Hub : Genes

Tanc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio XM_006234204.4 0.04 0.03 8.3e-05 0.02 0.02 0.03 0.03 6.2e-03 1.8e-03 2.7e-04 5.0e-04
2 NAcc intron excision ratio chr3_64542849_64597573 0.02 0.01 4.3e-03 0.01 0.01 0 0.01 1.7e-02 2.1e-02 5.3e-02 2.6e-02
3 NAcc mRNA stability Tanc1 0.02 0.02 1.6e-03 0.02 0.01 0.01 0.01 1.3e-03 6.8e-03 3.0e-03 3.1e-03
4 Adipose intron excision ratio chr3_64508239_64542743 0.06 0.05 1.5e-05 0.04 0.03 0.03 0.03 8.4e-05 1.7e-04 3.4e-04 2.8e-04
5 pVTA mRNA stability Tanc1 0.04 0.03 3.4e-03 0.02 0.02 0.03 0.02 5.6e-03 6.2e-03 2.0e-03 6.3e-03
6 Adipose intron excision ratio chr3_64687471_64688370 0.04 0.03 2.3e-05 0.03 0.02 0.02 0.02 7.0e-04 9.8e-04 1.1e-03 4.7e-03
7 Adipose intron excision ratio chr3_64687492_64688370 0.04 0.03 2.5e-05 0.03 0.02 0.02 0.02 7.8e-04 1.1e-03 1.1e-03 4.7e-03
8 Brain isoform ratio XM_006234204.4 0.03 0.02 2.4e-03 0.02 0.02 0.01 0.02 5.8e-03 3.8e-03 3.9e-02 8.6e-03
9 Adipose isoform ratio NM_001002854.1 0.04 0.03 7.7e-05 0.03 0.03 0.03 0.03 3.2e-04 1.0e-04 6.1e-04 4.0e-04
10 Adipose isoform ratio XM_017591681.3 0.04 0.03 5.3e-05 0.01 0.03 0.03 0.02 9.5e-03 4.7e-04 4.8e-04 1.6e-03
11 IL gene expression Tanc1 0.38 0.23 7.7e-06 0.13 0.16 0.14 0.18 4.5e-04 9.2e-05 3.9e-04 4.3e-05
12 Adipose alternative polyA XM_063283615.1 0.06 0.04 1.4e-07 0.05 0.06 0.05 0.05 3.3e-06 7.4e-07 5.1e-06 3.1e-06
13 Adipose alternative polyA NM_001002854.1 0.06 0.04 8.0e-08 0.05 0.06 0.05 0.05 1.8e-06 3.8e-07 1.1e-06 1.5e-06
14 PL gene expression Tanc1 0.06 0.04 3.5e-07 0.06 0.06 0.05 0.05 8.3e-07 9.3e-07 1.8e-06 1.6e-06
15 Adipose isoform ratio XM_063283616.1 0.03 0.03 1.8e-04 0.03 0.03 0.02 0.02 1.7e-04 5.3e-04 1.5e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.52.64.4-1.9-1.3-1.3-1.2-1.60.9-0.9-1.7-1.71.7-1.71.8-1.8-2.12.0
Area under the delay curve0.40.40.70.60.50.30.60.5-0.60.60.70.7-0.70.9-0.80.80.7-0.7
BMI with tail0.10.30.60.60.50.50.50.6-0.40.40.60.6-0.60.8-0.70.70.6-0.6
BMI without tail0.00.10.4-0.1-0.6-0.6-0.6-0.30.5-0.5-0.2-0.10.10.2-0.10.10.3-0.3
Body weight0.00.10.2-0.2-0.4-0.4-0.4-0.40.4-0.4-0.3-0.20.2-0.20.2-0.2-0.20.2
Weight adjusted by age0.20.30.70.50.50.50.70.4-0.80.80.50.5-0.50.5-0.50.40.2-0.1
Bone surface2.13.96.0-2.3-1.3-1.3-1.3-1.91.1-1.1-2.1-2.22.2-2.32.4-2.4-2.52.4
Bone volume1.73.04.9-2.0-1.2-1.2-1.2-1.70.8-0.8-1.8-1.91.9-1.92.0-2.0-2.22.2
Breakpoint value in progressive ratio session0.30.41.40.70.00.10.20.4-0.30.30.50.5-0.50.7-0.60.71.1-1.2
Number of licking bursts0.30.50.70.80.60.70.80.8-0.70.70.70.7-0.70.8-0.70.70.8-0.8
Context. condit. distance diff. score0.30.40.90.51.01.00.90.5-1.01.00.40.3-0.30.3-0.10.10.3-0.2
Locomotion velocity, session 10.00.00.10.00.00.00.10.10.1-0.10.10.1-0.1-0.2-0.10.1-0.40.2
Locomotion distance, session 11.31.72.7-1.3-1.2-1.2-1.4-1.21.3-1.3-1.2-1.11.1-1.51.1-1.1-1.61.5
Locomotion velocity, session 20.00.00.10.20.00.0-0.10.1-0.00.00.20.2-0.20.1-0.20.20.0-0.1
Locomotion distance, session 22.53.54.5-1.9-2.0-2.0-2.1-1.82.0-2.0-1.7-1.71.7-2.01.6-1.6-1.91.8
Locomotion velocity, session 30.20.20.4-0.5-0.1-0.1-0.1-0.40.1-0.1-0.4-0.50.5-0.50.6-0.6-0.70.6
Locomotion distance, session 30.60.71.2-0.9-0.5-0.5-0.5-0.70.6-0.6-0.8-0.80.8-0.90.9-0.9-1.11.1
Stereotopy head waving bouts, day 33.64.25.4-2.1-2.3-2.3-2.3-2.12.3-2.3-2.0-2.02.0-1.91.9-1.8-1.51.6
Stereotopy head waving duration, day 33.74.46.7-2.2-2.4-2.4-2.5-2.12.6-2.6-2.0-1.91.9-1.91.8-1.8-1.51.6
Locomotion velocity, session 70.00.00.2-0.3-0.2-0.2-0.0-0.20.0-0.0-0.1-0.10.1-0.20.1-0.1-0.40.5
Locomotion distance, session 70.40.50.8-0.8-0.9-0.9-0.8-0.70.4-0.4-0.6-0.60.6-0.50.5-0.5-0.80.8
Stereotopy head waving bouts, day 70.20.30.6-0.5-0.4-0.4-0.3-0.40.8-0.8-0.4-0.40.5-0.60.5-0.5-0.40.4
Stereotopy head waving duration, day 70.50.61.1-0.7-0.5-0.5-0.5-0.61.0-1.0-0.7-0.70.7-1.00.7-0.7-0.80.8
Locomotion velocity, session 80.00.10.20.1-0.3-0.3-0.1-0.1-0.20.2-0.0-0.0-0.00.3-0.10.10.4-0.4
Locomotion distance, session 80.10.20.5-0.5-0.3-0.3-0.4-0.40.0-0.0-0.5-0.50.5-0.50.5-0.5-0.70.6
Degree of sensitization distance0.10.10.20.3-0.0-0.0-0.00.2-0.30.30.30.4-0.40.4-0.50.50.3-0.4
Degree of sensitization stereotypy0.10.10.30.40.50.50.50.5-0.10.10.40.4-0.40.3-0.40.40.3-0.4
Conditioned locomotion0.60.71.40.71.11.01.00.8-1.21.20.70.7-0.60.6-0.50.50.5-0.6
Cocaine response after cond. corrected0.20.20.60.60.0-0.0-0.00.3-0.10.10.40.5-0.50.6-0.60.60.8-0.8
Cocaine response after cond. not corrected0.10.10.40.1-0.5-0.5-0.6-0.10.4-0.40.00.1-0.10.3-0.30.30.3-0.4
Cocaine response before conditioning0.30.30.5-0.6-0.6-0.6-0.7-0.50.7-0.7-0.5-0.40.4-0.50.4-0.4-0.60.6
Saline control response0.20.20.60.30.60.50.60.4-0.80.80.40.4-0.40.4-0.30.30.0-0.0
Bone: connectivity density2.64.06.0-2.2-1.6-1.6-1.5-2.01.5-1.5-2.1-2.12.1-2.22.2-2.2-2.42.3
Bone: cortical apparent density0.10.10.3-0.3-0.6-0.5-0.5-0.40.5-0.5-0.3-0.30.20.00.2-0.20.2-0.2
Bone: cortical area1.82.85.0-1.9-1.4-1.4-1.4-1.61.3-1.3-1.6-1.61.6-1.81.7-1.7-2.22.2
Bone: cortical porosity0.10.10.50.10.70.60.60.4-0.30.30.20.2-0.2-0.3-0.10.1-0.20.3
Bone: cortical porosity0.40.51.3-0.70.0-0.1-0.0-0.40.4-0.4-0.5-0.60.6-1.10.7-0.7-1.11.1
Bone: cortical thickness0.71.22.1-1.2-1.1-1.0-1.0-1.01.1-1.1-1.0-0.91.0-1.20.9-0.9-1.41.5
Bone: cortical thickness3.44.05.2-2.3-2.0-2.0-1.9-2.11.7-1.7-2.0-2.12.1-1.92.1-2.1-1.91.9
Bone: cortical tissue density0.10.10.3-0.3-0.6-0.5-0.5-0.40.6-0.6-0.3-0.30.30.00.2-0.20.2-0.2
Condit. Reinf. active minus inactive responses3.53.94.9-2.1-2.1-2.1-2.1-2.02.2-2.2-1.9-1.91.9-1.91.8-1.8-1.81.8
Condit. Reinf. active-inactive response ratio4.04.35.9-2.2-2.2-2.2-2.2-2.02.4-2.4-2.0-1.91.9-2.11.9-1.9-2.01.8
Condit. Reinf. active responses1.41.82.9-1.4-1.6-1.6-1.6-1.31.7-1.7-1.2-1.21.2-1.11.1-1.0-0.90.9
Condit. Reinf. inactive responses0.00.10.2-0.0-0.3-0.3-0.3-0.00.2-0.20.10.1-0.10.3-0.20.20.5-0.4
Incentive salience index mean2.32.83.5-1.8-1.7-1.7-1.6-1.61.9-1.9-1.6-1.61.6-1.71.6-1.6-1.61.6
Condit. Reinf. lever presses0.00.00.10.10.10.10.10.20.3-0.30.10.1-0.10.1-0.20.20.3-0.3
Condit. Reinf. active minus inactive responses0.00.00.10.00.30.30.20.2-0.10.10.10.1-0.1-0.0-0.10.1-0.30.2
Condit. Reinf. active-inactive response ratio0.10.10.4-0.20.0-0.0-0.20.00.3-0.3-0.0-0.00.0-0.40.0-0.0-0.60.6
Condit. Reinf. active responses0.10.10.2-0.5-0.3-0.3-0.3-0.30.3-0.3-0.3-0.40.3-0.30.3-0.3-0.40.4
Condit. Reinf. inactive responses0.00.00.0-0.2-0.1-0.20.0-0.2-0.20.2-0.2-0.20.20.20.2-0.20.2-0.1
Condit. Reinf. lever presses0.40.60.9-0.9-0.9-0.9-0.9-0.80.6-0.6-0.8-0.80.7-0.50.7-0.7-0.50.5
Condit. Reinf. lever reinforcers received0.00.00.0-0.00.10.00.10.0-0.20.20.00.0-0.00.2-0.00.00.0-0.1
Conditioned reinforcement - actives2.54.24.8-2.1-2.2-2.2-1.8-2.21.8-1.8-2.0-2.02.0-2.12.0-2.0-2.22.2
Conditioned reinforcement - inactives0.40.50.80.90.60.40.60.7-0.50.50.80.8-0.80.7-0.90.90.8-0.8
Conditioned locomotion0.00.00.10.1-0.3-0.3-0.2-0.10.2-0.20.00.1-0.1-0.1-0.20.2-0.0-0.1
Patch foraging indifference point 0 sec1.22.14.2-1.5-2.0-2.1-1.7-1.71.4-1.4-1.5-1.51.4-0.91.3-1.3-0.80.8
Patch foraging indifference point AUC1.52.23.71.41.91.91.61.6-1.81.81.51.4-1.41.2-1.21.21.1-1.0
Delay disc. indifference point, 0s delay0.20.20.90.2-0.2-0.5-0.20.0-0.20.20.20.2-0.31.0-0.50.50.9-0.9
Delay disc. indifference point, 16s delay0.00.00.1-0.0-0.1-0.10.1-0.20.0-0.00.10.1-0.10.1-0.10.1-0.20.3
Delay disc. indifference point, 2s delay0.50.50.80.70.90.60.80.8-0.70.70.70.7-0.70.7-0.70.70.7-0.7
Delay disc. indifference point, 24s delay0.00.00.10.20.20.20.30.2-0.30.30.20.2-0.20.1-0.20.20.1-0.1
Delay disc. indifference point, 4s delay0.10.10.20.30.1-0.00.10.10.2-0.20.20.3-0.30.1-0.40.40.2-0.3
Delay disc. indifference point, 8s delay0.10.20.30.30.30.20.30.4-0.40.40.40.4-0.40.5-0.50.50.5-0.6
Indifference point function ln k1.83.14.0-2.0-1.8-1.8-1.9-1.91.8-1.8-1.8-1.81.7-1.61.7-1.7-1.71.7
Indifference point function log k1.83.14.0-2.0-1.8-1.8-1.9-1.91.8-1.8-1.8-1.81.7-1.61.7-1.7-1.71.7
Patch foraging total patch changes 0 sec0.81.63.2-1.2-1.7-1.8-1.5-1.51.2-1.2-1.3-1.31.2-0.71.1-1.1-0.70.7
Patch foraging total patch changes 12 sec0.00.00.20.10.40.20.30.2-0.40.40.10.0-0.00.00.0-0.1-0.00.1
Patch foraging total patch changes 18 sec0.10.20.4-0.4-0.4-0.6-0.5-0.60.1-0.1-0.5-0.60.6-0.20.6-0.6-0.10.2
Patch foraging total patch changes 24 sec0.30.40.7-0.6-0.7-0.8-0.7-0.70.9-0.9-0.6-0.60.6-0.60.6-0.6-0.40.4
Patch foraging total patch changes 6 sec0.00.00.1-0.0-0.3-0.3-0.1-0.2-0.30.3-0.1-0.20.10.30.1-0.10.2-0.2
Patch foraging time to switch 0 sec0.30.60.70.80.80.70.80.8-0.60.60.70.7-0.70.8-0.70.70.8-0.8
Patch foraging water rate 0 sec2.24.66.4-2.2-2.5-2.4-2.4-2.22.2-2.2-2.1-2.12.1-2.02.0-2.0-1.81.8
Patch foraging water rate 12 sec4.18.613.8-3.0-3.7-3.5-3.4-3.13.1-3.1-3.0-2.92.9-2.32.7-2.7-2.12.0
Patch foraging water rate 18 sec2.74.18.1-1.9-2.8-2.5-2.6-2.12.4-2.4-2.0-1.91.8-1.61.6-1.6-1.21.1
Patch foraging water rate 24 sec1.01.42.4-1.2-1.5-1.3-1.5-1.21.1-1.1-1.2-1.21.1-0.91.1-1.1-0.80.8
Patch foraging water rate 6 sec2.84.15.8-2.1-2.4-2.3-2.3-2.12.3-2.3-1.9-1.91.9-1.71.8-1.8-1.61.6
Seeking ratio, delayed vs. immediate footshock0.60.71.2-0.9-0.8-0.8-1.1-0.80.8-0.8-0.9-0.90.9-0.70.9-0.9-0.50.5
Distance traveled before self-admin2.83.67.8-1.6-2.5-2.5-2.8-1.92.4-2.4-1.8-1.71.7-1.51.4-1.4-0.70.5
Distance traveled after self-admin3.34.16.8-2.0-2.4-2.3-2.6-2.02.4-2.4-2.0-1.91.9-1.81.7-1.7-1.51.3
Extensor digitorum longus weight1.66.28.1-2.8-2.4-2.4-2.8-2.32.6-2.6-2.5-2.52.5-2.32.4-2.4-2.32.4
Bone: elastic displacement0.10.10.50.0-0.2-0.2-0.2-0.10.1-0.1-0.0-0.10.00.30.0-0.00.7-0.6
Bone: elastic work2.53.34.2-2.0-1.9-1.9-1.8-2.01.5-1.5-2.0-2.02.0-1.62.0-2.0-1.31.4
Bone: endosteal estimation0.20.40.8-0.8-0.4-0.4-0.4-0.6-0.10.1-0.7-0.80.8-0.60.8-0.9-0.80.9
Bone: endosteal perimeter0.30.61.5-0.9-0.6-0.6-0.7-0.70.3-0.3-0.7-0.80.8-0.60.8-0.8-1.01.2
Epididymis fat weight2.06.911.12.53.03.03.22.5-3.33.32.52.4-2.42.6-2.22.12.0-1.8
Delta time in closed arm before/after self-admin2.42.32.61.61.51.51.41.4-1.61.61.51.5-1.51.6-1.51.51.5-1.4
Delta time in open arm before/after self-admin0.00.00.1-0.1-0.3-0.3-0.1-0.1-0.30.3-0.1-0.10.10.30.0-0.00.1-0.1
Diff in mean of infusions in LGA sessions0.81.01.31.10.90.91.11.0-0.90.91.01.0-1.00.9-1.01.01.0-1.1
Delay discount exponential model param0.30.40.5-0.6-0.4-0.3-0.6-0.50.6-0.6-0.6-0.60.7-0.70.7-0.7-0.60.6
Extinction: sum of active levers before priming0.50.51.2-0.7-1.1-1.0-1.0-0.80.6-0.6-0.7-0.70.7-0.50.6-0.5-0.40.3
Active lever presses in extinction session 60.60.61.6-0.4-1.1-1.1-1.0-0.71.3-1.3-0.6-0.50.5-0.80.4-0.3-0.40.3
Bone: final force1.52.44.7-1.8-1.1-1.1-1.0-1.50.8-0.8-1.6-1.61.6-1.81.7-1.7-2.02.2
Bone: final moment1.72.74.8-2.0-1.2-1.2-1.2-1.60.9-0.9-1.7-1.81.8-1.91.9-1.9-2.12.2
Food consumed during 24 hour testing period2.83.85.0-2.2-1.8-1.8-1.9-1.91.7-1.7-1.9-1.91.9-2.11.9-1.9-2.12.2
Glucose0.00.00.0-0.1-0.1-0.1-0.1-0.10.0-0.0-0.1-0.10.1-0.10.1-0.1-0.10.1
Heart weight5.88.910.0-3.2-2.9-2.9-3.1-3.03.2-3.2-3.0-3.03.0-3.02.9-2.9-2.82.8
Delay discount hyperbolic model param0.50.60.8-0.8-0.6-0.5-0.8-0.70.7-0.7-0.8-0.80.8-0.90.9-0.9-0.80.8
Intermittent access intake day 1-15 change0.40.70.9-1.0-0.9-0.8-0.8-0.80.9-0.9-0.9-0.90.9-0.70.9-0.9-0.70.7
Intermittent access intake escalation0.10.30.5-0.6-0.6-0.6-0.6-0.50.7-0.7-0.6-0.50.5-0.40.5-0.5-0.40.4
Intermittent access intake escalation 20.10.10.2-0.3-0.4-0.4-0.2-0.40.5-0.5-0.3-0.30.3-0.40.3-0.3-0.30.3
Intermitt. access day 1 inactive lever presses0.10.50.80.80.60.60.40.7-0.40.40.70.8-0.80.8-0.80.80.9-0.9
Intermitt. access day 15 inactive lever presses0.61.21.41.01.21.10.91.2-1.01.01.11.2-1.21.2-1.21.20.9-0.9
Intermitt. access escalation Index1.01.53.01.11.71.71.41.4-1.21.21.21.1-1.11.1-0.90.90.9-0.8
Intermittent access day 1 total infusions0.91.42.01.41.01.01.01.2-1.01.01.31.4-1.31.2-1.41.41.1-1.2
Intermittent access day 15 total infusions0.00.00.1-0.0-0.4-0.3-0.3-0.10.3-0.3-0.00.0-0.00.0-0.10.1-0.0-0.0
Intermittent access terminal intake (last 3 days)0.10.10.20.3-0.1-0.0-0.00.20.2-0.20.30.4-0.30.2-0.40.40.2-0.3
Intermittent access total infusions0.10.10.4-0.0-0.6-0.6-0.5-0.20.5-0.5-0.10.0-0.0-0.1-0.20.20.0-0.1
Intermittent access day 1 locomotion0.71.01.21.01.11.11.01.1-0.80.81.11.1-1.10.8-1.11.10.7-0.7
Intermittent access day 15 total locomotion0.10.10.4-0.2-0.4-0.4-0.4-0.20.6-0.6-0.2-0.10.2-0.60.1-0.1-0.40.4
Intermittent access total locomotion0.00.00.10.1-0.2-0.1-0.10.10.3-0.30.20.3-0.2-0.1-0.30.4-0.1-0.0
Intermittent access standard deviation0.30.71.10.90.80.80.51.0-0.30.30.91.0-0.90.7-1.01.00.8-0.9
Left kidney weight0.00.00.2-0.20.30.40.10.00.0-0.0-0.1-0.10.1-0.10.3-0.3-0.20.3
Right kidney weight0.10.51.2-0.8-0.3-0.2-0.3-0.60.6-0.6-0.6-0.70.7-0.90.8-0.8-1.01.1
Cocaine induced anxiety0.40.51.10.70.50.70.50.7-1.01.00.70.6-0.70.9-0.70.70.7-0.7
Post-drug Anxiety0.20.30.5-0.7-0.3-0.2-0.4-0.50.0-0.0-0.5-0.60.6-0.50.6-0.6-0.70.7
Baseline Anxiety2.02.34.7-1.8-0.6-0.8-0.6-1.31.1-1.1-1.5-1.61.6-1.81.8-1.8-2.12.2
Tail length0.10.30.5-0.3-0.7-0.7-0.7-0.60.7-0.7-0.5-0.40.5-0.60.4-0.4-0.20.1
Length with tail0.52.33.0-1.6-1.3-1.3-1.3-1.61.4-1.4-1.5-1.61.6-1.71.6-1.6-1.61.6
Length without tail0.92.95.1-1.9-1.0-1.0-0.9-1.61.3-1.3-1.7-1.81.8-2.02.0-2.0-2.22.3
Times rat made contact with spout3.03.44.21.91.91.71.81.9-2.02.01.91.9-1.92.0-1.91.91.5-1.4
Lifetime Intake0.30.41.0-0.2-1.0-0.9-0.9-0.51.0-1.0-0.4-0.20.3-0.30.1-0.0-0.1-0.1
Liver weight, left0.50.81.7-1.1-0.5-0.5-0.6-0.80.5-0.5-0.9-1.01.0-1.11.1-1.1-1.21.3
Liver weight, right0.91.62.3-1.5-1.4-1.5-1.2-1.50.7-0.7-1.4-1.41.4-0.91.4-1.4-1.11.1
Locomotor activity0.60.91.5-1.2-0.6-0.6-0.7-1.10.7-0.7-1.0-1.11.0-0.81.1-1.1-1.01.1
Locomotor testing distance1.42.53.0-1.7-1.5-1.4-1.6-1.71.6-1.6-1.6-1.71.7-1.41.7-1.7-1.41.4
Locomotor testing rearing0.40.80.9-1.0-0.7-0.5-0.9-0.90.9-0.9-0.9-0.90.9-0.91.0-1.0-0.80.9
Locomotion in novel chamber0.50.71.11.01.01.10.91.0-0.70.70.80.8-0.80.5-0.70.70.6-0.6
Locomotion in novel chamber post-restriction0.10.10.30.20.40.20.50.2-0.50.50.20.1-0.10.6-0.00.00.4-0.3
Fecal boli incidents, locomotor time 10.40.51.0-0.6-0.9-1.0-1.0-0.80.7-0.7-0.7-0.70.7-0.60.6-0.6-0.50.4
Change in fecal boli incidents, locomotor task0.20.20.7-0.20.80.70.50.2-0.10.1-0.0-0.10.1-0.30.3-0.3-0.40.5
Time >=10cm from walls, locomotor time 10.10.20.4-0.5-0.2-0.4-0.2-0.50.0-0.0-0.4-0.50.4-0.00.5-0.5-0.50.6
Bouts of movement, locomotor time 12.93.34.02.01.92.01.82.0-1.51.51.91.9-1.91.6-1.91.91.7-1.7
Total resting periods, locomotor time 14.34.86.02.52.42.32.02.4-1.61.62.42.4-2.31.8-2.32.32.0-2.0
Rest time, locomotor task time 14.75.87.82.52.72.82.52.5-2.22.22.62.6-2.62.3-2.52.51.7-1.7
Distance moved, locomotor task time 13.04.65.3-2.2-2.2-2.2-1.9-2.22.0-2.0-2.2-2.32.3-2.22.3-2.3-1.91.8
Vertical activity count, locomotor time 10.71.72.4-1.5-1.4-1.3-1.3-1.41.0-1.0-1.5-1.51.5-1.31.5-1.5-1.01.0
Time >=10cm from walls, locomotor time 20.40.52.40.70.0-0.10.10.4-0.60.60.40.4-0.41.0-0.50.51.5-1.5
Bouts of movement, locomotor time 21.42.23.51.41.71.71.91.5-1.71.71.51.4-1.41.4-1.31.31.2-1.1
Total resting periods, locomotor time 21.62.83.81.61.91.92.01.7-1.81.81.71.6-1.61.6-1.51.51.4-1.3
Rest time, locomotor task time 20.40.60.90.80.80.90.50.8-0.40.40.90.9-0.90.7-0.90.90.3-0.2
Distance moved, locomotor task time 20.70.91.2-1.0-1.0-0.9-0.7-1.00.8-0.8-1.0-1.11.1-1.11.1-1.1-0.80.7
Vertical activity count, locomotor time 20.10.10.2-0.3-0.2-0.2-0.0-0.2-0.20.2-0.3-0.40.4-0.20.4-0.40.1-0.1
Light reinforcement 10.61.43.01.30.50.70.61.1-0.90.91.11.2-1.21.5-1.31.31.7-1.7
Light reinforcement 20.91.41.71.21.01.10.81.3-1.01.01.21.2-1.21.2-1.31.31.3-1.3
Bone: marrow area0.20.40.8-0.8-0.3-0.3-0.4-0.6-0.10.1-0.7-0.80.8-0.50.9-0.9-0.80.9
Bone: maximum diameter1.83.36.1-2.0-1.4-1.4-1.5-1.71.2-1.2-1.8-1.81.8-2.01.9-1.9-2.42.5
Bone: maximum force0.91.63.4-1.5-0.8-0.8-0.6-1.20.5-0.5-1.3-1.31.3-1.51.5-1.5-1.81.8
Bone: maximum moment1.01.83.4-1.6-0.8-0.8-0.7-1.30.5-0.5-1.3-1.41.4-1.51.6-1.6-1.81.9
Mean time between licks in bursts0.20.41.10.61.00.91.00.7-0.60.60.60.5-0.50.2-0.40.40.2-0.2
Mean num. licks in bursts0.10.10.40.30.60.40.30.3-0.60.60.30.3-0.30.3-0.30.30.1-0.0
Cd content in liver2.83.14.6-2.0-1.3-1.3-1.2-1.61.4-1.4-1.8-1.81.8-2.11.9-1.9-2.12.1
Co content in liver2.32.63.8-1.8-1.2-1.2-0.9-1.51.2-1.2-1.7-1.71.7-2.01.8-1.9-1.91.9
Cu content in liver2.73.15.71.72.42.42.41.8-2.02.01.71.6-1.61.3-1.31.31.2-1.2
Fe content in liver0.00.00.2-0.10.10.00.2-0.10.3-0.3-0.2-0.20.2-0.40.3-0.3-0.10.1
K content in liver1.31.22.01.01.41.41.11.2-1.21.21.01.0-1.01.1-0.90.91.0-1.0
Mg content in liver0.10.10.2-0.3-0.0-0.0-0.0-0.2-0.10.1-0.3-0.40.4-0.20.4-0.4-0.20.2
Mn content in liver4.04.55.9-2.4-1.7-1.7-1.9-2.01.6-1.6-2.2-2.22.2-2.32.3-2.3-2.42.4
Na content in liver0.10.10.3-0.4-0.4-0.4-0.5-0.30.5-0.5-0.4-0.40.4-0.10.4-0.4-0.00.1
Rb content in liver0.10.20.60.30.50.50.80.3-0.60.60.20.2-0.20.1-0.10.0-0.10.1
Se content in liver0.10.20.30.40.40.40.50.4-0.50.50.40.4-0.40.3-0.40.40.4-0.3
Sr content in liver0.10.10.3-0.2-0.3-0.3-0.3-0.20.5-0.5-0.2-0.20.2-0.30.2-0.1-0.10.1
Zn content in liver0.00.00.1-0.1-0.1-0.1-0.3-0.00.1-0.1-0.1-0.10.1-0.10.1-0.0-0.10.1
Bone: minimum diameter0.30.61.6-0.9-0.6-0.5-0.6-0.70.3-0.3-0.7-0.70.7-0.70.7-0.7-1.21.3
Time in familiar zone, hab. session 10.10.10.3-0.20.20.20.2-0.3-0.10.1-0.3-0.40.4-0.20.5-0.5-0.20.2
Time in novel zone, hab. session 10.10.10.30.3-0.3-0.3-0.40.2-0.10.10.30.4-0.40.5-0.50.50.4-0.5
Total zone transitions, hab. session 10.70.91.6-1.0-1.2-1.2-1.3-1.01.0-1.0-0.9-0.90.9-0.80.8-0.8-0.80.7
Total locomotion distance, hab. session 11.01.52.1-1.2-1.4-1.4-1.4-1.21.4-1.4-1.2-1.11.1-1.11.0-1.0-1.00.9
Locomotion velocity, hab. session 10.20.30.6-0.5-0.7-0.7-0.7-0.50.8-0.8-0.4-0.40.4-0.40.3-0.3-0.30.3
Time in familiar zone, hab. session 20.00.00.1-0.1-0.2-0.2-0.2-0.30.1-0.1-0.2-0.30.3-0.00.3-0.30.2-0.2
Time in novel zone, hab. session 20.00.00.1-0.10.00.00.00.0-0.00.0-0.0-0.00.0-0.20.0-0.0-0.40.3
Total zone transitions, hab. session 22.93.74.9-2.1-1.9-1.9-1.9-1.91.9-1.9-1.8-1.81.8-2.11.8-1.8-2.22.2
Total locomotion distance, hab. session 22.73.54.9-2.0-1.8-1.8-1.8-1.81.7-1.7-1.8-1.81.8-2.01.8-1.8-2.22.2
Locomotion velocity, hab. session 21.41.93.0-1.5-1.3-1.3-1.3-1.31.2-1.2-1.3-1.31.3-1.51.3-1.3-1.71.7
Novel to familiar place preference ratio1.31.51.91.31.41.41.41.4-1.21.21.31.3-1.20.9-1.21.20.8-0.8
Novelty place preference1.51.62.01.31.41.41.41.4-1.31.31.31.3-1.31.1-1.31.30.9-0.9
Time in novel zone, NPP test1.21.31.61.21.31.31.31.2-1.31.31.21.2-1.11.0-1.11.10.8-0.8
Total zone transitions, NPP test1.72.53.3-1.6-1.6-1.6-1.7-1.51.7-1.7-1.5-1.41.4-1.81.4-1.4-1.81.7
Total locomotion distance, NPP test1.72.32.9-1.6-1.6-1.6-1.7-1.51.6-1.6-1.4-1.41.4-1.61.3-1.2-1.61.5
Locomotion velocity, NPP test1.82.53.6-1.6-1.8-1.8-1.9-1.51.8-1.8-1.4-1.31.3-1.61.2-1.2-1.71.6
Intraocular pressure1.82.63.8-1.7-1.8-1.9-1.9-1.71.7-1.7-1.6-1.61.6-1.51.5-1.5-1.01.0
Delta distance traveled before/after self-admin0.10.10.4-0.4-0.3-0.3-0.3-0.30.4-0.4-0.3-0.30.3-0.50.2-0.2-0.60.6
Delta ambulatory time before/after self-admin0.40.51.3-0.8-0.3-0.3-0.4-0.50.7-0.7-0.6-0.60.6-0.80.7-0.7-1.11.1
Parametrial fat weight1.43.34.71.82.22.02.02.0-1.91.91.81.8-1.81.8-1.71.71.4-1.4
Pavlov. Cond. lever latency2.73.43.92.01.81.81.81.9-1.91.91.91.9-1.91.9-1.91.91.7-1.8
Pavlov. Cond. magazine entry latency2.02.53.1-1.8-1.4-1.4-1.4-1.61.7-1.7-1.6-1.71.6-1.51.7-1.7-1.41.4
Pavlov. Cond. change in total contacts2.42.53.0-1.7-1.5-1.5-1.5-1.61.7-1.7-1.6-1.61.6-1.61.6-1.6-1.61.6
Pavlov. Cond. index score3.44.35.0-2.2-2.0-2.0-2.0-2.12.2-2.2-2.1-2.12.1-2.02.1-2.1-1.81.8
Pavlov. Cond. latency score4.15.26.1-2.5-2.2-2.2-2.2-2.32.4-2.4-2.3-2.32.3-2.22.3-2.3-2.12.1
Pavlov. Cond. lever contacts2.32.73.1-1.8-1.6-1.6-1.6-1.71.7-1.7-1.7-1.71.7-1.61.7-1.7-1.41.5
Pavlov. Cond. magazine entry number1.92.42.81.71.31.31.31.5-1.71.71.61.6-1.61.6-1.71.71.4-1.4
Pavlov. Cond. intertrial magazine entries0.20.20.8-0.3-0.9-0.9-0.9-0.40.4-0.4-0.3-0.20.2-0.10.1-0.0-0.20.2
Pavlov. Cond. lever-magazine prob. diff.2.32.83.6-1.8-1.6-1.6-1.6-1.71.9-1.9-1.7-1.71.7-1.61.7-1.7-1.41.4
Pavlov. Cond. response bias2.12.63.2-1.7-1.4-1.4-1.5-1.61.8-1.8-1.6-1.71.7-1.61.7-1.7-1.31.3
Pavlov. Cond. lever latency0.71.01.71.21.21.21.31.1-0.80.81.01.0-1.00.6-0.90.90.7-0.7
Pavlov. Cond. magazine entry latency3.84.66.82.41.71.71.62.1-2.02.02.12.1-2.12.4-2.22.22.5-2.6
Pavlov. Cond. change in total contacts2.13.44.7-2.0-2.0-2.0-2.2-2.01.7-1.7-1.9-1.91.9-1.61.8-1.8-1.61.6
Pavlov. Cond. index score0.10.10.4-0.2-0.5-0.6-0.6-0.30.1-0.1-0.2-0.20.10.30.1-0.00.3-0.3
Pavlov. Cond. latency score0.10.10.40.1-0.3-0.3-0.30.0-0.10.10.10.1-0.20.5-0.20.20.6-0.6
Pavlov. Cond. lever contacts1.01.42.0-1.4-1.3-1.3-1.4-1.31.0-1.0-1.2-1.21.2-0.91.2-1.2-0.90.9
Pavlov. Cond. magazine entry number0.60.82.0-1.0-0.2-0.2-0.1-0.70.4-0.4-0.8-0.90.9-1.21.1-1.1-1.31.4
Pavlov. Cond. intertrial magazine entries1.42.22.6-1.5-1.5-1.5-1.4-1.51.5-1.5-1.5-1.41.5-1.61.4-1.4-1.31.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.2-0.5-0.6-0.6-0.30.2-0.2-0.2-0.20.20.20.1-0.10.2-0.2
Pavlov. Cond. response bias0.20.20.7-0.5-0.7-0.7-0.8-0.50.4-0.4-0.5-0.50.5-0.10.4-0.4-0.20.2
Time in closed arm before self-admin0.20.21.0-0.50.30.30.3-0.10.1-0.1-0.2-0.30.3-0.50.4-0.4-0.91.0
Time in closed arm after self-admin1.21.22.21.11.51.51.31.2-1.11.11.11.1-1.10.9-1.01.00.7-0.6
Time in open arm before self-admin0.20.20.80.40.90.90.80.6-0.00.00.40.3-0.3-0.3-0.10.1-0.10.1
Time in open arm after self-admin0.40.40.7-0.7-0.8-0.8-0.7-0.70.5-0.5-0.6-0.70.7-0.50.7-0.7-0.50.5
Bone: periosteal estimation0.81.73.5-1.5-0.9-0.9-1.0-1.30.5-0.5-1.3-1.41.4-1.31.5-1.5-1.81.9
Bone: periosteal perimeter1.22.14.3-1.7-1.2-1.2-1.3-1.40.9-0.9-1.4-1.41.4-1.51.5-1.5-1.92.1
Bone: post-yield work0.40.51.20.61.01.01.10.7-1.01.00.60.6-0.60.2-0.50.5-0.30.3
Progressive ratio test 1 active lever presses0.10.10.4-0.1-0.3-0.3-0.4-0.10.6-0.6-0.1-0.00.0-0.1-0.10.1-0.0-0.1
Progressive ratio test 1 breakpoint0.10.10.4-0.1-0.3-0.3-0.4-0.10.6-0.6-0.10.0-0.0-0.2-0.10.1-0.0-0.0
Progressive ratio test 1 inactive lever presses1.42.02.41.51.51.41.31.5-1.11.11.51.5-1.51.4-1.61.61.3-1.3
Progressive ratio test 2 active lever presses1.21.41.8-1.1-1.3-1.3-1.2-1.21.3-1.3-1.1-1.11.1-1.21.0-1.0-1.21.2
Progressive ratio test 2 breakpoint1.11.31.7-1.1-1.3-1.3-1.1-1.21.3-1.3-1.0-1.01.0-1.10.9-0.9-1.11.1
Progressive ratio test 2 inactive lever presses0.10.20.8-0.1-0.6-0.7-0.8-0.30.9-0.9-0.2-0.00.0-0.2-0.10.20.0-0.2
Incentive Sensitization - Responses0.60.81.4-0.8-1.2-1.2-0.9-1.00.9-0.9-0.9-0.90.9-0.80.8-0.8-0.80.8
Incentive Sensitization - Breakpoint0.50.61.0-0.7-1.0-1.0-0.7-0.90.7-0.7-0.7-0.70.7-0.70.7-0.7-0.70.8
Sum of active levers in priming session hrs 5-60.10.10.3-0.1-0.5-0.40.0-0.60.3-0.3-0.3-0.30.3-0.30.3-0.3-0.50.5
Progressive ratio0.40.61.0-0.8-0.9-0.9-0.4-1.00.5-0.5-0.9-1.00.9-0.61.0-1.0-0.50.6
Food seeking constrained by brief footshock0.30.40.8-0.7-0.6-0.4-0.5-0.50.2-0.2-0.6-0.60.6-0.80.6-0.6-0.90.9
Seeking ratio, punishment vs. effort0.20.20.50.50.40.50.00.6-0.30.30.60.6-0.60.4-0.70.70.3-0.4
Retroperitoneal fat weight5.121.727.54.85.05.15.24.8-5.05.04.74.6-4.64.5-4.44.43.9-3.7
Reaction time number correct1.63.14.1-1.8-2.0-1.9-2.0-1.81.8-1.8-1.8-1.81.8-1.61.8-1.8-1.21.2
Reaction time mean minus median0.82.13.21.41.81.71.61.5-1.41.41.41.4-1.41.3-1.31.31.3-1.3
Reaction time mean minus median AUC2.76.88.52.72.92.82.82.7-2.52.52.62.5-2.52.5-2.42.42.6-2.6
Reaction time num false alarms4.15.87.22.42.52.62.42.5-2.72.72.52.4-2.42.3-2.42.41.8-1.8
Reaction time num false alarms AUC2.94.55.82.12.22.32.12.2-2.42.42.22.1-2.12.1-2.12.11.7-1.6
Reaction time trials correct on left1.63.14.1-1.8-2.0-1.9-2.0-1.81.8-1.8-1.8-1.81.8-1.61.8-1.8-1.21.2
Reaction time trials on left1.52.73.7-1.7-1.9-1.8-1.9-1.71.7-1.7-1.7-1.71.7-1.51.7-1.7-1.21.1
Reaction time mean5.08.09.23.03.03.02.92.8-3.03.02.82.7-2.72.8-2.62.62.7-2.6
Reaction time mean AUC4.67.49.02.92.92.82.92.7-3.03.02.72.6-2.62.7-2.52.52.5-2.4
Median of all reaction times4.96.98.22.82.62.72.72.6-2.92.92.62.5-2.52.7-2.52.42.5-2.5
Reaction time omissions3.34.86.12.22.42.52.52.3-2.32.32.22.2-2.12.0-2.02.01.8-1.8
Reaction time false alarm rate6.79.210.73.13.23.23.13.2-3.33.33.13.1-3.12.9-3.03.02.4-2.3
Reaction time premature initiation rate0.10.20.40.40.0-0.00.00.4-0.20.20.40.4-0.40.6-0.50.50.7-0.7
Reaction time premature initiations0.20.40.9-0.7-1.0-0.9-1.0-0.60.7-0.7-0.6-0.60.6-0.40.5-0.5-0.20.2
Std. dev. reaction times3.05.67.82.42.82.72.62.5-2.42.42.42.3-2.32.1-2.12.12.0-2.0
Reaction time trials completed1.52.73.7-1.7-1.9-1.8-1.9-1.71.7-1.7-1.7-1.71.7-1.51.7-1.7-1.21.1
Reaction time trials AUC1.63.04.1-1.7-2.0-1.9-2.0-1.81.8-1.8-1.8-1.81.8-1.61.7-1.7-1.21.2
Run reversals in cocaine runway, females0.40.41.1-0.6-0.6-0.5-1.1-0.40.8-0.8-0.5-0.50.5-0.40.4-0.4-0.50.4
Run reversals in cocaine runway, males0.70.71.11.00.80.80.60.8-0.30.30.91.0-1.00.8-1.01.00.7-0.7
Latency to leave start box in cocaine runway0.00.00.3-0.20.10.00.0-0.20.0-0.0-0.0-0.00.0-0.00.1-0.1-0.40.5
Latency to leave start box in cocaine runway, F0.10.10.50.10.40.40.70.1-0.60.60.20.2-0.20.4-0.10.1-0.10.2
Latency to leave start box in cocaine runway, M0.30.30.6-0.4-0.6-0.6-0.8-0.60.8-0.8-0.4-0.30.3-0.40.3-0.2-0.60.6
Std. dev. time between licks in bursts0.70.91.2-1.1-0.8-0.8-0.8-1.01.0-1.0-0.9-1.01.0-1.01.0-1.0-1.11.1
Total sessions with >9 infusions0.20.20.60.4-0.4-0.4-0.30.10.6-0.60.20.3-0.30.3-0.50.50.6-0.8
Short access day 1 total inactive lever presses0.70.92.11.30.40.20.20.90.1-0.11.01.1-1.10.8-1.31.31.3-1.5
Short access day 10 total inactive lever presses0.10.30.50.70.50.50.60.6-0.30.30.60.6-0.60.5-0.60.60.7-0.7
Short access day 1 total infusions0.30.31.2-0.0-0.8-0.9-0.9-0.41.1-1.1-0.3-0.10.1-0.1-0.00.10.3-0.4
Short access day 10 total infusions0.20.31.00.1-0.7-0.6-0.9-0.11.0-1.0-0.00.1-0.1-0.1-0.30.40.3-0.5
Short access total infusions0.40.51.6-0.2-1.1-1.0-1.1-0.51.3-1.3-0.3-0.20.2-0.2-0.00.00.2-0.3
Short access day 1 locomotion0.60.72.11.2-0.2-0.20.20.5-0.00.00.80.9-0.90.9-1.11.11.3-1.5
Short access day 10 total locomotion0.00.00.1-0.10.0-0.0-0.30.10.3-0.3-0.10.00.0-0.1-0.00.00.0-0.1
Short access total locomotion0.50.51.00.90.40.50.30.8-0.20.20.80.9-0.80.7-1.01.00.9-1.0
One hour access (0.3 mA shock)1.41.62.1-1.4-1.2-1.2-1.2-1.11.4-1.4-1.2-1.21.2-1.41.2-1.2-1.21.2
Compulsive drug intake0.81.01.70.91.31.31.30.9-1.31.30.90.8-0.81.0-0.70.70.8-0.7
One hour access (shock baseline)1.42.23.2-1.5-1.6-1.5-1.7-1.31.8-1.8-1.4-1.41.4-1.51.3-1.3-1.31.3
Social response proportion0.80.91.60.71.01.00.70.9-1.01.00.90.9-0.91.3-0.90.90.9-0.8
Social responses0.10.10.30.1-0.1-0.0-0.20.10.0-0.00.20.2-0.20.5-0.30.30.5-0.5
Social time1.41.92.21.41.31.51.41.5-1.31.31.51.5-1.51.5-1.51.51.1-1.1
Soleus weight0.10.31.2-0.2-0.7-0.7-1.1-0.20.5-0.5-0.2-0.20.10.4-0.00.10.8-0.7
Bone: stiffness0.91.43.3-1.3-0.9-0.9-0.7-1.10.7-0.7-1.1-1.11.1-1.41.1-1.1-1.81.8
Tibialis anterior weight1.34.57.1-2.4-2.4-2.4-2.7-2.12.2-2.2-2.2-2.12.1-1.62.0-2.0-1.51.7
Time to tail flick, vehicle, before self-admin3.13.24.01.72.02.02.02.0-1.81.81.81.8-1.81.8-1.81.81.4-1.4
Time to tail flick, vehicle, after self-admin1.01.31.91.20.90.91.10.9-1.41.41.11.1-1.11.4-1.21.21.3-1.2
Time to tail flick, test, before self-admin0.10.10.4-0.0-0.4-0.4-0.4-0.20.6-0.6-0.10.00.0-0.4-0.10.1-0.20.1
Time to tail flick, test, after self-admin0.00.00.1-0.0-0.2-0.2-0.4-0.20.1-0.1-0.1-0.00.00.1-0.00.0-0.00.0
Delta time to tail flick, vehicle, before/after SA1.21.12.2-0.9-1.5-1.5-1.3-1.41.0-1.0-1.1-1.01.0-0.80.9-0.9-0.70.7
Delta time to tail flick, test, before/after SA0.10.10.40.10.40.40.30.1-0.60.60.20.1-0.10.5-0.00.00.00.1
Tibia length1.23.45.3-1.8-1.7-1.6-1.4-1.81.9-1.9-1.8-1.81.9-2.31.9-1.9-2.01.9
Ambulatory time before self-admin1.52.35.7-1.2-2.1-2.1-2.4-1.42.0-2.0-1.4-1.31.3-1.11.0-1.0-0.30.1
Ambulatory time after self-admin2.53.05.9-1.6-2.1-2.1-2.4-1.72.2-2.2-1.7-1.51.5-1.51.3-1.3-1.00.8
Bone: tissue strength0.20.20.5-0.4-0.6-0.7-0.7-0.50.2-0.2-0.4-0.40.30.20.3-0.30.3-0.2
Total heroin consumption0.10.10.40.4-0.2-0.10.20.0-0.30.30.10.1-0.10.5-0.10.10.6-0.6
Bone: trabecular number2.84.66.2-2.4-1.9-1.9-1.8-2.11.7-1.7-2.2-2.22.2-2.32.3-2.3-2.52.4
Bone: trabecular spacing5.16.88.22.92.32.32.22.7-2.22.22.72.8-2.82.8-2.92.92.7-2.7
Bone: trabecular thickness0.60.81.2-1.0-0.8-0.8-0.6-1.00.5-0.5-1.0-1.11.0-0.81.1-1.1-0.90.9
Bone: trabecular tissue density0.81.11.31.01.01.00.91.1-0.90.91.11.1-1.11.2-1.11.11.1-1.1
Water consumed over 24 hours0.30.40.8-0.8-0.6-0.7-0.6-0.60.3-0.3-0.6-0.60.6-0.50.6-0.6-0.90.9
Number of responses in last shaping day0.60.71.1-1.0-0.8-0.9-1.1-0.80.9-0.9-0.9-0.90.8-0.60.8-0.8-0.50.5