Hub : Genes

Tec

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Tec 0.02 0.03 8.7e-04 0.01 0.01 0.02 0.01 4.3e-03 6.0e-03 1.7e-03 5.8e-03
2 Brain gene expression Tec 0.03 0.03 1.5e-03 0.01 0.02 0.02 0.01 1.4e-02 7.1e-03 6.1e-03 1.5e-02
3 BLA gene expression Tec 0.07 0.07 2.7e-03 0.01 0 -0 0.01 6.9e-02 1.7e-01 4.0e-01 1.4e-01
4 pVTA gene expression Tec 0.04 0.04 1.2e-03 0.02 0.04 0.03 0.03 4.4e-03 7.5e-04 1.1e-03 1.1e-03
5 Liver mRNA stability Tec 0.04 0.05 2.0e-03 0.01 0.01 0.02 0.01 9.2e-03 8.3e-03 4.6e-03 9.0e-03
6 NAcc gene expression Tec 0.16 0.13 0.0e+00 0.12 0.13 0.12 0.13 2.2e-17 3.9e-19 2.0e-18 2.6e-19
7 PL gene expression Tec 0.08 0.08 2.2e-07 0.05 0.05 0.05 0.06 2.5e-06 1.9e-06 2.3e-06 1.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.91.52.1-1.11.41.41.2-1.01.11.5
Area under the delay curve1.21.31.7-1.31.11.11.2-1.21.21.0
BMI with tail0.92.93.4-1.41.81.61.8-1.81.71.8
BMI without tail0.20.60.7-0.60.80.80.8-0.60.80.8
Body weight0.00.10.20.10.30.20.3-0.30.20.4
Weight adjusted by age2.53.94.41.6-2.0-2.0-2.02.0-2.1-2.1
Bone surface1.32.43.5-1.91.71.71.5-1.21.31.5
Bone volume1.22.12.7-1.31.61.61.4-1.31.11.6
Breakpoint value in progressive ratio session0.30.30.4-0.50.60.60.6-0.60.60.6
Number of licking bursts3.35.46.3-2.32.32.32.3-2.52.32.2
Context. condit. distance diff. score0.60.84.4-2.10.30.30.3-0.50.2-0.5
Locomotion velocity, session 10.91.06.1-2.50.50.60.3-0.00.2-0.4
Locomotion distance, session 10.30.41.9-1.40.60.60.4-0.20.40.2
Locomotion velocity, session 20.10.10.50.70.10.10.10.00.10.5
Locomotion distance, session 20.20.20.60.20.50.40.5-0.30.40.8
Locomotion velocity, session 30.10.10.2-0.5-0.1-0.2-0.20.3-0.3-0.4
Locomotion distance, session 30.60.61.2-0.3-0.6-0.8-0.70.9-0.9-1.1
Stereotopy head waving bouts, day 30.70.81.1-0.81.01.00.9-0.70.91.0
Stereotopy head waving duration, day 30.30.41.0-1.00.60.60.5-0.40.40.4
Locomotion velocity, session 72.32.52.81.5-1.6-1.6-1.71.6-1.5-1.6
Locomotion distance, session 72.43.03.51.4-1.8-1.7-1.91.7-1.8-1.9
Stereotopy head waving bouts, day 70.30.40.50.4-0.6-0.7-0.60.6-0.6-0.7
Stereotopy head waving duration, day 70.40.50.9-0.1-0.6-0.7-0.70.7-0.7-1.0
Locomotion velocity, session 80.10.10.3-0.2-0.3-0.3-0.30.2-0.5-0.5
Locomotion distance, session 80.20.21.1-1.10.30.30.3-0.40.1-0.1
Degree of sensitization distance0.91.03.21.8-1.0-0.8-0.90.7-0.7-0.5
Degree of sensitization stereotypy0.10.10.3-0.4-0.2-0.3-0.20.2-0.3-0.5
Conditioned locomotion1.31.52.5-0.31.31.11.3-1.31.31.6
Cocaine response after cond. corrected0.10.10.5-0.70.20.20.2-0.10.2-0.0
Cocaine response after cond. not corrected0.30.41.1-1.00.60.60.6-0.60.50.4
Cocaine response before conditioning0.00.00.10.00.2-0.00.2-0.20.10.2
Saline control response0.81.05.72.40.00.00.1-0.20.31.1
Bone: connectivity density1.01.63.6-1.91.31.31.2-0.81.11.0
Bone: cortical apparent density0.91.26.82.6-0.6-0.6-0.50.5-0.40.4
Bone: cortical area0.60.93.71.9-0.7-0.7-0.70.8-0.6-0.0
Bone: cortical porosity0.00.00.10.4-0.2-0.2-0.10.1-0.0-0.1
Bone: cortical porosity0.00.00.10.10.10.10.2-0.20.40.2
Bone: cortical thickness0.61.04.82.2-0.7-0.7-0.70.8-0.5-0.0
Bone: cortical thickness1.92.34.1-2.01.51.51.5-1.31.51.2
Bone: cortical tissue density0.81.06.32.5-0.4-0.4-0.40.3-0.30.5
Condit. Reinf. active minus inactive responses0.00.00.1-0.3-0.1-0.1-0.20.2-0.2-0.3
Condit. Reinf. active-inactive response ratio0.20.20.3-0.20.40.50.5-0.60.60.5
Condit. Reinf. active responses0.10.10.3-0.50.40.30.3-0.10.40.2
Condit. Reinf. inactive responses0.20.20.3-0.40.50.40.5-0.30.50.5
Incentive salience index mean0.50.61.4-1.20.70.70.7-0.60.60.5
Condit. Reinf. lever presses2.63.64.2-2.11.91.91.9-1.91.71.8
Condit. Reinf. active minus inactive responses1.01.43.1-0.5-1.1-1.1-1.11.0-1.2-1.8
Condit. Reinf. active-inactive response ratio0.80.92.1-0.8-0.7-0.8-0.80.8-1.0-1.5
Condit. Reinf. active responses0.20.31.1-1.0-0.2-0.2-0.20.2-0.3-0.8
Condit. Reinf. inactive responses0.70.91.1-0.80.81.01.0-0.91.00.9
Condit. Reinf. lever presses1.41.94.1-2.01.31.51.3-1.21.31.0
Condit. Reinf. lever reinforcers received0.20.31.5-1.20.10.10.1-0.1-0.0-0.5
Conditioned reinforcement - actives1.52.53.1-1.81.61.61.6-1.61.51.4
Conditioned reinforcement - inactives0.20.20.5-0.6-0.3-0.3-0.30.3-0.5-0.7
Conditioned locomotion0.10.10.4-0.6-0.1-0.1-0.10.1-0.3-0.4
Patch foraging indifference point 0 sec0.81.42.0-0.41.11.31.2-1.31.31.4
Patch foraging indifference point AUC1.31.88.12.9-1.0-1.1-1.00.8-0.8-0.1
Delay disc. indifference point, 0s delay2.93.25.5-2.31.71.71.7-1.71.81.4
Delay disc. indifference point, 16s delay0.00.00.00.1-0.1-0.1-0.00.0-0.0-0.0
Delay disc. indifference point, 2s delay2.83.15.3-2.31.71.71.7-1.71.71.4
Delay disc. indifference point, 24s delay1.01.11.3-0.91.11.01.1-1.11.11.1
Delay disc. indifference point, 4s delay3.53.75.9-2.41.91.91.9-1.81.91.5
Delay disc. indifference point, 8s delay0.91.11.5-0.51.01.01.1-1.11.11.2
Indifference point function ln k0.50.91.9-1.40.91.00.9-0.80.90.7
Indifference point function log k0.50.91.9-1.40.91.00.9-0.80.90.7
Patch foraging total patch changes 0 sec0.30.61.00.10.60.80.8-0.80.91.0
Patch foraging total patch changes 12 sec1.21.67.52.7-1.0-0.7-0.90.8-0.7-0.0
Patch foraging total patch changes 18 sec0.20.30.60.60.30.50.4-0.40.50.8
Patch foraging total patch changes 24 sec0.10.20.60.7-0.5-0.3-0.40.3-0.3-0.2
Patch foraging total patch changes 6 sec0.71.16.82.6-0.3-0.1-0.2-0.10.00.8
Patch foraging time to switch 0 sec0.51.06.4-2.50.30.50.2-0.1-0.1-0.7
Patch foraging water rate 0 sec3.47.227.45.2-2.3-2.3-2.21.9-1.8-0.8
Patch foraging water rate 12 sec0.20.51.20.90.40.50.6-0.60.71.1
Patch foraging water rate 18 sec0.40.62.91.70.00.20.1-0.00.50.9
Patch foraging water rate 24 sec0.60.83.41.8-0.7-0.7-0.70.7-0.5-0.2
Patch foraging water rate 6 sec0.91.48.52.9-0.6-0.5-0.40.3-0.10.6
Seeking ratio, delayed vs. immediate footshock2.12.63.51.3-1.6-1.6-1.61.9-1.6-1.7
Distance traveled before self-admin0.00.00.00.0-0.0-0.0-0.0-0.0-0.0-0.0
Distance traveled after self-admin0.00.10.10.2-0.2-0.2-0.20.2-0.2-0.2
Extensor digitorum longus weight1.24.96.8-1.32.32.32.3-2.12.42.6
Bone: elastic displacement0.70.83.01.70.30.30.4-0.40.61.2
Bone: elastic work0.40.52.21.50.10.10.2-0.20.40.9
Bone: endosteal estimation0.71.62.2-1.51.41.41.2-1.11.11.2
Bone: endosteal perimeter0.10.31.1-1.10.50.50.3-0.20.10.2
Epididymis fat weight0.20.50.70.7-0.8-0.8-0.70.6-0.7-0.8
Delta time in closed arm before/after self-admin0.30.30.30.5-0.6-0.6-0.60.6-0.6-0.6
Delta time in open arm before/after self-admin0.50.50.60.6-0.7-0.7-0.70.8-0.7-0.7
Diff in mean of infusions in LGA sessions0.50.70.9-0.70.80.80.8-1.00.80.8
Delay discount exponential model param1.11.21.71.3-1.1-1.1-1.11.1-1.1-0.9
Extinction: sum of active levers before priming0.60.60.60.7-0.8-0.8-0.80.7-0.8-0.8
Active lever presses in extinction session 61.51.51.71.1-1.3-1.2-1.31.3-1.3-1.2
Bone: final force0.10.20.4-0.60.50.50.4-0.30.30.4
Bone: final moment0.00.00.20.50.10.1-0.00.1-0.00.3
Food consumed during 24 hour testing period0.20.21.3-1.10.20.20.1-0.3-0.1-0.2
Glucose0.71.11.7-0.51.01.21.0-1.11.01.3
Heart weight3.65.56.1-2.32.42.42.4-2.52.22.3
Delay discount hyperbolic model param1.31.42.11.5-1.2-1.1-1.21.2-1.2-1.0
Intermittent access intake day 1-15 change0.30.61.5-1.20.70.70.7-0.70.70.5
Intermittent access intake escalation0.30.71.6-1.30.80.80.8-0.80.80.6
Intermittent access intake escalation 20.00.00.2-0.4-0.0-0.0-0.0-0.1-0.0-0.2
Intermitt. access day 1 inactive lever presses0.20.61.4-0.5-0.7-0.7-0.70.7-0.9-1.2
Intermitt. access day 15 inactive lever presses0.81.62.01.0-1.2-1.2-1.21.4-1.3-1.3
Intermitt. access escalation Index0.50.71.00.6-0.9-0.9-0.90.8-0.9-1.0
Intermittent access day 1 total infusions0.40.60.90.4-0.8-0.8-0.80.8-0.9-0.9
Intermittent access day 15 total infusions0.00.00.1-0.3-0.1-0.1-0.1-0.0-0.1-0.3
Intermittent access terminal intake (last 3 days)0.00.00.1-0.2-0.2-0.2-0.20.1-0.2-0.3
Intermittent access total infusions0.00.00.0-0.2-0.0-0.0-0.0-0.0-0.0-0.2
Intermittent access day 1 locomotion0.60.71.20.2-0.9-0.9-0.90.7-1.1-1.1
Intermittent access day 15 total locomotion0.00.00.2-0.40.10.10.0-0.2-0.0-0.1
Intermittent access total locomotion0.10.10.4-0.60.10.10.1-0.3-0.0-0.1
Intermittent access standard deviation0.51.02.3-1.51.01.00.9-1.10.80.7
Left kidney weight0.62.73.2-1.51.71.61.7-1.81.71.6
Right kidney weight0.31.31.4-1.01.21.11.2-1.11.11.2
Cocaine induced anxiety0.00.00.0-0.20.20.20.2-0.20.20.2
Post-drug Anxiety3.23.45.7-2.41.81.81.8-1.71.81.5
Baseline Anxiety1.31.53.2-1.81.21.21.2-1.11.20.9
Tail length0.51.83.71.9-1.3-1.2-1.31.3-1.0-0.9
Length with tail0.31.52.51.6-1.2-1.3-1.21.1-1.1-1.0
Length without tail0.10.20.4-0.50.50.20.5-0.70.40.4
Times rat made contact with spout3.13.64.3-1.41.91.91.9-2.01.92.1
Lifetime Intake0.00.00.0-0.0-0.1-0.1-0.10.1-0.1-0.2
Liver weight, left0.20.30.5-0.70.40.50.6-0.50.50.3
Liver weight, right0.30.62.81.7-0.4-0.6-0.40.5-0.40.1
Locomotor activity0.30.42.31.50.1-0.20.1-0.30.10.7
Locomotor testing distance0.61.01.90.21.00.81.0-1.30.91.4
Locomotor testing rearing0.10.10.70.8-0.3-0.3-0.30.0-0.3-0.0
Locomotion in novel chamber0.00.00.1-0.10.10.10.1-0.20.10.1
Locomotion in novel chamber post-restriction0.10.10.20.3-0.4-0.4-0.40.4-0.4-0.4
Fecal boli incidents, locomotor time 10.00.00.1-0.10.20.20.2-0.20.20.3
Change in fecal boli incidents, locomotor task0.00.00.0-0.0-0.1-0.1-0.10.1-0.1-0.2
Time >=10cm from walls, locomotor time 11.81.92.21.1-1.4-1.4-1.41.4-1.4-1.5
Bouts of movement, locomotor time 12.73.13.81.3-1.8-1.8-1.81.7-1.8-1.9
Total resting periods, locomotor time 13.03.33.71.6-1.9-1.9-1.91.8-1.9-1.9
Rest time, locomotor task time 11.62.05.72.4-1.3-1.3-1.31.2-1.3-0.7
Distance moved, locomotor task time 11.01.53.2-1.81.11.11.1-1.21.20.8
Vertical activity count, locomotor time 10.61.43.6-1.91.11.11.1-1.11.10.6
Time >=10cm from walls, locomotor time 20.60.91.40.5-1.0-1.0-1.01.0-1.0-1.2
Bouts of movement, locomotor time 20.10.10.2-0.2-0.3-0.3-0.30.3-0.3-0.4
Total resting periods, locomotor time 20.10.20.30.1-0.5-0.4-0.50.5-0.5-0.6
Rest time, locomotor task time 20.40.51.01.0-0.7-0.7-0.70.7-0.7-0.5
Distance moved, locomotor task time 20.91.11.3-1.11.01.01.0-1.01.00.9
Vertical activity count, locomotor time 20.30.40.4-0.50.60.60.6-0.60.60.6
Light reinforcement 10.40.92.6-1.60.80.90.8-0.90.80.4
Light reinforcement 20.10.10.5-0.70.20.30.2-0.20.00.0
Bone: marrow area0.81.82.6-1.61.41.41.3-1.11.11.3
Bone: maximum diameter0.30.52.71.6-0.3-0.3-0.40.6-0.30.4
Bone: maximum force0.10.20.3-0.20.50.50.4-0.30.40.6
Bone: maximum moment0.10.21.01.0-0.0-0.0-0.10.1-0.00.5
Mean time between licks in bursts0.10.20.9-0.9-0.0-0.0-0.00.2-0.1-0.4
Mean num. licks in bursts0.91.42.41.5-1.1-1.1-1.11.2-1.1-0.8
Cd content in liver0.80.95.5-2.30.30.40.3-0.20.1-0.6
Co content in liver0.30.30.9-0.4-0.6-0.5-0.50.4-0.6-1.0
Cu content in liver0.00.00.1-0.20.20.00.3-0.30.20.2
Fe content in liver0.40.52.0-1.40.60.50.5-0.40.50.1
K content in liver0.10.10.2-0.2-0.3-0.3-0.30.4-0.3-0.5
Mg content in liver3.83.94.32.0-1.9-1.9-2.02.1-2.1-1.8
Mn content in liver6.97.710.23.2-2.7-2.9-2.72.6-2.8-2.5
Na content in liver0.00.00.00.2-0.1-0.2-0.10.2-0.2-0.1
Rb content in liver0.30.40.60.5-0.6-0.5-0.70.8-0.5-0.6
Se content in liver7.38.611.33.4-2.9-3.1-2.92.8-2.8-2.6
Sr content in liver2.82.44.8-2.21.51.51.5-1.51.31.1
Zn content in liver0.20.20.5-0.3-0.4-0.4-0.40.3-0.4-0.7
Bone: minimum diameter0.10.10.50.70.10.1-0.00.10.00.4
Time in familiar zone, hab. session 10.10.10.2-0.2-0.1-0.1-0.30.3-0.4-0.3
Time in novel zone, hab. session 10.90.92.5-1.60.80.80.9-1.00.70.4
Total zone transitions, hab. session 10.10.10.6-0.80.2-0.00.00.1-0.3-0.2
Total locomotion distance, hab. session 10.00.00.10.30.20.00.1-0.20.10.3
Locomotion velocity, hab. session 10.00.00.1-0.20.20.10.2-0.20.10.2
Time in familiar zone, hab. session 20.60.63.92.0-0.2-0.2-0.2-0.00.00.6
Time in novel zone, hab. session 20.70.74.3-2.10.20.30.10.10.0-0.6
Total zone transitions, hab. session 20.00.00.1-0.30.0-0.1-0.10.2-0.1-0.1
Total locomotion distance, hab. session 20.00.10.30.6-0.1-0.2-0.10.2-0.10.1
Locomotion velocity, hab. session 20.00.10.20.50.10.10.1-0.10.10.4
Novel to familiar place preference ratio0.40.51.81.4-0.6-0.7-0.60.5-0.1-0.3
Novelty place preference0.20.30.80.9-0.5-0.5-0.50.4-0.1-0.3
Time in novel zone, NPP test0.50.61.21.1-0.8-0.8-0.70.7-0.3-0.6
Total zone transitions, NPP test0.81.11.81.3-0.9-1.1-1.01.0-1.1-0.8
Total locomotion distance, NPP test0.10.10.80.90.0-0.20.0-0.10.00.3
Locomotion velocity, NPP test0.20.20.50.30.40.30.5-0.50.50.7
Intraocular pressure1.42.02.80.8-1.5-1.5-1.51.3-1.5-1.7
Delta distance traveled before/after self-admin0.10.10.10.3-0.3-0.3-0.30.3-0.3-0.3
Delta ambulatory time before/after self-admin0.81.01.10.9-1.0-1.0-1.01.0-1.0-1.0
Parametrial fat weight0.00.10.5-0.70.00.1-0.10.3-0.1-0.2
Pavlov. Cond. lever latency0.60.81.30.1-0.8-0.9-0.91.0-0.9-1.1
Pavlov. Cond. magazine entry latency2.12.73.01.7-1.7-1.5-1.71.5-1.7-1.5
Pavlov. Cond. change in total contacts0.50.51.11.0-0.7-0.6-0.60.5-0.7-0.5
Pavlov. Cond. index score0.10.10.80.9-0.3-0.2-0.20.0-0.2-0.0
Pavlov. Cond. latency score0.10.10.40.6-0.2-0.1-0.1-0.1-0.10.1
Pavlov. Cond. lever contacts0.30.40.70.00.50.60.6-0.70.60.8
Pavlov. Cond. magazine entry number1.11.31.6-1.01.21.21.2-1.01.31.2
Pavlov. Cond. intertrial magazine entries0.40.52.1-1.50.60.50.4-0.20.40.1
Pavlov. Cond. lever-magazine prob. diff.0.20.31.51.2-0.4-0.3-0.30.1-0.3-0.0
Pavlov. Cond. response bias0.10.20.30.5-0.5-0.4-0.40.2-0.5-0.4
Pavlov. Cond. lever latency0.10.20.70.8-0.3-0.4-0.40.4-0.1-0.1
Pavlov. Cond. magazine entry latency1.72.04.8-2.21.31.41.4-1.21.10.9
Pavlov. Cond. change in total contacts0.00.10.4-0.60.10.30.2-0.00.1-0.1
Pavlov. Cond. index score1.21.64.1-2.01.11.31.2-1.11.00.8
Pavlov. Cond. latency score1.62.14.6-2.11.31.51.4-1.31.21.0
Pavlov. Cond. lever contacts0.20.30.9-0.90.40.50.5-0.40.20.2
Pavlov. Cond. magazine entry number1.51.84.32.1-1.3-1.4-1.31.1-1.1-0.9
Pavlov. Cond. intertrial magazine entries0.40.71.41.2-0.8-0.7-0.80.7-0.6-0.6
Pavlov. Cond. lever-magazine prob. diff.1.72.34.9-2.21.41.61.5-1.31.21.0
Pavlov. Cond. response bias0.10.20.9-1.00.20.30.3-0.2-0.0-0.1
Time in closed arm before self-admin0.00.00.00.1-0.1-0.1-0.1-0.0-0.1-0.1
Time in closed arm after self-admin0.00.00.00.1-0.1-0.1-0.1-0.0-0.1-0.1
Time in open arm before self-admin0.00.00.0-0.10.10.10.10.00.10.1
Time in open arm after self-admin0.30.30.50.5-0.5-0.5-0.50.7-0.5-0.5
Bone: periosteal estimation0.20.40.9-0.10.70.70.5-0.40.50.9
Bone: periosteal perimeter0.30.51.0-0.7-0.5-0.5-0.70.7-0.9-1.0
Bone: post-yield work0.00.00.10.2-0.0-0.0-0.10.2-0.30.0
Progressive ratio test 1 active lever presses0.20.20.30.3-0.5-0.5-0.50.6-0.5-0.5
Progressive ratio test 1 breakpoint0.10.10.20.3-0.3-0.3-0.30.4-0.3-0.3
Progressive ratio test 1 inactive lever presses0.10.10.5-0.70.00.00.00.4-0.1-0.2
Progressive ratio test 2 active lever presses0.00.00.2-0.5-0.0-0.0-0.0-0.0-0.0-0.2
Progressive ratio test 2 breakpoint0.00.00.2-0.4-0.1-0.1-0.10.1-0.1-0.3
Progressive ratio test 2 inactive lever presses0.10.20.4-0.4-0.3-0.3-0.30.4-0.4-0.6
Incentive Sensitization - Responses0.20.30.7-0.3-0.5-0.5-0.50.3-0.6-0.8
Incentive Sensitization - Breakpoint0.30.40.9-0.3-0.6-0.6-0.60.4-0.7-0.9
Sum of active levers in priming session hrs 5-61.21.11.21.0-1.1-1.0-1.11.1-1.1-1.0
Progressive ratio0.30.41.41.2-0.5-0.5-0.50.7-0.5-0.2
Food seeking constrained by brief footshock0.30.40.50.5-0.7-0.6-0.70.7-0.7-0.7
Seeking ratio, punishment vs. effort0.40.62.3-1.50.60.60.6-0.70.60.2
Retroperitoneal fat weight0.83.55.02.2-1.9-1.8-1.91.8-1.8-1.6
Reaction time number correct0.51.03.0-1.70.90.90.9-0.90.80.4
Reaction time mean minus median0.40.91.60.1-1.0-0.8-0.91.3-0.9-1.3
Reaction time mean minus median AUC0.71.83.8-0.5-1.2-1.2-1.21.5-1.3-2.0
Reaction time num false alarms0.81.12.9-1.70.91.00.9-0.90.90.5
Reaction time num false alarms AUC2.03.15.0-2.21.71.81.7-1.71.71.4
Reaction time trials correct on left0.51.03.0-1.70.90.90.9-0.90.80.4
Reaction time trials on left0.50.92.9-1.70.80.90.9-0.80.80.4
Reaction time mean0.50.91.31.0-0.9-0.9-0.91.1-0.8-0.8
Reaction time mean AUC0.91.42.01.0-1.2-1.2-1.21.4-1.1-1.2
Median of all reaction times0.91.32.71.6-1.1-1.1-1.11.2-1.0-0.8
Reaction time omissions1.42.13.40.3-1.5-1.3-1.41.7-1.5-1.8
Reaction time false alarm rate1.01.31.9-1.41.11.21.1-1.11.11.0
Reaction time premature initiation rate1.42.02.7-1.51.41.31.4-1.61.21.3
Reaction time premature initiations1.42.53.7-1.91.61.51.6-1.81.41.3
Std. dev. reaction times0.20.40.8-0.1-0.6-0.5-0.60.9-0.5-0.9
Reaction time trials completed0.50.92.9-1.70.80.90.9-0.80.80.4
Reaction time trials AUC0.50.92.7-1.70.80.90.9-0.90.80.4
Run reversals in cocaine runway, females0.30.30.4-0.60.50.50.5-0.60.40.4
Run reversals in cocaine runway, males0.00.00.0-0.10.10.10.1-0.10.10.1
Latency to leave start box in cocaine runway0.20.20.40.1-0.5-0.5-0.50.4-0.6-0.6
Latency to leave start box in cocaine runway, F0.00.10.3-0.50.00.0-0.1-0.1-0.1-0.2
Latency to leave start box in cocaine runway, M0.50.40.50.6-0.7-0.6-0.60.7-0.7-0.6
Std. dev. time between licks in bursts0.20.20.60.8-0.5-0.5-0.50.4-0.3-0.3
Total sessions with >9 infusions0.30.30.5-0.1-0.5-0.5-0.50.6-0.7-0.7
Short access day 1 total inactive lever presses0.10.10.6-0.80.20.20.2-0.00.2-0.0
Short access day 10 total inactive lever presses0.00.00.3-0.50.10.10.1-0.00.1-0.1
Short access day 1 total infusions0.81.11.51.2-1.1-1.1-1.11.0-1.0-0.9
Short access day 10 total infusions0.40.60.80.9-0.8-0.7-0.70.7-0.7-0.6
Short access total infusions0.40.50.60.8-0.7-0.7-0.70.7-0.7-0.6
Short access day 1 locomotion2.43.03.81.2-1.7-1.7-1.71.8-1.9-1.9
Short access day 10 total locomotion0.20.40.8-0.4-0.5-0.5-0.50.2-0.7-0.9
Short access total locomotion0.81.01.50.5-1.0-1.0-1.00.9-1.2-1.1
One hour access (0.3 mA shock)2.02.33.6-1.91.51.51.5-1.41.51.3
Compulsive drug intake0.00.00.0-0.1-0.0-0.0-0.1-0.0-0.1-0.1
One hour access (shock baseline)0.20.40.6-0.70.60.60.6-0.50.70.5
Social response proportion3.43.914.9-3.91.71.81.5-1.51.20.6
Social responses0.20.21.2-1.10.10.1-0.0-0.1-0.2-0.4
Social time3.24.38.9-3.02.02.11.9-1.71.91.5
Soleus weight0.20.63.92.0-0.1-0.2-0.00.10.20.7
Bone: stiffness0.00.00.00.1-0.2-0.2-0.20.2-0.2-0.2
Tibialis anterior weight0.30.91.2-1.11.00.91.0-0.71.00.9
Time to tail flick, vehicle, before self-admin0.00.00.00.1-0.1-0.1-0.10.1-0.1-0.1
Time to tail flick, vehicle, after self-admin1.11.51.71.2-1.3-1.3-1.31.0-1.3-1.3
Time to tail flick, test, before self-admin6.66.87.32.4-2.6-2.6-2.62.7-2.7-2.6
Time to tail flick, test, after self-admin0.00.00.00.2-0.2-0.2-0.20.2-0.2-0.2
Delta time to tail flick, vehicle, before/after SA0.70.70.70.8-0.9-0.9-0.90.6-0.9-0.9
Delta time to tail flick, test, before/after SA2.02.12.5-1.31.41.41.4-1.61.41.4
Tibia length0.10.20.30.5-0.4-0.4-0.40.4-0.5-0.3
Ambulatory time before self-admin0.10.10.1-0.30.30.30.3-0.40.30.3
Ambulatory time after self-admin0.10.10.10.3-0.4-0.4-0.40.3-0.4-0.4
Bone: tissue strength1.11.14.52.1-0.8-0.8-0.80.8-0.7-0.2
Total heroin consumption0.30.30.50.5-0.6-0.5-0.60.7-0.6-0.5
Bone: trabecular number0.71.22.4-1.51.21.11.0-0.70.90.9
Bone: trabecular spacing1.52.07.52.7-1.3-1.2-1.11.0-0.8-0.5
Bone: trabecular thickness2.53.17.9-2.81.71.71.6-1.61.31.1
Bone: trabecular tissue density0.20.31.01.0-0.5-0.5-0.40.2-0.4-0.2
Water consumed over 24 hours0.50.72.8-1.70.70.70.7-0.80.50.2
Number of responses in last shaping day1.51.64.82.2-1.2-1.1-1.11.2-1.0-0.6