Hub : Genes

Strada

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC mRNA stability Strada 0.06 0.04 3.0e-03 0.06 0.05 0.03 0.06 1.2e-03 3.1e-03 2.7e-02 1.4e-03
2 BLA mRNA stability Strada 0.09 0.04 2.5e-06 0.09 0.09 0.1 0.09 1.7e-05 1.6e-05 8.5e-06 1.5e-05
3 IL mRNA stability Strada 0.34 0.11 3.2e-07 0.32 0.22 0.28 0.09 1.4e-08 4.2e-06 2.3e-07 3.5e-03
4 BLA gene expression Strada 0.32 0.13 0.0e+00 0.28 0.31 0.33 0.32 5.5e-15 5.5e-17 5.6e-18 3.2e-17
5 Liver mRNA stability Strada 0.03 0.02 6.0e-03 0 0.01 0.01 0 3.5e-01 2.8e-02 3.9e-02 1.6e-01
6 NAcc gene expression Strada 0.18 0.06 0.0e+00 0.24 0.27 0.26 0.27 1.2e-36 6.9e-41 4.4e-40 2.1e-40
7 IC gene expression Strada 0.3 0.1 4.4e-16 0.32 0.3 0.32 0.33 4.0e-14 6.1e-13 2.8e-14 1.8e-14
8 NAcc mRNA stability Strada 0.07 0.03 0.0e+00 0.12 0.13 0.13 0.13 2.6e-18 2.0e-19 1.6e-18 1.1e-18
9 LHb mRNA stability Strada 0.15 0.09 6.8e-03 0.03 0.04 0 0.03 5.3e-02 4.2e-02 2.7e-01 6.0e-02
10 PL gene expression Strada 0.2 0.06 0.0e+00 0.29 0.31 0.32 0.31 7.3e-32 2.2e-34 5.1e-35 1.6e-34
11 PL isoform ratio NM_001415111.1 0.03 0.03 8.7e-03 0 0.01 0.01 0.01 9.9e-02 4.4e-02 7.0e-02 3.8e-02
12 pVTA mRNA stability Strada 0.04 0.02 3.6e-04 0.04 0.03 0.04 0.04 1.9e-04 8.6e-04 5.9e-04 5.8e-04
13 IL gene expression Strada 0.21 0.11 5.1e-04 0.14 0.1 0.09 0.15 3.1e-04 2.7e-03 4.6e-03 2.1e-04
14 PL mRNA stability Strada 0.2 0.08 0.0e+00 0.26 0.27 0.26 0.28 1.3e-28 1.3e-29 3.5e-28 1.3e-30
15 Brain mRNA stability Strada 0.24 0.08 0.0e+00 0.34 0.34 0.32 0.34 3.6e-32 3.1e-32 1.5e-30 7.4e-33
16 Adipose mRNA stability Strada 0.2 0.07 0.0e+00 0.25 0.27 0.27 0.27 5.0e-28 4.5e-30 2.5e-30 5.1e-30
17 pVTA gene expression Strada 0.13 0.06 1.4e-12 0.17 0.14 0.15 0.16 2.6e-13 1.3e-11 3.3e-12 6.4e-13
18 OFC mRNA stability Strada 0.59 0.13 1.6e-09 0.24 0.36 0.32 0.34 1.9e-06 2.7e-09 2.0e-08 7.2e-09
19 NAcc intron excision ratio chr10_91604053_91614708 0.01 0.01 8.4e-03 0 0 -0 0 1.1e-01 7.3e-02 9.9e-01 3.8e-01
20 Brain gene expression Strada 0.14 0.06 4.6e-15 0.16 0.15 0.15 0.15 9.7e-15 3.3e-14 1.6e-13 1.1e-13
21 Brain isoform ratio NM_001415111.1 0.07 0.05 7.4e-04 0.01 0.02 0.02 0.03 3.4e-02 3.1e-03 7.7e-03 1.5e-03
22 NAcc intron excision ratio chr10_91604053_91611075 0.03 0.02 3.3e-04 0.03 0.03 0.04 0.03 1.0e-05 3.8e-05 2.5e-06 1.0e-05
23 Adipose intron excision ratio chr10_91604053_91617313 0.04 0.02 1.5e-03 0.01 0.02 0.02 0.01 1.0e-02 6.1e-03 1.1e-03 1.6e-02
24 NAcc intron excision ratio chr10_91611103_91614708 0.02 0.01 7.6e-04 0.01 0.01 0.01 0.01 1.9e-02 3.9e-03 3.4e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bone: apparent density0.51.03.7-1.6-1.1-1.9-0.31.81.21.10.81.2-1.40.4-0.60.81.10.7-1.2-0.7-0.50.1-0.90.70.20.5-0.1
Area under the delay curve0.10.20.8-0.6-0.2-0.9-0.00.50.20.50.10.5-0.40.2-0.30.30.40.4-0.4-0.40.10.3-0.10.50.00.80.5
BMI with tail1.24.211.9-2.0-1.4-1.4-3.30.71.51.92.01.6-1.61.1-2.22.22.12.2-1.1-2.43.4-1.5-2.31.7-1.93.4-1.3
BMI without tail1.68.818.8-3.5-2.4-2.7-4.32.02.53.02.92.7-2.92.1-3.23.33.03.0-2.0-3.24.3-1.9-3.02.1-2.54.3-1.7
Body weight3.414.725.4-4.7-3.8-3.9-5.03.13.74.14.03.8-3.73.1-3.84.14.13.9-3.2-3.84.8-3.3-3.93.9-2.74.3-2.1
Weight adjusted by age0.20.61.31.11.00.71.0-1.0-1.0-0.8-0.8-0.80.8-0.70.8-0.8-0.9-0.70.60.8-0.40.50.8-0.10.6-0.70.3
Bone surface3.36.513.6-3.6-3.1-3.7-1.73.53.02.92.62.8-2.72.6-2.32.42.62.3-2.8-1.91.5-2.2-2.23.0-0.90.5-1.0
Bone volume2.65.211.9-3.2-2.7-3.5-1.53.22.62.62.32.6-2.62.1-2.12.22.52.1-2.5-1.81.1-1.6-2.12.5-0.70.9-1.1
Breakpoint value in progressive ratio session0.10.21.20.4-0.5-0.1-0.10.30.40.10.40.2-0.40.6-0.10.10.40.3-0.4-0.30.2-0.8-0.6-0.3-1.1-0.2-0.7
Number of licking bursts0.00.10.60.5-0.10.10.7-0.0-0.1-0.0-0.1-0.10.20.2-0.2-0.30.00.1-0.1-0.3-0.2-0.30.00.20.1-0.7-0.0
Context. condit. distance diff. score0.10.10.80.60.20.9-0.3-0.7-0.4-0.3-0.2-0.40.3-0.1-0.2-0.3-0.4-0.10.2-0.00.2-0.20.1-0.9-0.10.00.2
Locomotion velocity, session 10.70.82.5-1.6-1.1-1.0-1.01.31.10.90.81.0-1.20.8-0.91.00.80.5-0.8-0.60.4-0.5-0.40.70.00.6-0.1
Locomotion distance, session 10.10.10.8-0.9-0.1-0.3-0.40.50.10.2-0.10.3-0.40.0-0.10.3-0.1-0.1-0.00.1-0.00.50.4-0.10.50.20.4
Locomotion velocity, session 20.40.41.4-0.4-0.9-0.3-0.71.00.90.60.70.6-0.71.2-0.40.60.40.2-0.90.00.0-1.1-0.2-0.1-0.8-0.6-0.9
Locomotion distance, session 20.10.10.9-0.1-0.10.4-0.10.20.0-0.1-0.2-0.0-0.10.40.20.0-0.3-0.2-0.20.3-0.4-0.10.6-1.00.2-0.80.3
Locomotion velocity, session 30.40.41.10.70.30.30.4-0.5-0.6-0.7-0.6-0.60.5-0.60.7-0.8-0.5-0.50.61.1-0.70.50.7-1.01.0-0.70.7
Locomotion distance, session 30.10.10.90.1-0.3-0.20.20.20.0-0.0-0.1-0.10.20.10.4-0.20.0-0.0-0.20.6-0.4-0.20.20.10.6-1.00.4
Stereotopy head waving bouts, day 30.40.51.40.60.80.10.7-0.3-0.6-0.6-0.7-0.50.3-1.00.3-0.6-0.4-0.70.60.7-1.21.20.6-0.60.90.20.7
Stereotopy head waving duration, day 30.30.41.01.00.80.50.8-0.5-0.7-0.6-0.7-0.50.3-0.70.1-0.6-0.4-0.60.50.6-1.01.00.5-0.90.50.00.4
Locomotion velocity, session 70.50.51.10.90.70.30.4-0.6-0.6-0.8-0.7-0.70.5-0.90.6-0.7-0.7-0.70.81.1-0.80.80.8-0.70.9-0.20.9
Locomotion distance, session 70.10.10.50.50.30.1-0.1-0.1-0.3-0.1-0.2-0.0-0.00.10.20.1-0.4-0.20.10.70.30.30.4-0.4-0.20.0-0.2
Stereotopy head waving bouts, day 70.70.82.10.70.60.71.0-0.5-0.7-0.9-0.9-0.80.8-0.70.8-1.0-0.8-1.10.71.1-1.40.70.9-1.31.0-1.20.9
Stereotopy head waving duration, day 71.92.35.81.51.11.71.9-1.0-1.3-1.6-1.5-1.41.4-1.11.3-1.7-1.3-1.71.01.6-2.41.11.4-2.11.3-1.91.2
Locomotion velocity, session 80.40.52.0-0.4-0.90.6-0.60.20.70.60.80.4-0.30.9-0.80.50.80.6-0.8-0.90.6-1.4-0.70.6-0.40.1-0.1
Locomotion distance, session 80.10.21.30.2-0.30.7-0.70.10.10.10.00.1-0.30.5-0.40.1-0.00.3-0.5-0.2-0.1-0.5-0.1-1.1-0.5-0.1-0.3
Degree of sensitization distance0.20.21.0-0.3-0.00.1-0.60.20.20.40.30.5-0.50.6-0.60.70.10.2-0.3-0.30.9-0.1-0.30.0-0.91.0-0.6
Degree of sensitization stereotypy1.21.33.20.90.71.31.0-0.8-0.9-1.2-1.1-1.11.2-0.71.2-1.3-1.2-1.31.01.2-1.30.71.2-1.81.1-1.71.1
Conditioned locomotion0.80.93.2-0.3-0.6-0.6-1.20.80.70.90.81.0-1.10.9-0.80.90.81.0-1.0-0.40.7-0.6-1.1-0.2-1.81.2-1.7
Cocaine response after cond. corrected0.40.51.30.50.60.11.0-0.7-0.7-0.5-0.6-0.70.8-0.60.7-0.6-0.7-0.70.90.7-0.10.41.01.11.1-1.00.7
Cocaine response after cond. not corrected0.71.03.90.60.4-0.01.3-0.6-0.8-0.8-0.8-0.91.0-0.61.0-1.0-0.9-1.01.01.1-0.60.31.30.91.6-2.01.2
Cocaine response before conditioning0.20.21.40.2-0.3-0.20.50.20.0-0.4-0.2-0.30.3-0.10.4-0.6-0.3-0.30.00.4-1.00.00.4-0.60.8-1.20.7
Saline control response2.43.48.5-0.7-1.4-0.8-2.51.21.61.71.91.6-1.61.9-2.11.81.81.9-1.7-2.12.0-1.9-2.10.4-2.91.9-2.4
Bone: connectivity density1.11.85.3-1.9-1.6-2.2-0.72.31.61.61.31.7-1.81.2-1.11.21.41.2-1.7-1.10.1-0.6-1.21.0-0.30.5-0.4
Bone: cortical apparent density3.45.310.82.02.51.62.1-2.1-2.5-2.5-2.6-2.21.7-2.92.4-2.3-2.2-2.12.32.5-2.73.32.1-2.82.1-0.71.7
Bone: cortical area0.61.04.3-1.6-1.1-2.1-1.11.21.01.00.91.0-1.10.4-0.80.91.10.9-0.5-0.00.8-0.4-0.71.50.20.4-0.6
Bone: cortical porosity5.35.814.9-2.5-3.0-3.2-2.12.52.82.42.92.1-2.02.6-2.02.22.42.0-1.9-1.22.6-3.3-1.83.9-1.20.0-1.8
Bone: cortical porosity4.04.411.4-2.4-2.6-3.0-1.92.12.42.22.51.9-1.82.2-1.81.92.21.8-1.7-0.92.4-2.7-1.83.4-0.90.2-1.4
Bone: cortical thickness5.59.216.72.13.21.52.5-2.7-3.1-3.1-3.1-3.12.6-4.13.4-3.1-2.7-3.03.73.9-2.94.03.1-2.03.8-1.52.6
Bone: cortical thickness3.74.56.91.72.21.11.9-1.8-2.1-2.2-2.1-2.21.9-2.62.6-2.2-2.1-2.22.42.6-2.12.62.1-1.82.3-1.51.9
Bone: cortical tissue density3.25.110.42.02.51.62.0-2.0-2.4-2.5-2.5-2.11.7-2.92.3-2.2-2.2-2.12.32.5-2.73.22.1-2.82.0-0.71.6
Condit. Reinf. active minus inactive responses3.03.44.3-1.4-2.0-1.9-1.92.02.02.02.01.9-2.02.1-2.01.91.81.8-2.0-1.61.8-1.9-1.81.1-1.91.0-1.8
Condit. Reinf. active-inactive response ratio1.11.21.9-0.7-1.3-1.2-1.11.21.21.21.21.1-1.21.4-1.21.11.01.1-1.3-0.81.0-1.3-1.10.5-1.20.4-0.9
Condit. Reinf. active responses3.94.96.3-1.8-2.3-2.2-2.32.42.32.32.32.4-2.42.4-2.52.32.42.3-2.5-2.01.8-2.2-2.31.2-2.41.5-2.3
Condit. Reinf. inactive responses1.21.62.5-1.3-1.3-1.2-1.11.51.31.31.21.5-1.61.2-1.51.31.51.4-1.5-1.30.7-0.8-1.40.7-1.11.1-1.1
Incentive salience index mean2.33.04.6-1.7-2.1-1.9-1.82.12.01.81.91.9-1.81.9-1.61.71.81.7-2.0-1.31.2-1.8-1.81.1-1.60.7-1.4
Condit. Reinf. lever presses0.40.61.4-1.0-1.2-0.6-0.91.21.10.70.80.8-0.70.8-0.30.71.00.6-1.00.2-0.2-0.8-0.80.2-0.5-0.0-0.5
Condit. Reinf. active minus inactive responses4.57.012.4-2.7-3.2-3.2-2.33.52.92.92.63.0-3.03.3-2.52.72.62.5-3.2-2.51.8-2.6-2.51.4-2.00.9-2.0
Condit. Reinf. active-inactive response ratio2.33.66.8-1.9-2.3-2.4-1.42.62.22.12.02.1-2.02.3-1.91.82.01.7-2.3-2.01.1-2.0-1.71.4-1.30.5-1.3
Condit. Reinf. active responses6.79.714.2-2.9-3.5-3.5-3.13.83.33.43.13.4-3.53.7-3.03.23.03.1-3.6-3.02.5-2.9-3.01.7-2.81.8-2.7
Condit. Reinf. inactive responses2.33.45.6-1.4-1.7-1.9-2.21.91.71.91.72.0-2.22.0-1.82.01.72.0-1.9-1.51.7-1.3-1.90.4-2.41.8-2.3
Condit. Reinf. lever presses2.02.94.1-1.8-2.0-1.7-2.02.01.91.81.81.8-1.82.0-1.51.81.71.6-1.9-1.61.4-1.8-1.60.7-1.60.9-1.5
Condit. Reinf. lever reinforcers received6.18.512.6-2.8-3.3-3.4-2.93.53.13.22.93.2-3.33.4-2.83.02.92.9-3.3-2.92.3-2.7-2.81.7-2.61.8-2.6
Conditioned reinforcement - actives0.21.02.1-1.2-1.0-1.1-1.30.70.91.01.01.0-1.00.9-1.21.01.01.2-0.9-1.01.5-0.9-0.70.7-0.50.8-0.2
Conditioned reinforcement - inactives0.51.42.8-1.5-1.3-1.5-1.50.91.21.11.31.0-1.20.8-1.21.01.11.3-0.8-1.41.7-1.0-0.91.2-0.41.20.3
Conditioned locomotion2.84.26.7-2.5-2.2-2.6-2.12.02.22.22.32.1-2.21.9-2.22.12.12.3-2.0-2.22.5-1.9-1.81.7-1.01.3-0.6
Patch foraging indifference point 0 sec2.67.410.5-2.6-2.7-2.8-3.13.02.63.02.53.0-3.12.6-3.02.72.72.9-2.7-3.22.3-1.9-2.91.3-2.72.6-2.6
Patch foraging indifference point AUC0.41.01.6-1.3-1.1-0.8-1.20.91.01.01.01.1-1.00.9-0.81.10.91.2-1.1-1.20.9-1.0-1.10.5-0.81.0-0.5
Delay disc. indifference point, 0s delay0.30.41.10.80.80.31.0-0.3-0.7-0.5-0.7-0.40.4-0.60.5-0.7-0.4-0.30.30.6-1.00.90.3-0.50.10.10.8
Delay disc. indifference point, 16s delay0.50.81.7-0.9-0.5-1.3-0.60.80.61.00.81.0-0.90.7-0.90.90.90.9-0.9-1.11.0-0.4-0.61.1-0.71.3-0.5
Delay disc. indifference point, 2s delay0.40.51.8-1.1-0.7-1.1-0.01.30.60.80.31.0-0.90.6-0.60.50.80.7-1.0-0.4-0.60.1-0.50.50.30.50.6
Delay disc. indifference point, 24s delay1.22.04.1-1.9-1.1-1.5-1.41.31.31.51.41.5-1.51.2-1.51.61.41.4-1.3-1.61.6-0.8-1.21.2-0.92.0-0.5
Delay disc. indifference point, 4s delay0.60.71.40.70.70.10.9-0.6-0.8-0.6-0.8-0.80.9-0.71.0-0.9-0.8-0.80.81.0-0.80.81.20.11.2-1.01.1
Delay disc. indifference point, 8s delay0.10.10.9-0.20.2-0.50.40.2-0.20.0-0.30.1-0.2-0.40.20.0-0.2-0.10.20.0-0.50.90.1-0.00.30.80.7
Indifference point function ln k0.10.31.00.80.60.10.5-0.3-0.6-0.6-0.7-0.50.3-0.60.5-0.6-0.3-0.60.70.6-0.91.00.5-0.70.4-0.3-0.1
Indifference point function log k0.10.31.00.80.60.10.5-0.3-0.6-0.6-0.7-0.50.3-0.60.5-0.6-0.3-0.60.70.6-0.91.00.5-0.70.4-0.3-0.1
Patch foraging total patch changes 0 sec2.77.910.7-2.7-2.8-2.9-3.13.02.73.12.63.0-3.12.7-3.12.92.73.0-2.7-3.32.5-2.0-2.91.6-2.72.6-2.6
Patch foraging total patch changes 12 sec5.47.29.9-2.8-2.7-2.1-2.82.92.82.92.63.0-2.83.0-2.72.92.62.8-3.1-3.02.0-2.5-2.91.3-2.92.2-2.5
Patch foraging total patch changes 18 sec1.84.35.7-2.0-2.1-1.8-2.42.02.12.22.12.1-2.12.1-2.22.31.92.2-1.8-2.42.4-2.0-2.21.2-2.31.7-2.0
Patch foraging total patch changes 24 sec1.44.87.1-2.5-2.4-2.5-2.32.72.32.52.12.5-2.62.2-2.22.42.12.3-2.2-2.51.8-1.5-2.30.9-1.61.8-1.4
Patch foraging total patch changes 6 sec2.33.95.6-1.9-2.1-2.1-2.42.12.02.11.92.1-2.11.9-2.02.01.92.1-1.9-2.21.7-1.6-2.01.4-1.81.7-1.8
Patch foraging time to switch 0 sec0.20.61.50.90.90.91.0-0.8-0.6-0.8-0.6-0.81.0-0.50.9-0.7-0.6-1.00.71.2-0.50.30.90.20.3-0.9-0.2
Patch foraging water rate 0 sec0.93.35.1-2.2-1.8-2.1-2.21.81.82.01.81.9-2.11.4-1.82.01.72.0-1.5-2.21.9-1.0-1.91.2-1.32.3-0.8
Patch foraging water rate 12 sec0.41.64.50.81.10.51.2-1.2-1.3-1.2-1.3-1.31.3-1.41.2-1.3-1.2-1.31.51.3-0.61.41.4-0.42.1-1.01.9
Patch foraging water rate 18 sec0.10.31.5-0.1-0.0-0.40.70.4-0.2-0.1-0.4-0.1-0.1-0.10.2-0.3-0.3-0.30.10.2-0.80.60.3-0.91.1-0.61.2
Patch foraging water rate 24 sec0.10.10.70.10.00.00.6-0.1-0.3-0.1-0.3-0.20.30.10.1-0.3-0.3-0.20.10.3-0.10.10.4-0.10.8-0.80.7
Patch foraging water rate 6 sec0.10.20.9-0.4-0.2-0.90.30.40.00.1-0.10.1-0.4-0.3-0.2-0.00.10.30.2-0.4-0.10.7-0.0-0.10.80.20.8
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.10.20.5-0.5-0.4-0.10.00.2-0.10.1-0.0-0.20.3-0.1-0.00.1-0.10.7-0.2-0.50.1-0.40.60.5
Distance traveled before self-admin0.40.83.31.30.60.41.4-0.8-0.9-0.9-0.8-0.91.0-0.61.0-1.0-0.8-0.80.80.7-0.60.30.90.31.1-1.80.4
Distance traveled after self-admin0.10.21.50.7-0.10.10.7-0.3-0.3-0.3-0.3-0.40.60.30.4-0.6-0.6-0.20.10.4-0.1-0.60.4-0.10.1-1.20.3
Extensor digitorum longus weight0.93.612.42.63.03.51.0-3.4-2.4-1.8-1.6-2.02.1-2.50.9-1.5-1.3-1.32.30.90.01.70.80.0-0.11.80.7
Bone: elastic displacement2.22.85.51.01.51.11.7-1.5-1.5-1.7-1.6-1.71.7-2.02.1-1.8-1.6-1.91.81.9-1.61.71.8-0.92.3-1.32.0
Bone: elastic work0.30.41.7-0.60.1-0.60.3-0.1-0.1-0.3-0.1-0.30.1-1.00.9-0.3-0.1-0.40.71.0-0.30.70.40.61.30.11.0
Bone: endosteal estimation13.332.543.0-5.8-6.5-6.0-5.46.16.26.06.15.9-5.66.6-6.05.95.55.7-5.9-5.65.6-6.3-5.35.4-4.92.7-4.6
Bone: endosteal perimeter13.833.743.6-6.1-6.5-5.8-5.66.06.26.36.26.0-5.56.6-6.06.05.85.8-6.1-5.75.8-6.6-5.66.1-4.72.8-4.4
Epididymis fat weight0.31.52.8-1.3-0.9-1.0-1.40.91.01.21.21.2-1.21.0-1.51.51.21.2-0.9-1.31.6-0.8-1.11.2-1.11.7-1.0
Delta time in closed arm before/after self-admin0.40.31.00.10.30.10.6-0.3-0.4-0.6-0.5-0.50.5-0.50.7-0.6-0.7-0.60.60.8-0.70.50.7-0.01.0-0.70.8
Delta time in open arm before/after self-admin0.20.31.30.30.20.2-0.0-0.1-0.00.10.10.3-0.6-0.0-0.70.30.40.6-0.3-0.60.20.1-0.4-0.9-1.11.0-0.9
Diff in mean of infusions in LGA sessions1.12.04.11.71.62.01.0-1.7-1.5-1.6-1.4-1.51.3-1.51.5-1.5-1.3-1.51.51.1-1.31.31.3-1.70.4-0.31.1
Delay discount exponential model param0.20.30.90.80.31.00.2-0.7-0.4-0.6-0.3-0.60.5-0.30.4-0.5-0.5-0.50.50.5-0.2-0.10.2-0.70.0-0.8-0.4
Extinction: sum of active levers before priming0.10.21.30.3-0.1-0.1-0.30.10.10.20.20.3-0.40.3-0.80.10.30.5-0.5-0.30.2-0.3-0.5-0.6-1.20.6-0.9
Active lever presses in extinction session 61.91.93.1-0.9-1.3-1.3-1.81.21.41.41.51.3-1.31.3-1.61.31.41.3-1.2-1.61.5-1.4-1.61.2-1.51.0-1.6
Bone: final force0.30.43.0-1.2-0.8-1.7-0.30.90.60.50.40.5-0.50.3-0.10.30.40.4-0.30.20.2-0.1-0.11.20.9-0.40.3
Bone: final moment0.30.43.3-1.1-0.8-1.8-0.30.90.60.50.40.5-0.50.2-0.10.30.40.4-0.20.30.1-0.1-0.11.21.0-0.50.4
Food consumed during 24 hour testing period2.14.26.6-2.2-2.1-1.4-2.61.62.02.02.12.0-2.11.9-2.32.22.22.3-1.7-2.02.3-1.9-2.31.5-2.02.4-1.7
Glucose1.32.03.41.61.41.61.2-1.8-1.6-1.5-1.4-1.61.8-1.31.4-1.5-1.4-1.61.61.7-0.80.81.6-0.51.4-1.41.0
Heart weight0.20.41.7-0.20.6-0.20.4-0.7-0.7-0.4-0.6-0.50.6-0.80.6-0.5-0.5-0.50.90.80.30.80.50.21.3-0.10.9
Delay discount hyperbolic model param0.20.30.90.80.41.00.2-0.7-0.4-0.6-0.3-0.60.5-0.30.4-0.4-0.5-0.50.50.5-0.1-0.10.2-0.7-0.0-0.8-0.5
Intermittent access intake day 1-15 change0.00.11.00.2-0.00.4-0.5-0.5-0.0-0.00.2-0.20.5-0.0-0.0-0.1-0.00.10.30.10.6-0.6-0.11.0-0.1-0.30.0
Intermittent access intake escalation0.10.42.1-0.3-0.5-0.1-1.0-0.10.40.50.70.20.00.5-0.50.40.50.5-0.1-0.41.1-1.1-0.61.5-0.50.1-0.3
Intermittent access intake escalation 20.30.52.6-0.5-0.6-0.3-0.90.10.60.60.80.4-0.20.6-0.60.50.60.7-0.2-0.41.2-1.2-0.71.6-0.70.2-0.5
Intermitt. access day 1 inactive lever presses0.44.56.6-2.1-2.3-2.2-2.62.32.32.22.32.2-2.31.9-2.42.22.22.2-2.1-2.31.8-1.8-2.21.7-1.91.7-1.6
Intermitt. access day 15 inactive lever presses0.52.94.9-1.4-1.4-2.1-1.91.51.71.71.81.6-1.91.0-1.81.81.71.8-1.1-2.21.9-0.8-2.01.5-1.72.0-1.8
Intermitt. access escalation Index1.03.15.22.21.82.02.1-1.8-1.9-1.8-1.8-1.92.2-1.31.8-1.9-1.9-1.91.61.6-1.51.01.6-1.21.5-2.30.9
Intermittent access day 1 total infusions0.41.11.9-1.3-1.4-1.2-1.21.21.11.11.01.1-1.31.2-1.11.01.11.2-1.2-1.20.9-1.0-0.90.0-0.20.20.1
Intermittent access day 15 total infusions1.02.44.9-1.7-1.7-1.4-2.01.11.51.61.61.5-1.41.5-1.71.51.61.8-1.3-1.72.2-1.8-1.61.5-0.80.9-0.4
Intermittent access terminal intake (last 3 days)2.34.05.9-2.3-2.3-1.9-2.31.82.12.12.12.0-2.02.1-2.22.02.12.3-1.9-2.12.4-2.2-2.01.8-1.21.0-0.8
Intermittent access total infusions2.93.45.4-2.3-2.2-1.8-2.21.81.92.01.92.0-2.02.1-2.11.92.02.1-2.0-2.12.0-2.0-1.91.0-0.80.8-0.2
Intermittent access day 1 locomotion2.44.57.4-2.7-2.5-2.6-2.62.22.42.22.32.1-2.42.1-2.22.12.22.3-2.0-2.22.5-2.0-1.91.2-0.81.4-0.1
Intermittent access day 15 total locomotion1.76.611.2-3.3-3.0-2.2-3.12.42.82.72.82.6-2.52.8-2.82.62.62.8-2.6-2.92.9-2.7-2.71.6-1.51.7-0.3
Intermittent access total locomotion7.48.915.2-3.9-3.5-3.0-3.73.13.33.23.23.1-3.23.2-3.23.13.13.2-3.1-3.13.1-2.9-2.91.5-1.51.9-0.6
Intermittent access standard deviation0.20.92.0-1.4-1.2-0.9-1.30.81.10.81.10.9-1.00.7-1.00.91.01.1-0.7-0.91.1-0.9-1.00.8-0.30.80.2
Left kidney weight0.10.72.6-0.20.40.00.5-0.3-0.7-0.5-0.8-0.60.5-0.71.2-0.7-0.7-0.90.71.0-0.70.90.9-0.91.6-0.91.2
Right kidney weight0.10.53.7-0.9-0.1-0.40.30.1-0.3-0.2-0.5-0.30.2-0.50.7-0.3-0.4-0.60.40.8-0.50.60.5-0.21.9-0.71.7
Cocaine induced anxiety0.20.72.30.50.50.10.7-0.6-0.7-0.7-0.8-0.90.7-0.90.9-0.9-0.8-0.80.91.0-0.81.01.0-0.51.5-0.70.7
Post-drug Anxiety0.91.03.60.50.70.30.8-0.9-0.9-0.9-1.0-1.11.0-1.21.1-1.1-1.0-1.01.21.0-0.71.21.0-0.41.9-0.71.2
Baseline Anxiety0.10.10.40.10.40.40.2-0.6-0.4-0.4-0.3-0.40.4-0.60.3-0.3-0.4-0.40.60.20.10.40.1-0.10.40.20.5
Tail length1.79.416.1-4.0-3.4-3.7-3.53.63.53.33.33.3-3.53.0-2.93.33.22.9-3.1-2.62.7-2.5-2.72.5-1.92.2-1.7
Length with tail1.77.715.1-3.9-3.3-2.9-2.93.23.13.12.93.0-2.82.9-2.42.93.02.5-3.1-2.22.3-2.8-2.63.1-1.41.6-1.0
Length without tail0.10.52.4-1.2-0.8-0.4-0.60.60.70.70.70.7-0.50.6-0.40.70.80.5-0.7-0.20.3-0.8-0.51.60.20.40.2
Times rat made contact with spout0.70.81.9-1.4-1.1-0.7-0.60.91.00.91.00.9-0.80.9-0.81.00.80.8-0.8-0.80.9-1.1-0.80.9-0.40.4-0.2
Lifetime Intake3.24.05.6-2.4-2.3-1.9-2.42.02.12.12.12.1-2.22.1-2.22.02.22.3-2.1-2.32.1-2.0-2.11.0-1.11.1-0.6
Liver weight, left2.95.010.6-3.3-3.1-2.1-2.02.92.72.42.42.4-2.13.0-1.72.32.21.8-2.7-1.41.4-2.9-2.11.5-1.20.2-0.9
Liver weight, right1.01.74.50.21.00.40.8-0.7-1.1-1.0-1.3-1.21.0-1.41.6-1.1-1.4-1.51.51.7-1.31.71.6-1.22.1-0.91.9
Locomotor activity0.60.91.9-0.9-1.3-0.8-1.40.90.90.80.80.8-0.91.1-1.10.80.61.2-0.7-1.41.0-1.2-0.7-0.8-0.7-0.0-0.5
Locomotor testing distance0.81.94.1-1.2-1.7-1.5-2.01.21.41.21.41.2-1.41.6-1.61.31.01.6-0.9-1.62.0-1.7-1.0-0.1-1.40.6-1.4
Locomotor testing rearing0.62.15.1-0.9-1.6-1.0-2.30.91.51.11.61.1-1.11.7-1.71.30.91.6-0.8-1.62.3-2.0-1.10.1-1.90.6-1.8
Locomotion in novel chamber0.50.73.2-0.3-0.10.10.4-0.3-0.2-0.2-0.3-0.50.90.00.9-0.5-0.7-0.90.31.1-0.2-0.31.30.81.7-1.81.7
Locomotion in novel chamber post-restriction0.51.53.4-1.2-1.3-1.5-0.41.51.21.41.11.4-1.21.3-1.40.91.31.3-1.6-1.70.6-1.0-1.21.8-0.40.6-0.0
Fecal boli incidents, locomotor time 10.10.21.90.30.1-0.4-0.1-0.10.00.20.20.2-0.00.3-0.30.10.10.3-0.2-0.20.5-0.4-0.01.2-0.80.2-1.4
Change in fecal boli incidents, locomotor task0.10.10.6-0.30.5-0.00.4-0.3-0.3-0.1-0.2-0.10.1-0.70.30.2-0.1-0.20.40.70.10.70.00.20.30.80.3
Time >=10cm from walls, locomotor time 12.93.67.92.11.61.72.4-1.9-1.9-1.9-1.9-2.02.2-1.22.0-2.0-2.0-1.81.62.1-1.51.01.9-1.21.9-2.81.8
Bouts of movement, locomotor time 10.30.31.10.50.70.3-0.3-0.6-0.5-0.4-0.5-0.50.3-0.90.5-0.4-0.5-0.60.70.7-0.31.00.7-0.5-0.01.10.2
Total resting periods, locomotor time 10.30.41.20.40.80.3-0.2-0.6-0.6-0.5-0.5-0.50.4-1.00.5-0.4-0.6-0.70.80.7-0.41.10.8-0.30.21.00.4
Rest time, locomotor task time 10.10.10.40.40.40.10.5-0.0-0.2-0.3-0.3-0.1-0.0-0.60.2-0.1-0.2-0.30.30.3-0.60.60.30.0-0.30.2-0.5
Distance moved, locomotor task time 10.10.31.0-1.0-0.5-0.2-0.90.40.60.60.60.5-0.20.5-0.30.40.60.4-0.5-0.30.7-0.6-0.70.50.50.30.3
Vertical activity count, locomotor time 10.00.20.5-0.7-0.6-0.7-0.20.40.50.40.50.4-0.20.4-0.00.20.40.4-0.4-0.00.6-0.5-0.30.70.7-0.20.7
Time >=10cm from walls, locomotor time 20.20.53.00.70.20.21.0-0.6-0.4-0.7-0.4-0.80.8-0.50.7-0.7-0.6-0.50.80.8-0.30.00.50.21.1-1.70.7
Bouts of movement, locomotor time 20.10.31.01.00.90.4-0.0-0.7-0.7-0.4-0.4-0.50.5-0.60.5-0.4-0.3-0.50.60.5-0.10.70.3-0.1-0.40.7-0.8
Total resting periods, locomotor time 20.10.51.61.31.10.60.2-0.9-0.9-0.6-0.7-0.70.7-0.80.8-0.7-0.5-0.70.80.8-0.40.90.5-0.3-0.20.6-0.8
Rest time, locomotor task time 22.03.46.32.52.41.82.4-2.0-2.2-2.0-2.0-1.91.9-2.01.9-2.0-1.8-1.81.72.0-1.81.91.7-1.00.5-0.50.7
Distance moved, locomotor task time 20.30.31.4-1.2-0.9-0.1-1.00.60.90.50.80.4-0.30.5-0.30.50.60.4-0.5-0.30.5-0.7-0.50.20.5-0.20.5
Vertical activity count, locomotor time 20.92.23.6-1.8-1.8-1.6-1.81.71.91.41.81.5-1.71.4-1.41.51.61.5-1.4-1.41.4-1.5-1.30.8-0.80.7-0.9
Light reinforcement 10.21.04.2-0.3-0.4-0.9-1.00.90.50.70.51.0-1.50.1-0.90.80.91.1-0.8-1.40.10.6-1.6-0.9-1.42.0-1.3
Light reinforcement 20.40.82.9-0.7-0.4-1.4-0.61.20.60.70.51.1-1.50.0-0.80.80.81.0-0.8-1.0-0.10.6-1.2-0.1-0.91.7-0.7
Bone: marrow area12.731.241.2-5.7-6.4-5.9-5.36.06.15.95.95.8-5.46.4-5.95.85.45.6-5.7-5.45.6-6.2-5.25.3-4.82.6-4.5
Bone: maximum diameter3.67.212.0-3.0-3.1-3.5-2.33.12.93.02.82.9-2.72.8-2.72.82.82.6-2.7-2.32.3-2.7-2.43.4-1.61.0-1.9
Bone: maximum force0.81.55.1-2.1-1.3-2.2-1.11.51.11.41.11.3-1.31.0-1.01.31.21.0-0.9-0.31.2-0.6-0.72.00.20.5-0.4
Bone: maximum moment0.81.55.6-2.1-1.3-2.4-1.01.51.21.31.11.2-1.30.9-1.01.21.21.0-0.8-0.21.1-0.5-0.72.00.30.5-0.4
Mean time between licks in bursts0.00.31.8-0.7-0.3-0.8-0.5-0.00.20.40.40.3-0.20.2-0.40.40.40.5-0.2-0.61.1-0.4-0.11.40.10.5-0.0
Mean num. licks in bursts0.20.51.9-1.3-0.4-0.4-1.20.50.70.60.70.6-0.70.3-0.41.00.50.4-0.4-0.20.9-0.2-0.60.4-0.51.4-0.3
Cd content in liver2.73.06.32.32.12.51.5-2.2-1.9-1.9-1.8-1.91.8-1.61.6-1.7-1.9-1.81.61.9-1.51.41.5-1.30.8-0.71.3
Co content in liver1.21.44.51.41.32.11.4-1.5-1.2-1.3-1.1-1.31.3-1.00.9-1.2-1.0-1.10.90.6-1.40.50.8-1.30.8-0.81.1
Cu content in liver0.40.51.0-0.3-0.5-0.7-0.30.80.70.70.70.8-1.00.4-0.70.70.90.8-0.8-0.70.1-0.4-1.00.8-0.80.5-0.6
Fe content in liver0.20.32.50.4-0.20.20.30.30.1-0.2-0.1-0.10.20.40.6-0.4-0.3-0.4-0.41.0-0.7-0.40.3-0.60.2-1.60.1
K content in liver0.40.41.3-0.3-0.8-0.30.11.00.60.60.40.8-0.60.9-0.50.30.70.6-1.2-0.6-0.8-0.6-0.6-0.3-0.5-0.3-0.7
Mg content in liver0.50.54.30.90.61.01.1-0.1-0.5-0.5-0.7-0.30.3-0.40.4-0.6-0.2-0.3-0.20.2-2.10.80.0-1.6-0.1-0.3-0.0
Mn content in liver0.50.64.70.40.2-0.01.10.6-0.2-0.4-0.7-0.1-0.0-0.10.4-0.6-0.3-0.4-0.30.5-2.20.90.4-1.60.8-1.00.6
Na content in liver0.60.62.2-0.1-0.9-0.0-0.21.00.80.70.70.8-0.81.0-0.70.41.00.7-1.5-0.7-0.7-1.1-1.0-0.4-1.0-0.3-0.7
Rb content in liver4.45.19.62.42.22.52.7-1.8-2.2-2.2-2.4-2.12.2-1.82.5-2.4-2.2-2.31.72.1-3.11.92.0-2.61.9-2.51.9
Se content in liver1.01.12.81.31.11.51.3-0.9-1.2-1.0-1.2-0.90.9-0.90.9-0.9-1.0-1.10.51.0-1.61.00.7-1.70.6-0.90.5
Sr content in liver0.60.51.3-0.9-0.8-0.8-0.70.60.70.70.80.6-0.70.3-0.60.70.90.7-0.5-0.90.7-0.6-0.91.2-0.20.7-0.3
Zn content in liver0.50.51.00.60.80.71.0-0.6-0.8-0.6-0.8-0.70.7-0.60.9-0.6-0.7-0.80.70.9-0.90.70.7-0.50.7-0.80.8
Bone: minimum diameter12.123.329.1-5.3-5.3-5.4-5.05.05.15.25.15.0-4.84.9-5.25.05.14.9-4.8-4.34.8-4.9-4.64.9-3.43.0-3.7
Time in familiar zone, hab. session 10.91.02.3-0.8-0.8-0.1-0.90.60.91.11.01.0-0.71.2-1.11.10.90.9-1.1-1.11.3-1.3-1.11.0-1.50.8-1.1
Time in novel zone, hab. session 11.31.52.41.31.20.41.1-1.1-1.2-1.3-1.2-1.31.0-1.51.2-1.3-1.3-1.21.51.3-1.11.51.3-1.01.5-0.81.0
Total zone transitions, hab. session 10.10.10.8-0.9-0.4-0.1-0.90.20.30.20.20.3-0.40.3-0.40.40.30.3-0.1-0.10.6-0.20.0-0.20.20.10.4
Total locomotion distance, hab. session 10.50.62.8-1.7-0.9-1.2-1.21.10.90.70.70.8-1.00.5-0.60.80.70.6-0.5-0.30.6-0.1-0.40.30.40.50.5
Locomotion velocity, hab. session 10.81.13.8-2.0-1.3-1.4-1.51.41.21.11.01.1-1.30.8-0.91.11.00.9-0.9-0.70.8-0.5-0.70.50.20.70.4
Time in familiar zone, hab. session 21.21.43.7-0.9-1.2-0.2-1.30.81.21.11.21.0-0.81.7-1.41.20.91.1-1.3-1.41.4-1.9-1.00.5-1.60.4-1.1
Time in novel zone, hab. session 21.31.54.50.81.3-0.11.4-0.6-1.2-1.1-1.3-1.00.7-1.81.3-1.1-1.0-1.11.41.3-1.42.11.1-0.31.8-0.41.3
Total zone transitions, hab. session 20.10.10.7-0.5-0.30.5-0.80.10.20.10.10.2-0.30.4-0.50.10.20.2-0.3-0.40.1-0.30.0-0.8-0.1-0.00.1
Total locomotion distance, hab. session 20.50.61.7-1.2-0.6-0.4-1.30.90.80.70.50.9-1.20.5-1.20.80.80.7-0.9-1.00.20.0-0.5-0.5-0.41.1-0.1
Locomotion velocity, hab. session 20.40.51.6-1.3-0.5-0.3-1.20.90.70.70.40.8-1.00.4-1.00.70.70.6-0.8-0.80.10.1-0.4-0.5-0.31.10.0
Novel to familiar place preference ratio0.20.21.1-0.5-0.5-1.0-0.60.40.40.50.50.4-0.40.2-0.10.50.60.4-0.3-0.30.5-0.3-0.50.8-0.10.5-0.6
Novelty place preference0.10.10.5-0.2-0.3-0.7-0.40.20.20.20.20.2-0.10.00.10.20.30.2-0.1-0.10.2-0.1-0.20.50.00.3-0.4
Time in novel zone, NPP test0.00.00.4-0.2-0.2-0.7-0.20.10.10.10.10.00.0-0.00.30.10.20.00.10.10.1-0.1-0.00.30.20.0-0.2
Total zone transitions, NPP test0.10.21.3-0.8-0.20.2-0.50.40.10.1-0.20.3-0.40.2-0.50.10.10.0-0.3-0.1-0.40.40.2-1.10.6-0.00.7
Total locomotion distance, NPP test0.50.72.6-1.6-0.9-0.9-1.21.30.90.80.60.9-1.20.6-1.10.80.60.6-0.8-0.80.30.0-0.3-0.20.30.60.6
Locomotion velocity, NPP test0.40.62.0-1.4-0.6-0.7-1.31.00.70.80.50.9-1.10.4-1.20.80.70.7-0.7-0.90.40.2-0.4-0.20.01.10.2
Intraocular pressure1.01.66.6-0.9-0.7-1.4-1.80.40.71.11.11.0-1.20.6-1.31.41.11.2-0.2-1.42.6-0.5-0.91.6-1.12.1-1.4
Delta distance traveled before/after self-admin0.10.11.40.10.00.3-0.1-0.2-0.1-0.2-0.1-0.10.20.20.2-0.3-0.3-0.1-0.00.2-0.0-0.2-0.2-1.2-0.50.30.2
Delta ambulatory time before/after self-admin0.10.10.5-0.4-0.3-0.2-0.50.30.30.30.30.3-0.30.5-0.20.10.10.4-0.5-0.00.2-0.4-0.5-0.6-0.70.6-0.2
Parametrial fat weight0.20.41.7-1.2-0.7-1.30.10.90.60.50.40.5-0.7-0.1-0.30.50.60.4-0.40.0-0.30.1-0.31.30.60.30.7
Pavlov. Cond. lever latency1.31.63.21.81.81.41.6-1.7-1.6-1.2-1.5-1.31.3-1.41.0-1.2-1.5-1.11.40.4-0.61.51.1-0.50.5-0.30.6
Pavlov. Cond. magazine entry latency3.34.26.7-2.4-2.5-2.1-2.12.62.52.12.32.2-2.32.1-1.92.12.41.9-2.4-1.61.0-2.0-2.21.3-1.61.1-1.6
Pavlov. Cond. change in total contacts2.62.84.4-1.6-2.0-1.7-2.02.02.01.71.91.8-1.91.7-1.51.72.11.6-1.9-0.90.8-1.7-1.70.6-1.40.9-1.6
Pavlov. Cond. index score2.73.45.5-2.2-2.3-1.8-2.02.32.21.92.12.0-2.02.0-1.51.92.21.7-2.3-1.10.9-2.0-1.91.0-1.30.8-1.4
Pavlov. Cond. latency score2.22.74.5-2.0-2.1-1.5-1.92.12.01.71.91.8-1.71.9-1.41.72.01.5-2.1-1.00.8-1.9-1.70.8-1.10.6-1.1
Pavlov. Cond. lever contacts1.72.03.8-1.9-2.0-1.5-1.71.81.91.41.71.5-1.51.5-1.11.41.71.3-1.6-0.50.8-1.7-1.30.9-0.80.4-0.9
Pavlov. Cond. magazine entry number2.53.25.41.92.11.91.8-2.3-2.1-1.8-1.9-2.02.1-1.91.6-1.8-2.1-1.72.21.2-0.61.71.9-0.81.5-0.91.6
Pavlov. Cond. intertrial magazine entries1.72.03.9-0.6-0.9-1.1-1.41.11.01.51.21.5-1.71.4-2.01.61.31.7-1.4-1.81.7-0.9-1.30.4-1.81.6-1.8
Pavlov. Cond. lever-magazine prob. diff.2.63.25.4-2.1-2.2-1.9-1.92.32.21.92.02.0-2.01.9-1.51.92.21.6-2.2-1.10.9-1.9-1.81.1-1.20.8-1.4
Pavlov. Cond. response bias3.54.48.6-2.7-2.7-2.6-2.12.92.62.22.32.4-2.42.1-1.72.12.41.9-2.5-1.20.8-1.9-2.01.3-1.20.9-1.4
Pavlov. Cond. lever latency0.40.51.10.81.00.70.6-0.9-0.8-0.8-0.7-0.80.7-1.00.6-0.7-0.6-0.70.90.8-0.50.90.7-0.20.6-0.00.7
Pavlov. Cond. magazine entry latency2.33.35.32.01.62.02.1-1.9-1.9-1.8-1.8-1.92.2-1.51.9-1.9-1.8-1.71.62.2-1.61.01.8-1.41.6-2.31.3
Pavlov. Cond. change in total contacts0.40.92.4-0.5-1.1-0.2-0.81.00.91.00.90.9-0.81.6-0.90.90.80.9-1.4-0.90.4-1.4-0.9-0.2-1.3-0.1-1.1
Pavlov. Cond. index score0.10.11.00.1-0.30.30.20.00.0-0.0-0.0-0.10.30.40.1-0.1-0.1-0.1-0.20.2-0.1-0.60.2-0.4-0.0-1.0-0.2
Pavlov. Cond. latency score0.10.21.90.3-0.10.40.5-0.2-0.2-0.3-0.3-0.30.50.20.5-0.3-0.3-0.30.10.5-0.3-0.40.5-0.50.3-1.40.0
Pavlov. Cond. lever contacts0.30.40.8-0.6-0.8-0.5-0.50.80.70.70.60.7-0.60.9-0.50.70.60.6-0.8-0.70.4-0.7-0.60.0-0.70.2-0.6
Pavlov. Cond. magazine entry number3.54.67.4-2.1-1.8-2.2-2.42.12.22.22.22.3-2.41.7-2.22.32.32.1-2.0-2.42.0-1.3-2.31.8-2.12.7-1.9
Pavlov. Cond. intertrial magazine entries8.919.322.6-4.5-4.2-4.4-4.54.44.54.64.64.7-4.83.9-4.44.74.74.5-4.2-4.64.2-3.4-4.74.1-4.04.7-3.8
Pavlov. Cond. lever-magazine prob. diff.0.10.11.20.3-0.20.30.4-0.1-0.2-0.2-0.2-0.20.40.20.3-0.3-0.3-0.2-0.00.3-0.3-0.40.3-0.50.1-1.1-0.0
Pavlov. Cond. response bias0.00.10.2-0.1-0.30.10.10.30.10.20.00.1-0.00.5-0.10.10.10.1-0.40.0-0.1-0.4-0.1-0.3-0.1-0.5-0.1
Time in closed arm before self-admin0.10.10.40.10.00.5-0.0-0.3-0.1-0.4-0.1-0.40.2-0.20.3-0.4-0.3-0.40.40.1-0.0-0.0-0.3-0.60.4-0.30.4
Time in closed arm after self-admin1.01.23.10.50.61.21.1-1.0-0.8-1.2-0.9-1.21.2-0.91.2-1.2-1.2-1.31.01.1-0.90.40.8-0.41.5-1.31.8
Time in open arm before self-admin1.41.73.71.11.00.81.2-1.3-1.2-1.1-1.2-1.41.7-1.11.4-1.4-1.4-1.41.41.2-0.80.81.60.21.9-1.71.6
Time in open arm after self-admin0.30.30.9-0.1-0.2-0.3-0.50.10.20.60.40.5-0.40.4-0.80.60.60.6-0.4-0.70.8-0.4-0.20.5-0.80.7-0.9
Bone: periosteal estimation7.517.727.7-4.7-4.9-5.3-4.14.84.64.54.54.4-4.34.4-4.44.34.34.2-4.2-3.63.9-4.2-3.84.4-2.92.0-3.3
Bone: periosteal perimeter3.46.712.4-3.1-3.2-3.4-2.42.92.82.92.82.6-2.42.7-2.42.52.72.5-2.6-2.02.4-3.0-2.43.5-1.10.7-1.3
Bone: post-yield work1.12.04.5-1.7-1.6-1.7-1.51.31.41.41.51.3-1.11.7-1.51.41.21.2-1.1-0.71.9-1.7-1.02.1-0.80.4-1.1
Progressive ratio test 1 active lever presses2.13.76.1-2.1-2.1-2.5-2.32.01.92.01.92.0-2.31.8-2.31.92.02.2-1.8-2.12.0-1.5-1.81.1-1.11.5-0.9
Progressive ratio test 1 breakpoint2.54.36.6-2.3-2.2-2.6-2.52.22.12.12.12.2-2.41.9-2.42.12.22.4-2.0-2.22.1-1.6-2.01.2-1.41.7-1.0
Progressive ratio test 1 inactive lever presses1.84.76.5-2.2-2.4-2.4-2.52.32.22.32.22.3-2.42.2-2.52.22.32.4-2.2-2.52.2-2.0-2.01.3-1.61.4-1.3
Progressive ratio test 2 active lever presses5.07.110.9-2.9-2.9-3.3-2.92.72.72.92.72.8-2.92.5-2.92.72.83.0-2.6-2.82.8-2.3-2.62.3-1.71.9-1.4
Progressive ratio test 2 breakpoint6.07.711.2-3.0-3.0-3.4-3.02.82.83.02.82.9-3.02.7-3.02.82.93.1-2.6-2.93.0-2.5-2.72.5-1.81.9-1.5
Progressive ratio test 2 inactive lever presses1.44.56.8-2.5-2.1-2.3-2.62.12.12.32.12.3-2.41.8-2.52.22.32.4-1.9-2.62.2-1.4-2.31.4-1.42.2-1.0
Incentive Sensitization - Responses1.64.35.9-2.1-2.3-2.3-2.22.12.12.42.22.2-2.02.2-2.02.12.12.2-2.1-2.02.2-2.2-2.12.3-1.41.2-1.2
Incentive Sensitization - Breakpoint1.94.25.7-2.2-2.3-2.2-2.22.02.12.42.12.1-1.92.2-2.02.12.12.2-2.0-2.02.3-2.2-2.12.3-1.31.1-1.2
Sum of active levers in priming session hrs 5-60.50.42.41.60.81.00.4-0.9-0.7-0.7-0.5-0.60.5-0.40.2-0.7-0.4-0.30.40.2-0.30.20.4-1.0-0.9-0.2-0.6
Progressive ratio0.00.10.4-0.2-0.2-0.10.30.30.10.20.10.3-0.10.3-0.30.00.30.2-0.6-0.4-0.1-0.3-0.30.5-0.30.3-0.3
Food seeking constrained by brief footshock3.24.07.3-2.0-2.3-1.2-2.31.82.21.92.21.9-1.62.3-2.21.92.02.0-2.1-2.21.9-2.7-2.11.8-2.21.1-1.7
Seeking ratio, punishment vs. effort0.81.84.0-1.3-1.4-1.0-2.01.21.51.31.51.3-1.21.5-1.41.51.21.3-1.1-1.41.5-1.6-1.21.0-1.30.5-1.2
Retroperitoneal fat weight0.52.14.7-2.2-1.4-1.5-1.81.41.51.41.41.5-1.60.9-1.61.61.41.3-1.1-1.41.4-0.7-1.51.3-0.92.0-0.5
Reaction time number correct0.20.71.80.40.70.30.6-0.7-1.0-0.7-1.0-0.70.7-0.90.6-0.8-0.9-0.70.90.7-0.51.10.8-0.51.3-0.41.3
Reaction time mean minus median0.00.30.60.60.80.60.5-0.7-0.5-0.5-0.4-0.60.6-0.60.4-0.5-0.6-0.60.60.5-0.20.60.6-0.10.3-0.10.3
Reaction time mean minus median AUC0.31.72.41.31.61.41.5-1.2-1.4-1.3-1.4-1.31.3-1.21.1-1.4-1.3-1.41.11.3-1.41.41.4-1.21.2-1.01.1
Reaction time num false alarms2.44.16.3-2.4-2.5-1.9-1.72.22.22.12.12.1-2.02.2-2.01.92.22.2-2.1-2.51.9-2.3-2.31.5-1.40.8-1.1
Reaction time num false alarms AUC2.04.67.0-2.5-2.6-2.1-1.82.42.32.32.22.3-2.22.3-2.12.02.42.3-2.3-2.51.7-2.3-2.51.6-1.41.0-1.1
Reaction time trials correct on left0.20.71.80.40.70.30.6-0.7-1.0-0.7-1.0-0.70.7-0.90.6-0.8-0.9-0.70.90.7-0.51.10.8-0.51.3-0.41.3
Reaction time trials on left0.20.61.80.40.70.30.6-0.6-1.0-0.7-1.0-0.70.7-0.90.6-0.8-0.9-0.70.90.6-0.51.10.8-0.41.3-0.31.3
Reaction time mean0.61.32.61.31.20.91.6-0.8-1.0-1.1-1.2-1.11.1-0.90.9-1.3-1.3-1.20.91.2-1.41.11.4-1.10.8-1.40.5
Reaction time mean AUC0.71.83.11.71.51.31.8-1.0-1.2-1.4-1.3-1.31.3-1.11.1-1.5-1.4-1.41.11.3-1.51.21.6-1.30.8-1.50.5
Median of all reaction times0.91.42.91.41.20.91.7-0.7-1.1-1.2-1.2-1.11.1-0.91.0-1.3-1.3-1.30.91.2-1.51.11.4-1.20.9-1.50.5
Reaction time omissions0.10.20.9-0.60.0-0.9-0.20.60.30.50.30.5-0.6-0.1-0.20.40.20.2-0.2-0.40.30.60.00.7-0.00.9-0.3
Reaction time false alarm rate3.24.56.4-2.3-2.5-1.8-1.82.32.42.22.42.2-2.12.3-2.02.02.42.2-2.3-2.41.7-2.5-2.31.7-1.80.9-1.6
Reaction time premature initiation rate1.01.53.3-1.0-1.0-1.6-1.61.01.11.21.21.2-1.50.6-1.41.31.21.5-0.9-1.51.3-0.6-1.50.6-1.41.8-1.0
Reaction time premature initiations0.30.82.4-0.8-0.7-1.2-1.10.70.60.80.60.8-1.10.3-1.10.80.71.1-0.5-1.20.9-0.1-1.10.3-0.71.6-0.2
Std. dev. reaction times0.20.51.00.81.00.81.0-0.6-0.7-0.7-0.7-0.70.8-0.70.7-0.8-0.8-0.80.60.8-0.90.90.9-0.30.5-0.50.4
Reaction time trials completed0.20.61.80.40.70.30.6-0.6-1.0-0.7-1.0-0.70.7-0.90.6-0.8-0.9-0.70.90.6-0.51.10.8-0.41.3-0.31.3
Reaction time trials AUC0.20.61.90.40.70.30.6-0.7-1.0-0.7-1.0-0.70.7-0.90.6-0.8-0.9-0.70.90.7-0.51.10.7-0.51.3-0.31.4
Run reversals in cocaine runway, females0.40.51.50.10.90.10.1-0.9-0.5-0.4-0.3-0.60.6-1.20.5-0.4-0.3-0.51.20.30.41.00.60.90.90.70.9
Run reversals in cocaine runway, males0.20.20.80.40.4-0.10.3-0.5-0.4-0.3-0.2-0.40.5-0.50.5-0.3-0.4-0.40.50.50.10.20.20.90.7-0.50.3
Latency to leave start box in cocaine runway0.20.30.70.70.50.30.5-0.6-0.6-0.6-0.5-0.60.5-0.50.6-0.6-0.6-0.50.70.4-0.30.40.3-0.10.7-0.90.8
Latency to leave start box in cocaine runway, F0.70.81.41.00.90.40.5-1.0-0.9-0.9-0.8-1.01.0-0.81.1-1.0-0.9-1.01.11.1-0.30.61.10.21.2-1.10.8
Latency to leave start box in cocaine runway, M0.20.10.7-0.0-0.3-0.00.10.40.30.20.30.4-0.40.3-0.40.20.20.6-0.4-0.7-0.1-0.2-0.9-0.5-0.4-0.30.2
Std. dev. time between licks in bursts0.00.10.3-0.00.1-0.1-0.4-0.2-0.00.10.10.0-0.1-0.1-0.30.10.20.1-0.0-0.10.30.10.10.3-0.20.6-0.5
Total sessions with >9 infusions0.30.31.2-0.7-0.5-0.6-1.00.20.40.40.50.5-0.70.3-0.60.50.60.7-0.2-0.81.1-0.3-0.5-0.2-0.10.60.1
Short access day 1 total inactive lever presses1.22.34.3-2.1-1.7-1.7-2.01.61.61.61.61.5-1.61.3-1.51.61.61.5-1.1-1.71.8-1.2-1.51.4-0.41.3-0.1
Short access day 10 total inactive lever presses0.10.41.6-0.3-0.1-0.7-0.80.40.40.50.50.5-0.7-0.1-0.90.60.60.7-0.2-0.90.60.3-0.80.7-0.61.3-1.0
Short access day 1 total infusions0.30.51.2-0.7-0.6-0.7-0.90.70.60.70.70.8-1.00.7-0.80.70.90.9-0.6-1.10.9-0.4-0.8-0.5-0.50.6-0.4
Short access day 10 total infusions2.23.75.5-2.1-2.0-1.9-2.31.82.01.92.02.0-2.11.9-2.22.02.12.2-1.8-2.42.2-1.8-2.01.0-1.31.2-1.1
Short access total infusions1.31.93.0-1.4-1.4-1.4-1.61.41.41.41.41.4-1.61.4-1.51.41.51.6-1.3-1.71.5-1.2-1.40.3-0.90.8-0.9
Short access day 1 locomotion1.62.65.8-1.8-1.3-2.1-2.01.31.41.61.71.6-1.91.1-1.81.71.81.8-1.2-1.72.4-1.0-1.41.0-1.01.9-0.7
Short access day 10 total locomotion1.97.912.7-3.3-3.0-2.6-3.62.73.12.83.12.8-2.92.7-3.12.92.92.9-2.7-3.13.0-2.7-2.81.7-2.12.5-1.3
Short access total locomotion2.53.76.7-2.4-1.9-2.1-2.61.72.01.92.11.9-2.11.7-2.12.02.12.1-1.6-2.12.6-1.7-1.81.2-1.11.8-0.6
One hour access (0.3 mA shock)1.21.42.3-1.0-1.3-1.2-1.21.01.11.31.31.2-1.11.3-1.11.21.21.3-1.1-1.11.4-1.5-1.01.5-1.10.3-1.0
Compulsive drug intake0.81.12.01.00.90.81.1-0.9-1.1-1.0-1.1-1.21.3-1.01.4-1.1-1.2-1.31.11.0-1.10.81.2-0.11.1-1.00.4
One hour access (shock baseline)0.92.33.2-1.5-1.6-1.4-1.71.41.61.61.61.6-1.71.6-1.71.61.71.8-1.6-1.51.7-1.6-1.61.1-1.20.8-0.6
Social response proportion0.20.30.90.20.50.40.3-0.9-0.6-0.5-0.4-0.60.8-0.50.6-0.3-0.5-0.50.80.60.50.10.50.70.6-0.20.8
Social responses0.10.10.5-0.1-0.4-0.1-0.50.00.20.20.30.2-0.10.5-0.30.40.20.4-0.1-0.20.7-0.6-0.30.1-0.2-0.1-0.1
Social time0.10.22.00.0-0.1-0.50.1-0.30.10.10.4-0.00.20.2-0.20.20.00.10.2-0.11.2-0.60.21.40.0-0.2-0.3
Soleus weight0.10.31.4-0.6-0.5-0.3-0.60.30.40.60.60.4-0.20.5-0.20.50.60.4-0.3-0.30.7-0.8-0.71.2-0.20.10.1
Bone: stiffness0.30.51.5-1.2-0.9-0.8-0.51.00.60.80.50.8-0.71.2-0.80.70.60.6-0.90.00.5-0.8-0.40.5-0.0-0.5-0.2
Tibialis anterior weight0.31.06.4-0.00.10.8-1.3-0.50.40.60.90.5-0.50.1-1.00.81.10.9-0.4-0.71.3-0.7-1.41.3-1.52.5-0.9
Time to tail flick, vehicle, before self-admin0.50.63.60.30.2-0.11.2-0.0-0.4-0.3-0.5-0.40.6-0.30.8-0.6-0.5-0.60.30.7-0.80.31.30.91.6-1.90.8
Time to tail flick, vehicle, after self-admin0.00.10.2-0.0-0.1-0.30.40.40.00.3-0.10.3-0.40.0-0.30.30.20.1-0.3-0.4-0.30.2-0.10.40.10.0-0.4
Time to tail flick, test, before self-admin0.20.20.90.60.20.90.3-0.5-0.2-0.5-0.2-0.50.7-0.20.5-0.3-0.4-0.60.40.5-0.1-0.20.2-0.1-0.3-0.4-0.3
Time to tail flick, test, after self-admin0.00.00.20.1-0.00.3-0.10.20.00.2-0.00.1-0.0-0.0-0.3-0.10.2-0.1-0.2-0.1-0.40.0-0.3-0.3-0.2-0.1-0.4
Delta time to tail flick, vehicle, before/after SA1.41.53.8-1.0-0.9-0.7-1.11.11.21.11.11.3-1.40.8-1.51.31.31.2-1.1-1.40.9-0.7-1.70.5-1.81.9-1.3
Delta time to tail flick, test, before/after SA0.10.10.6-0.1-0.10.10.20.40.00.2-0.20.2-0.20.1-0.3-0.20.10.1-0.4-0.1-0.80.2-0.2-0.50.3-0.40.2
Tibia length0.20.53.6-0.9-0.0-0.30.60.1-0.3-0.3-0.5-0.30.4-0.30.9-0.3-0.5-0.50.40.7-0.60.60.4-0.31.8-1.11.9
Ambulatory time before self-admin0.10.42.30.90.20.21.0-0.5-0.6-0.6-0.5-0.60.7-0.30.8-0.7-0.6-0.50.50.5-0.4-0.00.60.40.8-1.50.5
Ambulatory time after self-admin0.00.10.30.3-0.1-0.10.4-0.0-0.1-0.1-0.0-0.10.20.30.3-0.3-0.2-0.0-0.00.20.1-0.4-0.00.0-0.1-0.6-0.1
Bone: tissue strength1.61.73.80.71.11.01.3-1.0-1.3-1.2-1.4-1.21.2-0.91.3-1.2-1.4-1.41.22.0-1.11.11.7-1.01.6-1.51.4
Total heroin consumption0.40.51.4-0.2-1.1-0.6-0.21.00.80.50.60.6-0.71.2-0.30.40.50.4-1.0-0.70.1-1.2-0.2-0.3-0.5-1.1-0.5
Bone: trabecular number1.22.26.4-2.1-1.7-2.5-0.72.51.71.71.31.8-2.01.3-1.21.31.61.3-1.8-1.20.1-0.6-1.21.0-0.30.5-0.6
Bone: trabecular spacing0.30.42.31.00.51.5-0.1-1.3-0.7-0.7-0.4-0.70.9-0.20.0-0.5-0.6-0.30.60.10.3-0.30.4-0.6-0.3-0.4-0.2
Bone: trabecular thickness1.72.39.1-2.1-1.5-3.0-1.02.11.61.71.51.7-1.80.6-0.91.41.71.4-1.2-1.10.8-0.3-1.42.2-0.21.5-0.8
Bone: trabecular tissue density1.11.94.60.31.40.41.2-0.8-1.4-1.2-1.6-1.10.9-1.51.4-1.1-1.4-1.51.51.8-1.32.11.7-0.92.2-0.81.6
Water consumed over 24 hours0.00.10.5-0.7-0.3-0.10.00.20.30.20.20.2-0.30.00.00.30.20.10.00.20.10.0-0.20.10.30.30.6
Number of responses in last shaping day0.10.10.7-0.3-0.3-0.8-0.40.20.30.30.40.2-0.30.0-0.30.30.40.30.1-0.50.7-0.10.10.90.20.2-0.2