Hub : Genes

Suz12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XM_039087646.2 0.04 0.03 5.7e-05 0.03 0.04 0.03 0.03 1.8e-04 8.2e-05 1.1e-04 1.1e-04
2 NAcc gene expression Suz12 0.01 0.01 6.5e-03 0 0.01 0 0.01 6.4e-02 1.5e-02 1.7e-01 3.4e-02
3 PL mRNA stability Suz12 0.03 0.03 5.2e-03 0.02 0.02 0.02 0.02 4.6e-03 6.7e-03 4.6e-03 6.1e-03
4 pVTA gene expression Suz12 0.06 0.05 2.9e-04 0.05 0.05 0.05 0.05 6.3e-05 1.1e-04 5.1e-05 1.1e-04
5 Adipose gene expression Suz12 0.03 0.03 3.8e-03 0.01 0.01 0 0.01 5.6e-02 1.0e-02 1.6e-01 6.0e-02
6 Brain alternative TSS XM_039087646.2 0.03 0.03 4.1e-04 0.04 0.04 0.03 0.04 2.0e-04 2.7e-04 7.3e-04 2.4e-04
7 pVTA mRNA stability Suz12 0.09 0.06 1.9e-05 0.07 0.07 0.07 0.07 1.7e-06 4.4e-06 2.6e-06 4.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density2.24.14.9-2.22.21.9-2.02.22.01.7
Area under the delay curve0.00.00.10.2-0.3-0.30.1-0.10.10.1
BMI with tail0.72.43.0-1.31.51.7-1.61.51.41.7
BMI without tail0.31.92.1-1.31.41.5-1.31.41.31.4
Body weight2.310.312.2-3.43.53.1-3.13.33.02.9
Weight adjusted by age0.41.21.71.0-1.1-1.11.3-1.1-1.2-0.6
Bone surface0.50.91.3-1.11.10.9-1.01.11.00.4
Bone volume1.02.02.4-1.51.51.3-1.51.51.50.9
Breakpoint value in progressive ratio session0.61.11.9-1.41.41.0-0.91.10.80.8
Number of licking bursts0.10.20.50.7-0.7-0.40.2-0.4-0.10.1
Context. condit. distance diff. score0.20.30.4-0.60.60.4-0.40.60.40.6
Locomotion velocity, session 10.80.91.9-1.41.40.7-0.71.00.70.4
Locomotion distance, session 10.10.10.7-0.10.1-0.30.3-0.1-0.3-0.8
Locomotion velocity, session 20.00.00.0-0.10.20.00.10.1-0.1-0.2
Locomotion distance, session 20.40.60.8-0.80.90.9-0.70.90.70.4
Locomotion velocity, session 32.42.83.11.7-1.8-1.51.8-1.7-1.8-1.4
Locomotion distance, session 30.91.01.50.8-0.8-0.91.2-0.9-1.2-1.2
Stereotopy head waving bouts, day 30.10.10.30.2-0.2-0.40.5-0.3-0.5-0.1
Stereotopy head waving duration, day 30.20.30.30.6-0.5-0.50.6-0.5-0.5-0.3
Locomotion velocity, session 70.10.20.3-0.20.20.5-0.50.40.50.0
Locomotion distance, session 70.10.10.2-0.20.20.4-0.40.40.40.0
Stereotopy head waving bouts, day 70.30.30.7-0.90.90.4-0.20.60.20.2
Stereotopy head waving duration, day 70.10.10.3-0.60.60.10.00.3-0.00.0
Locomotion velocity, session 80.10.10.1-0.20.2-0.20.30.0-0.4-0.3
Locomotion distance, session 80.10.20.3-0.50.50.3-0.20.50.20.3
Degree of sensitization distance2.52.73.5-1.51.51.6-1.81.61.91.7
Degree of sensitization stereotypy0.60.71.2-1.11.10.8-0.60.90.60.6
Conditioned locomotion2.53.03.51.9-1.9-1.61.7-1.8-1.7-1.6
Cocaine response after cond. corrected1.21.92.5-1.11.21.6-1.61.41.41.2
Cocaine response after cond. not corrected1.92.73.4-1.51.51.8-1.91.71.71.4
Cocaine response before conditioning0.10.10.3-0.50.50.2-0.30.50.30.2
Saline control response0.10.10.10.3-0.3-0.30.3-0.3-0.3-0.3
Bone: connectivity density2.33.74.9-2.22.21.8-1.82.11.91.3
Bone: cortical apparent density0.00.00.10.4-0.4-0.1-0.1-0.10.0-0.1
Bone: cortical area0.91.52.71.6-1.6-1.01.0-1.4-0.8-0.5
Bone: cortical porosity0.10.10.10.3-0.3-0.20.2-0.2-0.30.2
Bone: cortical porosity0.10.10.10.3-0.3-0.00.1-0.2-0.10.4
Bone: cortical thickness1.52.54.42.1-2.1-1.41.3-1.8-1.2-0.9
Bone: cortical thickness0.10.10.20.4-0.40.1-0.2-0.10.3-0.2
Bone: cortical tissue density0.00.00.10.2-0.20.2-0.30.10.20.1
Condit. Reinf. active minus inactive responses0.10.10.30.4-0.50.10.1-0.2-0.10.1
Condit. Reinf. active-inactive response ratio0.20.20.30.5-0.6-0.30.4-0.5-0.5-0.2
Condit. Reinf. active responses0.10.10.30.1-0.10.4-0.30.10.30.5
Condit. Reinf. inactive responses0.10.10.4-0.20.30.3-0.30.20.30.6
Incentive salience index mean0.00.10.20.4-0.40.10.1-0.2-0.10.1
Condit. Reinf. lever presses0.10.10.3-0.30.30.5-0.30.30.30.5
Condit. Reinf. active minus inactive responses0.10.20.30.5-0.5-0.40.2-0.3-0.1-0.6
Condit. Reinf. active-inactive response ratio0.10.10.50.2-0.1-0.40.1-0.1-0.0-0.7
Condit. Reinf. active responses0.20.30.50.7-0.6-0.60.4-0.5-0.3-0.7
Condit. Reinf. inactive responses0.10.20.40.6-0.6-0.30.4-0.5-0.3-0.2
Condit. Reinf. lever presses0.60.91.31.1-1.2-0.90.7-0.9-0.6-1.1
Condit. Reinf. lever reinforcers received0.40.60.90.9-0.8-0.80.5-0.7-0.5-0.9
Conditioned reinforcement - actives0.10.20.30.3-0.1-0.60.6-0.4-0.5-0.4
Conditioned reinforcement - inactives0.82.23.21.0-0.8-1.71.7-1.3-1.8-1.8
Conditioned locomotion1.32.02.80.9-0.7-1.61.7-1.3-1.6-1.6
Patch foraging indifference point 0 sec0.00.00.10.2-0.30.2-0.2-0.00.2-0.0
Patch foraging indifference point AUC1.02.53.01.7-1.7-1.61.6-1.6-1.5-1.3
Delay disc. indifference point, 0s delay0.50.60.80.9-0.9-0.80.7-0.8-0.7-0.7
Delay disc. indifference point, 16s delay0.10.20.5-0.30.20.0-0.40.30.70.5
Delay disc. indifference point, 2s delay0.70.81.10.9-1.0-1.10.8-0.9-0.7-0.6
Delay disc. indifference point, 24s delay0.10.10.2-0.20.20.3-0.40.30.40.4
Delay disc. indifference point, 4s delay1.41.52.6-1.10.91.3-1.21.21.21.6
Delay disc. indifference point, 8s delay0.10.10.2-0.30.2-0.0-0.20.30.40.4
Indifference point function ln k2.36.98.4-2.52.32.9-2.82.62.82.4
Indifference point function log k2.36.98.4-2.52.32.9-2.82.62.82.4
Patch foraging total patch changes 0 sec0.00.00.10.2-0.30.1-0.1-0.10.1-0.1
Patch foraging total patch changes 12 sec0.20.30.40.5-0.5-0.60.6-0.6-0.5-0.6
Patch foraging total patch changes 18 sec0.40.91.41.2-1.2-0.90.8-1.0-0.7-0.8
Patch foraging total patch changes 24 sec0.41.31.71.3-1.3-1.01.1-1.3-0.9-1.1
Patch foraging total patch changes 6 sec1.93.34.01.9-2.0-1.71.7-1.9-1.7-1.7
Patch foraging time to switch 0 sec0.00.20.5-0.50.7-0.40.40.1-0.4-0.1
Patch foraging water rate 0 sec0.20.71.51.1-1.2-0.50.5-0.8-0.5-0.6
Patch foraging water rate 12 sec0.31.31.9-1.10.91.3-1.41.11.40.8
Patch foraging water rate 18 sec1.33.03.6-1.61.51.9-1.91.71.91.6
Patch foraging water rate 24 sec0.40.50.9-0.30.11.0-0.90.61.00.6
Patch foraging water rate 6 sec0.00.10.20.3-0.40.2-0.2-0.10.20.0
Seeking ratio, delayed vs. immediate footshock0.30.41.01.0-1.00.3-0.1-0.40.10.8
Distance traveled before self-admin0.91.92.31.4-1.5-1.41.5-1.5-1.4-0.8
Distance traveled after self-admin0.00.00.10.2-0.2-0.10.0-0.10.0-0.3
Extensor digitorum longus weight0.10.30.5-0.70.70.4-0.30.50.40.5
Bone: elastic displacement0.30.41.21.1-1.1-0.20.1-0.6-0.0-0.1
Bone: elastic work4.45.88.62.9-2.9-2.22.1-2.6-1.9-2.0
Bone: endosteal estimation0.10.20.40.3-0.3-0.60.5-0.5-0.5-0.6
Bone: endosteal perimeter0.10.20.3-0.60.50.5-0.50.50.50.3
Epididymis fat weight5.829.131.9-5.65.65.3-5.45.55.25.1
Delta time in closed arm before/after self-admin0.10.10.40.3-0.50.2-0.1-0.00.50.6
Delta time in open arm before/after self-admin0.81.02.2-1.31.50.7-0.91.10.60.3
Diff in mean of infusions in LGA sessions0.10.20.7-0.70.8-0.20.30.2-0.3-0.2
Delay discount exponential model param0.00.00.00.00.10.20.1-0.0-0.2-0.2
Extinction: sum of active levers before priming0.10.20.7-0.50.6-0.30.10.1-0.2-0.9
Active lever presses in extinction session 60.30.30.50.1-0.1-0.50.7-0.5-0.7-0.6
Bone: final force0.30.51.01.0-1.0-0.50.5-0.8-0.5-0.6
Bone: final moment0.30.51.01.0-1.0-0.50.6-0.8-0.5-0.6
Food consumed during 24 hour testing period0.20.50.60.7-0.7-0.60.8-0.7-0.7-0.5
Glucose0.40.71.61.3-1.2-0.50.6-0.9-0.5-0.3
Heart weight1.11.82.3-1.21.11.4-1.41.31.41.5
Delay discount hyperbolic model param0.00.00.1-0.10.30.2-0.00.1-0.1-0.1
Intermittent access intake day 1-15 change0.10.40.70.8-0.8-0.50.5-0.6-0.7-0.6
Intermittent access intake escalation0.10.40.60.8-0.8-0.40.6-0.6-0.6-0.5
Intermittent access intake escalation 20.30.40.80.8-0.9-0.50.5-0.6-0.6-0.6
Intermitt. access day 1 inactive lever presses0.11.21.71.0-1.0-1.01.1-1.1-1.3-1.2
Intermitt. access day 15 inactive lever presses1.05.67.12.1-1.9-2.62.5-2.4-2.7-2.4
Intermitt. access escalation Index0.20.71.9-1.31.40.3-0.30.90.50.6
Intermittent access day 1 total infusions0.20.50.90.1-0.0-0.90.8-0.6-0.8-0.9
Intermittent access day 15 total infusions0.40.91.80.5-0.4-1.11.1-0.8-1.1-1.3
Intermittent access terminal intake (last 3 days)0.20.30.6-0.20.3-0.70.6-0.2-0.6-0.8
Intermittent access total infusions0.40.50.80.3-0.3-0.90.8-0.6-0.8-0.9
Intermittent access day 1 locomotion0.91.72.30.9-0.8-1.51.5-1.3-1.4-1.5
Intermittent access day 15 total locomotion0.52.02.71.1-1.0-1.51.6-1.4-1.7-1.6
Intermittent access total locomotion1.31.52.20.9-0.9-1.31.3-1.2-1.5-1.5
Intermittent access standard deviation0.41.92.41.3-1.2-1.61.4-1.4-1.3-1.4
Left kidney weight0.10.50.7-0.70.80.7-0.70.80.80.5
Right kidney weight0.00.30.5-0.60.70.4-0.50.50.40.7
Cocaine induced anxiety0.20.50.8-0.60.60.5-0.70.60.90.7
Post-drug Anxiety0.91.11.7-1.21.30.7-0.91.11.10.8
Baseline Anxiety0.20.40.70.3-0.1-0.70.7-0.5-0.7-0.8
Tail length0.31.62.3-1.51.51.1-1.21.41.20.9
Length with tail1.25.48.1-2.82.72.1-2.22.52.11.7
Length without tail0.73.64.5-2.12.11.9-2.01.91.71.6
Times rat made contact with spout0.20.20.4-0.30.20.7-0.60.40.50.3
Lifetime Intake0.70.91.70.3-0.2-1.21.1-0.8-1.1-1.3
Liver weight, left3.76.49.3-3.03.12.2-2.32.62.22.2
Liver weight, right4.68.110.4-3.23.22.6-2.72.92.52.7
Locomotor activity0.71.12.0-0.70.71.2-1.41.01.21.0
Locomotor testing distance0.20.51.2-0.40.40.9-1.10.70.80.6
Locomotor testing rearing0.00.10.20.2-0.10.2-0.40.20.30.1
Locomotion in novel chamber0.81.02.01.3-1.4-0.80.9-1.2-0.9-0.2
Locomotion in novel chamber post-restriction1.13.54.8-1.51.32.1-2.11.71.92.2
Fecal boli incidents, locomotor time 10.10.30.7-0.30.40.7-0.60.50.40.8
Change in fecal boli incidents, locomotor task0.20.20.3-0.40.30.6-0.50.50.60.3
Time >=10cm from walls, locomotor time 10.20.30.80.9-0.7-0.10.0-0.5-0.2-0.5
Bouts of movement, locomotor time 12.22.83.21.7-1.6-1.61.6-1.8-1.7-1.8
Total resting periods, locomotor time 12.63.03.31.7-1.6-1.71.7-1.8-1.8-1.8
Rest time, locomotor task time 10.50.80.90.9-0.9-0.70.9-0.9-1.0-0.7
Distance moved, locomotor task time 10.20.50.6-0.80.70.7-0.80.70.80.4
Vertical activity count, locomotor time 10.42.63.0-1.41.41.7-1.71.71.71.6
Time >=10cm from walls, locomotor time 20.00.10.40.6-0.50.10.1-0.2-0.3-0.1
Bouts of movement, locomotor time 20.10.30.60.5-0.5-0.60.7-0.5-0.7-0.2
Total resting periods, locomotor time 20.10.40.60.6-0.5-0.60.7-0.5-0.7-0.4
Rest time, locomotor task time 20.61.01.31.1-1.1-1.01.0-1.1-0.9-0.8
Distance moved, locomotor task time 20.20.20.5-0.70.70.3-0.30.50.30.1
Vertical activity count, locomotor time 20.51.21.5-1.11.21.1-1.11.11.00.9
Light reinforcement 10.21.01.4-0.90.91.1-1.21.01.10.8
Light reinforcement 20.00.10.1-0.40.40.3-0.20.30.20.4
Bone: marrow area0.10.30.50.3-0.4-0.60.5-0.5-0.5-0.7
Bone: maximum diameter0.20.50.90.9-0.9-0.60.6-0.8-0.5-0.3
Bone: maximum force0.71.42.31.5-1.5-1.01.0-1.3-0.9-0.9
Bone: maximum moment0.81.42.21.5-1.5-1.11.0-1.3-0.9-1.0
Mean time between licks in bursts0.00.00.00.10.1-0.20.1-0.1-0.10.0
Mean num. licks in bursts0.20.40.7-0.80.80.8-0.60.70.50.2
Cd content in liver0.00.00.0-0.0-0.10.1-0.10.00.10.1
Co content in liver0.20.30.50.7-0.7-0.40.4-0.6-0.4-0.1
Cu content in liver2.93.44.11.7-1.7-2.01.9-1.9-2.0-1.8
Fe content in liver1.11.32.4-1.51.60.9-1.01.21.00.4
K content in liver0.00.00.1-0.20.20.0-0.00.10.00.4
Mg content in liver0.20.30.30.6-0.6-0.50.5-0.6-0.6-0.3
Mn content in liver0.50.60.70.7-0.8-0.90.8-0.8-0.8-0.7
Na content in liver1.11.21.6-1.21.21.1-1.21.21.30.6
Rb content in liver0.10.10.10.3-0.3-0.20.2-0.2-0.3-0.3
Se content in liver2.02.43.01.4-1.3-1.71.7-1.6-1.7-1.4
Sr content in liver0.00.00.0-0.20.2-0.0-0.00.10.0-0.2
Zn content in liver0.30.40.7-0.60.70.6-0.40.60.40.8
Bone: minimum diameter0.10.30.50.4-0.4-0.70.6-0.6-0.5-0.3
Time in familiar zone, hab. session 10.10.10.10.3-0.3-0.20.3-0.3-0.3-0.1
Time in novel zone, hab. session 10.20.20.4-0.30.40.5-0.50.40.60.5
Total zone transitions, hab. session 10.10.10.40.2-0.1-0.30.3-0.2-0.3-0.6
Total locomotion distance, hab. session 10.00.10.20.2-0.2-0.30.1-0.2-0.1-0.4
Locomotion velocity, hab. session 10.50.71.40.7-0.7-1.00.7-0.8-0.8-1.2
Time in familiar zone, hab. session 20.30.30.60.2-0.2-0.70.7-0.4-0.7-0.8
Time in novel zone, hab. session 20.10.10.20.2-0.20.3-0.20.00.20.4
Total zone transitions, hab. session 20.00.00.1-0.20.30.1-0.00.20.00.1
Total locomotion distance, hab. session 20.30.40.50.7-0.6-0.70.5-0.7-0.5-0.6
Locomotion velocity, hab. session 20.30.40.40.7-0.6-0.70.5-0.6-0.5-0.7
Novel to familiar place preference ratio1.31.73.4-0.80.81.6-1.21.11.21.9
Novelty place preference2.33.05.5-1.21.22.1-1.71.61.72.4
Time in novel zone, NPP test2.53.15.7-1.21.22.1-1.71.61.72.4
Total zone transitions, NPP test0.00.10.10.1-0.0-0.30.3-0.1-0.3-0.4
Total locomotion distance, NPP test0.81.11.41.2-1.1-1.10.9-1.1-0.8-1.1
Locomotion velocity, NPP test0.91.31.61.3-1.3-1.20.9-1.1-0.9-1.2
Intraocular pressure0.71.12.21.4-1.5-0.80.8-1.1-0.8-0.7
Delta distance traveled before/after self-admin1.01.11.4-1.01.21.2-1.21.11.10.6
Delta ambulatory time before/after self-admin1.32.23.0-1.41.51.6-1.71.61.60.6
Parametrial fat weight6.014.117.5-4.24.23.5-3.53.93.53.4
Pavlov. Cond. lever latency0.00.00.20.1-0.1-0.0-0.1-0.00.1-0.5
Pavlov. Cond. magazine entry latency0.10.10.3-0.60.50.3-0.30.40.30.2
Pavlov. Cond. change in total contacts0.20.20.50.3-0.3-0.60.7-0.5-0.7-0.1
Pavlov. Cond. index score0.00.00.1-0.30.30.10.00.10.00.3
Pavlov. Cond. latency score0.10.10.2-0.30.40.2-0.00.20.10.5
Pavlov. Cond. lever contacts0.00.00.1-0.30.30.10.00.20.00.4
Pavlov. Cond. magazine entry number0.00.00.10.3-0.3-0.10.1-0.2-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.30.40.70.8-0.8-0.50.4-0.7-0.4-0.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.10.1-0.10.2-0.0-0.10.2
Pavlov. Cond. response bias0.10.10.2-0.50.40.2-0.20.30.20.3
Pavlov. Cond. lever latency0.40.61.3-1.21.10.5-0.30.80.20.6
Pavlov. Cond. magazine entry latency0.30.40.8-0.40.30.6-0.80.60.70.9
Pavlov. Cond. change in total contacts0.10.30.70.8-0.9-0.30.2-0.5-0.1-0.6
Pavlov. Cond. index score0.20.30.90.9-0.9-0.40.1-0.5-0.1-0.3
Pavlov. Cond. latency score0.30.41.11.0-1.1-0.40.2-0.6-0.2-0.4
Pavlov. Cond. lever contacts0.10.20.60.8-0.8-0.20.0-0.40.0-0.3
Pavlov. Cond. magazine entry number0.40.50.80.4-0.3-0.70.9-0.6-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.30.40.4-0.40.40.50.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.6-0.7-0.1-0.1-0.30.1-0.0
Pavlov. Cond. response bias0.10.10.20.4-0.5-0.1-0.2-0.20.3-0.1
Time in closed arm before self-admin2.23.84.4-1.91.92.1-2.02.02.01.9
Time in closed arm after self-admin0.50.61.3-0.30.20.9-0.70.61.01.1
Time in open arm before self-admin1.72.13.41.7-1.8-1.31.3-1.6-1.3-1.0
Time in open arm after self-admin0.30.41.00.3-0.2-0.70.5-0.5-0.8-1.0
Bone: periosteal estimation0.41.01.41.1-1.2-1.00.9-1.1-0.8-0.7
Bone: periosteal perimeter0.00.00.10.2-0.30.1-0.2-0.10.20.3
Bone: post-yield work0.00.00.1-0.20.20.1-0.00.10.10.3
Progressive ratio test 1 active lever presses0.91.52.40.8-0.8-1.51.3-1.2-1.3-1.5
Progressive ratio test 1 breakpoint1.01.82.80.9-0.8-1.61.4-1.3-1.4-1.7
Progressive ratio test 1 inactive lever presses2.05.26.12.1-2.0-2.42.3-2.3-2.4-2.5
Progressive ratio test 2 active lever presses2.43.54.41.6-1.5-2.02.1-1.8-1.9-1.9
Progressive ratio test 2 breakpoint2.93.74.61.6-1.6-2.12.2-1.9-2.0-2.0
Progressive ratio test 2 inactive lever presses0.51.72.11.3-1.3-1.31.4-1.3-1.4-1.0
Incentive Sensitization - Responses0.61.72.51.1-1.0-1.41.6-1.2-1.3-1.3
Incentive Sensitization - Breakpoint0.71.52.31.0-0.9-1.31.5-1.2-1.3-1.2
Sum of active levers in priming session hrs 5-60.90.91.7-1.31.30.8-0.71.00.70.4
Progressive ratio1.02.93.81.5-1.5-1.61.7-1.7-1.9-1.9
Food seeking constrained by brief footshock0.00.10.30.00.0-0.20.2-0.1-0.3-0.5
Seeking ratio, punishment vs. effort0.81.82.3-1.21.21.3-1.41.31.51.5
Retroperitoneal fat weight2.19.510.3-3.23.13.0-3.23.23.02.8
Reaction time number correct0.51.62.4-0.80.61.6-1.51.11.51.4
Reaction time mean minus median0.00.20.5-0.70.70.3-0.40.50.30.4
Reaction time mean minus median AUC0.31.82.5-1.61.61.1-1.31.41.21.1
Reaction time num false alarms1.52.63.92.0-2.0-1.41.4-1.7-1.4-1.4
Reaction time num false alarms AUC1.84.25.52.3-2.3-1.81.9-2.1-1.9-1.9
Reaction time trials correct on left0.51.62.4-0.80.61.6-1.51.11.51.4
Reaction time trials on left0.51.72.6-0.80.61.6-1.51.11.61.5
Reaction time mean0.71.51.8-1.31.31.1-1.21.21.11.2
Reaction time mean AUC0.51.21.5-1.21.21.0-1.11.11.01.1
Median of all reaction times0.91.41.6-1.31.21.1-1.21.21.11.2
Reaction time omissions1.72.73.1-1.61.51.8-1.71.71.71.6
Reaction time false alarm rate3.95.55.72.4-2.3-2.32.4-2.3-2.4-2.3
Reaction time premature initiation rate0.81.22.0-1.41.40.9-1.11.11.00.2
Reaction time premature initiations0.62.02.5-1.51.31.4-1.61.41.60.8
Std. dev. reaction times0.10.50.7-0.80.80.6-0.60.70.50.7
Reaction time trials completed0.51.72.6-0.80.61.6-1.51.11.61.5
Reaction time trials AUC0.51.62.5-0.80.51.6-1.51.11.61.4
Run reversals in cocaine runway, females0.00.00.10.1-0.0-0.30.2-0.2-0.2-0.2
Run reversals in cocaine runway, males0.30.31.3-0.40.30.5-0.40.40.41.1
Latency to leave start box in cocaine runway0.50.71.10.6-0.8-0.91.0-0.9-1.0-0.6
Latency to leave start box in cocaine runway, F0.00.10.10.2-0.2-0.20.3-0.3-0.30.0
Latency to leave start box in cocaine runway, M1.51.42.30.7-0.9-1.41.5-1.2-1.5-1.0
Std. dev. time between licks in bursts0.50.91.31.2-1.0-0.91.0-1.0-1.0-0.4
Total sessions with >9 infusions0.30.40.8-0.30.4-0.80.7-0.3-0.8-0.9
Short access day 1 total inactive lever presses0.10.20.6-0.60.80.2-0.10.3-0.1-0.2
Short access day 10 total inactive lever presses0.10.50.70.8-0.8-0.50.7-0.7-0.8-0.8
Short access day 1 total infusions0.61.22.70.1-0.1-1.31.2-0.8-1.3-1.6
Short access day 10 total infusions0.10.10.2-0.30.5-0.40.3-0.1-0.3-0.4
Short access total infusions0.81.12.20.3-0.2-1.41.2-0.8-1.2-1.5
Short access day 1 locomotion1.11.82.70.7-0.7-1.61.5-1.2-1.7-1.5
Short access day 10 total locomotion0.93.85.31.7-1.7-2.02.0-1.9-2.0-2.3
Short access total locomotion3.04.66.01.6-1.6-2.42.4-2.1-2.4-2.3
One hour access (0.3 mA shock)1.51.72.41.0-0.9-1.41.5-1.2-1.5-1.6
Compulsive drug intake0.20.30.9-0.90.90.1-0.00.5-0.3-0.2
One hour access (shock baseline)0.30.70.90.9-0.8-0.90.8-0.9-0.7-0.8
Social response proportion2.02.62.9-1.71.71.7-1.51.71.41.6
Social responses0.60.81.0-1.00.91.0-1.01.00.90.7
Social time0.30.50.9-1.00.90.5-0.60.80.40.6
Soleus weight2.16.37.7-2.72.82.4-2.32.52.42.4
Bone: stiffness0.20.40.6-0.80.80.5-0.60.60.60.3
Tibialis anterior weight0.72.43.8-1.91.91.3-1.41.61.31.1
Time to tail flick, vehicle, before self-admin0.10.10.6-0.30.40.0-0.10.10.2-0.7
Time to tail flick, vehicle, after self-admin0.71.42.3-1.00.91.4-1.31.21.51.0
Time to tail flick, test, before self-admin0.30.40.8-0.10.10.8-0.90.50.80.6
Time to tail flick, test, after self-admin0.50.50.90.7-0.8-0.60.5-0.8-0.6-1.0
Delta time to tail flick, vehicle, before/after SA0.40.50.8-0.20.10.9-0.80.50.90.9
Delta time to tail flick, test, before/after SA1.92.32.91.1-1.2-1.71.7-1.5-1.7-1.7
Tibia length0.00.00.10.3-0.2-0.00.0-0.1-0.10.3
Ambulatory time before self-admin0.10.30.50.5-0.7-0.60.7-0.6-0.60.1
Ambulatory time after self-admin1.01.61.9-1.21.21.3-1.41.31.41.0
Bone: tissue strength0.20.20.30.6-0.6-0.40.5-0.5-0.5-0.4
Total heroin consumption1.01.22.2-1.51.50.9-0.91.10.80.6
Bone: trabecular number2.54.76.0-2.42.52.1-2.22.32.21.4
Bone: trabecular spacing0.81.11.51.2-1.2-1.01.1-1.2-1.1-0.4
Bone: trabecular thickness0.30.40.7-0.60.60.6-0.80.70.90.1
Bone: trabecular tissue density0.30.61.20.9-0.9-0.70.4-0.7-0.4-1.1
Water consumed over 24 hours0.10.30.4-0.60.50.4-0.50.50.60.4
Number of responses in last shaping day1.21.62.90.9-0.9-1.31.3-1.0-1.7-1.5