Hub : Genes

Tanc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Tanc2	0.18	0.07	1.7e-16	0.1	0.11	0.11	0.11	2.4e-15	1.3e-16	2.1e-16	8.4e-17
2	BLA	gene expression	Tanc2	0.18	0.09	6.9e-08	0.13	0.11	0.13	0.14	2.0e-07	1.4e-06	2.3e-07	1.3e-07
3	Adipose	gene expression	Tanc2	0.23	0.09	0.0e+00	0.22	0.2	0.21	0.21	1.1e-23	1.4e-21	2.2e-23	4.6e-23
4	Brain	gene expression	Tanc2	0.05	0.03	1.0e-03	0.02	0.02	0.02	0.02	6.9e-03	1.1e-02	7.5e-03	8.8e-03
5	RMTg	isoform ratio	XM_039086150.2	0.15	0.09	5.3e-03	0.11	0.12	0.11	0.1	8.8e-04	5.3e-04	9.0e-04	1.3e-03
6	PL	gene expression	Tanc2	0.04	0.03	3.2e-03	0.01	0	0	0	4.1e-02	1.8e-01	1.5e-01	2.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	2.0	3.7	11.0	-1.8	-1.2	-2.2	0.4	1.1	3.3
Area under the delay curve	0.2	0.3	0.6	-0.3	-0.7	-0.8	0.5	0.1	0.5
BMI with tail	1.4	4.9	15.3	-1.3	-1.9	-1.7	1.6	-3.9	-1.7
BMI without tail	1.4	7.6	15.9	-2.3	-3.1	-2.8	2.6	-4.0	-0.6
Body weight	3.3	14.4	26.8	-3.8	-4.0	-3.9	3.6	-5.2	0.1
Weight adjusted by age	0.2	0.7	1.9	0.9	0.6	1.0	-0.3	0.1	-1.4
Bone surface	4.2	8.2	13.5	-3.6	-2.7	-3.7	1.7	-1.0	3.3
Bone volume	3.7	7.3	11.7	-3.3	-2.6	-3.4	1.6	-0.6	3.4
Breakpoint value in progressive ratio session	0.0	0.1	0.2	-0.4	-0.3	0.0	0.0	-0.0	0.4
Number of licking bursts	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.1	-0.3	-0.2
Context. condit. distance diff. score	0.7	0.8	2.9	0.8	0.4	0.8	-0.5	-0.5	-1.7
Locomotion velocity, session 1	1.2	1.3	2.5	-1.4	-1.2	-0.9	1.1	0.1	1.6
Locomotion distance, session 1	0.2	0.3	0.7	-0.2	-0.3	-0.0	0.5	0.7	0.8
Locomotion velocity, session 2	0.5	0.6	1.4	-1.0	-0.4	-0.1	0.9	0.6	1.2
Locomotion distance, session 2	0.2	0.3	0.9	0.3	0.2	0.9	0.2	0.9	0.3
Locomotion velocity, session 3	0.2	0.2	0.6	0.1	0.5	0.8	-0.4	0.5	0.0
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.3	0.1	-0.3	0.1	0.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.6	0.3	0.4	0.3	-0.8	1.2	1.0
Stereotopy head waving duration, day 3	0.3	0.3	0.7	0.6	0.4	0.8	-0.5	0.8	0.2
Locomotion velocity, session 7	0.5	0.5	1.0	0.4	0.9	0.7	-0.8	1.0	0.2
Locomotion distance, session 7	0.3	0.4	0.7	0.4	0.8	0.8	-0.6	0.4	-0.3
Stereotopy head waving bouts, day 7	0.6	0.7	1.9	0.4	0.8	0.6	-0.9	1.4	0.6
Stereotopy head waving duration, day 7	1.4	1.7	4.6	1.0	1.3	1.4	-1.0	2.1	0.6
Locomotion velocity, session 8	1.0	1.2	2.5	-0.5	-0.9	0.2	1.5	-1.6	-1.0
Locomotion distance, session 8	0.2	0.2	0.7	0.4	-0.0	0.8	0.4	0.2	-0.5
Degree of sensitization distance	0.1	0.1	0.3	0.4	-0.1	0.5	0.2	-0.3	-0.6
Degree of sensitization stereotypy	0.8	0.9	1.8	0.8	1.1	1.0	-1.0	1.3	0.0
Conditioned locomotion	0.2	0.2	0.5	-0.4	-0.4	-0.3	0.7	-0.2	0.7
Cocaine response after cond. corrected	0.4	0.5	1.3	0.4	0.6	0.1	-1.2	-0.6	-0.9
Cocaine response after cond. not corrected	0.3	0.5	2.0	0.2	0.7	0.1	-1.4	-0.1	-0.4
Cocaine response before conditioning	0.3	0.4	1.2	-0.4	-0.1	-0.1	-0.1	1.1	1.1
Saline control response	1.4	1.9	4.1	-1.2	-1.7	-1.1	2.0	-1.4	0.1
Bone: connectivity density	2.5	3.9	10.7	-2.0	-1.4	-2.4	0.5	0.9	3.3
Bone: cortical apparent density	3.3	5.2	9.2	2.4	2.4	2.2	-2.3	3.0	0.3
Bone: cortical area	1.4	2.2	5.2	-1.8	-1.1	-2.3	0.6	-0.9	1.6
Bone: cortical porosity	6.9	7.5	13.5	-3.7	-2.5	-3.4	1.9	-2.9	1.3
Bone: cortical porosity	5.7	6.3	10.5	-3.2	-2.1	-3.2	1.6	-3.0	1.0
Bone: cortical thickness	2.7	4.5	8.2	1.9	2.7	1.2	-2.9	2.4	0.4
Bone: cortical thickness	2.4	3.0	5.4	1.4	2.1	0.7	-2.3	2.3	0.6
Bone: cortical tissue density	3.2	5.0	9.2	2.4	2.4	2.2	-2.2	3.0	0.4
Condit. Reinf. active minus inactive responses	2.3	2.6	4.0	-2.0	-1.7	-1.8	1.7	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.4	-1.1	-0.7	-1.2	0.5	-0.5	0.6
Condit. Reinf. active responses	3.0	3.8	5.5	-2.3	-2.1	-1.9	2.3	-1.1	1.7
Condit. Reinf. inactive responses	1.3	1.7	3.1	-1.4	-1.5	-0.9	1.8	-0.4	1.5
Incentive salience index mean	2.3	2.9	4.7	-2.2	-1.5	-1.9	1.6	-0.5	2.0
Condit. Reinf. lever presses	0.9	1.3	4.5	-1.3	-0.4	-0.6	0.8	0.5	2.1
Condit. Reinf. active minus inactive responses	4.8	7.4	11.1	-3.3	-2.9	-3.2	2.4	-0.9	2.8
Condit. Reinf. active-inactive response ratio	3.1	4.9	7.3	-2.7	-2.3	-2.7	1.9	-0.5	2.4
Condit. Reinf. active responses	5.9	8.5	12.1	-3.5	-3.2	-3.3	2.9	-1.3	2.7
Condit. Reinf. inactive responses	1.4	2.0	3.6	-1.5	-1.6	-1.3	1.9	-0.5	1.3
Condit. Reinf. lever presses	1.8	2.6	4.0	-2.0	-1.8	-1.7	1.7	-0.6	1.6
Condit. Reinf. lever reinforcers received	5.5	7.7	11.2	-3.3	-3.1	-3.2	2.7	-1.1	2.7
Conditioned reinforcement - actives	0.2	1.0	1.8	-0.8	-1.0	-0.7	1.2	-1.4	-0.6
Conditioned reinforcement - inactives	0.5	1.3	2.4	-1.2	-1.4	-1.2	0.8	-1.6	-0.2
Conditioned locomotion	2.5	3.7	5.2	-2.1	-2.3	-2.2	1.9	-1.9	0.3
Patch foraging indifference point 0 sec	1.9	5.4	8.2	-2.5	-2.9	-2.6	2.5	-1.1	1.9
Patch foraging indifference point AUC	0.3	0.8	1.4	-0.7	-1.1	-0.8	1.2	-0.9	-0.1
Delay disc. indifference point, 0s delay	0.3	0.4	1.3	0.5	0.6	0.2	-0.4	1.1	0.2
Delay disc. indifference point, 16s delay	0.7	1.1	1.8	-0.9	-1.3	-1.3	0.9	-1.1	0.3
Delay disc. indifference point, 2s delay	1.0	1.1	3.0	-0.7	-0.8	-1.0	0.8	1.0	1.7
Delay disc. indifference point, 24s delay	1.2	2.0	2.8	-1.3	-1.7	-1.5	1.6	-1.6	0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.5	0.4	0.1	-0.6	0.7	-0.3
Delay disc. indifference point, 8s delay	0.2	0.3	0.9	0.0	-0.2	-0.3	-0.2	0.9	0.8
Indifference point function ln k	0.2	0.5	1.8	-0.0	0.4	0.3	-0.4	1.0	1.3
Indifference point function log k	0.2	0.5	1.8	-0.0	0.4	0.3	-0.4	1.0	1.3
Patch foraging total patch changes 0 sec	2.0	5.8	8.8	-2.7	-3.0	-2.7	2.6	-1.3	1.9
Patch foraging total patch changes 12 sec	3.0	4.0	6.9	-2.1	-2.4	-2.0	2.6	-1.0	1.3
Patch foraging total patch changes 18 sec	1.2	2.8	4.1	-1.8	-2.0	-1.9	1.8	-1.7	0.3
Patch foraging total patch changes 24 sec	1.2	4.1	6.1	-2.2	-2.5	-2.4	2.1	-0.8	1.7
Patch foraging total patch changes 6 sec	1.9	3.2	4.3	-2.0	-2.1	-2.0	2.1	-1.1	1.2
Patch foraging time to switch 0 sec	0.1	0.4	0.7	0.4	0.8	0.8	-0.4	0.4	-0.5
Patch foraging water rate 0 sec	0.7	2.7	4.1	-1.7	-2.0	-2.0	1.4	-1.3	1.2
Patch foraging water rate 12 sec	0.1	0.6	1.5	0.7	0.8	0.5	-1.2	0.1	-0.7
Patch foraging water rate 18 sec	0.2	0.6	1.8	-0.2	-0.1	-0.6	-0.4	1.0	1.3
Patch foraging water rate 24 sec	0.0	0.1	0.3	0.1	0.2	0.1	-0.5	-0.1	-0.1
Patch foraging water rate 6 sec	0.4	0.6	1.7	-0.5	-0.4	-0.9	-0.4	0.5	1.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.9	0.4	0.1	0.2	0.1	-0.8	-1.0
Distance traveled before self-admin	0.1	0.3	0.8	0.2	0.4	0.1	-0.9	-0.3	-0.8
Distance traveled after self-admin	0.2	0.4	1.1	0.2	0.6	0.2	-0.8	-0.6	-1.0
Extensor digitorum longus weight	1.8	7.1	20.5	3.0	1.9	2.5	-1.0	-1.5	-4.5
Bone: elastic displacement	1.1	1.4	2.8	1.1	1.5	0.9	-1.7	1.0	-0.4
Bone: elastic work	0.2	0.3	0.8	-0.5	0.2	-0.9	-0.2	0.1	0.7
Bone: endosteal estimation	10.1	24.7	37.2	-6.1	-5.7	-5.4	4.8	-4.5	2.4
Bone: endosteal perimeter	12.0	29.3	38.2	-6.2	-5.9	-6.2	5.4	-5.7	1.7
Epididymis fat weight	0.2	1.2	1.9	-1.0	-1.3	-0.8	1.3	-1.4	-0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	0.3	0.4	0.4	-0.8	0.6	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.2	-0.2	0.6	0.6	0.1	-0.1
Diff in mean of infusions in LGA sessions	1.0	1.7	3.0	1.7	1.4	1.7	-0.7	1.3	-0.6
Delay discount exponential model param	0.3	0.4	0.8	0.4	0.8	0.9	-0.6	0.1	-0.5
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	-0.0	0.5	0.4	-0.1	0.4
Active lever presses in extinction session 6	1.4	1.4	2.1	-1.4	-1.4	-1.3	1.0	-1.3	0.4
Bone: final force	0.6	1.0	2.1	-1.3	-0.7	-1.5	0.1	-0.3	1.2
Bone: final moment	0.7	1.1	2.3	-1.4	-0.7	-1.5	0.0	-0.3	1.4
Food consumed during 24 hour testing period	1.8	3.6	7.2	-1.7	-2.3	-1.1	2.7	-2.3	0.2
Glucose	1.4	2.2	4.4	1.3	1.6	1.5	-1.4	-0.4	-2.1
Heart weight	0.4	0.6	1.9	0.5	0.6	0.2	-0.7	-0.9	-1.4
Delay discount hyperbolic model param	0.3	0.4	0.8	0.5	0.8	0.9	-0.6	-0.1	-0.6
Intermittent access intake day 1-15 change	0.1	0.6	2.0	0.0	0.1	0.3	0.4	-1.1	-1.4
Intermittent access intake escalation	0.2	0.9	2.8	-0.5	-0.4	-0.2	0.9	-1.7	-1.3
Intermittent access intake escalation 2	0.5	0.8	2.5	-0.6	-0.4	-0.3	0.8	-1.6	-1.0
Intermitt. access day 1 inactive lever presses	0.3	4.0	5.8	-2.4	-2.4	-2.2	2.1	-0.9	1.6
Intermitt. access day 15 inactive lever presses	0.6	3.0	4.7	-1.9	-2.2	-2.2	1.6	-0.6	1.5
Intermitt. access escalation Index	1.1	3.4	6.2	1.9	1.9	1.8	-2.5	0.5	-1.8
Intermittent access day 1 total infusions	0.3	0.8	1.5	-1.2	-1.2	-0.8	0.8	-0.9	0.4
Intermittent access day 15 total infusions	1.1	2.7	6.5	-1.4	-1.6	-1.0	1.7	-2.5	-1.1
Intermittent access terminal intake (last 3 days)	2.0	3.5	6.5	-1.9	-2.1	-1.5	2.0	-2.5	-0.4
Intermittent access total infusions	2.2	2.6	3.9	-1.7	-2.0	-1.4	1.7	-2.0	-0.1
Intermittent access day 1 locomotion	2.2	4.0	5.5	-2.3	-2.3	-2.2	1.8	-2.1	0.5
Intermittent access day 15 total locomotion	1.4	5.4	8.0	-2.4	-2.8	-2.2	2.5	-2.8	0.1
Intermittent access total locomotion	5.9	7.0	10.1	-3.0	-3.2	-2.8	2.9	-2.5	0.9
Intermittent access standard deviation	0.1	0.6	1.0	-1.0	-0.9	-0.5	1.0	-0.7	0.3
Left kidney weight	0.0	0.3	0.8	0.2	0.6	-0.1	-0.9	0.6	0.0
Right kidney weight	0.0	0.1	0.3	-0.3	0.1	-0.5	-0.5	-0.0	0.1
Cocaine induced anxiety	0.2	0.6	2.0	0.5	0.9	0.1	-1.4	0.5	0.1
Post-drug Anxiety	0.5	0.5	1.3	0.7	0.9	0.2	-1.2	0.4	-0.5
Baseline Anxiety	0.1	0.2	0.5	0.4	0.1	0.3	0.4	-0.1	-0.7
Tail length	1.7	9.0	12.4	-3.5	-3.3	-3.4	2.8	-1.6	2.9
Length with tail	1.6	7.2	9.9	-3.1	-2.9	-2.9	2.8	-2.4	1.7
Length without tail	0.1	0.5	1.2	-0.7	-0.5	-0.4	0.9	-1.1	0.0
Times rat made contact with spout	0.4	0.5	0.9	-0.8	-0.8	-0.7	0.6	-0.9	0.3
Lifetime Intake	2.6	3.2	5.0	-2.0	-2.2	-1.7	1.8	-2.0	0.3
Liver weight, left	2.7	4.7	7.9	-2.8	-2.2	-2.1	2.1	-1.5	2.1
Liver weight, right	0.7	1.3	2.7	0.5	1.0	-0.1	-1.6	1.6	1.0
Locomotor activity	0.3	0.4	1.0	-0.7	-1.0	-0.6	0.7	-0.5	-0.2
Locomotor testing distance	0.5	1.3	2.0	-1.2	-1.4	-0.9	1.3	-1.2	-0.4
Locomotor testing rearing	0.3	0.9	1.6	-1.0	-1.0	-0.6	1.0	-1.3	-0.8
Locomotion in novel chamber	0.3	0.4	1.3	0.3	0.8	0.3	-0.7	-0.4	-1.1
Locomotion in novel chamber post-restriction	0.5	1.5	2.8	-1.2	-1.3	-1.7	1.0	-1.2	0.7
Fecal boli incidents, locomotor time 1	0.1	0.3	1.4	-0.1	-0.3	0.2	0.2	-1.2	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.4	0.2	-0.3	0.1	-0.1
Time >=10cm from walls, locomotor time 1	2.7	3.4	4.8	1.8	2.2	2.0	-2.0	0.4	-2.0
Bouts of movement, locomotor time 1	0.2	0.3	0.4	0.6	0.6	0.6	-0.4	0.6	0.1
Total resting periods, locomotor time 1	0.2	0.3	0.5	0.6	0.6	0.6	-0.4	0.7	0.1
Rest time, locomotor task time 1	0.2	0.3	0.8	0.1	0.2	0.1	-0.4	0.9	0.9
Distance moved, locomotor task time 1	0.1	0.3	0.6	-0.5	-0.5	-0.4	0.5	-0.8	-0.2
Vertical activity count, locomotor time 1	0.0	0.2	0.5	-0.6	-0.3	-0.5	0.4	-0.7	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.0	0.5	0.1	-0.7	-0.0	-0.5
Bouts of movement, locomotor time 2	0.0	0.1	0.3	0.5	0.4	0.3	-0.2	0.1	-0.6
Total resting periods, locomotor time 2	0.1	0.4	0.6	0.7	0.8	0.6	-0.6	0.3	-0.7
Rest time, locomotor task time 2	1.8	3.1	4.6	2.1	1.9	2.1	-1.7	1.2	-1.3
Distance moved, locomotor task time 2	0.3	0.4	0.8	-0.9	-0.5	-0.8	0.3	-0.2	0.9
Vertical activity count, locomotor time 2	1.2	2.7	4.3	-2.1	-1.5	-1.9	1.4	-0.7	1.9
Light reinforcement 1	0.4	1.7	3.6	-0.8	-1.2	-0.9	1.7	0.8	1.9
Light reinforcement 2	0.9	2.0	4.9	-1.1	-1.3	-1.4	1.3	1.0	2.2
Bone: marrow area	9.7	23.8	35.9	-6.0	-5.6	-5.3	4.6	-4.5	2.4
Bone: maximum diameter	4.3	8.7	14.9	-3.6	-3.1	-3.9	2.4	-2.5	1.8
Bone: maximum force	1.0	2.0	4.0	-1.8	-1.2	-2.0	0.7	-1.2	1.2
Bone: maximum moment	1.2	2.2	4.3	-1.9	-1.2	-2.1	0.7	-1.1	1.4
Mean time between licks in bursts	0.2	0.9	2.8	-0.1	-0.4	0.1	0.3	-1.7	-1.5
Mean num. licks in bursts	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.3	-0.4	0.2
Cd content in liver	3.8	4.2	6.9	2.6	2.3	2.3	-1.6	1.1	-2.0
Co content in liver	1.3	1.5	2.9	1.5	1.1	1.4	-0.6	0.4	-1.7
Cu content in liver	0.7	0.8	1.3	-1.0	-0.9	-1.1	1.1	-0.1	0.9
Fe content in liver	0.2	0.2	0.7	0.0	0.6	0.1	0.1	0.9	0.4
K content in liver	0.6	0.6	1.2	-0.7	-0.6	-0.4	0.9	0.6	1.1
Mg content in liver	1.0	1.1	4.4	0.5	0.5	0.6	-0.1	2.1	1.2
Mn content in liver	1.8	2.0	6.7	-0.2	0.2	0.1	-0.2	2.6	2.3
Na content in liver	0.5	0.6	1.5	-0.8	-0.6	-0.6	0.8	0.3	1.2
Rb content in liver	3.2	3.7	6.8	2.0	2.2	2.1	-1.6	2.6	-0.1
Se content in liver	0.9	1.1	1.6	1.3	1.2	1.0	-1.0	0.9	-0.6
Sr content in liver	1.1	0.9	1.8	-1.1	-1.0	-1.3	0.5	-1.1	0.1
Zn content in liver	0.3	0.4	0.6	0.7	0.8	0.3	-0.8	0.5	-0.5
Bone: minimum diameter	10.8	20.8	28.9	-5.4	-4.9	-5.3	4.3	-4.6	2.2
Time in familiar zone, hab. session 1	0.6	0.6	1.7	-0.2	-0.7	-0.2	1.0	-1.3	-0.7
Time in novel zone, hab. session 1	0.7	0.7	1.5	0.6	1.0	0.5	-1.2	1.2	0.2
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.2	-0.2	0.2	0.6	-0.6	-0.3
Total locomotion distance, hab. session 1	0.7	0.9	2.3	-1.1	-0.8	-1.0	0.7	0.2	1.5
Locomotion velocity, hab. session 1	0.9	1.2	2.2	-1.3	-1.1	-1.1	1.0	-0.0	1.5
Time in familiar zone, hab. session 2	0.8	1.0	2.2	-0.4	-0.8	0.0	1.2	-1.5	-1.1
Time in novel zone, hab. session 2	1.2	1.3	2.8	0.4	0.7	-0.3	-1.5	1.7	1.4
Total zone transitions, hab. session 2	0.2	0.2	0.7	0.1	-0.2	0.8	0.8	-0.0	-0.2
Total locomotion distance, hab. session 2	0.5	0.6	1.5	-0.3	-0.7	-0.2	1.0	0.7	1.2
Locomotion velocity, hab. session 2	0.4	0.5	1.3	-0.2	-0.6	-0.0	0.9	0.7	1.1
Novel to familiar place preference ratio	0.3	0.4	0.7	-0.8	-0.5	-0.7	0.3	-0.8	0.3
Novelty place preference	0.1	0.2	0.3	-0.6	-0.3	-0.5	0.1	-0.5	0.2
Time in novel zone, NPP test	0.1	0.1	0.2	-0.5	-0.2	-0.4	-0.1	-0.4	0.1
Total zone transitions, NPP test	0.2	0.3	0.7	-0.0	-0.3	0.4	0.7	0.8	0.8
Total locomotion distance, NPP test	0.8	1.1	3.2	-0.7	-0.9	-0.8	0.7	0.9	1.8
Locomotion velocity, NPP test	0.5	0.7	1.8	-0.5	-1.0	-0.5	0.9	0.5	1.3
Intraocular pressure	1.1	1.8	5.2	-0.8	-1.4	-1.0	1.1	-2.3	-0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.6	0.6	0.5	-0.3	0.3	-0.4
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	0.3	0.1	-0.0	0.2	-0.0
Parametrial fat weight	0.4	1.0	2.8	-1.1	-0.7	-1.0	0.5	0.3	1.7
Pavlov. Cond. lever latency	1.7	2.1	4.1	2.0	1.2	1.4	-1.1	0.5	-1.9
Pavlov. Cond. magazine entry latency	4.1	5.2	8.9	-2.8	-2.3	-2.3	1.9	-0.6	3.0
Pavlov. Cond. change in total contacts	3.6	3.9	7.0	-2.5	-1.7	-1.9	1.8	-0.4	2.6
Pavlov. Cond. index score	3.3	4.2	7.0	-2.6	-1.9	-2.0	1.8	-0.7	2.6
Pavlov. Cond. latency score	2.5	3.2	5.5	-2.3	-1.7	-1.7	1.6	-0.8	2.2
Pavlov. Cond. lever contacts	2.1	2.5	4.8	-2.2	-1.3	-1.5	1.4	-0.6	2.1
Pavlov. Cond. magazine entry number	3.3	4.2	8.4	2.5	1.9	1.9	-1.8	0.1	-2.9
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.8	-0.6	-1.3	-0.8	1.7	-1.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.5	7.5	-2.7	-1.9	-2.1	1.8	-0.7	2.7
Pavlov. Cond. response bias	5.4	6.8	14.2	-3.2	-2.2	-2.7	1.9	-0.1	3.8
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.9	0.8	0.8	-0.8	0.3	-0.4
Pavlov. Cond. magazine entry latency	1.9	2.7	4.4	1.8	2.1	1.6	-1.5	0.5	-1.9
Pavlov. Cond. change in total contacts	0.2	0.4	1.3	-0.6	-0.7	-0.4	1.1	-0.3	0.0
Pavlov. Cond. index score	0.0	0.1	0.3	-0.1	0.2	0.1	0.1	-0.2	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.4	0.1	0.4	0.2	-0.1	-0.1	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.7	-0.8	-0.7	0.7	-0.1	0.5
Pavlov. Cond. magazine entry number	3.1	4.0	6.0	-2.1	-2.5	-1.9	2.2	-1.2	1.8
Pavlov. Cond. intertrial magazine entries	7.9	17.3	24.3	-4.6	-4.9	-4.4	4.5	-3.2	2.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.1	0.3	0.2	-0.1	-0.1	-0.6
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.1	0.0	-0.2	0.1	0.1	-0.1
Time in closed arm before self-admin	0.0	0.0	0.1	0.0	0.2	0.2	-0.3	-0.0	-0.3
Time in closed arm after self-admin	0.9	1.0	1.9	1.0	1.1	1.0	-1.4	0.3	-1.0
Time in open arm before self-admin	0.9	1.1	2.4	1.0	1.1	0.4	-1.5	-0.1	-1.2
Time in open arm after self-admin	0.3	0.4	0.8	-0.2	-0.5	-0.2	0.9	-0.9	-0.6
Bone: periosteal estimation	7.2	17.0	26.7	-5.2	-4.4	-5.0	3.5	-3.3	2.8
Bone: periosteal perimeter	4.2	8.4	14.9	-3.5	-2.8	-3.9	2.1	-3.1	1.2
Bone: post-yield work	1.0	1.7	4.4	-1.6	-0.9	-1.3	0.7	-2.1	-0.2
Progressive ratio test 1 active lever presses	1.8	3.2	4.7	-2.1	-2.2	-1.9	1.8	-1.6	0.8
Progressive ratio test 1 breakpoint	2.2	3.7	5.3	-2.3	-2.3	-2.1	2.0	-1.6	1.0
Progressive ratio test 1 inactive lever presses	1.5	4.0	6.1	-2.3	-2.5	-2.2	2.0	-1.7	0.9
Progressive ratio test 2 active lever presses	4.6	6.5	8.7	-2.9	-2.9	-2.8	2.6	-2.5	0.8
Progressive ratio test 2 breakpoint	5.4	6.9	9.1	-3.0	-3.0	-2.8	2.7	-2.8	0.6
Progressive ratio test 2 inactive lever presses	1.2	3.9	6.3	-2.1	-2.5	-2.2	1.9	-1.8	0.8
Incentive Sensitization - Responses	1.5	4.1	6.2	-2.2	-2.2	-2.2	2.0	-2.5	0.0
Incentive Sensitization - Breakpoint	1.8	4.0	6.5	-2.2	-2.1	-2.1	2.0	-2.5	-0.1
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.1	0.8	0.6	1.1	-0.2	0.0	-0.6
Progressive ratio	0.1	0.2	0.6	-0.1	-0.4	-0.1	0.8	-0.5	-0.0
Food seeking constrained by brief footshock	2.0	2.5	4.0	-1.6	-1.8	-1.1	2.0	-1.9	-0.2
Seeking ratio, punishment vs. effort	0.4	0.9	1.5	-1.2	-1.2	-1.1	0.8	-0.9	0.1
Retroperitoneal fat weight	0.4	1.8	2.5	-1.5	-1.6	-1.4	1.3	-0.8	1.3
Reaction time number correct	0.1	0.4	1.2	0.7	0.7	0.5	-1.1	0.2	-0.4
Reaction time mean minus median	0.0	0.2	0.4	0.6	0.6	0.3	-0.5	0.3	-0.0
Reaction time mean minus median AUC	0.2	1.3	2.0	1.4	1.3	1.1	-1.2	1.2	-0.1
Reaction time num false alarms	2.6	4.5	6.3	-2.4	-2.4	-2.5	2.0	-2.1	1.0
Reaction time num false alarms AUC	2.2	5.0	7.4	-2.5	-2.5	-2.7	2.1	-1.9	1.5
Reaction time trials correct on left	0.1	0.4	1.2	0.7	0.7	0.5	-1.1	0.2	-0.4
Reaction time trials on left	0.1	0.4	1.2	0.6	0.7	0.5	-1.1	0.2	-0.3
Reaction time mean	0.6	1.4	3.3	1.1	1.2	0.9	-1.1	1.8	0.6
Reaction time mean AUC	0.8	1.8	4.0	1.3	1.4	1.3	-1.2	2.0	0.5
Median of all reaction times	1.0	1.5	4.1	1.1	1.2	1.0	-1.1	2.0	0.7
Reaction time omissions	0.5	0.8	2.5	-0.5	-0.5	-1.2	0.2	0.7	1.6
Reaction time false alarm rate	3.3	4.5	5.9	-2.4	-2.4	-2.4	2.2	-1.8	1.3
Reaction time premature initiation rate	0.8	1.2	2.1	-1.1	-1.4	-1.3	1.2	-0.8	0.6
Reaction time premature initiations	0.2	0.6	1.2	-0.7	-1.1	-1.0	0.7	-0.7	0.4
Std. dev. reaction times	0.2	0.6	1.3	0.8	0.9	0.5	-0.7	1.1	0.6
Reaction time trials completed	0.1	0.4	1.2	0.6	0.7	0.5	-1.1	0.2	-0.3
Reaction time trials AUC	0.1	0.5	1.3	0.7	0.8	0.5	-1.1	0.2	-0.3
Run reversals in cocaine runway, females	0.1	0.1	0.5	0.1	-0.1	-0.3	0.1	-0.5	-0.7
Run reversals in cocaine runway, males	0.1	0.1	0.4	0.1	0.2	-0.2	-0.2	-0.6	-0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.4	0.5	0.0	-0.5	0.2	-0.3
Latency to leave start box in cocaine runway, F	0.4	0.5	1.2	0.5	0.9	0.3	-1.1	-0.3	-0.8
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.0	-0.3	-0.2	0.5	0.6	0.6
Std. dev. time between licks in bursts	0.0	0.1	0.2	0.1	0.3	0.5	-0.1	-0.2	-0.4
Total sessions with >9 infusions	0.3	0.4	1.4	-0.4	-0.6	-0.4	0.3	-1.2	-0.5
Short access day 1 total inactive lever presses	1.3	2.5	4.2	-1.9	-1.9	-2.1	1.0	-1.6	0.8
Short access day 10 total inactive lever presses	0.1	0.5	0.8	-0.6	-0.9	-0.8	0.7	-0.1	0.6
Short access day 1 total infusions	0.3	0.6	1.2	-0.8	-1.1	-0.7	0.6	-0.8	0.3
Short access day 10 total infusions	1.9	3.1	5.1	-2.0	-2.2	-1.8	1.4	-2.0	0.5
Short access total infusions	1.2	1.7	3.0	-1.6	-1.7	-1.4	1.1	-1.2	0.6
Short access day 1 locomotion	1.6	2.7	4.9	-1.7	-1.9	-1.6	1.5	-2.2	0.3
Short access day 10 total locomotion	1.5	6.0	9.2	-2.8	-3.0	-2.5	2.6	-2.3	1.0
Short access total locomotion	2.3	3.4	5.0	-2.0	-2.2	-1.8	1.8	-2.2	0.3
One hour access (0.3 mA shock)	1.2	1.4	3.1	-1.3	-1.2	-1.0	1.0	-1.7	-0.3
Compulsive drug intake	0.4	0.6	1.2	0.9	1.0	0.5	-1.1	0.4	-0.6
One hour access (shock baseline)	0.6	1.7	2.5	-1.5	-1.5	-0.9	1.6	-1.4	0.3
Social response proportion	0.9	1.1	2.9	0.6	0.7	0.7	-0.6	-1.4	-1.7
Social responses	0.2	0.3	1.0	-0.1	-0.1	-0.0	0.4	-1.0	-0.8
Social time	0.6	1.0	3.8	-0.2	-0.1	-0.2	-0.1	-1.9	-1.4
Soleus weight	0.3	1.0	2.6	-0.8	-0.5	-1.2	0.6	-1.6	-0.7
Bone: stiffness	0.2	0.3	0.6	-0.8	-0.4	-0.5	0.5	-0.6	0.4
Tibialis anterior weight	0.5	1.9	5.1	-0.1	-0.5	-0.4	1.5	-2.3	-1.9
Time to tail flick, vehicle, before self-admin	0.2	0.3	1.1	0.1	0.6	-0.4	-1.0	0.2	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	-0.3	-0.6	-0.5	0.4	0.1	0.4
Time to tail flick, test, before self-admin	0.3	0.4	0.9	0.5	0.5	0.8	-0.6	0.0	-0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.4	0.4	0.5
Delta time to tail flick, vehicle, before/after SA	1.3	1.4	2.9	-1.1	-1.6	-0.8	1.7	-0.3	0.9
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	-0.2	-0.2	-0.4	0.6	0.7	1.0
Tibia length	0.1	0.3	0.8	-0.1	0.4	-0.7	-0.9	0.2	0.3
Ambulatory time before self-admin	0.1	0.3	1.1	-0.0	0.3	-0.0	-1.1	-0.5	-0.7
Ambulatory time after self-admin	0.1	0.2	0.8	-0.1	0.3	-0.1	-0.9	-0.3	-0.4
Bone: tissue strength	1.7	1.8	2.6	1.3	1.6	1.6	-1.6	0.8	-0.8
Total heroin consumption	0.3	0.3	0.7	-0.8	-0.5	-0.4	0.1	0.2	0.8
Bone: trabecular number	2.5	4.7	12.7	-2.3	-1.7	-2.4	0.9	0.9	3.6
Bone: trabecular spacing	1.4	2.0	5.8	1.3	0.8	1.7	-0.5	-1.0	-2.4
Bone: trabecular thickness	3.5	4.9	9.4	-2.6	-1.9	-3.0	1.0	-0.3	3.1
Bone: trabecular tissue density	0.7	1.2	2.1	1.1	1.1	1.1	-1.1	1.4	0.3
Water consumed over 24 hours	0.0	0.1	0.3	-0.3	-0.2	-0.4	0.2	0.0	0.5
Number of responses in last shaping day	0.4	0.5	0.8	-0.7	-0.7	-0.9	0.9	-0.6	0.2