Tead1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	NM_001198589.2	0.49	0.23	4.6e-03	0.01	0.01	0.02	0.01	9.3e-03	1.6e-02	1.6e-03	1.2e-02
2	Brain	isoform ratio	XM_006230052.3	0.03	0.02	5.5e-03	0.01	0.01	0.01	0	4.9e-02	4.4e-02	5.0e-02	1.3e-01
3	Brain	intron excision ratio	chr1_166963216_166963999	0.04	0.03	1.8e-03	0.02	0	0.01	0.01	1.1e-02	2.0e-01	8.4e-02	6.7e-02
4	Brain	isoform ratio	XM_039082778.1	0.02	0.02	8.2e-03	0.03	0.02	0.02	0.03	1.1e-03	5.8e-03	3.3e-03	2.2e-03
5	Liver	mRNA stability	Tead1	0.03	0.02	3.8e-03	0	0.01	0.01	0	1.2e-01	3.8e-02	6.9e-02	1.4e-01
6	IL	isoform ratio	XM_039082774.1	0.2	0.14	8.0e-03	0.1	0.1	0.04	0.1	1.8e-03	1.9e-03	4.3e-02	2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	1.2	-1.1	-0.6	0.5	-0.5	0.5	0.1
Area under the delay curve	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1	0.1	-0.1
BMI with tail	1.5	4.8	7.6	-2.8	2.5	-2.5	2.6	-1.1	-0.3
BMI without tail	1.4	2.9	4.9	-1.9	1.9	-2.1	2.2	-0.3	-1.0
Body weight	0.2	0.7	1.4	-0.9	0.7	-0.8	1.2	0.4	-1.0
Weight adjusted by age	1.5	1.7	5.3	1.2	0.2	0.2	-0.2	-1.8	2.3
Bone surface	0.1	0.2	1.0	-1.0	-0.3	0.3	-0.3	0.1	0.3
Bone volume	0.1	0.2	0.8	-0.9	0.1	-0.2	0.2	-0.2	0.4
Breakpoint value in progressive ratio session	1.9	2.1	12.2	-3.5	-0.1	-0.1	-0.4	0.0	-0.0
Number of licking bursts	0.5	0.6	1.8	0.6	0.3	-0.1	0.1	-1.1	1.3
Context. condit. distance diff. score	0.4	0.5	0.8	-0.7	0.7	-0.6	0.6	-0.8	0.9
Locomotion velocity, session 1	0.7	0.8	1.1	-0.9	1.0	-1.0	1.0	-0.8	0.5
Locomotion distance, session 1	2.7	3.5	5.1	-1.5	2.3	-2.0	2.0	-2.0	1.2
Locomotion velocity, session 2	0.4	0.4	0.8	-0.2	0.9	-0.9	0.9	-0.4	-0.0
Locomotion distance, session 2	3.1	4.3	7.6	-0.8	2.8	-2.5	2.5	-2.0	0.8
Locomotion velocity, session 3	0.1	0.1	0.3	0.4	0.0	0.2	-0.2	-0.5	0.5
Locomotion distance, session 3	0.3	0.4	0.7	0.9	-0.4	0.7	-0.7	-0.3	0.5
Stereotopy head waving bouts, day 3	1.2	1.4	3.5	0.7	0.9	-0.5	0.5	-1.9	1.7
Stereotopy head waving duration, day 3	0.4	0.5	1.2	-0.1	0.7	-0.5	0.5	-1.1	0.9
Locomotion velocity, session 7	0.3	0.3	0.8	-0.9	0.2	-0.3	0.3	0.6	-0.7
Locomotion distance, session 7	0.2	0.3	0.5	-0.7	-0.4	0.3	-0.3	0.6	-0.5
Stereotopy head waving bouts, day 7	0.6	0.7	2.1	1.4	-0.4	0.7	-0.7	-0.5	0.9
Stereotopy head waving duration, day 7	0.3	0.4	0.9	0.9	0.5	-0.4	0.4	-0.7	0.6
Locomotion velocity, session 8	0.7	0.8	2.8	0.3	0.2	0.2	-0.2	-1.4	1.7
Locomotion distance, session 8	2.0	2.9	4.6	-1.0	2.2	-1.9	1.9	-1.8	1.1
Degree of sensitization distance	0.8	0.8	1.3	-1.1	1.0	-1.1	1.1	-0.3	-0.1
Degree of sensitization stereotypy	0.4	0.4	1.3	1.1	-0.4	0.5	-0.5	-0.2	0.6
Conditioned locomotion	0.4	0.5	0.9	-0.9	-0.5	0.4	-0.4	0.9	-0.8
Cocaine response after cond. corrected	0.1	0.2	0.4	-0.2	-0.3	0.1	-0.1	0.6	-0.6
Cocaine response after cond. not corrected	0.5	0.6	1.8	0.0	-0.3	-0.1	0.1	1.3	-1.3
Cocaine response before conditioning	0.3	0.4	0.9	0.4	0.1	-0.5	0.5	0.9	-0.9
Saline control response	0.3	0.4	1.9	1.4	-0.3	0.3	-0.3	0.1	0.3
Bone: connectivity density	0.5	0.7	3.0	-1.7	-0.5	0.2	-0.2	0.9	-0.5
Bone: cortical apparent density	0.7	0.9	1.5	-0.4	-1.2	1.0	-1.0	1.2	-0.9
Bone: cortical area	0.3	0.5	1.5	-1.2	0.7	-0.8	0.8	-0.2	0.1
Bone: cortical porosity	2.3	2.5	5.8	2.4	-1.6	1.7	-1.7	0.7	0.1
Bone: cortical porosity	3.3	3.6	7.8	2.8	-2.0	2.1	-2.1	0.9	0.2
Bone: cortical thickness	0.6	0.9	1.6	-1.3	1.1	-1.2	1.2	-0.3	-0.1
Bone: cortical thickness	0.2	0.2	0.4	0.0	0.5	-0.6	0.6	0.2	-0.5
Bone: cortical tissue density	0.7	0.9	1.4	-0.4	-1.2	0.9	-0.9	1.1	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.0	-0.3	0.4	-0.4	-0.1	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	-0.4	0.3	-0.3	0.4	-0.2
Condit. Reinf. active responses	0.4	0.4	0.9	0.5	-0.8	0.9	-0.9	0.0	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.6	-0.3	0.4	-0.4	-0.2	0.3
Incentive salience index mean	0.6	0.7	1.2	-0.5	-0.9	0.7	-0.7	1.1	-0.8
Condit. Reinf. lever presses	1.4	1.9	3.5	-0.5	-1.6	1.3	-1.3	1.9	-1.3
Condit. Reinf. active minus inactive responses	1.0	1.2	3.1	0.7	0.9	-0.4	0.4	-1.8	1.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.0	0.3	-0.1	0.1	-0.6	0.5
Condit. Reinf. active responses	0.9	1.2	2.9	1.0	0.9	-0.5	0.5	-1.7	1.5
Condit. Reinf. inactive responses	0.3	0.3	1.0	1.0	0.4	-0.3	0.3	-0.6	0.4
Condit. Reinf. lever presses	0.7	0.9	1.5	0.5	1.2	-1.2	1.2	-0.9	0.4
Condit. Reinf. lever reinforcers received	0.6	0.9	2.1	1.0	0.6	-0.2	0.2	-1.4	1.4
Conditioned reinforcement - actives	5.7	5.7	9.5	1.3	-3.1	3.0	-2.9	2.2	-0.9
Conditioned reinforcement - inactives	2.7	3.1	11.4	-3.4	-1.3	1.6	-1.6	0.2	0.6
Conditioned locomotion	3.6	4.4	7.8	0.1	-2.8	2.8	-2.7	1.7	-0.5
Patch foraging indifference point 0 sec	2.0	3.1	17.0	4.1	0.7	-0.8	0.9	-0.3	-0.1
Patch foraging indifference point AUC	0.6	0.7	1.2	-1.1	0.7	-0.4	0.4	-1.1	0.9
Delay disc. indifference point, 0s delay	0.8	0.8	1.9	1.4	-0.3	0.5	-0.5	-0.9	1.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.0	-0.4	0.5	-0.5	0.1	0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	0.6	-0.3	0.4	-0.4	0.0	0.2
Delay disc. indifference point, 24s delay	1.0	0.9	1.7	-0.8	-0.9	0.7	-0.7	1.3	-1.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.7	1.1	0.4	-0.2	0.2	-1.2	1.3
Delay disc. indifference point, 8s delay	0.8	0.8	1.4	-0.5	1.2	-1.2	1.2	-0.4	-0.2
Indifference point function ln k	0.5	0.7	1.7	0.6	-0.6	0.2	-0.2	1.3	-1.2
Indifference point function log k	0.5	0.7	1.7	0.6	-0.6	0.2	-0.2	1.3	-1.2
Patch foraging total patch changes 0 sec	1.7	2.7	14.7	3.8	0.5	-0.6	0.8	-0.1	-0.2
Patch foraging total patch changes 12 sec	1.8	2.4	12.3	3.5	0.6	-0.5	0.5	-0.8	0.6
Patch foraging total patch changes 18 sec	0.8	1.0	5.6	2.4	-0.0	0.2	-0.0	-0.4	0.4
Patch foraging total patch changes 24 sec	0.3	0.4	2.4	1.6	-0.0	-0.0	0.1	0.0	-0.1
Patch foraging total patch changes 6 sec	2.1	3.1	10.0	3.2	1.3	-1.1	1.2	-1.6	1.2
Patch foraging time to switch 0 sec	1.1	1.7	9.3	3.0	-0.5	0.4	-0.5	0.4	-0.2
Patch foraging water rate 0 sec	0.2	0.4	0.6	0.2	-0.7	0.6	-0.6	0.8	-0.6
Patch foraging water rate 12 sec	1.9	2.9	5.0	-1.8	1.9	-2.1	2.2	-0.2	-0.7
Patch foraging water rate 18 sec	1.1	1.4	3.8	-2.0	0.8	-1.1	1.1	0.6	-1.1
Patch foraging water rate 24 sec	3.1	4.3	12.5	-3.5	1.9	-2.1	2.2	-0.3	-0.6
Patch foraging water rate 6 sec	1.3	1.9	4.7	-2.2	-1.3	1.0	-0.9	1.5	-1.0
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	6.0	-2.4	-0.4	0.2	-0.2	1.1	-1.2
Distance traveled before self-admin	2.5	2.6	8.6	2.9	-1.4	1.2	-1.6	1.0	-0.4
Distance traveled after self-admin	2.2	2.5	13.0	3.6	-0.8	0.7	-0.5	0.7	-0.3
Extensor digitorum longus weight	0.9	3.6	4.8	-2.2	1.6	-2.2	2.2	0.8	-2.0
Bone: elastic displacement	0.1	0.1	0.3	0.0	0.2	-0.1	0.1	-0.6	0.6
Bone: elastic work	0.4	0.6	0.8	-0.7	0.9	-0.8	0.8	-0.7	0.4
Bone: endosteal estimation	0.1	0.1	0.3	-0.5	0.1	0.1	-0.1	-0.5	0.5
Bone: endosteal perimeter	0.1	0.1	0.4	-0.3	0.1	0.0	-0.0	-0.5	0.6
Epididymis fat weight	0.4	0.8	2.4	-1.6	0.7	-0.8	1.0	0.2	-0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.4	-0.3	0.3	-0.4	0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.3	0.6	-0.6	0.3	-0.6	0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.6	-0.3	-0.3	0.3	-0.5	-0.4	0.7
Delay discount exponential model param	0.0	0.0	0.1	-0.2	0.1	-0.0	0.0	-0.2	0.2
Extinction: sum of active levers before priming	0.2	0.2	0.7	-0.9	-0.4	0.4	-0.5	0.1	0.1
Active lever presses in extinction session 6	1.0	0.9	4.3	-2.1	-0.6	0.5	-0.6	0.6	-0.3
Bone: final force	0.1	0.2	0.9	-0.2	-0.1	0.2	-0.2	-0.6	0.9
Bone: final moment	0.2	0.3	0.8	-0.6	0.1	0.1	-0.1	-0.7	0.9
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.0	0.1	-0.0
Glucose	0.1	0.2	0.9	-0.9	0.3	-0.3	0.3	-0.1	-0.1
Heart weight	0.5	0.7	3.1	1.8	0.4	-0.2	0.4	-0.6	0.5
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.1	0.0	0.0
Intermittent access intake day 1-15 change	1.4	1.4	7.0	-2.6	0.7	-0.5	0.7	-0.2	-0.1
Intermittent access intake escalation	1.0	0.9	4.8	-2.2	0.5	-0.4	0.6	-0.1	-0.2
Intermittent access intake escalation 2	1.8	1.8	7.6	-2.8	1.0	-0.9	1.0	-0.5	0.1
Intermitt. access day 1 inactive lever presses	4.4	4.7	9.6	-3.1	-2.3	2.2	-2.4	1.6	-0.6
Intermitt. access day 15 inactive lever presses	2.3	2.5	11.5	-3.4	-0.6	0.8	-1.1	-0.6	1.0
Intermitt. access escalation Index	0.6	0.6	1.6	0.1	0.4	-0.7	0.6	0.8	-1.3
Intermittent access day 1 total infusions	13.5	15.6	65.2	8.1	-2.8	3.2	-3.0	0.8	0.7
Intermittent access day 15 total infusions	3.4	3.9	9.4	3.1	-1.9	2.3	-2.1	0.7	0.2
Intermittent access terminal intake (last 3 days)	3.2	3.5	5.7	2.3	-2.1	2.4	-2.2	0.8	0.2
Intermittent access total infusions	11.7	13.0	51.0	7.1	-2.8	3.1	-2.8	1.2	0.2
Intermittent access day 1 locomotion	5.8	6.1	12.0	3.5	-2.7	2.9	-2.8	0.8	0.6
Intermittent access day 15 total locomotion	3.3	3.5	6.4	0.1	-2.5	2.5	-2.4	1.6	-0.5
Intermittent access total locomotion	4.9	5.6	8.9	2.9	-2.8	3.0	-2.8	1.0	0.4
Intermittent access standard deviation	3.3	3.5	16.7	4.1	0.1	0.5	-0.1	-1.3	1.5
Left kidney weight	0.4	1.1	3.0	-0.0	0.4	-0.9	1.0	1.2	-1.7
Right kidney weight	0.5	1.4	2.9	1.5	0.4	-0.8	1.0	1.1	-1.7
Cocaine induced anxiety	0.7	0.8	2.9	-1.7	-0.8	0.8	-0.6	0.4	-0.1
Post-drug Anxiety	0.5	0.6	1.1	-1.1	-0.9	0.9	-0.5	0.6	-0.2
Baseline Anxiety	0.1	0.1	0.2	0.4	-0.2	0.1	-0.2	0.5	-0.5
Tail length	0.2	0.7	1.4	0.2	-1.0	0.7	-0.6	1.2	-0.8
Length with tail	0.3	1.2	3.9	2.0	-1.0	1.0	-0.7	0.9	-0.6
Length without tail	0.9	1.9	4.6	2.1	-1.4	1.6	-1.3	0.3	0.5
Times rat made contact with spout	0.3	0.3	1.3	1.1	0.1	-0.0	0.0	-0.4	0.6
Lifetime Intake	10.4	11.8	50.1	7.1	-2.5	2.7	-2.4	1.1	0.1
Liver weight, left	1.4	2.2	3.3	1.4	-1.8	1.8	-1.8	1.2	-0.6
Liver weight, right	1.1	1.9	2.7	1.1	-1.6	1.6	-1.5	1.3	-0.8
Locomotor activity	0.6	0.9	2.3	0.3	0.8	-0.5	0.6	-1.5	1.4
Locomotor testing distance	1.1	1.9	4.6	1.0	1.2	-0.7	0.8	-2.1	1.8
Locomotor testing rearing	3.0	4.6	11.7	0.9	1.8	-1.1	1.0	-3.4	3.1
Locomotion in novel chamber	2.8	3.5	6.1	1.1	-2.0	1.6	-1.6	2.5	-2.0
Locomotion in novel chamber post-restriction	1.2	1.5	4.9	0.6	0.4	0.1	-0.1	-1.9	2.2
Fecal boli incidents, locomotor time 1	2.9	3.2	5.1	-1.1	-2.0	1.8	-1.7	2.3	-1.7
Change in fecal boli incidents, locomotor task	3.5	3.3	5.9	-0.0	2.1	-1.7	1.8	-2.4	1.9
Time >=10cm from walls, locomotor time 1	1.1	1.1	3.9	-0.0	0.2	0.1	-0.1	-1.6	2.0
Bouts of movement, locomotor time 1	1.3	1.4	3.7	-0.6	0.9	-1.2	1.1	1.0	-1.9
Total resting periods, locomotor time 1	1.1	1.2	4.4	-0.5	0.3	-0.6	0.6	1.4	-2.1
Rest time, locomotor task time 1	0.8	0.9	2.5	0.3	0.5	-0.4	0.3	-1.4	1.6
Distance moved, locomotor task time 1	0.2	0.2	0.6	0.8	-0.5	0.6	-0.5	0.2	-0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.1	-0.4	0.4	-0.2	0.3	-0.3	0.2
Time >=10cm from walls, locomotor time 2	1.6	1.7	2.2	-1.5	1.5	-1.4	1.3	-1.2	0.6
Bouts of movement, locomotor time 2	0.3	0.3	0.6	0.1	-0.7	0.7	-0.8	-0.1	0.6
Total resting periods, locomotor time 2	0.3	0.3	0.6	0.2	-0.7	0.7	-0.7	-0.1	0.6
Rest time, locomotor task time 2	1.4	1.7	3.8	-0.1	1.2	-0.8	0.9	-1.9	1.8
Distance moved, locomotor task time 2	0.1	0.1	0.4	0.2	-0.1	-0.1	-0.0	0.5	-0.7
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.3	0.5	-0.6	0.4	-0.4	0.2
Light reinforcement 1	0.5	1.0	2.2	1.5	0.9	-0.8	0.9	-0.9	0.6
Light reinforcement 2	1.1	1.5	2.5	-0.2	1.1	-1.6	1.5	0.8	-1.5
Bone: marrow area	0.0	0.1	0.2	-0.5	0.0	0.1	-0.1	-0.4	0.5
Bone: maximum diameter	0.1	0.2	0.3	-0.5	0.4	-0.3	0.3	-0.6	0.6
Bone: maximum force	0.2	0.3	1.1	-0.4	0.3	-0.2	0.2	-0.8	1.0
Bone: maximum moment	0.3	0.5	0.9	-1.0	0.6	-0.4	0.4	-0.8	0.8
Mean time between licks in bursts	0.2	0.2	0.4	0.1	-0.6	0.4	-0.4	0.7	-0.5
Mean num. licks in bursts	0.1	0.2	0.4	-0.0	-0.3	0.2	-0.2	0.7	-0.7
Cd content in liver	1.3	1.5	3.5	-0.3	-1.2	0.8	-0.8	1.9	-1.6
Co content in liver	1.9	2.2	4.3	0.9	-1.9	2.1	-2.1	0.5	0.4
Cu content in liver	0.6	0.7	1.2	0.6	-0.6	0.9	-0.9	-0.6	1.1
Fe content in liver	1.0	1.2	2.1	0.1	-1.4	1.1	-1.1	1.4	-0.9
K content in liver	1.0	1.0	2.4	-1.1	-0.9	0.4	-0.4	1.6	-1.1
Mg content in liver	0.4	0.4	1.8	-1.3	0.0	-0.3	0.3	0.5	-0.5
Mn content in liver	1.4	1.6	3.0	-0.8	-1.5	1.1	-1.1	1.7	-1.1
Na content in liver	0.7	0.7	1.9	0.4	-0.5	0.9	-0.9	-0.7	1.4
Rb content in liver	1.4	1.7	3.4	0.6	-1.6	1.8	-1.8	0.2	0.8
Se content in liver	1.3	1.6	2.8	0.6	-1.7	1.6	-1.6	0.9	0.1
Sr content in liver	2.1	1.9	3.2	-0.9	1.8	-1.8	1.8	-1.1	0.3
Zn content in liver	1.1	1.2	2.2	-0.8	1.3	-1.5	1.5	-0.0	-0.6
Bone: minimum diameter	0.3	0.5	1.4	-1.2	0.6	-0.6	0.6	-0.5	0.3
Time in familiar zone, hab. session 1	1.3	1.3	1.8	-1.2	1.4	-1.3	1.3	-0.8	0.3
Time in novel zone, hab. session 1	0.6	0.6	1.9	1.4	-0.7	0.8	-0.8	-0.1	0.4
Total zone transitions, hab. session 1	1.8	2.5	5.5	-1.0	1.3	-0.8	0.8	-2.3	2.2
Total locomotion distance, hab. session 1	0.5	0.7	1.5	-0.1	0.8	-0.5	0.5	-1.2	1.1
Locomotion velocity, hab. session 1	0.5	0.7	1.6	-0.1	0.9	-0.6	0.6	-1.3	1.1
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.0	0.5	-0.4	0.4	-0.5	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.2	0.4	-0.6	0.6	0.1	-0.2
Total zone transitions, hab. session 2	1.9	2.5	3.9	-0.6	1.9	-1.6	1.6	-2.0	1.5
Total locomotion distance, hab. session 2	1.4	1.9	3.2	-0.2	1.8	-1.6	1.6	-1.4	0.9
Locomotion velocity, hab. session 2	1.3	1.7	2.7	-0.2	1.6	-1.4	1.4	-1.6	1.1
Novel to familiar place preference ratio	1.1	1.2	2.4	0.2	-1.4	1.5	-1.5	0.3	0.4
Novelty place preference	1.0	1.0	2.0	0.2	-1.2	1.4	-1.4	0.1	0.6
Time in novel zone, NPP test	0.7	0.7	1.5	0.1	-1.0	1.2	-1.2	-0.1	0.7
Total zone transitions, NPP test	1.4	2.0	3.4	-1.0	1.9	-1.7	1.7	-1.3	0.5
Total locomotion distance, NPP test	2.3	3.2	5.7	-0.9	2.4	-2.4	2.4	-1.1	-0.1
Locomotion velocity, NPP test	2.2	3.1	5.5	-1.0	2.3	-2.4	2.4	-1.0	-0.2
Intraocular pressure	0.0	0.0	0.1	0.4	0.1	-0.0	0.0	-0.2	0.1
Delta distance traveled before/after self-admin	0.4	0.4	0.9	0.5	0.7	-0.7	0.9	-0.5	0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.7	0.8	0.2	-0.1	0.5	-0.2	0.2
Parametrial fat weight	0.5	1.0	2.7	-1.0	-0.4	0.1	-0.1	1.4	-1.6
Pavlov. Cond. lever latency	2.1	2.7	5.2	1.6	1.6	-1.1	1.1	-2.3	1.9
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	-0.8	0.4	-0.5	0.5	-0.0	-0.2
Pavlov. Cond. change in total contacts	2.8	3.0	5.0	-0.4	-2.2	1.7	-1.7	2.2	-1.5
Pavlov. Cond. index score	1.1	1.4	2.6	-1.4	-0.9	0.5	-0.5	1.6	-1.5
Pavlov. Cond. latency score	1.3	1.6	3.1	-1.4	-1.1	0.7	-0.7	1.8	-1.6
Pavlov. Cond. lever contacts	2.0	2.4	4.9	-1.8	-1.0	0.4	-0.4	2.2	-2.2
Pavlov. Cond. magazine entry number	0.5	0.7	1.5	1.2	0.3	0.0	-0.0	-1.1	1.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	0.9	-0.6	0.9	-0.9	-0.5	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	2.6	-1.3	-1.0	0.6	-0.6	1.6	-1.4
Pavlov. Cond. response bias	0.8	1.0	2.1	-1.2	-0.5	0.1	-0.1	1.4	-1.5
Pavlov. Cond. lever latency	2.5	3.4	6.0	-0.2	-2.5	2.3	-2.3	1.8	-0.9
Pavlov. Cond. magazine entry latency	1.3	1.5	3.1	-0.0	1.5	-1.8	1.8	0.1	-0.8
Pavlov. Cond. change in total contacts	3.3	4.5	8.1	0.6	2.5	-2.0	2.0	-2.8	2.1
Pavlov. Cond. index score	2.3	3.0	5.4	0.1	2.3	-2.3	2.3	-1.2	0.3
Pavlov. Cond. latency score	2.7	3.3	6.3	0.1	2.5	-2.5	2.5	-1.2	0.1
Pavlov. Cond. lever contacts	2.2	3.0	5.3	0.2	2.3	-2.2	2.2	-1.5	0.6
Pavlov. Cond. magazine entry number	1.9	2.3	4.1	-0.3	-2.0	2.0	-2.0	1.3	-0.6
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	0.3	-1.2	1.0	-1.0	1.2	-0.9
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.1	5.9	0.1	2.4	-2.4	2.4	-1.1	0.2
Pavlov. Cond. response bias	2.0	2.7	4.7	0.2	2.2	-2.1	2.1	-1.4	0.6
Time in closed arm before self-admin	2.7	3.1	13.0	3.6	1.3	-1.1	1.1	-1.0	0.5
Time in closed arm after self-admin	1.4	1.4	8.6	2.9	0.2	-0.2	0.2	-0.0	0.0
Time in open arm before self-admin	1.1	1.2	1.9	-1.1	-1.4	1.4	-1.3	0.6	0.0
Time in open arm after self-admin	0.5	0.6	2.4	-1.6	0.5	-0.4	0.5	-0.5	0.2
Bone: periosteal estimation	0.1	0.3	1.1	-1.1	0.3	-0.4	0.4	-0.2	0.1
Bone: periosteal perimeter	0.3	0.6	0.9	-0.4	0.9	-0.8	0.8	-0.8	0.4
Bone: post-yield work	0.2	0.3	0.9	-0.0	0.2	0.0	-0.0	-0.8	0.9
Progressive ratio test 1 active lever presses	6.2	6.5	26.9	5.2	-1.9	2.1	-1.7	0.7	0.3
Progressive ratio test 1 breakpoint	5.7	6.0	25.1	5.0	-1.8	2.0	-1.6	0.7	0.3
Progressive ratio test 1 inactive lever presses	1.1	1.2	7.0	2.7	-0.1	0.3	0.0	-0.1	0.3
Progressive ratio test 2 active lever presses	11.6	12.5	48.0	6.9	-2.9	2.9	-2.6	1.7	-0.4
Progressive ratio test 2 breakpoint	10.9	12.3	49.6	7.0	-2.8	2.8	-2.5	1.6	-0.4
Progressive ratio test 2 inactive lever presses	3.4	3.9	7.8	2.8	-2.1	2.4	-2.2	0.7	0.4
Incentive Sensitization - Responses	8.5	8.6	36.5	6.0	-2.1	2.0	-2.0	1.6	-0.7
Incentive Sensitization - Breakpoint	8.5	8.7	35.2	5.9	-2.2	2.1	-2.0	1.7	-0.8
Sum of active levers in priming session hrs 5-6	0.8	0.7	3.8	-1.9	0.2	-0.3	0.6	-0.3	0.2
Progressive ratio	0.6	0.7	1.2	-1.1	-1.0	0.9	-0.9	0.6	-0.2
Food seeking constrained by brief footshock	1.0	1.2	2.2	-1.1	0.8	-1.1	1.1	0.8	-1.5
Seeking ratio, punishment vs. effort	1.4	1.7	3.1	0.7	1.5	-1.8	1.8	0.0	-1.0
Retroperitoneal fat weight	0.1	0.4	0.7	-0.4	0.8	-0.7	0.9	-0.5	-0.1
Reaction time number correct	3.2	4.6	8.1	0.9	2.8	-2.6	2.6	-2.1	0.9
Reaction time mean minus median	1.8	2.4	4.2	1.0	2.0	-2.0	2.0	-1.2	0.3
Reaction time mean minus median AUC	2.0	2.6	5.0	0.6	2.2	-2.2	2.2	-0.9	-0.2
Reaction time num false alarms	1.6	2.1	3.4	-0.4	-1.8	1.5	-1.5	1.8	-1.3
Reaction time num false alarms AUC	2.0	2.8	4.7	-0.7	-2.0	1.6	-1.5	2.2	-1.6
Reaction time trials correct on left	3.2	4.6	8.1	0.9	2.8	-2.6	2.6	-2.1	0.9
Reaction time trials on left	3.5	5.1	8.8	0.9	3.0	-2.8	2.8	-2.2	0.9
Reaction time mean	0.8	1.1	5.9	2.4	0.0	0.1	-0.1	-0.6	0.6
Reaction time mean AUC	0.8	1.1	5.3	2.3	-0.3	0.5	-0.6	-0.5	0.7
Median of all reaction times	1.0	1.3	6.0	2.5	-0.6	0.8	-0.8	-0.2	0.5
Reaction time omissions	1.6	2.1	3.5	0.9	1.9	-1.7	1.7	-1.5	0.6
Reaction time false alarm rate	4.5	6.3	9.5	-1.4	-3.1	2.5	-2.5	3.1	-2.0
Reaction time premature initiation rate	1.4	1.9	2.7	-1.3	1.1	-1.5	1.6	0.9	-1.6
Reaction time premature initiations	2.9	4.2	8.6	-0.6	2.6	-2.8	2.9	-0.4	-1.0
Std. dev. reaction times	1.2	1.6	4.8	2.2	1.2	-1.1	1.1	-0.9	0.4
Reaction time trials completed	3.5	5.1	8.8	0.9	3.0	-2.8	2.8	-2.2	0.9
Reaction time trials AUC	3.3	4.7	8.1	1.1	2.8	-2.6	2.7	-2.1	0.8
Run reversals in cocaine runway, females	0.7	0.7	2.8	0.1	0.2	-0.4	0.4	1.1	-1.7
Run reversals in cocaine runway, males	1.1	1.1	1.6	0.9	-1.3	1.1	-1.1	1.1	-0.6
Latency to leave start box in cocaine runway	0.2	0.3	0.4	-0.6	0.4	-0.5	0.5	0.3	-0.6
Latency to leave start box in cocaine runway, F	0.4	0.4	1.5	-1.2	-0.3	0.1	-0.1	0.6	-0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.1	0.3	-0.5	0.5	0.3	-0.6
Std. dev. time between licks in bursts	0.3	0.3	1.0	-0.5	-0.3	0.1	-0.1	0.9	-1.0
Total sessions with >9 infusions	7.1	7.8	25.6	5.1	-2.6	2.7	-2.4	1.3	-0.1
Short access day 1 total inactive lever presses	0.5	0.5	1.1	-0.2	-1.0	0.9	-1.0	0.5	-0.0
Short access day 10 total inactive lever presses	2.6	2.9	14.6	-3.8	0.8	-1.0	0.9	-0.2	-0.2
Short access day 1 total infusions	3.0	3.2	13.0	3.6	-1.5	1.3	-0.9	1.2	-0.6
Short access day 10 total infusions	20.4	22.7	115.0	10.7	-2.4	2.8	-2.5	0.9	0.3
Short access total infusions	10.7	12.0	62.0	7.9	-1.8	2.0	-1.5	0.9	-0.0
Short access day 1 locomotion	2.4	2.6	11.2	3.3	-1.1	1.1	-1.1	0.7	-0.2
Short access day 10 total locomotion	1.3	1.4	5.2	2.3	-0.9	1.1	-1.0	-0.1	0.7
Short access total locomotion	6.2	6.4	28.7	5.4	-1.7	1.9	-1.7	0.5	0.4
One hour access (0.3 mA shock)	0.3	0.4	1.1	0.2	-0.7	1.0	-0.8	0.2	0.2
Compulsive drug intake	5.0	5.1	22.5	-4.7	1.1	-1.6	1.4	0.5	-1.3
One hour access (shock baseline)	2.7	3.1	5.3	2.3	-1.8	2.3	-2.1	0.4	0.5
Social response proportion	0.8	0.8	1.4	-1.1	1.0	-1.0	1.2	-0.6	0.2
Social responses	3.9	5.0	9.0	-1.4	2.4	-1.9	2.0	-3.0	2.5
Social time	2.5	3.3	8.2	-0.1	1.7	-1.1	1.1	-2.9	2.5
Soleus weight	0.3	0.8	1.5	-1.0	0.2	-0.7	0.7	1.1	-1.2
Bone: stiffness	0.4	0.6	1.0	0.1	-0.8	1.0	-1.0	-0.2	1.0
Tibialis anterior weight	0.8	2.8	5.1	-2.3	1.5	-1.9	1.9	0.5	-1.3
Time to tail flick, vehicle, before self-admin	0.7	0.7	2.6	-1.6	-0.4	0.6	-0.7	-0.3	0.6
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	0.6	0.4	-0.2	0.4	-0.9	0.8
Time to tail flick, test, before self-admin	1.3	1.3	2.2	0.9	-1.5	1.4	-1.3	1.0	-0.4
Time to tail flick, test, after self-admin	1.4	1.5	4.7	2.2	-0.8	0.9	-1.5	0.1	0.4
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	5.8	2.4	0.5	-0.5	1.1	-0.3	0.0
Delta time to tail flick, test, before/after SA	1.3	1.2	3.0	1.7	1.2	-1.0	0.5	-1.0	0.5
Tibia length	0.5	1.5	2.4	-1.1	-1.4	1.1	-1.1	1.5	-1.1
Ambulatory time before self-admin	3.3	3.5	9.5	3.1	-1.9	1.6	-1.5	1.5	-0.8
Ambulatory time after self-admin	4.5	5.0	21.1	4.6	-1.7	1.6	-1.5	1.0	-0.3
Bone: tissue strength	1.3	1.3	2.2	-0.3	1.5	-1.4	1.4	-1.1	0.5
Total heroin consumption	1.9	2.2	8.0	-2.8	-1.0	1.1	-1.5	-0.1	0.6
Bone: trabecular number	0.3	0.4	1.0	-1.0	-0.6	0.6	-0.6	0.0	0.6
Bone: trabecular spacing	0.4	0.6	1.2	1.1	0.8	-0.8	0.8	-0.0	-0.5
Bone: trabecular thickness	0.2	0.3	1.0	0.0	0.2	-0.0	0.0	-0.7	1.0
Bone: trabecular tissue density	0.7	1.0	1.9	1.4	-0.9	1.2	-1.2	-0.3	0.7
Water consumed over 24 hours	0.3	0.4	1.0	0.9	-0.1	0.2	-0.2	-0.6	1.0
Number of responses in last shaping day	4.9	5.1	15.6	3.9	-2.2	2.3	-1.9	1.2	-0.2