursts	0.2	0.4	0.4	0.7	-0.6	-0.6
Cd content in liver	0.8	0.9	1.0	-1.0	0.9	1.0
Co content in liver	0.2	0.3	0.4	-0.6	0.3	0.6
Cu content in liver	1.6	1.9	2.3	-1.3	1.5	1.2
Fe content in liver	2.1	2.6	2.9	1.6	-1.7	-1.6
K content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3
Mg content in liver	0.6	0.7	0.8	-0.8	0.9	0.7
Mn content in liver	0.2	0.2	0.2	-0.5	0.4	0.4
Na content in liver	0.0	0.0	0.1	0.1	-0.2	0.1
Rb content in liver	0.1	0.1	0.1	0.3	-0.3	-0.2
Se content in liver	0.6	0.7	0.8	-0.8	0.9	0.7
Sr content in liver	0.5	0.4	0.4	0.7	-0.6	-0.7
Zn content in liver	0.3	0.4	0.4	0.7	-0.5	-0.7
Bone: minimum diameter	0.1	0.1	0.1	-0.4	0.3	0.4
Time in familiar zone, hab. session 1	0.3	0.4	0.4	-0.6	0.5	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.2	0.4	-0.4	-0.5
Total zone transitions, hab. session 1	0.0	0.1	0.1	-0.2	0.1	0.3
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.3	0.4	0.3
Locomotion velocity, hab. session 1	0.3	0.5	0.5	-0.7	0.7	0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	0.4	0.3
Time in novel zone, hab. session 2	0.2	0.2	0.2	-0.4	0.4	0.5
Total zone transitions, hab. session 2	0.3	0.4	0.5	0.6	-0.7	-0.6
Total locomotion distance, hab. session 2	0.0	0.0	0.1	-0.2	0.2	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.3	0.2	0.2
Novel to familiar place preference ratio	0.7	0.9	0.9	1.0	-0.9	-0.9
Novelty place preference	0.9	1.2	1.2	1.1	-1.1	-1.1
Time in novel zone, NPP test	1.0	1.3	1.3	1.1	-1.1	-1.1
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	-0.2	-0.1
Total locomotion distance, NPP test	0.8	1.1	1.2	-1.1	1.0	1.0
Locomotion velocity, NPP test	0.9	1.4	1.4	-1.2	1.1	1.2
Intraocular pressure	1.0	1.6	1.6	-1.3	1.3	1.3
Delta distance traveled before/after self-admin	3.0	3.3	3.4	1.8	-1.7	-1.8
Delta ambulatory time before/after self-admin	1.5	2.6	2.7	1.6	-1.6	-1.6
Parametrial fat weight	6.3	14.8	15.1	3.9	-3.8	-3.9
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.2	0.0	-0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.2	-0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.6	0.3	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.2	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	-0.2	0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	-0.3	0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	0.4	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.3	-0.5	0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.3	0.0	0.4
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.1	-0.1	0.2
Pavlov. Cond. lever latency	2.5	3.5	3.6	1.9	-1.9	-1.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	-0.5	0.5	0.6
Pavlov. Cond. change in total contacts	0.9	2.1	2.2	-1.5	1.5	1.4
Pavlov. Cond. index score	2.0	3.1	3.2	-1.8	1.7	1.8
Pavlov. Cond. latency score	2.2	3.6	3.7	-1.9	1.9	1.9
Pavlov. Cond. lever contacts	1.3	1.9	1.9	-1.4	1.4	1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.7	0.8	0.8	-0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.3	2.4	-1.5	1.5	1.6
Pavlov. Cond. response bias	1.2	1.6	1.7	-1.3	1.3	1.3
Time in closed arm before self-admin	0.9	1.6	2.1	1.3	-1.5	-1.1
Time in closed arm after self-admin	0.9	1.0	1.5	-1.0	0.7	1.2
Time in open arm before self-admin	1.5	1.8	2.5	-1.3	1.6	1.1
Time in open arm after self-admin	1.0	1.1	1.2	1.1	-1.0	-1.1
Bone: periosteal estimation	0.4	0.9	0.9	-0.9	0.9	1.0
Bone: periosteal perimeter	0.3	0.6	0.7	-0.7	0.7	0.8
Bone: post-yield work	0.2	0.4	0.6	0.6	-0.8	-0.5
Progressive ratio test 1 active lever presses	0.3	0.6	0.8	-0.8	0.5	0.9
Progressive ratio test 1 breakpoint	0.4	0.7	0.9	-0.9	0.6	0.9
Progressive ratio test 1 inactive lever presses	0.9	2.4	2.9	-1.6	1.4	1.7
Progressive ratio test 2 active lever presses	0.2	0.3	0.4	-0.6	0.5	0.7
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	-0.6	0.4	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	-0.4	0.4	0.4
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	-0.1	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	-0.1	-0.2
Sum of active levers in priming session hrs 5-6	1.6	1.5	1.7	1.3	-1.1	-1.3
Progressive ratio	0.0	0.1	0.2	0.3	-0.1	-0.4
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	-0.2	-0.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.4	0.2	0.6
Retroperitoneal fat weight	0.5	2.0	2.1	1.5	-1.4	-1.4
Reaction time number correct	0.3	1.2	1.3	1.2	-1.0	-1.1
Reaction time mean minus median	0.0	0.3	0.3	0.6	-0.5	-0.6
Reaction time mean minus median AUC	0.3	2.3	2.6	1.5	-1.6	-1.4
Reaction time num false alarms	4.6	7.9	8.5	-2.8	2.9	2.7
Reaction time num false alarms AUC	3.5	8.1	8.9	-2.8	3.0	2.7
Reaction time trials correct on left	0.3	1.2	1.3	1.2	-1.0	-1.1
Reaction time trials on left	0.3	1.2	1.4	1.2	-1.0	-1.1
Reaction time mean	0.4	0.9	1.1	1.0	-0.9	-1.0
Reaction time mean AUC	0.3	0.7	0.8	0.9	-0.8	-0.8
Median of all reaction times	0.4	0.6	0.8	0.9	-0.7	-0.8
Reaction time omissions	1.1	1.8	2.1	1.3	-1.4	-1.2
Reaction time false alarm rate	5.9	8.2	8.5	-2.9	2.9	2.7
Reaction time premature initiation rate	0.1	0.2	0.2	0.4	-0.5	-0.4
Reaction time premature initiations	0.2	0.5	0.6	0.7	-0.7	-0.7
Std. dev. reaction times	0.4	1.2	1.2	1.1	-1.1	-1.1
Reaction time trials completed	0.3	1.2	1.4	1.2	-1.0	-1.1
Reaction time trials AUC	0.3	1.0	1.1	1.1	-0.9	-1.0
Run reversals in cocaine runway, females	0.0	0.1	0.1	0.3	0.2	-0.2
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.2	-0.5	-0.2
Latency to leave start box in cocaine runway	0.2	0.3	0.8	-0.4	0.9	0.2
Latency to leave start box in cocaine runway, F	0.0	0.1	0.2	-0.0	0.4	-0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.3	0.5	0.1
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.1	-0.1	0.0
Total sessions with >9 infusions	0.2	0.2	0.5	0.4	-0.7	-0.2
Short access day 1 total inactive lever presses	2.1	4.2	5.1	2.0	-2.3	-1.8
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.0	0.2
Short access day 1 total infusions	0.3	0.5	1.0	0.7	-1.0	-0.5
Short access day 10 total infusions	0.2	0.3	0.6	0.5	-0.8	-0.3
Short access total infusions	0.1	0.2	0.4	0.2	-0.6	0.0
Short access day 1 locomotion	0.0	0.1	0.1	-0.2	0.0	0.4
Short access day 10 total locomotion	0.2	0.6	0.7	-0.8	0.7	0.8
Short access total locomotion	0.4	0.6	0.8	-0.8	0.6	0.9
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.3	-0.1	0.3
Compulsive drug intake	0.8	1.1	1.3	1.0	-1.2	-1.0
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	0.2	0.4
Social response proportion	1.9	2.4	2.8	1.6	-1.7	-1.4
Social responses	2.0	2.6	2.6	1.6	-1.6	-1.6
Social time	1.3	2.1	3.2	1.3	-1.8	-1.1
Soleus weight	2.3	6.7	7.2	2.6	-2.7	-2.5
Bone: stiffness	1.6	2.9	3.1	1.7	-1.8	-1.7
Tibialis anterior weight	2.8	9.5	9.8	3.1	-3.1	-3.0
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.2	-0.3	-0.0
Time to tail flick, vehicle, after self-admin	0.3	0.5	0.6	-0.7	0.7	0.8
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	-0.2	-0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.4	0.6	0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.5	0.6	0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	0.5	-0.7	0.7	0.6
Tibia length	0.0	0.1	0.1	-0.3	0.2	0.3
Ambulatory time before self-admin	0.8	2.6	2.9	-1.6	1.5	1.7
Ambulatory time after self-admin	0.0	0.0	0.0	-0.0	0.0	0.0
Bone: tissue strength	1.8	1.9	1.9	-1.3	1.4	1.4
Total heroin consumption	3.8	4.5	5.7	2.2	-1.8	-2.4
Bone: trabecular number	2.7	5.2	5.3	2.3	-2.2	-2.3
Bone: trabecular spacing	0.3	0.4	0.4	-0.6	0.6	0.7
Bone: trabecular thickness	0.0	0.0	0.0	-0.0	0.1	0.1
Bone: trabecular tissue density	1.1	2.0	2.2	-1.4	1.5	1.4
Water consumed over 24 hours	0.0	0.1	0.1	-0.1	0.3	0.2
Number of responses in last shaping day	1.1	1.4	1.5	-1.2	1.2	1.2