Hub : Genes

Thrsp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Thrsp 0.1 0.07 8.1e-03 0.06 0.07 0.06 0.06 1.3e-02 5.8e-03 1.0e-02 7.9e-03
2 NAcc gene expression Thrsp 0.03 0.02 6.6e-04 0.02 0.03 0.02 0.02 1.3e-03 6.4e-04 1.5e-03 7.9e-04
3 PL gene expression Thrsp 0.16 0.09 1.1e-16 0.14 0.15 0.16 0.16 1.4e-15 1.6e-16 3.4e-17 6.9e-17
4 Brain gene expression Thrsp 0.22 0.09 0.0e+00 0.24 0.24 0.24 0.25 7.3e-22 6.5e-22 2.4e-22 8.7e-23
5 Liver gene expression Thrsp 0.06 0.04 1.7e-04 0.02 0.02 0.02 0.02 1.3e-03 1.6e-03 3.7e-03 2.5e-03
6 pVTA gene expression Thrsp 0.28 0.13 2.6e-08 0.2 0.19 0.18 0.18 2.9e-09 1.5e-08 3.7e-08 3.4e-08
7 BLA gene expression Thrsp 0.09 0.06 2.4e-04 0.08 0.07 0.07 0.07 3.0e-05 1.4e-04 1.3e-04 7.4e-05
8 Liver mRNA stability Thrsp 0.14 0.1 7.9e-06 0.06 0.04 0.05 0.05 8.4e-07 1.2e-05 5.0e-06 3.7e-06
9 Adipose gene expression Thrsp 0.3 0.12 0.0e+00 0.18 0.17 0.17 0.17 4.4e-19 2.6e-18 2.8e-18 5.5e-19
10 IL gene expression Thrsp 0.36 0.15 4.9e-05 0.09 0.11 0.12 0.11 3.0e-03 1.4e-03 8.7e-04 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.10.50.1-0.20.30.20.5-0.3-0.20.1-0.10.7
Area under the delay curve0.91.01.4-1.11.0-1.2-0.81.20.80.8-1.20.9-0.8
BMI with tail0.31.05.10.7-0.71.31.0-2.3-0.3-0.6-0.2-0.50.2
BMI without tail1.53.116.51.5-1.22.21.3-4.1-0.8-1.00.2-0.61.2
Body weight0.62.314.90.9-0.82.11.3-3.9-0.3-0.3-0.5-0.40.2
Weight adjusted by age0.60.61.8-0.50.7-0.4-0.4-0.71.00.90.11.1-1.4
Bone surface1.42.53.4-1.71.7-1.6-1.61.41.81.8-0.91.7-1.2
Bone volume0.91.52.3-1.41.4-1.0-1.31.01.41.4-1.11.5-0.7
Breakpoint value in progressive ratio session0.10.10.4-0.20.1-0.30.00.60.40.20.10.1-0.5
Number of licking bursts2.32.73.61.8-1.81.71.8-1.8-1.5-1.71.3-1.91.0
Context. condit. distance diff. score3.13.74.9-2.02.0-2.2-2.22.12.22.0-0.81.8-1.5
Locomotion velocity, session 10.50.52.4-0.60.5-0.9-0.61.60.30.4-0.40.4-0.6
Locomotion distance, session 10.40.51.3-0.60.7-1.2-0.90.90.60.5-0.10.2-1.0
Locomotion velocity, session 20.80.91.2-0.90.9-0.9-0.81.01.01.0-0.91.1-1.0
Locomotion distance, session 20.10.10.6-0.10.00.00.1-0.00.2-0.0-0.8-0.1-0.8
Locomotion velocity, session 30.30.30.5-0.60.5-0.7-0.60.70.40.5-0.50.6-0.1
Locomotion distance, session 32.02.13.7-1.51.5-1.9-1.51.91.31.4-0.91.4-0.9
Stereotopy head waving bouts, day 33.84.55.72.3-2.22.42.3-1.9-2.0-2.02.1-1.82.0
Stereotopy head waving duration, day 30.30.40.70.5-0.70.80.9-0.2-0.7-0.7-0.4-0.60.6
Locomotion velocity, session 70.40.41.3-0.60.6-0.6-0.50.80.70.5-0.30.6-1.2
Locomotion distance, session 71.21.63.6-1.31.3-1.3-1.20.71.51.3-0.51.2-1.9
Stereotopy head waving bouts, day 70.10.10.40.2-0.20.10.30.6-0.2-0.10.60.1-0.2
Stereotopy head waving duration, day 70.20.20.4-0.40.4-0.4-0.40.70.50.4-0.40.6-0.4
Locomotion velocity, session 86.88.112.1-3.12.8-2.7-2.63.52.82.7-2.72.7-2.7
Locomotion distance, session 81.62.43.3-1.61.6-1.6-1.61.71.81.5-1.21.4-1.5
Degree of sensitization distance0.30.32.40.3-0.10.50.1-1.50.2-0.00.3-0.2-0.5
Degree of sensitization stereotypy1.41.53.6-1.11.1-1.4-1.11.91.21.1-0.31.3-1.3
Conditioned locomotion0.10.10.7-0.1-0.1-0.10.10.4-0.0-0.2-0.8-0.20.3
Cocaine response after cond. corrected0.20.20.4-0.30.4-0.6-0.6-0.20.50.60.50.1-0.1
Cocaine response after cond. not corrected0.20.20.9-0.20.3-0.4-0.50.10.20.40.9-0.10.1
Cocaine response before conditioning0.60.71.80.9-0.80.70.70.2-0.9-1.01.3-0.90.7
Saline control response0.81.04.3-1.11.0-0.5-1.1-0.20.80.9-2.10.9-0.3
Bone: connectivity density0.20.42.2-0.40.4-0.6-0.41.50.30.30.30.40.1
Bone: cortical apparent density0.20.30.80.4-0.50.50.4-0.5-0.5-0.5-0.4-0.40.9
Bone: cortical area0.71.12.3-1.01.1-0.6-1.0-0.11.41.3-0.61.0-1.5
Bone: cortical porosity0.10.10.50.4-0.30.10.20.2-0.2-0.30.7-0.40.2
Bone: cortical porosity0.30.31.20.6-0.50.20.40.1-0.4-0.51.1-0.50.5
Bone: cortical thickness0.10.10.30.2-0.20.20.1-0.40.2-0.10.5-0.3-0.5
Bone: cortical thickness1.31.52.9-1.11.2-1.7-1.60.81.41.30.20.8-1.4
Bone: cortical tissue density0.20.31.00.5-0.50.50.4-0.5-0.5-0.6-0.3-0.51.0
Condit. Reinf. active minus inactive responses0.20.21.2-0.20.3-0.1-0.5-1.10.40.3-0.50.20.1
Condit. Reinf. active-inactive response ratio0.20.21.4-0.10.20.0-0.4-1.20.40.2-0.40.00.5
Condit. Reinf. active responses0.10.11.00.2-0.10.30.0-1.0-0.0-0.2-0.3-0.10.2
Condit. Reinf. inactive responses0.00.00.10.2-0.20.10.20.0-0.1-0.3-0.00.0-0.2
Incentive salience index mean0.30.40.6-0.60.7-0.5-0.8-0.40.70.7-0.60.7-0.4
Condit. Reinf. lever presses0.70.91.5-1.01.0-0.9-0.90.90.90.9-0.91.2-0.9
Condit. Reinf. active minus inactive responses4.65.87.5-2.62.7-2.3-2.70.62.62.6-2.32.4-2.4
Condit. Reinf. active-inactive response ratio3.13.33.8-1.91.9-1.9-1.90.91.91.8-1.71.7-2.0
Condit. Reinf. active responses5.37.49.2-2.93.0-2.5-3.00.33.03.0-2.72.8-2.8
Condit. Reinf. inactive responses0.91.11.7-1.01.1-0.5-1.1-0.71.21.2-1.31.2-1.0
Condit. Reinf. lever presses11.515.619.0-4.44.2-3.9-4.12.54.24.1-4.33.8-3.8
Condit. Reinf. lever reinforcers received6.08.410.8-3.13.2-2.7-3.30.63.23.2-2.73.0-2.9
Conditioned reinforcement - actives2.02.04.3-1.21.4-1.7-1.42.11.51.40.61.4-0.9
Conditioned reinforcement - inactives0.30.41.60.3-0.30.20.90.00.10.11.1-0.3-1.3
Conditioned locomotion1.31.64.6-1.11.2-1.4-1.02.11.11.30.61.3-0.9
Patch foraging indifference point 0 sec1.62.54.0-1.81.7-1.5-1.70.61.71.6-2.01.5-1.5
Patch foraging indifference point AUC0.20.20.5-0.40.5-0.5-0.5-0.00.50.4-0.30.5-0.7
Delay disc. indifference point, 0s delay0.40.40.9-0.50.6-0.8-0.50.10.70.70.30.8-0.9
Delay disc. indifference point, 16s delay0.70.72.6-0.90.6-0.9-0.71.30.40.3-1.60.4-0.3
Delay disc. indifference point, 2s delay0.70.81.7-0.90.9-1.0-0.50.91.01.0-0.31.0-1.3
Delay disc. indifference point, 24s delay0.20.21.4-0.30.2-0.2-0.20.50.00.0-1.2-0.0-0.0
Delay disc. indifference point, 4s delay1.71.72.7-1.41.4-1.2-1.10.61.51.5-1.11.5-1.6
Delay disc. indifference point, 8s delay1.21.32.0-1.21.1-1.2-1.21.40.90.9-1.40.9-0.4
Indifference point function ln k0.20.31.0-0.50.4-0.2-0.40.90.30.2-1.00.2-0.1
Indifference point function log k0.20.31.0-0.50.4-0.2-0.40.90.30.2-1.00.2-0.1
Patch foraging total patch changes 0 sec1.52.54.0-1.81.7-1.5-1.70.71.61.6-2.01.4-1.4
Patch foraging total patch changes 12 sec0.50.61.2-0.70.9-0.6-0.8-0.10.91.0-0.00.9-1.1
Patch foraging total patch changes 18 sec1.51.92.9-1.41.5-1.4-1.70.41.51.3-1.41.6-1.0
Patch foraging total patch changes 24 sec0.60.71.6-0.81.0-1.0-1.3-0.00.90.9-0.21.0-0.3
Patch foraging total patch changes 6 sec0.10.21.1-0.50.3-0.2-0.20.10.30.2-1.10.1-0.4
Patch foraging time to switch 0 sec3.35.16.72.6-2.52.32.5-1.4-2.2-2.32.6-2.41.5
Patch foraging water rate 0 sec2.33.74.9-2.12.1-2.2-2.11.41.92.0-1.82.0-1.4
Patch foraging water rate 12 sec1.72.66.0-1.91.7-1.6-1.61.41.31.5-2.51.6-0.9
Patch foraging water rate 18 sec1.31.83.6-1.51.4-1.3-1.30.51.31.5-1.91.3-0.7
Patch foraging water rate 24 sec1.21.73.9-1.41.2-1.2-0.91.71.01.2-2.01.1-1.0
Patch foraging water rate 6 sec0.60.92.1-1.00.9-1.0-0.91.40.50.7-1.30.8-0.3
Seeking ratio, delayed vs. immediate footshock0.10.21.20.3-0.20.20.3-0.1-0.2-0.01.1-0.3-0.0
Distance traveled before self-admin0.10.10.20.2-0.30.20.3-0.4-0.2-0.20.1-0.40.2
Distance traveled after self-admin1.21.42.21.2-1.31.01.3-0.5-1.4-1.50.7-1.51.0
Extensor digitorum longus weight0.20.71.9-0.70.6-0.1-0.3-0.81.10.8-1.40.5-1.3
Bone: elastic displacement0.20.20.50.4-0.50.20.7-0.1-0.5-0.50.3-0.7-0.3
Bone: elastic work0.20.30.80.3-0.5-0.10.60.9-0.4-0.60.2-0.8-0.2
Bone: endosteal estimation1.02.13.5-1.61.7-1.1-1.60.21.51.8-1.21.9-1.2
Bone: endosteal perimeter2.34.97.1-2.42.4-1.7-2.11.12.42.5-2.32.7-2.2
Epididymis fat weight0.92.110.61.3-1.01.61.3-3.3-0.3-0.21.8-0.50.5
Delta time in closed arm before/after self-admin1.31.37.1-1.11.0-0.5-1.3-0.30.70.7-2.70.70.1
Delta time in open arm before/after self-admin0.90.91.5-0.91.0-0.9-0.90.21.21.2-0.01.2-1.0
Diff in mean of infusions in LGA sessions2.22.44.01.6-1.72.02.0-1.4-1.5-1.50.5-1.61.2
Delay discount exponential model param0.80.91.41.0-0.91.10.9-1.2-0.8-0.81.2-0.80.7
Extinction: sum of active levers before priming0.40.40.6-0.60.6-0.5-0.6-0.10.70.7-0.70.7-0.4
Active lever presses in extinction session 60.30.30.8-0.20.3-0.9-0.30.70.40.30.60.2-0.5
Bone: final force0.20.30.8-0.60.6-0.4-0.50.70.60.6-0.20.3-0.9
Bone: final moment0.20.40.9-0.60.6-0.4-0.50.70.60.7-0.20.4-0.9
Food consumed during 24 hour testing period1.01.23.9-1.01.0-0.8-0.82.01.00.9-1.11.50.1
Glucose0.50.81.1-1.00.8-0.4-0.40.81.01.1-1.00.9-1.0
Heart weight1.21.72.8-1.41.4-1.7-1.60.81.31.3-1.01.1-1.0
Delay discount hyperbolic model param1.11.11.51.2-1.11.20.9-1.2-1.0-1.01.1-1.01.0
Intermittent access intake day 1-15 change1.81.84.4-1.31.2-1.3-0.81.71.21.3-0.81.2-2.1
Intermittent access intake escalation2.32.34.6-1.51.5-1.5-1.11.81.41.5-1.11.4-2.1
Intermittent access intake escalation 20.40.41.2-0.50.6-0.5-0.30.50.70.80.30.7-1.1
Intermitt. access day 1 inactive lever presses1.01.14.11.2-1.00.81.2-0.7-0.9-0.72.0-0.80.3
Intermitt. access day 15 inactive lever presses0.30.32.70.1-0.10.10.60.00.10.20.3-0.2-1.6
Intermitt. access escalation Index0.40.41.30.6-0.60.81.1-0.2-0.6-0.50.3-0.6-0.3
Intermittent access day 1 total infusions1.11.32.0-1.21.3-1.1-1.10.81.41.4-0.51.3-0.8
Intermittent access day 15 total infusions3.03.44.5-1.91.9-1.8-1.42.12.02.1-0.81.9-2.1
Intermittent access terminal intake (last 3 days)1.61.72.7-1.31.3-1.2-0.91.31.61.60.01.5-1.5
Intermittent access total infusions1.11.22.2-1.01.1-1.1-0.81.01.51.50.51.3-1.0
Intermittent access day 1 locomotion0.20.31.3-0.10.2-0.20.10.90.20.31.10.40.1
Intermittent access day 15 total locomotion1.21.31.8-1.21.2-1.1-1.01.21.21.3-0.21.3-1.2
Intermittent access total locomotion0.50.51.1-0.70.8-0.5-0.50.70.81.00.61.0-0.5
Intermittent access standard deviation0.20.20.90.10.0-0.10.3-0.20.30.40.90.2-0.7
Left kidney weight0.30.81.6-0.60.8-0.1-0.7-1.31.11.0-0.91.1-0.5
Right kidney weight0.10.32.2-0.10.20.2-0.2-1.50.50.4-0.70.4-0.1
Cocaine induced anxiety1.31.52.41.2-1.31.51.3-0.8-1.5-1.40.6-1.40.7
Post-drug Anxiety0.10.10.30.1-0.20.3-0.0-0.3-0.2-0.3-0.6-0.50.3
Baseline Anxiety2.72.94.2-1.81.8-1.9-2.11.31.81.7-1.71.6-1.0
Tail length0.41.38.9-0.10.40.7-0.4-3.00.60.7-0.81.00.1
Length with tail0.31.39.10.4-0.21.50.6-3.00.00.3-0.70.20.2
Length without tail0.10.20.60.2-0.40.70.8-0.2-0.3-0.2-0.5-0.6-0.1
Times rat made contact with spout0.91.12.51.0-1.01.61.1-1.1-0.9-0.80.5-0.61.3
Lifetime Intake1.31.52.4-1.21.3-1.3-1.11.11.51.50.31.3-1.1
Liver weight, left0.30.52.00.5-0.51.30.9-1.4-0.5-0.10.1-0.30.3
Liver weight, right3.35.612.12.4-2.23.22.6-3.5-1.8-1.62.2-1.71.5
Locomotor activity0.40.62.50.4-0.50.7-0.0-0.7-0.8-0.7-1.0-0.51.6
Locomotor testing distance0.40.72.6-0.70.8-0.5-1.4-0.50.50.6-1.60.70.1
Locomotor testing rearing0.30.43.20.10.00.6-0.3-1.80.0-0.0-0.50.1-0.1
Locomotion in novel chamber0.50.63.9-0.60.5-0.3-0.12.00.30.60.10.5-0.9
Locomotion in novel chamber post-restriction2.53.18.0-1.91.7-1.7-1.32.81.51.6-1.41.6-1.4
Fecal boli incidents, locomotor time 12.52.86.2-1.61.7-2.5-2.22.01.51.3-0.01.6-1.0
Change in fecal boli incidents, locomotor task2.01.93.31.3-1.51.81.6-0.9-1.6-1.5-0.1-1.61.2
Time >=10cm from walls, locomotor time 10.80.82.2-0.90.8-1.2-0.81.50.80.5-0.60.7-0.6
Bouts of movement, locomotor time 10.91.02.9-1.10.9-0.8-0.60.90.90.7-1.70.7-1.4
Total resting periods, locomotor time 10.70.82.4-0.90.7-0.6-0.41.20.60.6-1.60.5-1.2
Rest time, locomotor task time 10.50.61.9-0.80.6-0.5-0.51.40.30.4-1.10.3-0.8
Distance moved, locomotor task time 10.20.21.1-0.10.3-0.2-0.3-1.00.70.50.20.6-0.3
Vertical activity count, locomotor time 10.20.20.6-0.20.3-0.4-0.3-0.80.60.4-0.10.50.1
Time >=10cm from walls, locomotor time 20.80.81.4-1.01.1-1.0-1.00.60.91.0-0.41.2-0.6
Bouts of movement, locomotor time 20.10.10.7-0.20.2-0.00.0-0.10.40.3-0.30.3-0.8
Total resting periods, locomotor time 20.10.10.3-0.20.2-0.1-0.1-0.00.30.2-0.20.2-0.6
Rest time, locomotor task time 21.41.62.41.4-1.41.11.1-0.4-1.5-1.51.4-1.51.1
Distance moved, locomotor task time 21.92.24.1-1.51.7-1.1-1.50.21.92.0-0.42.0-1.1
Vertical activity count, locomotor time 21.11.22.2-1.01.2-0.9-1.1-0.31.51.5-0.41.5-0.8
Light reinforcement 11.52.73.61.8-1.71.61.5-1.9-1.7-1.51.7-1.71.2
Light reinforcement 20.40.51.50.7-0.60.60.6-0.3-0.8-0.51.2-0.80.3
Bone: marrow area0.81.72.8-1.41.5-0.9-1.50.11.31.6-1.11.7-1.1
Bone: maximum diameter1.93.55.2-2.02.0-1.4-1.70.62.22.2-1.72.0-2.3
Bone: maximum force0.50.91.9-1.00.9-0.8-0.81.41.10.9-0.70.7-1.2
Bone: maximum moment0.61.01.8-1.11.0-0.8-0.81.41.11.0-0.70.8-1.3
Mean time between licks in bursts1.62.34.3-1.41.7-1.1-1.5-0.22.01.9-0.62.1-1.5
Mean num. licks in bursts1.72.13.4-1.61.6-1.2-1.51.51.31.6-1.31.8-0.7
Cd content in liver0.30.30.80.5-0.40.60.4-0.9-0.4-0.40.4-0.50.7
Co content in liver1.61.82.9-1.31.5-1.2-1.40.41.51.5-1.11.7-1.4
Cu content in liver0.60.71.4-0.80.8-0.7-1.1-0.71.00.8-1.20.90.0
Fe content in liver0.60.71.3-0.70.8-1.1-0.90.41.20.90.50.8-1.0
K content in liver1.11.12.41.1-1.01.21.0-0.7-1.1-1.10.7-0.81.5
Mg content in liver0.10.10.5-0.10.1-0.0-0.30.0-0.10.1-0.30.20.7
Mn content in liver1.21.42.91.1-1.11.01.10.2-1.4-1.21.3-1.11.7
Na content in liver0.80.93.80.9-0.80.40.70.1-0.8-0.81.9-0.71.1
Rb content in liver1.11.34.5-1.21.1-0.7-1.10.31.11.1-2.11.1-0.6
Se content in liver3.03.77.52.0-2.01.51.6-0.8-1.9-2.02.3-1.92.7
Sr content in liver0.60.51.0-0.80.7-0.8-0.71.00.70.7-0.50.7-0.7
Zn content in liver1.61.82.9-1.41.5-1.4-1.70.31.51.5-1.21.4-0.8
Bone: minimum diameter0.50.91.3-0.81.0-0.3-1.0-0.71.11.1-0.71.1-1.1
Time in familiar zone, hab. session 10.00.00.1-0.10.2-0.0-0.00.30.10.20.00.30.1
Time in novel zone, hab. session 10.20.21.00.3-0.30.30.2-1.0-0.2-0.3-0.3-0.6-0.2
Total zone transitions, hab. session 10.40.51.10.5-0.80.70.80.3-1.0-0.9-0.4-1.00.1
Total locomotion distance, hab. session 15.37.612.43.0-2.83.02.7-3.5-2.4-2.62.9-2.61.7
Locomotion velocity, hab. session 14.97.010.72.9-2.72.72.6-3.3-2.3-2.53.0-2.51.6
Time in familiar zone, hab. session 20.90.92.1-1.00.9-0.6-0.70.51.20.9-1.41.3-0.7
Time in novel zone, hab. session 20.10.10.6-0.00.1-0.4-0.3-0.0-0.10.20.8-0.2-0.3
Total zone transitions, hab. session 20.20.20.9-0.1-0.1-0.10.20.3-0.2-0.3-0.9-0.5-0.9
Total locomotion distance, hab. session 22.63.58.52.0-1.81.81.7-2.9-1.5-1.81.7-1.90.7
Locomotion velocity, hab. session 22.83.79.52.1-1.92.01.9-3.1-1.5-1.81.5-2.00.8
Novel to familiar place preference ratio0.20.20.40.3-0.30.60.5-0.4-0.5-0.20.4-0.5-0.5
Novelty place preference0.10.10.30.0-0.10.50.3-0.2-0.30.10.1-0.3-0.6
Time in novel zone, NPP test0.10.11.0-0.30.20.20.10.0-0.00.3-0.30.0-1.0
Total zone transitions, NPP test0.40.51.4-0.60.4-0.9-0.41.10.40.2-0.90.0-1.2
Total locomotion distance, NPP test2.02.86.91.9-1.51.21.3-2.5-1.0-1.42.6-1.70.4
Locomotion velocity, NPP test2.94.19.52.3-1.91.51.7-2.8-1.3-1.73.1-2.00.8
Intraocular pressure4.46.28.9-2.72.5-2.5-2.13.02.42.3-2.22.4-2.8
Delta distance traveled before/after self-admin0.50.51.00.7-0.80.70.8-0.3-0.9-1.0-0.1-0.80.8
Delta ambulatory time before/after self-admin0.40.40.80.5-0.70.50.60.2-0.9-0.9-0.5-0.80.8
Parametrial fat weight1.22.35.71.4-1.41.91.4-2.4-1.6-1.30.5-1.51.1
Pavlov. Cond. lever latency0.91.21.81.1-1.11.11.2-0.9-1.3-1.10.7-1.30.6
Pavlov. Cond. magazine entry latency1.31.62.9-1.41.4-1.1-1.70.41.61.4-1.01.4-0.7
Pavlov. Cond. change in total contacts1.41.52.9-1.11.3-1.5-1.50.81.71.40.21.4-0.7
Pavlov. Cond. index score1.82.33.6-1.61.7-1.5-1.90.71.91.7-1.21.8-0.9
Pavlov. Cond. latency score1.62.03.4-1.41.6-1.3-1.70.61.81.6-0.91.7-1.0
Pavlov. Cond. lever contacts1.01.22.1-1.11.2-1.1-1.30.71.41.2-0.81.5-0.6
Pavlov. Cond. magazine entry number1.92.33.81.7-1.71.41.9-0.6-1.7-1.71.5-1.60.8
Pavlov. Cond. intertrial magazine entries1.01.21.61.2-1.11.01.0-0.8-1.3-1.21.1-1.01.3
Pavlov. Cond. lever-magazine prob. diff.1.51.93.0-1.41.5-1.3-1.70.71.71.5-1.01.7-0.6
Pavlov. Cond. response bias0.60.71.7-0.91.0-0.8-1.30.30.90.9-0.71.10.1
Pavlov. Cond. lever latency15.020.224.95.0-4.84.74.9-3.1-4.6-4.55.0-4.14.0
Pavlov. Cond. magazine entry latency6.17.19.7-3.02.8-3.1-3.02.52.52.5-2.82.2-2.1
Pavlov. Cond. change in total contacts8.812.115.2-3.93.8-3.5-3.82.23.53.6-3.83.2-3.2
Pavlov. Cond. index score12.616.220.2-4.54.3-4.3-4.53.04.04.1-4.23.7-3.5
Pavlov. Cond. latency score11.914.818.4-4.34.1-4.2-4.23.03.73.8-4.13.5-3.4
Pavlov. Cond. lever contacts13.618.624.6-4.84.6-4.4-4.62.84.44.4-5.04.0-3.8
Pavlov. Cond. magazine entry number13.316.220.04.5-4.34.54.4-3.5-4.0-4.03.8-3.83.4
Pavlov. Cond. intertrial magazine entries1.11.55.21.3-1.01.40.9-2.3-0.9-1.01.0-0.71.0
Pavlov. Cond. lever-magazine prob. diff.11.915.218.9-4.34.2-4.2-4.32.83.94.0-4.03.6-3.4
Pavlov. Cond. response bias15.120.525.3-5.04.9-4.8-5.03.14.64.6-4.74.3-4.0
Time in closed arm before self-admin0.20.21.5-0.0-0.1-0.30.11.2-0.1-0.20.2-0.2-0.2
Time in closed arm after self-admin0.50.53.2-0.60.4-0.6-0.61.80.0-0.1-1.00.1-0.1
Time in open arm before self-admin0.91.01.31.0-1.01.00.8-1.1-1.1-1.00.4-1.01.0
Time in open arm after self-admin0.20.21.30.2-0.10.50.2-1.10.10.10.30.10.1
Bone: periosteal estimation1.73.55.1-2.02.1-1.5-2.00.42.22.3-1.32.1-2.2
Bone: periosteal perimeter1.62.75.8-1.81.7-0.9-1.40.51.81.7-2.41.9-1.6
Bone: post-yield work0.00.00.4-0.0-0.00.00.10.60.1-0.1-0.1-0.1-0.1
Progressive ratio test 1 active lever presses0.10.10.60.4-0.30.30.40.1-0.2-0.30.8-0.30.2
Progressive ratio test 1 breakpoint0.30.31.10.5-0.40.50.40.1-0.4-0.41.1-0.40.6
Progressive ratio test 1 inactive lever presses0.10.10.3-0.00.1-0.3-0.00.00.20.20.60.1-0.5
Progressive ratio test 2 active lever presses2.42.64.8-1.51.7-1.6-1.20.62.22.1-0.11.9-2.0
Progressive ratio test 2 breakpoint1.71.93.7-1.21.4-1.3-0.90.41.91.80.11.6-1.8
Progressive ratio test 2 inactive lever presses1.11.23.3-0.91.1-1.1-0.70.51.41.30.31.0-1.8
Incentive Sensitization - Responses3.23.25.9-1.71.8-1.8-1.20.42.42.3-0.52.0-2.4
Incentive Sensitization - Breakpoint2.93.05.6-1.61.7-1.7-1.10.52.42.3-0.31.9-2.4
Sum of active levers in priming session hrs 5-60.30.30.60.6-0.60.50.7-0.8-0.4-0.40.3-0.40.3
Progressive ratio1.11.32.8-1.21.1-1.3-1.31.70.80.8-1.40.7-0.8
Food seeking constrained by brief footshock0.40.51.6-0.70.8-0.3-1.1-0.60.50.5-1.30.5-0.4
Seeking ratio, punishment vs. effort0.80.94.80.9-0.60.90.6-2.2-0.3-0.21.3-0.30.7
Retroperitoneal fat weight2.27.330.32.4-2.23.62.6-5.5-1.7-1.31.3-1.51.7
Reaction time number correct0.60.81.60.9-1.00.70.70.1-1.2-1.3-0.1-1.21.0
Reaction time mean minus median0.30.41.4-0.60.6-0.1-0.7-0.10.40.6-1.20.5-0.6
Reaction time mean minus median AUC0.20.31.2-0.60.5-0.1-0.50.30.20.5-1.10.4-0.4
Reaction time num false alarms0.40.60.90.8-0.80.80.7-1.0-0.7-0.80.4-0.70.7
Reaction time num false alarms AUC0.10.10.20.4-0.40.40.3-0.2-0.3-0.40.3-0.30.3
Reaction time trials correct on left0.60.81.60.9-1.00.70.70.1-1.2-1.3-0.1-1.21.0
Reaction time trials on left0.60.81.60.9-1.00.60.70.1-1.2-1.2-0.0-1.31.0
Reaction time mean0.30.41.30.6-0.50.60.4-1.2-0.4-0.30.7-0.8-0.1
Reaction time mean AUC0.20.30.80.5-0.50.50.5-0.9-0.5-0.30.7-0.80.0
Median of all reaction times0.40.61.70.8-0.70.50.6-1.0-0.6-0.51.3-1.00.1
Reaction time omissions0.20.30.7-0.40.5-0.4-0.5-0.60.50.5-0.5-0.0-0.8
Reaction time false alarm rate0.00.10.30.00.10.10.0-0.30.20.20.60.2-0.3
Reaction time premature initiation rate0.40.54.3-0.00.20.4-0.3-2.10.30.7-0.00.30.1
Reaction time premature initiations0.20.32.70.3-0.10.5-0.1-1.6-0.20.1-0.1-0.30.4
Std. dev. reaction times0.20.30.7-0.40.40.1-0.6-0.80.40.5-0.80.3-0.4
Reaction time trials completed0.60.81.60.9-1.00.60.70.1-1.2-1.2-0.0-1.31.0
Reaction time trials AUC0.50.71.40.8-0.90.60.6-0.1-1.1-1.2-0.1-1.21.0
Run reversals in cocaine runway, females0.60.62.3-0.50.6-0.0-0.6-1.50.80.7-1.20.6-0.1
Run reversals in cocaine runway, males1.81.73.2-1.41.2-1.4-0.91.61.01.0-1.81.1-1.4
Latency to leave start box in cocaine runway2.22.35.11.6-1.41.10.9-1.4-1.3-1.42.0-1.42.2
Latency to leave start box in cocaine runway, F1.21.33.81.2-0.90.70.4-1.4-0.8-0.92.0-0.91.5
Latency to leave start box in cocaine runway, M1.41.32.41.2-1.20.91.1-0.3-1.1-1.11.3-1.21.5
Std. dev. time between licks in bursts0.20.32.00.3-0.10.50.0-1.4-0.2-0.10.10.20.7
Total sessions with >9 infusions0.70.71.2-0.80.8-1.0-0.91.01.11.00.40.7-0.9
Short access day 1 total inactive lever presses0.30.30.8-0.60.6-0.6-0.40.50.60.80.10.5-0.9
Short access day 10 total inactive lever presses1.31.43.11.3-1.31.41.8-1.2-1.2-1.00.7-1.20.0
Short access day 1 total infusions1.11.22.0-1.01.2-1.2-1.30.61.41.30.51.0-0.9
Short access day 10 total infusions1.21.32.2-1.11.3-1.3-1.50.81.41.30.11.3-0.7
Short access total infusions0.60.61.1-0.60.8-0.9-1.00.51.00.90.70.7-0.5
Short access day 1 locomotion1.51.63.8-1.31.3-1.5-1.41.91.21.3-0.11.0-0.7
Short access day 10 total locomotion0.10.10.2-0.20.30.1-0.30.30.10.40.20.50.4
Short access total locomotion0.40.42.80.5-0.30.30.20.2-0.3-0.21.7-0.30.8
One hour access (0.3 mA shock)2.22.64.4-1.61.7-1.6-1.50.72.02.1-0.51.8-1.8
Compulsive drug intake0.10.10.40.3-0.20.10.1-0.2-0.1-0.20.6-0.30.2
One hour access (shock baseline)1.31.62.6-1.31.3-1.1-1.10.91.51.6-0.71.4-1.4
Social response proportion3.13.35.11.9-1.82.01.5-1.6-1.8-1.61.9-1.72.2
Social responses1.31.64.41.2-1.11.61.0-2.1-1.1-1.00.5-1.21.3
Social time2.73.56.61.9-1.81.61.3-1.4-2.2-1.81.8-2.02.6
Soleus weight0.10.43.00.3-0.20.70.4-1.70.1-0.1-0.5-0.0-0.2
Bone: stiffness0.00.00.1-0.10.00.10.00.30.20.20.0-0.2-0.2
Tibialis anterior weight0.10.31.00.1-0.10.40.5-1.00.2-0.0-0.4-0.2-1.0
Time to tail flick, vehicle, before self-admin0.40.41.20.6-0.60.70.5-1.1-0.5-0.7-0.0-0.50.6
Time to tail flick, vehicle, after self-admin1.61.82.5-1.51.4-1.6-1.61.51.10.8-1.61.3-0.6
Time to tail flick, test, before self-admin0.80.81.1-1.01.0-0.8-1.00.70.81.0-1.01.0-0.6
Time to tail flick, test, after self-admin1.41.42.8-1.31.4-1.3-1.70.41.01.1-1.41.3-0.5
Delta time to tail flick, vehicle, before/after SA2.22.24.9-1.61.5-1.8-1.62.21.21.1-1.01.3-1.0
Delta time to tail flick, test, before/after SA0.20.10.30.4-0.40.10.2-0.3-0.5-0.50.2-0.50.4
Tibia length0.51.42.7-1.21.2-1.3-1.21.51.01.2-0.41.0-1.6
Ambulatory time before self-admin0.00.00.1-0.10.0-0.10.20.30.10.1-0.0-0.1-0.2
Ambulatory time after self-admin0.80.81.50.8-1.00.71.20.2-1.1-1.20.2-1.20.8
Bone: tissue strength1.81.83.11.3-1.51.31.80.3-1.4-1.31.5-1.50.8
Total heroin consumption0.10.10.3-0.20.2-0.40.00.20.30.2-0.50.1-0.2
Bone: trabecular number0.20.40.80.5-0.60.60.60.6-0.7-0.60.4-0.60.9
Bone: trabecular spacing0.30.40.9-0.60.7-0.9-0.90.30.40.6-0.00.6-0.3
Bone: trabecular thickness0.30.32.6-0.40.30.0-0.1-0.30.50.2-1.60.2-0.2
Bone: trabecular tissue density1.52.14.91.3-1.41.81.4-2.2-1.3-1.4-0.0-1.41.1
Water consumed over 24 hours1.41.72.61.4-1.41.61.4-0.6-1.3-1.40.6-1.11.6
Number of responses in last shaping day0.50.63.30.5-0.10.00.0-1.40.00.11.8-0.1-0.2