Hub : Genes

Taco1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Taco1 0.05 0.03 1.2e-05 0.04 0.04 0.04 0.04 9.8e-06 2.0e-05 6.4e-05 4.7e-05
2 Brain mRNA stability Taco1 0.14 0.06 5.6e-17 0.18 0.17 0.18 0.18 9.2e-17 4.9e-16 1.2e-16 6.7e-17
3 NAcc mRNA stability Taco1 0.13 0.06 0.0e+00 0.15 0.14 0.14 0.15 6.9e-22 3.1e-20 3.0e-21 5.4e-22
4 LHb mRNA stability Taco1 0.18 0.09 1.6e-03 0.09 0.09 0.07 0.09 3.8e-03 3.9e-03 1.0e-02 4.4e-03
5 Liver mRNA stability Taco1 0.09 0.04 6.8e-14 0.1 0.1 0.1 0.11 1.9e-11 1.1e-11 1.3e-11 5.2e-12
6 IC mRNA stability Taco1 0.07 0.04 5.6e-03 0.05 0.05 0.02 0.01 4.1e-03 5.0e-03 5.6e-02 1.7e-01
7 Adipose mRNA stability Taco1 0.08 0.04 3.8e-08 0.06 0.07 0.05 0.06 4.1e-07 6.5e-08 5.6e-06 6.8e-07
8 pVTA mRNA stability Taco1 0.09 0.04 1.9e-08 0.12 0.11 0.1 0.12 5.0e-10 2.9e-09 1.7e-08 3.0e-10
9 Liver gene expression Taco1 0.12 0.05 2.3e-14 0.12 0.1 0.1 0.11 1.8e-13 2.3e-11 1.1e-11 8.6e-12
10 PL mRNA stability Taco1 0.1 0.04 1.9e-10 0.07 0.09 0.07 0.08 1.0e-07 7.5e-10 1.4e-08 1.0e-08
11 BLA mRNA stability Taco1 0.11 0.05 1.2e-07 0.12 0.11 0.11 0.12 6.3e-07 1.5e-06 1.4e-06 1.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.03.55.6-1.6-1.8-2.0-1.8-2.2-1.9-1.6-1.7-2.2-2.4-0.5
Area under the delay curve0.20.20.5-0.1-0.5-0.4-0.1-0.7-0.4-0.0-0.6-0.7-0.20.1
BMI with tail0.41.53.6-1.2-1.4-1.2-0.7-1.1-0.8-0.8-1.9-1.5-0.5-1.4
BMI without tail1.75.29.0-2.4-2.7-2.2-1.6-2.2-2.0-2.0-3.0-2.7-1.8-2.0
Body weight2.912.717.2-3.8-4.0-3.8-3.3-3.6-3.1-3.0-4.1-3.9-3.0-3.1
Weight adjusted by age0.81.21.81.21.01.01.10.90.91.31.11.11.30.9
Bone surface7.113.016.0-3.8-3.7-3.8-3.8-4.0-3.7-3.3-3.3-3.8-3.9-2.2
Bone volume5.910.513.4-3.2-3.3-3.5-3.4-3.7-3.3-2.9-3.1-3.6-3.5-1.8
Breakpoint value in progressive ratio session0.20.30.5-0.2-0.2-0.4-0.7-0.2-0.7-0.7-0.6-0.5-0.4-0.7
Number of licking bursts0.00.00.20.10.2-0.4-0.5-0.2-0.10.10.10.10.20.0
Context. condit. distance diff. score0.50.71.40.30.71.21.10.70.60.80.60.91.2-0.1
Locomotion velocity, session 11.92.02.9-1.6-1.4-1.7-1.6-1.3-1.6-1.3-1.1-1.3-1.7-0.6
Locomotion distance, session 10.10.10.3-0.5-0.5-0.5-0.3-0.2-0.1-0.2-0.0-0.2-0.50.4
Locomotion velocity, session 20.91.02.4-0.9-0.7-1.1-1.5-0.6-1.1-1.3-0.5-0.5-1.2-1.2
Locomotion distance, session 20.10.10.4-0.2-0.00.30.10.40.2-0.10.50.60.1-0.1
Locomotion velocity, session 30.10.10.30.50.4-0.1-0.10.40.10.40.50.40.20.6
Locomotion distance, session 30.10.10.5-0.1-0.2-0.6-0.7-0.2-0.3-0.1-0.0-0.1-0.3-0.1
Stereotopy head waving bouts, day 30.10.10.60.60.40.10.20.1-0.00.40.2-0.1-0.10.8
Stereotopy head waving duration, day 30.30.41.01.00.80.50.70.40.30.80.40.30.70.7
Locomotion velocity, session 70.30.30.70.80.60.40.40.70.30.40.60.50.30.6
Locomotion distance, session 70.20.30.70.80.50.40.40.60.50.30.50.60.60.2
Stereotopy head waving bouts, day 70.20.20.50.40.60.30.20.40.30.40.70.50.10.7
Stereotopy head waving duration, day 70.81.01.70.91.30.90.61.10.90.91.31.20.71.1
Locomotion velocity, session 80.20.31.2-0.9-0.3-0.5-0.6-0.3-0.4-0.3-0.30.00.1-1.1
Locomotion distance, session 80.20.30.6-0.10.30.70.50.50.40.20.40.80.8-0.6
Degree of sensitization distance0.10.10.40.00.10.50.60.30.40.10.00.30.6-0.2
Degree of sensitization stereotypy0.60.61.30.50.90.80.50.90.80.61.11.10.40.8
Conditioned locomotion0.20.20.9-0.0-0.3-0.2-0.1-0.4-0.0-0.6-0.7-0.4-0.1-0.9
Cocaine response after cond. corrected0.20.30.90.60.20.30.30.00.10.80.60.40.51.0
Cocaine response after cond. not corrected0.20.20.90.40.20.1-0.1-0.1-0.30.50.70.3-0.01.0
Cocaine response before conditioning0.20.20.6-0.2-0.1-0.4-0.7-0.2-0.6-0.5-0.0-0.2-0.80.0
Saline control response1.01.45.0-0.8-0.9-0.8-0.9-0.9-0.9-1.5-1.4-0.9-0.7-2.2
Bone: connectivity density2.94.56.5-2.0-2.1-2.2-2.1-2.4-2.3-2.0-1.9-2.3-2.5-1.1
Bone: cortical apparent density4.05.57.62.52.22.32.72.42.52.32.11.91.92.8
Bone: cortical area1.92.94.5-1.5-1.8-2.1-1.9-1.9-1.6-1.2-1.6-2.1-2.0-0.4
Bone: cortical porosity12.013.019.5-3.3-3.4-3.9-4.4-3.6-4.4-3.5-2.9-3.3-4.0-2.6
Bone: cortical porosity9.09.814.0-3.0-3.0-3.4-3.7-3.3-3.6-2.8-2.7-3.1-3.4-2.1
Bone: cortical thickness2.94.814.82.52.11.31.72.02.22.52.11.31.03.8
Bone: cortical thickness1.82.25.81.81.51.21.21.51.31.41.61.00.52.4
Bone: cortical tissue density3.95.37.22.52.22.32.62.42.52.22.01.81.82.7
Condit. Reinf. active minus inactive responses3.33.74.5-1.7-1.8-1.8-2.0-1.9-2.1-2.1-1.9-1.9-1.8-2.1
Condit. Reinf. active-inactive response ratio1.41.52.2-1.1-1.2-0.9-1.1-1.2-1.4-1.3-1.2-1.2-1.2-1.5
Condit. Reinf. active responses3.84.86.0-2.0-2.0-2.2-2.3-2.1-2.2-2.3-2.3-2.1-1.9-2.5
Condit. Reinf. inactive responses1.11.42.2-1.2-1.1-1.5-1.3-1.2-1.0-1.1-1.3-1.2-0.9-1.0
Incentive salience index mean3.74.65.5-2.1-2.0-2.1-2.3-2.0-2.2-2.3-2.0-2.1-2.3-2.1
Condit. Reinf. lever presses1.11.62.7-1.5-1.0-1.5-1.7-0.8-0.9-1.5-1.0-1.0-1.6-1.0
Condit. Reinf. active minus inactive responses8.010.313.0-3.0-3.3-3.3-3.5-3.6-3.5-3.1-3.1-3.2-3.1-2.7
Condit. Reinf. active-inactive response ratio5.86.78.6-2.3-2.5-2.7-2.9-2.8-2.9-2.6-2.3-2.5-2.7-2.0
Condit. Reinf. active responses8.011.213.0-3.0-3.4-3.3-3.4-3.6-3.4-3.4-3.4-3.4-3.1-3.2
Condit. Reinf. inactive responses1.62.03.3-1.1-1.5-1.3-1.3-1.4-1.1-1.6-1.7-1.5-1.1-1.8
Condit. Reinf. lever presses2.83.84.8-2.0-2.0-2.0-2.2-1.8-1.9-2.2-1.8-1.8-2.1-1.9
Condit. Reinf. lever reinforcers received7.310.212.0-2.8-3.3-3.2-3.3-3.5-3.3-3.3-3.2-3.2-3.0-3.0
Conditioned reinforcement - actives0.30.51.0-1.0-0.9-0.7-0.6-0.7-0.6-0.6-0.5-0.3-0.4-0.9
Conditioned reinforcement - inactives0.91.42.0-1.4-1.3-1.2-1.1-1.1-1.4-1.1-1.0-1.0-1.2-0.9
Conditioned locomotion3.24.15.4-2.3-2.3-2.0-1.9-2.1-2.2-2.1-1.7-1.7-2.0-2.0
Patch foraging indifference point 0 sec3.15.77.6-2.1-2.5-2.3-2.1-2.7-2.3-2.4-2.7-2.5-2.0-2.3
Patch foraging indifference point AUC0.50.71.4-1.2-1.0-0.5-0.4-0.8-0.7-0.7-1.0-0.7-0.4-1.1
Delay disc. indifference point, 0s delay0.40.41.01.00.70.50.70.30.60.80.30.30.80.7
Delay disc. indifference point, 16s delay0.60.61.3-0.3-0.9-0.9-0.6-1.2-0.8-0.4-1.0-1.1-0.5-0.4
Delay disc. indifference point, 2s delay0.60.71.8-0.7-0.9-0.8-0.5-1.3-0.8-0.4-1.1-1.2-0.6-0.2
Delay disc. indifference point, 24s delay1.31.52.1-1.2-1.4-1.4-1.0-1.4-1.1-0.9-1.4-1.4-0.9-1.0
Delay disc. indifference point, 4s delay0.20.30.70.80.50.30.40.20.10.70.60.30.20.9
Delay disc. indifference point, 8s delay0.10.10.30.2-0.2-0.10.2-0.2-0.10.2-0.3-0.5-0.20.6
Indifference point function ln k0.10.21.00.90.4-0.4-0.30.00.10.20.2-0.1-0.11.0
Indifference point function log k0.10.21.00.90.4-0.4-0.30.00.10.20.2-0.1-0.11.0
Patch foraging total patch changes 0 sec3.36.38.4-2.2-2.7-2.5-2.2-2.9-2.4-2.5-2.9-2.7-2.1-2.3
Patch foraging total patch changes 12 sec3.64.68.3-2.5-2.3-1.7-1.7-2.2-1.8-2.4-2.3-1.8-1.5-2.9
Patch foraging total patch changes 18 sec2.23.44.3-1.8-2.0-1.6-1.6-2.0-1.9-2.0-2.0-1.7-1.5-2.1
Patch foraging total patch changes 24 sec3.05.16.7-2.2-2.6-1.9-1.8-2.6-2.4-2.2-2.5-2.5-2.1-1.9
Patch foraging total patch changes 6 sec2.53.74.5-1.7-2.1-1.9-1.8-2.1-2.0-1.9-2.1-2.0-1.7-1.8
Patch foraging time to switch 0 sec0.20.30.70.70.90.2-0.10.80.60.30.80.70.20.4
Patch foraging water rate 0 sec1.43.04.3-1.8-2.1-1.7-1.4-1.9-1.5-1.6-2.1-2.0-1.6-1.4
Patch foraging water rate 12 sec0.30.72.91.00.70.50.70.50.51.10.80.30.41.7
Patch foraging water rate 18 sec0.10.20.4-0.2-0.5-0.3-0.2-0.6-0.4-0.1-0.2-0.5-0.60.5
Patch foraging water rate 24 sec0.00.00.2-0.10.00.10.0-0.10.30.30.20.20.20.4
Patch foraging water rate 6 sec0.30.40.9-0.2-0.6-0.6-0.4-0.9-0.7-0.3-0.6-1.0-0.90.6
Seeking ratio, delayed vs. immediate footshock0.10.20.5-0.10.30.70.70.50.50.20.10.20.4-0.3
Distance traveled before self-admin0.30.31.01.00.5-0.0-0.20.10.10.80.70.40.40.9
Distance traveled after self-admin0.10.10.30.20.30.40.10.00.00.40.20.20.50.0
Extensor digitorum longus weight2.710.617.23.43.43.13.63.44.13.32.32.93.91.8
Bone: elastic displacement1.01.13.10.91.10.91.01.10.71.21.20.80.51.8
Bone: elastic work0.30.41.4-0.6-0.6-0.7-0.5-0.4-0.4-0.3-0.3-0.7-1.20.6
Bone: endosteal estimation16.135.239.3-6.3-6.2-5.8-6.1-6.1-6.1-6.1-5.7-5.4-5.4-6.0
Bone: endosteal perimeter16.936.042.0-6.5-6.3-5.9-6.1-6.5-6.1-5.7-6.0-5.6-5.1-6.1
Epididymis fat weight0.20.81.2-0.9-1.0-1.0-0.7-0.9-0.8-0.7-1.1-0.9-0.6-0.8
Delta time in closed arm before/after self-admin0.10.10.20.10.10.20.10.30.30.20.40.2-0.20.5
Delta time in open arm before/after self-admin0.30.21.00.50.50.30.50.40.50.30.10.41.0-0.0
Diff in mean of infusions in LGA sessions2.02.53.41.61.81.61.51.91.61.41.61.61.41.3
Delay discount exponential model param0.20.30.70.30.60.50.20.80.50.10.70.80.30.1
Extinction: sum of active levers before priming0.10.10.50.50.30.30.30.20.10.2-0.10.10.7-0.3
Active lever presses in extinction session 61.91.93.1-1.0-1.2-1.4-1.5-1.3-1.8-1.4-1.5-1.5-1.2-1.3
Bone: final force1.01.62.4-1.1-1.4-1.6-1.5-1.5-1.2-0.7-0.9-1.4-1.50.1
Bone: final moment1.11.82.8-1.2-1.5-1.7-1.6-1.6-1.2-0.8-1.0-1.5-1.70.1
Food consumed during 24 hour testing period1.92.64.6-2.2-1.5-1.7-1.5-1.4-1.3-1.6-1.9-1.5-1.1-1.9
Glucose1.32.13.11.51.51.21.11.41.21.81.61.51.61.4
Heart weight0.20.41.50.30.20.50.80.10.51.10.2-0.00.61.2
Delay discount hyperbolic model param0.30.30.70.30.60.50.20.90.60.20.70.80.40.1
Intermittent access intake day 1-15 change0.10.10.50.10.30.0-0.10.50.40.20.50.70.4-0.3
Intermittent access intake escalation0.10.10.6-0.4-0.2-0.4-0.5-0.0-0.0-0.2-0.00.20.1-0.8
Intermittent access intake escalation 20.20.20.9-0.6-0.3-0.5-0.7-0.2-0.2-0.5-0.2-0.0-0.2-0.9
Intermitt. access day 1 inactive lever presses1.45.36.6-2.2-2.3-2.4-2.4-2.1-2.3-2.6-2.3-2.2-2.4-2.2
Intermitt. access day 15 inactive lever presses1.53.04.9-1.2-1.7-2.0-1.8-1.5-1.9-2.2-1.5-1.6-2.2-1.3
Intermitt. access escalation Index2.23.24.31.91.91.91.71.51.52.11.81.72.01.5
Intermittent access day 1 total infusions0.81.31.9-1.4-1.2-1.2-1.2-1.2-1.3-1.0-1.0-0.8-0.9-0.8
Intermittent access day 15 total infusions1.01.42.5-1.6-1.4-1.3-1.2-1.2-1.2-1.0-1.1-0.8-0.6-1.4
Intermittent access terminal intake (last 3 days)2.22.94.8-2.2-1.9-1.8-1.7-1.7-1.7-1.6-1.5-1.1-1.2-2.0
Intermittent access total infusions2.32.75.1-2.3-1.9-1.6-1.6-1.7-1.6-1.5-1.5-1.1-1.1-1.8
Intermittent access day 1 locomotion4.55.77.6-2.8-2.6-2.3-2.3-2.4-2.7-2.3-2.3-2.2-2.4-2.0
Intermittent access day 15 total locomotion3.36.010.9-3.3-2.6-2.3-2.2-2.4-2.4-2.4-2.4-2.1-2.0-2.6
Intermittent access total locomotion7.89.315.1-3.9-3.3-2.9-2.9-3.0-3.1-3.1-2.8-2.6-2.9-3.0
Intermittent access standard deviation0.40.81.9-1.4-0.9-0.9-0.9-0.5-0.6-1.1-0.8-0.6-1.0-0.9
Left kidney weight0.00.21.30.1-0.10.00.10.00.00.60.3-0.1-0.11.1
Right kidney weight0.10.30.8-0.7-0.7-0.4-0.1-0.5-0.30.3-0.2-0.5-0.50.9
Cocaine induced anxiety0.10.21.10.40.20.40.40.20.10.40.50.1-0.21.1
Post-drug Anxiety0.40.41.70.50.40.70.70.50.40.70.50.30.01.3
Baseline Anxiety0.10.20.30.30.40.50.50.50.50.40.20.20.30.4
Tail length3.312.915.2-3.9-3.8-3.7-3.5-3.4-3.6-3.7-3.4-3.6-3.9-2.9
Length with tail2.29.814.7-3.8-3.4-3.3-3.2-3.2-2.8-2.8-3.1-3.1-2.9-2.6
Length without tail0.10.41.2-1.1-0.8-0.9-0.7-0.7-0.2-0.3-0.6-0.6-0.4-0.6
Times rat made contact with spout0.91.12.7-1.7-1.1-0.8-0.9-0.9-0.9-1.0-1.0-1.0-1.1-0.9
Lifetime Intake2.83.45.2-2.3-2.0-1.9-1.8-1.9-1.9-1.8-1.7-1.4-1.4-1.9
Liver weight, left5.38.713.5-3.7-3.0-2.8-3.2-2.9-3.0-2.8-2.7-2.7-2.9-2.6
Liver weight, right0.20.42.90.40.20.10.10.40.50.50.70.2-0.51.7
Locomotor activity0.40.61.4-1.2-1.0-0.5-0.8-0.8-1.0-1.0-0.3-0.1-0.6-0.9
Locomotor testing distance0.81.42.3-1.4-1.4-0.9-1.2-1.1-1.5-1.5-0.8-0.5-1.1-1.4
Locomotor testing rearing0.61.33.1-1.4-1.1-0.5-0.9-0.7-1.3-1.7-0.6-0.2-1.1-1.8
Locomotion in novel chamber0.10.10.4-0.6-0.20.2-0.1-0.0-0.20.20.60.4-0.30.4
Locomotion in novel chamber post-restriction1.01.63.7-1.1-1.4-1.2-1.1-1.9-1.5-0.7-1.4-1.5-0.7-0.6
Fecal boli incidents, locomotor time 10.00.10.30.60.20.00.1-0.0-0.10.20.10.10.5-0.3
Change in fecal boli incidents, locomotor task0.10.10.50.10.10.30.60.40.70.40.10.10.20.4
Time >=10cm from walls, locomotor time 13.03.23.81.61.81.91.71.71.61.91.91.91.91.6
Bouts of movement, locomotor time 10.30.30.50.70.70.50.70.70.60.40.10.10.20.7
Total resting periods, locomotor time 10.30.30.60.70.70.50.70.70.60.40.20.10.20.8
Rest time, locomotor task time 10.00.10.30.60.30.10.00.1-0.00.00.10.0-0.10.4
Distance moved, locomotor task time 10.20.41.1-1.1-0.6-0.6-0.4-0.4-0.3-0.5-0.6-0.6-0.6-0.6
Vertical activity count, locomotor time 10.20.40.8-0.9-0.7-0.8-0.7-0.6-0.4-0.5-0.5-0.6-0.7-0.5
Time >=10cm from walls, locomotor time 20.10.10.50.10.20.1-0.10.2-0.30.10.70.6-0.20.5
Bouts of movement, locomotor time 20.20.41.21.10.80.40.50.60.90.60.20.10.50.6
Total resting periods, locomotor time 20.40.71.81.31.00.70.80.81.10.80.40.30.70.8
Rest time, locomotor task time 23.54.58.02.82.42.22.21.92.02.31.41.32.31.9
Distance moved, locomotor task time 20.91.02.3-1.5-0.9-1.0-1.1-0.6-0.8-1.2-0.6-0.6-1.5-0.7
Vertical activity count, locomotor time 22.94.05.8-2.1-2.0-2.2-2.3-1.6-2.0-2.4-1.4-1.5-2.4-1.7
Light reinforcement 10.20.41.40.3-0.4-0.8-0.3-0.7-0.2-0.5-1.2-1.1-0.2-0.1
Light reinforcement 20.50.71.7-0.2-0.8-1.0-0.6-1.1-0.6-0.7-1.2-1.3-0.8-0.2
Bone: marrow area15.634.138.4-6.2-6.1-5.6-6.0-6.0-6.1-6.0-5.6-5.3-5.4-5.9
Bone: maximum diameter5.911.014.6-3.2-3.5-3.7-3.7-3.8-3.3-2.8-3.2-3.4-3.1-2.4
Bone: maximum force1.62.94.4-1.6-2.0-2.1-1.8-2.1-1.4-1.1-1.5-1.9-1.8-0.3
Bone: maximum moment1.83.25.0-1.7-2.1-2.2-2.0-2.1-1.5-1.3-1.6-2.0-2.0-0.3
Mean time between licks in bursts0.00.00.1-0.1-0.3-0.10.2-0.2-0.00.3-0.2-0.10.3-0.1
Mean num. licks in bursts0.20.30.8-0.9-0.7-0.10.1-0.2-0.3-0.6-0.7-0.7-0.6-0.5
Cd content in liver5.25.78.92.12.43.03.02.62.32.22.12.42.51.2
Co content in liver1.92.23.01.21.61.71.71.61.51.51.51.71.70.5
Cu content in liver0.60.71.2-0.4-0.7-1.1-1.0-0.8-0.7-0.9-0.9-0.9-0.8-0.6
Fe content in liver0.00.10.2-0.20.00.1-0.30.0-0.2-0.30.30.3-0.1-0.4
K content in liver0.40.30.8-0.6-0.4-0.8-0.9-0.7-0.2-0.5-0.5-0.3-0.2-0.7
Mg content in liver0.40.41.10.70.90.50.50.61.00.50.50.70.70.2
Mn content in liver0.10.10.20.20.2-0.4-0.4-0.20.0-0.00.20.0-0.20.3
Na content in liver0.60.61.4-0.7-0.5-0.8-1.0-0.8-0.7-0.8-0.7-0.6-0.4-1.2
Rb content in liver3.44.05.32.02.31.91.72.02.22.02.22.11.81.9
Se content in liver1.31.52.81.21.21.31.41.01.21.50.91.01.70.9
Sr content in liver1.00.81.2-0.8-1.0-1.0-0.9-1.0-1.0-0.7-1.0-1.1-0.9-0.5
Zn content in liver0.30.40.70.70.50.60.60.30.40.80.60.50.60.8
Bone: minimum diameter14.726.730.4-5.4-5.5-5.3-5.2-5.5-5.2-4.8-5.2-5.2-4.7-4.7
Time in familiar zone, hab. session 10.20.21.4-0.5-0.30.0-0.0-0.3-0.1-0.4-0.5-0.10.2-1.2
Time in novel zone, hab. session 10.50.52.01.00.80.30.40.60.20.70.80.30.11.4
Total zone transitions, hab. session 10.10.10.4-0.6-0.3-0.4-0.30.1-0.0-0.10.00.2-0.1-0.1
Total locomotion distance, hab. session 11.01.42.7-1.5-1.3-1.4-1.3-0.9-1.1-1.2-0.8-1.0-1.6-0.3
Locomotion velocity, hab. session 11.31.83.2-1.8-1.6-1.6-1.4-1.1-1.2-1.3-1.0-1.1-1.7-0.6
Time in familiar zone, hab. session 20.50.53.0-1.1-0.6-0.1-0.3-0.4-0.6-0.8-0.5-0.1-0.0-1.7
Time in novel zone, hab. session 20.50.63.71.10.40.00.30.10.40.70.5-0.1-0.21.9
Total zone transitions, hab. session 20.10.10.4-0.50.10.00.00.30.3-0.00.30.60.3-0.3
Total locomotion distance, hab. session 20.20.20.7-0.8-0.5-0.5-0.3-0.3-0.2-0.7-0.4-0.2-0.5-0.5
Locomotion velocity, hab. session 20.10.20.7-0.8-0.5-0.4-0.2-0.2-0.1-0.5-0.3-0.1-0.4-0.4
Novel to familiar place preference ratio0.50.51.1-0.4-0.7-0.8-0.7-0.8-0.7-0.4-0.9-1.1-0.6-0.2
Novelty place preference0.20.30.6-0.2-0.5-0.6-0.5-0.6-0.5-0.2-0.6-0.8-0.5-0.1
Time in novel zone, NPP test0.20.20.5-0.2-0.4-0.5-0.5-0.5-0.6-0.2-0.5-0.7-0.50.0
Total zone transitions, NPP test0.00.10.2-0.5-0.1-0.3-0.20.10.30.00.20.40.00.2
Total locomotion distance, NPP test0.60.81.9-1.4-1.1-1.0-0.9-0.8-0.7-1.0-0.6-0.6-1.2-0.3
Locomotion velocity, NPP test0.20.30.8-0.9-0.8-0.8-0.5-0.5-0.3-0.6-0.5-0.4-0.7-0.2
Intraocular pressure0.30.40.80.0-0.9-0.9-0.5-0.7-0.8-0.5-0.9-0.9-0.4-0.5
Delta distance traveled before/after self-admin0.20.20.7-0.10.40.80.70.50.40.1-0.10.00.4-0.3
Delta ambulatory time before/after self-admin0.10.10.3-0.40.00.40.40.10.2-0.2-0.3-0.20.1-0.6
Parametrial fat weight0.51.21.9-1.0-1.2-1.3-1.1-1.2-1.1-0.7-1.0-1.4-1.40.1
Pavlov. Cond. lever latency3.13.96.32.31.82.42.51.61.82.01.61.72.31.6
Pavlov. Cond. magazine entry latency5.77.49.5-2.8-2.5-3.0-3.1-2.5-2.6-2.8-2.6-2.7-2.9-2.4
Pavlov. Cond. change in total contacts5.15.48.5-2.2-2.0-2.8-2.9-1.9-2.2-2.5-2.1-2.2-2.6-2.1
Pavlov. Cond. index score5.06.49.0-2.7-2.3-2.9-3.0-2.2-2.3-2.5-2.3-2.4-2.7-2.3
Pavlov. Cond. latency score4.15.17.4-2.5-2.1-2.6-2.7-2.0-2.1-2.3-2.1-2.1-2.3-2.1
Pavlov. Cond. lever contacts3.94.77.1-2.5-1.9-2.5-2.7-1.7-2.0-2.3-1.8-1.9-2.5-1.8
Pavlov. Cond. magazine entry number4.45.57.32.32.12.62.72.12.22.52.22.32.52.2
Pavlov. Cond. intertrial magazine entries0.30.41.1-0.2-0.8-0.4-0.1-0.8-0.4-0.5-0.9-0.60.2-1.0
Pavlov. Cond. lever-magazine prob. diff.5.36.69.6-2.6-2.4-3.0-3.1-2.3-2.4-2.5-2.4-2.5-2.7-2.2
Pavlov. Cond. response bias7.99.813.6-3.2-2.9-3.6-3.7-2.8-3.0-3.2-2.8-3.1-3.6-2.3
Pavlov. Cond. lever latency0.50.70.90.90.90.80.90.90.80.80.70.70.70.8
Pavlov. Cond. magazine entry latency2.83.34.21.71.81.71.51.71.92.02.02.02.01.5
Pavlov. Cond. change in total contacts0.30.51.8-0.8-0.7-0.5-0.7-0.7-0.7-0.8-0.6-0.3-0.2-1.4
Pavlov. Cond. index score0.00.00.1-0.2-0.0-0.0-0.3-0.1-0.10.00.20.20.2-0.2
Pavlov. Cond. latency score0.00.00.2-0.00.10.0-0.20.0-0.00.20.40.40.20.0
Pavlov. Cond. lever contacts0.30.40.5-0.7-0.7-0.6-0.7-0.7-0.6-0.7-0.6-0.5-0.5-0.7
Pavlov. Cond. magazine entry number3.44.25.7-1.8-2.0-2.1-1.8-1.9-1.9-2.1-2.4-2.3-2.0-1.9
Pavlov. Cond. intertrial magazine entries12.619.023.5-4.0-4.5-4.6-4.2-4.3-4.1-4.4-4.8-4.7-4.1-4.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.00.10.1-0.10.00.10.20.30.40.3-0.0
Pavlov. Cond. response bias0.00.00.1-0.3-0.20.0-0.1-0.2-0.1-0.10.00.10.1-0.3
Time in closed arm before self-admin0.00.00.1-0.30.10.1-0.10.1-0.3-0.2-0.3-0.3-0.30.1
Time in closed arm after self-admin0.50.51.10.10.71.10.80.90.60.70.60.50.40.7
Time in open arm before self-admin0.91.01.81.00.81.00.90.70.81.21.31.00.71.3
Time in open arm after self-admin0.00.10.30.2-0.0-0.10.0-0.20.00.10.10.20.6-0.2
Bone: periosteal estimation11.524.327.6-5.0-5.2-5.2-5.2-5.3-5.0-4.7-4.7-4.9-4.8-4.1
Bone: periosteal perimeter6.511.114.4-3.5-3.6-3.6-3.7-3.8-3.4-2.7-3.2-3.4-3.1-2.5
Bone: post-yield work1.52.23.0-1.7-1.6-1.5-1.6-1.5-1.5-1.3-1.4-1.4-1.4-1.2
Progressive ratio test 1 active lever presses3.03.74.4-2.0-2.1-2.1-2.0-2.1-2.1-1.8-1.9-1.8-1.7-1.6
Progressive ratio test 1 breakpoint3.54.35.1-2.1-2.2-2.3-2.1-2.2-2.1-2.0-2.1-2.0-1.9-1.7
Progressive ratio test 1 inactive lever presses3.34.85.7-2.2-2.4-2.4-2.3-2.3-2.4-2.2-2.0-1.9-1.9-2.0
Progressive ratio test 2 active lever presses5.86.88.5-2.6-2.9-2.8-2.6-2.9-2.6-2.4-2.6-2.5-2.2-2.3
Progressive ratio test 2 breakpoint6.37.29.0-2.7-3.0-2.9-2.7-3.0-2.7-2.5-2.7-2.6-2.3-2.4
Progressive ratio test 2 inactive lever presses2.33.74.5-2.0-2.1-2.1-1.7-2.1-1.9-1.8-2.0-1.9-1.7-1.6
Incentive Sensitization - Responses2.83.95.2-2.0-2.3-2.1-2.0-2.3-1.9-1.7-2.0-1.9-1.5-2.0
Incentive Sensitization - Breakpoint2.93.85.1-2.1-2.3-2.0-1.9-2.3-1.9-1.7-2.0-1.8-1.5-2.0
Sum of active levers in priming session hrs 5-61.11.02.21.51.20.80.71.00.80.80.91.11.40.3
Progressive ratio0.10.10.4-0.2-0.1-0.2-0.2-0.40.00.2-0.7-0.60.3-0.3
Food seeking constrained by brief footshock2.73.36.2-2.5-1.6-1.3-1.6-1.6-2.0-2.0-1.7-1.2-1.3-2.5
Seeking ratio, punishment vs. effort1.11.62.8-1.5-1.3-1.0-1.1-1.0-1.6-1.7-0.7-0.6-1.4-1.6
Retroperitoneal fat weight0.52.22.7-1.7-1.6-1.6-1.4-1.3-1.2-1.5-1.7-1.6-1.6-0.8
Reaction time number correct0.30.61.80.80.60.60.80.30.71.20.60.40.91.3
Reaction time mean minus median0.10.30.50.70.70.60.60.60.50.40.60.50.20.5
Reaction time mean minus median AUC0.61.62.11.51.41.31.31.11.11.31.41.21.11.3
Reaction time num false alarms3.65.06.7-2.6-2.3-2.4-2.4-2.5-2.2-2.0-2.3-2.1-1.8-2.0
Reaction time num false alarms AUC3.85.97.7-2.8-2.5-2.5-2.5-2.7-2.4-2.2-2.5-2.4-2.1-2.1
Reaction time trials correct on left0.30.61.80.80.60.60.80.30.71.20.60.40.91.3
Reaction time trials on left0.30.61.80.70.50.60.80.30.61.20.50.30.81.4
Reaction time mean0.60.91.71.21.20.90.81.00.70.61.31.10.50.9
Reaction time mean AUC0.91.42.41.51.51.20.91.20.80.81.61.40.71.0
Median of all reaction times0.60.91.71.21.20.90.71.00.60.61.31.10.51.0
Reaction time omissions0.30.51.4-0.2-0.7-0.6-0.5-0.8-0.7-0.7-0.5-0.9-1.20.2
Reaction time false alarm rate4.15.77.3-2.7-2.3-2.4-2.6-2.3-2.3-2.4-2.3-2.1-2.2-2.4
Reaction time premature initiation rate0.81.12.2-0.7-1.2-0.9-0.7-1.2-1.1-1.0-1.5-1.5-1.0-0.7
Reaction time premature initiations0.30.51.3-0.3-0.9-0.5-0.2-1.0-0.7-0.4-1.1-1.2-0.4-0.1
Std. dev. reaction times0.20.40.70.80.80.60.60.70.60.40.80.70.20.6
Reaction time trials completed0.30.61.80.70.50.60.80.30.61.20.50.30.81.4
Reaction time trials AUC0.30.61.80.70.60.60.80.40.81.20.60.40.91.3
Run reversals in cocaine runway, females0.20.20.80.50.3-0.20.20.40.30.30.50.3-0.20.9
Run reversals in cocaine runway, males0.10.10.20.40.10.10.10.00.20.40.2-0.00.10.4
Latency to leave start box in cocaine runway0.20.30.40.70.50.50.50.40.50.50.60.50.30.6
Latency to leave start box in cocaine runway, F0.40.41.00.90.70.50.40.50.40.70.80.50.31.0
Latency to leave start box in cocaine runway, M0.00.00.2-0.1-0.10.20.20.00.2-0.3-0.00.20.1-0.4
Std. dev. time between licks in bursts0.10.10.20.30.20.10.30.40.50.20.20.30.3-0.1
Total sessions with >9 infusions0.10.10.2-0.5-0.4-0.4-0.3-0.3-0.4-0.2-0.2-0.1-0.1-0.2
Short access day 1 total inactive lever presses2.73.54.7-1.9-2.1-1.9-1.8-1.9-2.1-1.8-1.7-1.8-2.2-1.1
Short access day 10 total inactive lever presses0.10.20.40.2-0.4-0.6-0.3-0.3-0.2-0.4-0.4-0.5-0.5-0.1
Short access day 1 total infusions0.30.40.7-0.5-0.6-0.8-0.7-0.8-0.8-0.5-0.5-0.5-0.4-0.4
Short access day 10 total infusions2.63.44.4-2.1-1.9-2.1-2.0-1.9-2.0-1.9-1.6-1.4-1.6-1.8
Short access total infusions1.51.92.5-1.4-1.3-1.6-1.5-1.5-1.6-1.4-1.2-1.1-1.2-1.2
Short access day 1 locomotion1.62.02.9-1.2-1.6-1.7-1.4-1.5-1.5-1.3-1.3-1.4-1.3-1.2
Short access day 10 total locomotion4.48.210.9-3.3-2.8-2.6-2.6-2.6-3.0-3.1-2.9-2.7-2.8-3.0
Short access total locomotion3.03.74.6-2.1-2.0-2.0-1.8-1.8-2.0-1.9-1.8-1.8-1.9-1.8
One hour access (0.3 mA shock)1.11.32.1-1.1-1.1-1.4-1.4-1.2-1.2-1.0-0.9-0.8-0.7-1.3
Compulsive drug intake0.50.61.40.90.70.80.70.40.51.00.70.40.61.2
One hour access (shock baseline)1.01.62.8-1.5-1.3-1.5-1.4-1.1-1.1-1.3-1.0-0.7-0.8-1.7
Social response proportion0.30.40.70.40.60.40.40.70.80.80.50.60.80.5
Social responses0.00.00.2-0.2-0.2-0.1-0.10.00.0-0.10.00.20.1-0.4
Social time0.00.10.3-0.1-0.2-0.2-0.3-0.2-0.5-0.00.0-0.1-0.1-0.1
Soleus weight0.10.40.8-0.7-0.7-0.8-0.8-0.9-0.3-0.3-0.6-0.7-0.5-0.5
Bone: stiffness0.30.51.1-1.0-1.0-1.0-0.9-1.0-0.4-0.4-0.6-0.5-0.4-0.4
Tibialis anterior weight0.10.30.90.20.3-0.10.30.40.90.2-0.50.00.7-0.9
Time to tail flick, vehicle, before self-admin0.20.20.60.2-0.2-0.0-0.1-0.5-0.30.30.70.5-0.30.7
Time to tail flick, vehicle, after self-admin0.10.10.50.2-0.4-0.3-0.1-0.7-0.30.2-0.3-0.40.10.3
Time to tail flick, test, before self-admin0.20.20.40.10.60.60.30.70.20.10.50.60.2-0.1
Time to tail flick, test, after self-admin0.00.00.1-0.00.0-0.2-0.2-0.2-0.3-0.1-0.2-0.2-0.1-0.0
Delta time to tail flick, vehicle, before/after SA1.21.22.6-0.9-0.9-1.1-0.9-0.9-1.0-1.1-1.6-1.5-0.7-1.0
Delta time to tail flick, test, before/after SA0.00.00.2-0.0-0.1-0.3-0.2-0.4-0.00.1-0.2-0.10.20.1
Tibia length0.10.20.9-0.7-0.6-0.3-0.2-0.50.10.3-0.0-0.3-0.40.9
Ambulatory time before self-admin0.10.10.40.50.1-0.1-0.3-0.1-0.00.50.2-0.00.20.6
Ambulatory time after self-admin0.00.00.10.00.00.1-0.1-0.2-0.10.0-0.3-0.40.0-0.1
Bone: tissue strength1.61.62.21.01.11.11.11.21.51.41.51.31.21.5
Total heroin consumption0.70.81.9-0.9-0.8-0.7-1.2-0.9-1.4-1.0-0.5-0.5-0.9-0.9
Bone: trabecular number3.35.47.2-2.0-2.3-2.5-2.4-2.7-2.6-2.1-2.1-2.6-2.7-1.1
Bone: trabecular spacing1.31.83.20.91.31.51.31.61.51.11.21.71.80.1
Bone: trabecular thickness4.86.09.4-1.7-2.5-2.9-2.5-2.8-2.4-2.0-2.5-3.1-2.9-0.7
Bone: trabecular tissue density0.81.24.41.10.80.71.10.71.01.40.90.50.72.1
Water consumed over 24 hours0.10.20.7-0.8-0.4-0.4-0.3-0.3-0.1-0.4-0.4-0.5-0.60.0
Number of responses in last shaping day0.40.40.9-0.2-0.7-0.8-0.8-0.7-1.0-0.6-0.1-0.4-1.0-0.0