Hub : Genes

Syt10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Syt10 0.1 0.05 4.3e-09 0.05 0.06 0.06 0.06 1.9e-08 1.4e-09 1.7e-09 1.2e-09
2 PL mRNA stability Syt10 0.07 0.04 6.5e-07 0.04 0.05 0.05 0.06 1.1e-05 5.5e-06 2.4e-06 1.0e-06
3 NAcc mRNA stability Syt10 0.04 0.02 5.0e-06 0.05 0.04 0.03 0.04 1.3e-07 2.5e-06 9.6e-06 4.4e-07
4 OFC gene expression Syt10 0.58 0.12 1.7e-11 0.39 0.37 0.36 0.36 3.5e-10 1.3e-09 1.5e-09 1.9e-09
5 PL gene expression Syt10 0.34 0.08 0.0e+00 0.44 0.5 0.5 0.5 7.0e-52 1.7e-62 3.0e-63 4.8e-63
6 IC gene expression Syt10 0.33 0.1 0.0e+00 0.33 0.41 0.38 0.36 1.1e-14 2.6e-18 6.4e-17 8.8e-16
7 IL gene expression Syt10 0.57 0.11 9.4e-16 0.34 0.49 0.43 0.47 7.4e-09 1.9e-13 1.6e-11 7.3e-13
8 IL mRNA stability Syt10 0.16 0.11 8.6e-03 0.11 0.02 0.01 0.06 1.1e-03 1.1e-01 1.5e-01 1.6e-02
9 Brain gene expression Syt10 0.33 0.09 0.0e+00 0.35 0.26 0.47 0.32 2.4e-33 4.0e-24 3.8e-48 7.4e-30
10 pVTA gene expression Syt10 0.08 0.05 2.5e-03 0.04 0.03 0.03 0.03 2.0e-04 1.6e-03 8.7e-04 1.0e-03
11 LHb gene expression Syt10 0.45 0.15 3.9e-04 0.13 0.11 0.18 0.02 5.6e-04 1.5e-03 5.6e-05 1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density3.25.67.92.02.82.62.52.62.62.82.42.7-0.5-1.5
Area under the delay curve0.91.02.1-1.0-1.3-1.4-1.2-1.2-1.0-1.0-1.1-0.60.40.3
BMI with tail3.110.815.8-3.2-3.7-3.6-3.3-3.6-3.7-4.0-3.3-3.9-0.11.3
BMI without tail1.03.04.8-1.6-2.1-1.9-1.3-1.7-1.8-2.1-1.6-2.20.91.3
Body weight0.31.24.1-2.0-0.9-1.70.0-0.7-0.8-1.1-0.4-1.5-0.10.6
Weight adjusted by age0.30.51.6-1.10.3-0.50.2-0.3-0.5-0.40.1-0.8-1.3-0.7
Bone surface2.34.26.21.52.52.31.92.01.92.31.92.2-1.4-2.2
Bone volume3.05.47.91.92.82.62.32.42.42.72.22.6-1.0-2.1
Breakpoint value in progressive ratio session0.50.61.1-1.1-0.6-0.8-1.0-0.8-1.0-1.0-0.3-0.9-0.6-0.3
Number of licking bursts0.20.30.50.70.50.70.70.60.60.60.50.50.40.1
Context. condit. distance diff. score0.60.81.8-0.2-1.0-0.7-0.4-0.8-0.7-1.0-0.6-1.21.31.0
Locomotion velocity, session 10.40.42.30.4-0.2-0.20.50.30.30.00.20.11.51.3
Locomotion distance, session 10.20.30.80.9-0.10.40.20.30.50.40.10.70.70.6
Locomotion velocity, session 20.40.51.20.40.80.31.10.90.80.61.10.60.10.3
Locomotion distance, session 20.20.20.91.0-0.20.5-0.6-0.3-0.2-0.2-0.4-0.00.6-0.3
Locomotion velocity, session 30.30.31.3-0.2-0.6-0.5-0.2-0.2-0.2-0.5-0.3-0.51.01.1
Locomotion distance, session 30.20.21.20.7-0.30.4-0.2-0.00.1-0.0-0.30.21.10.6
Stereotopy head waving bouts, day 32.63.15.21.62.32.01.21.71.82.01.72.1-0.2-1.7
Stereotopy head waving duration, day 31.82.13.31.01.81.21.51.71.71.71.71.70.2-0.6
Locomotion velocity, session 70.20.20.80.70.30.60.20.30.30.20.20.10.90.2
Locomotion distance, session 70.81.01.4-0.4-1.2-0.7-1.1-1.1-1.0-1.2-0.9-1.11.11.1
Stereotopy head waving bouts, day 72.52.84.30.82.11.41.91.91.82.01.71.9-0.8-1.2
Stereotopy head waving duration, day 73.33.95.91.52.31.92.32.32.32.42.02.3-0.0-0.8
Locomotion velocity, session 80.30.30.70.5-0.30.2-0.8-0.6-0.6-0.6-0.7-0.50.7-0.6
Locomotion distance, session 80.50.81.4-0.2-1.0-0.5-0.9-1.1-1.0-1.1-0.9-1.20.70.1
Degree of sensitization distance1.41.42.3-1.5-1.0-1.3-1.2-1.4-1.4-1.3-1.0-1.4-0.9-0.4
Degree of sensitization stereotypy0.80.91.70.51.10.91.31.11.11.10.90.9-0.6-0.6
Conditioned locomotion0.10.10.50.60.20.40.50.30.40.20.20.10.70.2
Cocaine response after cond. corrected2.53.14.7-1.3-1.9-1.4-2.1-2.1-2.1-2.0-2.2-1.9-0.60.0
Cocaine response after cond. not corrected4.14.86.9-1.7-2.5-1.9-2.4-2.6-2.6-2.6-2.5-2.6-0.50.5
Cocaine response before conditioning0.50.61.0-0.8-0.9-0.9-0.5-0.7-0.8-1.0-0.4-0.90.21.0
Saline control response0.50.72.0-1.4-0.7-1.0-0.4-0.6-0.7-0.7-0.5-0.6-1.3-0.1
Bone: connectivity density2.43.75.11.82.22.21.92.22.12.21.92.20.0-1.0
Bone: cortical apparent density3.54.86.32.42.32.32.32.42.52.52.42.41.0-0.3
Bone: cortical area1.21.83.20.21.70.81.81.51.31.41.81.2-1.2-0.8
Bone: cortical porosity0.20.30.7-0.7-0.3-0.5-0.4-0.5-0.5-0.4-0.4-0.3-0.8-0.5
Bone: cortical porosity1.01.12.6-1.6-0.7-1.3-0.8-1.0-1.1-1.0-0.8-0.9-1.6-0.5
Bone: cortical thickness1.62.64.61.11.91.42.12.01.81.82.11.50.0-0.3
Bone: cortical thickness0.91.02.40.50.50.21.51.11.10.71.20.51.11.5
Bone: cortical tissue density2.94.05.42.12.12.12.12.22.32.32.22.21.0-0.2
Condit. Reinf. active minus inactive responses0.20.20.4-0.10.5-0.10.50.60.40.40.70.5-0.1-0.1
Condit. Reinf. active-inactive response ratio1.31.42.20.91.10.81.51.51.41.31.41.30.90.4
Condit. Reinf. active responses0.00.00.1-0.2-0.1-0.2-0.1-0.1-0.2-0.2-0.0-0.2-0.3-0.3
Condit. Reinf. inactive responses1.51.82.9-0.7-1.4-0.8-1.7-1.6-1.7-1.6-1.6-1.6-0.6-0.2
Incentive salience index mean0.20.20.5-0.10.60.20.60.50.40.40.60.4-0.6-0.7
Condit. Reinf. lever presses0.20.30.70.10.70.40.90.60.50.50.70.3-0.6-0.7
Condit. Reinf. active minus inactive responses0.30.41.9-0.50.1-0.2-0.6-0.3-0.30.1-0.10.3-1.3-1.4
Condit. Reinf. active-inactive response ratio0.00.00.20.00.1-0.1-0.10.20.10.30.20.4-0.2-0.3
Condit. Reinf. active responses0.40.61.4-1.1-0.5-0.8-0.8-0.7-0.8-0.5-0.5-0.3-1.2-0.7
Condit. Reinf. inactive responses0.81.01.5-1.1-1.2-1.2-0.9-1.1-1.1-1.2-1.0-1.10.00.6
Condit. Reinf. lever presses0.20.31.0-1.0-0.1-0.6-0.2-0.3-0.5-0.30.0-0.3-0.9-0.5
Condit. Reinf. lever reinforcers received0.40.62.0-0.9-0.3-0.6-0.7-0.6-0.7-0.3-0.4-0.2-1.4-1.1
Conditioned reinforcement - actives0.20.41.5-1.2-0.1-1.20.0-0.1-0.3-0.2-0.1-0.2-0.8-0.6
Conditioned reinforcement - inactives1.62.35.80.41.80.42.42.01.81.72.01.40.20.2
Conditioned locomotion1.01.33.2-1.6-1.1-1.8-0.6-1.0-1.1-1.3-0.6-1.30.01.0
Patch foraging indifference point 0 sec0.20.41.7-1.3-0.4-0.7-0.2-0.3-0.4-0.3-0.4-0.4-1.20.1
Patch foraging indifference point AUC0.40.63.90.40.70.7-0.10.20.20.40.10.6-0.6-2.0
Delay disc. indifference point, 0s delay1.11.23.7-1.4-0.6-1.0-0.7-1.0-1.0-0.7-0.6-0.4-1.9-1.7
Delay disc. indifference point, 16s delay0.50.61.2-0.4-0.9-0.7-1.1-0.9-0.8-0.7-1.1-0.50.1-0.6
Delay disc. indifference point, 2s delay0.91.02.1-1.1-1.1-1.5-1.2-1.1-1.0-0.7-1.0-0.0-0.8-0.3
Delay disc. indifference point, 24s delay0.70.82.0-0.5-0.9-1.2-0.6-0.6-0.6-0.8-0.6-0.81.41.1
Delay disc. indifference point, 4s delay0.10.10.5-0.5-0.0-0.70.0-0.3-0.2-0.10.10.1-0.0-0.3
Delay disc. indifference point, 8s delay1.61.83.2-1.0-1.8-1.4-1.6-1.5-1.3-1.4-1.4-1.01.11.3
Indifference point function ln k1.62.84.9-2.2-1.9-2.2-1.2-1.6-1.7-1.8-1.5-1.8-0.71.2
Indifference point function log k1.62.84.9-2.2-1.9-2.2-1.2-1.6-1.7-1.8-1.5-1.8-0.71.2
Patch foraging total patch changes 0 sec0.20.31.4-1.2-0.4-0.6-0.0-0.2-0.3-0.2-0.3-0.2-1.10.3
Patch foraging total patch changes 12 sec0.20.31.1-0.60.5-0.00.10.40.20.40.30.6-1.0-0.9
Patch foraging total patch changes 18 sec1.01.63.10.71.41.01.21.41.41.61.31.8-0.2-0.9
Patch foraging total patch changes 24 sec0.91.53.00.71.41.11.11.41.41.61.11.7-0.5-1.0
Patch foraging total patch changes 6 sec0.30.41.6-0.30.60.30.60.50.40.60.30.5-1.1-1.2
Patch foraging time to switch 0 sec0.40.81.71.31.21.20.50.90.80.90.90.80.3-0.7
Patch foraging water rate 0 sec0.71.52.5-1.6-1.5-1.3-0.8-1.3-1.2-1.4-1.4-1.4-0.60.5
Patch foraging water rate 12 sec2.14.59.2-3.0-2.5-2.7-1.5-2.1-2.1-2.0-2.1-2.0-1.50.8
Patch foraging water rate 18 sec3.14.78.0-2.8-2.5-2.4-1.6-2.2-2.2-2.3-2.2-2.5-1.60.9
Patch foraging water rate 24 sec2.02.85.5-2.3-1.8-2.2-1.0-1.5-1.6-1.8-1.3-1.8-0.51.7
Patch foraging water rate 6 sec0.40.62.1-1.5-0.7-1.20.4-0.3-0.3-0.4-0.1-0.7-0.71.0
Seeking ratio, delayed vs. immediate footshock0.50.61.70.9-0.10.9-1.0-0.6-0.5-0.2-0.9-0.3-0.4-1.3
Distance traveled before self-admin0.91.22.61.61.31.50.81.01.01.01.31.00.7-0.0
Distance traveled after self-admin0.10.10.5-0.00.00.00.30.30.20.10.40.20.50.7
Extensor digitorum longus weight0.10.51.50.4-0.50.2-0.8-0.9-0.8-0.9-0.7-1.20.4-0.3
Bone: elastic displacement0.30.41.3-1.1-0.6-1.1-0.2-0.2-0.3-0.3-0.4-0.1-0.60.8
Bone: elastic work0.50.72.1-0.51.0-0.01.41.00.80.81.10.5-0.70.1
Bone: endosteal estimation0.20.41.6-0.50.70.10.70.40.30.40.70.2-1.3-0.7
Bone: endosteal perimeter0.61.38.3-1.10.5-0.2-0.1-0.1-0.30.20.00.3-2.9-2.1
Epididymis fat weight0.72.53.5-1.7-1.4-1.3-1.8-1.7-1.9-1.5-1.7-1.4-1.6-1.2
Delta time in closed arm before/after self-admin1.51.42.6-1.2-1.4-1.6-1.1-1.1-1.2-1.2-1.2-1.00.31.0
Delta time in open arm before/after self-admin0.30.30.60.20.80.00.50.50.50.70.50.5-0.6-0.7
Diff in mean of infusions in LGA sessions0.60.72.4-1.50.0-1.2-0.5-0.4-0.6-0.4-0.1-0.4-1.5-0.9
Delay discount exponential model param1.01.12.40.91.31.51.11.11.01.11.00.7-0.8-0.7
Extinction: sum of active levers before priming1.41.62.9-1.6-1.2-1.3-1.7-1.3-1.5-1.4-1.1-0.9-0.8-0.3
Active lever presses in extinction session 63.33.35.0-1.8-1.8-1.8-2.0-2.1-2.1-2.2-1.8-2.2-0.50.0
Bone: final force4.87.713.51.93.42.43.63.33.23.03.72.50.6-0.2
Bone: final moment4.67.513.01.93.42.43.53.33.13.03.62.50.6-0.2
Food consumed during 24 hour testing period0.30.51.2-1.1-0.6-1.1-0.1-0.5-0.6-0.8-0.5-0.9-0.10.5
Glucose0.10.10.4-0.4-0.2-0.1-0.2-0.2-0.2-0.1-0.30.1-0.7-0.3
Heart weight0.20.30.80.2-0.10.20.90.60.60.40.10.30.90.7
Delay discount hyperbolic model param0.80.92.20.81.21.51.01.10.90.90.90.5-0.8-0.6
Intermittent access intake day 1-15 change0.30.62.2-1.4-0.4-1.0-0.1-0.5-0.6-0.5-0.3-0.6-1.5-0.1
Intermittent access intake escalation0.30.62.7-1.6-0.2-1.10.3-0.2-0.4-0.2-0.2-0.4-1.6-0.1
Intermittent access intake escalation 21.31.58.5-1.90.4-0.80.5-0.1-0.30.1-0.0-0.1-2.9-1.7
Intermitt. access day 1 inactive lever presses0.31.34.4-0.71.1-0.32.11.41.21.21.41.1-0.70.1
Intermitt. access day 15 inactive lever presses0.20.42.1-0.50.2-0.11.50.60.50.30.5-0.2-0.30.8
Intermitt. access escalation Index0.10.20.6-0.5-0.7-0.6-0.5-0.2-0.2-0.2-0.5-0.0-0.20.8
Intermittent access day 1 total infusions0.40.63.5-0.7-0.8-0.9-0.2-0.2-0.2-0.5-0.3-0.41.01.9
Intermittent access day 15 total infusions0.30.51.8-1.3-0.3-0.90.40.1-0.1-0.20.0-0.2-0.31.4
Intermittent access terminal intake (last 3 days)1.11.45.3-2.3-0.8-1.7-0.5-0.8-1.0-1.0-0.7-1.0-1.20.7
Intermittent access total infusions0.60.72.4-1.5-0.7-1.3-0.2-0.3-0.4-0.6-0.3-0.50.01.5
Intermittent access day 1 locomotion0.40.62.4-1.00.0-0.90.70.60.50.30.60.50.31.5
Intermittent access day 15 total locomotion0.40.73.1-1.3-0.1-1.20.80.30.1-0.00.5-0.10.01.8
Intermittent access total locomotion0.81.03.8-1.6-0.8-1.6-0.2-0.4-0.5-0.7-0.3-0.70.22.0
Intermittent access standard deviation0.20.30.8-0.4-0.4-0.3-0.7-0.7-0.7-0.7-0.5-0.9-0.2-0.4
Left kidney weight1.46.617.8-4.2-2.2-3.4-1.2-2.3-2.6-2.6-2.0-3.1-2.3-0.3
Right kidney weight2.712.127.2-5.2-3.4-4.5-1.9-3.3-3.5-3.7-3.0-4.3-2.30.4
Cocaine induced anxiety2.63.75.5-2.0-1.9-1.5-2.3-2.3-2.3-2.2-1.9-2.2-1.1-0.3
Post-drug Anxiety4.44.78.7-1.3-2.2-1.3-2.9-2.7-2.7-2.6-2.4-2.7-0.4-0.3
Baseline Anxiety0.40.52.71.70.21.1-0.20.10.20.2-0.10.21.0-0.3
Tail length2.07.712.31.83.22.63.53.23.23.33.02.9-0.3-1.6
Length with tail1.14.610.90.12.51.23.32.52.52.62.42.0-1.2-1.4
Length without tail0.41.25.1-1.90.5-0.91.10.40.30.50.40.2-2.3-1.1
Times rat made contact with spout2.83.25.0-1.9-2.1-2.2-1.3-1.7-1.7-2.0-1.6-2.10.31.9
Lifetime Intake0.81.03.3-1.6-1.0-1.4-0.2-0.3-0.5-0.8-0.4-0.70.51.8
Liver weight, left0.10.20.7-0.4-0.0-0.2-0.4-0.4-0.5-0.4-0.2-0.4-0.6-0.8
Liver weight, right0.10.20.6-0.8-0.1-0.60.50.20.20.20.10.3-0.70.1
Locomotor activity0.81.23.5-1.6-0.9-1.2-1.0-0.9-1.0-0.8-1.1-0.6-1.9-0.4
Locomotor testing distance0.10.20.7-0.2-0.5-0.3-0.8-0.5-0.4-0.3-0.6-0.1-0.30.5
Locomotor testing rearing0.30.53.0-1.2-0.1-0.7-0.4-0.3-0.4-0.1-0.20.1-1.7-0.4
Locomotion in novel chamber0.70.92.50.90.80.61.61.01.00.61.10.11.00.7
Locomotion in novel chamber post-restriction0.10.20.70.10.60.40.00.20.10.30.30.5-0.8-0.7
Fecal boli incidents, locomotor time 10.20.21.7-0.0-0.00.10.30.20.30.10.20.30.71.3
Change in fecal boli incidents, locomotor task0.70.72.7-0.9-0.6-0.6-0.6-0.7-0.7-0.5-1.0-0.7-1.6-0.9
Time >=10cm from walls, locomotor time 10.50.52.7-0.20.50.2-0.4-0.3-0.30.1-0.3-0.1-1.4-1.6
Bouts of movement, locomotor time 11.61.83.21.11.11.31.81.61.61.51.81.10.7-0.2
Total resting periods, locomotor time 12.32.54.31.41.31.72.11.91.91.82.01.40.9-0.2
Rest time, locomotor task time 10.81.03.90.3-0.10.71.20.91.00.60.60.71.22.0
Distance moved, locomotor task time 10.91.42.1-1.0-0.8-1.4-1.5-1.3-1.3-1.0-1.5-0.8-1.2-0.9
Vertical activity count, locomotor time 10.51.32.5-1.6-0.3-1.5-1.0-1.0-1.2-0.8-0.8-0.8-1.3-1.3
Time >=10cm from walls, locomotor time 20.50.73.2-1.1-0.5-0.7-0.3-0.7-0.7-0.6-0.6-0.7-1.8-0.6
Bouts of movement, locomotor time 20.40.61.40.60.60.51.20.90.90.90.60.80.60.3
Total resting periods, locomotor time 20.50.81.80.60.80.71.31.11.11.10.71.10.50.4
Rest time, locomotor task time 20.30.42.1-0.1-0.10.20.50.50.70.5-0.10.60.81.5
Distance moved, locomotor task time 20.81.01.7-0.9-0.8-0.8-0.9-1.3-1.3-1.2-0.9-1.2-0.8-0.3
Vertical activity count, locomotor time 20.71.01.8-1.4-0.7-1.2-0.8-1.1-1.2-1.1-0.6-1.0-0.9-0.8
Light reinforcement 11.53.85.8-2.0-2.2-2.0-2.2-2.2-2.2-1.9-2.4-1.6-1.4-0.3
Light reinforcement 23.85.98.5-2.9-2.4-2.6-2.2-2.6-2.7-2.4-2.7-2.1-2.6-0.9
Bone: marrow area0.20.41.4-0.40.80.20.80.40.40.50.80.3-1.2-0.7
Bone: maximum diameter0.10.21.6-0.7-0.0-0.30.2-0.0-0.1-0.10.1-0.1-1.3-0.3
Bone: maximum force2.64.58.51.42.71.92.92.52.42.22.91.80.4-0.2
Bone: maximum moment2.64.58.31.42.71.92.82.52.42.22.91.70.3-0.2
Mean time between licks in bursts5.613.820.93.54.03.44.44.34.34.04.63.72.10.6
Mean num. licks in bursts1.42.23.7-1.9-1.7-1.9-1.4-1.5-1.6-1.6-1.4-1.6-0.60.7
Cd content in liver0.10.10.30.00.10.10.20.20.20.20.10.30.50.4
Co content in liver0.30.31.3-0.8-0.4-0.4-0.4-0.5-0.5-0.4-0.5-0.3-1.2-0.5
Cu content in liver1.01.15.11.1-0.10.50.50.60.80.40.40.32.32.0
Fe content in liver0.81.02.0-1.4-1.4-1.3-0.9-0.9-0.9-0.8-1.3-0.5-0.40.6
K content in liver0.40.41.61.00.51.1-0.20.10.30.50.00.5-0.2-1.3
Mg content in liver0.60.61.80.5-0.30.5-1.3-0.7-0.6-0.3-0.8-0.1-0.9-1.3
Mn content in liver0.30.32.00.40.30.8-0.5-0.2-0.20.1-0.30.2-0.7-1.4
Na content in liver3.13.45.92.12.12.41.11.61.72.11.32.3-0.2-2.1
Rb content in liver0.80.91.4-1.0-1.0-0.9-1.1-1.0-1.0-0.8-1.1-0.6-1.2-0.2
Se content in liver0.60.71.3-0.9-1.0-0.9-0.9-0.9-0.9-0.9-1.1-0.90.10.4
Sr content in liver2.62.33.01.51.31.21.71.71.71.61.61.51.70.9
Zn content in liver0.50.63.00.4-0.5-0.10.20.20.3-0.00.10.01.71.7
Bone: minimum diameter0.50.91.70.31.20.71.21.00.91.01.30.9-0.8-0.7
Time in familiar zone, hab. session 10.60.62.7-0.80.1-0.81.00.60.50.20.80.00.71.7
Time in novel zone, hab. session 10.30.31.20.90.20.9-0.4-0.00.00.3-0.30.6-0.3-1.1
Total zone transitions, hab. session 10.20.31.41.20.10.9-0.5-0.20.00.2-0.30.20.4-0.9
Total locomotion distance, hab. session 10.40.60.9-0.7-0.7-0.7-0.9-0.9-0.9-0.8-0.8-0.8-0.9-0.5
Locomotion velocity, hab. session 10.71.01.5-0.8-1.0-0.8-1.2-1.2-1.1-1.0-1.1-1.0-1.0-0.6
Time in familiar zone, hab. session 20.40.42.0-0.7-0.3-0.80.70.20.2-0.10.3-0.30.81.4
Time in novel zone, hab. session 20.40.41.51.20.41.1-0.20.20.30.40.00.7-0.1-0.9
Total zone transitions, hab. session 21.92.54.1-0.8-2.0-1.6-1.6-1.7-1.6-1.8-1.7-1.71.01.3
Total locomotion distance, hab. session 23.03.95.7-1.8-2.4-2.2-1.9-2.3-2.2-2.3-2.1-2.3-0.11.0
Locomotion velocity, hab. session 23.04.05.6-1.9-2.3-2.2-2.0-2.3-2.2-2.4-2.1-2.3-0.40.7
Novel to familiar place preference ratio0.80.91.51.20.91.10.70.91.01.00.91.00.90.2
Novelty place preference0.60.61.11.00.70.80.60.80.80.70.70.80.90.4
Time in novel zone, NPP test0.80.81.41.20.80.90.80.91.00.80.90.81.20.6
Total zone transitions, NPP test0.30.51.00.4-0.70.0-1.0-0.9-0.7-0.7-0.9-0.60.6-0.1
Total locomotion distance, NPP test1.11.52.4-0.8-1.4-0.9-1.6-1.5-1.4-1.4-1.5-1.3-0.4-0.1
Locomotion velocity, NPP test1.21.72.8-0.8-1.4-0.9-1.7-1.6-1.5-1.5-1.6-1.4-0.5-0.3
Intraocular pressure0.30.41.2-0.5-0.9-0.6-0.8-0.5-0.6-0.6-0.6-0.10.01.1
Delta distance traveled before/after self-admin0.91.02.9-1.6-1.1-1.7-0.2-0.5-0.6-0.9-0.8-0.90.11.1
Delta ambulatory time before/after self-admin0.70.92.2-1.2-1.2-1.5-0.4-0.6-0.6-0.9-0.8-0.90.61.0
Parametrial fat weight0.10.20.4-0.4-0.5-0.4-0.6-0.6-0.6-0.6-0.5-0.60.1-0.2
Pavlov. Cond. lever latency0.00.10.20.3-0.10.1-0.4-0.1-0.1-0.0-0.2-0.00.40.2
Pavlov. Cond. magazine entry latency1.11.42.21.01.31.01.31.41.31.31.51.40.4-0.0
Pavlov. Cond. change in total contacts0.90.91.91.40.81.20.80.91.01.00.91.20.8-0.1
Pavlov. Cond. index score0.50.60.80.80.80.80.80.80.80.80.80.90.4-0.1
Pavlov. Cond. latency score0.40.60.80.70.90.90.90.80.80.80.80.80.0-0.4
Pavlov. Cond. lever contacts0.00.00.20.10.10.10.40.20.20.10.20.20.00.0
Pavlov. Cond. magazine entry number0.30.41.0-0.6-0.5-0.5-0.5-0.7-0.7-0.7-0.6-1.0-0.3-0.3
Pavlov. Cond. intertrial magazine entries0.70.91.4-1.1-1.1-1.2-0.9-1.0-1.1-1.1-0.9-1.0-0.50.1
Pavlov. Cond. lever-magazine prob. diff.0.50.60.91.00.81.00.80.80.90.80.80.90.4-0.1
Pavlov. Cond. response bias0.00.10.10.00.1-0.00.30.30.20.20.30.40.20.4
Pavlov. Cond. lever latency0.40.51.01.00.70.70.50.80.90.80.50.90.40.3
Pavlov. Cond. magazine entry latency0.81.02.20.21.20.71.51.21.01.01.40.7-0.5-0.5
Pavlov. Cond. change in total contacts0.20.31.9-0.20.00.2-0.3-0.2-0.3-0.0-0.2-0.1-0.9-1.4
Pavlov. Cond. index score0.10.20.7-0.80.0-0.20.2-0.1-0.2-0.10.1-0.4-0.8-0.6
Pavlov. Cond. latency score0.20.30.8-0.8-0.1-0.3-0.0-0.3-0.4-0.3-0.1-0.6-0.9-0.7
Pavlov. Cond. lever contacts0.40.51.3-1.2-0.7-0.8-0.4-0.8-0.9-0.8-0.5-1.0-0.4-0.1
Pavlov. Cond. magazine entry number0.60.71.90.1-1.0-0.5-1.4-1.0-0.8-0.8-1.1-0.40.60.5
Pavlov. Cond. intertrial magazine entries2.64.06.3-2.1-2.4-2.5-2.2-2.1-2.1-2.2-2.1-1.8-0.21.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.6-0.80.0-0.20.3-0.0-0.2-0.10.2-0.4-0.8-0.6
Pavlov. Cond. response bias0.10.10.4-0.40.30.00.60.30.20.30.50.1-0.5-0.3
Time in closed arm before self-admin2.63.46.41.21.91.71.91.92.02.31.52.5-1.4-1.5
Time in closed arm after self-admin0.20.31.5-0.70.1-0.40.10.20.00.3-0.00.6-1.2-0.6
Time in open arm before self-admin0.50.51.70.7-0.10.6-1.0-0.6-0.5-0.7-0.4-0.91.30.0
Time in open arm after self-admin0.10.10.4-0.1-0.1-0.2-0.6-0.4-0.5-0.4-0.3-0.5-0.2-0.3
Bone: periosteal estimation0.61.22.5-0.31.30.51.51.10.91.11.40.8-1.6-0.9
Bone: periosteal perimeter0.81.36.1-0.81.20.21.00.80.50.81.00.7-2.5-1.7
Bone: post-yield work1.11.62.81.01.10.91.61.51.51.31.71.01.31.0
Progressive ratio test 1 active lever presses0.60.72.90.50.40.10.80.80.80.40.90.21.71.2
Progressive ratio test 1 breakpoint0.60.72.70.50.40.20.80.80.80.50.90.31.71.0
Progressive ratio test 1 inactive lever presses1.92.77.4-0.31.7-0.02.72.32.01.91.91.7-0.30.1
Progressive ratio test 2 active lever presses0.30.31.5-1.0-0.2-1.20.60.20.1-0.10.3-0.30.30.7
Progressive ratio test 2 breakpoint0.30.31.2-0.9-0.0-1.10.70.30.20.00.4-0.10.40.8
Progressive ratio test 2 inactive lever presses0.40.62.1-1.00.4-0.71.50.80.70.50.80.3-0.30.7
Incentive Sensitization - Responses0.30.41.6-1.3-0.1-1.20.3-0.1-0.3-0.30.0-0.3-0.8-0.1
Incentive Sensitization - Breakpoint0.20.31.3-1.1-0.1-1.10.4-0.0-0.2-0.10.2-0.2-0.70.0
Sum of active levers in priming session hrs 5-60.20.20.4-0.50.4-0.4-0.5-0.0-0.3-0.40.7-0.20.30.0
Progressive ratio0.10.20.6-0.1-0.2-0.5-0.6-0.5-0.5-0.6-0.1-0.80.40.0
Food seeking constrained by brief footshock7.28.813.0-2.6-3.4-2.8-3.3-3.5-3.4-3.6-3.1-3.40.01.2
Seeking ratio, punishment vs. effort0.71.02.0-1.0-1.2-0.7-1.2-1.2-1.1-1.1-1.4-0.8-0.70.0
Retroperitoneal fat weight1.35.77.8-2.5-2.7-2.8-2.3-2.7-2.7-2.8-2.4-2.7-0.20.6
Reaction time number correct0.10.21.50.1-0.2-0.20.40.20.30.10.20.20.71.2
Reaction time mean minus median0.10.30.60.30.60.50.50.70.50.50.80.50.2-0.1
Reaction time mean minus median AUC0.00.00.1-0.00.10.0-0.10.1-0.1-0.10.3-0.10.0-0.2
Reaction time num false alarms0.40.61.00.80.81.00.70.90.80.80.70.8-0.2-0.2
Reaction time num false alarms AUC0.10.10.30.60.20.50.20.40.40.20.30.20.40.5
Reaction time trials correct on left0.10.21.50.1-0.2-0.20.40.20.30.10.20.20.71.2
Reaction time trials on left0.10.31.40.2-0.1-0.00.60.30.40.20.40.30.81.2
Reaction time mean1.11.82.71.61.41.51.31.51.41.31.61.11.20.3
Reaction time mean AUC1.32.13.11.81.51.71.41.61.51.41.71.21.10.1
Median of all reaction times1.42.03.21.81.41.61.41.61.51.31.61.11.30.5
Reaction time omissions2.84.17.52.72.12.51.92.12.01.82.21.62.00.3
Reaction time false alarm rate0.10.20.50.60.50.70.10.40.30.40.20.3-0.2-0.5
Reaction time premature initiation rate1.92.66.9-2.1-1.1-1.4-1.3-1.4-1.6-1.2-1.5-1.1-2.6-1.7
Reaction time premature initiations0.81.43.3-1.6-0.9-1.1-0.9-1.1-1.2-1.0-1.1-0.8-1.8-0.9
Std. dev. reaction times0.61.02.21.01.11.01.11.21.00.91.50.71.00.3
Reaction time trials completed0.10.31.40.2-0.1-0.00.60.30.40.20.40.30.81.2
Reaction time trials AUC0.10.31.60.1-0.1-0.10.60.30.40.20.40.20.71.3
Run reversals in cocaine runway, females0.40.41.10.40.50.11.00.80.70.60.80.40.70.8
Run reversals in cocaine runway, males0.50.54.2-0.4-0.4-0.3-0.20.1-0.0-0.20.30.20.42.0
Latency to leave start box in cocaine runway1.11.32.5-0.4-1.0-1.3-0.8-1.0-1.1-1.5-0.2-1.61.31.3
Latency to leave start box in cocaine runway, F1.21.33.90.0-1.0-0.6-1.1-1.4-1.3-1.6-0.9-2.01.10.3
Latency to leave start box in cocaine runway, M0.60.62.9-0.8-0.5-1.3-0.1-0.1-0.2-0.40.6-0.10.61.7
Std. dev. time between licks in bursts0.81.01.7-1.1-0.9-1.1-0.9-1.2-1.2-1.2-0.8-1.3-0.9-0.3
Total sessions with >9 infusions1.01.26.3-0.7-0.3-0.90.60.40.2-0.30.6-0.32.22.5
Short access day 1 total inactive lever presses1.01.34.0-1.00.2-1.42.01.10.90.31.1-0.10.91.8
Short access day 10 total inactive lever presses0.81.98.1-2.30.0-1.80.7-0.3-0.5-0.3-0.1-0.6-2.8-1.7
Short access day 1 total infusions0.81.03.3-0.9-1.0-1.30.0-0.3-0.4-0.9-0.4-1.01.51.8
Short access day 10 total infusions1.11.44.2-1.9-1.1-2.0-0.1-0.4-0.6-0.9-0.2-0.90.62.1
Short access total infusions1.51.95.6-1.8-1.6-1.9-0.4-0.7-0.8-1.3-0.8-1.21.32.4
Short access day 1 locomotion0.30.41.1-0.9-0.4-0.80.70.10.1-0.30.0-0.40.71.0
Short access day 10 total locomotion0.40.83.2-0.90.1-1.21.10.60.40.10.9-0.00.71.8
Short access total locomotion1.01.14.8-1.10.2-1.31.20.80.60.21.10.11.22.2
One hour access (0.3 mA shock)1.31.56.4-2.5-0.7-1.7-0.2-0.7-0.9-0.6-0.7-0.6-2.0-0.2
Compulsive drug intake0.30.41.2-1.0-0.7-1.1-0.3-0.3-0.3-0.3-0.2-0.10.20.8
One hour access (shock baseline)0.40.72.5-1.6-0.4-1.0-0.2-0.5-0.6-0.5-0.6-0.5-1.5-0.3
Social response proportion0.10.10.3-0.10.30.10.10.20.30.40.40.6-0.4-0.2
Social responses0.00.10.2-0.3-0.2-0.0-0.4-0.3-0.2-0.0-0.20.1-0.3-0.2
Social time0.20.31.6-0.4-0.4-0.60.3-0.2-0.1-0.40.0-0.50.91.3
Soleus weight0.41.33.6-0.4-1.2-0.6-1.0-1.3-1.4-1.6-1.2-1.90.00.3
Bone: stiffness3.25.18.22.12.92.52.72.52.52.42.91.80.8-0.7
Tibialis anterior weight0.10.30.70.8-0.10.7-0.6-0.5-0.3-0.4-0.4-0.50.6-0.5
Time to tail flick, vehicle, before self-admin0.80.86.00.10.20.6-0.4-0.6-0.6-0.4-0.0-0.6-1.3-2.4
Time to tail flick, vehicle, after self-admin0.81.11.8-0.9-0.8-0.5-1.0-1.2-1.1-0.9-1.3-0.9-1.2-1.3
Time to tail flick, test, before self-admin0.60.62.80.30.90.60.50.50.40.70.80.6-0.9-1.7
Time to tail flick, test, after self-admin0.70.72.1-0.01.10.71.51.00.80.61.50.0-0.1-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.80.0-0.4-0.3-0.2-0.10.00.0-0.40.10.50.9
Delta time to tail flick, test, before/after SA0.50.52.00.20.40.51.00.60.60.20.9-0.10.91.4
Tibia length0.30.81.40.21.10.40.91.11.01.21.21.1-0.6-0.4
Ambulatory time before self-admin0.30.50.80.80.50.80.70.60.60.50.70.50.80.9
Ambulatory time after self-admin0.20.21.2-0.3-0.3-0.20.70.40.40.10.20.20.61.1
Bone: tissue strength0.70.71.20.81.00.81.00.80.90.71.10.40.70.1
Total heroin consumption0.81.02.1-0.9-1.0-0.7-1.4-1.1-1.2-1.3-0.5-1.1-0.00.3
Bone: trabecular number3.55.88.21.82.92.42.72.82.72.82.72.7-0.1-1.2
Bone: trabecular spacing6.18.111.6-2.0-3.4-2.7-3.2-3.4-3.3-3.4-3.3-3.30.11.0
Bone: trabecular thickness1.92.43.80.61.91.21.81.81.71.82.01.7-0.7-0.7
Bone: trabecular tissue density1.42.16.22.51.42.10.81.01.41.31.11.11.5-0.8
Water consumed over 24 hours1.01.42.0-1.4-1.2-1.2-1.1-1.3-1.3-1.3-1.2-1.3-0.8-0.2
Number of responses in last shaping day2.83.15.41.61.61.42.31.92.11.62.01.41.90.7