Hub : Genes

Tacc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	alternative polyA	XM_006251329.4	0.32	0.16	1.8e-03	0.08	0.05	0.01	0.05	2.2e-02	5.7e-02	2.0e-01	6.0e-02
2	Liver	mRNA stability	Tacc3	0.08	0.05	3.1e-07	0.07	0.06	0.06	0.07	4.6e-08	3.9e-07	5.4e-07	6.0e-08
3	Adipose	gene expression	Tacc3	0.03	0.02	3.6e-03	0.02	0.01	0.01	0.01	2.1e-03	2.2e-02	9.4e-03	8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.2	2.0	3.9	2.0	0.9	-1.1
Area under the delay curve	1.5	1.8	4.7	-0.4	0.7	-2.2
BMI with tail	1.2	4.0	10.0	-3.2	-1.3	0.5
BMI without tail	1.1	3.4	7.0	-2.7	-1.5	1.1
Body weight	3.4	14.7	28.1	-5.3	-3.3	2.3
Weight adjusted by age	0.7	1.1	2.8	-1.7	-0.7	-0.0
Bone surface	0.3	0.5	0.8	0.9	0.1	-0.8
Bone volume	0.5	0.9	2.0	1.4	0.3	-0.8
Breakpoint value in progressive ratio session	0.1	0.2	0.5	-0.2	-0.0	0.7
Number of licking bursts	1.6	2.6	3.9	-1.3	-1.5	2.0
Context. condit. distance diff. score	0.1	0.1	0.2	-0.3	0.5	-0.1
Locomotion velocity, session 1	0.2	0.2	0.4	0.6	0.4	-0.3
Locomotion distance, session 1	0.4	0.6	1.0	1.0	0.7	-0.4
Locomotion velocity, session 2	1.2	1.4	2.5	1.6	1.2	0.5
Locomotion distance, session 2	2.3	3.2	4.5	1.8	2.1	-1.3
Locomotion velocity, session 3	0.3	0.4	0.8	0.2	0.9	-0.5
Locomotion distance, session 3	0.1	0.1	0.2	-0.3	0.4	-0.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.2	-0.2	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.1	0.0	-0.0
Locomotion velocity, session 7	1.8	2.0	3.0	-1.5	-0.8	1.7
Locomotion distance, session 7	0.3	0.4	0.7	-0.3	0.9	0.6
Stereotopy head waving bouts, day 7	0.8	0.9	2.1	-1.5	-0.6	0.6
Stereotopy head waving duration, day 7	1.6	1.9	3.8	-1.9	-0.9	1.0
Locomotion velocity, session 8	0.3	0.4	0.7	0.8	0.6	-0.3
Locomotion distance, session 8	0.7	1.0	1.7	0.9	1.3	-0.7
Degree of sensitization distance	0.4	0.4	0.8	0.6	0.2	0.9
Degree of sensitization stereotypy	1.0	1.1	2.2	-1.5	-0.7	0.8
Conditioned locomotion	0.9	1.0	1.6	-0.1	1.2	-1.3
Cocaine response after cond. corrected	0.9	1.1	1.8	0.8	1.4	-0.9
Cocaine response after cond. not corrected	0.3	0.4	0.8	0.4	0.9	-0.5
Cocaine response before conditioning	0.9	1.0	1.4	-0.7	-1.2	1.1
Saline control response	0.1	0.1	0.4	0.6	0.1	-0.1
Bone: connectivity density	1.0	1.5	2.1	1.4	1.0	-1.2
Bone: cortical apparent density	0.2	0.3	0.8	0.3	-0.2	-0.9
Bone: cortical area	3.1	4.8	6.7	-2.6	-2.3	1.5
Bone: cortical porosity	0.2	0.2	0.3	-0.5	0.5	0.3
Bone: cortical porosity	0.4	0.5	1.0	-1.0	0.3	0.5
Bone: cortical thickness	2.0	3.4	6.5	-2.5	-1.7	0.9
Bone: cortical thickness	0.7	0.8	1.4	-0.4	0.9	-1.2
Bone: cortical tissue density	0.2	0.3	0.9	0.4	-0.1	-0.9
Condit. Reinf. active minus inactive responses	0.7	0.8	1.3	0.9	1.1	-0.6
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.0	1.4	1.4	-1.0
Condit. Reinf. active responses	0.3	0.3	0.5	0.6	0.7	-0.4
Condit. Reinf. inactive responses	0.6	0.7	1.2	-0.8	-1.1	0.7
Incentive salience index mean	0.1	0.2	0.3	0.5	0.4	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.2	-0.4	-0.2
Condit. Reinf. active minus inactive responses	0.8	1.1	1.6	-0.7	-1.1	1.3
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	0.3	0.7	-0.7
Condit. Reinf. active responses	0.1	0.2	0.4	0.1	-0.4	0.6
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.3	-0.4	0.6
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.8	-0.5	0.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.2	-0.2	0.4
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.4	0.1	-0.3
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.5	-0.6	0.1
Conditioned locomotion	0.9	1.1	1.8	-1.3	-0.5	1.2
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.2	-0.6	0.4
Patch foraging indifference point AUC	0.1	0.1	0.2	0.4	-0.2	0.4
Delay disc. indifference point, 0s delay	4.4	4.8	10.0	-1.1	1.7	-3.2
Delay disc. indifference point, 16s delay	1.0	1.1	2.6	0.6	0.7	-1.6
Delay disc. indifference point, 2s delay	1.8	2.0	3.9	-0.6	1.3	-2.0
Delay disc. indifference point, 24s delay	1.8	2.0	4.9	-0.0	1.0	-2.2
Delay disc. indifference point, 4s delay	1.5	1.6	3.7	0.5	0.9	-1.9
Delay disc. indifference point, 8s delay	0.4	0.4	0.8	-0.4	-0.6	-0.9
Indifference point function ln k	0.1	0.2	0.5	0.7	0.0	-0.0
Indifference point function log k	0.1	0.2	0.5	0.7	0.0	-0.0
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	-0.3	-0.8	0.6
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	-0.8	-0.6	0.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.4	-0.3	-0.5	0.7
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	-0.5	0.1	-0.1
Patch foraging total patch changes 6 sec	0.7	1.1	1.7	-0.4	-1.3	1.1
Patch foraging time to switch 0 sec	0.4	0.8	1.9	-1.4	0.3	-0.6
Patch foraging water rate 0 sec	1.5	3.1	4.6	-0.3	-2.1	2.1
Patch foraging water rate 12 sec	0.3	0.6	1.0	0.2	-0.9	1.0
Patch foraging water rate 18 sec	0.8	1.3	2.0	-0.2	-1.3	1.4
Patch foraging water rate 24 sec	2.8	4.0	5.8	-0.5	-2.4	2.4
Patch foraging water rate 6 sec	2.9	4.2	5.9	-1.1	-2.3	2.4
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	5.2	2.3	0.2	0.7
Distance traveled before self-admin	0.5	0.7	1.5	0.3	1.2	-0.7
Distance traveled after self-admin	0.4	0.5	1.5	0.2	1.2	-0.2
Extensor digitorum longus weight	2.3	8.9	10.3	-3.2	-3.2	2.5
Bone: elastic displacement	0.5	0.6	0.9	-0.8	-0.9	0.6
Bone: elastic work	3.7	4.8	5.6	-2.2	-2.4	2.0
Bone: endosteal estimation	1.1	2.3	2.9	-1.3	-1.5	1.7
Bone: endosteal perimeter	0.7	1.4	2.1	-0.8	-1.4	1.3
Epididymis fat weight	1.1	3.7	8.4	-2.9	-1.2	1.0
Delta time in closed arm before/after self-admin	0.9	0.9	1.2	0.6	1.0	-1.1
Delta time in open arm before/after self-admin	0.8	0.7	1.9	-1.4	-0.6	-0.1
Diff in mean of infusions in LGA sessions	2.6	3.2	4.5	1.3	1.8	-2.1
Delay discount exponential model param	1.5	1.7	4.5	0.3	-0.7	2.1
Extinction: sum of active levers before priming	0.0	0.1	0.1	-0.3	-0.2	-0.2
Active lever presses in extinction session 6	0.5	0.5	0.9	-0.4	0.9	-0.6
Bone: final force	3.8	6.0	8.6	-2.9	-2.2	2.2
Bone: final moment	4.1	6.6	8.5	-2.9	-2.3	2.5
Food consumed during 24 hour testing period	0.4	0.5	1.1	-0.1	-1.1	0.7
Glucose	0.4	0.6	1.1	0.1	-0.8	1.1
Heart weight	0.8	1.3	1.6	-1.3	-1.1	1.0
Delay discount hyperbolic model param	1.7	1.9	5.0	0.2	-0.8	2.2
Intermittent access intake day 1-15 change	1.2	2.5	3.8	1.8	2.0	-0.7
Intermittent access intake escalation	0.8	1.5	2.4	1.4	1.6	-0.4
Intermittent access intake escalation 2	0.9	1.1	1.9	1.4	1.0	0.4
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.6	1.3	0.3	-0.9
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.6	0.8	0.4	-0.5
Intermitt. access escalation Index	0.2	0.3	0.7	0.4	0.8	-0.4
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.4	0.1	-0.6
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	0.4	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	0.3	-0.1
Intermittent access total infusions	0.0	0.0	0.1	0.3	-0.1	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.6	-0.2	0.0
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.4	0.4	-0.3
Intermittent access total locomotion	0.0	0.0	0.1	0.1	0.3	0.1
Intermittent access standard deviation	0.1	0.2	0.4	0.5	0.6	-0.1
Left kidney weight	3.5	16.4	23.3	-4.8	-3.8	3.4
Right kidney weight	2.2	10.0	18.9	-4.3	-2.6	2.1
Cocaine induced anxiety	0.1	0.1	0.2	0.3	0.3	0.4
Post-drug Anxiety	0.4	0.4	1.0	0.1	1.0	-0.4
Baseline Anxiety	0.5	0.5	1.0	-1.0	0.4	-0.6
Tail length	1.2	4.7	5.8	-1.7	-2.3	2.4
Length with tail	3.2	14.0	14.6	-3.8	-3.8	3.6
Length without tail	2.0	6.4	9.2	-3.0	-2.4	2.0
Times rat made contact with spout	0.4	0.4	1.2	1.1	-0.2	0.3
Lifetime Intake	0.1	0.1	0.1	0.4	-0.2	0.0
Liver weight, left	0.3	0.4	0.8	-0.9	-0.4	0.6
Liver weight, right	2.2	3.8	5.7	-2.4	-1.8	1.5
Locomotor activity	1.4	2.1	3.5	-0.2	-1.7	1.9
Locomotor testing distance	0.9	1.6	2.0	-1.1	-1.4	1.3
Locomotor testing rearing	1.8	3.7	4.5	-1.6	-2.1	2.0
Locomotion in novel chamber	0.5	0.7	1.1	-0.4	1.0	-0.9
Locomotion in novel chamber post-restriction	0.8	1.3	2.3	0.1	1.2	-1.5
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.2	0.1	0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.4	0.1	0.2
Time >=10cm from walls, locomotor time 1	1.3	1.4	3.0	-1.7	0.2	-1.0
Bouts of movement, locomotor time 1	0.6	0.7	1.6	-0.3	0.5	-1.3
Total resting periods, locomotor time 1	0.5	0.6	0.9	-0.7	0.6	-1.0
Rest time, locomotor task time 1	1.8	2.3	3.2	-1.8	-1.4	1.2
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.7	0.1	-0.7
Vertical activity count, locomotor time 1	0.5	1.3	2.5	1.6	0.7	-0.9
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.7	-0.8	-0.5	0.9
Bouts of movement, locomotor time 2	0.2	0.4	0.5	0.4	0.7	-0.7
Total resting periods, locomotor time 2	0.2	0.3	0.6	0.2	0.4	-0.8
Rest time, locomotor task time 2	0.6	0.8	1.8	-0.8	-1.3	0.0
Distance moved, locomotor task time 2	0.3	0.4	0.7	0.6	0.9	-0.2
Vertical activity count, locomotor time 2	0.8	1.0	1.9	1.0	1.4	-0.4
Light reinforcement 1	1.3	3.2	4.8	-2.2	-1.7	1.4
Light reinforcement 2	2.2	3.3	3.8	-2.0	-1.8	1.7
Bone: marrow area	0.9	1.9	2.3	-1.3	-1.3	1.5
Bone: maximum diameter	3.0	5.6	7.6	-2.2	-2.8	2.1
Bone: maximum force	2.5	4.4	4.8	-2.2	-2.2	1.9
Bone: maximum moment	2.9	5.1	5.3	-2.2	-2.3	2.3
Mean time between licks in bursts	0.3	0.8	1.4	1.2	-0.3	1.0
Mean num. licks in bursts	2.0	3.1	4.2	2.1	1.4	-1.7
Cd content in liver	0.0	0.0	0.0	0.2	0.0	-0.2
Co content in liver	0.4	0.4	1.2	-1.1	0.0	0.3
Cu content in liver	2.0	2.3	5.1	0.7	1.2	-2.3
Fe content in liver	3.9	4.7	7.8	0.7	2.4	-2.8
K content in liver	0.8	0.8	1.4	0.4	0.9	-1.2
Mg content in liver	0.5	0.5	1.3	-1.1	-0.4	0.3
Mn content in liver	0.3	0.4	1.1	1.1	0.1	-0.0
Na content in liver	0.7	0.8	2.1	0.1	1.4	-0.5
Rb content in liver	0.2	0.2	0.6	-0.8	-0.0	-0.2
Se content in liver	0.2	0.2	0.4	0.4	0.1	-0.7
Sr content in liver	2.6	2.2	2.8	-1.2	-1.7	1.5
Zn content in liver	0.9	1.0	1.7	-0.2	-1.3	1.1
Bone: minimum diameter	1.0	1.8	2.4	-1.1	-1.5	1.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.2	0.6	0.3
Time in novel zone, hab. session 1	0.3	0.3	0.9	-0.1	-0.9	0.2
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.6	0.2	0.2
Total locomotion distance, hab. session 1	0.6	0.9	2.2	1.5	0.6	-0.1
Locomotion velocity, hab. session 1	0.5	0.6	1.5	1.2	0.6	-0.2
Time in familiar zone, hab. session 2	3.0	3.1	3.9	1.7	2.0	-1.6
Time in novel zone, hab. session 2	6.3	6.4	8.5	-2.3	-2.9	2.3
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.1	-0.6	0.1
Total locomotion distance, hab. session 2	0.2	0.2	0.6	0.2	-0.8	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.2	-0.5	0.1
Novel to familiar place preference ratio	0.5	0.5	0.7	0.8	0.7	-0.6
Novelty place preference	0.3	0.3	0.5	0.7	0.4	-0.4
Time in novel zone, NPP test	0.2	0.2	0.4	0.7	0.1	-0.1
Total zone transitions, NPP test	0.1	0.2	0.2	0.5	0.5	-0.2
Total locomotion distance, NPP test	0.7	1.0	1.0	1.0	1.0	-1.0
Locomotion velocity, NPP test	1.1	1.6	1.9	1.1	1.4	-1.3
Intraocular pressure	0.3	0.4	0.7	-0.3	-0.9	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.1	0.4	-0.2
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	0.7	0.9	-0.4
Parametrial fat weight	0.2	0.5	0.9	0.3	1.0	-0.7
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.0	0.5	0.3
Pavlov. Cond. magazine entry latency	0.9	1.1	2.6	1.6	0.3	-0.7
Pavlov. Cond. change in total contacts	0.8	0.8	1.2	1.1	0.4	-1.0
Pavlov. Cond. index score	0.9	1.1	1.9	1.4	0.4	-1.2
Pavlov. Cond. latency score	0.7	0.8	1.5	1.2	0.2	-1.0
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.1	-0.2	-0.4
Pavlov. Cond. magazine entry number	1.2	1.5	3.1	-1.8	-0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.7	0.8	2.0	-1.4	-0.3	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	0.9	1.5	1.2	0.3	-1.1
Pavlov. Cond. response bias	0.5	0.6	1.2	1.1	0.4	-0.7
Pavlov. Cond. lever latency	0.3	0.4	1.2	-1.1	-0.2	0.2
Pavlov. Cond. magazine entry latency	1.0	1.2	2.1	-1.4	-0.9	0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.1	-0.0
Pavlov. Cond. index score	0.0	0.0	0.1	0.2	-0.2	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	-0.2	0.1
Pavlov. Cond. lever contacts	0.7	1.0	2.1	1.4	0.6	-0.7
Pavlov. Cond. magazine entry number	1.6	2.0	2.1	1.4	1.4	-1.3
Pavlov. Cond. intertrial magazine entries	0.5	0.8	1.5	1.2	0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.1	-0.3	0.2
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	0.0	-0.1
Time in closed arm before self-admin	0.2	0.2	0.6	0.2	-0.7	0.4
Time in closed arm after self-admin	0.2	0.2	0.4	0.4	0.3	-0.6
Time in open arm before self-admin	0.5	0.5	0.9	-0.7	-0.6	0.9
Time in open arm after self-admin	0.9	1.0	1.7	-1.3	-0.8	0.8
Bone: periosteal estimation	2.2	4.7	5.4	-2.2	-2.3	1.9
Bone: periosteal perimeter	1.8	3.0	4.1	-2.0	-1.8	1.3
Bone: post-yield work	0.2	0.3	0.9	1.0	0.0	0.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.2	-0.0	-0.5	-0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	0.0	-0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.0	-0.3	0.1
Progressive ratio test 2 active lever presses	0.7	0.9	1.7	0.8	0.4	-1.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.6	0.7	0.4	-1.3
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.0	-0.1	-0.4
Incentive Sensitization - Responses	0.9	1.3	2.7	0.8	0.7	-1.6
Incentive Sensitization - Breakpoint	0.8	1.0	2.2	0.7	0.6	-1.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.4	0.8	-0.2
Progressive ratio	0.0	0.0	0.1	-0.3	-0.1	-0.2
Food seeking constrained by brief footshock	0.1	0.2	0.5	-0.2	-0.7	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	0.7	-0.3	-0.1
Retroperitoneal fat weight	0.2	0.8	2.2	-1.5	0.4	-0.3
Reaction time number correct	3.2	6.2	9.0	-0.9	-3.0	3.0
Reaction time mean minus median	0.4	0.9	1.3	1.2	0.9	-0.8
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.5	0.0	-0.2
Reaction time num false alarms	0.7	1.0	1.5	-1.2	0.7	-1.1
Reaction time num false alarms AUC	0.8	1.2	2.8	-1.7	0.4	-0.8
Reaction time trials correct on left	3.2	6.2	9.0	-0.9	-3.0	3.0
Reaction time trials on left	3.2	6.0	8.6	-0.8	-2.9	2.9
Reaction time mean	1.3	2.1	2.8	1.1	1.7	-1.5
Reaction time mean AUC	1.3	2.1	2.8	1.1	1.7	-1.6
Median of all reaction times	1.5	2.1	3.0	1.0	1.7	-1.6
Reaction time omissions	0.2	0.3	0.4	0.5	0.6	-0.4
Reaction time false alarm rate	1.9	2.7	4.2	-1.1	1.6	-2.0
Reaction time premature initiation rate	0.1	0.1	0.3	-0.6	0.2	0.2
Reaction time premature initiations	1.0	1.8	2.7	-1.0	-1.3	1.6
Std. dev. reaction times	0.5	1.0	1.3	0.7	1.1	-1.1
Reaction time trials completed	3.2	6.0	8.6	-0.8	-2.9	2.9
Reaction time trials AUC	3.1	5.9	8.5	-0.8	-2.9	2.9
Run reversals in cocaine runway, females	4.1	4.1	6.0	1.0	2.3	-2.5
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.1	-0.3	0.3
Latency to leave start box in cocaine runway	1.6	1.8	5.1	-2.3	-0.2	0.6
Latency to leave start box in cocaine runway, F	2.1	2.4	5.6	-2.4	-0.8	1.0
Latency to leave start box in cocaine runway, M	0.5	0.4	1.2	-1.1	0.3	-0.1
Std. dev. time between licks in bursts	0.3	0.4	0.9	0.6	-0.1	1.0
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	0.2	-0.2
Short access day 1 total inactive lever presses	0.5	0.7	1.5	-0.6	-0.3	1.2
Short access day 10 total inactive lever presses	0.3	0.8	1.7	0.6	-0.4	1.3
Short access day 1 total infusions	0.1	0.1	0.2	0.2	0.4	-0.4
Short access day 10 total infusions	0.4	0.5	0.9	1.0	-0.2	-0.6
Short access total infusions	0.2	0.3	0.7	0.8	0.0	-0.5
Short access day 1 locomotion	0.2	0.3	0.8	-0.0	-0.3	0.9
Short access day 10 total locomotion	0.4	0.7	1.3	1.2	0.7	-0.5
Short access total locomotion	0.2	0.3	0.6	0.8	0.4	0.2
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.2	-0.4	0.6
Compulsive drug intake	0.1	0.1	0.2	-0.4	0.4	0.1
One hour access (shock baseline)	0.0	0.0	0.0	0.1	-0.2	0.1
Social response proportion	0.5	0.6	1.5	1.2	-0.1	0.4
Social responses	1.2	1.6	2.7	-0.2	-1.4	1.6
Social time	1.0	1.4	2.6	1.6	1.0	-0.7
Soleus weight	4.1	11.9	14.5	-2.8	-3.8	3.6
Bone: stiffness	0.2	0.4	1.0	-1.0	-0.1	0.2
Tibialis anterior weight	1.2	4.1	4.7	-2.2	-2.1	1.8
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.3	0.2	1.1	-1.1
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.6	0.5	0.8	-1.3
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.3	-0.6	0.0
Time to tail flick, test, after self-admin	0.7	0.7	2.2	0.0	-1.5	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.1	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.3	0.4	0.5	0.7	-0.7	-0.2
Tibia length	0.5	1.4	3.0	-1.7	-0.8	0.7
Ambulatory time before self-admin	0.5	0.7	2.0	-0.1	1.4	-0.3
Ambulatory time after self-admin	1.5	1.8	4.2	0.7	2.1	-0.8
Bone: tissue strength	5.0	5.0	7.5	-1.3	-2.4	2.7
Total heroin consumption	1.6	1.9	3.6	-1.0	-1.1	1.9
Bone: trabecular number	0.5	0.8	1.5	1.2	0.5	-0.7
Bone: trabecular spacing	1.2	1.5	1.7	-1.2	-1.3	1.2
Bone: trabecular thickness	1.5	1.9	3.4	1.8	1.0	-1.2
Bone: trabecular tissue density	0.6	0.9	1.4	0.8	0.9	-1.2
Water consumed over 24 hours	0.6	0.8	1.1	1.1	-0.7	0.9
Number of responses in last shaping day	1.4	1.5	2.3	0.4	1.5	-1.4