Hub : Genes

Thop1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Thop1	0.05	0.04	9.3e-05	0.03	0.02	0.03	0.03	1.1e-04	1.0e-03	4.4e-04	3.8e-04
2	Adipose	gene expression	Thop1	0.05	0.04	2.2e-04	0.01	0.02	0.01	0.02	9.1e-03	1.9e-03	1.5e-02	6.1e-03
3	IL	mRNA stability	Thop1	0.15	0.11	5.5e-03	0.03	0.03	0.03	0.02	6.5e-02	7.4e-02	5.9e-02	9.9e-02
4	pVTA	gene expression	Thop1	0.05	0.04	8.1e-03	0.05	0.04	0.04	0.04	4.1e-03	9.0e-03	6.1e-03	9.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.6	1.3	1.1	0.5	-0.6	0.6
Area under the delay curve	2.0	2.2	2.6	-1.3	-1.4	-1.6	1.6
BMI with tail	6.7	21.8	22.9	-4.7	-4.8	-4.6	4.6
BMI without tail	2.5	5.1	6.6	-2.6	-2.5	-2.0	2.0
Body weight	1.2	4.9	5.2	-2.2	-2.3	-2.2	2.2
Weight adjusted by age	0.4	0.4	0.8	-0.9	-0.8	-0.2	0.3
Bone surface	1.0	1.7	4.7	2.2	1.3	-0.3	0.3
Bone volume	1.0	1.7	4.7	2.2	1.3	-0.3	0.3
Breakpoint value in progressive ratio session	5.3	5.8	6.8	2.2	2.3	2.6	-2.5
Number of licking bursts	0.1	0.1	0.4	-0.6	-0.4	0.0	0.0
Context. condit. distance diff. score	0.3	0.4	0.4	-0.6	-0.6	-0.6	0.6
Locomotion velocity, session 1	0.8	0.8	1.7	1.3	1.0	0.6	-0.6
Locomotion distance, session 1	0.2	0.3	0.9	0.9	0.6	-0.1	0.1
Locomotion velocity, session 2	3.8	4.5	7.0	2.6	2.3	1.6	-1.6
Locomotion distance, session 2	1.6	2.2	4.1	2.0	1.8	0.9	-0.9
Locomotion velocity, session 3	6.2	7.2	7.6	2.6	2.7	2.8	-2.8
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.0	0.2	-0.2
Stereotopy head waving bouts, day 3	4.8	5.7	6.4	2.5	2.5	2.2	-2.2
Stereotopy head waving duration, day 3	5.6	6.7	7.2	2.6	2.7	2.5	-2.5
Locomotion velocity, session 7	0.8	0.9	1.1	1.0	1.0	0.8	-0.8
Locomotion distance, session 7	0.1	0.1	0.3	-0.5	-0.4	-0.0	0.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.6	0.3	-0.2	0.2
Stereotopy head waving duration, day 7	0.3	0.4	1.0	1.0	0.8	0.1	-0.1
Locomotion velocity, session 8	0.7	0.8	2.0	1.4	1.1	0.3	-0.3
Locomotion distance, session 8	0.1	0.1	0.3	0.5	0.4	0.1	-0.1
Degree of sensitization distance	0.4	0.4	0.5	-0.6	-0.6	-0.7	0.7
Degree of sensitization stereotypy	1.6	1.8	2.6	-0.9	-1.1	-1.6	1.6
Conditioned locomotion	2.0	2.3	4.0	-2.0	-1.7	-1.1	1.1
Cocaine response after cond. corrected	5.5	6.2	8.4	-2.9	-2.7	-2.1	2.1
Cocaine response after cond. not corrected	6.0	6.6	9.0	-3.0	-2.8	-2.2	2.2
Cocaine response before conditioning	0.5	0.6	0.9	1.0	0.8	0.7	-0.7
Saline control response	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.1
Bone: connectivity density	0.3	0.5	0.8	0.5	-0.0	-0.9	0.9
Bone: cortical apparent density	1.0	1.3	1.4	-1.1	-1.1	-1.2	1.2
Bone: cortical area	0.5	0.8	1.5	-0.2	-0.5	-1.2	1.2
Bone: cortical porosity	0.6	0.7	1.0	1.0	0.9	0.7	-0.7
Bone: cortical porosity	0.1	0.1	0.3	0.6	0.4	-0.1	0.1
Bone: cortical thickness	1.1	1.8	2.5	-1.0	-1.2	-1.6	1.6
Bone: cortical thickness	0.0	0.1	0.1	-0.3	-0.1	0.2	-0.2
Bone: cortical tissue density	0.7	0.9	0.9	-0.9	-0.9	-1.0	1.0
Condit. Reinf. active minus inactive responses	4.1	4.6	4.9	2.1	2.2	2.1	-2.1
Condit. Reinf. active-inactive response ratio	2.1	2.3	2.8	1.2	1.4	1.7	-1.7
Condit. Reinf. active responses	3.6	4.4	5.5	2.3	2.3	1.9	-1.9
Condit. Reinf. inactive responses	0.8	1.0	1.8	1.3	1.2	0.6	-0.6
Incentive salience index mean	2.3	2.8	3.6	1.9	1.8	1.4	-1.4
Condit. Reinf. lever presses	0.2	0.3	0.8	0.9	0.6	-0.3	0.3
Condit. Reinf. active minus inactive responses	2.3	2.8	3.7	1.3	1.5	1.9	-1.9
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.4	-0.0	0.7	-0.6
Condit. Reinf. active responses	2.3	3.2	3.3	1.7	1.8	1.8	-1.8
Condit. Reinf. inactive responses	1.4	1.7	2.4	1.6	1.4	1.0	-1.1
Condit. Reinf. lever presses	2.4	3.2	4.1	1.4	1.6	2.0	-2.0
Condit. Reinf. lever reinforcers received	1.7	2.4	2.9	1.4	1.5	1.7	-1.7
Conditioned reinforcement - actives	2.5	2.5	2.9	1.5	1.7	1.6	-1.5
Conditioned reinforcement - inactives	0.7	0.8	1.4	-1.2	-0.9	-0.6	0.7
Conditioned locomotion	8.2	9.9	10.2	3.1	3.2	3.2	-3.1
Patch foraging indifference point 0 sec	0.2	0.3	0.4	-0.5	-0.4	-0.6	0.6
Patch foraging indifference point AUC	1.0	1.2	1.4	1.0	1.0	1.2	-1.2
Delay disc. indifference point, 0s delay	6.6	7.3	9.7	-2.0	-2.4	-3.1	3.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.4
Delay disc. indifference point, 2s delay	5.5	6.1	7.3	-2.1	-2.3	-2.7	2.7
Delay disc. indifference point, 24s delay	0.5	0.5	0.6	-0.7	-0.8	-0.7	0.7
Delay disc. indifference point, 4s delay	1.0	1.0	1.6	-0.6	-0.8	-1.3	1.2
Delay disc. indifference point, 8s delay	1.1	1.1	1.5	-1.2	-1.2	-0.9	0.9
Indifference point function ln k	0.2	0.3	0.3	-0.5	-0.6	-0.6	0.6
Indifference point function log k	0.2	0.3	0.3	-0.5	-0.6	-0.6	0.6
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.5	-0.4	-0.5	0.5
Patch foraging total patch changes 12 sec	0.4	0.5	1.0	-1.0	-0.8	-0.5	0.4
Patch foraging total patch changes 18 sec	0.9	1.2	1.3	0.9	1.2	1.2	-1.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.2	0.3	0.2	-0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	0.4	0.6	0.4	-0.4
Patch foraging time to switch 0 sec	1.6	2.5	3.5	-1.1	-1.3	-1.9	1.8
Patch foraging water rate 0 sec	0.1	0.1	0.3	-0.3	-0.1	0.5	-0.5
Patch foraging water rate 12 sec	1.0	1.5	2.7	-1.6	-1.5	-0.8	0.8
Patch foraging water rate 18 sec	0.4	0.5	0.7	-0.8	-0.3	0.8	-0.8
Patch foraging water rate 24 sec	0.7	1.0	2.6	-1.6	-1.1	0.1	-0.1
Patch foraging water rate 6 sec	0.4	0.6	1.2	-0.0	0.3	1.1	-1.1
Seeking ratio, delayed vs. immediate footshock	5.2	6.0	7.0	2.7	2.6	2.3	-2.3
Distance traveled before self-admin	0.2	0.2	0.3	-0.1	-0.4	-0.5	0.5
Distance traveled after self-admin	1.1	1.2	1.8	1.3	1.1	1.0	-1.0
Extensor digitorum longus weight	4.7	18.4	22.2	-4.7	-4.6	-3.9	3.9
Bone: elastic displacement	0.3	0.4	0.4	0.6	0.6	0.6	-0.6
Bone: elastic work	0.1	0.2	0.3	-0.1	-0.3	-0.6	0.6
Bone: endosteal estimation	0.2	0.4	0.7	-0.2	-0.4	-0.8	0.8
Bone: endosteal perimeter	0.3	0.7	1.6	1.2	1.0	0.4	-0.4
Epididymis fat weight	0.2	0.4	0.7	0.4	0.4	0.8	-0.8
Delta time in closed arm before/after self-admin	1.3	1.2	3.4	-1.8	-1.2	-0.2	0.1
Delta time in open arm before/after self-admin	1.3	1.2	1.6	-0.9	-1.0	-1.2	1.3
Diff in mean of infusions in LGA sessions	1.6	1.8	2.1	1.4	1.3	1.4	-1.2
Delay discount exponential model param	1.8	1.9	2.3	1.2	1.4	1.5	-1.5
Extinction: sum of active levers before priming	1.1	1.1	1.9	0.5	0.9	1.4	-1.3
Active lever presses in extinction session 6	3.3	3.2	4.0	2.0	1.9	1.7	-1.6
Bone: final force	1.1	1.8	2.8	-0.7	-1.1	-1.7	1.7
Bone: final moment	0.9	1.4	2.3	-0.6	-0.9	-1.5	1.5
Food consumed during 24 hour testing period	0.5	0.6	0.6	-0.8	-0.8	-0.8	0.8
Glucose	1.2	1.8	2.1	-1.4	-1.4	-1.3	1.3
Heart weight	0.4	0.5	0.8	0.5	0.5	0.9	-0.9
Delay discount hyperbolic model param	2.6	2.8	3.3	1.5	1.6	1.8	-1.8
Intermittent access intake day 1-15 change	6.7	6.7	7.8	2.2	2.6	2.8	-2.7
Intermittent access intake escalation	6.2	6.1	8.4	1.6	2.3	2.9	-2.8
Intermittent access intake escalation 2	7.7	7.7	10.1	2.1	2.6	3.2	-3.1
Intermitt. access day 1 inactive lever presses	0.4	0.5	0.8	0.5	0.5	0.9	-0.8
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.6	0.5	0.6	0.8	-0.7
Intermitt. access escalation Index	0.3	0.3	0.5	0.1	-0.1	-0.7	0.7
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.1	-0.2	-0.4	0.5
Intermittent access day 15 total infusions	1.6	1.8	2.4	0.9	1.4	1.5	-1.4
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.3	1.1	1.1	1.1	-1.0
Intermittent access total infusions	0.1	0.1	0.2	0.2	0.4	0.4	-0.3
Intermittent access day 1 locomotion	0.2	0.3	0.3	0.5	0.5	0.5	-0.4
Intermittent access day 15 total locomotion	3.4	3.7	4.2	1.8	1.9	2.0	-1.9
Intermittent access total locomotion	1.0	1.2	1.4	1.2	1.1	1.1	-0.9
Intermittent access standard deviation	3.0	3.2	4.1	1.5	1.8	2.0	-1.9
Left kidney weight	0.1	0.2	0.4	0.6	0.5	0.0	-0.0
Right kidney weight	1.5	4.3	5.0	2.2	2.1	2.0	-1.9
Cocaine induced anxiety	1.0	1.2	2.6	1.6	1.1	0.7	-0.7
Post-drug Anxiety	0.7	0.7	1.9	1.4	0.9	0.3	-0.4
Baseline Anxiety	0.0	0.0	0.1	-0.3	0.0	0.2	-0.2
Tail length	3.2	9.6	11.0	2.7	3.0	3.3	-3.3
Length with tail	2.1	7.6	8.4	2.9	2.8	2.7	-2.6
Length without tail	0.1	0.3	0.8	0.9	0.6	0.0	-0.0
Times rat made contact with spout	0.2	0.3	0.6	-0.8	-0.6	-0.3	0.2
Lifetime Intake	0.0	0.0	0.1	0.2	0.3	0.2	-0.0
Liver weight, left	2.6	4.1	5.0	-2.2	-2.2	-1.8	1.8
Liver weight, right	1.7	2.8	2.9	-1.5	-1.7	-1.7	1.7
Locomotor activity	3.7	5.9	8.5	2.9	2.7	2.0	-2.0
Locomotor testing distance	2.2	3.7	5.0	2.2	2.1	1.6	-1.7
Locomotor testing rearing	0.0	0.0	0.1	0.1	0.1	0.3	-0.3
Locomotion in novel chamber	0.4	0.5	0.8	0.4	0.5	0.8	-0.9
Locomotion in novel chamber post-restriction	0.7	0.9	0.9	0.9	0.9	0.9	-0.9
Fecal boli incidents, locomotor time 1	2.0	2.2	2.9	-1.7	-1.6	-1.3	1.3
Change in fecal boli incidents, locomotor task	0.5	0.5	1.0	1.0	0.8	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	-0.1	-0.3	-0.7	0.7
Bouts of movement, locomotor time 1	0.1	0.2	0.2	0.4	0.4	0.4	-0.4
Total resting periods, locomotor time 1	0.2	0.3	0.4	0.6	0.5	0.5	-0.4
Rest time, locomotor task time 1	0.2	0.2	0.4	0.7	0.5	0.3	-0.3
Distance moved, locomotor task time 1	0.3	0.4	0.7	-0.2	-0.4	-0.8	0.8
Vertical activity count, locomotor time 1	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.1
Time >=10cm from walls, locomotor time 2	1.2	1.2	1.7	-1.3	-1.2	-1.0	1.0
Bouts of movement, locomotor time 2	0.5	0.5	1.1	1.0	0.9	0.4	-0.4
Total resting periods, locomotor time 2	0.5	0.5	1.1	1.0	0.8	0.3	-0.4
Rest time, locomotor task time 2	0.6	0.7	1.2	1.1	0.9	0.6	-0.5
Distance moved, locomotor task time 2	0.8	1.0	1.4	-1.2	-1.1	-0.8	0.8
Vertical activity count, locomotor time 2	0.9	0.9	1.6	-1.3	-1.1	-0.6	0.7
Light reinforcement 1	5.7	10.3	11.2	3.2	3.3	3.1	-3.1
Light reinforcement 2	1.7	2.3	2.7	1.5	1.7	1.5	-1.4
Bone: marrow area	0.2	0.4	0.7	-0.2	-0.5	-0.8	0.8
Bone: maximum diameter	0.8	1.5	2.9	1.7	1.5	0.7	-0.7
Bone: maximum force	1.2	2.1	3.0	-0.9	-1.2	-1.7	1.7
Bone: maximum moment	1.0	1.7	2.5	-0.8	-1.0	-1.6	1.6
Mean time between licks in bursts	3.9	5.5	6.4	2.1	2.3	2.5	-2.5
Mean num. licks in bursts	0.0	0.0	0.0	0.0	-0.1	-0.2	0.1
Cd content in liver	0.2	0.2	0.2	-0.3	-0.4	-0.5	0.5
Co content in liver	0.6	0.7	0.9	0.6	0.7	0.9	-0.9
Cu content in liver	0.1	0.1	0.2	0.3	0.0	-0.5	0.5
Fe content in liver	0.0	0.0	0.1	-0.2	-0.0	0.2	-0.2
K content in liver	0.1	0.1	0.3	0.5	0.3	-0.2	0.2
Mg content in liver	0.1	0.1	0.4	0.6	0.3	-0.2	0.2
Mn content in liver	1.4	1.6	3.7	1.9	1.5	0.5	-0.5
Na content in liver	0.9	1.0	1.4	-0.7	-0.8	-1.2	1.2
Rb content in liver	0.3	0.4	0.8	-0.0	-0.3	-0.9	0.9
Se content in liver	0.2	0.2	0.3	0.5	0.5	0.4	-0.4
Sr content in liver	0.1	0.1	0.2	-0.5	-0.2	0.3	-0.3
Zn content in liver	1.9	2.1	3.5	0.6	1.0	1.9	-1.9
Bone: minimum diameter	0.1	0.1	0.2	0.4	0.2	-0.3	0.3
Time in familiar zone, hab. session 1	2.1	2.0	2.4	1.2	1.3	1.5	-1.5
Time in novel zone, hab. session 1	0.9	0.9	1.5	-0.5	-0.7	-1.2	1.2
Total zone transitions, hab. session 1	0.9	1.3	2.4	1.6	1.4	0.7	-0.7
Total locomotion distance, hab. session 1	1.3	1.9	4.0	2.0	1.6	0.6	-0.6
Locomotion velocity, hab. session 1	1.6	2.3	4.2	2.1	1.8	1.0	-1.0
Time in familiar zone, hab. session 2	6.2	6.4	8.0	2.1	2.3	2.8	-2.8
Time in novel zone, hab. session 2	4.5	4.5	5.9	-1.6	-1.9	-2.4	2.4
Total zone transitions, hab. session 2	0.3	0.4	0.8	0.2	-0.1	-0.9	0.9
Total locomotion distance, hab. session 2	0.8	1.1	2.0	1.4	1.2	0.7	-0.7
Locomotion velocity, hab. session 2	0.8	1.1	2.2	1.5	1.3	0.6	-0.6
Novel to familiar place preference ratio	3.5	3.6	5.1	-1.3	-1.7	-2.2	2.2
Novelty place preference	2.0	2.1	3.0	-0.9	-1.2	-1.7	1.7
Time in novel zone, NPP test	2.3	2.4	3.4	-1.0	-1.4	-1.8	1.8
Total zone transitions, NPP test	0.1	0.1	0.1	0.2	0.1	-0.4	0.4
Total locomotion distance, NPP test	0.1	0.1	0.2	0.3	0.1	-0.5	0.5
Locomotion velocity, NPP test	0.1	0.1	0.4	0.6	0.4	-0.2	0.2
Intraocular pressure	0.1	0.2	0.3	-0.6	-0.3	0.5	-0.5
Delta distance traveled before/after self-admin	1.6	1.7	1.8	1.4	1.4	1.3	-1.2
Delta ambulatory time before/after self-admin	1.8	1.9	2.4	1.5	1.5	1.3	-1.2
Parametrial fat weight	0.6	1.1	1.2	1.1	0.9	1.1	-1.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.5	-0.2	0.3	-0.3
Pavlov. Cond. magazine entry latency	2.6	3.4	3.7	1.7	1.8	1.9	-1.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	0.3	0.2	-0.2
Pavlov. Cond. index score	0.4	0.5	0.9	0.9	0.8	0.5	-0.5
Pavlov. Cond. latency score	0.4	0.6	1.1	1.1	0.9	0.4	-0.4
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.8	0.5	-0.1	0.1
Pavlov. Cond. magazine entry number	0.6	0.7	0.8	-0.8	-0.9	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.2	0.1	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	0.9	1.4	1.2	1.1	0.8	-0.8
Pavlov. Cond. response bias	1.0	1.2	1.3	1.1	1.2	1.1	-1.1
Pavlov. Cond. lever latency	1.0	1.3	1.4	-1.2	-1.2	-1.1	1.1
Pavlov. Cond. magazine entry latency	0.7	0.8	1.1	1.0	0.9	0.8	-0.8
Pavlov. Cond. change in total contacts	1.0	1.3	1.6	1.0	1.1	1.2	-1.3
Pavlov. Cond. index score	1.1	1.4	1.5	1.2	1.2	1.2	-1.2
Pavlov. Cond. latency score	1.0	1.3	1.5	1.2	1.2	1.1	-1.1
Pavlov. Cond. lever contacts	0.9	1.2	1.4	0.9	1.0	1.2	-1.2
Pavlov. Cond. magazine entry number	1.1	1.3	1.7	-1.3	-1.2	-1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.1	-1.1	-0.8	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.6	1.3	1.2	1.2	-1.2
Pavlov. Cond. response bias	2.1	2.8	3.3	1.5	1.6	1.8	-1.8
Time in closed arm before self-admin	0.8	0.9	1.7	-0.3	-0.7	-1.2	1.3
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.2
Time in open arm before self-admin	1.3	1.4	1.8	1.0	1.0	1.2	-1.3
Time in open arm after self-admin	0.6	0.7	0.8	-0.8	-0.9	-0.8	0.8
Bone: periosteal estimation	0.3	0.7	1.4	-0.0	-0.4	-1.2	1.2
Bone: periosteal perimeter	0.2	0.3	0.9	1.0	0.7	-0.1	0.1
Bone: post-yield work	0.7	0.9	1.0	-0.9	-0.9	-1.0	1.0
Progressive ratio test 1 active lever presses	0.1	0.2	0.2	-0.4	-0.4	-0.3	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.4	-0.5	-0.4	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.2	0.1	0.0	0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.2	0.4	0.6	-0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	0.5	0.6	0.6	-0.5
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.4	0.3	0.2	-0.1
Incentive Sensitization - Responses	0.3	0.3	0.6	0.2	0.4	0.7	-0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.6	0.3	0.5	0.8	-0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.2	-0.0	0.0	0.1
Progressive ratio	0.3	0.3	0.6	-0.8	-0.7	-0.2	0.2
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	0.3	0.2	-0.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.6	0.5	0.1	-0.1
Retroperitoneal fat weight	0.4	1.3	1.5	-1.2	-1.2	-1.1	1.1
Reaction time number correct	0.7	0.9	1.8	-1.3	-1.1	-0.6	0.6
Reaction time mean minus median	0.9	1.1	1.2	1.1	1.1	1.0	-1.0
Reaction time mean minus median AUC	0.2	0.2	0.7	0.8	0.5	-0.2	0.1
Reaction time num false alarms	0.1	0.1	0.3	-0.6	-0.3	-0.1	0.1
Reaction time num false alarms AUC	0.2	0.3	0.8	-0.9	-0.5	-0.1	0.1
Reaction time trials correct on left	0.7	0.9	1.8	-1.3	-1.1	-0.6	0.6
Reaction time trials on left	0.6	0.9	1.7	-1.3	-1.1	-0.6	0.6
Reaction time mean	0.1	0.1	0.3	0.6	0.2	-0.3	0.3
Reaction time mean AUC	0.1	0.1	0.2	0.5	0.2	-0.4	0.4
Median of all reaction times	0.3	0.4	0.7	0.1	-0.3	-0.8	0.9
Reaction time omissions	0.2	0.3	0.5	0.6	0.7	0.5	-0.5
Reaction time false alarm rate	0.0	0.0	0.0	-0.2	-0.0	-0.1	0.1
Reaction time premature initiation rate	1.0	1.3	1.7	0.9	1.0	1.3	-1.3
Reaction time premature initiations	0.5	0.6	1.2	0.2	0.4	1.1	-1.1
Std. dev. reaction times	0.3	0.4	0.8	0.9	0.7	0.4	-0.4
Reaction time trials completed	0.6	0.9	1.7	-1.3	-1.1	-0.6	0.6
Reaction time trials AUC	0.6	0.9	1.9	-1.4	-1.1	-0.5	0.5
Run reversals in cocaine runway, females	0.6	0.6	1.0	1.0	0.8	0.5	-0.6
Run reversals in cocaine runway, males	1.3	1.2	2.0	1.4	1.2	0.9	-0.9
Latency to leave start box in cocaine runway	1.3	1.4	2.7	1.7	1.4	0.7	-0.6
Latency to leave start box in cocaine runway, F	0.4	0.5	1.0	1.0	0.5	-0.5	0.6
Latency to leave start box in cocaine runway, M	3.0	2.9	4.1	1.2	1.5	2.0	-2.0
Std. dev. time between licks in bursts	1.0	1.1	2.0	1.4	1.2	0.7	-0.7
Total sessions with >9 infusions	0.1	0.1	0.4	0.6	0.2	-0.2	0.3
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	0.2	0.2	-0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.0	0.1	0.4	-0.5
Short access day 1 total infusions	0.2	0.2	0.5	0.7	0.5	0.0	0.1
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.1	0.0	0.1
Short access total infusions	0.1	0.1	0.1	0.3	0.1	-0.2	0.3
Short access day 1 locomotion	0.8	0.9	1.5	1.1	1.2	0.7	-0.5
Short access day 10 total locomotion	4.0	4.5	5.4	1.8	2.1	2.3	-2.2
Short access total locomotion	1.0	1.0	1.5	1.2	1.1	0.9	-0.7
One hour access (0.3 mA shock)	0.3	0.3	0.5	-0.7	-0.4	-0.5	0.7
Compulsive drug intake	0.9	0.9	1.1	-1.0	-0.9	-1.0	0.9
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	0.1	0.3	-0.1
Social response proportion	0.7	0.8	1.3	1.1	0.9	0.7	-0.7
Social responses	8.2	10.6	13.5	3.7	3.3	3.0	-3.0
Social time	0.7	0.9	1.1	-1.0	-1.0	-0.9	0.8
Soleus weight	9.0	26.3	27.6	-5.0	-5.3	-5.1	5.1
Bone: stiffness	3.1	4.8	6.0	-1.8	-2.0	-2.4	2.4
Tibialis anterior weight	1.0	3.3	3.6	-1.7	-1.9	-1.8	1.8
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.4	1.2	1.0	0.5	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	0.0	-0.1	0.5	-0.6
Time to tail flick, test, before self-admin	0.4	0.4	1.1	1.0	0.6	0.1	0.0
Time to tail flick, test, after self-admin	0.2	0.3	0.6	0.8	0.6	0.2	-0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.3	-1.1	-1.1	-0.3	0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.2	0.1	0.5	-0.6
Tibia length	1.0	2.7	3.1	1.5	1.6	1.8	-1.8
Ambulatory time before self-admin	0.1	0.2	0.2	-0.2	-0.4	-0.5	0.5
Ambulatory time after self-admin	0.6	0.7	1.2	1.1	0.8	0.7	-0.7
Bone: tissue strength	1.8	1.7	2.2	-1.1	-1.2	-1.5	1.5
Total heroin consumption	2.1	2.5	3.1	1.8	1.6	1.5	-1.4
Bone: trabecular number	0.9	1.5	3.2	1.8	1.4	0.7	-0.7
Bone: trabecular spacing	0.9	1.1	3.0	-1.7	-1.2	-0.1	0.1
Bone: trabecular thickness	0.8	1.0	2.5	1.6	0.8	-0.7	0.7
Bone: trabecular tissue density	2.3	3.3	4.7	-2.2	-1.9	-1.6	1.6
Water consumed over 24 hours	0.5	0.6	1.0	-0.3	-0.5	-1.0	1.0
Number of responses in last shaping day	0.3	0.3	0.6	0.8	0.5	0.4	-0.4