Hub : Genes

Stk11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Stk11 0.05 0.04 7.1e-05 0.03 0.03 0.03 0.03 9.5e-05 1.7e-04 3.1e-04 1.7e-04
2 Adipose mRNA stability Stk11 0.07 0.05 1.2e-06 0.05 0.05 0.05 0.05 2.2e-06 2.8e-06 2.3e-06 2.0e-06
3 Liver mRNA stability Stk11 0.06 0.05 5.2e-06 0.05 0.03 0.03 0.03 6.9e-06 3.8e-04 1.5e-04 1.1e-04
4 Liver gene expression Stk11 0.07 0.05 6.4e-05 0.04 0.03 0.03 0.03 4.1e-05 2.0e-04 1.4e-04 2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.42.36.10.9-1.11.12.5
Area under the delay curve1.41.52.8-1.71.3-1.2-0.1
BMI with tail5.517.723.4-4.74.8-4.8-1.3
BMI without tail3.36.99.1-2.73.0-2.7-2.1
Body weight1.04.36.0-2.32.4-2.3-0.8
Weight adjusted by age1.41.52.2-1.31.2-0.9-1.5
Bone surface3.46.012.21.9-2.02.13.5
Bone volume3.45.811.71.7-2.02.13.4
Breakpoint value in progressive ratio session2.83.14.32.1-1.92.0-0.8
Number of licking bursts0.70.81.7-0.80.6-0.6-1.3
Context. condit. distance diff. score0.30.30.6-0.30.8-0.6-0.5
Locomotion velocity, session 11.61.72.21.2-1.31.21.5
Locomotion distance, session 12.83.57.51.9-1.41.02.7
Locomotion velocity, session 27.28.411.33.4-3.02.52.6
Locomotion distance, session 24.96.89.72.5-2.62.03.1
Locomotion velocity, session 34.35.07.52.7-2.52.5-0.1
Locomotion distance, session 30.10.10.30.10.3-0.1-0.5
Stereotopy head waving bouts, day 35.16.18.83.0-2.82.51.2
Stereotopy head waving duration, day 35.16.18.52.9-2.92.70.8
Locomotion velocity, session 70.60.71.21.0-0.41.1-0.4
Locomotion distance, session 70.81.02.1-0.71.0-0.6-1.5
Stereotopy head waving bouts, day 70.70.81.70.9-0.60.51.3
Stereotopy head waving duration, day 71.21.52.51.2-1.11.01.6
Locomotion velocity, session 82.83.45.02.0-1.61.42.2
Locomotion distance, session 80.71.01.61.3-0.80.51.1
Degree of sensitization distance0.20.20.4-0.50.6-0.5-0.1
Degree of sensitization stereotypy0.70.81.0-0.91.0-0.90.8
Conditioned locomotion2.63.03.3-1.71.8-1.8-1.6
Cocaine response after cond. corrected8.19.111.7-3.43.3-2.9-2.3
Cocaine response after cond. not corrected8.79.611.7-3.43.4-3.0-2.5
Cocaine response before conditioning0.60.71.21.1-0.71.00.2
Saline control response0.10.10.1-0.30.3-0.4-0.2
Bone: connectivity density0.60.93.20.4-0.40.41.8
Bone: cortical apparent density0.71.02.2-1.50.9-1.0-0.1
Bone: cortical area0.20.30.7-0.40.4-0.10.8
Bone: cortical porosity1.11.21.21.1-1.11.11.0
Bone: cortical porosity1.01.02.30.9-0.80.71.5
Bone: cortical thickness0.50.81.1-1.00.9-0.90.5
Bone: cortical thickness0.60.71.7-0.80.6-0.4-1.3
Bone: cortical tissue density0.60.81.8-1.30.7-0.8-0.2
Condit. Reinf. active minus inactive responses3.33.75.82.4-2.22.00.3
Condit. Reinf. active-inactive response ratio0.91.01.31.0-1.11.1-0.7
Condit. Reinf. active responses4.75.88.42.9-2.72.31.6
Condit. Reinf. inactive responses2.93.54.42.0-1.81.42.1
Incentive salience index mean3.03.75.82.4-2.01.81.3
Condit. Reinf. lever presses1.92.56.31.4-1.10.72.5
Condit. Reinf. active minus inactive responses0.91.11.60.8-1.21.3-0.9
Condit. Reinf. active-inactive response ratio0.50.61.5-0.80.2-0.4-1.2
Condit. Reinf. active responses1.11.52.81.0-1.41.7-0.5
Condit. Reinf. inactive responses0.81.02.11.0-1.01.5-0.1
Condit. Reinf. lever presses1.01.42.01.2-1.31.4-0.9
Condit. Reinf. lever reinforcers received0.71.01.70.6-1.01.3-0.9
Conditioned reinforcement - actives1.61.62.51.6-1.31.50.2
Conditioned reinforcement - inactives0.70.81.3-0.81.1-1.0-0.6
Conditioned locomotion5.06.09.03.0-2.72.80.3
Patch foraging indifference point 0 sec0.00.10.1-0.30.2-0.20.4
Patch foraging indifference point AUC0.40.50.80.7-0.90.7-0.2
Delay disc. indifference point, 0s delay3.13.34.0-1.71.6-1.92.0
Delay disc. indifference point, 16s delay0.10.10.3-0.50.2-0.2-0.0
Delay disc. indifference point, 2s delay2.93.24.4-2.12.0-2.10.4
Delay disc. indifference point, 24s delay1.00.91.6-1.31.1-0.7-0.6
Delay disc. indifference point, 4s delay0.40.40.7-0.80.6-0.50.4
Delay disc. indifference point, 8s delay1.41.52.4-1.61.2-1.2-0.8
Indifference point function ln k0.30.40.7-0.80.8-0.4-0.4
Indifference point function log k0.30.40.7-0.80.8-0.4-0.4
Patch foraging total patch changes 0 sec0.00.00.1-0.30.2-0.20.2
Patch foraging total patch changes 12 sec0.70.91.2-0.80.9-1.1-1.0
Patch foraging total patch changes 18 sec0.81.01.61.1-1.31.10.0
Patch foraging total patch changes 24 sec0.10.10.20.2-0.50.20.2
Patch foraging total patch changes 6 sec0.20.40.70.4-0.80.70.4
Patch foraging time to switch 0 sec0.81.24.20.10.3-0.82.0
Patch foraging water rate 0 sec1.32.15.7-1.11.1-0.6-2.4
Patch foraging water rate 12 sec3.14.75.7-2.42.2-1.8-2.3
Patch foraging water rate 18 sec2.93.911.1-1.41.3-1.0-3.3
Patch foraging water rate 24 sec3.95.410.7-2.12.0-1.7-3.3
Patch foraging water rate 6 sec1.01.45.1-0.70.5-0.1-2.2
Seeking ratio, delayed vs. immediate footshock3.84.46.02.2-2.42.50.8
Distance traveled before self-admin0.30.40.5-0.70.5-0.50.7
Distance traveled after self-admin0.50.60.80.8-0.80.90.5
Extensor digitorum longus weight4.517.924.0-4.54.9-4.7-2.1
Bone: elastic displacement0.20.20.40.2-0.60.70.3
Bone: elastic work0.10.20.5-0.70.4-0.00.2
Bone: endosteal estimation0.10.10.2-0.40.4-0.30.3
Bone: endosteal perimeter0.51.01.41.1-0.91.20.8
Epididymis fat weight0.10.30.50.7-0.60.1-0.5
Delta time in closed arm before/after self-admin3.73.65.4-1.91.7-1.6-2.3
Delta time in open arm before/after self-admin0.50.50.7-0.80.7-0.80.5
Diff in mean of infusions in LGA sessions1.31.42.11.5-1.41.3-0.0
Delay discount exponential model param1.41.42.71.6-1.31.20.2
Extinction: sum of active levers before priming0.60.61.30.8-0.40.4-1.1
Active lever presses in extinction session 61.91.92.71.5-1.51.60.4
Bone: final force0.50.81.1-1.11.0-0.80.5
Bone: final moment0.40.61.0-1.00.9-0.60.5
Food consumed during 24 hour testing period0.81.02.0-1.41.0-0.8-0.6
Glucose1.42.13.2-1.81.6-1.5-0.5
Heart weight0.10.20.7-0.0-0.30.2-0.8
Delay discount hyperbolic model param1.81.93.41.8-1.51.40.1
Intermittent access intake day 1-15 change4.24.15.72.4-2.22.4-0.3
Intermittent access intake escalation3.02.93.71.9-1.81.9-1.1
Intermittent access intake escalation 23.83.74.72.2-2.02.1-1.3
Intermitt. access day 1 inactive lever presses0.30.31.0-0.20.20.0-1.0
Intermitt. access day 15 inactive lever presses0.20.20.30.6-0.50.5-0.2
Intermitt. access escalation Index0.40.41.4-0.0-0.20.31.2
Intermittent access day 1 total infusions0.00.00.0-0.10.2-0.10.1
Intermittent access day 15 total infusions0.91.01.51.2-1.01.2-0.6
Intermittent access terminal intake (last 3 days)0.60.71.11.1-0.81.0-0.2
Intermittent access total infusions0.10.10.20.4-0.20.3-0.2
Intermittent access day 1 locomotion0.20.20.30.6-0.50.5-0.0
Intermittent access day 15 total locomotion2.32.53.71.9-1.81.70.1
Intermittent access total locomotion0.70.81.31.1-1.01.00.4
Intermittent access standard deviation1.21.31.71.3-1.21.3-0.6
Left kidney weight0.10.40.70.3-0.60.60.8
Right kidney weight1.02.94.41.8-2.02.10.3
Cocaine induced anxiety1.61.82.61.3-1.31.21.6
Post-drug Anxiety1.41.62.21.3-1.31.01.5
Baseline Anxiety0.30.31.1-0.00.0-0.1-1.0
Tail length1.85.67.92.8-2.62.7-0.6
Length with tail1.65.98.42.7-2.72.90.7
Length without tail0.61.22.30.9-0.90.91.5
Times rat made contact with spout0.70.81.2-1.10.8-0.8-0.8
Lifetime Intake0.00.00.10.3-0.10.2-0.0
Liver weight, left2.13.45.6-1.92.0-2.4-0.7
Liver weight, right1.01.63.1-1.21.4-1.70.3
Locomotor activity4.06.48.22.6-2.82.91.6
Locomotor testing distance2.13.54.62.0-2.12.11.0
Locomotor testing rearing0.20.30.9-0.30.3-0.1-1.0
Locomotion in novel chamber0.10.10.1-0.1-0.30.1-0.3
Locomotion in novel chamber post-restriction0.50.60.90.8-0.71.0-0.7
Fecal boli incidents, locomotor time 11.41.53.0-1.41.1-1.7-0.1
Change in fecal boli incidents, locomotor task0.30.30.80.4-0.10.90.2
Time >=10cm from walls, locomotor time 10.40.51.6-0.50.20.01.2
Bouts of movement, locomotor time 10.10.10.10.3-0.10.2-0.3
Total resting periods, locomotor time 10.10.10.30.5-0.40.4-0.1
Rest time, locomotor task time 10.40.51.01.0-0.60.50.5
Distance moved, locomotor task time 10.30.30.9-0.60.40.10.9
Vertical activity count, locomotor time 10.70.81.5-1.20.7-0.3-1.0
Time >=10cm from walls, locomotor time 21.61.72.7-1.61.5-1.2-0.7
Bouts of movement, locomotor time 21.41.51.81.2-1.31.01.3
Total resting periods, locomotor time 21.41.52.01.2-1.31.01.4
Rest time, locomotor task time 21.01.11.31.0-1.21.10.9
Distance moved, locomotor task time 20.91.11.4-1.01.2-1.2-0.6
Vertical activity count, locomotor time 21.61.71.9-1.31.3-1.4-1.2
Light reinforcement 15.610.214.03.7-3.73.41.3
Light reinforcement 22.33.14.22.1-2.01.80.9
Bone: marrow area0.10.10.2-0.40.5-0.30.3
Bone: maximum diameter1.32.43.01.6-1.61.71.3
Bone: maximum force0.61.01.6-1.31.2-0.90.2
Bone: maximum moment0.50.81.4-1.21.1-0.80.2
Mean time between licks in bursts2.53.64.82.2-2.22.1-0.3
Mean num. licks in bursts0.00.00.2-0.10.10.00.4
Cd content in liver0.10.10.2-0.50.3-0.30.2
Co content in liver0.40.40.80.9-0.70.6-0.2
Cu content in liver0.30.41.50.3-0.20.21.2
Fe content in liver0.10.20.30.60.1-0.2-0.5
K content in liver1.01.02.21.1-0.60.41.5
Mg content in liver0.90.92.30.9-0.60.41.5
Mn content in liver4.04.55.72.3-1.91.92.4
Na content in liver0.60.61.80.40.3-0.61.3
Rb content in liver0.40.51.90.1-0.00.01.4
Se content in liver0.40.41.11.1-0.60.40.4
Sr content in liver0.50.51.4-0.40.4-0.4-1.2
Zn content in liver0.80.93.10.3-0.50.4-1.8
Bone: minimum diameter0.10.20.30.4-0.20.40.6
Time in familiar zone, hab. session 11.11.11.41.0-1.11.2-0.8
Time in novel zone, hab. session 10.50.51.1-0.60.6-0.41.1
Total zone transitions, hab. session 12.73.74.82.0-1.91.62.2
Total locomotion distance, hab. session 14.15.87.92.6-2.22.02.8
Locomotion velocity, hab. session 14.46.37.72.8-2.42.02.7
Time in familiar zone, hab. session 22.82.93.81.7-2.01.9-1.1
Time in novel zone, hab. session 22.32.33.4-1.91.7-1.50.9
Total zone transitions, hab. session 22.02.68.90.8-1.00.43.0
Total locomotion distance, hab. session 22.93.85.51.9-2.01.52.3
Locomotion velocity, hab. session 23.64.98.32.0-2.21.62.9
Novel to familiar place preference ratio1.92.02.3-1.41.5-1.31.3
Novelty place preference1.21.21.7-1.01.1-0.91.3
Time in novel zone, NPP test1.31.41.6-1.21.3-1.11.1
Total zone transitions, NPP test1.21.75.00.9-1.00.22.2
Total locomotion distance, NPP test1.21.74.71.1-0.80.32.2
Locomotion velocity, NPP test1.42.05.01.2-1.10.62.2
Intraocular pressure1.11.63.9-1.10.7-0.7-2.0
Delta distance traveled before/after self-admin1.41.62.51.6-1.31.40.1
Delta ambulatory time before/after self-admin1.71.93.01.7-1.51.50.4
Parametrial fat weight0.20.40.60.5-0.50.8-0.6
Pavlov. Cond. lever latency0.81.02.3-1.10.5-0.4-1.5
Pavlov. Cond. magazine entry latency2.43.05.72.4-1.91.70.1
Pavlov. Cond. change in total contacts0.30.30.80.9-0.40.30.4
Pavlov. Cond. index score1.21.53.01.7-1.10.91.0
Pavlov. Cond. latency score1.62.13.71.9-1.21.01.4
Pavlov. Cond. lever contacts1.31.53.11.4-0.80.71.8
Pavlov. Cond. magazine entry number0.81.02.3-1.51.1-0.8-0.3
Pavlov. Cond. intertrial magazine entries0.20.31.0-0.3-0.0-0.1-1.0
Pavlov. Cond. lever-magazine prob. diff.1.51.93.71.9-1.31.10.9
Pavlov. Cond. response bias1.31.53.21.8-1.31.10.4
Pavlov. Cond. lever latency0.50.61.5-0.60.7-1.20.4
Pavlov. Cond. magazine entry latency0.40.40.80.7-0.50.9-0.2
Pavlov. Cond. change in total contacts0.30.51.00.4-0.71.0-0.5
Pavlov. Cond. index score0.50.61.40.7-0.71.2-0.5
Pavlov. Cond. latency score0.50.71.50.7-0.81.2-0.3
Pavlov. Cond. lever contacts0.40.51.00.4-0.51.0-0.8
Pavlov. Cond. magazine entry number0.60.71.3-1.00.7-1.10.3
Pavlov. Cond. intertrial magazine entries0.70.91.0-1.01.0-0.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.60.71.60.8-0.81.3-0.3
Pavlov. Cond. response bias0.91.22.20.9-1.01.5-0.9
Time in closed arm before self-admin0.60.72.70.10.0-0.31.7
Time in closed arm after self-admin0.00.00.10.00.00.0-0.2
Time in open arm before self-admin0.30.40.60.6-0.50.8-0.5
Time in open arm after self-admin0.60.71.1-1.10.9-0.9-0.3
Bone: periosteal estimation0.10.30.9-0.30.3-0.00.9
Bone: periosteal perimeter0.50.81.10.8-0.71.01.0
Bone: post-yield work0.50.61.0-0.71.0-0.9-0.6
Progressive ratio test 1 active lever presses0.20.20.3-0.50.5-0.5-0.5
Progressive ratio test 1 breakpoint0.30.30.4-0.60.6-0.5-0.4
Progressive ratio test 1 inactive lever presses0.00.00.10.2-0.10.10.3
Progressive ratio test 2 active lever presses0.10.10.60.00.10.0-0.7
Progressive ratio test 2 breakpoint0.10.10.10.3-0.20.3-0.3
Progressive ratio test 2 inactive lever presses0.10.10.20.4-0.20.20.4
Incentive Sensitization - Responses0.20.20.8-0.00.2-0.0-0.9
Incentive Sensitization - Breakpoint0.10.10.60.10.10.1-0.7
Sum of active levers in priming session hrs 5-60.00.00.00.1-0.0-0.10.2
Progressive ratio0.20.30.9-0.20.4-0.9-0.2
Food seeking constrained by brief footshock0.50.61.21.1-0.70.20.7
Seeking ratio, punishment vs. effort0.40.50.60.8-0.70.70.6
Retroperitoneal fat weight0.30.91.5-1.01.0-1.2-0.5
Reaction time number correct2.13.04.3-1.71.7-1.3-2.1
Reaction time mean minus median0.30.40.70.6-0.60.8-0.5
Reaction time mean minus median AUC0.20.30.70.3-0.30.50.8
Reaction time num false alarms0.91.22.8-0.71.1-0.4-1.7
Reaction time num false alarms AUC1.21.63.6-0.91.3-0.7-1.9
Reaction time trials correct on left2.13.04.3-1.71.7-1.3-2.1
Reaction time trials on left2.02.83.9-1.71.7-1.3-2.0
Reaction time mean0.10.10.2-0.1-0.10.30.5
Reaction time mean AUC0.10.10.2-0.2-0.00.30.5
Median of all reaction times0.10.20.4-0.50.3-0.10.6
Reaction time omissions0.30.40.60.4-0.80.70.6
Reaction time false alarm rate0.10.10.20.00.3-0.0-0.4
Reaction time premature initiation rate0.40.50.70.5-0.90.8-0.7
Reaction time premature initiations0.70.93.5-0.4-0.00.2-1.9
Std. dev. reaction times0.10.10.40.2-0.40.6-0.0
Reaction time trials completed2.02.83.9-1.71.7-1.3-2.0
Reaction time trials AUC2.33.35.0-1.81.7-1.3-2.2
Run reversals in cocaine runway, females0.40.40.50.7-0.60.70.3
Run reversals in cocaine runway, males1.71.62.21.4-1.51.30.7
Latency to leave start box in cocaine runway1.92.02.41.2-1.51.51.6
Latency to leave start box in cocaine runway, F1.41.54.60.4-0.80.72.1
Latency to leave start box in cocaine runway, M1.21.11.21.1-1.01.1-1.0
Std. dev. time between licks in bursts0.81.01.91.0-1.01.40.3
Total sessions with >9 infusions0.10.10.30.10.10.20.5
Short access day 1 total inactive lever presses0.10.10.20.4-0.30.20.5
Short access day 10 total inactive lever presses0.10.10.2-0.20.2-0.2-0.4
Short access day 1 total infusions0.70.81.20.9-0.70.71.1
Short access day 10 total infusions0.00.00.1-0.00.2-0.1-0.3
Short access total infusions0.00.00.10.20.00.10.3
Short access day 1 locomotion1.31.41.91.3-1.11.40.9
Short access day 10 total locomotion2.12.43.51.8-1.61.9-0.2
Short access total locomotion0.70.81.21.0-0.81.10.4
One hour access (0.3 mA shock)0.10.20.3-0.30.5-0.5-0.0
Compulsive drug intake0.60.60.7-0.80.8-0.80.6
One hour access (shock baseline)0.10.10.40.00.2-0.0-0.6
Social response proportion1.31.42.11.2-1.41.01.2
Social responses6.48.311.03.2-3.33.31.0
Social time0.30.40.9-0.60.5-1.00.4
Soleus weight6.920.127.7-5.25.3-5.0-1.2
Bone: stiffness1.52.33.8-1.61.9-1.70.0
Tibialis anterior weight0.93.04.6-1.72.2-2.0-0.5
Time to tail flick, vehicle, before self-admin1.31.31.71.0-1.21.01.3
Time to tail flick, vehicle, after self-admin0.50.62.20.10.2-0.2-1.5
Time to tail flick, test, before self-admin1.01.01.70.8-0.90.81.3
Time to tail flick, test, after self-admin0.50.50.80.8-0.90.60.7
Delta time to tail flick, vehicle, before/after SA2.12.03.9-1.01.3-1.2-2.0
Delta time to tail flick, test, before/after SA0.20.20.60.1-0.1-0.1-0.8
Tibia length0.61.62.41.3-1.51.5-0.0
Ambulatory time before self-admin0.30.30.4-0.60.5-0.50.5
Ambulatory time after self-admin0.30.40.40.6-0.60.60.5
Bone: tissue strength0.90.91.2-1.11.0-1.10.4
Total heroin consumption1.31.62.31.5-1.41.40.0
Bone: trabecular number1.82.83.01.7-1.61.61.7
Bone: trabecular spacing3.34.37.3-1.91.8-1.7-2.7
Bone: trabecular thickness3.64.411.31.2-1.51.63.4
Bone: trabecular tissue density1.62.23.5-1.61.6-1.9-0.6
Water consumed over 24 hours0.30.40.6-0.70.5-0.30.8
Number of responses in last shaping day0.10.10.20.4-0.20.40.1